-
Patent
Data
Compounds
HGNC
(for human-derived proteins)
Patent Title
Organization
Deposition
Downloads
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229
COMPOUNDS
Enterprise Therapeutics Ltd
01/13/22
-
179
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences, Inc.
01/13/22
-
117
Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
PHARMAKEA, INC.
01/09/22
-
29
1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
Addex Pharmaceuticals S.A.; Janssen Pharmaceuticals, Inc.
01/07/22
-
21
Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
BAYER PHARMA AKTIENGESELLSCHAFT
01/07/22
-
101
Bicyclic amide compounds and methods of use thereof
Genentech, Inc.
01/07/22
-
223
Bicyclic sulfones and sulfoxides and methods of use thereof
Genentech, Inc.
01/07/22
-
215
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GALAPAGOS NV
01/07/22
-
41
Inhibitors of RIP1 kinase and methods of use thereof
Genentech, Inc.
01/07/22
-
13
Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
Celon Pharma S.A.
01/07/22
-
31
Small molecule inhibitors of Galectin-3
Bristol-Myers Squibb Company
01/07/22
-
201
Substituted 6-azabenzimidazole compounds
Gilead Sciences, Inc.
01/07/22
-
275
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Epics Therapeutics
01/07/22
-
146
2,2-difluorodioxolo A2A receptor antagonists
Merck Sharp & Dohme Corp.
12/28/21
-
19
Androgen receptor modulating compounds
ORION CORPORATION
12/28/21
-
26
Galactoside inhibitor of galectins
GALECTO BIOTECH AB
12/28/21
-
175
Glycosidase inhibitors
Asceneuron SA
12/28/21
-
198
Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
SK BIOPHARMACEUTICALS CO., LTD.
12/28/21
-
48
Sulfonamide compounds
Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute
12/28/21
-
45
2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
DOMPÉ FARMACEUTICI S.P.A.
12/27/21
-
729
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
IDEAYA BIOSCIENCES, INC.
12/27/21
-
5
Alkylphenyl compounds
Bristol-Myers Squibb Company
12/27/21
-
127
Aminopyrazine derivatives as PI3K-γ inhibitors
Incyte Corporation
12/27/21
-
26
Azetidine derivative, preparation method therefor, and use thereof
SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
12/27/21
-
148
Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
Board of Regents, The University of Texas System
12/27/21
-
12
Dihydropyrimidinyl benzazepine carboxamide compounds
Hoffmann-La Roche Inc.
12/27/21
-
39
Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof
Beijing Innocare Pharma Tech Co., Ltd
12/27/21
-
198
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
12/27/21
-
436
Heteroaryl-substituted triazoles as APJ receptor agonists
AMGEN INC.
12/27/21
-
36
Hydroxamic acids comprising pyrazole moiety and uses thereof
HAWAII BIOTECH, INC.
12/27/21
-
70
Indolinones compounds and their use in the treatment of fibrotic diseases
RespiVert Limited
12/27/21
-
202
Inhibitor compounds
Cancer Research Technology Limited
12/27/21
-
35
Piperazine substituted azapine derivatives and uses thereof
ALAIRION, INC.
12/27/21
-
27
Piperazinyl norbenzomorphan compounds and methods for using the same
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
12/27/21
-
41
Piperidines as covalent menin inhibitors
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
12/27/21
-
208
Piperidinyl-3-(aryloxy)propanamides and propanoates
Takeda Pharmaceutical Company Limited
12/27/21
-
159
Selective estrogen receptor down-regulators
AstraZeneca AB
12/27/21
-
8
Substituted isoquionline derivatives as immunomudulators
Bristol-Myers Squibb Company
12/27/21
-
33
Substituted piperidines for the treatment of cancer
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD
12/27/21
-
1145
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
12/27/21
-
30
Thiadiazole IRAK4 compounds
Gilead Sciences, Inc.
12/27/21
-
271
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics Limited
12/23/21
-
964
Cot modulators and methods of use thereof
Gilead Sciences, Inc.
12/23/21
-
57
Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
12/20/21
-
211
Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
SHIONOGI & CO., LTD.
12/20/21
-
6
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
Incyte Corporation
12/20/21
-
15
Small molecule inhibitors of the JAK family of kinases
Janssen Pharmaceutica NV
12/20/21
-
478
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
MERCK SHARP & DOHME CORP.
12/19/21
-
329
Arylquinazolines
MERCK PATENT GMBH
12/19/21
-
55
Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
ARVINAS OPERATIONS, INC.
12/19/21
-
26
Diacylglycerol acyl transferase 2 inhibitor
Pfizer Inc.
12/19/21
-
102
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
12/19/21
-
13
Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
DANA-FARBER CANCER INSTITUTE, INC.
12/19/21
-
987
Benzimidazole-proline derivatives
IDORSIA PHARMACEUTICALS LTD
12/14/21
-
135
Metalloenzyme inhibitor compounds
PHASEBIO PHARMACEUTICALS, INC.
12/14/21
-
10
Methods of identifying SENP1 inhibitors
CITY OF HOPE
12/14/21
-
17
Pyridine derivative as ASK1 inhibitor and preparation method and use thereof
TBA
12/14/21
-
11
Quinazoline compound for EGFR inhibition
MEDSHINE DISCOVERY INC.
12/14/21
-
32
Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
Principia Biopharma Inc.
12/14/21
-
4
Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
Blueprint Medicines Corporation
12/14/21
-
11
TYK2 inhibitors, uses, and methods for production thereof
Nimbus Lakshmi, Inc.
12/14/21
-
42
VMAT2 inhibitor compounds and compositions thereof
Neurocrine Biosciences, Inc.
12/14/21
-
146
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences, Inc.
12/06/21
-
11
Farnesoid X receptor modulators
Intercept Pharmaceuticals, Inc.
12/06/21
-
5
Methods to determine KDM1A target engagement and chemoprobes useful therefor
Oryzon Genomics S.A.
12/06/21
-
99
Apoptosis signal-regulating kinase inhibitors and uses thereof
SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
12/05/21
-
100
Carboxamide-pyrimidine derivatives as SHP2 antagonists
Merck Patent GmbH
12/05/21
-
551
Compounds of formulas (VII), (VIII), (IX), (XI), (XII), (XIII), and (XIV) as muscarinic receptor 4(M4) antagonists for treating neurological diseases
Neurocrine Biosciences, Inc.
12/05/21
-
16
Diacylglycerol acyl transferase 2 inhibitors
Pfizer Inc.
12/05/21
-
17
Ethynyl derivatives
Hoffmann-La Roche Inc.
12/05/21
-
52
Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
Nikang Therapeutics, Inc.
12/05/21
-
390
Naphthyridines as inhibitors of HPK1
Genentech, Inc.
12/05/21
-
53
Poly-ADP ribose polymerase (PARP) inhibitors
Mitobridge, Inc.
12/05/21
-
94
Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech, Inc.
12/05/21
-
65
Pyridinyl pyrazoles as modulators of RORγT
Janssen Pharmaceutica NV
12/05/21
-
366
Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders
THE SCRIPPS RESEARCH INSTITUTE
12/05/21
-
67
Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
Merck Sharp & Dohme Corp.
12/05/21
-
825
Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
Nimbus Saturn, Inc.
12/05/21
-
35
1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
Merck Patent GmbH
11/29/21
-
166
1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
Amgen Inc.
11/29/21
-
192
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck A/S
11/29/21
-
3
3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
CTXT PTY LTD
11/29/21
-
205
4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
ARRAY BIOPHARMA INC.; CELGENE CORPORATION
11/29/21
-
35
Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
Bristol-Myers Squibb Company
11/29/21
-
6
Cyclic dinucleotides as sting agonists
Janssen Biotech, Inc.
11/29/21
-
145
Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
Board of Regents, The University of Texas System
11/29/21
-
134
Heteroaryl inhibitors of PAD4
Padlock Therapeutics, Inc.
11/29/21
-
7
Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics AB
11/29/21
-
12
Heterocyclic compounds as adenosine antagonists
NUVATION BIO INC.
11/29/21
-
23
Indolizine derivatives and their application in medicine
KIND PHARMACEUTICAL
11/29/21
-
97
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research, Inc.
11/29/21
-
131
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences, Inc.
11/29/21
-
34
Piperidinyl-propanone derivatives
Merck Patent GmbH
11/29/21
-
18
Second generation GRP94-selective inhibitors
University of Kansas
11/29/21
-
36
Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
Merck Sharp & Dohme Corp.
11/29/21
-
812
Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
Nimbus Saturn, Inc.
11/29/21
-
823
Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists
Nimbus Saturn, Inc.
11/29/21
-
60
Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
Merck Sharp & Dohme Corp.
11/29/21
-
36
Substituted pyrimidines as LRKK2 inhibitors
DENALI THERAPEUTICS INC.
11/29/21
-
7
Tetrahydroquinoline-based bromodomain inhibitors
St. Jude Children''s Research Hospital
11/29/21
-
90
Therapeutic compounds and methods of use thereof
Genentech, Inc.
11/29/21
-
145
Therapeutic inhibitory compounds
ATTUNE PHARMACEUTICALS, INC.
11/29/21
-
207
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals, Inc.
11/29/21
-
76
Tricyclic heterocyclic derivatives and uses thereof
AUCKLAND UNISERVICES LIMITED
11/29/21
-
42
Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.
11/29/21
-
491
[1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient
Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology
11/29/21
-
299
Amino-pyrrolopyrimidinone compounds and methods of use thereof
ArQule, Inc.
11/28/21
-
169
Biaryloxy derivatives as TTX-S blockers
RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.
11/28/21
-
150
Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
11/28/21
-
44
Compounds and their use for reducing uric acid levels
Acquist LLC
11/28/21
-
115
Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
AMGEN INC.
11/28/21
-
396
Therapeutic compounds
CELGENE QUANTICEL RESEARCH, INC.
11/28/21
-
27
Type of aryl benzofuran amidated derivative and medical use thereof
CHINA PHARMACEUTICAL UNIVERSITY
11/28/21
-
36
2,6-disubstituted pyridine derivative
SUMITOMO DAINIPPON PHARMA CO., LTD.
11/22/21
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte Corporation
11/22/21
-
569
CDK2 inhibitors
Pfizer Inc.
11/22/21
-
68
Cyanopyrrolidine derivatives with activity as inhibitors of USP30
MISSION THERAPEUTICS LIMITED
11/22/21
-
35
Factor XIIa inhibitors
Merck Sharp & Dohme Corp.
11/22/21
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
11/22/21
-
72
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer Inc.
11/22/21
-
9
LSD1 inhibitors and medical uses thereof
Constellation Pharmaceuticals, Inc.
11/22/21
-
126
Pyrazolopyrimidine compounds and uses thereof
Incyte Corporation
11/22/21
-
800
Pyridazinones as PARP7 inhibitors
Ribon Therapeutics, Inc.
11/22/21
-
30
Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit MNK1 and MNK2
eFFECTOR Therapeutics, Inc.
11/22/21
-
79
Triazolopyrimidine, triazolopyridine compounds, and the composition thereof for treating PRC2-mediated diseases
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.
11/22/21
-
202
Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
Hoffmann-La Roche Inc.
11/22/21
-
25
C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme Corp.
11/15/21
-
155
Compounds and methods for modulating interleukin-2-inducible t-cell kinase
Corvus Pharmaceuticals, Inc.
11/15/21
-
8
Compounds useful for inhibiting RORγt
Eli Lilly and Company
11/15/21
-
8
Cycloalkyl-diamines for the treatment of pain
MediSynergics, LLC
11/14/21
-
21
Piperidinone formyl peptide 2 receptor agonists
Bristol-Myers Squibb Company
11/14/21
-
359
Pyridazine derivatives as RORc modulators
Genentech, Inc.
11/14/21
-
420
Quinazolinones as PARP14 inhibitors
Ribon Therapeutics Inc.
11/14/21
-
85
Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
11/14/21
-
15
1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
ASTRAZENECA AB
11/08/21
-
8
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
Eli Lilly and Company
11/08/21
-
88
Alkyl pyrrolopyrimidine analogs and methods of making and using same
The University of North Carolina at Chapel Hill
11/08/21
-
6
Aminopyrimidinecarboxamides as CXCR2 modulators
Syntrix Biosystems Inc.
11/08/21
-
899
Benzolactam compounds as protein kinase inhibitors
OTSUKA PHARMACEUTICAL CO., LTD.
11/08/21
-
11
Compound useful for the treatment of degenerative and inflammatory diseases
GALAPAGOS NV
11/08/21
-
59
Compounds and their uses as ACC inhibitors
Nanjing Ruijie Pharmatech Co., Ltd.
11/08/21
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
Shy Therapeutics LLC
11/08/21
-
22
Difluoroketamide derivatives as HTRA1 inhibitors
Hoffman-La Roche Inc.
11/08/21
-
16
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals, LLC
11/08/21
-
13
Disubstituted compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
11/08/21
-
44
Histone demethylase inhibitors
CELGENE QUANTICEL RESEARCH, INC.
11/08/21
-
92
N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
KALVISTA PHARMACEUTICALS LIMITED
11/08/21
-
51
Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
ASTRAZENECA AB
11/08/21
-
13
Pyrimidine compounds and pyrimido indole compounds and methods of use
Duquesne University of The Holy Spirit
11/08/21
-
10
Pyrimidine derivative, method for preparing same and use thereof in medicine
TBA
11/08/21
-
136
Pyrimidinone derivatives as SHP2 antagonists
Merck Patent GmbH
11/08/21
-
81
SSAO inhibitor
TBA
11/08/21
-
15
Acetyl-CoA carboxylase modulators
Monsanto Technology LLC
11/04/21
-
108
EGFR proteolysis targeting chimeric molecules and associated methods of use
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY
11/04/21
-
57
Inhibitors of protease-activated receptor-2
Heptares Therapeutics Limited
11/04/21
-
162
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
11/04/21
-
218
PARG inhibitory compounds
Cancer Research Technology Limited
11/04/21
-
116
Pyrrolidine derivative
KISSEI PHARMACEUTICAL CO., LTD.
11/04/21
-
19
Substituted dihydrobenzofuran glycosidase inhibitors
Asceneuron SA
11/04/21
-
92
Zaindole derivatives and their use as ERK kinase inhibitors
AGV DISCOVERY; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE MONTPELLIER
11/04/21
-
53
1,2,4-triazine-4-amine derivatives
Heptares Therapeutics Limited
11/01/21
-
32
Alpha-D-galactoside inhibitors of galectins
GALECTO BIOTECH AB
11/01/21
-
70
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
11/01/21
-
77
Bicyclic lactams and methods of use thereof
Genentech, Inc.
11/01/21
-
136
Compounds
AstraZeneca AB
11/01/21
-
99
IRAK4 inhibitor and use thereof
BEIJING HANMI PHARMACEUTICAL CO., LTD.
11/01/21
-
2
Immunomodulators
bristol-myers squibb company
11/01/21
-
23
Inhibitors of influenza virus replication and uses thereof
SUNSHINE LAKE PHARMA CO., LTD.
11/01/21
-
440
MCL-1 inhibitors
Gilead Sciences, Inc.
11/01/21
-
20
Potent and selective mu opioid receptor modulators
Virginia Commonwealth University
11/01/21
-
37
Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
Japan Tobacco Inc.
11/01/21
-
532
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech, Inc.
11/01/21
-
55
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer Inc.
11/01/21
-
204
Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
Merck Sharp & Dohme Corp.
11/01/21
-
140
Substituted pyrimidines as cyclin-dependent kinase inhibitors
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
11/01/21
-
229
Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
Daewoong Pharmaceutical Co., Ltd.
10/27/21
-
25
Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
DART NEUROSCIENCE, LLC
10/27/21
-
1
Substituted thiohydantoin derivatives as androgen receptor antagonists
Janssen Pharmaceutica NV
10/27/21
-
11
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb Companay
10/27/21
-
61
1,3,4-thiadiazole compounds and their use in treating cancer
Cancer Research Technology Limited
10/26/21
-
18
6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
Purdue Research Foundation
10/26/21
-
113
Aminopyrimidinyl compounds
Pfizer Inc.
10/26/21
-
25
Benzothiophene estrogen receptor modulators
G1 Therapeutics, Inc.
10/26/21
-
236
Biaryl kinase inhibitors
Bristol-Myers Squibb Company
10/26/21
-
19
Compound for inhibiting IDO, a manufacturing method and a use thereof
Shanghai JOYU Pharmatech Ltd.
10/26/21
-
8
FXR (NR1H4) modulating compounds
Gilead Sciences, Inc.
10/26/21
-
49
Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
10/26/21
-
210
Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
Janssen Pharmaceutica NV
10/26/21
-
22
Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
10/26/21
-
5
Inhibitors of soluble adenylyl cyclase
Cornell University; Tri-Institutional Therapeutics Discovery Institute
10/26/21
-
85
Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
10/26/21
-
329
PRMT5 inhibitors and uses thereof
Epizyme, Inc.
10/26/21
-
51
Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
ACLARIS THERAPEUTICS, INC.
10/26/21
-
30
Therapeutic inhibitory compounds
ATTUNE PHARMACEUTICALS, INC.
10/26/21
-
164
Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
Bristol-Myers Squibb Company
10/26/21
-
95
Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
10/26/21
-
135
4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
TBA
10/20/21
-
92
6-aminopyridin-3-yl pyrazoles as modulators of RORgT
Janssen Pharmaceutica NV
10/20/21
-
440
6-aminopyridin-3-yl thiazoles as modulators of RORγT
Janssen Pharmaceutica NV
10/20/21
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25
Bis-heteroaryl derivatives as modulators of protein aggregation
UCB Biopharma SRL
10/20/21
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71
Compounds and compositions for inhibiting the activity of SHP2
NOVARTIS AG
10/20/21
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28
Grp94 selective inhibitors and uses thereof
University of Kansas; University of South Florida
10/20/21
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134
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent GmbH
10/20/21
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4
Imidazolyl kinase inhibitors and uses thereof
Dana-Farber Cancer Institute, Inc.
10/20/21
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185
KDM5 inhibitors
Merck Sharp & Dohme Corp.
10/20/21
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22
Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
10/20/21
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146
Pharmaceutical compounds
SENTINEL ONCOLOGY LIMITED
10/20/21
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225
Phenyl substituted pyrazoles as modulators of RORγt
Janssen Pharmaceutica NV
10/20/21
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150
Pyridine derivative
Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.
10/20/21
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27
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
10/20/21
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16
Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
10/20/21
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644
Substituted pyridines as inhibitors of DNMT1
GlaxoSmithKline Intellectual Property Development Limited; Cancer Research Technology Ltd.
10/20/21
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297
4,5-annulated 1,2,4-triazolones
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
10/09/21
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34
Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
The Research Foundation for the State University of New York
10/09/21
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114
Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
1st Biotherapeutics, Inc.
10/09/21
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35
Biaryltriazole inhibitors of macrophage migration inhibitory factor
Yale University
10/09/21
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29
Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
10/09/21
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35
Cyclopentane-based modulators of STING (stimulator of interferon genes)
Pfizer Inc.
10/09/21
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107
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical Company Limited
10/09/21
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155
Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
Proximagen, LLC
10/09/21
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45
Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
10/09/21
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13
Macrocyclic compounds as ROS1 kinase inhibitors
Array BioPharma Inc.
10/09/21
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189
Pyrido five-element aromatic ring compound, preparation method therefor and use thereof
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
10/09/21
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273
Pyrrolo[2,3-d]pyrimidine derivatives
Pfizer Inc.
10/09/21
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13
Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
Incyte Corporation
10/09/21
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22
Synergistic combination of immunologic inhibitors for the treatment of cancer
The University of Chicago
10/09/21
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91
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
10/09/21
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23
Therapeutic compounds and uses thereof
Kala Pharmaceuticals, Inc.
10/09/21
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90
USP30 inhibitors
Mitobridge, Inc.
10/09/21
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63
(S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor
AstraZeneca AB
10/04/21
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66
Chemical compounds
AstraZeneca AB
10/04/21
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80
Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
LegoChem Biosciences, Inc.
10/04/21
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66
Farnesoid X receptor agonists and uses thereof
METACRINE, INC.
10/04/21
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145
Inhibiting agents for Bruton's tyrosine kinase
BIOGEN MA INC.
10/04/21
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66
JAK1 selective inhibitors
ASTRAZENECA AB
10/04/21
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21
Modulators of the sigma-2 receptor and their method of use
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
10/04/21
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45
Oxazole derivatives for use in the treatment of cancer
LIFEARC
10/04/21
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3
PRMT5 inhibitors
CTXT PTY LTD
10/04/21
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180
Pyrazolopyrimidine derivatives as kinase inhibitor
Daewoong Pharmaceutical Co., Ltd.
10/04/21
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34
Quinazoline and indole compounds to treat medical disorders
Achillion Pharmaceuticals, Inc.
10/04/21
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512
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
10/04/21
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568
Substituted pyrazines as ATR kinase inhibitors
VERTEX PHARMACEUTICALS INCORPORATED
10/04/21
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119
Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
CELGENE QUANTICEL RESEARCH, INC.
10/04/21
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145
1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; NATIONAL INSTITUTES OF HEALTH, UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES
09/28/21
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75
1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
09/28/21
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27
Azaindoles as inhibitors of HPK1
Genentech, Inc.
09/28/21
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90
BMP-signal-inhibiting compound
RIKEN; THE UNIVERSITY OF TOKYO
09/28/21
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11
Compounds and uses thereof
Kala Pharmaceuticals, Inc.
09/28/21
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60
Compounds inhibiting leucine-rich repeat kinase enzyme activity
Merck Sharp & Dohme Corp.
09/28/21
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108
Heterocyclic compounds as ret kinase inhibitors
Cancer Research Technology Limited
09/28/21
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239
Heterocyclic compounds for the inhibition of pask
BioEnergenix LLC
09/28/21
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19
JAK inhibitors containing a 4-membered heterocyclic amide
Theravance Biopharma R&D IP, LLC
09/28/21
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261
Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
Theravance Biopharma R&D IP, LLC
09/28/21
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97
Methods of treating intraocular pressure with activators of Tie-2
AERPIO PHARMACEUTICALS, INC.
09/28/21
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444
Pyrazole derivatives as MALT1 inhibitors
Janssen Pharmaceutica NV
09/28/21
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15
Selective NR2B antagonists
Bristol-Myers Squibb Company
09/28/21
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43
Sigma receptor binders
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
09/28/21
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22
Substituted heterocyclic inhibitors of PTPN11
NAVIRE PHARMA, INC.
09/28/21
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134
Substituted indole Mcl-1 inhibitors
Vanderbilt University
09/28/21
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556
Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
Array Biopharma Inc.
09/28/21
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88
1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
ST. JUDE CHILDREN''S RSEARCH HOSPITAL
09/26/21
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87
Aminopyridine derivatives and their use as selective ALK-2 inhibitors
NOVARTIS AG
09/26/21
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4
Beta adrenergic agonist and methods of using the same
CuraSen Therapeutics, Inc.
09/26/21
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54
Bicyclic heterocycles as FGFR inhibitors
Incyte Corporation; Incyte Holdings Corporation
09/26/21
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23
Bicyclic pyridone lactams and methods of use thereof
Genentech, Inc.
09/26/21
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3
Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body
Pfizer Inc.; iTEOS THERAPEUTICS
09/26/21
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12
Dimethyl amino azetidine amides as JAK inhibitors
Theravance Biopharma R&D IP, LLC
09/26/21
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79
Heteroaryl SYK inhibitors
Boehringer Ingelheim International GmbH
09/26/21
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449
Heteroaryl compounds and their use as therapeutic drugs
Dong-A Socio Holdings Co., Ltd.
09/26/21
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72
Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme Corp.
09/26/21
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135
Inhibitors of Hepatitis C virus polymerase
COCRYSTAL PHARMA, INC.
09/26/21
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547
Inhibitors of KEAP1-Nrf2 protein-protein interaction
Janssen Pharmaceutica NV
09/26/21
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33
Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease
TBA
09/26/21
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12
PRMT5 inhibitors
Merck Sharp & Dohme Corp.
09/26/21
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26
Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
Seoul National University Hospital
09/26/21
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18
Substituted oxazines as beta-secretase inhibitors
Amgen Inc.
09/26/21
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11
Tank-binding kinase-1 PROTACs and associated methods of use
ARVINAS OPERATIONS, INC.
09/26/21
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38
Therapeutic compounds and methods of use thereof
GENENTECH, INC.
09/26/21
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391
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals, Inc.
09/26/21
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6
Treatment and diagnosis of melanoma
The Rockefeller University
09/26/21
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1
[1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
Janssen Pharmaceutica NV
09/26/21
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26
Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
09/20/21
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499
Bromodomain inhibitors
Celgene Quanticel Research, Inc.
09/20/21
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29
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Ogeda SA
09/20/21
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25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
Shy Therapeutics LLC
09/20/21
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8
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals, Inc.
09/20/21
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72
Kinase inhibitors
Oxular Acquisitions Limited
09/20/21
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31
Methods for inhibiting fascin
NOVITA PHARMACEUTICALS, INC.; CORNELL UNIVERSITY
09/20/21
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88
Quinoline and isoquinoline derivatives for treating pain and pain related conditions
ESTEVE PHARMACEUTICALS, S.A.
09/20/21
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131
4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
Merck Sharp & Dohme B.V.
09/12/21
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143
5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
Samumed, LLC
09/12/21
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28
Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
09/12/21
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214
Bruton's tyrosine kinase inhibitors
Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.
09/12/21
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61
Compounds and compositions for inhibiting the activity of SHP2
NOVARTIS AG
09/12/21
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472
Inhibitors of Bruton's tyrosine kinase and method of their use
Janssen Pharmaceutica NV
09/12/21
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236
Pyrazolopyridine compounds and uses thereof
Incyte Corporation
09/12/21
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32
SHMT inhibitors
The Trustees of Princeton University
09/12/21
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288
SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics, Inc.
09/12/21
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87
Spirocyclic compounds
Recurium IP Holdings, LLC
09/12/21
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60
Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
Merck Sharp & Dohme Corp.
09/12/21
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44
Benzothiazole derivatives as DYRK1 inhibitors
PHARMASUM THERAPEUTICS AS
09/06/21
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45
CDK inhibitors
GI Therapeutics, Inc.
09/06/21
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31
Cyano-subtituted heterocycles with activity as inhibitors of USP30
MISSION THERAPEUTICS LIMITED
09/06/21
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48
HSP90B N-terminal isoform-selective inhibitors
University of Kansas
09/06/21
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62
Inhibitors of RAF kinases
KINNATE BIOPHARMA INC.
09/06/21
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69
Intermediate compound of novel tetrahydronaphthyl urea derivative
MOCHIDA PHARMACEUTICAL CO., LTD.
09/06/21
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35
Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
Arena Pharmaceuticals, Inc.
09/06/21
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112
Oxadiazaspiro compounds for the treatment of drug abuse and addiction
ESTEVE PHARMACEUTICALS. S.A.
09/06/21
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248
Pyrazole MAGL inhibitors
LUNDBECK LA JOLLA RESEARCH CENTER, INC.
09/06/21
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48
Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
Merck Sharp & Dohme Corp.
09/06/21
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7
Treatment of conditions associated with hyperinsulinaemia
Tensha Therapeutics, Inc.
09/06/21
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26
Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International
09/06/21
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8
Amide compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals, Inc.
09/02/21
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18
Azetidine derivatives
Vernalis (R&D) Ltd.
09/02/21
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56
Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International GmbH
09/02/21
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9
Cannabidiol derivatives as inhibitors of the HIF prolyl hydroxylases activity
Emerald Health Pharmaceuticals Inc.
09/02/21
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463
Compounds and uses thereof
Yumanity Therapeutics, Inc.
09/02/21
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18
Cyclohexene compounds and use thereof
GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD.
09/02/21
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6
Fused imidazoles as mIDH1 inhibitors
BAYER PHARMA AKTIENGESELLSCHAFT
09/02/21
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23
Hetero-halo inhibitors of histone deacetylase
Alkermes, Inc.
09/02/21
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3
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals, Inc.
09/02/21
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5
Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
Incyte Holdings Corporation; Incyte Corporation
09/02/21
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12
Imidazopyrazine compounds, preparation methods and uses thereof
DONGGUAN ZHENXING-BEITE MEDICINE TECHNOLOGY CO., LTD.
09/02/21
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407
Immunomodulator compounds
ChemoCentryx, Inc.
09/02/21
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68
N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
Nerviano Medical Sciences S.R.L.
09/02/21
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1
Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GALAPAGOS NV
09/02/21
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56
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
Boehringer Ingelheim International GmbH
09/02/21
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51
Substituted tricyclic heterocyclic compounds and use thereof
LIFEARC; SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD.
09/02/21
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49
Thiazole derivative and applications
EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
09/02/21
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70
Thioacetate compounds, compositions and methods of use
Ardea Biosciences, Inc
09/02/21
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37
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb Company
09/02/21
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80
Tricyclic ASK1 inhibitors
TERNS, INC.
09/02/21
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99
Benzene disulfonamide for the treatment of cancer
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
08/30/21
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14
Bis-heteroaryl derivatives as modulators of protein aggregation
UCB Biopharma SRL
08/30/21
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107
Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
H. Lundbeck A/S
08/30/21
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16
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D IP, LLC
08/30/21
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20
LRRK2 inhibitors and methods of making and using the same
DANA-FARBER CANCER INSTITUTE, INC.
08/30/21
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47
Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
Hoffmann-La Roche Inc.
08/30/21
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110
Oxadiazolones as transient receptor potential channel inhibitors
Genentech, Inc.
08/30/21
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59
Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
08/30/21
-
67
Pyrimidine FGFR4 inhibitors
EISAI R&D MANAGEMENT CO., LTD.
08/30/21
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111
Substituted 4-phenylpiperidines, their preparation and use
The Trustees of Columbia University in the City of New York
08/30/21
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50
Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.
08/30/21
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219
Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
VALO EARLY DISCOVERY, INC.
08/30/21
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111
Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
H. Lundbeck A/S
08/22/21
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42
Compositions and methods for inhibiting kinases
Inhibikase Therapeutics, Inc.
08/22/21
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14
Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D''ORLEANS; UNIVERSITE DE TOURS; CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
08/22/21
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52
Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/22/21
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65
Heterocyclic compounds as immunomodulators
Incyte Corporation
08/22/21
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7
Kinase inhibitors for the treatment of disease
DANA FARBER CANCER INSTITUTE, INC.
08/22/21
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198
Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
Pfizer Inc.
08/22/21
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20
Substituted piperazines as ROR-gamma modulators
ESCALIER BIOSCIENCES B.V.
08/22/21
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370
Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
LEO Pharma A/S
08/22/21
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103
Triazole phenyl compounds as agonists of the APJ receptor
AMGEN INC.
08/22/21
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34
IRAK4 modulators
Genentech, Inc.
08/16/21
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71
IRAK4 modulators
Genentech, Inc.
08/16/21
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4
3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/15/21
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32
Benzothiazole compounds and uses thereof
Incyte Corporation
08/15/21
-
33
Imidazo isoindole derivative, preparation method therefor and medical use thereof
JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHRMACEUTICAL CO., LTD.
08/15/21
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124
Imidazopiperazinone inhibitors of transcription activating proteins
Board of Regents, The University of Texas System
08/15/21
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110
Inhibiting agents for Bruton's tyrosine kinase
BIOGEN MA INC.
08/15/21
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427
PD-1/PD-L1 inhibitors
Gilead Sciences, Inc.
08/15/21
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23
Phosphodiesterase inhibitors and uses thereof
The Trustees of Columbia University in the City of New York
08/15/21
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378
Piperidines as menin inhibitors
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
08/15/21
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38
Pyrazine compounds and uses thereof
TBA
08/15/21
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49
Antitumor drug for intermittent administration of FGFR inhibitor
Taiho Pharmaceutical Co., Ltd.
08/14/21
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51
Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors
Nikang Therapeutics, Inc.
08/14/21
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165
Halo-substituted piperidines as orexin receptor modulators
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
08/14/21
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648
Heteroarylbenzimidazole compounds
BAYER PHARMA AKTIENGESELLSCHAFT
08/14/21
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35
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System; ChemPartner Corporation
08/14/21
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19
Indolizine derivatives, composition and methods of use
SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.
08/14/21
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161
Inhibitors of cyclin-dependent kinases
KINNATE BIOPHARMA INC.
08/14/21
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120
Modulators of P97 AAA ATPase activity
University of Pittsburgh—Of the Commonwealth System of Higher Education
08/14/21
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4
Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
NANOMEDSYN; Centre National de la Recherche Scientifique; Universite de Montpellier
08/14/21
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102
PSMA imaging agents
Siemens Medical Solutions USA, Inc.
08/14/21
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3
Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics
King Abdulaziz University
08/14/21
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46
Substituted pyrazole derivatives as selective CDK12/13 inhibitors
Aurigene Discovery Technologies Limited
08/14/21
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74
Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof
Jiangsu Hengrui Medicine Co., Ltd.
08/09/21
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22
Alpha-D-galactoside inhibitors of galectins
GALECTO BIOTECH AB
08/09/21
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157
Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
Array BioPharma Inc.
08/09/21
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14
CGRP receptor antagonists
Heptares Therapeutics Limited
08/09/21
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32
Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
08/09/21
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40
Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
Amgen Inc.
08/09/21
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29
Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
ONCOZEN CO.. LTD.
08/09/21
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95
Inhibitors of TRPC6
Boehringer Ingelheim International GmbH
08/09/21
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78
Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
Auckland UniServices Limited
08/09/21
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69
PDE9 inhibitor and use thereof
Nanjing TransThera Biosciences Co. Ltd.
08/09/21
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215
Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias
Terns, Inc.
08/09/21
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268
Sulfonamide compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
08/09/21
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52
Tetrahydroindazoles and medical uses thereof
Genase Therapeutics B.V.
08/09/21
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17
Thiazine derivatives as β-secretase inhibitors and methods of use
Amgen Inc.
08/09/21
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21
Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
VALO EARLY DISCOVERY, INC.
08/09/21
-
7
[1,3]thiazin-2-amine compound, application, and pharmaceutical composition
TETRANOV PHARMACEUTICAL CO., LTD.
08/09/21
-
33
Pyrazole derivatives as MALT1 inhibitors
Janssen Pharmaceutica NV
08/08/21
-
6
Acetamide thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute, Inc.
08/01/21
-
17
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche Inc.
08/01/21
-
61
Cannabinergic compounds and uses thereof
NORTHEASTERN UNIVERSITY
08/01/21
-
48
Compounds useful as immunomodulators
Bristol-Myers Squibb Company
08/01/21
-
27
KDM1A inhibitors for the treatment of disease
Imago Biosciences, Inc.
08/01/21
-
3
Kinase inhibitors
TOPIVERT PHARMA LIMITED
08/01/21
-
22
Pharmaceutical compounds
Sareum Limited
08/01/21
-
16
Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
08/01/21
-
137
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
Boehringer Ingelheim International GmbH
08/01/21
-
812
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma Inc.
08/01/21
-
19
Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
ONO PHARMACEUTICAL CO., LTD.
08/01/21
-
8
Tyrosine kinase inhibitor and application thereof
LaNova Medicines Limited
08/01/21
-
25
Compounds and their use as BACE1 inhibitors
ALLGENESIS BIOTHERAPEUTICS, INC.
07/26/21
-
40
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Dana-Farber Cancer Institute, Inc.
07/26/21
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138
Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
SHIONOGI & CO., LTD.
07/26/21
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825
Pyridazinones as PARP7 inhibitors
Ribon Therapeutics, Inc.
07/26/21
-
18
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
HANMI PHARM. CO.. LTD.
07/26/21
-
10
Zwitterionic propargyl-linked antifolates useful for treating bacterial infections
UNIVERSITY OF CONNECTICUT
07/26/21
-
9
Aminopyrazoles as selective janus kinase inhibitors
Intervet Inc.
07/25/21
-
2
Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB
07/25/21
-
4
Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
Aristea Translational Medicine Corporation
07/25/21
-
91
Compositions and methods of modulating short-chain dehydrogenase activity
CASE WESTERN RESERVE UNIVERSITY; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
07/25/21
-
23
Compounds and methods for inhibiting CYP26 enzymes
Queen''s University at Kingston
07/25/21
-
90
Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
Boehringer Ingelheim International GmbH
07/25/21
-
174
Factor XIIa inhibitors
MERCK SHARP & DOHME CORP.
07/25/21
-
151
Heteroaromatic compounds as BTK inhibitors
Boehringer Ingelheim International GmbH
07/25/21
-
3
Highly active compounds against COVID-19
Atea Pharmaceuticals, Inc.
07/25/21
-
30
Histone deacetylase inhibitors and uses thereof
MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
07/25/21
-
26
N4-hydroxycytidine and derivatives and anti-viral uses related thereto
Emory University
07/25/21
-
16
Neuroprotective agents for treatment of neurodegenerative diseases
WAYNE STATE UNIVERSITY
07/25/21
-
22
Phosphonate linkers and their use to facilitate cellular retention of compounds
MERCK SHARP & DOHME CORP.
07/25/21
-
34
Pteridine dione monocarboxylate transporter inhibitors
THE SCRIPPS RESEARCH INSTITUTE
07/25/21
-
25
RIPK2 inhibitors and method of treating cancer with same
UNIVERSITY HEALTH NETWORK
07/25/21
-
102
Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC.
07/25/21
-
3
Substituted pyrimidines for treating bacterial infections
FORGE THERAPEUTICS, INC.
07/25/21
-
136
Substituted pyrrolizine compounds and uses thereof
GILEAD SCIENCES, INC.
07/25/21
-
34
Triazolopyridines
Hoffmann-La Roche Inc.
07/25/21
-
23
Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
Hoffmann-La Roche Inc.
07/25/21
-
47
2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
Agency for Science, Technology and Research; National University of Singapore
07/18/21
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229
ATG7 inhibitors and the uses thereof
MILLENNIUM PHARMACEUTICALS, INC.
07/18/21
-
3
Dab2 inhibitors for the prevention and treatment of cystic fibrosis
TRUSTEES OF DARTMOUTH COLLEGE
07/18/21
-
17
Difluoroketamide derivatives as HtrA1 inhibitors
Hoffmann-La Roche Inc.
07/18/21
-
57
Heteroaromatic compounds as Vanin inhibitors
Boehringer Ingelheim International GmbH
07/18/21
-
15
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Syros Pharmaceuticals, Inc.
07/18/21
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75
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research, Inc.
07/18/21
-
12
Opioid agonists and uses thereof
Nektar Therapeutics
07/18/21
-
7
Pet imaging agents
Novartis AG
07/18/21
-
39
Biaryl urea derivative or salt thereof and preparation process and use for the same
FUDAN UNIVERSITY
07/13/21
-
116
Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl
Hoffmann-La Roche Inc.
07/13/21
-
140
Arf6 inhibitors and methods of synthesis and use thereof
Navigen, Inc.; The University of Utah Research Foundation
07/12/21
-
185
Benzoimidazoles as prolyl hydroxylase inhibitors
Janssen Pharmaceutica NV
07/12/21
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377
Benzopyrazole compounds and analogues thereof
BioCryst Pharmaceuticals, Inc.
07/12/21
-
21
Benzoxazepin oxazolidinone compounds and methods of use
Genentech, Inc.
07/12/21
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43
Bicyclic amines as novel JAK kinase inhibitors
LEO Pharma A/S
07/12/21
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12
Bicyclic heterocycles as FGFR4 inhibitors
Incyte Corporation
07/12/21
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64
C3-carbon linked glutarimide degronimers for target protein degradation
C4 Therapeutics, Inc.
07/12/21
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92
Heterocyclic inhibitors of PTPN11
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
07/12/21
-
52
Imidazole and triazole containing bicyclic compounds as JAK inhibitors
Theravance Biopharma R&D IP, LLC
07/12/21
-
30
Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
Foresee Pharmaceuticals Co., Ltd.
07/12/21
-
31
Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds
Array Biopharma Inc.
07/12/21
-
3
Pyridine compound
Daiichi Sankyo Company, Limited
07/12/21
-
227
Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2)
Northwestern University
07/12/21
-
7
Substituted bicyclic heterocyclic compounds
Bristol-Myers Squibb Company
07/12/21
-
118
Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
CELGENE QUANTICEL RESEARCH, INC.
07/12/21
-
112
Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
Boehringer Ingelheim International GmbH
07/11/21
-
26
Diarylalkanes as potent inhibitors of binuclear enzymes
Unigen, Inc.
07/11/21
-
3
HDAC inhibitors for the treatment of diabetic peripheral neuropathy
REGENACY PHARMACEUTICALS, LLC
07/11/21
-
6
Heterocyclic ring derivatives useful as SHP2 inhibitors
JACOBIO PHARMACEUTICALS CO., LTD.
07/11/21
-
53
Heterocyclic spiro compounds as MAGL inhibitors
Pfizer Inc.
07/11/21
-
20
Hydantoin containing deoxyuridine triphosphatase inhibitors
CV6 Therapeutics (NI) Limited
07/11/21
-
3
Imidazopyrazine inhibitors of Bruton's tyrosine kinase
Acerta Pharma B.V.
07/11/21
-
111
Imidazopyrazinones as PDE1 inhibitors
H. Lundbeck A/S
07/11/21
-
34
Inhibitors of phosphatidylinositol 3-kinase gamma
AstraZeneca AB
07/11/21
-
22
Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; PRAEVENTIX, LLC
07/11/21
-
5
Oxazoline pseudodimers, pharmaceutical compositions and the use thereof
PURDUE PHARMA L.P.
07/11/21
-
80
Pyrazolopyridine derivative having GLP-1 receptor agonist effect
Chugai Seiyaku Kabushiki Kaisha
07/11/21
-
98
Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof
UNIVERSITY OF MARYLAND, BALTIMORE
07/11/21
-
119
Triazolo-pyrimidine compounds and uses thereof
TBA
07/11/21
-
41
Tricyclic compounds useful to treat orthomyxovirus infections
Novartis AG
07/11/21
-
16
1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions
SABILA BIOSCIENCES LLC
07/06/21
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63
Fused amino pyridine as HSP90 inhibitors
Curis, Inc.
07/06/21
-
86
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology Limited
07/06/21
-
100
Imidazopyridines Syk inhibitors
KRONOS BIO, INC.
07/06/21
-
13
Process for preparing JAK inhibitors and intermediates thereof
Theravance Biopharma R&D IP, LLC
07/06/21
-
92
Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof
Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.
07/06/21
-
146
Pyrrolotriazine compounds as TAM inhibitors
Incyte Corporation
07/06/21
-
107
Serine/threonine kinase inhibitors
GENENTECH, INC.
07/06/21
-
271
Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors
Vanderbilt University
07/06/21
-
22
Thiazolyl-containing compounds for treating proliferative diseases
Dana-Farber Cancer Institute, Inc.
07/06/21
-
359
WDR5 inhibitors and modulators
Vanderbilt University
07/06/21
-
12
5 to 7 membered heterocyclic amides as JAK inhibitors
Theravance Biopharma R&D IP, LLC
06/30/21
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55
5-HT2C receptor agonists and compositions and methods of use
Arena Pharmaceuticals, Inc.
06/30/21
-
6
6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
Eli Lilly and Company
06/30/21
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73
Acyl sulfonamide NaV1.7 inhibitors
BRISTOL-MYERS SQUIBB COMPANY
06/30/21
-
57
Bicyclic heterocyclic derivatives
Merck Patent GmbH
06/30/21
-
58
Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
06/30/21
-
13
Inhibitors of integrin alpha 5 beta 1 and methods of use
The Regents of the University of California
06/30/21
-
47
N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Ogeda SA
06/30/21
-
15
N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
Neomed Institute
06/30/21
-
12
Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
Valo Early Discovery, Inc.
06/30/21
-
11
Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
Mebias Discovery, Inc.
06/30/21
-
55
Substituted pyrrolizine compounds and uses thereof
GILEAD SCIENCES, INC.
06/30/21
-
50
Therapeutic agent for FGFR inhibitor-resistant cancer
Taiho Pharmaceutical Co., Ltd.
06/30/21
-
22
N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
06/29/21
-
51
2,4-pyrimidinediamine compounds and their uses
Rigel Pharmceuticals, Inc.
06/28/21
-
153
3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives
GRUENENTHAL GMBH
06/28/21
-
150
5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis
GALAPAGOS NV
06/28/21
-
50
Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
06/28/21
-
155
Aryl sulfonohydrazides
MONASH UNIVERSITY; The Walter and Eliza Hall Institute of Medical Research
06/28/21
-
189
Benzimidazole derivatives as modulators of ROR-gamma
Vitae Pharmaceuticals, LLC
06/28/21
-
149
Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors
Boehringer Ingelheim International GmbH
06/28/21
-
23
Compositions and methods for treating KIT- and PDGFRA-mediated diseases
Blueprint Medicines Corporation
06/28/21
-
7
Crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
KRONOS BIO, INC.
06/28/21
-
7
Neprilysin inhibitors
Theravance Biopharma R&D IP, LLC
06/28/21
-
5
Pyridyl-triazabicycles
Hoffmann-La Roche Inc.
06/28/21
-
82
Pyrimidinones as PI3K inhibitors
Incyte Corporation; Incyte Holdings Corporation
06/28/21
-
22
Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACAD
06/28/21
-
244
Substituted 2,4-diaminopyrimidines as kinase inhibitors
Celgene CAR LLC
06/28/21
-
111
Substituted benzoimidazoles as modulators of ROR-γ
Vitae Pharmaceuticals, LLC
06/28/21
-
9
Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents
GI Therapeutics, Inc.
06/28/21
-
108
Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
Incyte Corporation; Incyte Holdings Corporation
06/28/21
-
27
Thienopyridines and benzothiophenes useful as IRAK4 inhibitors
Bristol-Myers Squibb Company
06/28/21
-
103
Thiophene, manufacturing method thereof, and pharmaceutical application of same
CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD.; CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD.; CSTONE PHARMACEUTICALS
06/28/21
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703
Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
06/21/21
-
2
Crystal of DPP-IV long-acting inhibitor and salt
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.
06/21/21
-
30
ErbB receptor inhibitors
TBA
06/21/21
-
789
Inhibitors of Bruton's tyrosine kinase and methods of their use
Janssen Pharmaceutica NV
06/21/21
-
63
KV1.3 inhibitors and their medical application
4SC AG
06/21/21
-
1
Processes for preparing ATR inhibitors
VERTEX PHARMACEUTICALS INCORPORATED
06/21/21
-
37
Pyrazolo[1,5-a]pyrazin-4-yl derivatives
Pfizer Inc.
06/21/21
-
12
Pyrazolopyrimidine derivatives as NIK inhibitors
Janssen Pharmaceutica NV
06/21/21
-
74
Substituted aminoquinazoline compounds as A2A antagonist
Merck Sharp & Dohme Corp.
06/21/21
-
797
Compounds that inhibit Mcl-1 protein
AMGEN INC.
06/20/21
-
115
Histone demethylase inhibitors
CELGENE QUANTICEL RESEARCH, INC.
06/14/21
-
10
Isoidide derivatives and methods of making and using same
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
06/14/21
-
10
Optically active azabicyclo ring derivative
Sumitomo Dainippon Pharma Co., Ltd.
06/14/21
-
31
1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
Respivert Limited
06/13/21
-
215
2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
06/13/21
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325
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
06/13/21
-
140
Bruton's tyrosine kinase inhibitors
Pfizer Inc.
06/13/21
-
4
Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
06/13/21
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90
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals, Inc.
06/13/21
-
107
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
Incyte Corporation; Incyte Holdings Corporation
06/13/21
-
17
Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
Pfizer Inc.
06/13/21
-
192
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck A/S
06/11/21
-
382
3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
Grünenthal GmbH
06/11/21
-
289
3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
GRÜNENTHAL GMBH
06/11/21
-
104
Bromodomain inhibitors
Celgene Quanticel Research, Inc.
06/11/21
-
59
Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use
Merck Sharp & Dohme Corp.
06/11/21
-
124
Compositions useful for treating disorders related to kit
Blueprint Medicines Corporation
06/11/21
-
101
Compounds for treatment of immune inflammatory disorders
Achillion Pharmaceuticals, Inc.
06/11/21
-
51
Dihydrochromene derivatives
Sumitomo Dainippon Pharma Co., Ltd.
06/11/21
-
156
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals, LLC
06/11/21
-
200
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
06/11/21
-
42
HDAC inhibitor compounds and methods of treatment
University of Florida Research Foundation, Inc.; The Scripps Research Institute
06/11/21
-
97
Heterocyclic compounds and uses thereof
NUVATION BIO INC.
06/11/21
-
16
Heterocyclic compounds as kinase inhibitors
Translational Drug Development, LLC
06/11/21
-
101
Histone demethylase inhibitors
CELGENE QUANTICEL RESEARCH, INC.
06/11/21
-
191
Immunomodulator compounds and methods of use
Incyte Corporation
06/11/21
-
161
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
The Institute of Cancer Research: Royal Cancer Hospital
06/11/21
-
28
Protease inhibitors having enhanced features
Nektar Therapeutics
06/11/21
-
17
Pyrrolidinone compounds
Eli Lilly and Company
06/11/21
-
51
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
University of Tennessee Research Foundation
06/11/21
-
42
Spiro-cyclic amine derivatives as S1P modulators
AbbVie B.V.; AbbVie, Inc.
06/11/21
-
260
WDR5-MLL1 inhibitors and modulators
Vanderbilt University
06/11/21
-
38
2,6-disubstituted pyridine derivative
SUMITOMO DAINIPPON PHARMA CO., LTD.
06/01/21
-
20
4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors
NERVIANO MEDICAL SCIENCES S.R.L.
06/01/21
-
155
5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
Leo Pharma A/S
06/01/21
-
20
Arylpropionyl-triketone antibacterial agents
TBA
06/01/21
-
40
Beta-lactamase inhibitor compounds
Entasis Therapeutics Limited
06/01/21
-
32
Bicyclic compounds as ATX inhibitors
Hoffman-La Roche Inc.
06/01/21
-
218
CDK2/4/6 inhibitors
Pfizer Inc.
06/01/21
-
105
Carboxamide compounds and uses thereof
Incyte Corporation
06/01/21
-
22
Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor
TBA
06/01/21
-
7
Conjugate comprising a neurotensin receptor ligand and use thereof
3B Pharmaceuticals GMBH
06/01/21
-
25
Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
06/01/21
-
138
Heterocyclic compounds as LSD1 inhibitors
Incyte Corporation
06/01/21
-
266
Heterocyclic compounds as immunomodulators
Incyte Corporation
06/01/21
-
122
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System; ChemPartner Corporation
06/01/21
-
32
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System; ChemPartner Corporation
06/01/21
-
12
Hybrid galactoside inhibitor of galectins
TBA
06/01/21
-
41
Imidazole derivatives as formyl peptide receptor modulators
ALLERGAN, INC.
06/01/21
-
62
Indole derivative used as CRTH2 inhibitor
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
06/01/21
-
912
Inhibitors of Bruton's tyrosine kinase and method of their use
Janssen Pharmaceutica NV
06/01/21
-
94
Inhibitors of TRPC6
Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC
06/01/21
-
9
Methotrexate adjuvants to reduce toxicity and methods for using the same
Tosk, Inc.
06/01/21
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123
Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof
JAPAN TOBACCO INC.
06/01/21
-
11
Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
BAYER PHARMA AKTIENGESELLSCHAFT
06/01/21
-
7
Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
ACLARIS THERAPEUTICS, INC.
06/01/21
-
6
Substituted pyridine derivatives useful as C-FMS kinase inhibitors
Janssen Pharmaceutica NV
06/01/21
-
85
Substituted pyrrolo[2,3-d]pyridazin-4-ones and pyrazolo[3,4-d]pyridazin-4-ones as protein kinase inhibitors
Shanghai Fochon Pharmaceutical Co., Ltd.; Fochon Pharmaceuticals, Ltd.
06/01/21
-
7
Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders
Northwestern University
06/01/21
-
36
Thyroid hormone receptor beta agonist compounds
Terns, Inc.
06/01/21
-
179
Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
ALLERGAN, INC.
06/01/21
-
2
1,8-naphthyridinone compounds and uses thereof
NUVATION BIO INC.
05/14/21
-
73
3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
GRÜNENTHAL GMBH
05/14/21
-
34
8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
GRUENENTHAL GMBH
05/14/21
-
144
Amino acid compounds and methods of use
PLIANT THERAPEUTICS, INC.
05/14/21
-
3
Amino pyrimidine ssao inhibitors
ELI LILLY AND COMPANY
05/14/21
-
84
Bicyclic heterocyclic compound
MITSUBISHI TANABE PHARMA CORPORATION
05/14/21
-
15
Bicyclic inhibitors of histone deacetylase
Rodin Therapeutics, Inc.
05/14/21
-
361
Bicyclic-fused heteroaryl or aryl compounds
Pfizer Inc.
05/14/21
-
123
Bruton's tyrosine kinase inhibitors
ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
05/14/21
-
126
Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof
CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.
05/14/21
-
502
GCN2 inhibitors and uses thereof
MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED
05/14/21
-
19
Glutamine transport inhibitors and methods for treating cancer
Vanderbilt University
05/14/21
-
4
Heterocyclic compounds as immunomodulators
Incyte Corporation
05/14/21
-
45
Heterocyclic glutaminase inhibitors
Calithera Biosciences, Inc.
05/14/21
-
336
Hormone receptor modulators for treating metabolic conditions and disorders
ARDELYX, INC.
05/14/21
-
59
Oxoisoquinoline derivatives
CARNA BIOSCIENCES, INC.
05/14/21
-
7
Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.
05/14/21
-
22
Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
Bayer Pharma Aktiengesellschaft
05/14/21
-
15
Substituted nucleosides, nucleotides and analogs thereof
Janssen BioPharma, Inc.
05/14/21
-
310
Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
LEO Pharma A/S
05/14/21
-
4
Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators
ARENA PHARMACEUTICALS, INC.
05/14/21
-
59
Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof
SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
05/14/21
-
217
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
05/14/21
-
555
Compounds useful as inhibitors of ATR kinase
VERTEX PHARMACEUTICALS INCORPORATED
05/11/21
-
56
ASK1 inhibitor and preparation method and use thereof
Fuijan Cosunter Pharmaceutical Co. Ltd.
05/09/21
-
9
Benzopiperdine derivatives and their use in the treatment of cancer and hemoglobinopathies
CTXT PTY, LTD
05/09/21
-
3
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche Inc.
05/09/21
-
90
Cannabinoid receptor mediating iminopyrazole compounds
The United States of America, as represented by the Secretary, Department of Health and Human Services
05/09/21
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
05/09/21
-
40
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Dana-Farber Cancer Institute, Inc.
05/09/21
-
2
Octahydropyrrolopyrroles their preparation and use
The Trustees of Columbia University in the City of New York
05/09/21
-
23
Prodrugs of pyridone amides useful as modulators of sodium channels
Vertex Pharmaceuticals Incorporated
05/09/21
-
253
Spiro-fused cyclic ureas as inhibitors of rock
Bristol-Myers Squibb Company
05/09/21
-
18
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer Inc.
05/09/21
-
105
Thiazolidinedione derivative and use thereof
INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY
05/09/21
-
93
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte Corporation
05/03/21
-
2
2,6-diamino pyridine compounds
Eli Lilly and Company
05/03/21
-
4
3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals, Inc.
05/03/21
-
10
Azetidinyloxyphenylpyrrolidine compounds
Eli Lilly and Company
05/03/21
-
6
Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
05/03/21
-
108
Heterocyclic compounds for the inhibition of PASK
BioEnergenix LLC
05/03/21
-
108
N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
KALVISTA PHARMACEUTICALS LIMITED
05/03/21
-
260
Spirocycle compounds and methods of making and using same
LUNDBECK LA JOLLA RESEARCH CENTER, INC.
05/03/21
-
163
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
05/03/21
-
137
Therapeutic inhibitory compounds
ATTUNE PHARMACEUTICALS, INC.
05/03/21
-
25
Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
05/02/21
-
151
Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
Merck Sharp & Dohme Corp.
05/02/21
-
352
Heteroaryl compounds useful as inhibitors of SUMO activating enzyme
Millennium Pharmaceuticals, Inc.
05/02/21
-
3
Macrocycle and composition comprising thereof
Shenzhen TargetRx, Inc.
05/02/21
-
7
Mu opioid receptor modulators
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FRIEDRICH-ALEXANDER-UNIVERSITÄT; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
05/02/21
-
287
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Epics Therapeutics
05/02/21
-
242
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck A/S
04/26/21
-
83
2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
Array Biopharma Inc.
04/26/21
-
9
Aminopyrazoles as janus kinase inhibitors
Merck Sharp & Dohme Corp.
04/26/21
-
13
Aza-indazole compounds for use in tendon and/or ligament injuries
NOVARTIS AG
04/26/21
-
137
Cyclin dependent kinase inhibitors
Pfizer Inc.
04/26/21
-
155
Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
PROXIMAGEN, LLC
04/26/21
-
106
Morphinan derivatives for the treatment of neuropathic pain
Nektar Therapeutics
04/26/21
-
243
Piperidine derivatives as inhibitors of ubiquitin specific protease 7
ALMAC DISCOVERY LIMITED
04/26/21
-
19
Substituted benzamides and methods of use thereof
GENENTECH, INC.; XENON PHARMACEUTICALS INC.
04/26/21
-
33
Sulfonylcycloalkyl carboxamide compounds
Genentech, Inc.
04/26/21
-
43
Trk-inhibiting compound
ONO PHARMACEUTICAL CO., LTD.
04/26/21
-
96
Wee-1 inhibiting pyrazolopyrimidinone compounds
ALMAC DISCOVERY LIMITED
04/26/21
-
22
1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
NOVARTIS AG
04/25/21
-
432
2-(morpholin-4-yl)-1,7-naphthyridines
BAYER PHARMA AKTIENGESELLSCHAFT
04/25/21
-
39
2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
BLUEPRINT MEDICINES CORPORATION
04/25/21
-
1204
6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
SHIONOGI & CO., LTD.
04/25/21
-
123
Composition and methods for inhibiting mammalian sterile 20-like kinase 1
THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN
04/25/21
-
3
Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
PHARMAKEA, INC.
04/25/21
-
8
FXR (NR1H4) modulating compounds
Gilead Sciences, Inc.
04/25/21
-
106
Galactoside inhibitor of galectins
Galecto Biotech AB
04/25/21
-
352
HIV protease inhibitors
Gilead Sciences, Inc.
04/25/21
-
191
Heteroaryl compounds and uses thereof
Celgene CAR LLC; Sanofi
04/25/21
-
54
Indazole compounds and uses thereof
Incyte Corporation
04/25/21
-
24
Materials and method for inhibiting replication protein A and uses thereof
Indiana University Research and Technology Corporation
04/25/21
-
105
Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
ARRAY BIOPHARMA INC.
04/25/21
-
381
PD-1/PD-L1 inhibitors
Gilead Sciences, Inc.
04/25/21
-
71
Substituted piperazines as selective HDAC1,2 inhibitors
REGENACY PHARMACEUTICALS, INC.
04/25/21
-
343
ULK1 inhibitors and methods using same
SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY
04/25/21
-
43
Compounds that are ERK inhibitors
Merck Sharp & Dohme Corp.
04/19/21
-
20
Indazole containing macrocycles and therapeutic uses thereof
Samumed, LLC
04/19/21
-
220
Neprilysin inhibitors
Theravance Biopharma R&D IP, LLC
04/19/21
-
15
Thienopyrimidine derivative and use thereof in medicine
Sunshine Lake Pharma Co., Ltd.
04/19/21
-
106
2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors
Almirall, S.A.
04/18/21
-
77
2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
BAYER PHARMA AKTIENGESELLSCHAFT
04/18/21
-
33
Benzofuran derivative, preparation method thereof and use thereof in medicine
Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
04/18/21
-
138
CXCR4 inhibitors and uses thereof
X4 PHARMACEUTICALS, INC.
04/18/21
-
26
CaMKII inhibitors and uses thereof
The Johns Hopkins University
04/18/21
-
138
Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
Synchronicity Pharma, Inc.
04/18/21
-
20
Carboxamide derivatives useful as rsk inhibitors
PHOENIX MOLECULAR DESIGNS
04/18/21
-
32
Certain chemical entities, compositions, and methods
NEUPHARMA, INC.
04/18/21
-
46
Glucosylceramide synthase inhibitors for the treatment of diseases
TBA
04/18/21
-
24
Mammalian and bacterial nitric oxide synthase inhibitors
Northwestern University
04/18/21
-
2
Pharmaceutical uses of pyridine carboxamide derivatives
JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
04/18/21
-
232
Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors
Array BioPharma Inc.
04/18/21
-
7
Therapeutic compounds and uses thereof
Kala Pharmaceuticals, Inc.
04/18/21
-
8
1,3,5-triazine derivative and method of using same
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
04/13/21
-
66
6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
Samumed, LLC
04/13/21
-
6
Adenosine A3 receptor modulators
Palobiofarma, S.L.
04/13/21
-
19
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
04/13/21
-
190
Condensed lactam derivative
SUMITOMO DAINIPPON PHARMA CO., LTD.
