Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM300559
Substrate
n/a
Meas. Tech.
HCT116 TOPFlash Assay
IC50
900±n/a nM
Citation
 Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent  US10130633 Publication Date 11/20/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM300559
Synonyms:
3-{[2-(4-methylpiperazin-1-yl)propanoyl]amino}-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-4-(trifluoromethyl)benzamide | US10130633, Example 129
Type:
Small organic molecule
Emp. Form.:
C24H25F3N6O2S
Mol. Mass.:
518.555
SMILES:
CC(N1CCN(C)CC1)C(=O)Nc1cc(ccc1C(F)(F)F)C(=O)Nc1nnc(s1)-c1ccccc1 |$;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$|
Structure:
Search PDB for entries with ligand similarity: