Compile Data Set for Download or QSAR
Report error Found 421 Enz. Inhib. hit(s) with all data for entry = 13327
TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547925BDBM50547925(CHEMBL4798938 | US12441703, Compound 320)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547926BDBM50547926(CHEMBL4753280 | US12441703, Compound 323)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547929BDBM50547929(CHEMBL4744908 | US12441703, Compound 326)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547924BDBM50547924(CHEMBL4750365 | US12441703, Compound 309)
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547928BDBM50547928(CHEMBL4787299 | US12441703, Compound 325)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547927BDBM50547927(CHEMBL4756380 | US12441703, Compound 324)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547930BDBM50547930(CHEMBL4782190 | US12441703, Compound 352)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781487BDBM781487(4-[[2-Fluoro-4-Methoxy-6-[2-Methoxy-4-(Trifluorome...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781533BDBM781533(4-[[6-[2-Methoxy-4-(Trifluoromethoxy)Phenoxy]-2-Me...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781276BDBM781276(4-[[2-Fluoro-6-[2-Methoxy-4-(Trifluoromethoxy)Phen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781243BDBM781243(US12441703, Compound 117)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547922BDBM50547922(CHEMBL4761578 | US12441703, Compound 194)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547921BDBM50547921(CHEMBL4785523 | US12441703, Compound 191)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547923BDBM50547923(CHEMBL4763419 | US12441703, Compound 305)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781471BDBM781471(US12441703, Compound 345)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781438BDBM781438(4-[[3-Cyclobutyl-2-Fluoro-6-[3-Fluoro-2-Methoxy-4-...)
Affinity DataIC50: 2.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781459BDBM781459(N-(2-Carbamoyl-4-Pyridyl)-3-Fluoro-5-[3-Fluoro-2-M...)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781394BDBM781394(4-[[3-Chloro-2-Fluoro-4-Methoxy-6-[2-Methoxy-4-(Tr...)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781488BDBM781488(4-[[2-Chloro-4-Methoxy-6-[2-Methoxy-4-(Trifluorome...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547919BDBM50547919(CHEMBL4764805 | US12441703, Compound 147)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781473BDBM781473(4-[[6-[2-Ethoxy-4-(Trifluoromethoxy)Phenoxy]-2-Flu...)
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781482BDBM781482(US12441703, Compound 356)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781406BDBM781406(4-[[2-Fluoro-6-[2-Methoxy-4-(Trifluoromethoxy)Phen...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781421BDBM781421(4-[[2-Fluoro-6-[3-Fluoro-2-Methyl-4-(Trifluorometh...)
Affinity DataIC50: 3.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781412BDBM781412(4-[[2-Fluoro-3-Methoxy-6-[2-Methoxy-4-(Trifluorome...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781408BDBM781408(4-[[2-Fluoro-6-[2-Methoxy-4-(Trifluoromethoxy)Phen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50547920BDBM50547920(CHEMBL4759624 | US12441703, Compound 151)
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781320BDBM781320(US12441703, Compound 192)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781411BDBM781411(4-[[4-Methoxy-6-[2-Methoxy-4-(Trifluoromethoxy)Phe...)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781458BDBM781458(US12441703, Compound 331)
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781470BDBM781470(US12441703, Compound 344)
Affinity DataIC50: 4.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781469BDBM781469(US12441703, Compound 343)
Affinity DataIC50: 4.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781460BDBM781460(N-(2-Carbamoyl-4-Pyridyl)-5-[3-Fluoro-2-Methoxy-4-...)
Affinity DataIC50: 4.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781493BDBM781493(4-[[6-[2-Chloro-4-(Trifluoromethoxy)Phenoxy]-2-Flu...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781506BDBM781506(4-(6-(2-Chloro-4-Fluorophenoxy)-2-Fluoro-3-Methoxy...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781323BDBM781323(US12441703, Compound 195)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781447BDBM781447(4-[[3-(Difluoromethyl)-6-[3-Fluoro-2-(Trideuteriom...)
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781463BDBM781463(N-(2-Carbamoyl-5-Methyl-4-Pyridyl)-5-[3-Fluoro-2-M...)
Affinity DataIC50: 5.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781472BDBM781472(4-[[6-[2-Ethoxy-4-(Trifluoromethoxy)Phenoxy]-2-Flu...)
Affinity DataIC50: 5.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781435BDBM781435(4-[[2,3,4-Trifluoro-6-[3-Fluoro-2-Methoxy-4-(Trifl...)
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781330BDBM781330(4-[[2,2-Difluoro-6-[2-Methoxy-4-(Trifluoromethoxy)...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781548BDBM781548(US12441703, Compound 1040)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781321BDBM781321(US12441703, Compound 193)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781497BDBM781497(4-[[4-Chloro-6-(3,4-Difluoro-2-Methoxy-Phenoxy)-2-...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781352BDBM781352(5-[[6-[3-Fluoro-2-Methoxy-4-(Trifluoromethoxy)Phen...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781450BDBM781450(4-[[2-Fluoro-6-[3-Fluoro-2-Methoxy-4-(Trifluoromet...)
Affinity DataIC50: 6.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781427BDBM781427(4-[[6-(3,4-Difluoro-2-Methoxy-Phenoxy)-2-Fluoro-4-...)
Affinity DataIC50: 6.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781442BDBM781442(US12441703, Compound 314)
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781423BDBM781423(4-[[3-Chloro-2-Fluoro-6-[3-Fluoro-2-Methyl-4-(Trif...)
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 781422BDBM781422(4-[[2-Fluoro-6-[3-Fluoro-2-Methyl-4-(Trifluorometh...)
Affinity DataIC50: 6.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

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