Patent

Data

Cmpds

HGNC*

Patent Title

Organization

Deposition

Downloads

20

6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use

Purdue Research Foundation

05/11/23

2D 3D TSV

1533

Aminopyrrolotriazines as kinase inhibitors

Bristol-Myers Squibb Company

05/11/23

2D 3D TSV

186

Benzoimidazoles as prolyl hydroxylase inhibitors

Janssen Pharmaceutica NV

05/11/23

2D 3D TSV

18

Compounds active towards nuclear receptors

NUEVOLUTION A/S

05/10/23

2D 3D TSV

19

Heterocyclic compounds as immunomodulators

Incyte Corporation

05/10/23

2D 3D TSV

36

Oxysterols and methods of use thereof

SAGE THERAPEUTICS, INC.

05/10/23

2D 3D TSV

83

Substituted pyridotriazine compounds and uses thereof

Gilead Sciences, Inc.

05/10/23

2D 3D TSV

24

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

SHAANXI PANLONG PHARMACEUTICAL CO., LTD.

05/09/23

2D 3D TSV

302

8-aminoisoquinoline compounds and uses thereof

Genentech, Inc.

05/09/23

2D 3D TSV

116

HGNC:6371 3529 6357

Enzyme inhibitors

KalVista Pharmaceuticals Limited

05/09/23

2D 3D TSV

123

Glycosidase inhibitors

Asceneuron SA

05/09/23

2D 3D TSV

167

Inhibitors of RHO associated coiled-coil containing protein kinase

Kadmon Corporation, LLC

05/09/23

2D 3D TSV

10

Pharmaceutical formulations comprising CCR3 antagonists

Alkahest, Inc.

05/09/23

2D 3D TSV

62

Substituted condensed thiophenes as modulators of sting

CTXT PTY LIMITED

05/09/23

2D 3D TSV

22

HGNC:10251 27972 26249

Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase

INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

05/05/23

2D 3D TSV

106

Bicyclic amide compounds and methods of use thereof

Genentech, Inc.

05/05/23

2D 3D TSV

9

HGNC:7175 7176 7166 7159

Curcumin analogues as zinc chelators and their uses

THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; CHEM-MASTER INTERNATIONAL INC.

05/05/23

2D 3D TSV

42

HGNC:3691 3688

FGFR4 inhibitor and preparation method and use thereof

Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.

05/05/23

2D 3D TSV

40

Heterocyclic compounds as immunomodulators

Incyte Corporation

05/05/23

2D 3D TSV

138

HGNC:8978 795 8975 3942 8977 8976

Imidazolonylquinolines and the use thereof as ATM kinase inhibitors

Merck Patent GmbH

05/05/23

2D 3D TSV

161

HGNC:6833 6834 2671 6666

Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL

05/05/23

2D 3D TSV

93

Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors

Hoffmann-La Roche Inc.

05/05/23

2D 3D TSV

5

HGNC:8795 8774

PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases

H. Lundbeck A/S

05/05/23

2D 3D TSV

19

Compounds and therapeutic uses thereof

VioGen Biosciences, LLC

04/30/23

2D 3D TSV

64

HGNC:3711 3721

MTORC1 modulators and uses thereof

Aeovian Pharmaceuticals, Inc.

04/30/23

2D 3D TSV

285

PCSK9 inhibitors and methods of use thereof

AstraZeneca AB

04/30/23

2D 3D TSV

34

Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors

Array BioPharma Inc.

04/30/23

2D 3D TSV

19

Compounds and compositions for the treatment of parasitic diseases

Novartis AG

04/23/23

2D 3D TSV

53

Cyclic dinucleotides as sting agonists

Janssen Biotech, Inc.

04/23/23

2D 3D TSV

10

Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)

THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY

04/23/23

2D 3D TSV

26

JAK1 pathway inhibitors for the treatment of gastrointestinal disease

Incyte Corporation

04/23/23

2D 3D TSV

429

Monoacylglycerol lipase modulators

Janssen Pharmaceutica NV

04/23/23

2D 3D TSV

20

PD-L1/STING conjugates and methods of use

Incyte Corporation

04/23/23

2D 3D TSV

4

Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

MINDSET PHARMA INC.

04/23/23

2D 3D TSV

3

SHP2 inhibitor compositions and methods for treating cancer

Revolution Medicines, Inc.

04/23/23

2D 3D TSV

719

Substituted indole Mcl-1 inhibitors

Vanderbilt University

04/23/23

2D 3D TSV

28

HGNC:992 990

Benzamide compounds

Recurium IP Holdings, LLC

04/14/23

2D 3D TSV

26

Bicyclic heterocycles as FGFR inhibitors

Incyte Corporation

04/14/23

2D 3D TSV

13

Bipyrazole derivatives as JAK inhibitors

Incyte Corporation

04/14/23

2D 3D TSV

27

Certain chemical compositions and methods of use thereof

Algen Biotechnologies, Inc.

04/14/23

2D 3D TSV

164

Compounds, compositions, and methods

Denali Therapeutics Inc.

04/14/23

2D 3D TSV

46

Heterocyclic compound, application thereof and pharmaceutical composition comprising same

SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.

04/14/23

2D 3D TSV

26

HGNC:8803 8804 6342

Highly active CSF1R inhibitor compound

XIAMEN BIOTIME BIOTECHNOLOGY CO., LTD.

04/14/23

2D 3D TSV

25

Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof

HINOVA PHARMACEUTICALS INC.

04/14/23

2D 3D TSV

40

HGNC:3356 3357

Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof

STINGRAY THERAPEUTICS, INC.

04/14/23

2D 3D TSV

73

Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof

Pharmablock Sciences (Nanjing), Inc.

04/14/23

2D 3D TSV

14

Oxazolidinone antibiotic compounds and process of preparation

BUGWORKS RESEARCH, INC.

04/14/23

2D 3D TSV

99

HGNC:270 272

PARP1 inhibitors and uses thereof

XINTHERA, INC.

04/14/23

2D 3D TSV

3

Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

Mindset Pharma Inc.

04/14/23

2D 3D TSV

144

HGNC:7027 12446

Pyrrolotriazine compounds as TAM inhibitors

Incyte Corporation

04/14/23

2D 3D TSV

51

Small molecule inducers of autophagy

Board of Regents, The University of Texas System

04/14/23

2D 3D TSV

514

Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors

D. E. Shaw Research, LLC; Relay Therapeutics, Inc.

04/14/23

2D 3D TSV

4

HGNC:6251 14299

Amino alcohol derivative, pharmaceutical composition and application thereof

BEIJING FORELAND PHARMA CO., LTD.

04/09/23

2D 3D TSV

15

Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof

SHANGHAI YINGLI PHARMACEUTICAL CO., LTD

04/09/23

2D 3D TSV

6

Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia

STEALTH BIOTHERAPEUTICS INC.

04/09/23

2D 3D TSV

13

HGNC:17663 16490 18648 3590 3009 14892

Dash inhibitors, and uses related thereto

Trustees of Tufts College

04/09/23

2D 3D TSV

165

HGNC:3650 3437

Dihydrothieno[3,2-b]pyridine compounds

IDEAYA BIOSCIENCES, INC.

04/09/23

2D 3D TSV

33

Heterocyclic compounds as BET inhibitors

NUVATION BIO INC.

04/09/23

2D 3D TSV

27

Inhibitors of EGFR and methods of use thereof

Dana-Farber Cancer Institute, Inc.

04/09/23

2D 3D TSV

479

MASP-2 inhibitors and methods of use

OMEROS CORPORATION

04/09/23

2D 3D TSV

22

Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators

Heptares Therapeutics Limited

04/09/23

2D 3D TSV

57

RIP1K inhibitors

Rigel Pharmaceuticals, Inc.

04/09/23

2D 3D TSV

2

HGNC:3530 6371 9475 3529 3535 6357 9071

Solid forms of a plasma kallikrein inhibitor and salts thereof

KalVista Pharmaceuticals Limited

04/09/23

2D 3D TSV

80

Spirocyclic compounds

C4 Therapeutics, Inc.

04/09/23

2D 3D TSV

225

Substituted pyridopyrimidinonyl compounds useful as T cell activators

TBA

04/09/23

2D 3D TSV

145

Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors

VENENUM BIODESIGN, LLC

04/09/23

2D 3D TSV

73

Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors

Boehringer Ingelheim International GmbH

04/09/23

2D 3D TSV

21

Compounds useful as immunomodulators

Bristol-Myers Squibb Company

03/31/23

2D 3D TSV

227

Condensed ring compounds having dopamine D3 receptor antagonistic effect

Shionogi & Co., Ltd.

03/31/23

2D 3D TSV

289

Fluoroalkyl-oxadiazoles and uses thereof

Tenaya Therapeutics, Inc.

03/31/23

2D 3D TSV

22

Heterocyclic RIP1 inhibitory compounds

Rigel Pharmaceuticals, Inc.

03/31/23

2D 3D TSV

3

HGNC:6192 12440

Heterocyclic compounds for inhibiting TYK2 activities

Beijing Innocare Pharma Tech Co.

03/31/23

2D 3D TSV

20

Inhibiting mutant IDH-1

FORMA Therapeutics, Inc.

03/31/23

2D 3D TSV

282

Inhibitors of LRRK2 kinase

HALIA THERAPEUTICS, INC.

03/31/23

2D 3D TSV

72

Spiro-oxazolones

Hoffmann-La Roche Inc.

03/31/23

2D 3D TSV

64

Therapeutic agent for non-motor symptoms associated with Parkinson's disease

Sumitomo Pharma Co., Ltd.

03/31/23

2D 3D TSV

23

Thienopyrimidones

Boehringer Ingelheim International GmbH

03/31/23

2D 3D TSV

29

HGNC:3690 3691 3689 3688

Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof

Beijing Innocare Pharma Tech Co., Ltd.

03/26/23

2D 3D TSV

44

Antibacterial agents: arylalkylcarboxamido phloroglucinols

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

03/26/23

2D 3D TSV

4

HGNC:13575 1103 1105 1104

BRD4 inhibitor

HINOVA PHARMACEUTICALS INC.

03/26/23

2D 3D TSV

14

Cyanoaryl-aniline compounds for treatment of dermal disorders

NFLECTION THERAPEUTICS, INC.

03/26/23

2D 3D TSV

40

Heterocyclic compounds as immunomodulators

Incyte Corporation

03/26/23

2D 3D TSV

26

HGNC:11708 6059

Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof

University Health Network

03/26/23

2D 3D TSV

171

HGNC:4852 4854 4853

Inhibitors of histone deacetylase

The General Hospital Corporation; The Broad Institute, Inc.; Massachusetts Institute of Technology

03/26/23

2D 3D TSV

452

N-cyano-7-azanorbornane derivatives and uses thereof

AMGEN INC.

03/26/23

2D 3D TSV

38

HGNC:262 263 264

Pyrazine compounds and uses thereof

DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.

03/26/23

2D 3D TSV

73

Pyrrolo[1,2-b]pyridazine derivatives

Gilead Sciences, Inc.

03/26/23

2D 3D TSV

69

HGNC:3690 3691 3689 3688

Bicyclic heterocycles as FGFR inhibitors

Incyte Corporation

03/20/23

2D 3D TSV

4

Heterocyclic compounds as immunomodulators

Incyte Corporation

03/20/23

2D 3D TSV

2

Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)

FORMA Therapeutics, Inc.

03/20/23

2D 3D TSV

39

HGNC:1925 6251

5-heteroaryl-1H-pyrazol-3-amine derivative

Sumitomo Pharma Co., Ltd.

03/19/23

2D 3D TSV

158

5-membered heteroaryl carboxamide compounds for treatment of HBV

Assembly Biosciences, Inc.

03/19/23

2D 3D TSV

145

Amino acid compounds and methods of use

Pliant Therapeutics, Inc.

03/19/23

2D 3D TSV

70

Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof

Enanta Pharmaceuticals, Inc.

03/19/23

2D 3D TSV

17

Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease

Board of Regents, The University of Texas System

03/19/23

2D 3D TSV

158

HGNC:2160 2159

Cannabinoid receptor type 2 (CB2) modulators and uses thereof

Teon Therapeutics, Inc.

03/19/23

2D 3D TSV

50

HGNC:16490 18648 3590 3009 9358 14892

Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists

Trustees of Tufts College

03/19/23

2D 3D TSV

487

Compounds and uses thereof

Foghorn Therapeutics Inc.

03/19/23

2D 3D TSV

4

Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex

AlternOx Scientific Limited

03/19/23

2D 3D TSV

62

HGNC:5253 1735

Fused amino pyridine as HSP90 inhibitors

Guris, Inc.

03/19/23

2D 3D TSV

377

Indole compounds and analogues thereof

BioCryst Pharmaceuticals, Inc.

03/19/23

2D 3D TSV

373

Isoquinolines as inhibitors of HPK1

Genentech, Inc.

03/19/23

2D 3D TSV

17

Morpholinylpyridone compounds

Sprint Bioscience AB

03/19/23

2D 3D TSV

175

Proteasome activity enhancing compounds

Proteostasis Therapeutics, Inc.

03/19/23

2D 3D TSV

22

RIP1 inhibitory compounds and methods for making and using the same

Rigel Pharmaceuticals, Inc.

03/19/23

2D 3D TSV

718

HGNC:7989 6407

Ras inhibitors

Revolution Medicines, Inc.

03/19/23

2D 3D TSV

149

Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors

Pfizer Inc.

03/19/23

2D 3D TSV

17

2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

03/12/23

2D 3D TSV

474

ACLY inhibitors and uses thereof

Nimbus Artemis, Inc.

03/12/23

2D 3D TSV

98

HGNC:10251 10252

Amide compounds as kinase inhibitors, compositions and methods of treatment

Translational Drug Development LLC

03/12/23

2D 3D TSV

215

HGNC:6735 1133 6171 11719 3236 6524

Bruton's tyrosine kinase inhibitors

SUZHOU BAIJIBUGONG PHARMACEUTICAL TECHNOLOGY CO., LTD.

03/12/23

2D 3D TSV

656

PD-1/PD-L1 inhibitors

Gilead Sciences, Inc.

03/12/23

2D 3D TSV

22

Phosphonate linkers and their use to facilitate cellular retention of compounds

Merck Sharp & Dohme LLC

03/12/23

2D 3D TSV

59

Potent and selective inhibitors of monoamine transporters; method of making; and use thereof

THE USA, AS REPRESENTED BY THE SECRETARY, DHHS

03/12/23

2D 3D TSV

46

HGNC:934 2529 933

Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

Amgen Inc.

03/06/23

2D 3D TSV

21

Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers

Jazz Pharmaceuticals Ireland Limited

03/06/23

2D 3D TSV

109

HGNC:6307 9967

Heterocyclic compounds as RET kinase inhibitors

Cancer Research Technology Limited

03/06/23

2D 3D TSV

137

HGNC:3430 3236

Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof

BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

03/06/23

2D 3D TSV

23

Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections

Gilead Sciences, Inc.

03/06/23

2D 3D TSV

581

Transglutaminase 2 (TG2) inhibitors

Sitari Pharma, Inc.

03/06/23

2D 3D TSV

80

Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same

LegoChem Biosciences, Inc.

03/05/23

2D 3D TSV

822

HPK1 antagonists and uses thereof

Nimbus Saturn, Inc.

03/05/23

2D 3D TSV

523

HGNC:8978 8975 3942 8977 8976

Heterocyclic compounds and uses thereof

MILLENNIUM PHARMACEUTICALS, INC.

03/05/23

2D 3D TSV

238

Isoquinolin-3-yl carboxamides and preparation and use thereof

BioSplice Therapeutics, Inc.

03/05/23

2D 3D TSV

45

Kinase inhibitor compounds and compositions and methods of use

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

03/05/23

2D 3D TSV

9

LSD1 inhibitors and medical uses thereof

Constellation Pharmaceuticals, Inc.

03/05/23

2D 3D TSV

59

Neprilysin inhibitors

THERAVANCE BIOPHARMA R&D IP, LLC

03/05/23

2D 3D TSV

13

HGNC:2594 2593 2637 2625 2623

Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1

MANGOSUTHU UNIVERSITY OF TECHNOLOGY

03/05/23

2D 3D TSV

31

Therapeutic compounds and methods of use thereof

LIGATURE THERAPEUTICS PTE. LTD.

03/05/23

2D 3D TSV

5

Amide compound having bet proteolysis-inducing action and medicinal application thereof

MITSUBISHI TANABE PHARMA CORPORATION

02/26/23

2D 3D TSV

47

HGNC:1133 3236

BTK inhibitor compounds

Eli Lilly and Company

02/26/23

2D 3D TSV

10

HGNC:6307 3690 3691 3689 3688

Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer

Janssen Pharmaceutica NV

02/26/23

2D 3D TSV

230

Compositions and methods for treating CNS disorders

Sage Therapeutics, Inc.

