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Patent
Data
Cmpds
HGNC*
Patent Title
Organization
Deposition
Downloads
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20
6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
Purdue Research Foundation
05/11/23
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1533
Aminopyrrolotriazines as kinase inhibitors
Bristol-Myers Squibb Company
05/11/23
-
186
Benzoimidazoles as prolyl hydroxylase inhibitors
Janssen Pharmaceutica NV
05/11/23
-
18
Compounds active towards nuclear receptors
NUEVOLUTION A/S
05/10/23
-
19
Heterocyclic compounds as immunomodulators
Incyte Corporation
05/10/23
-
36
Oxysterols and methods of use thereof
SAGE THERAPEUTICS, INC.
05/10/23
-
83
Substituted pyridotriazine compounds and uses thereof
Gilead Sciences, Inc.
05/10/23
-
24
3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
05/09/23
-
302
8-aminoisoquinoline compounds and uses thereof
Genentech, Inc.
05/09/23
-
116
Enzyme inhibitors
KalVista Pharmaceuticals Limited
05/09/23
-
123
Glycosidase inhibitors
Asceneuron SA
05/09/23
-
167
Inhibitors of RHO associated coiled-coil containing protein kinase
Kadmon Corporation, LLC
05/09/23
-
10
Pharmaceutical formulations comprising CCR3 antagonists
Alkahest, Inc.
05/09/23
-
62
Substituted condensed thiophenes as modulators of sting
CTXT PTY LIMITED
05/09/23
-
22
Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
05/05/23
-
106
Bicyclic amide compounds and methods of use thereof
Genentech, Inc.
05/05/23
-
9
Curcumin analogues as zinc chelators and their uses
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; CHEM-MASTER INTERNATIONAL INC.
05/05/23
-
42
FGFR4 inhibitor and preparation method and use thereof
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
05/05/23
-
40
Heterocyclic compounds as immunomodulators
Incyte Corporation
05/05/23
-
138
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent GmbH
05/05/23
-
161
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
05/05/23
-
93
Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
Hoffmann-La Roche Inc.
05/05/23
-
5
PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
H. Lundbeck A/S
05/05/23
-
19
Compounds and therapeutic uses thereof
VioGen Biosciences, LLC
04/30/23
-
64
MTORC1 modulators and uses thereof
Aeovian Pharmaceuticals, Inc.
04/30/23
-
285
PCSK9 inhibitors and methods of use thereof
AstraZeneca AB
04/30/23
-
34
Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
Array BioPharma Inc.
04/30/23
-
19
Compounds and compositions for the treatment of parasitic diseases
Novartis AG
04/23/23
-
53
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
04/23/23
-
10
Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
04/23/23
-
26
JAK1 pathway inhibitors for the treatment of gastrointestinal disease
Incyte Corporation
04/23/23
-
429
Monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
04/23/23
-
20
PD-L1/STING conjugates and methods of use
Incyte Corporation
04/23/23
-
4
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
MINDSET PHARMA INC.
04/23/23
-
3
SHP2 inhibitor compositions and methods for treating cancer
Revolution Medicines, Inc.
04/23/23
-
719
Substituted indole Mcl-1 inhibitors
Vanderbilt University
04/23/23
-
28
Benzamide compounds
Recurium IP Holdings, LLC
04/14/23
-
26
Bicyclic heterocycles as FGFR inhibitors
Incyte Corporation
04/14/23
-
13
Bipyrazole derivatives as JAK inhibitors
Incyte Corporation
04/14/23
-
27
Certain chemical compositions and methods of use thereof
Algen Biotechnologies, Inc.
04/14/23
-
164
Compounds, compositions, and methods
Denali Therapeutics Inc.
04/14/23
-
46
Heterocyclic compound, application thereof and pharmaceutical composition comprising same
SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.
04/14/23
-
26
Highly active CSF1R inhibitor compound
XIAMEN BIOTIME BIOTECHNOLOGY CO., LTD.
04/14/23
-
25
Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
HINOVA PHARMACEUTICALS INC.
04/14/23
-
40
Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof
STINGRAY THERAPEUTICS, INC.
04/14/23
-
73
Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
Pharmablock Sciences (Nanjing), Inc.
04/14/23
-
14
Oxazolidinone antibiotic compounds and process of preparation
BUGWORKS RESEARCH, INC.
04/14/23
-
99
PARP1 inhibitors and uses thereof
XINTHERA, INC.
04/14/23
-
3
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma Inc.
04/14/23
-
144
Pyrrolotriazine compounds as TAM inhibitors
Incyte Corporation
04/14/23
-
51
Small molecule inducers of autophagy
Board of Regents, The University of Texas System
04/14/23
-
514
Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
D. E. Shaw Research, LLC; Relay Therapeutics, Inc.
04/14/23
-
4
Amino alcohol derivative, pharmaceutical composition and application thereof
BEIJING FORELAND PHARMA CO., LTD.
04/09/23
-
15
Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
04/09/23
-
6
Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
STEALTH BIOTHERAPEUTICS INC.
04/09/23
-
13
Dash inhibitors, and uses related thereto
Trustees of Tufts College
04/09/23
-
165
Dihydrothieno[3,2-b]pyridine compounds
IDEAYA BIOSCIENCES, INC.
04/09/23
-
33
Heterocyclic compounds as BET inhibitors
NUVATION BIO INC.
04/09/23
-
27
Inhibitors of EGFR and methods of use thereof
Dana-Farber Cancer Institute, Inc.
04/09/23
-
479
MASP-2 inhibitors and methods of use
OMEROS CORPORATION
04/09/23
-
22
Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
Heptares Therapeutics Limited
04/09/23
-
57
RIP1K inhibitors
Rigel Pharmaceuticals, Inc.
04/09/23
-
2
Solid forms of a plasma kallikrein inhibitor and salts thereof
KalVista Pharmaceuticals Limited
04/09/23
-
80
Spirocyclic compounds
C4 Therapeutics, Inc.
04/09/23
-
225
Substituted pyridopyrimidinonyl compounds useful as T cell activators
TBA
04/09/23
-
145
Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
VENENUM BIODESIGN, LLC
04/09/23
-
73
Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors
Boehringer Ingelheim International GmbH
04/09/23
-
21
Compounds useful as immunomodulators
Bristol-Myers Squibb Company
03/31/23
-
227
Condensed ring compounds having dopamine D3 receptor antagonistic effect
Shionogi & Co., Ltd.
03/31/23
-
289
Fluoroalkyl-oxadiazoles and uses thereof
Tenaya Therapeutics, Inc.
03/31/23
-
22
Heterocyclic RIP1 inhibitory compounds
Rigel Pharmaceuticals, Inc.
03/31/23
-
3
Heterocyclic compounds for inhibiting TYK2 activities
Beijing Innocare Pharma Tech Co.
03/31/23
-
20
Inhibiting mutant IDH-1
FORMA Therapeutics, Inc.
03/31/23
-
282
Inhibitors of LRRK2 kinase
HALIA THERAPEUTICS, INC.
03/31/23
-
72
Spiro-oxazolones
Hoffmann-La Roche Inc.
03/31/23
-
64
Therapeutic agent for non-motor symptoms associated with Parkinson's disease
Sumitomo Pharma Co., Ltd.
03/31/23
-
23
Thienopyrimidones
Boehringer Ingelheim International GmbH
03/31/23
-
29
Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
Beijing Innocare Pharma Tech Co., Ltd.
03/26/23
-
44
Antibacterial agents: arylalkylcarboxamido phloroglucinols
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
03/26/23
-
4
BRD4 inhibitor
HINOVA PHARMACEUTICALS INC.
03/26/23
-
14
Cyanoaryl-aniline compounds for treatment of dermal disorders
NFLECTION THERAPEUTICS, INC.
03/26/23
-
40
Heterocyclic compounds as immunomodulators
Incyte Corporation
03/26/23
-
26
Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
University Health Network
03/26/23
-
171
Inhibitors of histone deacetylase
The General Hospital Corporation; The Broad Institute, Inc.; Massachusetts Institute of Technology
03/26/23
-
452
N-cyano-7-azanorbornane derivatives and uses thereof
AMGEN INC.
03/26/23
-
38
Pyrazine compounds and uses thereof
DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD.
03/26/23
-
73
Pyrrolo[1,2-b]pyridazine derivatives
Gilead Sciences, Inc.
03/26/23
-
69
Bicyclic heterocycles as FGFR inhibitors
Incyte Corporation
03/20/23
-
4
Heterocyclic compounds as immunomodulators
Incyte Corporation
03/20/23
-
2
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)
FORMA Therapeutics, Inc.
03/20/23
-
39
5-heteroaryl-1H-pyrazol-3-amine derivative
Sumitomo Pharma Co., Ltd.
03/19/23
-
158
5-membered heteroaryl carboxamide compounds for treatment of HBV
Assembly Biosciences, Inc.
03/19/23
-
145
Amino acid compounds and methods of use
Pliant Therapeutics, Inc.
03/19/23
-
70
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
03/19/23
-
17
Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
Board of Regents, The University of Texas System
03/19/23
-
158
Cannabinoid receptor type 2 (CB2) modulators and uses thereof
Teon Therapeutics, Inc.
03/19/23
-
50
Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists
Trustees of Tufts College
03/19/23
-
487
Compounds and uses thereof
Foghorn Therapeutics Inc.
03/19/23
-
4
Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
AlternOx Scientific Limited
03/19/23
-
62
Fused amino pyridine as HSP90 inhibitors
Guris, Inc.
03/19/23
-
377
Indole compounds and analogues thereof
BioCryst Pharmaceuticals, Inc.
03/19/23
-
373
Isoquinolines as inhibitors of HPK1
Genentech, Inc.
03/19/23
-
17
Morpholinylpyridone compounds
Sprint Bioscience AB
03/19/23
-
175
Proteasome activity enhancing compounds
Proteostasis Therapeutics, Inc.
03/19/23
-
22
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
03/19/23
-
718
Ras inhibitors
Revolution Medicines, Inc.
03/19/23
-
149
Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors
Pfizer Inc.
03/19/23
-
17
2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
03/12/23
-
474
ACLY inhibitors and uses thereof
Nimbus Artemis, Inc.
03/12/23
-
98
Amide compounds as kinase inhibitors, compositions and methods of treatment
Translational Drug Development LLC
03/12/23
-
215
Bruton's tyrosine kinase inhibitors
SUZHOU BAIJIBUGONG PHARMACEUTICAL TECHNOLOGY CO., LTD.
03/12/23
-
656
PD-1/PD-L1 inhibitors
Gilead Sciences, Inc.
03/12/23
-
22
Phosphonate linkers and their use to facilitate cellular retention of compounds
Merck Sharp & Dohme LLC
03/12/23
-
59
Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
THE USA, AS REPRESENTED BY THE SECRETARY, DHHS
03/12/23
-
46
Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
Amgen Inc.
03/06/23
-
21
Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
Jazz Pharmaceuticals Ireland Limited
03/06/23
-
109
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology Limited
03/06/23
-
137
Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
03/06/23
-
23
Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
Gilead Sciences, Inc.
03/06/23
-
581
Transglutaminase 2 (TG2) inhibitors
Sitari Pharma, Inc.
03/06/23
-
80
Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
LegoChem Biosciences, Inc.
03/05/23
-
822
HPK1 antagonists and uses thereof
Nimbus Saturn, Inc.
03/05/23
-
523
Heterocyclic compounds and uses thereof
MILLENNIUM PHARMACEUTICALS, INC.
03/05/23
-
238
Isoquinolin-3-yl carboxamides and preparation and use thereof
BioSplice Therapeutics, Inc.
03/05/23
-
45
Kinase inhibitor compounds and compositions and methods of use
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
03/05/23
-
9
LSD1 inhibitors and medical uses thereof
Constellation Pharmaceuticals, Inc.
03/05/23
-
59
Neprilysin inhibitors
THERAVANCE BIOPHARMA R&D IP, LLC
03/05/23
-
13
Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1
MANGOSUTHU UNIVERSITY OF TECHNOLOGY
03/05/23
-
31
Therapeutic compounds and methods of use thereof
LIGATURE THERAPEUTICS PTE. LTD.
03/05/23
-
5
Amide compound having bet proteolysis-inducing action and medicinal application thereof
MITSUBISHI TANABE PHARMA CORPORATION
02/26/23
-
47
BTK inhibitor compounds
Eli Lilly and Company
02/26/23
-
10
Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
Janssen Pharmaceutica NV
02/26/23
-
230
Compositions and methods for treating CNS disorders
Sage Therapeutics, Inc.
02/26/23
-
6
Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
SARBONNE UNIVERSITE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE; ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS; INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE; UNIVERSITÉ DE MONTPELLIER; ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
02/26/23
-
65
Compounds for the treatment of kinase-dependent disorders
Exelixis, Inc.
02/26/23
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
SHY Therapeutics LLC
02/26/23
-
108
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals, Inc.
02/26/23
-
6
IRAK degraders and uses thereof
DANA-FARBER CANCER INSTITUTE, INC.
02/26/23
-
27
Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
UNIVERSISITY OF UTAH RESEARCH FOUNDATION
02/26/23
-
42
Phenothiazine derivatives and uses thereof
CAMP4 THERAPEUTICS CORPORATION
02/26/23
-
126
Pyrazolopyrimidine compounds and uses thereof
Incyte Corporation
02/26/23
-
5
Quinoline compounds as IRAK inhibitors and uses thereof
Merck Patent GmbH
02/26/23
-
17
STK19 inhibitors for treatment of cancer
TRUSTEES OF BOSTON UNIVERSITY; XIAMEN UNIVERSITY
02/26/23
-
46
Sting modulator compounds, and methods of making and using
Takeda Pharmaceutical Company Limited
02/26/23
-
51
Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
02/26/23
-
96
Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
02/26/23
-
71
Substituted piperazines as selective HDAC1,2 inhibitors
REGENACY PHARMACEUTICALS, LLC
02/26/23
-
1
Substituted piperidines as BTK inhibitors
HAISCO PHARMACEUTICALS PTE. LTD.
02/26/23
-
8
Synthesis of peptide borate ester compound and use thereof
JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO., LTD.
02/26/23
-
5
Tetrahydroisoquinoline derivatives, preparation process and use thereof
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
02/26/23
-
94
Therapeutic compounds and methods of use thereof
Agency for Science, Technology and Research (A*STAR)
02/26/23
-
16
Analogs of dextromethorphan with balanced receptor activities
Center for Neurologic Study
02/20/23
-
11
Benzisoxazole derivative
Sumitomo Pharma Co., Ltd.
02/20/23
-
155
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals, LLC
02/20/23
-
15
Dioxoloisoquinolinone derivatives and use thereof
HANMI PHARMACEUTICAL CO., LTD.
02/20/23
-
287
Heterobicyclic amides as inhibitors of CD38
Ribon Therapeutics, Inc.
02/20/23
-
21
Heterocyclic compounds as immunomodulators
Incyte Corporation
02/20/23
-
26
Histone deacetylases (HDACs) inhibitors
AnnJi Pharmaceutical Co., Ltd.
02/20/23
-
115
Histone demethylase inhibitors
CELGENE QUANTICEL RESEARCH, INC
02/20/23
-
100
Isoindolines as HDAC inhibitors
Valo Health, Inc.
02/20/23
-
198
MAP4K1 inhibitors
Blueprint Medicines Corporation
02/20/23
-
39
Methods for treating depressive symptoms
ALKERMES PHARMA IRELAND LIMITED
02/20/23
-
85
Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
H. Lundbeck A/S
02/20/23
-
10
Pyrrolo[1,2-b] pyridazine derivatives
Gilead Sciences, Inc.
02/20/23
-
75
Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
02/20/23
-
54
Bicyclic heterocycles as FGFR inhibitors
Incyte Holdings Corporation; Incyte Corporation
02/17/23
-
228
Compositions and methods for treating CNS disorders
Sage Therapeutics, Inc.
02/17/23
-
59
Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
NURIX THERAPEUTICS, INC.
02/17/23
-
382
Cyclic polypeptides for PCSK9 inhibition
Merck Sharp & Dohme LLC; Ra Pharmaceuticals, Inc.
02/17/23
-
3
Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
GENZYME CORPORATION
02/17/23
-
17
Ligands to cereblon (CRBN)
DANA-FARBER CANCER INSTITUTE, INC.
02/17/23
-
93
Naphthyridinone derivatives and their use in the treatment of arrhythmia
Novartis AG
02/17/23
-
16
Small molecule inhibition of transcription factor SALL4 and uses thereof
DANA-FARBER CANCER INSTITUTE, INC.; THE BRIGHAM AND WOMEN''S HOSPITAL, INC.
02/17/23
-
291
Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
JANSSEN PHARMACEUTICA NV
02/17/23
-
9
Use of known compounds as D-amino acid oxidase inhibitors
National Taiwan University; National Yang Ming Chiao Tung University; National Health Research Institutes
02/17/23
-
431
2-(morpholin-4-yl)-1,7-naphthyridines
Bayer Pharma Aktiengesellschaft
02/16/23
-
30
Alpha-5 beta-1 inhibitors
The Regents of the University of California; Shanghai ChemPartner Co., Ltd.
02/16/23
-
45
Analogs for the treatment of disease
Insilico Medicine IP Limited
02/16/23
-
45
Analogs for the treatment of disease
Insilico Medicine IP Limited
02/16/23
-
63
Compositions and methods for treating infections
Vyera Pharmaceuticals, LLC
02/16/23
-
31
Compounds
INFLAZOME LIMITED
02/16/23
-
9
Imidazo[4,5-C]pyridine derived SSAO inhibitors
PROXIMAGEN, LLC
02/16/23
-
123
Kinase inhibitors
The University of Manchester
02/16/23
-
31
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb Company
02/16/23
-
17
Protacs targeting coronavirus 3CL protease and preparation method and application thereof
SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
02/16/23
-
51
SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics, Inc.; D. E. Shaw Research, LLC
02/16/23
-
61
Use of aminomethylenecyclohexane-1,3-dione compound
WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
02/16/23
-
717
Heterocyclic compound as a protein kinase inhibitor
HK inno.N Corporation
02/13/23
-
14
JAK kinase inhibitor and preparation method and use thereof
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD.
02/13/23
-
31
Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
Prelude Therapeutics, Incorporated
02/13/23
-
7
Alkyne substituted quinazoline compound and methods of use
Newgen Therapeutics, Inc.
02/12/23
-
10
Compounds for treating ILK-mediated diseases
The Cleveland Clinic Foundation
02/12/23
-
1076
Indole and azaindole inhibitors of pad enzymes
Bristol-Myers Squibb Company
02/12/23
-
310
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
02/12/23
-
7
Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
VTV THERAPEUTICS LLC
02/12/23
-
15
Pyrazole compounds as LSD1 inhibitors and applications thereof
MEDSHINE DISCOVERY INC.
02/12/23
-
58
CDPK1 inhibitors, compositions, and methods related thereto
Vyera Pharmaceuticals, LLC; Washington University
02/05/23
-
11
Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
Kronos Bio, Inc.
02/05/23
-
50
Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
NIKANG THERAPEUTICS, INC.
02/05/23
-
8
Inhibitors of DNMT1 as anticancer therapeutic agents
Victoria Link Limited; Albert Einstein College of Medicine
02/05/23
-
15
MTOR inhibitor compounds
GALDERMA RESEARCH & DEVELOPMENT
02/05/23
-
2
Macrocycle and composition comprising thereof
Shenzhen TargetRx, Inc.
02/05/23
-
9
Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof
SHAANXI PANLONG PHARMACEUTICAL CO., LTD.
02/05/23
-
10
Radiolabeled pharmaceuticals and methods of making and using same
YALE UNIVERSITY
02/05/23
-
370
Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
02/05/23
-
59
Compounds useful in HIV therapy
GlaxoSmithKline Intellectual Property Development Limited; The University of North Carolina at Chapel Hill; ViiV Healthcare Company
01/31/23
-
50
Aminocyclobutanes as monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
01/28/23
-
250
Anti-tumor effect potentiator using novel biphenyl compound
Taiho Pharmaceutical Co., Ltd.
01/28/23
-
16
BRK inhibitory compound
ONO PHARMACEUTICAL CO., LTD.
01/28/23
-
102
CRBN ligands and uses thereof
KYMERA THERAPEUTICS, INC.
01/28/23
-
139
Compounds and methods for the enhanced degradation of targeted proteins
Arvinas Operations, Inc.; Yale University
01/28/23
-
1
Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
Shenzhen TargetRx, Inc.
01/28/23
-
107
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Takeda Pharmaceutical Company Limited
01/28/23
-
35
2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy
THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING
01/21/23
-
3
Aryl-piperidine derivatives
Artax Biopharma Inc.
01/21/23
-
76
Azaspirocycles as monoacylglycerol lipase modulators
Janssen Pharmaceutica NV
01/21/23
-
159
Compounds and methods for treating oxalate-related diseases
OxaluRx, Inc.
01/21/23
-
138
Dihydroorotate dehydrogenase inhibitors
TBA
01/21/23
-
19
HDAC8 inhibitors for treating cancer
CITY OF HOPE; TAIPEI MEDICAL UNIVERSITY; ACADEMIA SINICA
01/21/23
-
62
Inhibitors of fibroblast activation protein
PRAXIS BIOTECH LLC
01/21/23
-
81
SSAO inhibitor
TBA
01/21/23
-
3
Tetrahydroquinoline derivatives and a process of preparation thereof
KING ABDULAZIZ UNIVERSITY
01/21/23
-
30
Therapeutic compounds and methods of use thereof
LIGATURE THERAPEUTICS PTE. LTD.
01/21/23
-
196
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck A/S
01/20/23
-
150
ACLY inhibitors and uses thereof
Nimbus Artemis, Inc.
01/20/23
-
45
Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
Janssen Sciences Ireland Unlimited Company
01/20/23
-
120
Benzisoxazole sulfonamide derivatives
Pfizer Inc.; CTXT PTY LTD
01/20/23
-
23
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
01/20/23
-
24
Cyclic peptide immunomodulators
Bristol-Myers Squibb Company
01/20/23
-
54
Indazole compounds and uses thereof
Incyte Corporation
01/20/23
-
320
MTA-cooperative PRMT5 inhibitors
Mirati Therapeutics, Inc.
01/20/23
-
66
N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
Nerviano Medical Sciences S.R.L.
01/20/23
-
7
Peptides for treatment of medical disorders
Humanwell Pharmaceutical US
01/20/23
-
4
Therapeutic methods and combinations
TBA
01/20/23
-
2
Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase
Hanmi Pharm. Co., Ltd.
01/20/23
-
153
Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
Neuropore Therapies, Inc.
01/20/23
-
26
Azaindolylpyridone and diazaindolylpyridone compounds
Sprint Bioscience AB
01/17/23
-
38
Dopamine D2 receptor ligands
The Broad Institute, Inc.; Massachusetts Institute of Technology
01/17/23
-
152
Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
BLUERAY THERAPEUTICS (SHANGHAI) CO., LTD
01/17/23
-
275
Tricyclic heterocycles as BET protein inhibitors
Incyte Corporation; Incyte Holdings Corporation
01/17/23
-
368
Amido spirocyclic amide and sulfonamide derivatives
Valo Health, Inc.; Genentech, Inc.
01/06/23
-
137
Compounds and methods useful in the treatment of a PRMT5-mediated disorder
ARGONAUT THERAPEUTICS LIMITED
01/06/23
-
140
Compounds for inhibiting TNIK and medical uses thereof
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
01/06/23
-
127
Compounds for treatment of PD-L1 diseases
ChemoCentryx, Inc.
01/06/23
-
2
Deuterated compounds as rock inhibitors
Fochon Pharmaceuticals, Ltd.
01/06/23
-
82
Mu opioid receptor modulators
The Regents of the University of California; Friedrich-Alexander-Universität Erlangen-Nürnberg; The Board of Trustees of the Leland Stanford Junior University; The University of North Carolina at Chapel Hill
01/06/23
-
35
N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
Boehringer Ingelheim International GmbH
01/06/23
-
222
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
MIRATI THERAPEUTICS, INC.
01/06/23
-
121
Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
KSQ Therapeutics, Inc.
01/06/23
-
5
Synthesis of (+)-cannabinoids and their therapeutic effects
SYMRISE AG
01/06/23
-
222
2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
HUTCHISON MEDIPHARMA LIMITED
12/30/22
-
66
5-5 fused rings as C5a inhibitors
CHEMOCENTRYX, INC.
12/30/22
-
6
5-aminolevulinate synthase inhibitors and methods of use thereof
University of South Florida
12/30/22
-
486
Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
CHEMOCENTRYX, INC.
12/30/22
-
38
EP4 antagonist
ONO PHARMACEUTICAL CO., LTD.
12/30/22
-
49
Heterocyclic RIP1 kinase inhibitors
Rigel Pharmaceuticals, Inc.
12/30/22
-
71
Inhibitors of Rho associated coiled-coil containing protein kinase
Kadmon Corporation, LLC
12/30/22
-
321
MTA-cooperative PRMT5 inhibitors
Mirati Therapeutics, Inc.
12/30/22
-
70
Macrocyclic chlorine substituted indole derivatives
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.
12/30/22
-
6
Method for treating inflammation
KING FAISAL UNIVERSITY
12/30/22
-
225
OX2R compounds
TBA
12/30/22
-
14
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
The Johns Hopkins University
12/30/22
-
154
Small molecule modulators of the BTB domain of Keap1
MedImmune Limited
12/30/22
-
4
Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
Newave Pharmaceutical Inc.