04/13/21
-
57
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent GmbH
04/13/21
-
16
Indazole compounds and uses thereof
Incyte Corporation
04/13/21
-
2
Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
CTXT PTY LTD
04/13/21
-
18
Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents
ZENJI RESEARCH LABORATORIES
04/13/21
-
420
Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
Lycera Corporation; Merck Sharp & Dohme Corp.
04/13/21
-
96
Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
Board of Regents, The University of Texas System; ChemPartner Corporation
04/13/21
-
40
Neprilysin inhibitors
Theravance Biopharma R&D IP, LLC
04/12/21
-
5
PPARG modulators for the treatment of osteoporosis
The Scripps Research Institute; The University of Toledo
04/12/21
-
75
4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
Eastern Virginia Medical School; The Regents of the University of California Santa; The United States of America Department of Health; Thomas Jefferson University
04/11/21
-
6
6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds
Eli Lilly and Company
04/11/21
-
20
Aryldiazepine derivatives as RSV inhibitors
Enanta Pharmaceuticals, Inc.
04/11/21
-
46
Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
King''s College London
04/11/21
-
20
C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
Je II Pharmaceutical Co., Ltd.
04/11/21
-
15
Compounds and their use for reducing uric acid levels
Acquist LLC
04/11/21
-
27
Dopamine D2 receptor ligands
The Broad Institute, Inc.; Massachusetts Institute of Technology
04/11/21
-
62
Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
Xenon Pharmaceuticals Inc.
04/11/21
-
12
Heterocyclic compounds as FGFR inhibitors
Guangzhou Innocare Pharma Tech Co., Ltd.
04/11/21
-
25
Iso-citrate dehydrogenase (IDH) inhibitor
SHANGHAI METON PHARMACEUTICAL CO., LTD
04/11/21
-
38
Morphan and morphinan analogues, and methods of use
ALKERMES PHARMA IRELAND LIMITED
04/11/21
-
152
Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
JAPAN TOBACCO INC.
04/11/21
-
28
Signaling-biased mu opioid receptor agonists
THE SCRIPPS RESEARCH INSTITUTE
04/11/21
-
148
Spirocyclic containing compounds and pharmaceutical uses thereof
GB005, Inc.
04/11/21
-
14
Substituted aminopyrimidine compounds and methods of use
SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC
04/11/21
-
42
1,3-diaza-spiro-[3.4]-octane derivatives
GRÜNENTHAL GMBH
04/04/21
-
64
6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
Pfizer Inc.
04/04/21
-
97
Amide compounds as kinase inhibitors, compositions and methods of treatment
Translation Drug Development, LLC
04/04/21
-
33
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences, Inc.
04/04/21
-
96
Benzimidazole derivatives: preparation and pharmaceutical applications
MEI Pharma, Inc.
04/04/21
-
4
Bicyclic compounds as dual ATX/CA inhibitors
Hoffmann-La Roche Inc.
04/04/21
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte Corporation
04/04/21
-
29
Cyclic di-nucleotide compounds as STING agonists
Merck Sharp & Dohme Corp.
04/04/21
-
204
Imidazotriaines and imidazopyrimidines as kinase inhibitors
INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
04/04/21
-
11
Isoquinoline derivatives and use thereof
Purdue Pharma L.P.
04/04/21
-
37
Methods for treating depressive symptoms
ALKERMES PHARMA IRELAND LIMITED
04/04/21
-
508
Pyrazolopyrimidinone compounds and uses thereof
Aduro BioTech Inc.
04/04/21
-
158
Pyridone amides as modulators of sodium channels
VERTEX PHARMACEUTICALS INCORPORATED
04/04/21
-
35
Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
THE JOHNS HOPKINS UNIVERSITY
04/04/21
-
118
Tertiary alcohols as PI3K-γ inhibitors
Incyte Corporation
04/04/21
-
315
Triazole furan compounds as agonists of the APJ receptor
AMGEN INC.
04/04/21
-
242
Biphenyl compound or salt thereof
Taiho Pharmaceutical Co., Ltd.
03/30/21
-
5
1,1 ′-sulfanediyl-di-beta-D-galactopyranosides as inhibitors of galectins
GALECTO BIOTECH AB
03/28/21
-
380
Amido spirocyclic amide and sulfonamide derivatives
FORMA TM, LLC; Genentech, Inc.
03/28/21
-
230
Biaryl kinase inhibitors
Bristol-Myers Squibb Company
03/28/21
-
51
Cyanoindazole compounds and uses thereof
Incyte Corporation
03/28/21
-
4
Cyclodextrin-panobinostat adduct
MIDATECH LTD.
03/28/21
-
10
D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof
Peking University
03/28/21
-
204
Heterocyclic compounds and uses thereof
Incyte Corporation
03/28/21
-
6
Protease inhibitors
MEDIVIR AB
03/28/21
-
173
Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors
Bristol-Myers Squibb Company
03/28/21
-
34
2-aminoquinazoline derivatives as P70S6 kinase inhibitors
SENTINEL ONCOLOGY LIMITED
03/27/21
-
199
4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors
Array BioPharma Inc.; Celgene Corporation
03/27/21
-
841
4-Azaindole compounds
Bristol-Myers Squibb Company
03/27/21
-
95
Bicyclic heteroaryl substituted compounds
Bristol-Myers Squibb Company
03/27/21
-
140
Compounds and methods for the enhanced degradation of targeted proteins
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY
03/27/21
-
49
Compounds for modulating aquaporins
APOGLYX AB
03/27/21
-
2
Diaminopyrimidine benzenesulfone derivatives and uses thereof
Dana-Farber Cancer Institute, Inc.
03/27/21
-
28
Fused pyrimidine derivatives
HOFFMANN-LA ROCHE, INC.
03/27/21
-
72
Indole derivatives and use thereof
Purdue Pharma L.P.
03/27/21
-
296
Inhibitors of plasma kallikrein and uses thereof
Shire Human Genetic Therapies, Inc.
03/27/21
-
31
Substituted imidazo[1,2-A]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof
JN Therapeutics
03/27/21
-
63
5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
BAYER PHARMA AKTIENGESELLSCHAFT
03/21/21
-
130
Aliphatic prolinamide derivatives
ORION OPHTHALMOLOGY LLC
03/21/21
-
12
Alkynyl dihydroquinoline sulfonamide compounds
AMGEN INC.
03/21/21
-
29
Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof
The Research Foundation for the State University of New York; New York University
03/21/21
-
12
Benzimidazole derivatives as EP4 ligands
BAYER PHARMA AKTIENGESELLSCHAFT
03/21/21
-
51
Benzo[b]thiophene compounds as STING agonists
Merck Sharp & Dohme Corp.
03/21/21
-
427
Bridged bicyclic compounds as farnesoid X receptor modulators
Bristol-Myers Squibb Company
03/21/21
-
6
Catecholamine prodrugs for use in the treatment of Parkinson's disease
H. Lundbeck A/S
03/21/21
-
86
Chemical compounds
ASTRAZENECA AB
03/21/21
-
17
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
XW LABORATORIES INC.
03/21/21
-
115
Cyclopropylamines as LSD1 inhibitors
Incyte Corporation
03/21/21
-
116
Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
Pharmaxis Ltd.
03/21/21
-
44
Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof
Pharmaxis Ltd.
03/21/21
-
17
Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
University Health Network
03/21/21
-
68
Ketone inhibitors of lysine gingipain
CORTEXYME, INC.
03/21/21
-
31
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb Company
03/21/21
-
106
Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
Boehringer Ingelheim International GmbH
03/21/21
-
29
Pyrimidinone and its derivatives inhibiting factor XIa
ONO PHARMACEUTICAL CO., LTD.
03/21/21
-
137
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
Boehringer Ingelheim International GmbH
03/21/21
-
9
Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
Wisconsin Alumni Research Foundation
03/21/21
-
25
Tetrahydronaphthalene derivative
ONO PHARMACEUTICAL CO., LTD.
03/21/21
-
207
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals, Inc.
03/21/21
-
59
Treatment of infectious diseases with glucose uptake inhibitors
KADMON CORPORATION, LLC
03/21/21
-
87
MALT1 inhibitors and uses thereof
Cornell University; Dana-Farber Cancer Institute, Inc.; Children''s Medical Center Corporation
03/15/21
-
28
Selective Bruton's tyrosine kinase inhibitor and use thereof
HANGZHOU HERTZ PHARMACEUTICAL CO., LTD.
03/15/21
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics Incorporated
03/15/21
-
783
Tricyclic sulfones as RORγ modulators
Bristol-Myers Squibb Company
03/15/21
-
16
Agent for treating synucleinopathy
Tohoku University; National University Corporation Okayama University
03/14/21
-
88
Aminopyridine derivatives and their use as selective ALK-2 inhibitors
Novartis AG
03/14/21
-
1072
Biaryl amide compounds as kinase inhibitors
NOVARTIS AG
03/14/21
-
2
Compounds as rearranged during transfection (RET) inhibitors
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
03/14/21
-
28
Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
Metabasis Therapeutics, Inc.
03/14/21
-
150
Oxadiazole transient receptor potential channel inhibitors
Genentech, Inc.
03/14/21
-
275
Oxadiazole transient receptor potential channel inhibitors
Genentech, Inc.
03/14/21
-
656
PD-1/PD-L1 inhibitors
Gilead Sciences, Inc.
03/14/21
-
294
Pyrimidine derivative
ASKA PHARMACEUTICAL CO., LTD.
03/14/21
-
59
STK4 inhibitors for treatment of hematologic malignancies
DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE
03/14/21
-
10
Substituted bicyclic compounds
Bristol-Myers Squibb Company
03/14/21
-
203
Substituted carbonucleoside derivatives useful as anticancer agents
Pfizer Inc.
03/14/21
-
17
3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA
NOVARTIS AG
03/11/21
-
43
5-hydroxytryptamine receptor 7 activity modulators and their method of use
Temple University Of The Commonwealth System of Higher Education
03/11/21
-
11
Antidiabetic bicyclic compounds
Merch Sharp & Dohne Corp. Rahway
03/11/21
-
58
Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
Washington University
03/11/21
-
129
Cyclopropylamines as LSD1 inhibitors
Incyte Corporation
03/11/21
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94
GLP-1 receptor agonists and uses thereof
Pfizer Inc.
03/11/21
-
118
Imidazolepyridine compounds and uses thereof
Novartis AG
03/11/21
-
34
Inhibitors of lysine gingipain
CORTEXYME, INC.
03/11/21
-
182
Kappa opioid receptor antagonists and products and methods related thereto
BLACKTHORN THERAPEUTICS, INC.; THE SCRIPPS RESEARCH INSTITUTE
03/11/21
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53
Macrocyclic MCL-1 inhibitors and methods of use
AbbVie Inc.
03/11/21
-
3
Quinazolines as potassium ion channel inhibitors
Bristol-Myers Squibb Company
03/11/21
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14
Small-molecule HSP90 inhibitors
Sloan-Kettering Institute for Cancer Research
03/11/21
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190
Bicyclic quinazolinone derivatives
Hoffmann-La Roche Inc.
03/10/21
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178
Carbazole derivatives
Bristol-Myers Squibb Company
03/10/21
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109
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals, Inc.
03/10/21
-
196
Indole derivatives and their use in neurodegenerative diseases
Merck Patent GmbH
03/10/21
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10
KCNQ2-5 channel activator
Ono Pharmaceutical Co., Ltd.
03/10/21
-
127
Phenylpyrrolidinone formyl peptide 2 receptor agonists
Bristol-Myers Squibb Company
03/10/21
-
169
Somatostatin receptor subtype 4 (SSTR4) agonists
Centrexion Therapeutics Corporation
03/10/21
-
37
Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
Incyte Corporation
03/10/21
-
7
Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof
Leo Pharma A/S
03/08/21
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16
Covalent inhibitors of PAD4
Padlock Therapeutics, Inc.
03/08/21
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21
Degradation of tripartite motif-containing protein 24 (TRIM24) by conjugation of TRIM24 inhibitors with E3 ligase ligand and methods of use
DANA-FARBER CANCER INSTITUTE, INC.
03/08/21
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445
MCL-1 inhibitors
Gilead Sciences, Inc.
03/08/21
-
15
MU opioid receptor modulators
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NÜRNBERG; THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
03/08/21
-
289
P2X7 modulators
Janssen Pharmaceutica NV
03/08/21
-
1
Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GALAPAGOS NV
03/08/21
-
14
Substituted benzimidazoles, their preparation and their use as pharmaceuticals
Neomed Institute
03/08/21
-
337
Substituted purine derivative
SUMITOMO DAINIPPON PHARMA CO., LTD.
03/08/21
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308
Amido-benzyl sulfone and sulfoxide derivates
TBA
03/02/21
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152
Amino acid compounds and methods of use
Pliant Therapeutics, Inc.
03/02/21
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44
CDK inhibitors
G1 Therapeutics, Inc.
03/02/21
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69
Compounds
Exonate Limited
03/02/21
-
43
Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
03/02/21
-
57
Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International GmbH
03/02/21
-
64
Kinase inhibitor, and preparing method and pharmaceutical use thereof
GAN & LEE PHARMACEUTICALS
03/02/21
-
23
Mutant IDH1 inhibitors
Eli Lilly and Company
03/02/21
-
388
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
Incyte Holdings Corporation; Incyte Corporation
03/02/21
-
40
Pyrimidine derivative and use thereof
HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC.
03/02/21
-
36
Rho kinase inhibitors
Kadmon Corporation, LLC
03/02/21
-
23
Somatostatin modulators and uses thereof
CRINETICS PHARMACEUTICALS, INC.
03/02/21
-
125
Therapeutic compounds and uses thereof
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
03/02/21
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149
1,2-substituted cyclopentanes as orexin receptor antagonists
TAKEDA PHARMACEUTICAL COMPANY LIMITED
02/22/21
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269
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics Limited
02/22/21
-
25
C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme Corp.
02/22/21
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71
FGFR3 fusion gene and pharmaceutical drug targeting same
Chugai Seiyaku Kabushiki Kaisha
02/22/21
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246
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
02/22/21
-
13
Macrocylic compounds as ROS1 kinase inhibitors
Array BioPharma Inc.
02/22/21
-
647
Methods, compositions, and uses of novel Fyn kinase inhibitors
TBA
02/22/21
-
43
N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof
NORTHEASTERN UNIVERSITY
02/22/21
-
89
OXA-Diazaspiro compounds having activity against pain
ESTEVE PHARMACEUTICALS, S.A.
02/22/21
-
64
Piperazine-substituted benzothiophenes for treatment of mental disorders
Otsuka Pharmaceutical Co., Ltd.
02/22/21
-
15
Prodrug amino acid derivative
TAISHO PHARMACEUTICAL CO., LTD.
02/22/21
-
69
Pyrrolidine derivatives
Hoffmann-La Roche Inc.
02/22/21
-
124
Quinoxaline compounds as type III receptor tyrosine kinase inhibitors
Development Center for Biotechnology
02/22/21
-
23
Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections
Gilead Sciences, Inc.
02/22/21
-
127
Substituted indazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme Corp.
02/22/21
-
39
Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
Stingray Therapeutics, Inc.; The University of Utah
02/22/21
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206
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals, Inc.
02/22/21
-
233
Triazole pyridyl compounds as agonists of the APJ receptor
AMGEN INC.
02/22/21
-
18
Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer
JUBILANT BIOSYS LIMITED
02/22/21
-
14
Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
JUBILANT BIOSYS LIMITED
02/22/21
-
242
5-substituted indazole-3-carboxamides and preparation and use thereof
Samumed, LLC
02/21/21
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115
Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
1ST Biotherapeutics, Inc.
02/21/21
-
306
Bicyclic derivatives
Hoffmann-La Roche Inc.
02/21/21
-
104
Boronic acid derivatives
MERCK PATENT GMBH
02/21/21
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides dipeptidyl peptidase 1 inhibitors
ASTRAZENECA AB
02/21/21
-
43
Condensed [1,4] diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffmann-La Roche Inc.
02/21/21
-
48
Fused pyrimidine derivatives
HOFFMANN-LA ROCHE INC.
02/21/21
-
30
Heterocyclic compounds as immunomodulators
Incyte Corporation
02/21/21
-
104
Imidazopyridazine compounds
Pfizer Inc.
02/21/21
-
10
Isoxazole carboxamides as irreversible SMYD inhibitors
EPIZYME, INC.
02/21/21
-
4
LXR agonists and uses thereof
Rgenix, Inc.
02/21/21
-
72
Pyridyl benzothiophenes as kinase inhibitors
ALLERGAN, INC.
02/21/21
-
39
Substituted N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and N-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives P2X7 receptor antagonists
Axxam S.P.A.
02/21/21
-
36
Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
Peking University
02/21/21
-
67
5-5 fused rings as C5a inhibitors
ChemoCentryx, Inc.
02/16/21
-
29
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Ogeda SA
02/16/21
-
3
Heterocyclic compounds for the treatment of disease
OPPILAN PHARMA LTD.
02/16/21
-
80
Tricyclic compounds as anticancer agents
Bristol-Myers Squibb Company
02/16/21
-
42
Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.
02/16/21
-
100
(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
BAYER PHARMA AKTIENGESELLSCHAFT
02/15/21
-
17
(S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using
Iowa State University Research Foundation, Inc.
02/15/21
-
68
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
02/15/21
-
23
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
02/15/21
-
100
Compound having mutant IDH inhibitory activity, preparation method and use thereof
SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
02/15/21
-
9
Curcumin analogues as zinc chelators and their uses
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
02/15/21
-
147
Cyanopyrrolidines as dub inhibitors for the treatment of cancer
MISSION THERAPEUTICS LIMITED
02/15/21
-
62
Glucocorticoid receptor agonist and immunoconjugates thereof
AbbVie Inc.
02/15/21
-
45
Heterocyclic derivatives and their use in the treatment of neurological disorders
Novartis AG
02/15/21
-
55
Indole derivatives and their use as protein kinase inhibitors
RESPIVERT LIMITED
02/15/21
-
56
Modulators of calcium release-activated calcium channel
RHIZEN PHARMACEUTICALS SA
02/15/21
-
4
Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
ARENA PHARMACEUTICALS, INC.
02/15/21
-
135
Pyridine sulfonamides
AMGEN INC.
02/15/21
-
21
Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
Yeda Research and Development Co. Ltd.
02/15/21
-
68
Tetrahydronaphthyl urea derivative
MOCHIDA PHARMACEUTICAL CO., LTD.
02/15/21
-
841
Pyridyl substituted indole compounds
Bristol-Myers Squibb Company
02/08/21
-
60
ABHD6 and dual ABHD6/MGL inhibitors and their uses
MAKSCIENTIFIC, LLC
02/07/21
-
89
Amino compounds for treatment of medical disorders
Achillion Pharmaceuticals, Inc.
02/07/21
-
83
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals Inc.
02/07/21
-
27
Benzimidazole derivatives as PI3 kinase inhibitors
GLAXOSMITHKLINE LLC
02/07/21
-
124
Bruton's tyrosine kinase inhibitors
Zibo Biopolar Changsheng Pharmaceutical Co. Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
02/07/21
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90
Guanidine derivative and medical use thereof
Toray Industries, Inc.
02/07/21
-
78
PDE4 inhibitor
SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
02/07/21
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137
Substituted pyrimidines as cyclin-dependent kinase inhibitors
SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
02/07/21
-
90
ASK1 isoindolin-1-one inhibitors and methods of use thereof
Hepatikos Therapeutics, LLC
02/01/21
-
7
Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffman-La Roche Inc.
02/01/21
-
69
Compounds and methods for inhibiting JAK
Dizal (Jiangsu) Pharmaceutical Co., Ltd.
02/01/21
-
17
Method for preparing pyrrolo[3,2-D]pyrimidine compound, and intermediates thereof
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
02/01/21
-
73
Protein kinase B inhibitors
AstraZeneca AB
02/01/21
-
10
Pyrimidine derivative, method for preparing same and use thereof in medicine
Zhejiang Hisun Pharmaceutical Co., Ltd.
02/01/21
-
21
Selective estrogen receptor degraders
Eli Lilly and Company
02/01/21
-
145
Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
MISSION THERAPEUTICS LIMITED
02/01/21
-
31
Tricyclic rho kinase inhibitors
Bristol-Myers Squibb Company
02/01/21
-
143
6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed, LLC
01/31/21
-
14
Antiproliferative pyrimidine-based compounds
G1 Therapeutics, Inc.
01/31/21
-
127
Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity
KANCERA AB
01/31/21
-
52
Substituted quinazolines for inhibiting kinase activity
NEUPHARMA, INC.
01/31/21
-
33
Biaryl urea derivative or salt thereof and preparation process and use for the same
Fudan University
01/25/21
-
5
Bicyclic compounds as dual ATX/CA inhibitors
Hoffmann-La Roche Inc.
01/25/21
-
14
Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies
GALDERMA RESEARCH & DEVELOPMENT
01/25/21
-
40
Diphenylaminopyrimidine and triazine compound, and pharmaceutical composition and use thereof
ARROMAX PHARMATECH CO., LTD.
01/25/21
-
14
EZH2 inhibitor and use thereof
TARAPEUTICS SCIENCE INC.
01/25/21
-
3
Heterocyclic degronimers for target protein degradation
C4 Therapeutics, Inc.
01/25/21
-
342
Heterocyclylamines as PI3K inhibitors
Incyte Corporation; Incyte Holdings Corporation
01/25/21
-
333
Pyrimido-pyridazinone compounds and methods of use thereof
Asan BioSciences, LLC
01/25/21
-
47
Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
Merck Sharp & Dohme Corp.
01/25/21
-
50
Substituted pyrimidines for preventing or treating cancer and inflammatory diseases
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
01/25/21
-
601
TYK2 inhibitors and uses thereof
Nimbus Lakshmi, Inc.
01/25/21
-
46
Tetrahydroisoquinoline derived PRMT5-inhibitors
CTXT PTY. LTD
01/25/21
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172
Alkoxy compounds for disease treatment
ACUCELA INC.
01/18/21
-
68
Compounds
MISSION THERAPEUTICS LIMITED
01/18/21
-
19
Epoxyketone compounds for enzyme inhibition
CENTRAX INTERNATIONAL, INC.
01/18/21
-
85
Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International GmbH
01/18/21
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615
Heterocycle derivatives having TrkA inhibitory activity
Shionogi & Co., Ltd.
01/18/21
-
158
Imidazopyridines and imidazopyrazines as LSD1 inhibitors
Incyte Corporation
01/18/21
-
312
Immunomodulator compounds
ChemoCentryx, Inc.
01/18/21
-
20
Inhibitors of bruton's tyrosine kinase
HOFFMANN-LA ROCHE INC.
01/18/21
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205
Therapeutically active compositions and their methods of use
Agios Pharmaceuticals, Inc.
01/18/21
-
113
Diazaspirocycloalkane and azaspirocycloalkane
Hoffmann-La Roche Inc.
01/12/21
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168
Bicyclic heterocycles as FGFR4 inhibitors
Incyte Corporation
01/10/21
-
130
Bromodomain inhibitors
AbbVie Inc.
01/10/21
-
1023
CARM1 inhibitors and uses thereof
Epizyme, Inc.
01/10/21
-
115
Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases
University of Washington
01/10/21
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248
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
01/10/21
-
130
Melanocortin receptor-specific peptides
Palatin Technologies, Inc.
01/10/21
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16
Methods to treat lymphoplasmacytic lymphoma
Dana-Farber Cancer Institute, Inc.
01/10/21
-
107
Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
Jinagsu Hengrui Medicine Co., Ltd; Shanghai Hengrui Pharmaceutical Co., Ltd.
01/10/21
-
14
Pyrazolopyrimidone derivatives and methods of use thereof
Shanghai Hengrui Pharmaceutical Co., ltd.; Jiangsu Hangrui Medicine Co., Ltd.
01/10/21
-
72
Pyridyl benzothiophenes as kinase inhibitors
Allergan, Inc.
01/10/21
-
150
6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed, LLC
12/21/20
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19
C5-C6-oxacyclic fused iminothiadiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme Corp.
12/21/20
-
240
Compounds, compositions and methods
Denali Therapeutics Inc.
12/21/20
-
11
Enhancer of zeste homolog 2 inhibitors
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
12/21/20
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54
Substituted cyclopropanes as PDE-10 inhibitors
Sunovion Pharamaceuticals Inc.
12/21/20
-
11
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
CrystalGenomics, Inc.
12/20/20
-
12
2-amino-6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck A/S
12/20/20
-
20
3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2, 7-dione compounds for the treatment and prophylaxis of virus infection
Hoffmann-La Roche Inc.
12/20/20
-
27
5-aromatic alkynyl substituted benzamide compound and preparation method, pharmaceutical composition, and use thereof
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
12/20/20
-
43
6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
University of Pittsburgh—Of the Commonwealth System of Higher Education
12/20/20
-
65
Arginase inhibitors as therapeutics
Mars, Incorporated
12/20/20
-
17
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
XW LABORATORIES INC.
12/20/20
-
171
Compounds for the treatment of pain
Alkermes, Inc.
12/20/20
-
3
Compounds useful for inhibiting ROR-gamma-t
Eli Lilly and Company
12/20/20
-
1
Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
Suzhou Zelgen Biopharmaceuticals Co., Ltd.
12/20/20
-
18
Diaryl macrocycles as modulators of protein kinases
Turning Point Therapeutics, Inc.
12/20/20
-
262
Heteroaryl substituted aminopyridine compounds
Bristol-Myers Squibb Company
12/20/20
-
68
Heterocyclic compounds as immunomodulators
Incyte Corporation
12/20/20
-
222
Indole carboxamide compounds
Bristol-Myers Squibb Company
12/20/20
-
37
Macrocycles as PDE1 inhibitors
H. Lundbeck A/S
12/20/20
-
161
Spiroindolinones as DDR1 inhibitors
Hoffmann-La Roche Inc.
12/20/20
-
111
Substituted 5-cyanoindole compounds and uses thereof
Novartis AG
12/20/20
-
249
Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
Celgene CAR LLC; Sanofi
12/20/20
-
29
Tricyclic heterocycles as BET protein inhibitors
Incyte Corporation
12/20/20
-
35
Bicyclic proline compounds
Genentech, Inc.
12/14/20
-
8
Methods to treat lymphoplasmacytic lymphoma
Dana-Farber Cancer Institute, Inc.
12/14/20
-
39
Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
12/14/20
-
15
Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals, Inc.
12/14/20
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259
2,4-disubstituted pyrimidines useful as kinase inhibitors
Celgene CAR LLC
12/13/20
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325
Aryl ethers and uses thereof
Peloton Therapeutics, Inc.
12/13/20
-
76
Aza-heteroaryl compounds as PI3K-gamma inhibitors
Incyte Corporation
12/13/20
-
8
Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
Jenrin Discovery, LLC
12/13/20
-
42
Compounds for cancer chemotherapeutic sensitization
REGENTS OF THE UNIVERSITY OF MINNESOTA; THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
12/13/20
-
191
Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
12/13/20
-
5
Methods and compositions for cell-proliferation-related disorders
Agios Pharmaceuticals, Inc.
12/13/20
-
4
Pyrrolopyrimidine comprising cyclopentyl substituent
CENTAURUS BIOPHARMA CO.; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
12/13/20
-
258
Somatostatin modulators and uses thereof
CRINETICS PHARMACEUTICALS, INC.
12/13/20
-
594
Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GluN2B receptor modulators
JANSSEN PHARMACEUTICA NV
12/13/20
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397
Therapeutic compounds
CELGENE QUANTICEL RESEARCH, INC.
12/13/20
-
26
Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
The USA, as represented by the Secretary, Department of Health and Human Services; SRI International
12/13/20
-
6
Certain chemical entities, compositions, and methods
NeuPharma, Inc.
12/08/20
-
56
1,3-dihydroxy-phenyl derivatives useful as immunomodulators
Bristol-Meyers Squibb Company
12/07/20
-
18
1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L.
12/07/20
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212
Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
Janssen Pharmaceutica NV
12/07/20
-
14
Cardiac glycoside analogs and their use in methods for inhibition of viral infection
The John Hopkins University
12/07/20
-
63
Chemical compounds
AstraZeneca AB
12/07/20
-
161
Compounds, compositions, and methods
Denali Therapautics Inc.
12/07/20
-
26
Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
12/07/20
-
29
Cyanopyrrolidine derivatives as inhibitors for DUBs
MISSION THERAPEUTICS LIMITED
12/07/20
-
15
Dopamine D1 receptor positive allosteric modulators
Eli Lilly and Company
12/07/20
-
24
Heterocyclic compounds used as FGFR inhibitors
Nanjing InnoCare Pharma Tech Co., Ltd.
12/07/20
-
114
Histone demethylase inhibitors
Celgene Quanticel Research, Inc.
12/07/20
-
69
Imidazopyridazine compounds and their use
HUTCHISON MEDIPHARMA LIMITED
12/07/20
-
97
Isoindoline compositions and methods for treating neurodegenerative disease
COGNITION THERAPEUTICS, INC.
12/07/20
-
60
Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Array BioPharma Inc.
12/07/20
-
95
Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
Loxo Oncology Inc.
12/07/20
-
159
Selective estrogen receptor down-regulators
AstraZeneca AB
12/07/20
-
7
TRPV4 antagonists
GlaxoSmithKline Intellectual Property Development Limited
12/07/20
-
438
Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions
ESTEVE PHARMACEUTICALS, S.A.
12/07/20
-
16
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics Corporation
11/30/20
-
53
1,4-dicarbonyl-piperidyl derivatives
Merck Patent GmbH
11/30/20
-
22
Compounds and compositions as protein kinase inhibitors
Array BioPharma Inc.
11/30/20
-
149
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences, Inc.
11/30/20
-
8
Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
11/30/20
-
40
Isoquinolones as BTK inhibitors
Boehringer Ingelheim International GmbH
11/30/20
-
51
Pharmacokinetically improved compounds
SURFACE LOGIX, LLC
11/30/20
-
42
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics Incorporated
11/30/20
-
7
Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
Marquette University; Concordia University Inc.
11/30/20
-
114
Substituted dihydroisoquinolinone compounds
Pfizer Inc.
11/30/20
-
42
Substituted imidazo[1,2-a]pyridines as PDE-10 inhibitors
SUNOVION PHARMACEUTICALS INC.
11/30/20
-
7
Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
11/30/20
-
138
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme Corp.
11/30/20
-
13
Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
vTv Therapeutics LLC
11/30/20
-
11
3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman) Limited
11/29/20
-
22
4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
Heptares Therapeutics Limited
11/29/20
-
61
A3 adenosine receptor agonists
The United States of America, as represented by the Secretary, Department of Health and Human Services; Saint Louis University
11/29/20
-
58
Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease
National Health Research Institutes; Academia Sinica
11/29/20
-
356
Bruton's tyrosine kinase inhibitors
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.
11/29/20
-
18
Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.
11/29/20
-
10
Heteroaryl substituted benzoic acids as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme Corp.
11/29/20
-
51
Heterocyclic sulfonamide derivative and medicine containing same
EA Pharma Co., Ltd.
11/29/20
-
8
Indane-amines as PD-L1 antagonists
ChemoCentryx, Inc.
11/29/20
-
12
Ingenol analogs, pharmaceutical compositions and methods of use thereof
GlaxoSmithKline Intellectual Property Development Limited
11/29/20
-
41
Inhibitors of RET
BLUEPRINT MEDICINES CORPORATION
11/29/20
-
37
Macrocyclic inhibitors of myeloperoxidase
Bristol-Myers Squibb Company
11/29/20
-
12
Quinolone-3-diarylethers
Oregon Health & Science University
11/29/20
-
12
SHMT inhibitors
The Trustees of Princeton University
11/29/20
-
211
Small molecule agonists of neurotensin receptor 1
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
11/29/20
-
174
Substituted 3,6-diazabicyclo[3.2.0]heptanes
INDIVIOR UK LIMITED
11/29/20
-
1143
TYK2 inhibitors and uses thereof
Nimbus Lakshimi, Inc.
11/29/20
-
56
Triazole DAGLα inhibitors
THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY
11/29/20
-
69
Use of physiological cooling active ingredients, and agents containing such active ingredients
SYMRISE AG; BASF SE
11/29/20
-
73
4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
Takeda Pharmaceutical Company Limited
11/22/20
-
22
Benzimidazoles derivatives as Tec kinases family inhibitors
GB005, INC.
11/22/20
-
15
Cancer therapeutics
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
11/22/20
-
14
Carboxylic acid compounds
Sumitomo Dainippon Pharma Co., Ltd.
11/22/20
-
63
Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-HT1A receptors
NEUROLIXIS; UNIVERSITE JAGELLONE
11/22/20
-
1
Crystalline FGFR4 inhibitor compound and uses thereof
Eisai R&D Management Co., LTD.
11/22/20
-
222
Cycloalkylamines as monoamine reuptake inhibitors
SUNOVION PHARAMCEUTICALS INC.
11/22/20
-
14
HYPDH inhibitors and methods of use for the treatment of kidney stones
Wake Forest University Health Sciences; UAB Research Foundation
11/22/20
-
100
Human plasma kallikrein inhibitors
BioCryst Pharmaceuticals, Inc.
11/22/20
-
164
IRAK4 inhibitor and use thereof
Beijing Hanmi Pharmaceutical Co., Ltd.
11/22/20
-
57
Indazole compounds as FGFR kinase inhibitor, preparation and use thereof
Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
11/22/20
-
9
Nitrogen-containing tricyclic compounds and uses thereof in medicine
NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
11/22/20
-
5
Organic compounds
INTRA-CELLULAR THERAPIES, INC.
11/22/20
-
41
Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions
Takeda Pharmaceutical Company Limited
11/22/20
-
16
Prolyl hydroxylase inhibitors
AERPIO THERAPEUTICS, INC.
11/22/20
-
23
Pyrrolopyrimidine compound
Centaurus Biophrama Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.
11/22/20
-
427
Quinazolinones as PARP14 inhibitors
Ribon Therapeutics Inc.
11/22/20
-
27
SHP2 inhibitors and uses thereof
SYNBLia Therapeutics, Inc.
11/22/20
-
206
Substituted quinoxalines as PDE-10 inhibitors
Sunovion Pharmaceuticals, Inc.
11/22/20
-
177
Triazolones and tetrazolones as inhibitors of ROCK
Bristol-Myers Squibb Company
11/22/20
-
508
IRAK4 inhibiting agents
BIOGEN MA INC.
11/21/20
-
11
2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
Genentech, Inc.
11/20/20
-
27
5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
ViiV HEALTHCARE UK (NO.5) LIMITED
11/20/20
-
153
Arylamide derivatives having multimodal activity against pain
ESTEVE PHARMACEUTICALS, S.A.
11/20/20
-
6
Bis-pyridazine compounds and their use in treating cancer
Cancer Research Technology Limited
11/20/20
-
37
Cot modulators and methods of use thereof
Gilead Sciences, Inc.
11/20/20
-
33
Dopamine D3 receptor antagonists having a morpholine moiety
INDIVIOR UK LIMITED
11/20/20
-
43
Ether compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals, Inc.
11/20/20
-
58
Fused tricyclic compounds as Raf kinase inhibitors
BEIGENE, LTD.
11/20/20
-
159
Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators
NOVARTIS AG
11/20/20
-
20
Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
Boehringer Ingelheim International GmbH
11/20/20
-
24
JAK inhibitors containing a 4-membered heterocyclic amide
Theravance Biopharma R&D IP, LLC
11/20/20
-
21
Kinase inhibitors and their use in cancer therapy
TECHNISCHE UNIVERSITÄT DORTMUND
11/20/20
-
28
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
Saint Louis University
11/20/20
-
87
Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
Boehringer Ingelheim International GmbH
11/20/20
-
221
NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
Ogeda SA
11/20/20
-
5
Prodrugs of imidazotriazine compounds as CK2 inhibitors
Bristol-Myers Squibb Company
11/20/20
-
803
Pyridazinones as PARP7 inhibitors
Ribon Therapeutics Inc.
11/20/20
-
36
Sodium channel modulators
The Florey Institute; The University of Melbourne
11/20/20
-
107
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
Boehringer Ingelheim International GmbH
11/20/20
-
980
Substituted piperidine compounds
EPIZYME, INC.
11/20/20
-
3
Tetrahydroisoquinolines as PRMT5 inhibitors
CTXT PTY LTD
11/20/20
-
9
Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics
GALDERMA RESEARCH & DEVELOPMENT
11/13/20
-
122
Glycosidase inhibitors
Asceneuron SA
11/13/20
-
302
Isoquinolin-3-YL carboxamides and preparation and use thereof
Samumed, LLC
11/13/20
-
37
Piperazinyl methanone NAAA inhibitors
The Regents of the University of California; Fondazione Istituto Italiano di Technologia
11/13/20
-
119
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
Incyte Corporation
11/13/20
-
100