02/26/23

2D 3D TSV

6

HGNC:6367 6357 9071

Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases

SARBONNE UNIVERSITE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE; ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS; INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE; UNIVERSITÉ DE MONTPELLIER; ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER

02/26/23

2D 3D TSV

65

Compounds for the treatment of kinase-dependent disorders

Exelixis, Inc.

02/26/23

2D 3D TSV

25

Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease

SHY Therapeutics LLC

02/26/23

2D 3D TSV

108

HGNC:8978 8975 8977 8976

Heterocyclic compounds and uses thereof

Infinity Pharmaceuticals, Inc.

02/26/23

2D 3D TSV

6

HGNC:6112 17967

IRAK degraders and uses thereof

DANA-FARBER CANCER INSTITUTE, INC.

02/26/23

2D 3D TSV

27

Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors

UNIVERSISITY OF UTAH RESEARCH FOUNDATION

02/26/23

2D 3D TSV

42

Phenothiazine derivatives and uses thereof

CAMP4 THERAPEUTICS CORPORATION

02/26/23

2D 3D TSV

126

Pyrazolopyrimidine compounds and uses thereof

Incyte Corporation

02/26/23

2D 3D TSV

5

HGNC:6112 17967

Quinoline compounds as IRAK inhibitors and uses thereof

Merck Patent GmbH

02/26/23

2D 3D TSV

17

STK19 inhibitors for treatment of cancer

TRUSTEES OF BOSTON UNIVERSITY; XIAMEN UNIVERSITY

02/26/23

2D 3D TSV

46

Sting modulator compounds, and methods of making and using

Takeda Pharmaceutical Company Limited

02/26/23

2D 3D TSV

51

HGNC:11305 7989 1057 8804 1778 6112 17967 9967 6524

Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors

CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

02/26/23

2D 3D TSV

96

Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors

AURIGENE DISCOVERY TECHNOLOGIES LIMITED

02/26/23

2D 3D TSV

71

HGNC:4852 6251 4854 4853

Substituted piperazines as selective HDAC1,2 inhibitors

REGENACY PHARMACEUTICALS, LLC

02/26/23

2D 3D TSV

1

Substituted piperidines as BTK inhibitors

HAISCO PHARMACEUTICALS PTE. LTD.

02/26/23

2D 3D TSV

8

Synthesis of peptide borate ester compound and use thereof

JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO., LTD.

02/26/23

2D 3D TSV

5

HGNC:3528 3529 3544

Tetrahydroisoquinoline derivatives, preparation process and use thereof

Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

02/26/23

2D 3D TSV

94

Therapeutic compounds and methods of use thereof

Agency for Science, Technology and Research (A*STAR)

02/26/23

2D 3D TSV

16

HGNC:4584 8157

Analogs of dextromethorphan with balanced receptor activities

Center for Neurologic Study

02/20/23

2D 3D TSV

11

Benzisoxazole derivative

Sumitomo Pharma Co., Ltd.

02/20/23

2D 3D TSV

155

Dihydropyrrolopyridine inhibitors of ROR-gamma

Vitae Pharmaceuticals, LLC

02/20/23

2D 3D TSV

15

HGNC:3526 3527

Dioxoloisoquinolinone derivatives and use thereof

HANMI PHARMACEUTICAL CO., LTD.

02/20/23

2D 3D TSV

287

Heterobicyclic amides as inhibitors of CD38

Ribon Therapeutics, Inc.

02/20/23

2D 3D TSV

21

Heterocyclic compounds as immunomodulators

Incyte Corporation

02/20/23

2D 3D TSV

26

HGNC:4852 14064 19086 13315

Histone deacetylases (HDACs) inhibitors

AnnJi Pharmaceutical Co., Ltd.

02/20/23

2D 3D TSV

115

Histone demethylase inhibitors

CELGENE QUANTICEL RESEARCH, INC

02/20/23

2D 3D TSV

100

HGNC:4852 14065 14064 19086 14063 14068 14067 13315 4854 4853 18128

Isoindolines as HDAC inhibitors

Valo Health, Inc.

02/20/23

2D 3D TSV

198

MAP4K1 inhibitors

Blueprint Medicines Corporation

02/20/23

2D 3D TSV

39

Methods for treating depressive symptoms

ALKERMES PHARMA IRELAND LIMITED

02/20/23

2D 3D TSV

85

HGNC:8775 8774 8776

Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors

H. Lundbeck A/S

02/20/23

2D 3D TSV

10

Pyrrolo[1,2-b] pyridazine derivatives

Gilead Sciences, Inc.

02/20/23

2D 3D TSV

75

Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof

INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

02/20/23

2D 3D TSV

54

HGNC:3690 3689 3688

Bicyclic heterocycles as FGFR inhibitors

Incyte Holdings Corporation; Incyte Corporation

02/17/23

2D 3D TSV

228

Compositions and methods for treating CNS disorders

Sage Therapeutics, Inc.

02/17/23

2D 3D TSV

59

Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof

NURIX THERAPEUTICS, INC.

02/17/23

2D 3D TSV

382

Cyclic polypeptides for PCSK9 inhibition

Merck Sharp & Dohme LLC; Ra Pharmaceuticals, Inc.

02/17/23

2D 3D TSV

3

Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors

GENZYME CORPORATION

02/17/23

2D 3D TSV

17

Ligands to cereblon (CRBN)

DANA-FARBER CANCER INSTITUTE, INC.

02/17/23

2D 3D TSV

93

Naphthyridinone derivatives and their use in the treatment of arrhythmia

Novartis AG

02/17/23

2D 3D TSV

16

Small molecule inhibition of transcription factor SALL4 and uses thereof

DANA-FARBER CANCER INSTITUTE, INC.; THE BRIGHAM AND WOMEN''S HOSPITAL, INC.

02/17/23

2D 3D TSV

291

Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators

JANSSEN PHARMACEUTICA NV

02/17/23

2D 3D TSV

9

Use of known compounds as D-amino acid oxidase inhibitors

National Taiwan University; National Yang Ming Chiao Tung University; National Health Research Institutes

02/17/23

2D 3D TSV

431

2-(morpholin-4-yl)-1,7-naphthyridines

Bayer Pharma Aktiengesellschaft

02/16/23

2D 3D TSV

30

Alpha-5 beta-1 inhibitors

The Regents of the University of California; Shanghai ChemPartner Co., Ltd.

02/16/23

2D 3D TSV

45

HGNC:6866 30765

Analogs for the treatment of disease

Insilico Medicine IP Limited

02/16/23

2D 3D TSV

45

HGNC:6866 30765

Analogs for the treatment of disease

Insilico Medicine IP Limited

02/16/23

2D 3D TSV

63

Compositions and methods for treating infections

Vyera Pharmaceuticals, LLC

02/16/23

2D 3D TSV

31

Compounds

INFLAZOME LIMITED

02/16/23

2D 3D TSV

9

HGNC:549 6251

Imidazo[4,5-C]pyridine derived SSAO inhibitors

PROXIMAGEN, LLC

02/16/23

2D 3D TSV

123

Kinase inhibitors

The University of Manchester

02/16/23

2D 3D TSV

31

HGNC:3689 3688

Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists

Bristol-Myers Squibb Company

02/16/23

2D 3D TSV

17

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

SHAANXI PANLONG PHARMACEUTICAL CO., LTD.

02/16/23

2D 3D TSV

51

SHP2 phosphatase inhibitors and methods of use thereof

Relay Therapeutics, Inc.; D. E. Shaw Research, LLC

02/16/23

2D 3D TSV

61

Use of aminomethylenecyclohexane-1,3-dione compound

WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.

02/16/23

2D 3D TSV

717

Heterocyclic compound as a protein kinase inhibitor

HK inno.N Corporation

02/13/23

2D 3D TSV

14

HGNC:6190 6192 6193

JAK kinase inhibitor and preparation method and use thereof

SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD.

02/13/23

2D 3D TSV

31

Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)

Prelude Therapeutics, Incorporated

02/13/23

2D 3D TSV

7

HGNC:3430 3236

Alkyne substituted quinazoline compound and methods of use

Newgen Therapeutics, Inc.

02/12/23

2D 3D TSV

10

HGNC:6040 3236

Compounds for treating ILK-mediated diseases

The Cleveland Clinic Foundation

02/12/23

2D 3D TSV

1076

Indole and azaindole inhibitors of pad enzymes

Bristol-Myers Squibb Company

02/12/23

2D 3D TSV

310

Inhibitors of cysteine proteases and methods of use thereof

Pardes Biosciences, Inc.