12/30/22
-
4
Substituted piperidine compounds and their use
Eisai R&D Management Co., Ltd.
12/30/22
-
5
Targeted drug rescue with novel compositions, combinations, and methods thereof
TBA
12/30/22
-
24
Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb Company
12/30/22
-
94
Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
12/30/22
-
35
1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
SOUTHERN MEDICAL UNIVERSITY
12/24/22
-
27
1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO—A.C.R.A.F. S.p.A.
12/24/22
-
52
Acyclic antivirals
JANSSEN PHARMACEUTICA NV
12/24/22
-
14
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
12/24/22
-
111
Imidazopyrazinones as PDE1 inhibitors
H. Lundbeck A/S
12/24/22
-
67
Inhibitors of blood coagulation factor XIII
Zedira GmbH
12/24/22
-
172
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
12/24/22
-
1
Mcl-1 inhibitors and methods of use thereof
AstraZeneca AB
12/24/22
-
37
Pyrazolo[1,5-a]pyrazin-4-yl derivatives
Pfizer Inc.
12/24/22
-
186
Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
BEIGENE, LTD.
12/24/22
-
79
Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
Array BioPharma Inc.
12/24/22
-
95
Tricyclic compounds and their use as phosphodiesterase inhibitors
PFIZER, INC.
12/24/22
-
35
Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
BEIGENE, LTD.
12/23/22
-
11
Compounds for treatment of hypoproliferative disorders
LU LICENSE AB
12/23/22
-
27
Diacylglycerol acyl transferase 2 inhibitor
Pfizer Inc.
12/23/22
-
5
Docosahexaenoic acid endocannabinoid epoxide derivative compositions
The Board of Trustees of the University of Illinois
12/23/22
-
279
Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
Incyte Corporation
12/23/22
-
18
Quinazolinones that inhibit the formation of tau oligomers and their method of use
Oligomerix, Inc.
12/23/22
-
93
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
12/23/22
-
146
SSAO inhibitors and use thereof
Eccogene (Shanghai) Co., Ltd.
12/23/22
-
19
Sphingosine analogs and use thereof against bacterial lung infections
Yeda Research and Development Co. Ltd.; University of Duisburg-Essen
12/23/22
-
51
3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
Nurix Therapeutics, Inc.
12/11/22
-
69
Compound functioning as bromodomain protein inhibitor, and composition
Betta Pharmaceuticals Co., Ltd.
12/11/22
-
48
Compound having ERK kinase inhibitory activity and use thereof
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
12/11/22
-
10
Cyclic di-nucleotide compounds as sting agonists
Merck Sharp & Dohme LLC
12/11/22
-
13
Heterocyclic compounds as immunomodulators
Incyte Corporation
12/11/22
-
94
Heterocyclic inhibitors of PTPN11
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
12/11/22
-
16
Modulators of the NMDA receptor
H. Lundbeck A/S
12/11/22
-
60
Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
12/11/22
-
142
Pharmaceutical compounds
OTSUKA PHARMACEUTICAL CO., LTD.; TAIHO PHARMACEUTICAL CO., LTD.
12/11/22
-
31
Pyridazines
Boehringer Ingelheim International GmbH
12/11/22
-
187
Substituted lactams showing serotonin 5-HT receptor activity
SUMITOMO PHARMA CO., LTD.
12/11/22
-
21
Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
Enanta Pharmaceuticals, Inc.
12/11/22
-
27
Tricyclic compounds
JACOBIO PHARMACEUTICALS CO., LTD.
12/11/22
-
15
2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VANDERBILT UNIVERSITY
12/07/22
-
286
6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors
Novartis AG
12/07/22
-
20
Annulated glycosidase inhibitors
Asceneuron SA
12/07/22
-
30
Antibacterial compounds
INFEX Therapeutics Limited
12/07/22
-
140
Biaryl derivative, preparation method thereof and pharmaceutical application thereof
ABBISKO THERAPEUTICS CO., LTD.
12/07/22
-
72
Broad spectrum antiviral compositions and methods
Evrys Bio, LLC
12/07/22
-
74
Broad spectrum inhibitors of filoviruses
Microbiotix, Inc.; Albert Einstein College of Medicine; The Government of the United States as Represented by the Secretary of the Army
12/07/22
-
3
Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors
Suven Life Sciences Limited
12/07/22
-
3
Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
PHARMAKEA, INC.
12/07/22
-
108
Heterocyclic compounds for the inhibition of PASK
BioEnergenix LLC
12/07/22
-
71
Imidazopyridazine and imidazopyridine compounds and uses thereof
Incyte Corporation
12/07/22
-
48
Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
Chia Tai Tianqing Pharmaceutical Group Co., Inc.
12/07/22
-
227
Modulators of methyl modifying enzymes, compositions and uses thereof
Constellation Pharmaceuticals, Inc.
12/07/22
-
160
N/O-linked Degrons and Degronimers for protein degradation
C4 Therapeutics, Inc.
12/07/22
-
67
Pyrazine carbamates and their use as GluN2B receptor modulators
JANSSEN PHARMACEUTICA NV
12/07/22
-
5
Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors
VIMALAN BIOSCIENCES, INC.
12/07/22
-
229
TEAD inhibitors and uses thereof
IKENA ONCOLOGY, INC.
12/07/22
-
36
Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
NIKANG THERAPEUTICS, INC.
12/07/22
-
15
3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
MINDSET PHARMA INC.
12/04/22
-
215
Cyclic di-nucleotide compounds as sting agonists
Merck Sharp & Dohme LLC
12/04/22
-
25
JAK inhibitors containing a 4-membered heterocyclic amide
THERAVANCE BIOPHARMA R&D IP, LLC
12/04/22
-
452
KRas G12D inhibitors
MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA INC.
12/04/22
-
143
Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
BEIJING TIDE PHARMACEUTICAL CO., LTD.
12/04/22
-
576
Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
12/04/22
-
16
Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
ELI LILLY AND COMPANY
12/04/22
-
72
Substituted eneoxindoles and uses thereof
Gilead Sciences, Inc.
12/04/22
-
44
Substituted propanamides as inhibitors of nucleases
MASARYKOVA UNIVERZITA
12/04/22
-
1
Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors
SHENZHEN TARGETRX, INC.
12/04/22
-
29
Tricyclic compounds useful to treat orthomyxovirus infections
Novartis AG
12/04/22
-
4
(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
Histogen, Inc.
11/20/22
-
66
Galactoside inhibitor of galectins
GALECTO BIOTECH AB
11/20/22
-
49
Macrocyclic chlorine substituted indole derivatives
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.
11/20/22
-
225
Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
Cancer Research Technology Limited
11/20/22
-
12
Tricyclic amine compounds as CDK2 inhibitors
Incyte Corporation
11/20/22
-
360
Aminoimidazopyridazines as kinase inhibitors
Bristol-Myers Squibb Company
11/19/22
-
116
Anti-inflammatory compound, and preparation and use thereof
E-Nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.
11/19/22
-
25
Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD
11/19/22
-
83
Compound exhibiting enteropeptidase inhibitory activity
LG CHEM, LTD.
11/19/22
-
90
Compounds, salts thereof and methods for treatment of diseases
ACADIA PHARMACEUTICALS INC.
11/19/22
-
64
Cyclic compound having dopamine D3 receptor antagonistic effect
SHIONOGI & CO., LTD.
11/19/22
-
10
Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof
Korea Research Institute of Chemical Technology; Industry-Academic Cooperation Foundation, Yonsei University
11/19/22
-
32
Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
Recordati Industria Chimica e Farmacentica S.p.A.
11/19/22
-
33
Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof
HINOVA PHARMACEUTICALS INC.
11/19/22
-
95
Inhibitors of cyclin-dependent kinases
TBA
11/19/22
-
118
Pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
11/19/22
-
46
Pyrimidine JAK inhibitors for the treatment of skin diseases
THERAVANCE BIOPHARMA R&D IP, LLC
11/19/22
-
98
Pyrimidine TBK/IKKe inhibitor compounds and uses thereof
Merck Patent GmbH
11/19/22
-
7
Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD.
11/19/22
-
5
Selective A2A receptor antagonist
INXMED (NANJING) CO., LTD.
11/19/22
-
94
Spiroheptanyl hydantoins as rock inhibitors
Bristol-Myers Squibb Company
11/19/22
-
6
Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity
The Board of Trustees of the Leland Stanford Junior University
11/19/22
-
79
Substituted macrocyclic indole derivatives
TBA
11/19/22
-
30
Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
TBA
11/19/22
-
353
Tetrahydroquinoline derivatives as P2X7 receptor antagonists
RaQualia Pharma Inc.; Asahi Kasei Pharma Corporation
11/19/22
-
22
Triazolo-azepine derivatives
Hoffmann-La Roche Inc.
11/19/22
-
32
Tricyclic amine compounds as CDK2 inhibitors
Incyte Corporation
11/19/22
-
10
p38α mitogen-activated protein kinase inhibitors
GEN1E LIFESCIENCES INC.
11/19/22
-
12
ASK1 inhibitor compounds and uses thereof
SEAL ROCK THERAPEUTICS, INC.
11/13/22
-
56
ATR inhibitor and application thereof
Wuxi Biocity Biopharmaceutics Co., Ltd.
11/13/22
-
129
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System; ChemPartner Corporation
11/13/22
-
359
Heterocyclylamines as PI3K inhibitors
Incyte Corporation; Incyte Holdings Corporation
11/13/22
-
164
LSD1 inhibitor and preparation method and application thereof
MEDSHINE DISCOVERY INC.
11/13/22
-
70
PDE9 inhibitor and use thereof
Nanjing TransThera Biosciences Co. Ltd.
11/13/22
-
17
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech, Inc.
11/13/22
-
166
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
11/13/22
-
70
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
Aerie Pharmaceuticals, Inc.
11/07/22
-
69
Bromodomain inhibitor compound and use thereof
Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Suzhou Suplead Life Sciences Co., Ltd.
11/07/22
-
124
Composition and methods for inhibiting mammalian sterile 20-like kinase 1
THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN
11/07/22
-
8
Cycloalkyl-diamines for the treatment of inflammation
MediSynergics, LLC
11/07/22
-
291
Dihydrooxadiazinones
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.
11/07/22
-
40
IRAK4 inhibiting agents
BIOGEN MA INC.
11/07/22
-
84
Imidazo-pyridine compounds as PAD inhibitors
JUBILANT EPIPAD LLC
11/07/22
-
465
Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
Incyte Corporation
11/07/22
-
312
Immunomodulator compounds
ChemoCentryx, Inc.
11/07/22
-
332
Indazoles and azaindazoles as LRRK2 inhibitors
ESCAPE Bio, Inc.
11/07/22
-
543
Inhibitors of KEAP1-Nrf2 protein-protein interaction
Janssen Pharmaceutica NV
11/07/22
-
22
JAK inhibitor and use thereof
ZHUHAI UNITED LABORATORIES CO., LTD.
11/07/22
-
13
Kinase inhibitors
Insilico Medicine IP Limited
11/07/22
-
24
Prolyl hydroxylase inhibitors and methods of use
Akebia Therapeutics, Inc.
11/07/22
-
4
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma Inc.
11/07/22
-
84
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
The Johns Hopkins University; Institute of Organic Chemistry & Biochemistry
11/07/22
-
228
Substituted pyrrolopyridine-derivatives
Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft; Deutsches Krebsforschungszentrum
11/07/22
-
1
Substituted quinolines useful as kinase inhibitors
Teligene Ltd.
11/07/22
-
22
4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
NERVIANO MEDICAL SCIENCES S.R.L.
11/06/22
-
208
Amide substituted indole compounds useful as TLR inhibitors
Bristol-Myers Squibb Company
11/06/22
-
29
Arginase inhibitors and methods of use thereof
AstraZeneca AB
11/06/22
-
452
Aryl and heteroaryl substituted indole compounds
Bristol-Myers Squibb Company
11/06/22
-
589
Bcl-2 inhibitors
BEIGENE, LTD.
11/06/22
-
150
Bicyclic compounds
VIVACE THERAPEUTICS, INC.
11/06/22
-
18
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
XWPHARMA LTD.
11/06/22
-
26
DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof
Yunnan University; Kunming Institute of Zoology, Chinese Academy of Sciences
11/06/22
-
145
Dosage forms and regimens for amino acid compounds
Pliant Therapeutics, Inc.
11/06/22
-
67
Heterocyclic compounds as anti-viral agents
ENANTA PHARMACEUTICALS, INC.
11/06/22
-
16
Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
NIKANG THERAPEUTICS, INC.
11/06/22
-
316
Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
NOVARTIS AG
11/06/22
-
39
Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors
TRANSTHERA SCIENCES (NANJING), INC.
11/06/22
-
67
Substituted pyrrolopyridines as JAK inhibitors
TBA
11/06/22
-
30
Treatment of tachycardia
OSLO UNIVERSITY HOSPITAL HF
11/06/22
-
53
AMPK activators
KALLYOPE, INC.
11/05/22
-
22
Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
Gwangju Institute of Science and Technolgy; Korea Advanced Institute of Science and Technology; KyungPook National University Industry-Academic Cooperation Foundation; Curacle Co., LTD.
11/05/22
-
149
Compounds and uses thereof
Foghorn Therapeutics Inc.
10/30/22
-
78
Compounds for the treatment of BRAF-associated diseases and disorders
Array BioPharma Inc.
10/30/22
-
5
Compounds useful as immunomodulators
Bristol-Myers Squibb Company
10/30/22
-
97
Formulations of Tie-2 activators and methods of use thereof
EYEPOINT PHARMACEUTICALS, INC.
10/30/22
-
55
Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
Suzhou Longbiotech Pharmaceuticals Co., Ltd.
10/30/22
-
66
Heterocyclic compounds as immunomodulators
Incyte Corporation
10/30/22
-
136
Heterocyclic compounds as modulators of mGluR7
Pragma Therapeutics
10/30/22
-
212
Inhibitors of protein kinases
Alexion Pharmaceuticals, Inc.
10/30/22
-
19
Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
Auckland UniServices Limited
10/30/22
-
103
Oxoacridinyl acetic acid derivatives and methods of use
STINGTHERA, INC.
10/30/22
-
379
P300/CBP hat inhibitors
Constellation Pharmaceuticals, Inc.
10/30/22
-
1022
Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
Nimbus Lakshmi, Inc.
10/30/22
-
37
Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
MISSION THERAPEUTICS LIMITED
10/30/22
-
6
Acetamide thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute, Inc.
10/28/22
-
58
Antibacterial compounds
FORGE THERAPEUTICS, INC.
10/28/22
-
121
Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals, Inc.
10/28/22
-
80
CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
AMGEN INC.
10/28/22
-
3
Derivatives of an FGFR inhibitor
Incyte Corporation
10/28/22
-
36
Dioxinoquinoline compounds, preparation method and uses thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
10/28/22
-
114
Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
Development Center for Biotechnology
10/28/22
-
27
Heterocyclic compounds as immunomodulators
Incyte Corporation
10/28/22
-
85
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
10/28/22
-
26
JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
Incyte Corporation
10/28/22
-
118
Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
Washington University
10/28/22
-
16
Pyrazolopyridine compounds and uses thereof
Incyte Corporation
10/28/22
-
208
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
10/28/22
-
13
Substituted piperidines as kinase inhibitors
Daewoong Pharmaceutical Co., Ltd.
10/28/22
-
13
Treatment of upper aerodigestive tract disorders and cough
TBA
10/28/22
-
79
Tropomyosin-related kinase (TRK) inhibitors
Genzyme Corporation
10/28/22
-
22
1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
NOVARTIS AG
10/23/22
-
153
Alcoxyamino derivatives for treating pain and pain related conditions
ESTEVE PHARMACEUTICALS, S.A.
10/23/22
-
1
Biochemical binding of RET9 and VEGFR2 inhibitors
Kala Pharmaceuticals, Inc.
10/23/22
-
23
Cyclic dinucleotide compound and uses thereof
SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD.; JIANGXI JEMINCARE GROUP CO., LTD.
10/23/22
-
64
Dihydroquinolinones for medical treatment
C4 Therapeutics, Inc.
10/23/22
-
307
Heteroaryl inhibitors of PDE4
Tetra Discovery Partners, LLC
10/23/22
-
138
Heterocyclic compounds as LSD1 inhibitors
Incyte Corporation
10/23/22
-
11
Isoquinoline derivatives and use thereof
Purdue Pharma L.P.
10/23/22
-
62
Macrocyclic indole derivatives
The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
10/23/22
-
40
Pyrido[3,2-d]pyrimidine compounds as immunomodulators
Incyte Corporation
10/23/22
-
81
Pyrimidinones as PI3K inhibitors
Incyte Holdings Corporation; Incyte Corportion
10/23/22
-
41
Small molecule activators of Parkin enzyme function
Mayo Foundation for Medical Education and Research
10/23/22
-
8
[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
ELI LILLY AND COMPANY
10/23/22
-
23
1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
10/17/22
-
34
Amine compound for inhibiting SSAO/VAP-1 and use thereof
SUNSHINE LAKE PHARMA CO., LTD.
10/17/22
-
15
Amino acid compounds with unbranched linkers and methods of use
Pliant Therapeutics, Inc.
10/17/22
-
21
Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
10/17/22
-
479
Benzodiazepine derivatives as RSV inhibitors
Enanta Pharmaceuticals, Inc.
10/17/22
-
218
CDK2/4/6 inhibitors
Pfizer Inc.
10/17/22
-
45
Substituted heterocyclic derivatives as PI3K inhibitors
Incyte Corporation
10/17/22
-
601
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
10/17/22
-
2
Tricyclic compounds as Cyp1 inhibitors
The General Hospital Corporation
10/17/22
-
267
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics Limited
10/16/22
-
66
Arginase inhibitors as therapeutics
Mars, Incorporated
10/16/22
-
104
Compounds and methods for treating oxalate-related diseases
OxaluRx, Inc.
10/16/22
-
34
Compounds for targeting mutant huntingtin protein and uses thereof
CHDI Foundation, Inc.
10/16/22
-
159
Inhibitors of cyclin-dependent kinases
KINNATE BIOPHARMA INC.
10/16/22
-
7
Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
Beijing Innocare Pharma Tech Co., Ltd.
10/16/22
-
215
Piperazine derivatives as MAGL inhibitors
Hoffmann-La Roche Inc.
10/16/22
-
47
Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
Incyte Corporation
10/16/22
-
314
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
BEIJING TIDE PHARMACEUTICAL CO., LTD.
10/16/22
-
38
Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
10/09/22
-
1
Diphenylaminopyrimidine compound for inhibiting kinase activity
Shenzhen TargetRx, Inc.
10/09/22
-
20
Heterocyclic compound as CSF-1R inhibitor and use thereof
MEDSHINE DISCOVERY INC.
10/09/22
-
45
Heterocyclic compounds useful as aurora a selective inhibitors
Jacobio Pharmaceuticals Co., Ltd.
10/09/22
-
120
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
10/09/22
-
7
Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
UNION therapeutics A/S
10/09/22
-
19
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
Incyte Corporation
10/09/22
-
209
2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
Merck Sharp & Dohme LLC
10/06/22
-
132
CD73 inhibitors
ORIC PHARMACEUTICALS, INC.
10/06/22
-
106
Galactoside inhibitor of galectins
Galecto Biotech AB
10/06/22
-
164
Heterocyclic prolinamide derivatives
ORION OPHTHALMOLOGY LLC
10/06/22
-
41
Acetyl-CoA carboxylase modulators
Monsanto Technology LLC
10/05/22
-
20
Inhibiting mutant IDH-1
FORMA Therapeutics, Inc.
10/05/22
-
56
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
10/05/22
-
19
Inhibitors of histone deacetylase
The Broad Institute, Inc.; The General Hospital Corporation
10/05/22
-
34
Purine derivatives and the use thereof as medicament
Boehringer Ingelheim International GmbH
10/05/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
10/05/22
-
177
Serine/threonine kinase inhibitors
Genentech, Inc.
10/05/22
-
32
3-arylindazoles as selective MEK4 inhibitors
NORTHWESTERN UNIVERSITY
09/25/22
-
10
Antimalarial compounds, process for preparation and their use for drug resistant malaria
Council of Scientific and Industrial Research; International Centre for Genetic Engineering and Biotechnology (ICGEB)
09/25/22
-
229
Compounds
TMEM16A LIMITED
09/25/22
-
23
Compounds and methods for inhibiting CPY26 enzymes
Queen''s University at Kingston
09/25/22
-
54
Compounds that inhibit Mcl-1 protein
AMGEN INC.
09/25/22
-
549
Compounds useful as inhibitors of ATR kinase
VERTEX PHARMACEUTICALS INCORPORATED
09/25/22
-
92
Cyano-substituted heterocycles with activity as inhibitors of USP30
MISSION THERAPEUTICS LIMITED
09/25/22
-
79
FGFR inhibitor and application thereof
Betta Pharmaceuticals Co., Ltd.
09/25/22
-
598
GLS1 inhibitors for treating disease
Board of Regents, The University of Texas System
09/25/22
-
21
Heteroaryl plasma kallikrein inhibitors
Takeda Pharmaceutical Company Limited
09/25/22
-
60
Heterocyclic inhibitors of tyrosine kinase
Board of Regents, The University of Texas System
09/25/22
-
124
Imidazolidin-2-one compounds as PRMT5 modulators
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
09/25/22
-
27
Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
Eli Lilly and Company
09/25/22
-
365
Melt-extruded solid dispersions containing an apoptosis-inducing agent
AbbVie Inc.; AbbVie Deutschland GMBH & Co KG
09/25/22
-
10
Optically active azabicyclo ring derivative
Sumitomo Dainippon Pharma Co., Ltd.
09/25/22
-
17
P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof
SHANGHAI ZHIMENG BIOPHARMA INC.
09/25/22
-
47
Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer
PELEMED CO., LTD.
09/25/22
-
5
Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
Imara Inc.
09/25/22
-
447
Pyridine compound substituted with azole
TAISHO PHARMACEUTICAL CO., LTD.
09/25/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals Inc.
09/25/22
-
14
Substituted benzimidazoles, their preparation and their use as pharmaceuticals
EPIGENETIX, INC.
09/25/22
-
528
Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
BioCryst Pharmaceuticals, Inc.
09/25/22
-
185
Substituted cyclohexyl compounds as NOP inhibiiors
Dart NeuroScience, LLC
09/25/22
-
73
Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
Union therapeutics A/S
09/25/22
-
62
Substituted pyrazoles as LRRK2 inhibitors
OSCOTEC INC.
09/25/22
-
7
Therapeutic compounds and uses thereof
Kala Pharmaceuticals, Inc.
09/25/22
-
31
CRBN ligands and uses thereof
KYMERA THERAPEUTICS, INC.
09/19/22
-
9
Compounds and methods for inhibiting CYP26 enzymes
Queen''s University at Kingston
09/19/22
-
29
Functionalized peptides as antiviral agents
Enanta Pharmaceuticals, Inc.
09/19/22
-
102
Lysyl oxidase-like 2 inhibitors and uses thereof
PharmAkea, Inc.
09/19/22
-
12
Prodrugs of modulators of the NMDA receptor
H. Lundbeck A/S
09/19/22
-
56
Compounds useful as RET inhibitors
Cancer Research Technology Limited
09/11/22
-
122
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
09/11/22
-
305
TGF-beta inhibitors
Rigel Pharmaceuticals, hic.; Bristol-Myers Squibb Company
09/11/22
-
198
1-cyano-pyrrolidine derivatives as DUB inhibitors
MISSION THERAPEUTICS LIMITED
09/10/22
-
261
2,4-disubstituted pyrimidines useful as kinase inhibitors
Celgene CAR LLC
09/10/22
-
163
Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
Jubilant Epicore LLC
09/10/22
-
347
HIV protease inhibitors
Gilead Sciences, Inc.
09/10/22
-
324
Inhibitors of plasma kallikrein and uses thereof
Takeda Pharmaceutical Company Limited
09/10/22
-
89
Nitrile-containing antiviral compounds
Pfizer Inc.
09/10/22
-
210
Phenoxymethyl derivatives
Hoffmann-La Roche Inc.
09/10/22
-
281
Pyridine and pyridimine compounds as PI3K-gamma inhibitors
Incyte Corporation
09/10/22
-
33
Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
Xiamen University
09/10/22
-
16
Substituted pyrimidines as CDK4/6 inhibitors
Beijing Xuanyi PharmaSciences Co., Ltd.
09/10/22
-
241
2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
TBA
09/05/22
-
33
Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
PHARMAKEA, INC.
09/05/22
-
152
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
09/05/22
-
28
Autotaxin inhibitor compounds
Sabre Therapeutics LLC
09/05/22
-
42
Benzamide compounds
Recurium IP Holding, LLC
09/05/22
-
69
Benzopyrazole compound used as RHO kinase inhibitor
MEDSHINE DISCOVERY INC.
09/05/22
-
280
Inhibitors of fibroblast growth factor receptor kinases
KINNATE BIOPHARMA INC.
09/05/22
-
9
KRAS mutant protein inhibitors
JACOBIO PHARMACEUTICALS CO., LTD.
09/05/22
-
137
Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
SHIONOGI & CO., LTD.
