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Target
Mu-type opioid receptor
Ligand
BDBM471982
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
0.800±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM471982
Synonyms:
CIS-2-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-methyl]-benzamide | US10829480, Example SC_2006
Type:
Small organic molecule
Emp. Form.:
C29H38N4O2
Mol. Mass.:
474.6376
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3ccccc3C(N)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(13.3,8.59,;13.7,7.1,;15.19,6.7,;12.61,6.01,;11.84,4.68,;10.3,4.68,;9.53,6.01,;8.63,7.26,;7.16,6.78,;5.83,7.55,;4.5,6.78,;4.5,5.24,;3.16,4.47,;1.83,5.24,;1.83,6.78,;3.16,7.55,;3.16,9.09,;4.5,9.86,;1.83,9.86,;7.16,5.24,;5.83,4.47,;8.63,4.76,;9.03,3.28,;7.94,2.19,;6.4,2.19,;6.4,.65,;7.94,.65,;10.3,7.34,;11.84,7.34,;13.7,4.92,;13.7,3.38,;15.03,2.61,;16.37,3.38,;16.37,4.92,;15.04,5.69,)|
Structure:
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