02/12/23

2D 3D TSV

7

Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine

VTV THERAPEUTICS LLC

02/12/23

2D 3D TSV

15

Pyrazole compounds as LSD1 inhibitors and applications thereof

MEDSHINE DISCOVERY INC.

02/12/23

2D 3D TSV

58

CDPK1 inhibitors, compositions, and methods related thereto

Vyera Pharmaceuticals, LLC; Washington University

02/05/23

2D 3D TSV

11

Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

Kronos Bio, Inc.

02/05/23

2D 3D TSV

50

Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors

NIKANG THERAPEUTICS, INC.

02/05/23

2D 3D TSV

8

Inhibitors of DNMT1 as anticancer therapeutic agents

Victoria Link Limited; Albert Einstein College of Medicine

02/05/23

2D 3D TSV

15

MTOR inhibitor compounds

GALDERMA RESEARCH & DEVELOPMENT

02/05/23

2D 3D TSV

2

Macrocycle and composition comprising thereof

Shenzhen TargetRx, Inc.

02/05/23

2D 3D TSV

9

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

SHAANXI PANLONG PHARMACEUTICAL CO., LTD.

02/05/23

2D 3D TSV

10

Radiolabeled pharmaceuticals and methods of making and using same

YALE UNIVERSITY

02/05/23

2D 3D TSV

370

Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction

ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)

02/05/23

2D 3D TSV

59

Compounds useful in HIV therapy

GlaxoSmithKline Intellectual Property Development Limited; The University of North Carolina at Chapel Hill; ViiV Healthcare Company

01/31/23

2D 3D TSV

50

Aminocyclobutanes as monoacylglycerol lipase modulators

Janssen Pharmaceutica NV

01/28/23

2D 3D TSV

250

Anti-tumor effect potentiator using novel biphenyl compound

Taiho Pharmaceutical Co., Ltd.

01/28/23

2D 3D TSV

16

HGNC:9617 6524

BRK inhibitory compound

ONO PHARMACEUTICAL CO., LTD.

01/28/23

2D 3D TSV

102

CRBN ligands and uses thereof

KYMERA THERAPEUTICS, INC.

01/28/23

2D 3D TSV

139

Compounds and methods for the enhanced degradation of targeted proteins

Arvinas Operations, Inc.; Yale University

01/28/23

2D 3D TSV

1

Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof

Shenzhen TargetRx, Inc.

01/28/23

2D 3D TSV

107

Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases

Takeda Pharmaceutical Company Limited

01/28/23

2D 3D TSV

35

2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy

THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING

01/21/23

2D 3D TSV

3

HGNC:2637 2625 2623

Aryl-piperidine derivatives

Artax Biopharma Inc.

01/21/23

2D 3D TSV

76

Azaspirocycles as monoacylglycerol lipase modulators

Janssen Pharmaceutica NV

01/21/23

2D 3D TSV

159

Compounds and methods for treating oxalate-related diseases

OxaluRx, Inc.

01/21/23

2D 3D TSV

138

Dihydroorotate dehydrogenase inhibitors

TBA

01/21/23

2D 3D TSV

19

HGNC:4852 14064 19086 14063 13315 4854 4853 18128

HDAC8 inhibitors for treating cancer

CITY OF HOPE; TAIPEI MEDICAL UNIVERSITY; ACADEMIA SINICA

01/21/23

2D 3D TSV

62

HGNC:17663 18648 3590 3009

Inhibitors of fibroblast activation protein

PRAXIS BIOTECH LLC

01/21/23

2D 3D TSV

81

SSAO inhibitor

TBA

01/21/23

2D 3D TSV

3

HGNC:3430 6307 8804 3236

Tetrahydroquinoline derivatives and a process of preparation thereof

KING ABDULAZIZ UNIVERSITY

01/21/23

2D 3D TSV

30

Therapeutic compounds and methods of use thereof

LIGATURE THERAPEUTICS PTE. LTD.

01/21/23

2D 3D TSV

196

HGNC:8775 8774 8776

1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

H. Lundbeck A/S

01/20/23

2D 3D TSV

150

ACLY inhibitors and uses thereof

Nimbus Artemis, Inc.

01/20/23

2D 3D TSV

45

Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases

Janssen Sciences Ireland Unlimited Company

01/20/23

2D 3D TSV

120

HGNC:5275 17933

Benzisoxazole sulfonamide derivatives

Pfizer Inc.; CTXT PTY LTD

01/20/23

2D 3D TSV

23

Cyclic dinucleotides as sting agonists

Janssen Biotech, Inc.

01/20/23

2D 3D TSV

24

Cyclic peptide immunomodulators

Bristol-Myers Squibb Company

01/20/23

2D 3D TSV

54

Indazole compounds and uses thereof

Incyte Corporation

01/20/23

2D 3D TSV

320

MTA-cooperative PRMT5 inhibitors

Mirati Therapeutics, Inc.

01/20/23

2D 3D TSV

66

N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors

Nerviano Medical Sciences S.R.L.

01/20/23

2D 3D TSV

7

HGNC:8153 8154 8156

Peptides for treatment of medical disorders

Humanwell Pharmaceutical US

01/20/23

2D 3D TSV

4

Therapeutic methods and combinations

TBA

01/20/23

2D 3D TSV

2

Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase

Hanmi Pharm. Co., Ltd.

01/20/23

2D 3D TSV

153

HGNC:8975 3942

Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways

Neuropore Therapies, Inc.

01/20/23

2D 3D TSV

26

Azaindolylpyridone and diazaindolylpyridone compounds

Sprint Bioscience AB

01/17/23

2D 3D TSV

38

Dopamine D2 receptor ligands

The Broad Institute, Inc.; Massachusetts Institute of Technology

01/17/23

2D 3D TSV

152

Pyrimidine-fused cyclic compound, preparation method therefor and application thereof

BLUERAY THERAPEUTICS (SHANGHAI) CO., LTD

01/17/23

2D 3D TSV

275

Tricyclic heterocycles as BET protein inhibitors

Incyte Corporation; Incyte Holdings Corporation

01/17/23

2D 3D TSV

368

Amido spirocyclic amide and sulfonamide derivatives

Valo Health, Inc.; Genentech, Inc.

01/06/23

2D 3D TSV

137

Compounds and methods useful in the treatment of a PRMT5-mediated disorder

ARGONAUT THERAPEUTICS LIMITED

01/06/23

2D 3D TSV

140

Compounds for inhibiting TNIK and medical uses thereof

KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

01/06/23

2D 3D TSV

127

Compounds for treatment of PD-L1 diseases

ChemoCentryx, Inc.

01/06/23

2D 3D TSV

2

HGNC:10251 10252

Deuterated compounds as rock inhibitors

Fochon Pharmaceuticals, Ltd.

01/06/23

2D 3D TSV

82

HGNC:8153 8154 8156

Mu opioid receptor modulators

The Regents of the University of California; Friedrich-Alexander-Universität Erlangen-Nürnberg; The Board of Trustees of the Leland Stanford Junior University; The University of North Carolina at Chapel Hill

01/06/23

2D 3D TSV

35

N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators

Boehringer Ingelheim International GmbH

01/06/23

2D 3D TSV

222

Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors

MIRATI THERAPEUTICS, INC.

01/06/23

2D 3D TSV

121

Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors

KSQ Therapeutics, Inc.

01/06/23

2D 3D TSV

5

HGNC:2160 2159

Synthesis of (+)-cannabinoids and their therapeutic effects

SYMRISE AG

01/06/23

2D 3D TSV

222

2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor

HUTCHISON MEDIPHARMA LIMITED

12/30/22

2D 3D TSV

66

5-5 fused rings as C5a inhibitors

CHEMOCENTRYX, INC.

12/30/22

2D 3D TSV

6

5-aminolevulinate synthase inhibitors and methods of use thereof

University of South Florida

12/30/22

2D 3D TSV

486

Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors

CHEMOCENTRYX, INC.

12/30/22

2D 3D TSV

38

HGNC:9596 9595

EP4 antagonist

ONO PHARMACEUTICAL CO., LTD.

12/30/22

2D 3D TSV

49

Heterocyclic RIP1 kinase inhibitors

Rigel Pharmaceuticals, Inc.

12/30/22

2D 3D TSV

71

Inhibitors of Rho associated coiled-coil containing protein kinase

Kadmon Corporation, LLC

12/30/22

2D 3D TSV

321

MTA-cooperative PRMT5 inhibitors

Mirati Therapeutics, Inc.

12/30/22

2D 3D TSV

70

Macrocyclic chlorine substituted indole derivatives

Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.