09/05/22
-
43
PGDH inhibitors and methods of making and using
MYOFORTE THERAPEUTICS, INC.
09/05/22
-
128
Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
Janssen Pharmaceutica NV
09/05/22
-
20
Quaternary lactam compound and pharmaceutical use thereof
SHANGHAI MEIYUE BIOTECH DEVELOPMENT CO., LTD.
09/05/22
-
64
Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
Guangzhou Innocare Pharma Tech Co., Ltd.
09/05/22
-
2
Substituted pyrazolopyrimidines useful as kinases inhibitors
Teligene Ltd.
09/05/22
-
31
4H-pyrrolo[3,2-c]pyridin-4-one derivatives
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; Dana-Farber Cancer Institute, Inc.; The Broad Institute, Inc.
08/29/22
-
75
Aliphatic acid amide derivative
SUMITOMO DAINIPPON PHARMA CO., LTD.
08/29/22
-
35
Glycoside derivatives and uses thereof
Novartis AG
08/29/22
-
52
Imidazole and triazole containing bicyclic compounds as JAK inhibitors
Theravance Biopharma R&D IP, LLC
08/29/22
-
55
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
08/29/22
-
33
Substituted piperidines as kinase inhibitors
Daewoong Pharmaceutical Co., Ltd.
08/29/22
-
207
Compounds and methods for kinase modulation, and indications therefor
Plexxikon Inc.
08/28/22
-
34
Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
08/28/22
-
466
Heteroaryl Rheb inhibitors and uses thereof
NAVITOR PHARMACEUTICALS, INC.
08/28/22
-
266
Heterocyclic compounds as immunomodulators
Incyte Corporation
08/28/22
-
34
Identification of stabilizers of multimeric proteins
Leland Stanford Junior University
08/28/22
-
28
Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
08/28/22
-
11
hTRPV1 chemical agents
University of Pittsburgh—Of the Commonwealth System of Higher Education
08/28/22
-
12
CD73 inhibitors and therapeutic uses thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/21/22
-
22
Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
08/21/22
-
33
Inhibitors of lysine gingipain
CORTEXYME, INC.
08/21/22
-
42
MAGL inhibitors
H. LUNDBECK A/S
08/21/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
08/21/22
-
30
Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
NUVATION BIO INC.
08/21/22
-
19
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
08/15/22
-
203
CD73 inhibitors
ORIC PHARMACEUTICALS, INC.
08/15/22
-
26
CaMKII inhibitors and uses thereof
The Johns Hopkins University
08/15/22
-
32
Chemical compounds
ASTRAZENECA AB
08/15/22
-
68
Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
The Governors of the University of Alberta
08/15/22
-
18
Optically active crosslinked cyclic secondary amine derivative
Sumitomo Dainippon Pharma Co., Ltd.
08/15/22
-
134
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals, Inc.
08/15/22
-
22
Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
VALO HEALTH, INC.
08/15/22
-
26
Combination therapy for treatment of hematological diseases
Incyte Corporation
08/14/22
-
67
Ketone inhibitors of lysine gingipain
CORTEXYME, INC.
08/14/22
-
42
Benzamide compounds
Recurium IP Holdings, LLC
08/07/22
-
147
Cyanopyrrolidines as dub inhibitors for the treatment of cancer
MISSION THERAPEUTICS LIMITED
08/07/22
-
415
Inhibitors of Bruton's tyrosine kinase and methods of their use
Janssen Pharmaceutica NV
08/07/22
-
22
Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
Temple University—Of The Commonwealth System of Higher Education; Praeventix, LLC
08/07/22
-
121
Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
08/07/22
-
708
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Propellon Therapeutics Inc.
08/07/22
-
18
Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer
JUBILANT BIOSYS LIMITED
08/07/22
-
173
9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
Merck Sharp & Dohme Corp.
08/06/22
-
61
9H-pyrrolo-dipyridine derivatives
TBA
08/06/22
-
410
Azabenzimidazoles and their use as AMPA receptor modulators
Janssen Pharmaceutica NV
08/06/22
-
17
Ghrelin O-acyltransferase inhibitors
Glaxosmithkline Intellectual Property Development Limited
08/06/22
-
46
Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/06/22
-
113
Hsp90 inhibitors and uses thereof
TRUSTEES OF BOSTON UNIVERSITY; The Governing Council of the University of Toronto
08/06/22
-
91
Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors
Pfizer Inc.
08/06/22
-
20
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
FORMA Therapeutics, Inc.
08/06/22
-
177
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
08/06/22
-
375
Macrocyclic flu endonuclease inhibitors
Janssen BioPharma, Inc.
08/06/22
-
19
Morpholine derivative
Hoffmann-La Roche Inc.
08/06/22
-
83
Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
Merck Sharp & Dohme Corp.
08/06/22
-
6
Protease inhibitors
Medivir AB
08/06/22
-
182
Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
THE ROCKEFELLER UNIVERSITY
08/06/22
-
63
Pyrazole compound
SUMITOMO DAINIPPON PHARMA CO., LTD.
08/06/22
-
193
Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
08/06/22
-
37
Thienodiazepine derivatives and application thereof
CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.
08/06/22
-
54
Treatment of GVHD
KADMON CORPORATION, LLC; REGENTS OF THE UNIVERSITY OF MINNESOTA
08/06/22
-
78
4,6 dihydropyrrolo [3,4-C] pyrazole-5 (1H)-carbonitrile derivates for treating cancer
MISSION THERAPEUTICS LIMITED
08/01/22
-
25
Cyano thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute, Inc.
08/01/22
-
23
Inhibitors of KRAS G12C and methods of using the same
AMGEN INC.
08/01/22
-
47
Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
Venenum Biodesign, LLC
08/01/22
-
85
3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
Incyte Corporation
07/31/22
-
22
Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
Oligomerix, Inc.
07/31/22
-
29
Heterocyclic compounds as adenosine antagonists
Nuvation Bio Inc.
07/31/22
-
176
Phenylacetamides as inhibitors of rock
Bristol-Myers Squibb Company
07/31/22
-
475
Piperidine CXCR7 receptor modulators
IDORSIA PHARMACEUTICALS LTD.
07/31/22
-
52
Substituted quinazolines for inhibiting kinase activity
NEUPHARMA, INC.
07/31/22
-
213
Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors
Boehringer Ingelheim International GmbH
07/31/22
-
26
Treatment of hidradenitis suppurativa using JAK inhibitors
Incyte Corporation
07/31/22
-
156
2-arylsulfonamido-N-arylacetamide derivatized STAT3 inhibitors
University of Hawaii
07/28/22
-
83
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
07/24/22
-
47
Benzimidazole and indole compounds and uses thereof
Incyte Corporation
07/24/22
-
10
Chemical compounds
GlaxoSmithKline Intellectual Property (No. 2) Limited
07/24/22
-
66
Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
Bristol-Myers Squibb Company
07/24/22
-
108
Heterocyclic compounds and uses thereof
Nuvation Bio Inc.
07/24/22
-
27
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D IP, LLC
07/24/22
-
24
Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
UNION therapeutics A/S
07/24/22
-
1
Combination therapy involving diaryl macrocyclic compounds
TURNING POINT THERAPEUTICS, INC.
07/21/22
-
3
Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same
Medicare Pharmaceuticals Inc.; MEDICARE LC.
07/21/22
-
37
Diarylhydantoin compounds and methods of use thereof
Nuvation Bio Inc.
07/21/22
-
237
Heterocyclic inhibitors of MCT4
Vettore, LLC
07/21/22
-
18
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
Hanmi Pharm. Co., Ltd.
07/21/22
-
184
Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
REATA PHARMACEUTICALS, INC.
07/21/22
-
171
RAD51 inhibitors
Cyteir Therapeutics, Inc.
07/21/22
-
16
Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
UNION THERAPEUTICS A/S
07/21/22
-
256
Substituted piperidine compound and use thereof
TAKEDA PHARMACEUTICAL COMPANY LIMITED
07/21/22
-
781
Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
FORMA Therapeutics, Inc.
07/21/22
-
82
Tricyclic CRBN ligands and uses thereof
KYMERA THERAPEUTICS, INC.
07/21/22
-
32
Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
Daegu-Gyeongbuk Medical Innovation Foundation; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; Kyungpook National University Industry-Academic Cooperation Foundation
07/16/22
-
1775
EIF4E-inhibiting compounds and methods
eFFECTOR Therapeutics, Inc.
07/16/22
-
33
Macrocyclic fluorine substituted indole derivatives
The Broad Institute, Inc.; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
07/16/22
-
390
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
Incyte Corporation; Incyte Holdings Cororation
07/16/22
-
6
Pyrrolidine compounds
Eli Lilly and Company
07/16/22
-
369
Substituted piperazines as KRAS G12C inhibitors
AMGEN INC.
07/16/22
-
9
AMPK activators
KALLYOPE, INC.
07/10/22
-
51
Aromatic derivative, preparation method for same, and medical applications thereof
BIOARDIS LLC
07/10/22
-
19
Compound as selective JAK inhibitor, and salt and therapeutic use thereof
Suzhou Longbiotech Pharmaceuticals Co., Ltd.
07/10/22
-
435
Compounds and compositions for the inhibition of NAMPT
Valo Health, Inc.; Genentech, Inc.
07/10/22
-
9
Enantiomers of substituted thiazoles as antiviral compounds
Innovative Molecules GmbG
07/10/22
-
229
Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
APTOSE BIOSCIENCES INC.
07/10/22
-
41
Inhibitors of RET
BLUEPRINT MEDICINES CORPORATION
07/10/22
-
61
Macrocyclic compounds that inhibit MCL-1 protein
AMGEN INC.
07/10/22
-
63
Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
TBA
07/10/22
-
171
Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
AMGEN INC.
07/05/22
-
291
Colony stimulating factor-1 receptor (CSF-1R) inhibitors
GENZYME CORPORATION
07/05/22
-
28
Tricyclic compounds for use in treatment of proliferative disorders
ARGONAUT THERAPEUTICS LIMITED
07/05/22
-
32
Cyclopentane compounds
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
07/04/22
-
55
MAPK inhibitors
EverBrilliant Pharma Pty Ltd
07/04/22
-
16
Modulators of methyl modifying enzymes, compositions and uses thereof
Constellation Pharmaceuticals, Inc.
07/04/22
-
375
P300/CBP HAT inhibitors
Constellation Pharmaceuticals, Inc.
07/04/22
-
34
Pharmaceutical composition for ANO1 antagonist with anticancer activity
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY
07/04/22
-
1
Aminopyrimidine compound and composition comprising same and use thereof
Shenzhen TargetRx, Inc.
06/26/22
-
14
Benzamide derivatives as PPAR-gamma modulators
Medibiofarma, S.L.
06/26/22
-
48
Carbocyclic prolinamide derivatives
ORION OPHTHALMOLOGY LLC
06/26/22
-
19
Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
SHANGHAI RINGENE BIOPHARMA CO., LTD.
06/26/22
-
1
Indazole compound for use in inhibiting kinase activity, composition and application thereof
Shenzhen TargetRx, Inc.
06/26/22
-
224
Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
IDORSIA PHARMACEUTICALS LTD
06/26/22
-
17
Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
KING ABDULAZIZ UNIVERSITY
06/26/22
-
105
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Array BioPharma Inc.
06/26/22
-
331
Small molecule inhibitors of galectin-3
Bristol-Myers Squibb Company
06/26/22
-
3
Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
SHIONOGI & CO., LTD.; VIIV HEALTHCARE COMPANY
06/26/22
-
516
Triaryl compounds for treatment of PD-L1 diseases
ChemoCentryx, Inc.
06/26/22
-
14
Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
Jubilant Biosys Limited
06/26/22
-
73
19-NOR neuroactive steroids and methods of use thereof
Sage Therapeutics, Inc.
06/24/22
-
15
Aromatic compound, pharmaceutical composition and use thereof
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
06/24/22
-
587
Biaryl derivative as GPR120 agonist
LG CHEM. LTD.
06/24/22
-
53
Bicyclic heterocyclic derivatives
Merck Patent GmbH
06/24/22
-
48
Dihydropyrimidine compounds and uses thereof in medicine
SUNSHINE LAKE PHARMA CO., LTD.
06/24/22
-
205
Imidazotriaines and imidazopyrimidines as kinase inhibitors
INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
06/24/22
-
51
Sulfoximine glycosidase inhibitors
Asceneuron SA
06/24/22
-
126
TRPV4 antagonists
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
06/24/22
-
41
[1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors
Boehringer Ingelheim International GmbH
06/24/22
-
9
1,8-naphthyridinone compounds and uses thereof
NUVATION BIO INC.
06/19/22
-
637
Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor
Corvus Pharmaceuticals, Inc.
06/19/22
-
11
Fused imidazo-piperidine JAK inhibitors
THERAVANCE BIOPHARMA R&D IP, LLC
06/19/22
-
72
Pyrazole derivative compound and use thereof
HANMI PHARM. CO., LTD.
06/19/22
-
371
Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
Pfizer Inc.
06/19/22
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics Incorporated
06/19/22
-
45
Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
06/19/22
-
71
3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
Ludwig Institute for Cancer Research Ltd
06/17/22
-
22
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
TES PHARMA S.R.L.
06/17/22
-
43
N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
Korea Research Institute of Chemical Technology
06/17/22
-
409
Substituted bicyclic compounds as farnesoid X receptor modulators
Bristol-Myers Squibb Company
06/17/22
-
3
Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist
Suven Life Sciences Limited
06/17/22
-
508
Bicyclic fused pyridine compounds as inhibitors of TAM kinases
ARRAY BIOPHARMA INC
06/13/22
-
114
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
University of Washington through its Center for Commercialization
06/13/22
-
69
Compounds and methods for inhibiting JAK
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
06/13/22
-
116
Cyclopropylamines as LSD1 inhibitors
Incyte Corporation
06/13/22
-
11
FXR (NR1H4) modulating compounds
Gilead Sciences, Inc.
06/13/22
-
63
Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
SHANGHAI DE NOVO PHARMATECH CO., LTD.
06/13/22
-
4
Metalloenzyme inhibitor compounds
Mycovia Pharmaceuticals, Inc.
06/13/22
-
288
PCSK9 inhibitors and methods of use thereof
AstraZeneca AB
06/13/22
-
157
Phenyl indole allosteric inhibitors of P97 ATPase
University of Pittsburgh—Of the Commonwealth System of Higher Education; National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services; The Regents of the University of California
06/13/22
-
3
Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
ONCOBIX CO., LTD.
06/13/22
-
34
Quinazoline and indole compounds to treat medical disorders
Achillion Pharmaceuticals, Inc.
06/13/22
-
172
Therapeutic compounds and uses thereof
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
06/13/22
-
52
Tricyclic inhibitors of poly(ADP-ribose)polymerase
Rakovina Therapeutics Inc.
06/13/22
-
510
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
06/12/22
-
86
(4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
Genentech, Inc.
06/10/22
-
12
2-phenyl-3,4-dihydropyrrolo[2,1-Ff] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
TOPADUR PHARMA AG
06/10/22
-
134
Compounds useful for treating gastrointestinal tract disorders
ARDELYX, INC.
06/10/22
-
2
Ethynyl derivatives
Hoffmann-La Roche Inc.
06/10/22
-
56
Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
06/10/22
-
174
Proteasome activity enhancing compounds
Proteostasis Therapeutics, Inc.
06/10/22
-
76
Pyrazolopyridine compounds and uses thereof
Incyte Corporation
06/10/22
-
90
Spirocyclic ROR-gamma modulators
ESCALIER BIOSCIENCES B.V.
06/10/22
-
61
Sulfonimidoylpurinone compounds and methods of treatment using the same
Hoffmann-La Roche Inc.
06/10/22
-
98
Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
06/10/22
-
6
Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
LANDSTEINER GENMED, S.L.
06/09/22
-
1
Formulations of an AXL/MER inhibitor
Incyte Corporation
06/09/22
-
21
Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2)
Medibiofarma, S.L.
06/09/22
-
95
Inhibitors of plasma kallikrein
Kalvista Pharmaceuticals Limited
06/09/22
-
4
Organosilicon carriers for use in treating infections and/or diseases caused by SARS viruses
TBA
06/09/22
-
3
Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
Translational Drug Development, LLC
06/06/22
-
274
Combination of isoindolinone derivatives with SGI-110
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
06/06/22
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
06/06/22
-
99
Fused ring compounds
Genentech, Inc.
06/06/22
-
134
Isoxazole compounds as inhibitors of heat shock proteins
Cancer Research Technology Limited; The Institute of Cancer Research; Vernalis (R&D) Limited
06/06/22
-
197
KIF18A inhibitors
AMGEN INC.
06/06/22
-
8
Morpholine derivates as inhibitors of Vps34
Neuropore Therapies, Inc.
06/06/22
-
77
Protein kinase B inhibitors
ASTRAZENECA AB
06/06/22
-
116
Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
MISSION THERAPEUTICS LIMITED
06/06/22
-
183
Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
Genentech, Inc.
06/06/22
-
6
Substituted pyrrolopyridines as ATR inhibitors
BlueValley Pharmaceutical LLC
06/06/22
-
36
Substituted sulfoximine compounds
Cadila Healthcare Limited
06/06/22
-
11
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
CrystalGenomics, Inc.
05/30/22
-
166
KDM1A inhibitors for the treatment of disease
Imago Biosciences, Inc.
05/30/22
-
99
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme Corp.
05/30/22
-
244
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
05/29/22
-
128
Myocyte enhancer factor 2 (MEF2) modulators
STANDARD LLC
05/29/22
-
32
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
05/29/22
-
38
Substituted tetrahydroquinolinone compounds as ROR gamma modulators
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
05/29/22
-
108
Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
Incyte Corporation; Incyte Holdings Corporation
05/29/22
-
15
Bicyclic inhibitors of histone deacetylase
Alkermes, Inc.
05/22/22
-
812
Compounds that inhibits MCL-1 protein
AMGEN INC.
05/22/22
-
18
Heterocycles useful as anti-cancer agents
Hangzhou Innogate Pharma Co., Ltd.
05/22/22
-
275
Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
Whitehead Institute for Biomedical Research; Dana-Farber Cancer Institute, Inc.; The United States of America, as represented by the Secretary, Department of Health and Human Services
05/22/22
-
10
Substituted pyridines as inhibitors of histone deacetylase
Alkermes, Inc.
05/22/22
-
122
Tertiary alcohols as PI3K-γ inhibitors
Incyte Corporation
05/22/22
-
16
5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
Temple University-Of the Commonwealth System of Higher Education
05/14/22
-
137
Cyclin dependent kinase inhibitors
Pfizer Inc.
05/14/22
-
333
Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
05/14/22
-
23
Pyridylpyridone compounds
Sprint Bioscience AB
05/14/22
-
30
Pyrrole tricyclic compounds as A2A / A2B inhibitors
Incyte Corporation
05/14/22
-
71
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics Incorporated
05/14/22
-
218
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
MIRATI THERAPEUTICS, INC.
05/14/22
-
93
Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
PFIZER INC.
05/14/22
-
217
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
05/14/22
-
4
2,3-dihydrofuro[2,3-b]pyridine compounds
Eli Lilly and Company
05/08/22
-
42
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
Incyte Holdings Corporation; Incyte Corporation
05/08/22
-
17
Cannabinoid receptor modulators
Arena Pharmaceuticals, Inc.
05/08/22
-
88
Compositions for treating neurodegenerative diseases
Cognition Therapeutics, Inc.
05/08/22
-
341
Compound, compositions, and methods
DENALI THERAPEUTICS INC.
05/08/22
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
SHY Therapeutics LLC
05/08/22
-
103
Histone demethylase inhibitors
CELGENE QUANTICEL RESEARCH, INC.
05/08/22
-
52
Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
NANJING HUAWE MEDICINE TECHNOLOGY GROUP CO., LTD.
05/08/22
-
21
Linear glycosidase inhibitors
Asceneuron SA
05/08/22
-
42
MAGL inhibitors
H. LUNDBECK A/S
05/08/22
-
16
Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
Boehringer Ingelheim International GmbH
05/08/22
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics, Incorporated
05/08/22
-
52
Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
JANSSEN PHARMACEUTICA NV
05/08/22
-
7
Substituted pyridine derivatives useful as C-FMS kinase inhibitors
Janssen Pharmaceutica NV
05/08/22
-
32
Compositions and methods for treating parasitic diseases
The Regents of the University of California; Washington University
05/03/22
-
109
Compounds useful as inhibitors of ALCAT 1
PERENNA PHARMACEUTICALS, INC.
05/03/22
-
80
Ectonucleotidase inhibitors and methods of use thereof
CALITHERA BIOSCIENCES, INC.
05/03/22
-
5
Nitrogenous tricyclic compounds and uses thereof in medicine
SUNSHINE LAKE PHARMA CO., LTD.
05/03/22
-
31
Prognostic biomarkers for TTK inhibitor chemotherapy
NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
05/03/22
-
20
Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
Sprint Bioscience AB
05/03/22
-
121
Pyridone derivatives having tetrahydropyranylmethyl groups
Daiichi Sankyo Company, Limited
05/03/22
-
41
Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
Prelude Therapeutics Incorporated
05/03/22
-
53
Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
Bayer Pharma Aktiengesellschaft; Bayer Aktiengesellschaft
05/03/22
-
376
Substituted indole Mcl-1 inhibitors
Vanderbilt University
05/03/22
-
20
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
Incyte Corporation; Incyte Holdings Corporation
05/02/22
-
119
3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
ALLERGAN, INC.
05/02/22
-
96
Certain chemical entities, compositions, and methods
NEUPHARMA, INC
05/02/22
-
27
HDAC6 inhibitors and imaging agents
The General Hospital Corporation
05/02/22
-
55
Indole derivatives and their use as protein kinase inhibitors
RESPIVERT LIMITED
05/02/22
-
204
Metallo-beta-lactamase inhibitors and methods of use thereof
Merck Sharp & Dohme Corp.
05/02/22
-
117
NLRP3 inflammasome inhibitors
Novartis AG
05/02/22
-
595
Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
JANSSEN PHARMACEUTICA NV
05/02/22
-
526
Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
05/02/22
-
1
Sulfinylpyridines and their use in the treatment of cancer
Oblique Therapeutics AB
05/02/22
-
243
Triazolopyrimidine compounds and uses thereof
Novartis AG
05/02/22
-
28
Anti-proliferative agents for treating PAH
Pfizer Inc.
04/29/22
-
13
Aza-indazole compounds for use in tendon and/or ligament injuries
NOVARTIS AG
04/29/22
-
247
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
04/29/22
-
37
Iridinesulfonamide compound and use method thereof
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
04/29/22
-
281
Kinase inhibitors and uses thereof
DENALI THERAPEUTICS INC.
04/29/22
-
14
Personal care compositions comprising fatty acid amide derivatives
Conopco, Inc.
04/29/22
-
302
Substituted 6-azabenzimidazole compounds
Gilead Sciences, Inc.
04/29/22
-
100
Sulfonamides as modulators of sodium channels
VERTEX PHARMACEUTICALS INCORPORATED
04/29/22
-
19
Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
The Broad Institute, Inc.; Biogen MA Inc.
04/29/22
-
56
Compounds targeting PRMT5
Aligos Therapeutics, Inc.
04/25/22
-
573
Fused ring derivative having MGAT-2 inhibitory activity
SHIONOGI & CO., LTD.
04/25/22
-
113
Aminopyrimidinyl compounds
Pfizer Inc.
04/24/22
-
16
Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
GLYCOMIMETICS. INC.
04/24/22
-
115
Heteroaryl inhibitors of PAD4
Padlock Therapeutics, Inc.
04/24/22
-
92
N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
KalVista Pharmaceuticals Limited
04/24/22
-
13
Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
BioAxone BioSciences, Inc.
04/24/22
-
30
5-hydroxytryptamine receptor 7 activity modulators and their method of use
Temple University-Of The Commonwealth System of Higher Education
04/17/22
-
111
Alkyl substituted triazole compounds as agonists of the APJ Receptor
AMGEN INC.
04/17/22
-
377
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica NV
04/17/22
-
8
Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
THE JOHNS HOPKINS UNIVERSITY
04/17/22
-
44
Heterocyclic compounds for the inhibition of PASK
BioEnergenix LLC
04/17/22
-
246
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
04/17/22
-
36
N-aryl oxamic acids
Purdue Research Foundation
04/17/22
-
6
Pyrazoloquinazolinone antitumor agents
The Rockefeller University
04/17/22
-
43
Quinoline compounds as modulators of RAGE activity and uses thereof
TBA
04/17/22
-
4
Quinolone compounds as inhibitors of the BCL6 BTB domain protein-protein interaction and/or as BCL6 degraders
ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR)
04/17/22
-
68
Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
Nuvation Bio Inc.
04/17/22
-
88
6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
SPRINT BIOSCIENCE AB
04/10/22
-
73
6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative
AYUMI PHARMACEUTICAL CORPORATION
04/10/22
-
40
Amino pyrimidine derivatives
Novartis AG
04/10/22
-
46
Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
ARIAD Pharmaceuticals, Inc.
04/10/22
-
14
Azaspiro[4.5]decane derivatives and use thereof
Purdue Pharma L.P.
04/10/22
-
8
Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
Jenrin Discovery, LLC
04/10/22
-
32
Compound as ACC inhibitor and use thereof
NANJING SANHOME PHARMACEUTICAL CO., LTD.