12/30/22

2D 3D TSV

6

Method for treating inflammation

KING FAISAL UNIVERSITY

12/30/22

2D 3D TSV

225

OX2R compounds

TBA

12/30/22

2D 3D TSV

14

Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer

The Johns Hopkins University

12/30/22

2D 3D TSV

154

Small molecule modulators of the BTB domain of Keap1

MedImmune Limited

12/30/22

2D 3D TSV

4

Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase

Newave Pharmaceutical Inc.

12/30/22

2D 3D TSV

4

HGNC:4849 4848

Substituted piperidine compounds and their use

Eisai R&D Management Co., Ltd.

12/30/22

2D 3D TSV

5

Targeted drug rescue with novel compositions, combinations, and methods thereof

TBA

12/30/22

2D 3D TSV

24

Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors

Bristol-Myers Squibb Company

12/30/22

2D 3D TSV

94

HGNC:6307 9967

Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof

BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

12/30/22

2D 3D TSV

35

1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof

SOUTHERN MEDICAL UNIVERSITY

12/24/22

2D 3D TSV

27

HGNC:6251 4617

1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO—A.C.R.A.F. S.p.A.

12/24/22

2D 3D TSV

52

Acyclic antivirals

JANSSEN PHARMACEUTICA NV

12/24/22

2D 3D TSV

14

Cyclic dinucleotides as sting agonists

Janssen Biotech, Inc.

12/24/22

2D 3D TSV

111

HGNC:8775 8774 8776

Imidazopyrazinones as PDE1 inhibitors

H. Lundbeck A/S

12/24/22

2D 3D TSV

67

HGNC:11778 3531 11779 11777 16255

Inhibitors of blood coagulation factor XIII

Zedira GmbH

12/24/22

2D 3D TSV

172

Inhibitors of cysteine proteases and methods of use thereof

Pardes Biosciences, Inc.

12/24/22

2D 3D TSV

1

Mcl-1 inhibitors and methods of use thereof

AstraZeneca AB

12/24/22

2D 3D TSV

37

HGNC:6190 6192 6193 12440

Pyrazolo[1,5-a]pyrazin-4-yl derivatives

Pfizer Inc.

12/24/22

2D 3D TSV

186

HGNC:262 263 186

Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist

BEIGENE, LTD.

12/24/22

2D 3D TSV

79

Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors

Array BioPharma Inc.

12/24/22

2D 3D TSV

95

Tricyclic compounds and their use as phosphodiesterase inhibitors

PFIZER, INC.

12/24/22

2D 3D TSV

35

Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases

BEIGENE, LTD.

12/23/22

2D 3D TSV

11

Compounds for treatment of hypoproliferative disorders

LU LICENSE AB

12/23/22

2D 3D TSV

27

Diacylglycerol acyl transferase 2 inhibitor

Pfizer Inc.

12/23/22

2D 3D TSV

5

HGNC:2160 2159

Docosahexaenoic acid endocannabinoid epoxide derivative compositions

The Board of Trustees of the University of Illinois

12/23/22

2D 3D TSV

279

Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors

Incyte Corporation

12/23/22

2D 3D TSV

18

Quinazolinones that inhibit the formation of tau oligomers and their method of use

Oligomerix, Inc.

12/23/22

2D 3D TSV

93

RIP1 inhibitory compounds and methods for making and using the same

Rigel Pharmaceuticals, Inc.

12/23/22

2D 3D TSV

146

HGNC:6833 549 6834

SSAO inhibitors and use thereof

Eccogene (Shanghai) Co., Ltd.

12/23/22

2D 3D TSV

19

Sphingosine analogs and use thereof against bacterial lung infections

Yeda Research and Development Co. Ltd.; University of Duisburg-Essen

12/23/22

2D 3D TSV

51

3-substituted piperidine compounds for Cbl-b inhibition, and use thereof

Nurix Therapeutics, Inc.

12/11/22

2D 3D TSV

69

Compound functioning as bromodomain protein inhibitor, and composition

Betta Pharmaceuticals Co., Ltd.

12/11/22

2D 3D TSV

48

Compound having ERK kinase inhibitory activity and use thereof

SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

12/11/22

2D 3D TSV

10

Cyclic di-nucleotide compounds as sting agonists

Merck Sharp & Dohme LLC

12/11/22

2D 3D TSV

13

Heterocyclic compounds as immunomodulators

Incyte Corporation

12/11/22

2D 3D TSV

94

Heterocyclic inhibitors of PTPN11

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

12/11/22

2D 3D TSV

16

Modulators of the NMDA receptor

H. Lundbeck A/S

12/11/22

2D 3D TSV

60

Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof

SHANGHAI YINGLI PHARMACEUTICAL CO., LTD

12/11/22

2D 3D TSV

142

Pharmaceutical compounds

OTSUKA PHARMACEUTICAL CO., LTD.; TAIHO PHARMACEUTICAL CO., LTD.

12/11/22

2D 3D TSV

31

Pyridazines

Boehringer Ingelheim International GmbH

12/11/22

2D 3D TSV

187

HGNC:3023 5286

Substituted lactams showing serotonin 5-HT receptor activity

SUMITOMO PHARMA CO., LTD.

12/11/22

2D 3D TSV

21

Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors

Enanta Pharmaceuticals, Inc.

12/11/22

2D 3D TSV

27

Tricyclic compounds

JACOBIO PHARMACEUTICALS CO., LTD.

12/11/22

2D 3D TSV

15

HGNC:9605 385 9604 386

2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VANDERBILT UNIVERSITY

12/07/22

2D 3D TSV

286

HGNC:6514 6515

6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors

Novartis AG

12/07/22

2D 3D TSV

20

Annulated glycosidase inhibitors

Asceneuron SA

12/07/22

2D 3D TSV

30

Antibacterial compounds

INFEX Therapeutics Limited

12/07/22

2D 3D TSV

140

Biaryl derivative, preparation method thereof and pharmaceutical application thereof

ABBISKO THERAPEUTICS CO., LTD.

12/07/22

2D 3D TSV

72

Broad spectrum antiviral compositions and methods

Evrys Bio, LLC

12/07/22

2D 3D TSV

74

Broad spectrum inhibitors of filoviruses

Microbiotix, Inc.; Albert Einstein College of Medicine; The Government of the United States as Represented by the Secretary of the Army

12/07/22

2D 3D TSV

3

Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors

Suven Life Sciences Limited

12/07/22

2D 3D TSV

3

Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making

PHARMAKEA, INC.

12/07/22

2D 3D TSV

108

Heterocyclic compounds for the inhibition of PASK

BioEnergenix LLC

12/07/22

2D 3D TSV

71

Imidazopyridazine and imidazopyridine compounds and uses thereof

Incyte Corporation

12/07/22

2D 3D TSV

48

Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor

Chia Tai Tianqing Pharmaceutical Group Co., Inc.

12/07/22

2D 3D TSV

227

Modulators of methyl modifying enzymes, compositions and uses thereof

Constellation Pharmaceuticals, Inc.

12/07/22

2D 3D TSV

160

N/O-linked Degrons and Degronimers for protein degradation

C4 Therapeutics, Inc.

12/07/22

2D 3D TSV

67

Pyrazine carbamates and their use as GluN2B receptor modulators

JANSSEN PHARMACEUTICA NV

12/07/22

2D 3D TSV

5

HGNC:6190 6192 6193 12440

Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors

VIMALAN BIOSCIENCES, INC.

12/07/22

2D 3D TSV

229

TEAD inhibitors and uses thereof

IKENA ONCOLOGY, INC.

12/07/22

2D 3D TSV

36

Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors

NIKANG THERAPEUTICS, INC.

12/07/22

2D 3D TSV

15

3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

MINDSET PHARMA INC.

12/04/22

2D 3D TSV

215

Cyclic di-nucleotide compounds as sting agonists

Merck Sharp & Dohme LLC

12/04/22

2D 3D TSV

25

HGNC:6190 6192 6193 12440

JAK inhibitors containing a 4-membered heterocyclic amide

THERAVANCE BIOPHARMA R&D IP, LLC

12/04/22

2D 3D TSV

452

KRas G12D inhibitors

MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA INC.

12/04/22

2D 3D TSV

143

HGNC:336 338

Receptor inhibitor, pharmaceutical composition comprising same, and use thereof

BEIJING TIDE PHARMACEUTICAL CO., LTD.

12/04/22

2D 3D TSV

576

Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

12/04/22

2D 3D TSV

16

HGNC:8783 8775 8774 8776 8778

Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors

ELI LILLY AND COMPANY

12/04/22

2D 3D TSV

72

Substituted eneoxindoles and uses thereof

Gilead Sciences, Inc.

12/04/22

2D 3D TSV

44

Substituted propanamides as inhibitors of nucleases

MASARYKOVA UNIVERZITA

12/04/22

2D 3D TSV

1

HGNC:8031 8032 8033

Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors

SHENZHEN TARGETRX, INC.

12/04/22

2D 3D TSV

29

Tricyclic compounds useful to treat orthomyxovirus infections

Novartis AG

12/04/22

2D 3D TSV

4

HGNC:1509 1504 1499 1511

(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases

Histogen, Inc.

11/20/22

2D 3D TSV

66

Galactoside inhibitor of galectins

GALECTO BIOTECH AB

11/20/22

2D 3D TSV

49

Macrocyclic chlorine substituted indole derivatives

Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.

11/20/22

2D 3D TSV

225

HGNC:1738 1737 10251 10252

Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer

Cancer Research Technology Limited

11/20/22

2D 3D TSV

12

Tricyclic amine compounds as CDK2 inhibitors

Incyte Corporation

11/20/22

2D 3D TSV

360

Aminoimidazopyridazines as kinase inhibitors

Bristol-Myers Squibb Company

11/19/22

2D 3D TSV

116

Anti-inflammatory compound, and preparation and use thereof

E-Nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.

11/19/22

2D 3D TSV

25

Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof

SHANGHAI YINGLI PHARMACEUTICAL CO., LTD

11/19/22

2D 3D TSV

83

Compound exhibiting enteropeptidase inhibitory activity

LG CHEM, LTD.

11/19/22

2D 3D TSV

90

Compounds, salts thereof and methods for treatment of diseases

ACADIA PHARMACEUTICALS INC.

11/19/22

2D 3D TSV

64

Cyclic compound having dopamine D3 receptor antagonistic effect

SHIONOGI & CO., LTD.

11/19/22

2D 3D TSV

10

Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof

Korea Research Institute of Chemical Technology; Industry-Academic Cooperation Foundation, Yonsei University

11/19/22

2D 3D TSV

32

Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors

Recordati Industria Chimica e Farmacentica S.p.A.

11/19/22

2D 3D TSV

33

Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof

HINOVA PHARMACEUTICALS INC.

11/19/22

2D 3D TSV

95

Inhibitors of cyclin-dependent kinases

TBA

11/19/22

2D 3D TSV

118

Pharmaceutical compounds for treatment of medical disorders

Achillion Pharmaceuticals, Inc.

11/19/22

2D 3D TSV

46

HGNC:6190 6192 6193 12440

Pyrimidine JAK inhibitors for the treatment of skin diseases

THERAVANCE BIOPHARMA R&D IP, LLC

11/19/22

2D 3D TSV

98

HGNC:11584 14552

Pyrimidine TBK/IKKe inhibitor compounds and uses thereof

Merck Patent GmbH

11/19/22

2D 3D TSV

7

Quinoline analogs as phosphatidylinositol 3-kinase inhibitors

NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD.

11/19/22

2D 3D TSV

5

Selective A2A receptor antagonist

INXMED (NANJING) CO., LTD.

11/19/22

2D 3D TSV

94

Spiroheptanyl hydantoins as rock inhibitors

Bristol-Myers Squibb Company

11/19/22

2D 3D TSV

6

Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity

The Board of Trustees of the Leland Stanford Junior University

11/19/22

2D 3D TSV

79

Substituted macrocyclic indole derivatives

TBA

11/19/22

2D 3D TSV

30

HGNC:6877 1079 1133 6171 9611 3236

Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof

TBA

11/19/22

2D 3D TSV

353

Tetrahydroquinoline derivatives as P2X7 receptor antagonists

RaQualia Pharma Inc.; Asahi Kasei Pharma Corporation

11/19/22

2D 3D TSV

22

Triazolo-azepine derivatives

Hoffmann-La Roche Inc.

11/19/22

2D 3D TSV

32

Tricyclic amine compounds as CDK2 inhibitors

Incyte Corporation

11/19/22

2D 3D TSV

10

p38α mitogen-activated protein kinase inhibitors

GEN1E LIFESCIENCES INC.

11/19/22

2D 3D TSV

12

ASK1 inhibitor compounds and uses thereof

SEAL ROCK THERAPEUTICS, INC.

11/13/22

2D 3D TSV

56

ATR inhibitor and application thereof

Wuxi Biocity Biopharmaceutics Co., Ltd.

11/13/22

2D 3D TSV

129

Heterocyclic inhibitors of ATR kinase

Board of Regents, The University of Texas System; ChemPartner Corporation

11/13/22

2D 3D TSV

359

Heterocyclylamines as PI3K inhibitors

Incyte Corporation; Incyte Holdings Corporation

11/13/22

2D 3D TSV

164

LSD1 inhibitor and preparation method and application thereof

MEDSHINE DISCOVERY INC.

11/13/22

2D 3D TSV

70

PDE9 inhibitor and use thereof

Nanjing TransThera Biosciences Co. Ltd.

11/13/22

2D 3D TSV

17

Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

Genentech, Inc.

11/13/22

2D 3D TSV

166

HGNC:6192 12440

TYK2 inhibitors and uses thereof

Nimbus Lakshmi, Inc.

11/13/22

2D 3D TSV

70

HGNC:6190 9380 6192 5960 6193 10251 9399 12440 10252 11366

Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Aerie Pharmaceuticals, Inc.

11/07/22

2D 3D TSV

69

Bromodomain inhibitor compound and use thereof

Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Suzhou Suplead Life Sciences Co., Ltd.

11/07/22

2D 3D TSV

124

HGNC:11408 11406

Composition and methods for inhibiting mammalian sterile 20-like kinase 1

THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN

11/07/22

2D 3D TSV

8

Cycloalkyl-diamines for the treatment of inflammation

MediSynergics, LLC

11/07/22

2D 3D TSV

291

HGNC:8779 8778

Dihydrooxadiazinones

Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.

11/07/22

2D 3D TSV

40

IRAK4 inhibiting agents

BIOGEN MA INC.

11/07/22

2D 3D TSV

84

Imidazo-pyridine compounds as PAD inhibitors

JUBILANT EPIPAD LLC

11/07/22

2D 3D TSV

465

Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors

Incyte Corporation

11/07/22

2D 3D TSV

312

Immunomodulator compounds

ChemoCentryx, Inc.

11/07/22

2D 3D TSV

332

Indazoles and azaindazoles as LRRK2 inhibitors

ESCAPE Bio, Inc.

11/07/22

2D 3D TSV

543

Inhibitors of KEAP1-Nrf2 protein-protein interaction

Janssen Pharmaceutica NV

11/07/22

2D 3D TSV

22

HGNC:6190 6192 6193 12440

JAK inhibitor and use thereof

ZHUHAI UNITED LABORATORIES CO., LTD.

11/07/22

2D 3D TSV

13

Kinase inhibitors

Insilico Medicine IP Limited

11/07/22

2D 3D TSV

24

HGNC:3763 14661

Prolyl hydroxylase inhibitors and methods of use

Akebia Therapeutics, Inc.

11/07/22

2D 3D TSV

4

Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders

Mindset Pharma Inc.

11/07/22

2D 3D TSV

84

Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases

The Johns Hopkins University; Institute of Organic Chemistry & Biochemistry

11/07/22

2D 3D TSV

228

Substituted pyrrolopyridine-derivatives

Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft; Deutsches Krebsforschungszentrum

11/07/22

2D 3D TSV

1

Substituted quinolines useful as kinase inhibitors

Teligene Ltd.

11/07/22

2D 3D TSV

22

HGNC:270 272

4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors

NERVIANO MEDICAL SCIENCES S.R.L.

11/06/22

2D 3D TSV

208

HGNC:15633 15631 15632

Amide substituted indole compounds useful as TLR inhibitors

Bristol-Myers Squibb Company

11/06/22

2D 3D TSV

29

HGNC:663 664

Arginase inhibitors and methods of use thereof

AstraZeneca AB

11/06/22

2D 3D TSV

452

HGNC:15633 15631 15632

Aryl and heteroaryl substituted indole compounds

Bristol-Myers Squibb Company

11/06/22

2D 3D TSV

589

HGNC:992 2623 990

Bcl-2 inhibitors

BEIGENE, LTD.

11/06/22

2D 3D TSV

150

Bicyclic compounds

VIVACE THERAPEUTICS, INC.

11/06/22

2D 3D TSV

18

Compounds as neuronal histamine receptor-3 antagonists and uses thereof

XWPHARMA LTD.

11/06/22

2D 3D TSV

26

DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof

Yunnan University; Kunming Institute of Zoology, Chinese Academy of Sciences

11/06/22

2D 3D TSV

145

Dosage forms and regimens for amino acid compounds

Pliant Therapeutics, Inc.

11/06/22

2D 3D TSV

67

Heterocyclic compounds as anti-viral agents

ENANTA PHARMACEUTICALS, INC.

11/06/22

2D 3D TSV

16

Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases

NIKANG THERAPEUTICS, INC.

11/06/22

2D 3D TSV

316

Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents

NOVARTIS AG

11/06/22

2D 3D TSV

39

Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors

TRANSTHERA SCIENCES (NANJING), INC.

11/06/22

2D 3D TSV

67

HGNC:6190 6192 6193

Substituted pyrrolopyridines as JAK inhibitors

TBA

11/06/22

2D 3D TSV

30

Treatment of tachycardia

OSLO UNIVERSITY HOSPITAL HF

11/06/22

2D 3D TSV

53

AMPK activators

KALLYOPE, INC.

11/05/22

2D 3D TSV

22

Tryptophan hydroxylase inhibitor and pharmaceutical composition including same

Gwangju Institute of Science and Technolgy; Korea Advanced Institute of Science and Technology; KyungPook National University Industry-Academic Cooperation Foundation; Curacle Co., LTD.

11/05/22

2D 3D TSV

149

Compounds and uses thereof

Foghorn Therapeutics Inc.

10/30/22

2D 3D TSV

78

Compounds for the treatment of BRAF-associated diseases and disorders

Array BioPharma Inc.

10/30/22

2D 3D TSV

5

Compounds useful as immunomodulators

Bristol-Myers Squibb Company

10/30/22

2D 3D TSV

97

Formulations of Tie-2 activators and methods of use thereof

EYEPOINT PHARMACEUTICALS, INC.

10/30/22

2D 3D TSV

55

HGNC:6190 6192 6193

Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof

Suzhou Longbiotech Pharmaceuticals Co., Ltd.

10/30/22

2D 3D TSV

66

Heterocyclic compounds as immunomodulators

Incyte Corporation

10/30/22

2D 3D TSV

136

Heterocyclic compounds as modulators of mGluR7

Pragma Therapeutics

10/30/22

2D 3D TSV

212

HGNC:6190 6192 6193 11491

Inhibitors of protein kinases

Alexion Pharmaceuticals, Inc.

10/30/22

2D 3D TSV

19

Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy

Auckland UniServices Limited

10/30/22

2D 3D TSV

103

Oxoacridinyl acetic acid derivatives and methods of use

STINGTHERA, INC.

10/30/22

2D 3D TSV

379

P300/CBP hat inhibitors

Constellation Pharmaceuticals, Inc.

10/30/22

2D 3D TSV

1022

Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors

Nimbus Lakshmi, Inc.

10/30/22

2D 3D TSV

37

Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors

MISSION THERAPEUTICS LIMITED

10/30/22

2D 3D TSV

6

Acetamide thienotriazolodiazepines and uses thereof

Dana-Farber Cancer Institute, Inc.

10/28/22

2D 3D TSV

58

Antibacterial compounds

FORGE THERAPEUTICS, INC.

10/28/22

2D 3D TSV

121

Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders

Achillion Pharmaceuticals, Inc.

10/28/22

2D 3D TSV

80

CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer

AMGEN INC.

10/28/22

2D 3D TSV

3

HGNC:3690 3689 3688

Derivatives of an FGFR inhibitor

Incyte Corporation

10/28/22

2D 3D TSV

36

HGNC:6307 7029

Dioxinoquinoline compounds, preparation method and uses thereof

BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED

10/28/22

2D 3D TSV

114

HGNC:7027 7029

Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors

Development Center for Biotechnology

10/28/22

2D 3D TSV

27

Heterocyclic compounds as immunomodulators

Incyte Corporation

10/28/22

2D 3D TSV

85

Inhibitors of RAF kinases

KINNATE BIOPHARMA INC.

10/28/22

2D 3D TSV

26

JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction

Incyte Corporation

10/28/22

2D 3D TSV

118

HGNC:6875 6876

Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof

Washington University

10/28/22

2D 3D TSV

16

Pyrazolopyridine compounds and uses thereof

Incyte Corporation

10/28/22

2D 3D TSV

208

RIP1 inhibitory compounds and methods for making and using the same

Rigel Pharmaceuticals, Inc.

10/28/22

2D 3D TSV

13

HGNC:1133 6193

Substituted piperidines as kinase inhibitors

Daewoong Pharmaceutical Co., Ltd.

10/28/22

2D 3D TSV

13

Treatment of upper aerodigestive tract disorders and cough

TBA

10/28/22

2D 3D TSV

79

HGNC:8031 8032 8033

Tropomyosin-related kinase (TRK) inhibitors

Genzyme Corporation

10/28/22

2D 3D TSV

22

1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2

NOVARTIS AG

10/23/22

2D 3D TSV

153

HGNC:11048 1399

Alcoxyamino derivatives for treating pain and pain related conditions

ESTEVE PHARMACEUTICALS, S.A.

10/23/22

2D 3D TSV

1

Biochemical binding of RET9 and VEGFR2 inhibitors

Kala Pharmaceuticals, Inc.

10/23/22

2D 3D TSV

23

Cyclic dinucleotide compound and uses thereof

SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.; JIANGXI JEMINCARE GROUP CO., LTD.

10/23/22

2D 3D TSV

64

Dihydroquinolinones for medical treatment

C4 Therapeutics, Inc.

10/23/22

2D 3D TSV

307

Heteroaryl inhibitors of PDE4

Tetra Discovery Partners, LLC

10/23/22

2D 3D TSV

138

Heterocyclic compounds as LSD1 inhibitors

Incyte Corporation

10/23/22

2D 3D TSV

11

Isoquinoline derivatives and use thereof

Purdue Pharma L.P.

10/23/22

2D 3D TSV

62

Macrocyclic indole derivatives

The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft

10/23/22

2D 3D TSV

40

Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Incyte Corporation

10/23/22

2D 3D TSV

81

HGNC:8978 8975 8977 8976

Pyrimidinones as PI3K inhibitors

Incyte Holdings Corporation; Incyte Corportion

10/23/22

2D 3D TSV

41

Small molecule activators of Parkin enzyme function

Mayo Foundation for Medical Education and Research

10/23/22

2D 3D TSV

8

HGNC:8783 8775 8774 8776 8778

[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes

ELI LILLY AND COMPANY

10/23/22

2D 3D TSV

23

1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

10/17/22

2D 3D TSV

34

Amine compound for inhibiting SSAO/VAP-1 and use thereof

SUNSHINE LAKE PHARMA CO., LTD.

10/17/22

2D 3D TSV

15

Amino acid compounds with unbranched linkers and methods of use

Pliant Therapeutics, Inc.

10/17/22

2D 3D TSV

21

Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor

CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

10/17/22

2D 3D TSV

479

Benzodiazepine derivatives as RSV inhibitors

Enanta Pharmaceuticals, Inc.

10/17/22

2D 3D TSV

218

HGNC:1771 1777

CDK2/4/6 inhibitors

Pfizer Inc.

10/17/22

2D 3D TSV

45

HGNC:8978 8977

Substituted heterocyclic derivatives as PI3K inhibitors

Incyte Corporation

10/17/22

2D 3D TSV

601

TYK2 inhibitors and uses thereof

Nimbus Lakshmi, Inc.

10/17/22

2D 3D TSV

2

HGNC:2595 17450 2615 2625

Tricyclic compounds as Cyp1 inhibitors

The General Hospital Corporation

10/17/22

2D 3D TSV

267

1-cyano-pyrrolidine compounds as USP30 inhibitors

Mission Therapeutics Limited

10/16/22

2D 3D TSV

66

HGNC:663 664

Arginase inhibitors as therapeutics

Mars, Incorporated

10/16/22

2D 3D TSV

104

Compounds and methods for treating oxalate-related diseases

OxaluRx, Inc.

10/16/22

2D 3D TSV

34

Compounds for targeting mutant huntingtin protein and uses thereof

CHDI Foundation, Inc.

10/16/22

2D 3D TSV

159

Inhibitors of cyclin-dependent kinases

KINNATE BIOPHARMA INC.

10/16/22

2D 3D TSV

7

Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof

Beijing Innocare Pharma Tech Co., Ltd.

10/16/22

2D 3D TSV

215

Piperazine derivatives as MAGL inhibitors

Hoffmann-La Roche Inc.

10/16/22

2D 3D TSV

47

HGNC:263 264

Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors

Incyte Corporation

10/16/22

2D 3D TSV

314

HGNC:10251 10252

Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof

BEIJING TIDE PHARMACEUTICAL CO., LTD.

10/16/22

2D 3D TSV

38

Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application

GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

10/09/22

2D 3D TSV

1

Diphenylaminopyrimidine compound for inhibiting kinase activity

Shenzhen TargetRx, Inc.

10/09/22

2D 3D TSV

20

Heterocyclic compound as CSF-1R inhibitor and use thereof

MEDSHINE DISCOVERY INC.

10/09/22

2D 3D TSV

45

Heterocyclic compounds useful as aurora a selective inhibitors

Jacobio Pharmaceuticals Co., Ltd.

10/09/22

2D 3D TSV

120

Spiropyrrolidine derived antiviral agents

Enanta Pharmaceuticals, Inc.

10/09/22

2D 3D TSV

7

Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors

UNION therapeutics A/S

10/09/22

2D 3D TSV

19

Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors

Incyte Corporation

10/09/22

2D 3D TSV

209

2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors

Merck Sharp & Dohme LLC

10/06/22

2D 3D TSV

132

CD73 inhibitors

ORIC PHARMACEUTICALS, INC.

10/06/22

2D 3D TSV

106

Galactoside inhibitor of galectins

Galecto Biotech AB

10/06/22

2D 3D TSV

164

Heterocyclic prolinamide derivatives

ORION OPHTHALMOLOGY LLC

10/06/22

2D 3D TSV

41

Acetyl-CoA carboxylase modulators

Monsanto Technology LLC

10/05/22

2D 3D TSV

20

Inhibiting mutant IDH-1

FORMA Therapeutics, Inc.

10/05/22

2D 3D TSV

56

Inhibitors of RAF kinases

KINNATE BIOPHARMA INC.

10/05/22

2D 3D TSV

19

HGNC:4852 4854 4853

Inhibitors of histone deacetylase

The Broad Institute, Inc.; The General Hospital Corporation

10/05/22

2D 3D TSV

34

Purine derivatives and the use thereof as medicament

Boehringer Ingelheim International GmbH

10/05/22

2D 3D TSV

94

RIP1 inhibitory compounds and methods for making and using the same

Rigel Pharmaceuticals, Inc.

10/05/22

2D 3D TSV

177

Serine/threonine kinase inhibitors

Genentech, Inc.

10/05/22

2D 3D TSV

32

HGNC:6888 6844 6889 6879 6880 6871 6887

3-arylindazoles as selective MEK4 inhibitors

NORTHWESTERN UNIVERSITY

09/25/22

2D 3D TSV

10

Antimalarial compounds, process for preparation and their use for drug resistant malaria

Council of Scientific and Industrial Research; International Centre for Genetic Engineering and Biotechnology (ICGEB)

09/25/22

2D 3D TSV

229

Compounds

TMEM16A LIMITED

09/25/22

2D 3D TSV

23

HGNC:20581 2603

Compounds and methods for inhibiting CPY26 enzymes

Queen''s University at Kingston

09/25/22

2D 3D TSV

54

Compounds that inhibit Mcl-1 protein

AMGEN INC.

09/25/22

2D 3D TSV

549

Compounds useful as inhibitors of ATR kinase

VERTEX PHARMACEUTICALS INCORPORATED

09/25/22

2D 3D TSV

92

Cyano-substituted heterocycles with activity as inhibitors of USP30

MISSION THERAPEUTICS LIMITED

09/25/22

2D 3D TSV

79

HGNC:6307 3690 3691 3689 3688

FGFR inhibitor and application thereof

Betta Pharmaceuticals Co., Ltd.

09/25/22

2D 3D TSV

598

GLS1 inhibitors for treating disease

Board of Regents, The University of Texas System

09/25/22

2D 3D TSV

21

Heteroaryl plasma kallikrein inhibitors

Takeda Pharmaceutical Company Limited

09/25/22

2D 3D TSV

60

Heterocyclic inhibitors of tyrosine kinase

Board of Regents, The University of Texas System

09/25/22

2D 3D TSV

124

Imidazolidin-2-one compounds as PRMT5 modulators

AURIGENE DISCOVERY TECHNOLOGIES LIMITED

09/25/22

2D 3D TSV

27

HGNC:3166 14298

Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds

Eli Lilly and Company

09/25/22

2D 3D TSV

365

Melt-extruded solid dispersions containing an apoptosis-inducing agent

AbbVie Inc.; AbbVie Deutschland GMBH & Co KG

09/25/22

2D 3D TSV

10

Optically active azabicyclo ring derivative

Sumitomo Dainippon Pharma Co., Ltd.

09/25/22

2D 3D TSV

17

P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof

SHANGHAI ZHIMENG BIOPHARMA INC.

09/25/22

2D 3D TSV

47

Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer

PELEMED CO., LTD.

09/25/22

2D 3D TSV

5

HGNC:8795 8774

Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one

Imara Inc.

09/25/22

2D 3D TSV

447

Pyridine compound substituted with azole

TAISHO PHARMACEUTICAL CO., LTD.

09/25/22

2D 3D TSV

94

RIP1 inhibitory compounds and methods for making and using the same

Rigel Pharmaceuticals Inc.

09/25/22

2D 3D TSV

14

Substituted benzimidazoles, their preparation and their use as pharmaceuticals

EPIGENETIX, INC.

09/25/22

2D 3D TSV

528

Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors

BioCryst Pharmaceuticals, Inc.

09/25/22

2D 3D TSV

185

Substituted cyclohexyl compounds as NOP inhibiiors

Dart NeuroScience, LLC

09/25/22

2D 3D TSV

73

HGNC:11892 8783

Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors

Union therapeutics A/S

09/25/22

2D 3D TSV

62

Substituted pyrazoles as LRRK2 inhibitors

OSCOTEC INC.

09/25/22

2D 3D TSV

7

Therapeutic compounds and uses thereof

Kala Pharmaceuticals, Inc.

09/25/22

2D 3D TSV

31

CRBN ligands and uses thereof

KYMERA THERAPEUTICS, INC.

09/19/22

2D 3D TSV

9

HGNC:20581 2603

Compounds and methods for inhibiting CYP26 enzymes

Queen''s University at Kingston

09/19/22

2D 3D TSV

29

Functionalized peptides as antiviral agents

Enanta Pharmaceuticals, Inc.

09/19/22

2D 3D TSV

102

Lysyl oxidase-like 2 inhibitors and uses thereof

PharmAkea, Inc.

09/19/22

2D 3D TSV

12

Prodrugs of modulators of the NMDA receptor

H. Lundbeck A/S

09/19/22

2D 3D TSV

56

HGNC:6307 9967

Compounds useful as RET inhibitors

Cancer Research Technology Limited

09/11/22

2D 3D TSV

122

Spiropyrrolidine derived antiviral agents

Enanta Pharmaceuticals, Inc.

09/11/22

2D 3D TSV

305

TGF-beta inhibitors

Rigel Pharmaceuticals, hic.; Bristol-Myers Squibb Company

09/11/22

2D 3D TSV

198

1-cyano-pyrrolidine derivatives as DUB inhibitors

MISSION THERAPEUTICS LIMITED

09/10/22

2D 3D TSV

261

HGNC:1079 1133 6193 6171 3236

2,4-disubstituted pyrimidines useful as kinase inhibitors

Celgene CAR LLC

09/10/22

2D 3D TSV

163

HGNC:29079 14064

Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors

Jubilant Epicore LLC

09/10/22

2D 3D TSV

347

HIV protease inhibitors

Gilead Sciences, Inc.

09/10/22

2D 3D TSV

324

Inhibitors of plasma kallikrein and uses thereof

Takeda Pharmaceutical Company Limited

09/10/22

2D 3D TSV

89

Nitrile-containing antiviral compounds

Pfizer Inc.

09/10/22

2D 3D TSV

210

Phenoxymethyl derivatives

Hoffmann-La Roche Inc.

09/10/22

2D 3D TSV

281

HGNC:8978 8977

Pyridine and pyridimine compounds as PI3K-gamma inhibitors

Incyte Corporation

09/10/22

2D 3D TSV

33

Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof

Xiamen University

09/10/22

2D 3D TSV

16

HGNC:1771 1777 1774 1773

Substituted pyrimidines as CDK4/6 inhibitors

Beijing Xuanyi PharmaSciences Co., Ltd.

09/10/22

2D 3D TSV