04/10/22
-
161
Compounds for the treatment of pain
TBA
04/10/22
-
4
Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor
Incyte Corporation
04/10/22
-
95
Cyanoindoline derivatives as NIK inhibitors
Janssen Pharmaceutica NV
04/10/22
-
145
Imidazopyrimidine derivatives
Gilead Sciences, Inc.
04/10/22
-
38
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme Corp.
04/10/22
-
59
Pyrazole derivatives as plasma kallikrein inhibitors
KalVista Pharmaceuticals Limited
04/10/22
-
130
Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
Aurigene Discovery Technologies Limited
04/10/22
-
23
Somatostatin modulators and uses thereof
CRINETICS PHARMACEUTICALS, INC.
04/10/22
-
562
Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors
Dart Neuroscience, (Cayman) LTD.
04/10/22
-
183
Substituted amino acids as integrin inhibitors
Pliant Therapeutics, Inc.
04/10/22
-
254
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
04/10/22
-
6
Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
Shenzhen TargetRx, Inc.
04/10/22
-
35
Therapeutic heterocyclic compounds
Gilead Sciences, Inc.
04/10/22
-
212
Vasopressin receptor antagonists and products and methods related thereto
BLACKTHORN THERAPEUTICS, INC.
04/10/22
-
13
[1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
ELI LILLY AND COMPANY
04/10/22
-
27
3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
Novartis AG
04/09/22
-
50
Methods for modulating taste receptors
MARS, INCORPORATED
04/09/22
-
64
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
Vertex Pharmaceuticals Incorporated
04/09/22
-
164
Non-fused tricyclic compounds
VIVACE THERAPEUTICS, INC.
04/09/22
-
45
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb Company
04/09/22
-
73
4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
Takeda Pharmaceutical Company Limited
04/03/22
-
8
Adrenergic receptor modulating compounds and methods of using the same
The Board of Trustees of the Leland Stanford Junior University
04/03/22
-
17
Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof
YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.; SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.
04/03/22
-
333
Benzenesulfonamide compouds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
04/03/22
-
124
Benzimidazole compounds and derivatives as EGFR inhibitors
Boehringer Ingelheim International GmbH
04/03/22
-
187
Bicyclic heterocycles as FGFR4 inhibitors
Incyte Corporation
04/03/22
-
59
Compositions and methods to modulate chloride ion channel activity
The Board of Trustees of the Leland Stanford Junior University
04/03/22
-
18
Compounds, compositions and methods
Denali Therapeutics Inc.
04/03/22
-
133
Heterocyclic compounds as kinase inhibitors
NUVATION BIO INC.
04/03/22
-
29
Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Merck Sharp & Dohme Corp.
04/03/22
-
303
Isoquinolin-3-yl carboxamides and preparation and use thereof
BioSplice Therapeutics, Inc.
04/03/22
-
7
Neprilysin inhibitors
Theravance Biopharma R&D IP, LLC
04/03/22
-
126
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Propellon Therapeutics Inc.
04/03/22
-
89
Substituted heterocyclyl derivatives as CDK inhibitors
Aurigene Discovery Technologies Limited
04/03/22
-
19
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
04/03/22
-
5
Matriptase inhibitors and uses thereof
SOCIÉTÉ DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES SANTÉ ET HUMAINES S.E.C.
03/30/22
-
11
3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman) Limited
03/27/22
-
71
3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
Board of Trustees of the Southern Illinois University
03/27/22
-
20
4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
Boehringer Ingelheim International GmbH
03/27/22
-
173
ASK1 inhibiting agents
BIOGEN MA INC.
03/27/22
-
13
Amino-triazolopyridine compounds and their use in treating cancer
AstraZeneca AB
03/27/22
-
135
Bicyclic heteroaryl compounds and uses thereof
Revolution Medicines, Inc.
03/27/22
-
35
CXCR2 antagonist
MEDSHINE DISCOVERY INC.
03/27/22
-
34
Compounds and their use for reducing uric acid levels
Acquist LLC
03/27/22
-
67
Dynamin-1-like protein inhibitors
Mitobridge, Inc.
03/27/22
-
10
Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
The Texas A&M University System
03/27/22
-
34
Fused pyrimidine derivatives as A2A / A2B inhibitors
Incyte Corporation
03/27/22
-
25
Fused ring derivative used as FGFR4 inhibitor
JACOBIO PHARMACEUTICALS CO., LTD.
03/27/22
-
214
Heteroaromatic derivatives as NIK inhibitors
Janssen Pharmaceutica NV
03/27/22
-
6
Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics AB
03/27/22
-
8
Indane-amines as PD-L1 antagonists
ChemoCentryx, Inc.
03/27/22
-
66
Inhibitors of Plasma Kallikrein and uses thereof
Takeda Pharmaceutical Company Limited
03/27/22
-
42
Inhibitors of dihydroceramide desaturase for treating disease
Centaurus Therapeutics
03/27/22
-
55
Inhibitors of integrated stress response pathway
PRAXIS BIOTECH LLC
03/27/22
-
118
JAK inhibitors
VIMALAN BIOSCIENCES, INC.
03/27/22
-
77
Macrocycles as factor XIA inhibitors
Bristol-Myers Squibb Company
03/27/22
-
42
Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
Boehringer Ingelheim International GmbH
03/27/22
-
56
Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
TBA
03/27/22
-
95
Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
03/27/22
-
7
Pyrrolopyrimidine and pyrrolopyridine derivatives
GALAPAGOS NV
03/27/22
-
96
Pyrrolopyrimidine derivatives as TAM inhibitors
Incyte Corporation
03/27/22
-
239
Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
03/27/22
-
38
Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Shanghai Hansoh Biomedical Co., Ltd.
03/27/22
-
115
Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
Array BioPharma Inc.
03/27/22
-
125
Therapeutic compounds and uses thereof
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
03/27/22
-
135
Thienopyridine inhibitors of RIPK2
Celgene Corporation
03/27/22
-
22
Thienopyrimidones
Boehringer Ingelheim International GmbH
03/27/22
-
186
2-quinolone derived inhibitors of BCL6
The Institute of Cancer Research: Royal Cancer Hospital; Cancer Research Technology Limited
03/20/22
-
15
Compounds and their use for reducing uric acid levels
Acquist LLC
03/20/22
-
37
Cyclic substituted imidazo[4,5-c]quinoline derivatives
PFIZER INC.
03/20/22
-
113
Fused pyrazine derivatives as A2A / A2B inhibitors
Incyte Corporation
03/20/22
-
13
Heterocyclic derivatives as PI3K inhibitors
Incyte Corporation
03/20/22
-
33
Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics AB
03/20/22
-
77
Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Merck Sharp & Dohme Corp.
03/20/22
-
6
Inhibiting the transient receptor potential al ion channel
Eli Lilly and Company
03/20/22
-
44
Inhibitors of NEK7 kinase
HALIA THERAPEUTICS, INC.
03/20/22
-
530
Purinones as ubiquitin-specific protease 1 inhibitors
FORMA Therapeutics, Inc.
03/20/22
-
48
Pyridinone derivatives and their use as selective ALK-2 inhibitors
NOVARTIS AG
03/20/22
-
76
Sting agonists
VENENUM BIODESIGN, LLC
03/20/22
-
97
Tricyclic fused thiophene derivatives as JAK inhibitors
Incyte Corporation; Incyte Holdings Corporation
03/20/22
-
71
4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof
SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
03/13/22
-
4
Amide derivatives as Nav1.7 and Nav1.8 blockers
RaQualia Pharma Inc.
03/13/22
-
66
Antagonists of the muscarinic acetylcholine receptor M4
Vanderbilt University
03/13/22
-
13
C7 substituted oxysterols and methods of use thereof
SAGE THERAPEUTICS, INC.
03/13/22
-
2
Crystal form of urate transporter 1 inhibitor and preparation method and use thereof
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.
03/13/22
-
129
Cyclopropylamines as LSD1 inhibitors
Incyte Corporation
03/13/22
-
30
Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
TOPADUR PHARMA AG
03/13/22
-
35
Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor
InflaRx GmbH
03/13/22
-
38
Fused triazole agonists of the APJ receptor
Amgen Inc.
03/13/22
-
57
Heterocycle comprising tyrosine kinase inhibitors
Principia Biopharma Inc.
03/13/22
-
46
MAP kinase modulators and uses thereof
The Trustees of Columbia University in the City of New York; Northwestern University
03/13/22
-
157
Oxysterols and methods of use thereof
SAGE THERAPEUTICS, INC.
03/13/22
-
1
Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
Arena Pharmaceuticals, Inc.
03/13/22
-
37
Pyrazole MAGL inhibitors
H. LUNDBECK A/S
03/13/22
-
140
Pyrazolopyrimidine compounds and methods of use thereof
Genentech, Inc.
03/13/22
-
17
Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
DANA-FARBER CANCER INSTITUTE, INC.
03/13/22
-
251
Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
Sanofi
03/13/22
-
272
Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
03/13/22
-
12
Substituted nucleosides, nucleotides and analogs thereof
JANSSEN BIOPHARMA, INC.
03/13/22
-
70
Substituted triazole derivatives and uses thereof
Bayer Pharma Aktiengesellschaft
03/13/22
-
33
Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
UNIVERSITÄT DUISBURG-ESSEN
03/13/22
-
15
Thrombospondin 1-binding peptide
DAIICHI SANKYO COMPANY, LIMITED; PEPTIDREAM INC.
03/13/22
-
8
Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
GENUV Inc.
03/12/22
-
17
Compositions and methods for treating CNS disorders
Sage Therapeutics, Inc.
03/12/22
-
2
Compounds as neurokinin-1 receptor antagonists and uses thereof
XWPHARMA LTD.
03/12/22
-
5
Methods for treating GI tract disorders
NEUROGASTRX, INC.
03/12/22
-
29
Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
Aurigene Discovery Technologies Limited
03/12/22
-
215
2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
BAYER AKTIENGELLSCHAFT; BAYER PHARMA AKTIEGELLSCHAFT; THE BROAD INSTITUTE INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
03/08/22
-
715
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
IDEAYA BIOSCIENCE, INC.
03/08/22
-
38
Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
Incyte Corporation
03/08/22
-
15
Calcium channel inhibitors
CAVION, INC.
03/08/22
-
78
Compounds
MISSION THERAPEUTICS LIMITED
03/08/22
-
60
Dual MAGL and FAAH inhibitors
Abide Therapeutics, Inc.
03/08/22
-
66
Pyridazinone compounds and their use as DAAO inhibitors
Takeda Pharmaceutical Company Limited
03/08/22
-
308
Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein
Prelude Therapeutics, Incorporated
03/08/22
-
17
Substituted 2,3-dihydro-1H-indene analogs and methods using same
Arbutus Biopharma Corporation
03/08/22
-
95
Substituted benzamides as RIPK2 inhibitors
Boehringer Ingelheim International GmbH
03/08/22
-
179
Azalactam compounds as HPK1 inhibitors
PFIZER INC.
03/04/22
-
61
Benzimidazoles and indoles as taro inhibitors
MERCK SHARP & DOHME CORP
03/04/22
-
58
Compositions for APP-selective BACE inhibition and uses therefor
The Regents of the University of California
03/04/22
-
13
Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
03/04/22
-
99
Dihydropyrimidine compounds and uses thereof in medicine
SUNSHINE LAKE PHARMA CO., LTD.
03/04/22
-
21
Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor
Hangzhou Innogate Pharma Co., Ltd.
03/04/22
-
35
Inhibitors of cyclin-dependent kinases
Dana-Farber Cancer Institute, Inc.
03/04/22
-
37
LDHA activity inhibitors
ARCTIC PHARMA AS
03/04/22
-
3
Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
Poxel SA
03/04/22
-
99
Oxazolidinones as taro inhibitors
MERCK SHARP & DOHME CORP
03/04/22
-
187
Spirocycle compounds and methods of making and using same
H. LUNDBECK A/S
03/04/22
-
51
Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
STINGRAY THERAPEUTICS, INC.
03/04/22
-
8
Inhibitors of bromodomain-containing protein 4 (BRD4)
Board of Regents, The University Of Texas System
03/02/22
-
34
2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
TBA
02/26/22
-
24
Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
DYNAVAX TECHNOLOGIES CORPORATION
02/26/22
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
ASTRAZENECA AB
02/26/22
-
3
Combination of pure 5-HT6 receptor antagonists with NMDA receptor antagonist
Suven Life Sciences Limited
02/26/22
-
546
Compounds useful as inhibitors of ATR kinase
VERTEX PHARMACEUTICALS INCORPORATED
02/26/22
-
38
Disubstituted pyrazole compounds
Eli Lilly and Company
02/26/22
-
33
Heterocyclic compounds as immunomodulators
Incyte Corporation
02/26/22
-
7
Imidazolidine compounds
Eli Lilly and Company
02/26/22
-
101
Inhibitors of glucocorticoid receptor
ORIC PHARMACEUTICALS, INC.
02/26/22
-
4
Isoquinolin and naphthydrin compounds
Eli Lilly and Company
02/26/22
-
184
Kappa opioid receptor antagonists and products and methods related thereto
THE SCRIPPS RESEARCH INSTITUTE; BLACKTHORN THERAPEUTICS, INC.
02/26/22
-
28
L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs
Recurium IP Holdings, LLC
02/26/22
-
635
Methods and compositions of inhibiting DCN1-UBC12 interaction
MEMORIAL SLOAN KETTERING CANCER CENTER; ST. JUDE CHILDREN''S RESEARCH HOSPITAL
02/26/22
-
62
Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics, Inc.
02/26/22
-
127
Phenylpyrrolidinone formyl peptide 2 receptor agonists
Bristol-Myers Squibb Company
02/26/22
-
7
Pyrazolo-heteroaryl derivative, preparation method and medical use thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
02/26/22
-
39
Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
TBA
02/26/22
-
22
Selective estrogen receptor degraders
Eli Lilly and Company
02/26/22
-
32
Tetrahydroisoquinolines and terahydronaphthyridines for the treatment of hepatitis B virus infection
Hoffmann-La Roche, Inc.
02/26/22
-
50
Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
Clavius Pharmaceuticals, LLC.
02/26/22
-
117
6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
University of Pittsburgh—Of the Commonwealth System of Higher Education
02/22/22
-
39
Inhibitor of apoptosis protein (IAP) antagonists
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
02/22/22
-
81
Pyrazolopyrimidine compounds and uses thereof
Incyte Corporation
02/22/22
-
12
Pyrimidine compounds and pyrimido indole compounds and methods of use
Duquesne University of The Holy Spirit
02/22/22
-
1227
6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
SHIONOGI & CO., LTD.
02/21/22
-
64
Amino pyrimidine compound for inhibiting protein tyrosine kinase activity
Shenzhen TargetRx, Inc.
02/21/22
-
71
Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb Company
02/21/22
-
23
Autotaxin inhibitors
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; UNIVERSITY OF MEMPHIS
02/21/22
-
250
Bicyclic compound and use thereof
SK BIOPHARMACEUTICALS CO., LTD.
02/21/22
-
164
Compounds, compositions, and methods
DENALI THERAPEUTICS INC.
02/21/22
-
53
EPAC antagonists
Board of Regents, the University of Texas System
02/21/22
-
17
Imidazopyrazine inhibitors of Bruton's tyrosine kinase
Acerta Pharma B.V.
02/21/22
-
62
Methods of treating mental disorders
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
02/21/22
-
43
Pyrimidine compounds as JAK kinase inhibitors
Theravance Biopharma R&D IP, LLC
02/21/22
-
314
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
Pfizer Inc.
02/21/22
-
27
Sultam compound and application method thereof
Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
02/21/22
-
27
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors
H. Lundbeck A/S
02/13/22
-
47
4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof
TBA
02/13/22
-
843
4-azaindole compounds
Bristol-Myers Squibb Company
02/13/22
-
13
4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament
Boehringer Ingelheim International GmbH
02/13/22
-
262
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences, Inc.
02/13/22
-
15
Benzimidazole derivatives, preparation methods and uses thereof
BETTA PHARMACEUTICALS CO., LTD.
02/13/22
-
199
Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme Corp.
02/13/22
-
20
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche Inc.; Chugai Pharmaceutical Co.
02/13/22
-
50
Inhibitors of hepatitis C virus replication
Merck Sharp & Dohme Corp.
02/13/22
-
26
JAK1 pathway inhibitors for the treatment of cytokine-related disorders
Incyte Corporation
02/13/22
-
379
KRAS G12C inhibitors and methods of using the same
AMGEN INC.
02/13/22
-
223
Macrocyclic compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
02/13/22
-
21
PTPN11 inhibitors
NAVIRE PHARMA, INC.
02/13/22
-
188
Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases
Array BioPharma Inc.
02/13/22
-
14
Pyridazines
Boehringer Ingelheim International GmbH
02/13/22
-
138
Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
02/13/22
-
8
Pyrimidinones as factor XIA inhibitors
Bristol-Myers Squibb Company
02/13/22
-
10
Pyrrolo[1,2-b]pyridazine derivatives
Gilead Sciences, Inc.
02/13/22
-
2
Salts of TAM inhibitors
Incyte Corporation
02/13/22
-
106
Substituted pyridines as TYK2 inhibitors
Esker Therapeutics, Inc.
02/13/22
-
233
Substituted tricyclic compounds as FGFR inhibitors
Incyte Corporation; Incyte Holdings Corporation
02/13/22
-
96
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
02/13/22
-
156
[9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
Neurocrine Biosciences, Inc.
02/13/22
-
71
5-alkyl pyrrolidine orexin receptor agonists
Merck Sharp & Dohme Corp.
02/07/22
-
64
Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffmann-La Roche Inc.
02/07/22
-
149
Bicyclic ketone compounds and methods of use thereof
Genentech, Inc.
02/07/22
-
113
Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft
02/07/22
-
116
Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
Pharmaxis Ltd.
02/07/22
-
179
Heteroaryl compounds as BTK inhibitors and uses thereof
Merck Patent GmbH
02/07/22
-
103
Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
1ST Biotherapeutics, Inc.
02/07/22
-
126
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
02/07/22
-
126
MK2 inhibitors and uses thereof
Celgene CAR LLC
02/07/22
-
32
Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
02/07/22
-
40
Macrocyclic compounds as TRK kinase inhibitors and uses thereof
ANGEX PHARMACEUTICAL, INC.
02/07/22
-
26
PRMT5 inhibitors
Merck Sharp & Dohme Corp.
02/07/22
-
4
Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
ARENA PHARMACEUTICALS, INC.
02/07/22
-
116
1-cyano-pyrrolidine compounds as USP30 inhibitors
MISSION THERAPEUTICS LIMITED
02/06/22
-
10
Anti-HIV compounds
Gilead Sciences, Inc.
02/06/22
-
184
Aryl-or heteroaryl-substituted benzene compounds
Epizyme, Inc.
02/06/22
-
21
BRK inhibitory compound
ONO PHARMACEUTICAL CO., LTD.
02/06/22
-
165
Carbazole derivatives
Bristol-Myers Squibb Company
02/06/22
-
49
Combination therapies using immuno-dash inhibitors and PGE2 antagonists
Trustees of Tufts College
02/06/22
-
36
Compounds and methods of use
Medivation Technologies LLC
02/06/22
-
47
Heterocyclic compounds and uses thereof
Celgene CAR LLC
02/06/22
-
168
Heterocyclic compounds useful as Pim kinase inhibitors
Incyte Corporation
02/06/22
-
18
Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
02/06/22
-
252
Pharmaceutical compounds
ALMAC DISCOVERY LIMITED
02/06/22
-
19
Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
Merck Sharp & Dohme Corp.; IOmet Pharma Ltd.
02/06/22
-
26
Substituted indoline derivatives as dengue viral replication inhibitors
Janssen Pharmaceuticals, Inc.; Kathalieke Universiteif Leuven
02/06/22
-
96
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte Corporation
02/02/22
-
129
CXCR7 antagonists
ChemoCentryx, Inc.
02/02/22
-
25
Compounds and compositions useful for treating disorders related to NTRK
Blueprint Medicines Corporation
02/02/22
-
10
Compounds that participate in cooperative binding and uses thereof
Revolution Medicines, Inc.
02/02/22
-
60
Difluoroketamide derivatives as HtrA1 inhibitors
Hoffmann-La Roche Inc.
02/02/22
-
376
Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators
Janssen Pharmaceutica NV
02/02/22
-
25
MAGL inhibitors
H. LUNDBECK A/S
02/02/22
-
24
Macrocyclic immunomodulators
ChemoCentryx, Inc.
02/02/22
-
30
Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
University of South Carolina
02/02/22
-
15
Small molecule inhibitors of the JAK family of kinases
Janssen Pharmaceutica NV
02/02/22
-
30
Substituted purines as TLR7 agonists
Primmune Therapeutics, Inc.
02/02/22
-
56
Triazolopyridine inhibitors of myeloperoxidase
Bristol-Myers Squibb Company
02/02/22
-
78
1-cyano-pyrrolidine derivatives as inhibitors of USP30
MISSION THERAPEUTICS LIMITED
01/30/22
-
4
Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
UCB Biopharma SRL
01/30/22
-
6
Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
01/30/22
-
7
Hydantoins that modulate BACE-mediated app processing
BUCK INSTITUTE FOR RESEARCH ON AGING
01/30/22
-
40
Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor
SHENGKE PHARMACEUTICALS (JIANGSU) LTD.
01/30/22
-
200
Isoxazolyl ether derivatives as GABAA α5 PAM
Hoffmann-La Roche Inc.
01/30/22
-
63
Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
ARDELYX, INC.
01/30/22
-
113
PI-kinase inhibitors with anti-infective activity
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
01/30/22
-
46
Protein kinase inhibitors, preparation method and medical use thereof
Gan & Lee Pharmaceuticals
01/30/22
-
70
SHMT inhibitors and uses thereof
RAZE THERAPEUTICS, INC.
01/30/22
-
218
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
MIRATI THERAPEUTICS, INC.
01/30/22
-
270
Tricyclic heterocycles as BET protein inhibitors
Incyte Corporation
01/30/22
-
20
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics Corporation
01/24/22
-
27
Cyanopyrrolidine derivatives with activity as inhibitors of USP30
MISSION THERAPEUTICS LIMITED
01/24/22
-
92
N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
KalVista Pharmaceuticals Limited
01/24/22
-
107
Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
01/24/22
-
51
Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
01/24/22
-
26
Salts and processes of preparing a PI3K inhibitor
Incyte Corporation
01/24/22
-
51
Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors
Daewoong Pharmaceutical Co., Ltd.
01/24/22
-
713
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
IDEAYA BIOSCIENCES, INC.
01/23/22
-
565
Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
01/23/22
-
33
Benzofuran derivative, preparation method thereof and use thereof in medicine
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
01/23/22
-
6
Ethynyl derivatives
Hoffmann-La Roche Inc.
01/23/22
-
70
Heterocyclic compounds useful as dual ATX/CA inhibitors
Hoffmann-La Roche Inc.
01/23/22
-
28
Imidazolyl tricyclic enones as antioxidant inflammation modulators
REATA PHARMACEUTICALS, INC.
01/23/22
-
122
Imidazopiperazine inhibitors of transcription activating proteins
Board of Regents, The University of Texas System
01/23/22
-
9
Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
Regents of the University of Colorado, a body corporate; Colorado Research Partners. LLC
01/23/22
-
118
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research, Inc.
01/23/22
-
21
Isoquinoline-steroid conjugates and uses thereof
Aerie Pharmaceuticals, Inc.
01/23/22
-
84
Methods to induce targeted protein degradation through bifunctional molecules
DANA-FARBER CANCER INSTITUTE, INC.
01/23/22
-
31
Oxime ether compounds
Bristol-Myers Squibb Company
01/23/22
-
21
Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
PHARMAKEA, INC.
01/23/22
-
7
ROR-gamma modulators and uses thereof
PIRAMAL ENTERPRISES LIMITED
01/23/22
-
12
Substituted bicyclic compounds
Bristol-Myers Squibb Company
01/23/22
-
7
Substituted cyanopyrrolidines with activity as DUB inhibitors
MISSION THERAPEUTICS LIMITED
01/23/22
-
158
5-membered and bicyclic heterocyclic amides as inhibitors of rock
Bristol-Myers Squibb Company
01/16/22
-
17
6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
SPRINT BIOSCIENCE AB
01/16/22
-
14
Amino-fluoropiperidine derivatives as kinase inhibitor
Daewoong Pharmaceutical Co., Ltd.
01/16/22
-
69
Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
TBA
01/16/22
-
39
Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
01/16/22
-
201
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences, Inc.
01/16/22
-
32
Heteroaromatic compounds as Vanin inhibitors
Boehringer Ingelheim International GmbH
01/16/22
-
13
Heteroaryl amides as inhibitors of protein aggregation
UCB Biophama SRL
01/16/22
-
51
Heterocyclic derivatives as PI3K inhibitors
Incyte Corporation
01/16/22
-
17
Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same
Duquesne University of The Holy Spirit
01/16/22
-
155
Quinolone derivatives as fibroblast growth factor receptor inhibitors
PRINCIPIA BIOPHARMA, INC.
01/16/22
-
155
ROR γ modulators
Bristol-Myers Squibb Company
01/16/22
-
3
Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
Yeda Research and Development Co. Ltd.
01/16/22
-
42
Selective inhibitors of protein arginine methlytransferase 5 (PRMT5)
Prelude Therapeutics, Incorporated
01/16/22
-
819
Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists