Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Cmpds
    HGNC*
    Patent Title
    Organization
    Deposition
    Downloads
  2. 304
    Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors
    1St Biotherapeutics
    01/24/24
  3. 15
    1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use
    Modern Biosciences
    01/23/24
  4. 16
    Anti-cancer nuclear hormone receptor-targeting compounds
    Nuvation Bio
    01/23/24
  5. 101
    Beta-lactam derivatives for the treatment of diseases
    Insilico Medicine Ip
    01/23/24
  6. 119
    Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase
    Agency For Science, Technology And Research
    01/23/24
  7. 23
    Heterocyclic compounds as pad inhibitors
    Jubilant Epipad
    01/23/24
  8. 1
    SSTR4 agonist salts
    Eli Lilly
    01/23/24
  9. 23
    Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof
    Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
    01/23/24
  10. 483
    Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
    Array Biopharma
    01/23/24
  11. 152
    COMPOUNDS FOR INHIBITING KIF18A
    Volastra Therapeutics
    01/19/24
  12. 2
    CSF1R KINASE INHIBITOR AND USE THEREOF
    Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
    01/19/24
  13. 57
    FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2
    Enliven Therapeutics
    01/19/24
  14. 30
    GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF
    Deciphera Pharmaceuticals
    01/19/24
  15. 316
    HDAC6 INHIBITORS FOR TREATMENT OF METABOLIC DISEASE AND HFPEF
    Tenaya Therapeutics
    01/19/24
  16. 6
    HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Hutchison Medipharma
    01/19/24
  17. 45
    MEK INHIBITORS AND USES THEREOF
    Ikena Oncology
    01/19/24
  18. 31
    N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Shenzhen Edk Pharmaceutical Technology Co.
    01/19/24
  19. 4
    OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
    The Trustees Of Columbia University In The City Of New York
    01/19/24
  20. 78
    PYRAZOLEAMIDE DERIVATIVES
    Hoffmann-La Roche
    01/19/24
  21. 7
    Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
    Eli Lilly
    01/19/24
  22. 390
    SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF
    The Johns Hopkins University
    01/19/24
  23. 16
    Anti-cancer nuclear hormone receptor-targeting compounds
    Nuvation Bio
    01/17/24
  24. 6
    Conduritol aziridine derivatives and uses thereof
    University Of Saskatchewan
    01/17/24
  25. 43
    Pyrazine derivative and application thereof in inhibiting SHP2
    Suzhou Genhouse Pharmaceutical Co.
    01/17/24
  26. 39
    MACROCYCLIC PEPTIDE BORONATE IMMUNOMODULATORS
    Bristol-Myers Squibb
    01/16/24
  27. 212
    5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
    Origiant Pharmaceutical Co.
    01/12/24
  28. 13
    BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Shenzhen Chipscreen Biosciences Co.
    01/12/24
  29. 49
    FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28
    Dana-Farber Cancer Institute
    01/12/24
  30. 84
    HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
    SchrÖDinger
    01/12/24
  31. 64
    INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF
    Haisco Pharmaceuticals
    01/12/24
  32. 23
    N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
    Pliant Therapeutics
    01/12/24
  33. 135
    PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER
    The United States Of America,As Represented By The Secretary,Department Of Health And Human Services
    01/12/24
  34. 38
    SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
    The Broad Institute
    01/12/24
  35. 20
    TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF
    Medshine Discovery
    01/12/24
  36. 79
    BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
    The Florida International University Board Of Trustees
    01/11/24
  37. 154
    COMPOUND AS BRAIN-PERMEABLE BTK OR HER2 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Chengdu Hyperway Pharmaceuticals Co.
    01/11/24
  38. 271
    POLO LIKE KINASE 4 INHIBITORS
    Oric Pharmaceuticals
    01/11/24
  39. 88
    QUINAZOLINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
    The Asean Foundation
    01/11/24
  40. 47
    TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    The Research Foundation For The State University Of New York
    01/11/24
  41. 22
    Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors
    Forma Therapeutics
    01/08/24
  42. 784
    Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof
    Maze Therapeutics
    01/08/24
  43. 92
    Inhibtors of Raf kinases
    Kinnate Biopharma
    01/08/24
  44. 54
    Macrocyclic compounds for the treatment of medical disorders
    Achillion Pharmaceuticals
    01/08/24
  45. 8
    Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
    Ferris State University
    01/08/24
  46. 6
    1H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS AND APPLICATION THEREOF
    Medshine Discovery
    01/04/24
  47. 192
    AGONISTS OF STIMULATOR OF INTERFERON GENES STING
    The Scripps Research Institute
    01/04/24
  48. 64
    MACROCYCLIC COMPOUND
    Asahi Kasei Pharma
    01/04/24
  49. 169
    NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
    Les Laboratoires Servier
    01/04/24
  50. 10
    PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF
    Shanghai Longwood Biopharmaceuticals Co.
    01/04/24
  51. 69
    PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS
    Bayer Aktiengesellschaft
    01/04/24
  52. 12
    PYRROLOPYRIMIDINE COMPOUND AS BTK INHIBITOR AND USE THEREOF
    Medshine Discovery
    01/04/24
  53. 42
    SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS
    Artizan Biosciences
    01/04/24
  54. 334
    4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19)
    Almac Discovery
    12/29/23
  55. 57
    Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2
    Enliven Therapeutics
    12/29/23
  56. 12
    Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
    Haisco Pharmaceuticals
    12/29/23
  57. 31
    Prevention and/or treatment of CNS disorders
    Ildong Pharmaceutical Co.
    12/29/23
  58. 1
    Site specific homogeneous with KSP inhibitors
    Bayer Pharma Aktiengesellschaft
    12/29/23
  59. 13
    Substituted pyrimidinones as agonists of the APJ receptor
    Amgen
    12/29/23
  60. 44
    Sulfonamide derivatives for protein degradation
    Dana-Farber Cancer Institute
    12/29/23
  61. 100
    INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
    Abbvie
    12/25/23
  62. 127
    NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF
    Txinno Bioscience
    12/25/23
  63. 8
    Toll-like receptor ligands
    Inimmune
    12/24/23
  64. 46
    2-AMINOPYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
    Guangzhou Salustier Biosciences Co.
    12/20/23
  65. 53
    5-HT2A RECEPTOR INHIBITOR OR INVERSE AGONIST, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    Geneora Pharma (Shijiazhuang) Co.
    12/20/23
  66. 37
    A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION
    Taiho Pharmaceutical Co.
    12/20/23
  67. 16
    BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF
    Pharmaxis
    12/20/23
  68. 33
    BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
    The Trustees Of Columbia University In The City Of New York
    12/20/23
  69. 32
    Benzimidazole derivatives
    Hoffmann-La Roche
    12/20/23
  70. 319
    CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE
    Genzyme
    12/20/23
  71. 176
    GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES
    Idorsia Pharmaceuticals
    12/20/23
  72. 29
    HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF
    Iomx Therapeutics
    12/20/23
  73. 262
    HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    SchröDinger
    12/20/23
  74. 23
    Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof
    Zhejiang Hisun Pharmaceutical Co.
    12/20/23
  75. 27
    IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
    Deutsches Krebsforschungszentrum
    12/20/23
  76. 623
    OXOPYRROLIDINE FPR2 AGONISTS
    Bristol-Myers Squibb
    12/20/23
  77. 3
    PYRROLIDINE COMPOUND AND USE THEREOF
    Simcere Pharmaceutical Co.
    12/20/23
  78. 163
    QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
    Repare Therapeutics
    12/20/23
  79. 30
    SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS
    Xinthera
    12/20/23
  80. 7
    SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF
    Shanghai Senhui Medicine Co.
    12/20/23
  81. 24
    2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase
    Oxford Drug Design
    12/13/23
  82. 105
    2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors
    Merck Sharp & Dohme
    12/13/23
  83. 64
    Azetidine and pyrrolidine PARP1 inhibitors and uses thereof
    Xinthera
    12/13/23
  84. 21
    Compounds for the modulation of cyclophilins function
    The University Court Of The University Of Edinburgh
    12/13/23
  85. 481
    Cyclobutyl amide monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    12/13/23
  86. 76
    Glutarimides for medical treatment
    C4 Therapeutics
    12/13/23
  87. 188
    Heterocyclic compounds as monoacylglycerol lipase inhibitors
    Hoffmann-La Roche
    12/13/23
  88. 131
    AMINO ALCOHOL COMPOUNDS AND USES THEREOF
    Kineta
    12/10/23
  89. 264
    BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS
    Otsuka Pharmaceutical
    12/10/23
  90. 153
    CASEIN KINASE 1 DELTA MODULATORS
    Janssen Pharmaceutica
    12/10/23
  91. 29
    COMPOUNDS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISORDERS
    1St Biotherapeutics
    12/10/23
  92. 9
    HPK1 INHIBITORS AND USES THEREOF
    Qilu Regor Therapeutics
    12/10/23
  93. 4
    INDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR PARTIAL AGONISTS
    Research Triangle Institute
    12/10/23
  94. 197
    KRAS G12D MODULATING COMPOUNDS
    Gilead Sciences
    12/10/23
  95. 187
    MACROCYCLIC HETEROCYCLES AND USES THEREOF
    Kumquat Biosciences
    12/10/23
  96. 59
    MODULATORS OF ALPHA-1 ANTITRYPSIN
    Vertex Pharmaceuticals
    12/10/23
  97. 19
    NOVEL PHARMACOLOGICAL CHAPERONE COMPOUNDS OF HUMAN ACID ALPHA-GLUCOSIDASE AND THE THERAPEUTIC USE THEREOF
    UniversitÉ
    12/10/23
  98. 60
    SHP2 INHIBITOR AND COMPOSITION AND APPLICATION THEREOF
    Betta Pharmaceuticals
    12/10/23
  99. 555
    STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS
    Asteroid Therapeutics
    12/10/23
  100. 54
    SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
    Bayer Aktiengesellschaft
    12/10/23
  101. 128
    URACIL DERIVATIVES AS MER-AXL INHIBITORS
    Bristol-Myers Squibb
    12/10/23
  102. 37
    Compounds and pharmaceutical uses thereof
    Syneurx International (Taiwan
    12/05/23
  103. 9
    Compounds for the treatment of SARS
    Purdue Research Foundation
    12/05/23
  104. 97
    MAP4K4 inhibitors
    Imperial College Innovations
    12/05/23
  105. 122
    Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors
    Valo Health
    12/05/23
  106. 30
    Substituted pyridines as PARP1 inhibitors
    Xinthera
    12/05/23
  107. 51
    Tetrahydro-benzoazepine glycosidase inhibitors
    Asceneuron
    12/05/23
  108. 3
    Uses of a lysyl oxidase-like 2 inhibitor
    Pharmakea
    12/05/23
  109. 78
    AROMATIC ETHYLENE COMPOUND AND PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
    Guangzhou Maxinovel Pharmaceuticals
    12/01/23
  110. 1
    INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME
    Chia Tai Tianqing Pharmaceutical Group
    12/01/23
  111. 73
    INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
    University Of Virginia Patent Foundation
    12/01/23
  112. 1
    N-((1-BENZYLPIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)NAPHTHALENE-2-SULFONAMIDE FOR THE TREATMENT OF CANINE COGNITIVE DYSFUNCTION AND OTHER FORMS OF DEMENTIA IN DOGS
    Univerza V Ljubljani
    12/01/23
  113. 7
    NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS
    Enanta Pharmaceuticals
    12/01/23
  114. 15
    Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same
    Optikira
    12/01/23
  115. 18
    5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2 Pyridyl]Amino]Pyrazine-2-carbonitrile and therapeutic uses thereof
    Cancer Research Technology
    11/29/23
  116. 165
    Aryl piperidines as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    11/29/23
  117. 79
    Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof
    Shanghai Ennovabio Pharmaceuticals
    11/29/23
  118. 142
    Diacylglyceride O-acyltransferase 2 inhibitors
    Merck Sharp & Dohme
    11/29/23
  119. 157
    Dihydrobenzimidazolones for medical treatment
    C4 Therapeutics
    11/29/23
  120. 7
    Inhibiting ataxia telangiectasia and RAD3-related protein (ATR)
    Celator Pharmaceuticals
    11/29/23
  121. 94
    Inhibitors of VAP-1
    Acucela
    11/29/23
  122. 2
    Isoquinolinyl triazolone complexes
    Takeda Pharmaceutical
    11/29/23
  123. 8
    Methods of inhibiting cyclooxygenase
    King Faisal University
    11/29/23
  124. 150
    Plasma Kallikrein inhibitors and uses thereof
    Takeda Pharmaceutical
    11/29/23
  125. 46
    Pyrazolopyrimidine compounds as adenosine receptor antagonists
    Exscientia
    11/29/23
  126. 255
    Quaternary indazole glucocorticoid receptor antagonists
    Corcept Therapeutics
    11/29/23
  127. 2
    Solid forms of an HPK1 inhibitor
    Incyte
    11/29/23
  128. 34
    Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors
    Ildong Pharmaceutical
    11/29/23
  129. 46
    Therapeutic compounds and methods of use
    Genentech
    11/29/23
  130. 27
    ARYL PHOSPHOROUS OXIDE COMPOUNDS AND USE THEREOF
    Chengdu Di''Ao Jiuhong Pharmaceutical Factory
    11/22/23
  131. 137
    ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF
    Bayer Aktiengesellschaft
    11/22/23
  132. 85
    BROAD SPECTRUM ANTI-CANCER COMPOUNDS
    The Regents Of The University Of California
    11/22/23
  133. 14
    CDK9 INHIBITORS
    Biolexis Therapeutics
    11/22/23
  134. 3
    COMBINATION THERAPY
    Pfizer
    11/22/23
  135. 5
    FUSED IMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Jiangsu Hengrui Medicine
    11/22/23
  136. 37
    FUSED TRICYCLIC DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF
    Chia Tai Tianqing Pharmaceutical Group
    11/22/23
  137. 32
    HETEROAROMATIC RING COMPOUND AS RET KINASE INHIBITOR, AND PREPARATION AND USE THEREOF
    Jiangsu Chia Tai Fenghai Pharmaceutical
    11/22/23
  138. 29
    IMIDAZOTRIAZINE AND PYRROLOPYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS
    Beigene
    11/22/23
  139. 326
    NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
    Sage Therapeutics
    11/22/23
  140. 32
    NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF
    Lg Chem
    11/22/23
  141. 178
    OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF
    Eikonizo Therapeutics
    11/22/23
  142. 174
    PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Broadenbio
    11/22/23
  143. 16
    TRIAZOLE DERIVATIVES AND THEIR USE AS TANKYRASE INHIBITORS
    Oslo Universitetssykehus
    11/22/23
  144. 9
    UNIT DOSAGE COMPOSITION OF AKT INHIBITOR
    Nanjing Chia Tai Tianqing Pharmaceutical
    11/22/23
  145. 1441
    FGFR inhibitors and methods of use thereof
    Relay Therapeutics
    11/17/23
  146. 253
    Imino sulfanone inhibitors of ENPP1
    Volastra Therapeutics
    11/17/23
  147. 56
    LRRK2 inhibitors
    H. Lundbeck
    11/17/23
  148. 281
    Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D Ip
    11/17/23
  149. 57
    Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors
    Orsobio
    11/17/23
  150. 15
    Prolyl hydroxylase domain-containing protein (PHD) inhibitors and uses thereof
    Insilico Medicine Ip
    11/17/23
  151. 20
    Pyridinamine-pyridone and pyrimidinamine-pyridone compounds
    Sprint Bioscience
    11/17/23
  152. 46
    Substituted 3-phenoxyazetidin-1-yl-pyrazines
    Boehringer Ingelheim International
    11/17/23
  153. 93
    Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors
    Pfizer
    11/17/23
  154. 34
    TYK2 pseudokinase ligands
    Ventyx Biosciences
    11/17/23
  155. 9
    1-(5-(2-CYANOPYRIDIN-4-YL)OXAZOLE-2-CARBONYL)-4-METHYLHEXAHYDROPYRROLO[3,4-B]PYR ROLE-5(1H)-CARBONITRILE AS USP30 INHIBITOR FOR USE IN THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION, CANCER AND FIBROSIS
    Mission Therapeutics
    11/13/23
  156. 21
    1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS
    Shengke Pharmaceuticals (Jiangsu
    11/13/23
  157. 176
    2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
    Merck Sharp & Dohme
    11/13/23
  158. 118
    4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER
    Centre National De La Recherche Scientifique
    11/13/23
  159. 87
    ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Sichuan Kelun-Biotech Biopharmaceutical
    11/13/23
  160. 27
    COMPOUNDS WITH SEMIOCHEMICAL PROPERTIES AND BIOSENSORS
    Rothamsted Research
    11/13/23
  161. 51
    CYP46A1 INHIBITORS AND METHODS OF USE THEREOF
    Sage Therapeutics
    11/13/23
  162. 67
    HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF
    Mitsubishi Tanabe Pharma
    11/13/23
  163. 229
    N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES
    Astrazeneca
    11/13/23
  164. 46
    PTERIDINONE COMPOUNDS AND USES THEREOF
    Vertex Pharmaceuticals
    11/13/23
  165. 13
    PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF
    Wenzhou Medical University
    11/13/23
  166. 236
    PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
    Biosplice Therapeutics
    11/13/23
  167. 1
    QUINOLINE COMPOUNDS
    Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory
    11/13/23
  168. 12
    RING-MODIFIED PROLINE SHORT PEPTIDE COMPOUND AND USE THEREOF
    Fujian Akeylink Biotechnology
    11/13/23
  169. 2
    Salts Of Nitrogen-Containing Heterocyclic Compound, And Solid Forms Of Salts, Pharmaceutical Composition And Use Thereof
    Wuhan Humanwell Innovative Drug Research And Development Center
    11/13/23
  170. 39
    THIAZOLO[5,4-B]PYRIDINE MALT-1 INHIBITORS
    Abbvie
    11/13/23
  171. 396
    Furin inhibitors
    Glaxosmithkline Intellectual Property Development
    11/07/23
  172. 84
    Methods and compounds for treating disorders
    Foghorn Therapeutics
    11/07/23
  173. 8
    Substituted pyridines as DNMT1 inhibitors
    Glaxosmithkline Intellectual Property Development
    11/07/23
  174. 258
    2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Merck Sharp & Dohme
    11/06/23
  175. 59
    4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF
    Suvalent Therapeutics
    11/06/23
  176. 39
    BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
    Academy Of Military Medical Sciences
    11/06/23
  177. 9
    BENZYLAMINE OR BENZYL ALCOHOL DERIVATIVE AND USES THEREOF
    Chengdu Hyperway Pharmaceuticals
    11/06/23
  178. 53
    CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Jiangsu Tasly Diyi Pharmaceutical
    11/06/23
  179. 5
    COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA
    Stealth Biotherapeutics
    11/06/23
  180. 1
    CRYSTALLINE FORM OF TLR8 AGONIST
    Chia Tai Tianqing Pharmaceutical Group
    11/06/23
  181. 91
    MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF
    Children'S Hospital Medical Center
    11/06/23
  182. 12
    N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS
    Mission Therapeutics
    11/06/23
  183. 2
    ORALLY BIOAVAILABLE, BRAIN-PENETRANT COMPOUND WITH SELECTIVITY FOR THE CANNABINOID TYPE 2 RECEPTOR WITH POTENTIAL USE TOWARDS VISCERAL PAIN MANAGEMENT AND NEURODEGENERATIVE DISORDERS
    University Of Mississippi
    11/06/23
  184. 73
    OXOPYRROLIDINE UREA FPR2 AGONISTS
    Bristol-Myers Squibb
    11/06/23
  185. 13
    PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG
    Ideaya Biosciences
    11/06/23
  186. 11
    PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Sichuan Kelun-Biotech Biopharmaceutical
    11/06/23
  187. 13
    PYRIMIDINE RING COMPOUND
    Medshine Discovery
    11/06/23
  188. 13
    Advantageous benzofuran compositions for mental disorders or enhancement
    Tactogen
    11/02/23
  189. 43
    Glucose-sensitive albumin-binding derivatives
    Novo Nordisk
    11/02/23
  190. 18
    Nicotinamide RIPK1 inhibitors
    Abbvie
    11/02/23
  191. 44
    Tricyclic pyridone compounds as JAK2 V617F inhibitors
    Incyte
    11/02/23
  192. 357
    3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS
    Janssen Pharmaceutica
    10/30/23
  193. 258
    ANTAGONIST COMPOUNDS
    Adorx Therapeutics
    10/30/23
  194. 47
    ATR INHIBITORS AND USES THEREOF
    Antengene Discovery
    10/30/23
  195. 29
    ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Suzhou Ark Biopharmaceutical
    10/30/23
  196. 32
    CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF
    Risen (Suzhou) Pharma Tech
    10/30/23
  197. 170
    COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF
    Tyk Medicines
    10/30/23
  198. 128
    FUSED HETEROAROMATIC PYRROLIDINONES
    Calithera Biosciences
    10/30/23
  199. 6
    INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS
    Sanford Burnham Prebys Medical Discovery Institute
    10/30/23
  200. 94
    INHIBITORS OF VAP-1
    Acucela
    10/30/23
  201. 137
    INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS
    Pliant Therapeutics
    10/30/23
  202. 36
    NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    Chong Kun Dang Pharmaceutical
    10/30/23
  203. 67
    PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
    Akebia Therapeutics
    10/30/23
  204. 115
    SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES
    Idorsia Pharmaceuticals
    10/30/23
  205. 329
    SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Gossamer Bio Services
    10/30/23
  206. 44
    Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors
    University Of Maryland, Baltimore
    10/29/23
  207. 75
    Methods and compositions for targeting PD-L1
    Aligos Therapeutics
    10/29/23
  208. 9
    Steroids and protein-conjugates thereof
    Regeneron Pharmaceuticals
    10/29/23
  209. 11
    TKI permeability enhancers
    City Of Hope
    10/29/23
  210. 59
    1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES
    Duksung Women''S University Industry-Academic Cooperation Foundation
    10/23/23
  211. 96
    ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE
    Petra Pharma
    10/23/23
  212. 120
    BCL6 INHIBITORS
    Cancer Research Technology
    10/23/23
  213. 90
    Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Board Of Regents Of The University Of Texas System
    10/23/23
  214. 56
    HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Huyabio International
    10/23/23
  215. 139
    IL-17A MODULATORS
    Sanofi
    10/23/23
  216. 13
    INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Disarm Therapeutics
    10/23/23
  217. 238
    ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
    Biosplice Therapeutics
    10/23/23
  218. 47
    KCNT1 INHIBITORS AND METHODS OF USE
    Praxis Precision Medicines
    10/23/23
  219. 10
    METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION
    Beijing Tide Pharmaceutical
    10/23/23
  220. 58
    NEPRILYSIN INHIBITORS
    Theravance Biopharma R&D Ip
    10/23/23
  221. 417
    NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS
    Italfarmaco
    10/23/23
  222. 33
    PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Huyabio International
    10/23/23
  223. 185
    PLASMA KALLIKREIN INHIBITORS
    Merck Sharp & Dohme
    10/23/23
  224. 32
    QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
    Inipharm
    10/23/23
  225. 3
    SALT OF DIHYDROPYRIDO[2,3-D]PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Nanjing Chia Tai Tianqing Pharmaceutical
    10/23/23
  226. 30
    Disulfiram derivatives as ALDH1A1 and MAGL inhibitors
    Batterjee Medical College
    10/20/23
  227. 295
    EIF4E inhibitors and uses thereof
    Pic Therapeutics
    10/20/23
  228. 34
    Muscarinic acetylcholine M1 receptor antagonists
    Pipeline Therapeutics
    10/20/23
  229. 55
    Protease inhibitors as antivirals
    Acea Therapeutics
    10/20/23
  230. 137
    Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase
    Vanderbilt University
    10/20/23
  231. 57
    Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
    Rugen Holdings (Cayman
    10/20/23
  232. 187
    DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
    Inipharm
    10/18/23
  233. 54
    Benzimidazole Derivative Compounds and Uses Thereof
    Pfizer
    10/17/23
  234. 1030
    CARM1 INHIBITORS AND USES THEREOF
    Epizyme
    10/17/23
  235. 37
    CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS
    Astrazeneca
    10/17/23
  236. 207
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Plexxikon
    10/17/23
  237. 143
    Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof
    280 Bio
    10/17/23
  238. 5
    DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
    Arena Pharmaceuticals
    10/17/23
  239. 34
    ENPP1 Inhibitors and Their Use for the Treatment of Cancer
    The Board Of Trustees Of The Leland Stanford Junior University
    10/17/23
  240. 4
    IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Hoffmann-La Roche
    10/17/23
  241. 90
    INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER
    Universite Claude Bernard Lyon 1
    10/17/23
  242. 461
    KRAS G12D INHIBITORS
    Mirati Therapeutics
    10/17/23
  243. 160
    N/O-Linked Degrons and Degronimers for Protein Degradation
    C4 Therapeutics
    10/17/23
  244. 7
    NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Shanghai Longwood Biopharmaceuticals
    10/17/23
  245. 26
    PTGR2 INHIBITORS AND THEIR USE
    National Health Research Institutes
    10/17/23
  246. 20
    ROR-GAMMA MODULATORS
    Escalier Biosciences
    10/17/23
  247. 29
    TRIAZINE COMPOUND AND COMPOSITION AND USE THEREOF
    Beijing Findcure Biosciences
    10/17/23
  248. 188
    YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Molecure
    10/17/23
  249. 98
    5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER
    Astrazeneca
    10/16/23
  250. 100
    AMIDE DERIVATIVES
    Merck Patent
    10/16/23
  251. 144
    AMINO ACID COMPOUNDS AND METHODS OF USE
    Pliant Therapeutics
    10/16/23
  252. 44
    COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
    Ono Pharmaceutical
    10/16/23
  253. 549
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    Vertex Pharmaceuticals
    10/16/23
  254. 250
    COMPOUNDS USEFUL AS T CELL ACTIVATORS
    Gossamer Bio Services
    10/16/23
  255. 20
    CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Disarm Therapeutics
    10/16/23
  256. 5
    PRPK INHIBITORS
    Dana-Farber Cancer Institute
    10/16/23
  257. 24
    PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR
    Beijing Tide Pharmaceutical
    10/16/23
  258. 3
    SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
    Nanjing Chia Tai Tianqing Pharmaceutical
    10/16/23
  259. 42
    4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS
    Ip2Ipo Innovations
    10/15/23
  260. 210
    BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Reviral
    10/15/23
  261. 164
    CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR
    Bayer Pharma Aktiengesellschaft
    10/15/23
  262. 176
    COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE
    Chugai Seiyaku Kabushiki Kaisha
    10/15/23
  263. 124
    COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
    Nuevolution
    10/15/23
  264. 76
    COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
    Ifm Due
    10/15/23
  265. 412
    GLP-1R MODULATING COMPOUNDS
    Ascletis Bioscience
    10/15/23
  266. 129
    INHIBITORS OF APOL1 AND METHODS OF USING SAME
    Vertex Pharmaceuticals
    10/15/23
  267. 135
    SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF
    Gilead Sciences
    10/15/23
  268. 162
    2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
    1St Biotherapeutics
    10/06/23
  269. 56
    ALK-5 inhibitors and uses thereof
    Sumitomo Pharma Oncology
    10/06/23
  270. 16
    Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
    Shenzhen Targetrx
    10/06/23
  271. 43
    Labelled cannabinergic ligands and related analogs
    Individual
    10/06/23
  272. 10
    Method of increasing platelet counts of a subject
    Korea Basic Science Institute
    10/06/23
  273. 31
    Acetamido-phenyltetrazole derivatives and methods of using the same
    Athenex
    10/01/23
  274. 125
    Methods of inhibiting kinases
    Insilico Medicine Ip
    10/01/23
  275. 22
    Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof
    Insilico Medicine Ip
    10/01/23
  276. 10
    Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors
    Jumbo Drug Bank
    10/01/23
  277. 5
    Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
    Revolution Medicines
    10/01/23
  278. 105
    Carboxamide compounds and uses thereof
    Incyte
    09/26/23
  279. 36
    Histone demethylase inhibitors
    Celgene Quanticel Research
    09/26/23
  280. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda
    09/26/23
  281. 93
    SARS-CoV-2 inhibitors for treating coronavirus infections
    Insilico Medicine Ip
    09/26/23
  282. 58
    Spiro compounds as glycosidase inhibitors
    Asceneuron
    09/26/23
  283. 106
    Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
    Alumis
    09/26/23
  284. 31
    Substituted pyrazolo[3,4-d]pyrimidines as mTOR inhibitors
    Galderma Research & Development
    09/26/23
  285. 41
    HDAC inhibitor compounds and methods of treatment
    University Of Florida Research Foundation
    09/25/23
  286. 298
    Therapeutic compounds, compositions and methods of use thereof
    Genentech
    09/25/23
  287. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics
    09/23/23
  288. 253
    Bicyclic compound and use thereof
    Sk Biopharmaceuticals
    09/23/23
  289. 3
    Bicyclic urea kinase inhibitors and uses thereof
    The General Hospital
    09/23/23
  290. 43
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics
    09/23/23
  291. 151
    Polyheterocyclic compounds as METTL3 inhibitors
    Storm Therapeutics
    09/23/23
  292. 415
    Apoptosis inhibitors
    National Institute Of Biological Sciences, Beijing
    09/21/23
  293. 176
    Compounds and compositions for treating conditions associated with NLRP activity
    Novartis
    09/21/23
  294. 80
    MCT4 inhibitors for treating disease
    Vettore
    09/21/23
  295. 49
    Methods of improving cell-based therapy
    The Regents Of The University Of California
    09/21/23
  296. 52
    Quinazoline derivatives as antitumor agents
    Suzhou Zanrong Pharma
    09/21/23
  297. 222
    Heterocyclic adenosine receptor antagonists
    Exelixis
    09/17/23
  298. 63
    Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
    Ardelyx
    09/17/23
  299. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    09/17/23
  300. 223
    Macrocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    09/17/23
  301. 19
    N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors
    The Regents Of The University Of Michigan
    09/17/23
  302. 106
    Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors
    Neurocrine Biosciences
    09/17/23
  303. 1
    Benzenesulfonylbenazamide compound for inhibiting BCL-2 protein and composition and use thereof
    Shenzhen Targetrx
    09/15/23
  304. 570
    CDK2 inhibitors
    Pfizer
    09/15/23
  305. 164
    Compositions and methods of modulating short-chain dehydrogenase
    Case Western Reserve University
    09/15/23
  306. 25
    Heparanase inhibitors and use thereof
    Beta Therapeutics
    09/15/23
  307. 13
    Heterocyclic compounds as immunomodulators
    Incyte
    09/15/23
  308. 70
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board Of Regents, The University Of Texas System
    09/15/23
  309. 3
    Treatment of spondyloarthritis
    Pharmacyl
    09/15/23
  310. 107
    Azole derivatives as apelin receptor agonist
    Sanford Burnham Prebys Medical Discovery Institute
    09/08/23
  311. 5
    Bismuth(III) compounds and methods thereof
    The University Of Hong Kong
    09/08/23
  312. 3
    Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
    Chia Tai Tianqing Pharmaceutical Group
    09/08/23
  313. 187
    Cyanotriazole compounds
    Otsuka Pharmaceutical
    09/08/23
  314. 9
    Heterocyclic indoles for use in influenza virus infection
    Janssen Sciences Ireland Uc
    09/08/23
  315. 420
    Heterocyclic sulfonamide derivative and medicine comprising same
    Ea Pharma
    09/08/23
  316. 117
    Inhibitor of lysine specific demethylase-1
    Celgene Quanticel Research
    09/08/23
  317. 332
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    Sanford Burnham Prebys Medical Discovery Institute
    09/08/23
  318. 42
    Peptide derivatives and uses thereof
    Nosopharm
    09/08/23
  319. 14
    Phosphodiesterase inhibitors and uses thereof
    The Trustees Of Columbia University In The City Of New York
    09/08/23
  320. 216
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Bayer Aktiengesellschaft
    09/04/23
  321. 12
    5 to 7 membered heterocyclic amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    09/04/23
  322. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Biosplice Therapeutics
    09/04/23
  323. 39
    5-substituted difluoropiperidine compounds with blood-brain barrier penetrable capability
    Wayshine Biopharm Holding
    09/04/23
  324. 44
    GSK-3 inhibitors
    Bristol-Myers Squibb
    09/04/23
  325. 26
    Heteroaryl heterocyclyl compounds for the treatment of autoimmune disease
    Hoffmann-La Roche
    09/04/23
  326. 102
    Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases
    Chemocentryx
    09/04/23
  327. 44
    Inhibitors of NEK7 kinase
    Halia Therapeutics
    09/04/23
  328. 218
    Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1
    Cancer Research Technology
    08/31/23
  329. 44
    Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators
    Idorsia Pharmaceuticals
    08/31/23
  330. 267
    Protein kinase modulators
    Cylene Pharmaceuticals
    08/31/23
  331. 563
    Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    08/27/23
  332. 92
    Azaindole derivatives and their use as ERK kinase inhibitors
    Agv Discovery
    08/27/23
  333. 30
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    08/27/23
  334. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    The Board Of Trustees Of The Leland Stanford Junior University
    08/27/23
  335. 89
    FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto
    Trustees Of Tufts College
    08/27/23
  336. 34
    Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
    Novartis
    08/27/23
  337. 250
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    08/27/23
  338. 410
    Immunomodulator compounds
    Chemocentryx
    08/27/23
  339. 122
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    08/27/23
  340. 536
    Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
    Biocryst Pharmaceuticals
    08/27/23
  341. 98
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    08/18/23
  342. 364
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer
    08/18/23
  343. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    Genuv
    08/18/23
  344. 36
    Compounds and methods of use
    Medivation Technologies
    08/18/23
  345. 2
    Crystalline hydrate of a JAK inhibitor compound
    Theravance Biopharma R&D Ip
    08/18/23
  346. 34
    ENPP1 inhibitors and their use for the treatment of cancer
    The Board Of Trustees Of The Leland Stanford Junior University
    08/18/23
  347. 647
    Methods, compositions, and uses of novel FYN kinase inhibitors
    Pathways Neuro Pharma
    08/18/23
  348. 42
    Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
    D. E. Shaw Research
    08/18/23
  349. 94
    Pyrazolyl derivatives useful as anti-cancer agents
    Novartis
    08/18/23
  350. 34
    Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
    Revolution Medicines
    08/18/23
  351. 143
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent
    08/18/23
  352. 365
    SOS1 inhibitors
    Mirati Therapeutics
    08/18/23
  353. 9
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    08/18/23
  354. 303
    Thiadiazole IRAK4 inhibitors
    Gilead Sciences
    08/18/23
  355. 79
    Agent enhancing antitumor effect using pyrazolo[3,4-d]pyrimidine compound
    Taiho Pharmaceutical
    08/11/23
  356. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent
    08/11/23
  357. 42
    Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors
    Eil Therapeutics
    08/11/23
  358. 264
    Fused pyrimidine pyridinone compounds as JAK inhibitors
    Theravance Biopharma R&D Ip
    08/11/23
  359. 318
    Substituted benzamides
    Hoffmann-La Roche
    08/11/23
  360. 15
    2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
    Boehringer Ingelheim International
    08/06/23
  361. 234
    6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
    Ajax Therapeutics
    08/06/23
  362. 44
    Compound having KDM5 inhibitory activity and pharmaceutical use thereof
    Ono Pharmaceutical
    08/06/23
  363. 82
    Cyclic ether derivatives of pyrazolo[1,5-A]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International
    08/06/23
  364. 80
    Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    Inventisbio
    08/06/23
  365. 101
    Inhibitors of receptor interacting protein kinase I for the treatment of disease
    Board Of Regents, The University Of Texas System
    08/06/23
  366. 93
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics
    08/06/23
  367. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals
    08/06/23
  368. 25
    MAGL inhibitors
    H. Lundbeck
    08/06/23
  369. 25
    Macrocyclic immunomodulators
    Chemocentryx
    08/06/23
  370. 51
    Macrocyclic indoles as Mcl-1 inhibitors
    Ascentage Pharma (Suzhou)
    08/06/23
  371. 1
    Method for preparing pyrrolidinyl urea derivative
    Zhangzhou Pien Tze Huang Pharmaceutical
    08/06/23
  372. 24
    Naphthyridinone compounds as JAK2 V617F inhibitors
    Incyte
    08/06/23
  373. 96
    Pyridazinones as PARP7 inhibtors
    Ribon Therapeutics
    08/06/23
  374. 217
    Therapeutic compounds and compositions
    Exithera Pharmaceuticals
    08/06/23
  375. 121
    ATM kinase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    07/31/23
  376. 106
    Azalactam compounds as HPK1 inhibitors
    Pfizer
    07/31/23
  377. 82
    C5a receptor modulators
    Idorsia Pharmaceuticals
    07/31/23
  378. 123
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics
    07/31/23
  379. 14
    Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
    Ocuterra Therapeutics
    07/31/23
  380. 245
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    07/31/23
  381. 491
    MYST family histone acetyltransferase inhibitors
    Epizyme
    07/31/23
  382. 24
    Pyridinone MK2 inhibitors and uses thereof
    Xinthera
    07/31/23
  383. 385
    Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
    Dart Neuroscience
    07/31/23
  384. 138
    Bicycloheptane pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme
    07/25/23
  385. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/25/23
  386. 22
    Compounds and compositions as protein kinase inhibitors
    Array Biopharma
    07/25/23
  387. 55
    Compounds useful as RET inhibitors
    Cancer Research Technology
    07/25/23
  388. 82
    MK2 inhibitors and uses thereof
    Xinthera
    07/25/23
  389. 2
    Methods of treating disorders using CSF1R inhibitors
    Deciphera Pharmaceuticals
    07/25/23
  390. 16
    Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors
    Mekanistic Therapeutics
    07/19/23
  391. 155
    5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
    Bristol-Myers Squibb
    07/16/23
  392. 40
    Amino pyrimidine derivatives
    Novartis
    07/16/23
  393. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche
    07/16/23
  394. 88
    CDK inhibitors and their use as pharmaceuticals
    Prelude Therapeutics
    07/16/23
  395. 35
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/16/23
  396. 11
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    07/16/23
  397. 51
    Heterocyclic compounds as immunomodulators
    Incyte
    07/16/23
  398. 13
    Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
    Great Novel Therapeutics Biotech & Medicals
    07/16/23
  399. 96
    Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
    Incyte
    07/16/23
  400. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Biosplice Therapeutics
    07/16/23
  401. 12
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals
    07/16/23
  402. 21
    Pharmaceutical compounds
    Sareum
    07/16/23
  403. 82
    Polycyclic compounds as allosteric SHP2 inhibitors
    Revolution Medicines
    07/16/23
  404. 159
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    07/16/23
  405. 7
    Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs
    Olema Pharmaceuticals
    07/16/23
  406. 50
    4-substitued cytisine analogues
    University Of Bristol
    07/09/23
  407. 7
    Antibody-drug conjugates comprising a cyclic dinucleotide
    Takeda Pharmaceutical
    07/09/23
  408. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    07/09/23
  409. 36
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    07/09/23
  410. 378
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    07/09/23
  411. 56
    FGFR4 inhibitor, preparation method therefor, and applications thereof
    Jiangsu Hansoh Pharmaceutical Group
    07/09/23
  412. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D Ip
    07/09/23
  413. 148
    Granzyme B directed imaging and therapy
    Cytosite Biopharma
    07/09/23
  414. 65
    Inhibitors of RAF kinases
    Kinnate Biopharma
    07/09/23
  415. 204
    MCL1 inhibitors
    Gilead Sciences
    07/09/23
  416. 97
    Methods of treating intraocular pressure with activators of Tie-2
    Eyepoint Pharmaceuticals
    07/09/23
  417. 80
    RIP1K inhibitors
    Rigel Pharmaceuticals
    07/09/23
  418. 206
    Therapeutically active compounds and their methods of use
    Servier Pharmaceuticals
    07/09/23
  419. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology
    07/03/23
  420. 496
    Imidazole-containing inhibitors of ALK2 kinase
    Biocryst Pharmaceuticals
    07/03/23
  421. 18
    Tetrazole derivatives as TRPA1 inhibitors
    Boehringer Ingelheim International
    07/03/23
  422. 8
    Thienopyrrole compounds
    Gilead Sciences
    07/03/23
  423. 26
    Tricyclic urea compounds as JAK2 V617F inhibitors
    Incyte
    07/03/23
  424. 54
    Benzimidazole derivative compounds and uses thereof
    Pfizer
    07/02/23
  425. 13
    MASP-2 inhibitors and methods of use
    Omeros
    07/02/23
  426. 129
    Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
    Chronos Therapeutics
    07/02/23
  427. 28
    Treatment of Rett syndrome
    Cold Spring Harbor Laboratory
    07/02/23
  428. 87
    Tricyclic compounds as histone methyltransferase inhibitors
    Global Blood Therapeutics
    07/02/23
  429. 170
    ALK2 inhibitors and methods for inhibiting BMP signaling
    The Brigham And Women's Hospital
    06/26/23
  430. 4
    Aminopyrimidinyl derivatives
    Pfizer
    06/26/23
  431. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    06/26/23
  432. 32
    Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    06/26/23
  433. 4
    Glucagon-like peptide1 receptor agonists
    Eli Lilly
    06/26/23
  434. 23
    Indolizine derivatives and their application in medicine
    Kind Pharmaceutical
    06/26/23
  435. 252
    Pyrazole MAGL inhibitors
    H. Lundbeck
    06/26/23
  436. 32
    Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
    Hoffmann-La Roche
    06/26/23
  437. 6
    Substituted piperazines as BTK inhibitors
    Hutchison Medipharma
    06/26/23
  438. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly
    06/19/23
  439. 98
    Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
    Petra Pharma
    06/19/23
  440. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals
    06/19/23
  441. 81
    C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    06/19/23
  442. 18
    Compound as mTOR inhibitor and use thereof
    Medicinal Bioconvergence Research Center
    06/19/23
  443. 18
    Halo-allylamine SSAO/VAP-1 inhibitor and use thereof
    Nanjing Transthera Biosciences
    06/19/23
  444. 663
    Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
    1St Biotherapeutics
    06/19/23
  445. 113
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Esteve Pharmaceuticals
    06/19/23
  446. 2
    Pan-tropic entry inhibitors
    Emory University
    06/19/23
  447. 14
    Pyrazolochlorophenyl compounds, compositions and methods of use thereof
    Genentech
    06/19/23
  448. 50
    Selective androgen receptor degrader (SARD) ligands and methods of use
    University Of Tennessee Research Foundation
    06/19/23
  449. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees Of Columbia University In The City Of New York
    06/19/23
  450. 228
    Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
    Optikira
    06/19/23
  451. 814
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    06/19/23
  452. 320
    Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
    Kumquat Biosciences
    06/19/23
  453. 2
    5-HT2A agonists for use in treatment of depression
    Lophora
    06/11/23
  454. 156
    BRD4-kinase inhibitors as cancer therapeutics
    H. Lee Moffitt Cancer Center And Research Institute
    06/11/23
  455. 8
    Compounds for degrading Tau protein aggregates and uses thereof
    Aprinoia Therapeutics
    06/11/23
  456. 9
    Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors
    Individual
    06/11/23
  457. 11
    GLP-1 receptor agonist and use thereof
    Ildong Pharmaceutical
    06/11/23
  458. 443
    MCL-1 inhibitors
    Gilead Sciences
    06/11/23
  459. 10
    Polypeptide compound, pharmaceutical composition, preparation method and application thereof
    Chengdu Sintanovo Biotechnology
    06/11/23
  460. 31
    Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors
    G1 Therapeutics
    06/11/23
  461. 46
    Substituted benzene compounds
    Epizyme
    06/11/23
  462. 144
    Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof
    Japan Tobacco
    06/11/23
  463. 155
    Amino acid compounds and methods of use
    Pliant Therapeutics
    06/02/23
  464. 192
    Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
    H. Lundbeck
    06/02/23
  465. 78
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array Biopharma
    06/02/23
  466. 18
    Diazaindole derivative and use thereof as CHK1 inhibitor
    Medshine Discovery
    06/02/23
  467. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    06/02/23
  468. 48
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    06/02/23
  469. 124
    Pharmaceutical compounds
    Pfizer
    06/02/23
  470. 93
    Pyrazoles
    Janssen Pharmaceuticals
    06/02/23
  471. 22
    Selective estrogen receptor degraders
    Eli Lilly
    06/02/23
  472. 53
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer
    06/02/23
  473. 99
    Substituted amino triazoles useful as chitinase inhibitors
    Molecure
    06/02/23
  474. 14
    Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors
    Luoxin Pharmaceutical (Shanghai)
    06/02/23
  475. 17
    6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
    Sprint Bioscience
    06/01/23
  476. 21
    Compounds and methods useful for treating or preventing cancers
    The Broad Institute
    06/01/23
  477. 253
    Compounds which are inhibitors of Notum
    Ucl Business
    06/01/23
  478. 9
    Method for controlling hematophagous or sap-feeding arthropods
    Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
    06/01/23
  479. 313
    Opioid receptor modulators
    Epiodyne
    06/01/23
  480. 90
    Selective D3 dopamine receptor agonists and methods of their use
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    06/01/23
  481. 19
    Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
    Sumitomo Pharma
    06/01/23
  482. 260
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutial
    06/01/23
  483. 14
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly
    05/27/23
  484. 39
    Lymphoid-specific tyrosine phosphatase (LYP) inhibitors
    Purdue Research Foundation
    05/27/23
  485. 111
    SHP2 phosphatase inhibitors and methods of use thereof
    D. E. Shaw Research
    05/27/23
  486. 46
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity
    Praxis Precision Medicines
    05/27/23
  487. 57
    Substituted pyridine derivatives as SARM1 inhibitors
    Nura Bio
    05/27/23
  488. 32
    Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
    Shionogi
    05/27/23
  489. 21
    Triazolo-pyrimidine compounds and uses thereof
    Dizal (Jiangsu) Pharmaceutical
    05/27/23
  490. 223
    Indole carboxamide compounds
    Bristol-Myers Squibb
    05/22/23
  491. 2
    Method of treatment with histamine-3 receptor inverse agonist
    Suven Life Sciences
    05/22/23
  492. 4
    Protein degraders and uses thereof
    Kymera Therapeutics
    05/22/23
  493. 15
    Spirocyclic compounds
    C4 Therapeutics
    05/22/23
  494. 19
    Uracil compound as c-MET/AXL inhibitor
    Medshine Discovery
    05/22/23
  495. 20
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    05/11/23
  496. 1532
    Aminopyrrolotriazines as kinase inhibitors
    Bristol-Myers Squibb
    05/11/23
  497. 186
    Benzoimidazoles as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica
    05/11/23
  498. 18
    Compounds active towards nuclear receptors
    Nuevolution
    05/10/23
  499. 19
    Heterocyclic compounds as immunomodulators
    Incyte
    05/10/23
  500. 36
    Oxysterols and methods of use thereof
    Sage Therapeutics
    05/10/23
  501. 83
    Substituted pyridotriazine compounds and uses thereof
    Gilead Sciences
    05/10/23
  502. 24
    3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
    Shaanxi Panlong Pharmaceutical
    05/09/23
  503. 302
    8-aminoisoquinoline compounds and uses thereof
    Genentech
    05/09/23
  504. 116
    Enzyme inhibitors
    Kalvista Pharmaceuticals
    05/09/23
  505. 123
    Glycosidase inhibitors
    Asceneuron
    05/09/23
  506. 167
    Inhibitors of RHO associated coiled-coil containing protein kinase
    Kadmon
    05/09/23
  507. 10
    Pharmaceutical formulations comprising CCR3 antagonists
    Alkahest
    05/09/23
  508. 62
    Substituted condensed thiophenes as modulators of sting
    Ctxt Pty
    05/09/23
  509. 22
    Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
    Industrial Technology Research Institute
    05/05/23
  510. 106
    Bicyclic amide compounds and methods of use thereof
    Genentech
    05/05/23
  511. 9
    Curcumin analogues as zinc chelators and their uses
    The Research Foundation For The State University Of New York
    05/05/23
  512. 42
    FGFR4 inhibitor and preparation method and use thereof
    Jiangsu Hansoh Pharmaceutical Group
    05/05/23
  513. 40
    Heterocyclic compounds as immunomodulators
    Incyte
    05/05/23
  514. 138
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent
    05/05/23
  515. 161
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    The Institute Of Cancer Research: Royal Cancer Hospital
    05/05/23
  516. 93
    Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
    Hoffmann-La Roche
    05/05/23
  517. 5
    PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
    H. Lundbeck
    05/05/23
  518. 19
    Compounds and therapeutic uses thereof
    Viogen Biosciences
    04/30/23
  519. 64
    MTORC1 modulators and uses thereof
    Aeovian Pharmaceuticals
    04/30/23
  520. 285
    PCSK9 inhibitors and methods of use thereof
    Astrazeneca
    04/30/23
  521. 34
    Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
    Array Biopharma
    04/30/23
  522. 19
    Compounds and compositions for the treatment of parasitic diseases
    Novartis
    04/23/23
  523. 53
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    04/23/23
  524. 10
    Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
    The Royal Institution For The Advancement Of Learning/Mcgill University
    04/23/23
  525. 26
    JAK1 pathway inhibitors for the treatment of gastrointestinal disease
    Incyte
    04/23/23
  526. 427
    Monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    04/23/23
  527. 20
    PD-L1/STING conjugates and methods of use
    Incyte
    04/23/23
  528. 4
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    04/23/23
  529. 3
    SHP2 inhibitor compositions and methods for treating cancer
    Revolution Medicines
    04/23/23
  530. 719
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    04/23/23
  531. 28
    Benzamide compounds
    Recurium Ip Holdings
    04/14/23
  532. 26
    Bicyclic heterocycles as FGFR inhibitors
    Incyte
    04/14/23
  533. 13
    Bipyrazole derivatives as JAK inhibitors
    Incyte
    04/14/23
  534. 27
    Certain chemical compositions and methods of use thereof
    Algen Biotechnologies
    04/14/23
  535. 164
    Compounds, compositions, and methods
    Denali Therapeutics
    04/14/23
  536. 46
    Heterocyclic compound, application thereof and pharmaceutical composition comprising same
    Suzhou Sinovent Pharmaceuticals
    04/14/23
  537. 26
    Highly active CSF1R inhibitor compound
    Xiamen Biotime Biotechnology
    04/14/23
  538. 25
    Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
    Hinova Pharmaceuticals
    04/14/23
  539. 40
    Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof
    Stingray Therapeutics
    04/14/23
  540. 73
    Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
    Pharmablock Sciences (Nanjing
    04/14/23
  541. 14
    Oxazolidinone antibiotic compounds and process of preparation
    Bugworks Research
    04/14/23
  542. 99
    PARP1 inhibitors and uses thereof
    Xinthera
    04/14/23
  543. 3
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    04/14/23
  544. 144
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte
    04/14/23
  545. 51
    Small molecule inducers of autophagy
    Board Of Regents, The University Of Texas System
    04/14/23
  546. 514
    Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
    D. E. Shaw Research
    04/14/23
  547. 4
    Amino alcohol derivative, pharmaceutical composition and application thereof
    Beijing Foreland Pharma
    04/09/23
  548. 15
    Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
    Shanghai Yingli Pharmaceutical
    04/09/23
  549. 6
    Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
    Stealth Biotherapeutics
    04/09/23
  550. 13
    Dash inhibitors, and uses related thereto
    Trustees Of Tufts College
    04/09/23
  551. 165
    Dihydrothieno[3,2-b]pyridine compounds
    Ideaya Biosciences
    04/09/23
  552. 33
    Heterocyclic compounds as BET inhibitors
    Nuvation Bio
    04/09/23
  553. 27
    Inhibitors of EGFR and methods of use thereof
    Dana-Farber Cancer Institute
    04/09/23
  554. 479
    MASP-2 inhibitors and methods of use
    Omeros
    04/09/23
  555. 22
    Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
    Heptares Therapeutics
    04/09/23
  556. 57
    RIP1K inhibitors
    Rigel Pharmaceuticals
    04/09/23
  557. 2
    Solid forms of a plasma kallikrein inhibitor and salts thereof
    Kalvista Pharmaceuticals
    04/09/23
  558. 80
    Spirocyclic compounds
    C4 Therapeutics
    04/09/23
  559. 225
    Substituted pyridopyrimidinonyl compounds useful as T cell activators
    Bristol-Myers Squibb
    04/09/23
  560. 145
    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
    Venenum Biodesign
    04/09/23
  561. 73
    Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International
    04/09/23
  562. 21
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    03/31/23
  563. 227
    Condensed ring compounds having dopamine D3 receptor antagonistic effect
    Shionogi
    03/31/23
  564. 289
    Fluoroalkyl-oxadiazoles and uses thereof
    Tenaya Therapeutics
    03/31/23
  565. 22
    Heterocyclic RIP1 inhibitory compounds
    Rigel Pharmaceuticals
    03/31/23
  566. 3
    Heterocyclic compounds for inhibiting TYK2 activities
    Beijing Innocare Pharma Tech
    03/31/23
  567. 20
    Inhibiting mutant IDH-1
    Forma Therapeutics
    03/31/23
  568. 282
    Inhibitors of LRRK2 kinase
    Halia Therapeutics
    03/31/23
  569. 72
    Spiro-oxazolones
    Hoffmann-La Roche
    03/31/23
  570. 64
    Therapeutic agent for non-motor symptoms associated with Parkinson's disease
    Sumitomo Pharma
    03/31/23
  571. 23
    Thienopyrimidones
    Boehringer Ingelheim International
    03/31/23
  572. 29
    Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
    Beijing Innocare Pharma Tech
    03/26/23
  573. 44
    Antibacterial agents: arylalkylcarboxamido phloroglucinols
    Rutgers, The State University Of New Jersey
    03/26/23
  574. 4
    BRD4 inhibitor
    Hinova Pharmaceuticals
    03/26/23
  575. 14
    Cyanoaryl-aniline compounds for treatment of dermal disorders
    Nflection Therapeutics
    03/26/23
  576. 40
    Heterocyclic compounds as immunomodulators
    Incyte
    03/26/23
  577. 26
    Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
    University Health Network
    03/26/23
  578. 171
    Inhibitors of histone deacetylase
    The General Hospital
    03/26/23
  579. 452
    N-cyano-7-azanorbornane derivatives and uses thereof
    Amgen
    03/26/23
  580. 38
    Pyrazine compounds and uses thereof
    Dizal (Jiangsu) Pharmaceutical
    03/26/23
  581. 73
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences
    03/26/23
  582. 69
    Bicyclic heterocycles as FGFR inhibitors
    Incyte
    03/20/23
  583. 4
    Heterocyclic compounds as immunomodulators
    Incyte
    03/20/23
  584. 2
    Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)
    Forma Therapeutics
    03/20/23
  585. 39
    5-heteroaryl-1H-pyrazol-3-amine derivative
    Sumitomo Pharma
    03/19/23
  586. 158
    5-membered heteroaryl carboxamide compounds for treatment of HBV
    Assembly Biosciences
    03/19/23
  587. 145
    Amino acid compounds and methods of use
    Pliant Therapeutics
    03/19/23
  588. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    03/19/23
  589. 17
    Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
    Board Of Regents, The University Of Texas System
    03/19/23
  590. 158
    Cannabinoid receptor type 2 (CB2) modulators and uses thereof
    Teon Therapeutics
    03/19/23
  591. 50
    Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists
    Trustees Of Tufts College
    03/19/23
  592. 478
    Compounds and uses thereof
    Foghorn Therapeutics
    03/19/23
  593. 4
    Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
    Alternox Scientific
    03/19/23
  594. 62
    Fused amino pyridine as HSP90 inhibitors
    Guris
    03/19/23
  595. 377
    Indole compounds and analogues thereof
    Biocryst Pharmaceuticals
    03/19/23
  596. 373
    Isoquinolines as inhibitors of HPK1
    Genentech
    03/19/23
  597. 17
    Morpholinylpyridone compounds
    Sprint Bioscience
    03/19/23
  598. 175
    Proteasome activity enhancing compounds
    Proteostasis Therapeutics
    03/19/23
  599. 22
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    03/19/23
  600. 718
    Ras inhibitors
    Revolution Medicines
    03/19/23
  601. 149
    Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors
    Pfizer
    03/19/23
  602. 17
    2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    03/12/23
  603. 474
    ACLY inhibitors and uses thereof
    Nimbus Artemis
    03/12/23
  604. 98
    Amide compounds as kinase inhibitors, compositions and methods of treatment
    Translational Drug Development
    03/12/23
  605. 215
    Bruton's tyrosine kinase inhibitors
    Suzhou Baijibugong Pharmaceutical Technology
    03/12/23
  606. 656
    PD-1/PD-L1 inhibitors
    Gilead Sciences
    03/12/23
  607. 22
    Phosphonate linkers and their use to facilitate cellular retention of compounds
    Merck Sharp & Dohme
    03/12/23
  608. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    The Usa, As Represented By The Secretary, Dhhs
    03/12/23
  609. 46
    Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
    Amgen
    03/06/23
  610. 21
    Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
    Jazz Pharmaceuticals Ireland
    03/06/23
  611. 109
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology
    03/06/23
  612. 137
    Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
    Beijing Scitech-Mq Pharmaceuticals
    03/06/23
  613. 23
    Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
    Gilead Sciences
    03/06/23
  614. 581
    Transglutaminase 2 (TG2) inhibitors
    Sitari Pharma
    03/06/23
  615. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    Legochem Biosciences
    03/05/23
  616. 822
    HPK1 antagonists and uses thereof
    Nimbus Saturn
    03/05/23
  617. 523
    Heterocyclic compounds and uses thereof
    Millennium Pharmaceuticals
    03/05/23
  618. 238
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Biosplice Therapeutics
    03/05/23
  619. 45
    Kinase inhibitor compounds and compositions and methods of use
    Icahn School Of Medicine At Mount Sinai
    03/05/23
  620. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals
    03/05/23
  621. 59
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    03/05/23
  622. 13
    Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1
    Mangosuthu University Of Technology
    03/05/23
  623. 31
    Therapeutic compounds and methods of use thereof
    Ligature Therapeutics
    03/05/23
  624. 5
    Amide compound having bet proteolysis-inducing action and medicinal application thereof
    Mitsubishi Tanabe Pharma
    02/26/23
  625. 47
    BTK inhibitor compounds
    Eli Lilly
    02/26/23
  626. 10
    Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
    Janssen Pharmaceutica
    02/26/23
  627. 230
    Compositions and methods for treating CNS disorders
    Sage Therapeutics
    02/26/23
  628. 6
    Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
    Sarbonne Universite
    02/26/23
  629. 65
    Compounds for the treatment of kinase-dependent disorders
    Exelixis
    02/26/23
  630. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
    Shy Therapeutics
    02/26/23
  631. 108
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    02/26/23
  632. 6
    IRAK degraders and uses thereof
    Dana-Farber Cancer Institute
    02/26/23
  633. 27
    Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
    Universisity Of Utah Research Foundation
    02/26/23
  634. 42
    Phenothiazine derivatives and uses thereof
    Camp4 Therapeutics
    02/26/23
  635. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte
    02/26/23
  636. 5
    Quinoline compounds as IRAK inhibitors and uses thereof
    Merck Patent
    02/26/23
  637. 17
    STK19 inhibitors for treatment of cancer
    Trustees Of Boston University
    02/26/23
  638. 46
    Sting modulator compounds, and methods of making and using
    Takeda Pharmaceutical
    02/26/23
  639. 51
    Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
    Children's Hospital Medical Center
    02/26/23
  640. 96
    Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
    Aurigene Discovery Technologies
    02/26/23
  641. 71
    Substituted piperazines as selective HDAC1,2 inhibitors
    Regenacy Pharmaceuticals
    02/26/23
  642. 1
    Substituted piperidines as BTK inhibitors
    Haisco Pharmaceuticals
    02/26/23
  643. 8
    Synthesis of peptide borate ester compound and use thereof
    Jiangsu Chia Tai Fenghai Pharmaceutical
    02/26/23
  644. 5
    Tetrahydroisoquinoline derivatives, preparation process and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical
    02/26/23
  645. 94
    Therapeutic compounds and methods of use thereof
    Agency For Science, Technology And Research (A*Star
    02/26/23
  646. 16
    Analogs of dextromethorphan with balanced receptor activities
    Center For Neurologic Study
    02/20/23
  647. 11
    Benzisoxazole derivative
    Sumitomo Pharma
    02/20/23
  648. 155
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    02/20/23
  649. 15
    Dioxoloisoquinolinone derivatives and use thereof
    Hanmi Pharmaceutical
    02/20/23
  650. 287
    Heterobicyclic amides as inhibitors of CD38
    Ribon Therapeutics
    02/20/23
  651. 21
    Heterocyclic compounds as immunomodulators
    Incyte
    02/20/23
  652. 26
    Histone deacetylases (HDACs) inhibitors
    Annji Pharmaceutical
    02/20/23
  653. 100
    Isoindolines as HDAC inhibitors
    Valo Health
    02/20/23
  654. 198
    MAP4K1 inhibitors
    Blueprint Medicines
    02/20/23
  655. 39
    Methods for treating depressive symptoms
    Alkermes Pharma Ireland
    02/20/23
  656. 85
    Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
    H. Lundbeck
    02/20/23
  657. 10
    Pyrrolo[1,2-b] pyridazine derivatives
    Gilead Sciences
    02/20/23
  658. 75
    Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof
    Institute Of Materia Medica, Chinese Academy Of Medical Sciences
    02/20/23
  659. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Holdings
    02/17/23
  660. 228
    Compositions and methods for treating CNS disorders
    Sage Therapeutics
    02/17/23
  661. 59
    Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
    Nurix Therapeutics
    02/17/23
  662. 382
    Cyclic polypeptides for PCSK9 inhibition
    Merck Sharp & Dohme
    02/17/23
  663. 3
    Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
    Genzyme
    02/17/23
  664. 17
    Ligands to cereblon (CRBN)
    Dana-Farber Cancer Institute
    02/17/23
  665. 93
    Naphthyridinone derivatives and their use in the treatment of arrhythmia
    Novartis
    02/17/23
  666. 16
    Small molecule inhibition of transcription factor SALL4 and uses thereof
    Dana-Farber Cancer Institute
    02/17/23
  667. 291
    Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
    Janssen Pharmaceutica
    02/17/23
  668. 9
    Use of known compounds as D-amino acid oxidase inhibitors
    National Taiwan University
    02/17/23
  669. 431
    2-(morpholin-4-yl)-1,7-naphthyridines
    Bayer Pharma Aktiengesellschaft
    02/16/23
  670. 30
    Alpha-5 beta-1 inhibitors
    The Regents Of The University Of California
    02/16/23
  671. 45
    Analogs for the treatment of disease
    Insilico Medicine Ip
    02/16/23
  672. 45
    Analogs for the treatment of disease
    Insilico Medicine Ip
    02/16/23
  673. 63
    Compositions and methods for treating infections
    Vyera Pharmaceuticals
    02/16/23
  674. 31
    Compounds
    Inflazome
    02/16/23
  675. 9
    Imidazo[4,5-C]pyridine derived SSAO inhibitors
    Proximagen
    02/16/23
  676. 123
    Kinase inhibitors
    The University Of Manchester
    02/16/23
  677. 31
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb
    02/16/23
  678. 17
    Protacs targeting coronavirus 3CL protease and preparation method and application thereof
    Shaanxi Panlong Pharmaceutical
    02/16/23
  679. 51
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics
    02/16/23
  680. 61
    Use of aminomethylenecyclohexane-1,3-dione compound
    Wigen Biomedicine Technology (Shanghai)
    02/16/23
  681. 717
    Heterocyclic compound as a protein kinase inhibitor
    Hk Inno.N
    02/13/23
  682. 14
    JAK kinase inhibitor and preparation method and use thereof
    Shanghai Longwood Biopharmaceuticals
    02/13/23
  683. 31
    Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
    Prelude Therapeutics
    02/13/23
  684. 7
    Alkyne substituted quinazoline compound and methods of use
    Newgen Therapeutics
    02/12/23
  685. 10
    Compounds for treating ILK-mediated diseases
    The Cleveland Clinic Foundation
    02/12/23
  686. 1076
    Indole and azaindole inhibitors of pad enzymes
    Bristol-Myers Squibb
    02/12/23
  687. 310
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences
    02/12/23
  688. 7
    Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
    Vtv Therapeutics
    02/12/23
  689. 15
    Pyrazole compounds as LSD1 inhibitors and applications thereof
    Medshine Discovery
    02/12/23
  690. 58
    CDPK1 inhibitors, compositions, and methods related thereto
    Vyera Pharmaceuticals
    02/05/23
  691. 11
    Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Kronos Bio
    02/05/23
  692. 50
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Nikang Therapeutics
    02/05/23
  693. 8
    Inhibitors of DNMT1 as anticancer therapeutic agents
    Victoria Link
    02/05/23
  694. 15
    MTOR inhibitor compounds
    Galderma Research & Development
    02/05/23
  695. 2
    Macrocycle and composition comprising thereof
    Shenzhen Targetrx
    02/05/23
  696. 9
    Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof
    Shaanxi Panlong Pharmaceutical
    02/05/23
  697. 10
    Radiolabeled pharmaceuticals and methods of making and using same
    Yale University
    02/05/23
  698. 370
    Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
    Ontario Institute For Cancer Research (Oicr
    02/05/23
  699. 59
    Compounds useful in HIV therapy
    Glaxosmithkline Intellectual Property Development
    01/31/23
  700. 50
    Aminocyclobutanes as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    01/28/23
  701. 250
    Anti-tumor effect potentiator using novel biphenyl compound
    Taiho Pharmaceutical
    01/28/23
  702. 16
    BRK inhibitory compound
    Ono Pharmaceutical
    01/28/23
  703. 102
    CRBN ligands and uses thereof
    Kymera Therapeutics
    01/28/23
  704. 139
    Compounds and methods for the enhanced degradation of targeted proteins
    Arvinas Operations
    01/28/23
  705. 1
    Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
    Shenzhen Targetrx
    01/28/23
  706. 107
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
    Takeda Pharmaceutical
    01/28/23
  707. 35
    2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy
    Thomas Helledays Stiftelse FÖR Medicinsk Forskning
    01/21/23
  708. 3
    Aryl-piperidine derivatives
    Artax Biopharma
    01/21/23
  709. 76
    Azaspirocycles as monoacylglycerol lipase modulators
    Janssen Pharmaceutica
    01/21/23
  710. 159
    Compounds and methods for treating oxalate-related diseases
    Oxalurx
    01/21/23
  711. 138
    Dihydroorotate dehydrogenase inhibitors
    Janssen Biotech
    01/21/23
  712. 19
    HDAC8 inhibitors for treating cancer
    City Of Hope
    01/21/23
  713. 62
    Inhibitors of fibroblast activation protein
    Praxis Biotech
    01/21/23
  714. 81
    SSAO inhibitor
    Shandong Danhong Pharmaceutical
    01/21/23
  715. 3
    Tetrahydroquinoline derivatives and a process of preparation thereof
    King Abdulaziz University
    01/21/23
  716. 30
    Therapeutic compounds and methods of use thereof
    Ligature Therapeutics
    01/21/23
  717. 196
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck
    01/20/23
  718. 150
    ACLY inhibitors and uses thereof
    Nimbus Artemis
    01/20/23
  719. 45
    Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
    Janssen Sciences Ireland
    01/20/23
  720. 120
    Benzisoxazole sulfonamide derivatives
    Pfizer
    01/20/23
  721. 23
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    01/20/23
  722. 24
    Cyclic peptide immunomodulators
    Bristol-Myers Squibb
    01/20/23
  723. 54
    Indazole compounds and uses thereof
    Incyte
    01/20/23
  724. 320
    MTA-cooperative PRMT5 inhibitors
    Mirati Therapeutics
    01/20/23
  725. 66
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences
    01/20/23
  726. 7
    Peptides for treatment of medical disorders
    Humanwell Pharmaceutical Us
    01/20/23
  727. 4
    Therapeutic methods and combinations
    Individual
    01/20/23
  728. 2
    Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase
    Hanmi Pharm.
    01/20/23
  729. 153
    Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
    Neuropore Therapies
    01/20/23
  730. 26
    Azaindolylpyridone and diazaindolylpyridone compounds
    Sprint Bioscience
    01/17/23
  731. 38
    Dopamine D2 receptor ligands
    The Broad Institute
    01/17/23
  732. 152
    Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
    Blueray Therapeutics (Shanghai)
    01/17/23
  733. 275
    Tricyclic heterocycles as BET protein inhibitors
    Incyte
    01/17/23
  734. 368
    Amido spirocyclic amide and sulfonamide derivatives
    Valo Health
    01/06/23
  735. 137
    Compounds and methods useful in the treatment of a PRMT5-mediated disorder
    Argonaut Therapeutics
    01/06/23
  736. 140
    Compounds for inhibiting TNIK and medical uses thereof
    Korea Research Institute Of Chemical Technology
    01/06/23
  737. 127
    Compounds for treatment of PD-L1 diseases
    Chemocentryx
    01/06/23
  738. 2
    Deuterated compounds as rock inhibitors
    Fochon Pharmaceuticals
    01/06/23
  739. 82
    Mu opioid receptor modulators
    The Regents Of The University Of California
    01/06/23
  740. 35
    N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
    Boehringer Ingelheim International
    01/06/23
  741. 222
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    Mirati Therapeutics
    01/06/23
  742. 121
    Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
    Ksq Therapeutics
    01/06/23
  743. 5
    Synthesis of (+)-cannabinoids and their therapeutic effects
    Symrise
    01/06/23
  744. 222
    2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
    Hutchison Medipharma
    12/30/22
  745. 66
    5-5 fused rings as C5a inhibitors
    Chemocentryx
    12/30/22
  746. 6
    5-aminolevulinate synthase inhibitors and methods of use thereof
    University Of South Florida
    12/30/22
  747. 486
    Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
    Chemocentryx
    12/30/22
  748. 38
    EP4 antagonist
    Ono Pharmaceutical
    12/30/22
  749. 49
    Heterocyclic RIP1 kinase inhibitors
    Rigel Pharmaceuticals
    12/30/22
  750. 71
    Inhibitors of Rho associated coiled-coil containing protein kinase
    Kadmon
    12/30/22
  751. 321
    MTA-cooperative PRMT5 inhibitors
    Mirati Therapeutics
    12/30/22
  752. 70
    Macrocyclic chlorine substituted indole derivatives
    Bayer Aktiengesellschaft
    12/30/22
  753. 6
    Method for treating inflammation
    King Faisal University
    12/30/22
  754. 225
    OX2R compounds
    University Of Texas System
    12/30/22
  755. 14
    Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
    The Johns Hopkins University
    12/30/22
  756. 154
    Small molecule modulators of the BTB domain of Keap1
    Medimmune
    12/30/22
  757. 4
    Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
    Newave Pharmaceutical
    12/30/22
  758. 4
    Substituted piperidine compounds and their use
    Eisai R&D Management
    12/30/22
  759. 5
    Targeted drug rescue with novel compositions, combinations, and methods thereof
    Exciva
    12/30/22
  760. 24
    Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb
    12/30/22
  761. 94
    Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
    Beijing Scitech-Mq Pharmaceuticals
    12/30/22
  762. 35
    1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
    Southern Medical University
    12/24/22
  763. 27
    1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
    Angelini Acraf
    12/24/22
  764. 52
    Acyclic antivirals
    Janssen Pharmaceutica
    12/24/22
  765. 14
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    12/24/22
  766. 111
    Imidazopyrazinones as PDE1 inhibitors
    H. Lundbeck
    12/24/22
  767. 67
    Inhibitors of blood coagulation factor XIII
    Zedira
    12/24/22
  768. 172
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences
    12/24/22
  769. 1
    Mcl-1 inhibitors and methods of use thereof
    Astrazeneca
    12/24/22
  770. 37
    Pyrazolo[1,5-a]pyrazin-4-yl derivatives
    Pfizer
    12/24/22
  771. 186
    Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
    Beigene
    12/24/22
  772. 79
    Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    12/24/22
  773. 95
    Tricyclic compounds and their use as phosphodiesterase inhibitors
    Pfizer
    12/24/22
  774. 35
    Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
    Beigene
    12/23/22
  775. 11
    Compounds for treatment of hypoproliferative disorders
    Lu License
    12/23/22
  776. 27
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer
    12/23/22
  777. 5
    Docosahexaenoic acid endocannabinoid epoxide derivative compositions
    The Board Of Trustees Of The University Of Illinois
    12/23/22
  778. 279
    Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
    Incyte
    12/23/22
  779. 18
    Quinazolinones that inhibit the formation of tau oligomers and their method of use
    Oligomerix
    12/23/22
  780. 93
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    12/23/22
  781. 146
    SSAO inhibitors and use thereof
    Eccogene (Shanghai)
    12/23/22
  782. 19
    Sphingosine analogs and use thereof against bacterial lung infections
    Yeda Research And Development
    12/23/22
  783. 51
    3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
    Nurix Therapeutics
    12/11/22
  784. 69
    Compound functioning as bromodomain protein inhibitor, and composition
    Betta Pharmaceuticals
    12/11/22
  785. 48
    Compound having ERK kinase inhibitory activity and use thereof
    Shanghai Haihe Pharmaceutical
    12/11/22
  786. 10
    Cyclic di-nucleotide compounds as sting agonists
    Merck Sharp & Dohme
    12/11/22
  787. 13
    Heterocyclic compounds as immunomodulators
    Incyte
    12/11/22
  788. 94
    Heterocyclic inhibitors of PTPN11
    Board Of Regents, The University Of Texas System
    12/11/22
  789. 16
    Modulators of the NMDA receptor
    H. Lundbeck
    12/11/22
  790. 60
    Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
    Shanghai Yingli Pharmaceutical
    12/11/22
  791. 142
    Pharmaceutical compounds
    Otsuka Pharmaceutical
    12/11/22
  792. 31
    Pyridazines
    Boehringer Ingelheim International
    12/11/22
  793. 187
    Substituted lactams showing serotonin 5-HT receptor activity
    Sumitomo Pharma
    12/11/22
  794. 21
    Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
    Enanta Pharmaceuticals
    12/11/22
  795. 27
    Tricyclic compounds
    Jacobio Pharmaceuticals
    12/11/22
  796. 15
    2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
    The Trustees Of The University Of Pennsylvania
    12/07/22
  797. 286
    6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors
    Novartis
    12/07/22
  798. 20
    Annulated glycosidase inhibitors
    Asceneuron
    12/07/22
  799. 30
    Antibacterial compounds
    Infex Therapeutics
    12/07/22
  800. 140
    Biaryl derivative, preparation method thereof and pharmaceutical application thereof
    Abbisko Therapeutics
    12/07/22
  801. 72
    Broad spectrum antiviral compositions and methods
    Evrys Bio
    12/07/22
  802. 74
    Broad spectrum inhibitors of filoviruses
    Microbiotix
    12/07/22
  803. 3
    Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors
    Suven Life Sciences
    12/07/22
  804. 3
    Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
    Pharmakea
    12/07/22
  805. 108
    Heterocyclic compounds for the inhibition of PASK
    Bioenergenix
    12/07/22
  806. 71
    Imidazopyridazine and imidazopyridine compounds and uses thereof
    Incyte
    12/07/22
  807. 48
    Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    12/07/22
  808. 227
    Modulators of methyl modifying enzymes, compositions and uses thereof
    Constellation Pharmaceuticals
    12/07/22
  809. 160
    N/O-linked Degrons and Degronimers for protein degradation
    C4 Therapeutics
    12/07/22
  810. 67
    Pyrazine carbamates and their use as GluN2B receptor modulators
    Janssen Pharmaceutica
    12/07/22
  811. 5
    Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors
    Vimalan Biosciences
    12/07/22
  812. 229
    TEAD inhibitors and uses thereof
    Ikena Oncology
    12/07/22
  813. 36
    Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
    Nikang Therapeutics
    12/07/22
  814. 15
    3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    12/04/22
  815. 215
    Cyclic di-nucleotide compounds as sting agonists
    Merck Sharp & Dohme
    12/04/22
  816. 25
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D Ip
    12/04/22
  817. 452
    KRas G12D inhibitors
    Mirati Therapeutics
    12/04/22
  818. 143
    Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
    Beijing Tide Pharmaceutical
    12/04/22
  819. 576
    Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
    Sanford Burnham Prebys Medical Discovery Institute
    12/04/22
  820. 16
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
    Eli Lilly
    12/04/22
  821. 72
    Substituted eneoxindoles and uses thereof
    Gilead Sciences
    12/04/22
  822. 44
    Substituted propanamides as inhibitors of nucleases
    Masarykova Univerzita
    12/04/22
  823. 1
    Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors
    Shenzhen Targetrx
    12/04/22
  824. 29
    Tricyclic compounds useful to treat orthomyxovirus infections
    Novartis
    12/04/22
  825. 4
    (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
    Histogen
    11/20/22
  826. 66
    Galactoside inhibitor of galectins
    Galecto Biotech
    11/20/22
  827. 49
    Macrocyclic chlorine substituted indole derivatives
    Bayer Aktiengesellschaft
    11/20/22
  828. 225
    Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
    Cancer Research Technology
    11/20/22
  829. 12
    Tricyclic amine compounds as CDK2 inhibitors
    Incyte
    11/20/22
  830. 360
    Aminoimidazopyridazines as kinase inhibitors
    Bristol-Myers Squibb
    11/19/22
  831. 116
    Anti-inflammatory compound, and preparation and use thereof
    E-Nitiate Biopharmaceuticals (Hangzhou)
    11/19/22
  832. 25
    Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
    Shanghai Yingli Pharmaceutical
    11/19/22
  833. 83
    Compound exhibiting enteropeptidase inhibitory activity
    Lg Chem
    11/19/22
  834. 90
    Compounds, salts thereof and methods for treatment of diseases
    Acadia Pharmaceuticals
    11/19/22
  835. 64
    Cyclic compound having dopamine D3 receptor antagonistic effect
    Shionogi
    11/19/22
  836. 10
    Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof
    Korea Research Institute Of Chemical Technology
    11/19/22
  837. 32
    Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
    Recordati Industria Chimica E Farmacentica
    11/19/22
  838. 33
    Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof
    Hinova Pharmaceuticals
    11/19/22
  839. 95
    Inhibitors of cyclin-dependent kinases
    Kinnate Biopharma
    11/19/22
  840. 118
    Pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    11/19/22
  841. 46
    Pyrimidine JAK inhibitors for the treatment of skin diseases
    Theravance Biopharma R&D Ip
    11/19/22
  842. 98
    Pyrimidine TBK/IKKe inhibitor compounds and uses thereof
    Merck Patent
    11/19/22
  843. 7
    Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
    Nanjing Zhengxiang Pharmaceuticals
    11/19/22
  844. 5
    Selective A2A receptor antagonist
    Inxmed (Nanjing)
    11/19/22
  845. 94
    Spiroheptanyl hydantoins as rock inhibitors
    Bristol-Myers Squibb
    11/19/22
  846. 6
    Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity
    The Board Of Trustees Of The Leland Stanford Junior University
    11/19/22
  847. 79
    Substituted macrocyclic indole derivatives
    Bayer Aktiengesellschaft
    11/19/22
  848. 30
    Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
    Milstein Zhang & Wu
    11/19/22
  849. 353
    Tetrahydroquinoline derivatives as P2X7 receptor antagonists
    Raqualia Pharma
    11/19/22
  850. 22
    Triazolo-azepine derivatives
    Hoffmann-La Roche
    11/19/22
  851. 32
    Tricyclic amine compounds as CDK2 inhibitors
    Incyte
    11/19/22
  852. 10
    p38α mitogen-activated protein kinase inhibitors
    Gen1E Lifesciences
    11/19/22
  853. 12
    ASK1 inhibitor compounds and uses thereof
    Seal Rock Therapeutics
    11/13/22
  854. 56
    ATR inhibitor and application thereof
    Wuxi Biocity Biopharmaceutics
    11/13/22
  855. 129
    Heterocyclic inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    11/13/22
  856. 359
    Heterocyclylamines as PI3K inhibitors
    Incyte
    11/13/22
  857. 164
    LSD1 inhibitor and preparation method and application thereof
    Medshine Discovery
    11/13/22
  858. 70
    PDE9 inhibitor and use thereof
    Nanjing Transthera Biosciences
    11/13/22
  859. 17
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech
    11/13/22
  860. 166
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    11/13/22
  861. 70
    Aryl cyclopropyl-amino-isoquinolinyl amide compounds
    Aerie Pharmaceuticals
    11/07/22
  862. 69
    Bromodomain inhibitor compound and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    11/07/22
  863. 124
    Composition and methods for inhibiting mammalian sterile 20-like kinase 1
    The Scripps Research Institute
    11/07/22
  864. 8
    Cycloalkyl-diamines for the treatment of inflammation
    Medisynergics
    11/07/22
  865. 291
    Dihydrooxadiazinones
    Bayer Aktiengesellschaft
    11/07/22
  866. 40
    IRAK4 inhibiting agents
    Biogen Ma
    11/07/22
  867. 84
    Imidazo-pyridine compounds as PAD inhibitors
    Jubilant Epipad
    11/07/22
  868. 465
    Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
    Incyte
    11/07/22
  869. 312
    Immunomodulator compounds
    Chemocentryx
    11/07/22
  870. 332
    Indazoles and azaindazoles as LRRK2 inhibitors
    Escape Bio
    11/07/22
  871. 543
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica
    11/07/22
  872. 22
    JAK inhibitor and use thereof
    Zhuhai United Laboratories
    11/07/22
  873. 13
    Kinase inhibitors
    Insilico Medicine Ip
    11/07/22
  874. 24
    Prolyl hydroxylase inhibitors and methods of use
    Akebia Therapeutics
    11/07/22
  875. 4
    Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
    Mindset Pharma
    11/07/22
  876. 84
    Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
    The Johns Hopkins University
    11/07/22
  877. 228
    Substituted pyrrolopyridine-derivatives
    Bayer Pharma Aktiengesellschaft
    11/07/22
  878. 1
    Substituted quinolines useful as kinase inhibitors
    Teligene
    11/07/22
  879. 22
    4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
    Nerviano Medical Sciences
    11/06/22
  880. 208
    Amide substituted indole compounds useful as TLR inhibitors
    Bristol-Myers Squibb
    11/06/22
  881. 29
    Arginase inhibitors and methods of use thereof
    Astrazeneca
    11/06/22
  882. 452
    Aryl and heteroaryl substituted indole compounds
    Bristol-Myers Squibb
    11/06/22
  883. 589
    Bcl-2 inhibitors
    Beigene
    11/06/22
  884. 150
    Bicyclic compounds
    Vivace Therapeutics
    11/06/22
  885. 18
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    Xwpharma
    11/06/22
  886. 26
    DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof
    Yunnan University
    11/06/22
  887. 145
    Dosage forms and regimens for amino acid compounds
    Pliant Therapeutics
    11/06/22
  888. 67
    Heterocyclic compounds as anti-viral agents
    Enanta Pharmaceuticals
    11/06/22
  889. 16
    Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
    Nikang Therapeutics
    11/06/22
  890. 316
    Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
    Novartis
    11/06/22
  891. 39
    Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors
    Transthera Sciences (Nanjing
    11/06/22
  892. 67
    Substituted pyrrolopyridines as JAK inhibitors
    Aclaris Therapeutics
    11/06/22
  893. 30
    Treatment of tachycardia
    Oslo University Hospital
    11/06/22
  894. 53
    AMPK activators
    Kallyope
    11/05/22
  895. 22
    Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
    Gwangju Institute Of Science And Technology
    11/05/22
  896. 149
    Compounds and uses thereof
    Foghorn Therapeutics
    10/30/22
  897. 78
    Compounds for the treatment of BRAF-associated diseases and disorders
    Array Biopharma
    10/30/22
  898. 5
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    10/30/22
  899. 97
    Formulations of Tie-2 activators and methods of use thereof
    Eyepoint Pharmaceuticals
    10/30/22
  900. 55
    Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals
    10/30/22
  901. 66
    Heterocyclic compounds as immunomodulators
    Incyte
    10/30/22
  902. 136
    Heterocyclic compounds as modulators of mGluR7
    Pragma Therapeutics
    10/30/22
  903. 212
    Inhibitors of protein kinases
    Alexion Pharmaceuticals
    10/30/22
  904. 19
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland Uniservices
    10/30/22
  905. 103
    Oxoacridinyl acetic acid derivatives and methods of use
    Stingthera
    10/30/22
  906. 379
    P300/CBP hat inhibitors
    Constellation Pharmaceuticals
    10/30/22
  907. 1022
    Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
    Nimbus Lakshmi
    10/30/22
  908. 37
    Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
    Mission Therapeutics
    10/30/22
  909. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute
    10/28/22
  910. 58
    Antibacterial compounds
    Forge Therapeutics
    10/28/22
  911. 121
    Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals
    10/28/22
  912. 80
    CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
    Amgen
    10/28/22
  913. 3
    Derivatives of an FGFR inhibitor
    Incyte
    10/28/22
  914. 36
    Dioxinoquinoline compounds, preparation method and uses thereof
    Beijing Scitech-Mq Pharmaceuticals
    10/28/22
  915. 114
    Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
    Development Center For Biotechnology
    10/28/22
  916. 27
    Heterocyclic compounds as immunomodulators
    Incyte
    10/28/22
  917. 85
    Inhibitors of RAF kinases
    Kinnate Biopharma
    10/28/22
  918. 26
    JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
    Incyte
    10/28/22
  919. 118
    Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
    Washington University
    10/28/22
  920. 16
    Pyrazolopyridine compounds and uses thereof
    Incyte
    10/28/22
  921. 208
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    10/28/22
  922. 13
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical
    10/28/22
  923. 13
    Treatment of upper aerodigestive tract disorders and cough
    Individual
    10/28/22
  924. 79
    Tropomyosin-related kinase (TRK) inhibitors
    Genzyme
    10/28/22
  925. 22
    1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    Novartis
    10/23/22
  926. 153
    Alcoxyamino derivatives for treating pain and pain related conditions
    Esteve Pharmaceuticals
    10/23/22
  927. 1
    Biochemical binding of RET9 and VEGFR2 inhibitors
    Kala Pharmaceuticals
    10/23/22
  928. 23
    Cyclic dinucleotide compound and uses thereof
    Shanghai Jemincare Pharmaceuticals
    10/23/22
  929. 64
    Dihydroquinolinones for medical treatment
    C4 Therapeutics
    10/23/22
  930. 307
    Heteroaryl inhibitors of PDE4
    Tetra Discovery Partners
    10/23/22
  931. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte
    10/23/22
  932. 11
    Isoquinoline derivatives and use thereof
    Purdue Pharma
    10/23/22
  933. 62
    Macrocyclic indole derivatives
    The Broad Institute
    10/23/22
  934. 40
    Pyrido[3,2-d]pyrimidine compounds as immunomodulators
    Incyte
    10/23/22
  935. 81
    Pyrimidinones as PI3K inhibitors
    Incyte Holdings
    10/23/22
  936. 41
    Small molecule activators of Parkin enzyme function
    Mayo Foundation For Medical Education And Research
    10/23/22
  937. 8
    [1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
    Eli Lilly
    10/23/22
  938. 23
    1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
    The Board Of Trustees Of The University Of Illinois
    10/17/22
  939. 34
    Amine compound for inhibiting SSAO/VAP-1 and use thereof
    Sunshine Lake Pharma
    10/17/22
  940. 15
    Amino acid compounds with unbranched linkers and methods of use
    Pliant Therapeutics
    10/17/22
  941. 21
    Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    10/17/22
  942. 479
    Benzodiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals
    10/17/22
  943. 218
    CDK2/4/6 inhibitors
    Pfizer
    10/17/22
  944. 45
    Substituted heterocyclic derivatives as PI3K inhibitors
    Incyte
    10/17/22
  945. 601
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    10/17/22
  946. 2
    Tricyclic compounds as Cyp1 inhibitors
    The General Hospital
    10/17/22
  947. 267
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics
    10/16/22
  948. 66
    Arginase inhibitors as therapeutics
    Mars
    10/16/22
  949. 104
    Compounds and methods for treating oxalate-related diseases
    Oxalurx
    10/16/22
  950. 34
    Compounds for targeting mutant huntingtin protein and uses thereof
    Chdi Foundation
    10/16/22
  951. 159
    Inhibitors of cyclin-dependent kinases
    Kinnate Biopharma
    10/16/22
  952. 7
    Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech
    10/16/22
  953. 215
    Piperazine derivatives as MAGL inhibitors
    Hoffmann-La Roche
    10/16/22
  954. 47
    Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
    Incyte
    10/16/22
  955. 314
    Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
    Beijing Tide Pharmaceutical
    10/16/22
  956. 38
    Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
    Guangzhou Maxinovel Pharmaceuticals
    10/09/22
  957. 1
    Diphenylaminopyrimidine compound for inhibiting kinase activity
    Shenzhen Targetrx
    10/09/22
  958. 20
    Heterocyclic compound as CSF-1R inhibitor and use thereof
    Medshine Discovery
    10/09/22
  959. 45
    Heterocyclic compounds useful as aurora a selective inhibitors
    Jacobio Pharmaceuticals
    10/09/22
  960. 120
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals
    10/09/22
  961. 7
    Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
    Union Therapeutics
    10/09/22
  962. 19
    Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
    Incyte
    10/09/22
  963. 209
    2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
    Merck Sharp & Dohme
    10/06/22
  964. 132
    CD73 inhibitors
    Oric Pharmaceuticals
    10/06/22
  965. 106
    Galactoside inhibitor of galectins
    Galecto Biotech
    10/06/22
  966. 164
    Heterocyclic prolinamide derivatives
    Orion Ophthalmology
    10/06/22
  967. 41
    Acetyl-CoA carboxylase modulators
    Monsanto Technology
    10/05/22
  968. 20
    Inhibiting mutant IDH-1
    Forma Therapeutics
    10/05/22
  969. 56
    Inhibitors of RAF kinases
    Kinnate Biopharma
    10/05/22
  970. 19
    Inhibitors of histone deacetylase
    The Broad Institute
    10/05/22
  971. 34
    Purine derivatives and the use thereof as medicament
    Boehringer Ingelheim International
    10/05/22
  972. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    10/05/22
  973. 177
    Serine/threonine kinase inhibitors
    Genentech
    10/05/22
  974. 32
    3-arylindazoles as selective MEK4 inhibitors
    Northwestern University
    09/25/22
  975. 10
    Antimalarial compounds, process for preparation and their use for drug resistant malaria
    Council Of Scientific And Industrial Research
    09/25/22
  976. 229
    Compounds
    Tmem16A
    09/25/22
  977. 23
    Compounds and methods for inhibiting CPY26 enzymes
    Queens University At Kingston
    09/25/22
  978. 54
    Compounds that inhibit Mcl-1 protein
    Amgen
    09/25/22
  979. 549
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    09/25/22
  980. 92
    Cyano-substituted heterocycles with activity as inhibitors of USP30
    Mission Therapeutics
    09/25/22
  981. 79
    FGFR inhibitor and application thereof
    Betta Pharmaceuticals
    09/25/22
  982. 598
    GLS1 inhibitors for treating disease
    Board Of Regents, The University Of Texas System
    09/25/22
  983. 21
    Heteroaryl plasma kallikrein inhibitors
    Takeda Pharmaceutical
    09/25/22
  984. 60
    Heterocyclic inhibitors of tyrosine kinase
    Board Of Regents, The University Of Texas System
    09/25/22
  985. 124
    Imidazolidin-2-one compounds as PRMT5 modulators
    Aurigene Discovery Technologies
    09/25/22
  986. 27
    Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
    Eli Lilly
    09/25/22
  987. 365
    Melt-extruded solid dispersions containing an apoptosis-inducing agent
    Abbvie
    09/25/22
  988. 10
    Optically active azabicyclo ring derivative
    Sumitomo Dainippon Pharma
    09/25/22
  989. 17
    P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof
    Shanghai Zhimeng Biopharma
    09/25/22
  990. 47
    Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer
    Pelemed
    09/25/22
  991. 5
    Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
    Imara
    09/25/22
  992. 447
    Pyridine compound substituted with azole
    Taisho Pharmaceutical
    09/25/22
  993. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    09/25/22
  994. 14
    Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    Epigenetix
    09/25/22
  995. 528
    Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
    Biocryst Pharmaceuticals
    09/25/22
  996. 185
    Substituted cyclohexyl compounds as NOP inhibiiors
    Dart Neuroscience
    09/25/22
  997. 73
    Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    Union Therapeutics
    09/25/22
  998. 62
    Substituted pyrazoles as LRRK2 inhibitors
    Oscotec
    09/25/22
  999. 7
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals
    09/25/22
  1000. 31
    CRBN ligands and uses thereof
    Kymera Therapeutics
    09/19/22
  1001. 9
    Compounds and methods for inhibiting CYP26 enzymes
    Queens University At Kingston
    09/19/22
  1002. 29
    Functionalized peptides as antiviral agents
    Enanta Pharmaceuticals
    09/19/22
  1003. 102
    Lysyl oxidase-like 2 inhibitors and uses thereof
    Pharmakea
    09/19/22
  1004. 12
    Prodrugs of modulators of the NMDA receptor
    H. Lundbeck
    09/19/22
  1005. 56
    Compounds useful as RET inhibitors
    Cancer Research Technology
    09/11/22
  1006. 122
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals
    09/11/22
  1007. 305
    TGF-beta inhibitors
    Syngene International
    09/11/22
  1008. 198
    1-cyano-pyrrolidine derivatives as DUB inhibitors
    Mission Therapeutics
    09/10/22
  1009. 261
    2,4-disubstituted pyrimidines useful as kinase inhibitors
    Celgene Car
    09/10/22
  1010. 163
    Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
    Jubilant Epicore
    09/10/22
  1011. 347
    HIV protease inhibitors
    Gilead Sciences
    09/10/22
  1012. 324
    Inhibitors of plasma kallikrein and uses thereof
    Takeda Pharmaceutical
    09/10/22
  1013. 89
    Nitrile-containing antiviral compounds
    Pfizer
    09/10/22
  1014. 210
    Phenoxymethyl derivatives
    Hoffmann-La Roche
    09/10/22
  1015. 281
    Pyridine and pyridimine compounds as PI3K-gamma inhibitors
    Incyte
    09/10/22
  1016. 33
    Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
    Xiamen University
    09/10/22
  1017. 16
    Substituted pyrimidines as CDK4/6 inhibitors
    Beijing Xuanyi Pharmasciences
    09/10/22
  1018. 241
    2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
    Beijing Scitech Mq Pharmaceuticals
    09/05/22
  1019. 33
    Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
    Pharmakea
    09/05/22
  1020. 152
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    09/05/22
  1021. 28
    Autotaxin inhibitor compounds
    Sabre Therapeutics
    09/05/22
  1022. 42
    Benzamide compounds
    Recurium Ip Holding
    09/05/22
  1023. 69
    Benzopyrazole compound used as RHO kinase inhibitor
    Medshine Discovery
    09/05/22
  1024. 280
    Inhibitors of fibroblast growth factor receptor kinases
    Kinnate Biopharma
    09/05/22
  1025. 9
    KRAS mutant protein inhibitors
    Jacobio Pharmaceuticals
    09/05/22
  1026. 137
    Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
    Shionogi
    09/05/22
  1027. 43
    PGDH inhibitors and methods of making and using
    Myoforte Therapeutics
    09/05/22
  1028. 128
    Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
    Janssen Pharmaceutica
    09/05/22
  1029. 20
    Quaternary lactam compound and pharmaceutical use thereof
    Shanghai Meiyue Biotech Development
    09/05/22
  1030. 64
    Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
    Guangzhou Innocare Pharma Tech
    09/05/22
  1031. 2
    Substituted pyrazolopyrimidines useful as kinases inhibitors
    Teligene
    09/05/22
  1032. 31
    4H-pyrrolo[3,2-c]pyridin-4-one derivatives
    Bayer Aktiengesellschaft
    08/29/22
  1033. 75
    Aliphatic acid amide derivative
    Sumitomo Dainippon Pharma
    08/29/22
  1034. 35
    Glycoside derivatives and uses thereof
    Novartis
    08/29/22
  1035. 52
    Imidazole and triazole containing bicyclic compounds as JAK inhibitors
    Theravance Biopharma R&D Ip
    08/29/22
  1036. 55
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals
    08/29/22
  1037. 33
    Substituted piperidines as kinase inhibitors
    Daewoong Pharmaceutical
    08/29/22
  1038. 207
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    08/28/22
  1039. 34
    Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    08/28/22
  1040. 466
    Heteroaryl Rheb inhibitors and uses thereof
    Navitor Pharmaceuticals
    08/28/22
  1041. 266
    Heterocyclic compounds as immunomodulators
    Incyte
    08/28/22
  1042. 34
    Identification of stabilizers of multimeric proteins
    Leland Stanford Junior University
    08/28/22
  1043. 28
    Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
    Bayer Aktiengesellschaft
    08/28/22
  1044. 11
    hTRPV1 chemical agents
    University Of Pittsburgh
    08/28/22
  1045. 12
    CD73 inhibitors and therapeutic uses thereof
    Jiangsu Hengrui Medicine
    08/21/22
  1046. 22
    Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
    Korea Institute Of Science And Technology
    08/21/22
  1047. 33
    Inhibitors of lysine gingipain
    Cortexyme
    08/21/22
  1048. 42
    MAGL inhibitors
    H. Lundbeck
    08/21/22
  1049. 94
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    08/21/22
  1050. 30
    Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
    Nuvation Bio
    08/21/22
  1051. 19
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    08/15/22
  1052. 203
    CD73 inhibitors
    Oric Pharmaceuticals
    08/15/22
  1053. 26
    CaMKII inhibitors and uses thereof
    The Johns Hopkins University
    08/15/22
  1054. 32
    Chemical compounds
    Astrazeneca
    08/15/22
  1055. 68
    Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
    The Governors Of The University Of Alberta
    08/15/22
  1056. 18
    Optically active crosslinked cyclic secondary amine derivative
    Sumitomo Dainippon Pharma
    08/15/22
  1057. 134
    Spiropyrrolidine derived antiviral agents
    Enanta Pharmaceuticals
    08/15/22
  1058. 22
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    Valo Health
    08/15/22
  1059. 26
    Combination therapy for treatment of hematological diseases
    Incyte
    08/14/22
  1060. 67
    Ketone inhibitors of lysine gingipain
    Cortexyme
    08/14/22
  1061. 42
    Benzamide compounds
    Recurium Ip Holdings
    08/07/22
  1062. 147
    Cyanopyrrolidines as dub inhibitors for the treatment of cancer
    Mission Therapeutics
    08/07/22
  1063. 415
    Inhibitors of Bruton's tyrosine kinase and methods of their use
    Janssen Pharmaceutica
    08/07/22
  1064. 22
    Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
    Temple University
    08/07/22
  1065. 121
    Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    08/07/22
  1066. 708
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics
    08/07/22
  1067. 18
    Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer
    Jubilant Biosys
    08/07/22
  1068. 173
    9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
    Merck Sharp & Dohme
    08/06/22
  1069. 61
    9H-pyrrolo-dipyridine derivatives
    Ucb Biopharma
    08/06/22
  1070. 410
    Azabenzimidazoles and their use as AMPA receptor modulators
    Janssen Pharmaceutica
    08/06/22
  1071. 17
    Ghrelin O-acyltransferase inhibitors
    Glaxosmithkline Intellectual Property Development
    08/06/22
  1072. 46
    Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
    Jiangsu Hengrui Medicine
    08/06/22
  1073. 113
    Hsp90 inhibitors and uses thereof
    Trustees Of Boston University
    08/06/22
  1074. 91
    Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors
    Pfizer
    08/06/22
  1075. 20
    Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
    Forma Therapeutics
    08/06/22
  1076. 177
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences
    08/06/22
  1077. 375
    Macrocyclic flu endonuclease inhibitors
    Janssen Biopharma
    08/06/22
  1078. 19
    Morpholine derivative
    Hoffmann-La Roche
    08/06/22
  1079. 83
    Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
    Merck Sharp & Dohme
    08/06/22
  1080. 6
    Protease inhibitors
    Medivir
    08/06/22
  1081. 182
    Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
    The Rockefeller University
    08/06/22
  1082. 63
    Pyrazole compound
    Sumitomo Dainippon Pharma
    08/06/22
  1083. 193
    Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
    Bayer Pharma Aktiengesellschaft
    08/06/22
  1084. 37
    Thienodiazepine derivatives and application thereof
    Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
    08/06/22
  1085. 54
    Treatment of GVHD
    Kadmon
    08/06/22
  1086. 78
    4,6 dihydropyrrolo [3,4-C] pyrazole-5 (1H)-carbonitrile derivates for treating cancer
    Mission Therapeutics
    08/01/22
  1087. 25
    Cyano thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute
    08/01/22
  1088. 23
    Inhibitors of KRAS G12C and methods of using the same
    Amgen
    08/01/22
  1089. 47
    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
    Venenum Biodesign
    08/01/22
  1090. 85
    3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
    Incyte
    07/31/22
  1091. 22
    Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
    Oligomerix
    07/31/22
  1092. 29
    Heterocyclic compounds as adenosine antagonists
    Nuvation Bio
    07/31/22
  1093. 176
    Phenylacetamides as inhibitors of rock
    Bristol-Myers Squibb
    07/31/22
  1094. 475
    Piperidine CXCR7 receptor modulators
    Idorsia Pharmaceuticals
    07/31/22
  1095. 52
    Substituted quinazolines for inhibiting kinase activity
    Neupharma
    07/31/22
  1096. 213
    Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors
    Boehringer Ingelheim International
    07/31/22
  1097. 26
    Treatment of hidradenitis suppurativa using JAK inhibitors
    Incyte
    07/31/22
  1098. 156
    2-arylsulfonamido-N-arylacetamide derivatized STAT3 inhibitors
    University Of Hawaii
    07/28/22
  1099. 83
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    07/24/22
  1100. 47
    Benzimidazole and indole compounds and uses thereof
    Incyte
    07/24/22
  1101. 10
    Chemical compounds
    Glaxosmithkline Intellectual Property (No. 2
    07/24/22
  1102. 66
    Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
    Bristol-Myers Squibb
    07/24/22
  1103. 108
    Heterocyclic compounds and uses thereof
    Nuvation Bio
    07/24/22
  1104. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    07/24/22
  1105. 24
    Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    Union Therapeutics
    07/24/22
  1106. 1
    Combination therapy involving diaryl macrocyclic compounds
    Turning Point Therapeutics
    07/21/22
  1107. 3
    Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same
    Medicare Pharmaceuticals
    07/21/22
  1108. 37
    Diarylhydantoin compounds and methods of use thereof
    Nuvation Bio
    07/21/22
  1109. 237
    Heterocyclic inhibitors of MCT4
    Vettore
    07/21/22
  1110. 18
    Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
    Hanmi Pharm.
    07/21/22
  1111. 184
    Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
    Reata Pharmaceuticals
    07/21/22
  1112. 171
    RAD51 inhibitors
    Cyteir Therapeutics
    07/21/22
  1113. 16
    Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
    Union Therapeutics
    07/21/22
  1114. 256
    Substituted piperidine compound and use thereof
    Takeda Pharmaceutical
    07/21/22
  1115. 781
    Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
    Forma Therapeutics
    07/21/22
  1116. 82
    Tricyclic CRBN ligands and uses thereof
    Kymera Therapeutics
    07/21/22
  1117. 32
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    Daegu-Gyeongbuk Medical Innovation Foundation
    07/16/22
  1118. 1775
    EIF4E-inhibiting compounds and methods
    Effector Therapeutics
    07/16/22
  1119. 33
    Macrocyclic fluorine substituted indole derivatives
    The Broad Institute
    07/16/22
  1120. 390
    Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
    Incyte
    07/16/22
  1121. 6
    Pyrrolidine compounds
    Eli Lilly
    07/16/22
  1122. 369
    Substituted piperazines as KRAS G12C inhibitors
    Amgen
    07/16/22
  1123. 9
    AMPK activators
    Kallyope
    07/10/22
  1124. 51
    Aromatic derivative, preparation method for same, and medical applications thereof
    Bioardis
    07/10/22
  1125. 19
    Compound as selective JAK inhibitor, and salt and therapeutic use thereof
    Suzhou Longbiotech Pharmaceuticals
    07/10/22
  1126. 435
    Compounds and compositions for the inhibition of NAMPT
    Valo Health
    07/10/22
  1127. 9
    Enantiomers of substituted thiazoles as antiviral compounds
    Innovative Molecules Gmbg
    07/10/22
  1128. 229
    Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
    Aptose Biosciences
    07/10/22
  1129. 41
    Inhibitors of RET
    Blueprint Medicines
    07/10/22
  1130. 61
    Macrocyclic compounds that inhibit MCL-1 protein
    Amgen
    07/10/22
  1131. 63
    Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
    Royal Institution For The Advancement Of Learning
    07/10/22
  1132. 171
    Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
    Amgen
    07/05/22
  1133. 291
    Colony stimulating factor-1 receptor (CSF-1R) inhibitors
    Genzyme
    07/05/22
  1134. 28
    Tricyclic compounds for use in treatment of proliferative disorders
    Argonaut Therapeutics
    07/05/22
  1135. 32
    Cyclopentane compounds
    Dizal (Jiangsu) Pharmaceutical
    07/04/22
  1136. 55
    MAPK inhibitors
    Everbrilliant Pharma
    07/04/22
  1137. 16
    Modulators of methyl modifying enzymes, compositions and uses thereof
    Constellation Pharmaceuticals
    07/04/22
  1138. 375
    P300/CBP HAT inhibitors
    Constellation Pharmaceuticals
    07/04/22
  1139. 34
    Pharmaceutical composition for ANO1 antagonist with anticancer activity
    Industry-Academic Cooperation Foundation Yonsei University
    07/04/22
  1140. 1
    Aminopyrimidine compound and composition comprising same and use thereof
    Shenzhen Targetrx
    06/26/22
  1141. 14
    Benzamide derivatives as PPAR-gamma modulators
    Medibiofarma
    06/26/22
  1142. 48
    Carbocyclic prolinamide derivatives
    Orion Ophthalmology
    06/26/22
  1143. 19
    Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
    Shanghai Ringene Biopharma
    06/26/22
  1144. 1
    Indazole compound for use in inhibiting kinase activity, composition and application thereof
    Shenzhen Targetrx
    06/26/22
  1145. 224
    Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
    Idorsia Pharmaceuticals
    06/26/22
  1146. 17
    Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
    King Abdulaziz University
    06/26/22
  1147. 105
    Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
    Array Biopharma
    06/26/22
  1148. 331
    Small molecule inhibitors of galectin-3
    Bristol-Myers Squibb
    06/26/22
  1149. 3
    Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
    Shionogi
    06/26/22
  1150. 516
    Triaryl compounds for treatment of PD-L1 diseases
    Chemocentryx
    06/26/22
  1151. 14
    Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
    Jubilant Biosys
    06/26/22
  1152. 73
    19-NOR neuroactive steroids and methods of use thereof
    Sage Therapeutics
    06/24/22
  1153. 15
    Aromatic compound, pharmaceutical composition and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical
    06/24/22
  1154. 587
    Biaryl derivative as GPR120 agonist
    Lg Chem.
    06/24/22
  1155. 53
    Bicyclic heterocyclic derivatives
    Merck Patent
    06/24/22
  1156. 48
    Dihydropyrimidine compounds and uses thereof in medicine
    Sunshine Lake Pharma
    06/24/22
  1157. 205
    Imidazotriaines and imidazopyrimidines as kinase inhibitors
    Incyte Holdings
    06/24/22
  1158. 51
    Sulfoximine glycosidase inhibitors
    Asceneuron
    06/24/22
  1159. 126
    TRPV4 antagonists
    Glaxosmithkline Intellectual Property (No. 2
    06/24/22
  1160. 41
    [1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International
    06/24/22
  1161. 9
    1,8-naphthyridinone compounds and uses thereof
    Nuvation Bio
    06/19/22
  1162. 637
    Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor
    Corvus Pharmaceuticals
    06/19/22
  1163. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D Ip
    06/19/22
  1164. 72
    Pyrazole derivative compound and use thereof
    Hanmi Pharm.
    06/19/22
  1165. 371
    Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
    Pfizer
    06/19/22
  1166. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics
    06/19/22
  1167. 45
    Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
    Children''S Hospital Medical Center
    06/19/22
  1168. 71
    3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
    Ludwig Institute For Cancer Research
    06/17/22
  1169. 22
    Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
    Tes Pharma
    06/17/22
  1170. 43
    N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
    Korea Research Institute Of Chemical Technology
    06/17/22
  1171. 409
    Substituted bicyclic compounds as farnesoid X receptor modulators
    Bristol-Myers Squibb
    06/17/22
  1172. 3
    Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist
    Suven Life Sciences
    06/17/22
  1173. 508
    Bicyclic fused pyridine compounds as inhibitors of TAM kinases
    Array Biopharma
    06/13/22
  1174. 114
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
    University Of Washington Through Its Center For Commercialization
    06/13/22
  1175. 69
    Compounds and methods for inhibiting JAK
    Dizal (Jiangsu) Pharmaceutical
    06/13/22
  1176. 116
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    06/13/22
  1177. 11
    FXR (NR1H4) modulating compounds
    Gilead Sciences
    06/13/22
  1178. 63
    Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
    Shanghai De Novo Pharmatech
    06/13/22
  1179. 4
    Metalloenzyme inhibitor compounds
    Mycovia Pharmaceuticals
    06/13/22
  1180. 288
    PCSK9 inhibitors and methods of use thereof
    Astrazeneca
    06/13/22
  1181. 157
    Phenyl indole allosteric inhibitors of P97 ATPase
    University Of Pittsburgh
    06/13/22
  1182. 3
    Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
    Oncobix
    06/13/22
  1183. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals
    06/13/22
  1184. 172
    Therapeutic compounds and uses thereof
    Genentech
    06/13/22
  1185. 52
    Tricyclic inhibitors of poly(ADP-ribose)polymerase
    Rakovina Therapeutics
    06/13/22
  1186. 510
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    The Trustees Of The University Of Pennsylvania
    06/12/22
  1187. 86
    (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
    Genentech
    06/10/22
  1188. 12
    2-phenyl-3,4-dihydropyrrolo[2,1-Ff] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
    Topadur Pharma
    06/10/22
  1189. 134
    Compounds useful for treating gastrointestinal tract disorders
    Ardelyx
    06/10/22
  1190. 2
    Ethynyl derivatives
    Hoffmann-La Roche
    06/10/22
  1191. 56
    Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    06/10/22
  1192. 174
    Proteasome activity enhancing compounds
    Proteostasis Therapeutics
    06/10/22
  1193. 76
    Pyrazolopyridine compounds and uses thereof
    Incyte
    06/10/22
  1194. 90
    Spirocyclic ROR-gamma modulators
    Escalier Biosciences
    06/10/22
  1195. 61
    Sulfonimidoylpurinone compounds and methods of treatment using the same
    Hoffmann-La Roche
    06/10/22
  1196. 98
    Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof
    Ontario Institute For Cancer Research (Oicr
    06/10/22
  1197. 6
    Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
    Landsteiner Genmed
    06/09/22
  1198. 1
    Formulations of an AXL/MER inhibitor
    Incyte
    06/09/22
  1199. 21
    Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2)
    Medibiofarma
    06/09/22
  1200. 95
    Inhibitors of plasma kallikrein
    Kalvista Pharmaceuticals
    06/09/22
  1201. 4
    Organosilicon carriers for use in treating infections and/or diseases caused by SARS viruses
    Individual
    06/09/22
  1202. 3
    Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
    Translational Drug Development
    06/06/22
  1203. 274
    Combination of isoindolinone derivatives with SGI-110
    Astex Therapeutics
    06/06/22
  1204. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    06/06/22
  1205. 99
    Fused ring compounds
    Genentech
    06/06/22
  1206. 134
    Isoxazole compounds as inhibitors of heat shock proteins
    Cancer Research Technology
    06/06/22
  1207. 197
    KIF18A inhibitors
    Amgen
    06/06/22
  1208. 8
    Morpholine derivates as inhibitors of Vps34
    Neuropore Therapies
    06/06/22
  1209. 77
    Protein kinase B inhibitors
    Astrazeneca
    06/06/22
  1210. 116
    Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
    Mission Therapeutics
    06/06/22
  1211. 183
    Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
    Genentech
    06/06/22
  1212. 6
    Substituted pyrrolopyridines as ATR inhibitors
    Bluevalley Pharmaceutical
    06/06/22
  1213. 36
    Substituted sulfoximine compounds
    Cadila Healthcare
    06/06/22
  1214. 11
    2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
    Crystalgenomics
    05/30/22
  1215. 166
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences
    05/30/22
  1216. 99
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme
    05/30/22
  1217. 244
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    05/29/22
  1218. 128
    Myocyte enhancer factor 2 (MEF2) modulators
    Standard
    05/29/22
  1219. 32
    Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    University Of Tennessee Research Foundation
    05/29/22
  1220. 38
    Substituted tetrahydroquinolinone compounds as ROR gamma modulators
    Aurigene Discovery Technologies
    05/29/22
  1221. 108
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
    Incyte
    05/29/22
  1222. 15
    Bicyclic inhibitors of histone deacetylase
    Alkermes
    05/22/22
  1223. 812
    Compounds that inhibits MCL-1 protein
    Amgen
    05/22/22
  1224. 18
    Heterocycles useful as anti-cancer agents
    Hangzhou Innogate Pharma
    05/22/22
  1225. 275
    Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
    Whitehead Institute For Biomedical Research
    05/22/22
  1226. 10
    Substituted pyridines as inhibitors of histone deacetylase
    Alkermes
    05/22/22
  1227. 122
    Tertiary alcohols as PI3K-γ inhibitors
    Incyte
    05/22/22
  1228. 16
    5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
    Temple University-Of The Commonwealth System Of Higher Education
    05/14/22
  1229. 137
    Cyclin dependent kinase inhibitors
    Pfizer
    05/14/22
  1230. 333
    Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
    La Jolla Institute Of Allergy & Immunology
    05/14/22
  1231. 23
    Pyridylpyridone compounds
    Sprint Bioscience
    05/14/22
  1232. 30
    Pyrrole tricyclic compounds as A2A / A2B inhibitors
    Incyte
    05/14/22
  1233. 71
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics
    05/14/22
  1234. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    Mirati Therapeutics
    05/14/22
  1235. 93
    Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
    Pfizer
    05/14/22
  1236. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    05/14/22
  1237. 4
    2,3-dihydrofuro[2,3-b]pyridine compounds
    Eli Lilly
    05/08/22
  1238. 42
    Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
    Incyte Holdings
    05/08/22
  1239. 17
    Cannabinoid receptor modulators
    Arena Pharmaceuticals
    05/08/22
  1240. 88
    Compositions for treating neurodegenerative diseases
    Cognition Therapeutics
    05/08/22
  1241. 341
    Compound, compositions, and methods
    Denali Therapeutics
    05/08/22
  1242. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics
    05/08/22
  1243. 103
    Histone demethylase inhibitors
    Celgene Quanticel Research
    05/08/22
  1244. 52
    Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
    Nanjing Huawe Medicine Technology Group
    05/08/22
  1245. 21
    Linear glycosidase inhibitors
    Asceneuron
    05/08/22
  1246. 42
    MAGL inhibitors
    H. Lundbeck
    05/08/22
  1247. 16
    Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
    Boehringer Ingelheim International
    05/08/22
  1248. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics
    05/08/22
  1249. 52
    Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
    Janssen Pharmaceutica
    05/08/22
  1250. 7
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica
    05/08/22
  1251. 32
    Compositions and methods for treating parasitic diseases
    The Regents Of The University Of California
    05/03/22
  1252. 109
    Compounds useful as inhibitors of ALCAT 1
    Perenna Pharmaceuticals
    05/03/22
  1253. 80
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences
    05/03/22
  1254. 5
    Nitrogenous tricyclic compounds and uses thereof in medicine
    Sunshine Lake Pharma
    05/03/22
  1255. 31
    Prognostic biomarkers for TTK inhibitor chemotherapy
    Netherlands Translational Research Center
    05/03/22
  1256. 20
    Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
    Sprint Bioscience
    05/03/22
  1257. 121
    Pyridone derivatives having tetrahydropyranylmethyl groups
    Daiichi Sankyo
    05/03/22
  1258. 41
    Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
    Prelude Therapeutics
    05/03/22
  1259. 53
    Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
    Bayer Pharma Aktiengesellschaft
    05/03/22
  1260. 376
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    05/03/22
  1261. 20
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte
    05/02/22
  1262. 119
    3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
    Allergan
    05/02/22
  1263. 96
    Certain chemical entities, compositions, and methods
    Neupharma
    05/02/22
  1264. 27
    HDAC6 inhibitors and imaging agents
    The General Hospital
    05/02/22
  1265. 55
    Indole derivatives and their use as protein kinase inhibitors
    Respivert
    05/02/22
  1266. 204
    Metallo-beta-lactamase inhibitors and methods of use thereof
    Merck Sharp & Dohme
    05/02/22
  1267. 117
    NLRP3 inflammasome inhibitors
    Novartis
    05/02/22
  1268. 595
    Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
    Janssen Pharmaceutica
    05/02/22
  1269. 526
    Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
    Bayer Aktiengesellschaft
    05/02/22
  1270. 1
    Sulfinylpyridines and their use in the treatment of cancer
    Oblique Therapeutics
    05/02/22
  1271. 243
    Triazolopyrimidine compounds and uses thereof
    Novartis
    05/02/22
  1272. 28
    Anti-proliferative agents for treating PAH
    Pfizer
    04/29/22
  1273. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    Novartis
    04/29/22
  1274. 247
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    04/29/22
  1275. 37
    Iridinesulfonamide compound and use method thereof
    Chia Tai Tianqing Pharmaceutical Group
    04/29/22
  1276. 281
    Kinase inhibitors and uses thereof
    Denali Therapeutics
    04/29/22
  1277. 14
    Personal care compositions comprising fatty acid amide derivatives
    Conopco
    04/29/22
  1278. 302
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences
    04/29/22
  1279. 100
    Sulfonamides as modulators of sodium channels
    Vertex Pharmaceuticals
    04/29/22
  1280. 19
    Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
    The Broad Institute
    04/29/22
  1281. 56
    Compounds targeting PRMT5
    Aligos Therapeutics
    04/25/22
  1282. 573
    Fused ring derivative having MGAT-2 inhibitory activity
    Shionogi
    04/25/22
  1283. 113
    Aminopyrimidinyl compounds
    Pfizer
    04/24/22
  1284. 16
    Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
    Glycomimetics.
    04/24/22
  1285. 115
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics
    04/24/22
  1286. 92
    N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    Kalvista Pharmaceuticals
    04/24/22
  1287. 13
    Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    Bioaxone Biosciences
    04/24/22
  1288. 30
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University-Of The Commonwealth System Of Higher Education
    04/17/22
  1289. 111
    Alkyl substituted triazole compounds as agonists of the APJ Receptor
    Amgen
    04/17/22
  1290. 377
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    04/17/22
  1291. 8
    Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
    The Johns Hopkins University
    04/17/22
  1292. 44
    Heterocyclic compounds for the inhibition of PASK
    Bioenergenix
    04/17/22
  1293. 246
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    04/17/22
  1294. 36
    N-aryl oxamic acids
    Purdue Research Foundation
    04/17/22
  1295. 6
    Pyrazoloquinazolinone antitumor agents
    The Rockefeller University
    04/17/22
  1296. 43
    Quinoline compounds as modulators of RAGE activity and uses thereof
    TBA
    04/17/22
  1297. 4
    Quinolone compounds as inhibitors of the BCL6 BTB domain protein-protein interaction and/or as BCL6 degraders
    Ontario Institute For Cancer Research (Oicr
    04/17/22
  1298. 68
    Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
    Nuvation Bio
    04/17/22
  1299. 88
    6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
    Sprint Bioscience
    04/10/22
  1300. 73
    6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative
    Ayumi Pharmaceutical
    04/10/22
  1301. 40
    Amino pyrimidine derivatives
    Novartis
    04/10/22
  1302. 46
    Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
    Ariad Pharmaceuticals
    04/10/22
  1303. 14
    Azaspiro[4.5]decane derivatives and use thereof
    Purdue Pharma
    04/10/22
  1304. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
    Jenrin Discovery
    04/10/22
  1305. 32
    Compound as ACC inhibitor and use thereof
    Nanjing Sanhome Pharmaceutical
    04/10/22
  1306. 161
    Compounds for the treatment of pain
    TBA
    04/10/22
  1307. 4
    Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor
    Incyte
    04/10/22
  1308. 95
    Cyanoindoline derivatives as NIK inhibitors
    Janssen Pharmaceutica
    04/10/22
  1309. 145
    Imidazopyrimidine derivatives
    Gilead Sciences
    04/10/22
  1310. 38
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme
    04/10/22
  1311. 59
    Pyrazole derivatives as plasma kallikrein inhibitors
    Kalvista Pharmaceuticals
    04/10/22
  1312. 130
    Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
    Aurigene Discovery Technologies
    04/10/22
  1313. 23
    Somatostatin modulators and uses thereof
    Crinetics Pharmaceuticals
    04/10/22
  1314. 562
    Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors
    Dart Neuroscience, (Cayman
    04/10/22
  1315. 183
    Substituted amino acids as integrin inhibitors
    Pliant Therapeutics
    04/10/22
  1316. 254
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    04/10/22
  1317. 6
    Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
    Shenzhen Targetrx
    04/10/22
  1318. 35
    Therapeutic heterocyclic compounds
    Gilead Sciences
    04/10/22
  1319. 212
    Vasopressin receptor antagonists and products and methods related thereto
    Blackthorn Therapeutics
    04/10/22
  1320. 13
    [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
    Eli Lilly
    04/10/22
  1321. 27
    3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
    Novartis
    04/09/22
  1322. 50
    Methods for modulating taste receptors
    Mars
    04/09/22
  1323. 64
    Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Vertex Pharmaceuticals
    04/09/22
  1324. 164
    Non-fused tricyclic compounds
    Vivace Therapeutics
    04/09/22
  1325. 45
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb
    04/09/22
  1326. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical
    04/03/22
  1327. 8
    Adrenergic receptor modulating compounds and methods of using the same
    The Board Of Trustees Of The Leland Stanford Junior University
    04/03/22
  1328. 17
    Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof
    Yangtze River Pharmaceutical Group
    04/03/22
  1329. 333
    Benzenesulfonamide compouds and their use as therapeutic agents
    Xenon Pharmaceuticals
    04/03/22
  1330. 124
    Benzimidazole compounds and derivatives as EGFR inhibitors
    Boehringer Ingelheim International
    04/03/22
  1331. 187
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    04/03/22
  1332. 59
    Compositions and methods to modulate chloride ion channel activity
    The Board Of Trustees Of The Leland Stanford Junior University
    04/03/22
  1333. 18
    Compounds, compositions and methods
    Denali Therapeutics
    04/03/22
  1334. 133
    Heterocyclic compounds as kinase inhibitors
    Nuvation Bio
    04/03/22
  1335. 29
    Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme
    04/03/22
  1336. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Biosplice Therapeutics
    04/03/22
  1337. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    04/03/22
  1338. 126
    Substituted carboxamides as inhibitors of WDR5 protein-protein binding
    Propellon Therapeutics
    04/03/22
  1339. 89
    Substituted heterocyclyl derivatives as CDK inhibitors
    Aurigene Discovery Technologies
    04/03/22
  1340. 19
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    04/03/22
  1341. 5
    Matriptase inhibitors and uses thereof
    SociÉTÉ
    03/30/22
  1342. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    03/27/22
  1343. 71
    3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
    Board Of Trustees Of The Southern Illinois University
    03/27/22
  1344. 20
    4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International
    03/27/22
  1345. 173
    ASK1 inhibiting agents
    Biogen Ma
    03/27/22
  1346. 13
    Amino-triazolopyridine compounds and their use in treating cancer
    Astrazeneca
    03/27/22
  1347. 135
    Bicyclic heteroaryl compounds and uses thereof
    Revolution Medicines
    03/27/22
  1348. 35
    CXCR2 antagonist
    Medshine Discovery
    03/27/22
  1349. 34
    Compounds and their use for reducing uric acid levels
    Acquist
    03/27/22
  1350. 67
    Dynamin-1-like protein inhibitors
    Mitobridge
    03/27/22
  1351. 10
    Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
    The Texas A&M University System
    03/27/22
  1352. 34
    Fused pyrimidine derivatives as A2A / A2B inhibitors
    Incyte
    03/27/22
  1353. 25
    Fused ring derivative used as FGFR4 inhibitor
    Jacobio Pharmaceuticals
    03/27/22
  1354. 214
    Heteroaromatic derivatives as NIK inhibitors
    Janssen Pharmaceutica
    03/27/22
  1355. 6
    Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics
    03/27/22
  1356. 8
    Indane-amines as PD-L1 antagonists
    Chemocentryx
    03/27/22
  1357. 66
    Inhibitors of Plasma Kallikrein and uses thereof
    Takeda Pharmaceutical
    03/27/22
  1358. 42
    Inhibitors of dihydroceramide desaturase for treating disease
    Centaurus Therapeutics
    03/27/22
  1359. 55
    Inhibitors of integrated stress response pathway
    Praxis Biotech
    03/27/22
  1360. 118
    JAK inhibitors
    Vimalan Biosciences
    03/27/22
  1361. 77
    Macrocycles as factor XIA inhibitors
    Bristol-Myers Squibb
    03/27/22
  1362. 42
    Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International
    03/27/22
  1363. 56
    Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
    TBA
    03/27/22
  1364. 95
    Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
    The Regents Of The University Of Michigan
    03/27/22
  1365. 7
    Pyrrolopyrimidine and pyrrolopyridine derivatives
    Galapagos
    03/27/22
  1366. 96
    Pyrrolopyrimidine derivatives as TAM inhibitors
    Incyte
    03/27/22
  1367. 239
    Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft
    03/27/22
  1368. 38
    Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
    Jiangsu Hansoh Pharmaceutical Group
    03/27/22
  1369. 115
    Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
    Array Biopharma
    03/27/22
  1370. 125
    Therapeutic compounds and uses thereof
    Genentech
    03/27/22
  1371. 135
    Thienopyridine inhibitors of RIPK2
    Celgene
    03/27/22
  1372. 22
    Thienopyrimidones
    Boehringer Ingelheim International
    03/27/22
  1373. 186
    2-quinolone derived inhibitors of BCL6
    The Institute Of Cancer Research: Royal Cancer Hospital
    03/20/22
  1374. 15
    Compounds and their use for reducing uric acid levels
    Acquist
    03/20/22
  1375. 37
    Cyclic substituted imidazo[4,5-c]quinoline derivatives
    Pfizer
    03/20/22
  1376. 113
    Fused pyrazine derivatives as A2A / A2B inhibitors
    Incyte
    03/20/22
  1377. 13
    Heterocyclic derivatives as PI3K inhibitors
    Incyte
    03/20/22
  1378. 33
    Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics
    03/20/22
  1379. 77
    Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Merck Sharp & Dohme
    03/20/22
  1380. 6
    Inhibiting the transient receptor potential al ion channel
    Eli Lilly
    03/20/22
  1381. 44
    Inhibitors of NEK7 kinase
    Halia Therapeutics
    03/20/22
  1382. 530
    Purinones as ubiquitin-specific protease 1 inhibitors
    Forma Therapeutics
    03/20/22
  1383. 48
    Pyridinone derivatives and their use as selective ALK-2 inhibitors
    Novartis
    03/20/22
  1384. 76
    Sting agonists
    Venenum Biodesign
    03/20/22
  1385. 97
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte
    03/20/22
  1386. 71
    4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof
    Shanghai Haiyan Pharmaceutical Technology
    03/13/22
  1387. 4
    Amide derivatives as Nav1.7 and Nav1.8 blockers
    Raqualia Pharma
    03/13/22
  1388. 66
    Antagonists of the muscarinic acetylcholine receptor M4
    Vanderbilt University
    03/13/22
  1389. 13
    C7 substituted oxysterols and methods of use thereof
    Sage Therapeutics
    03/13/22
  1390. 2
    Crystal form of urate transporter 1 inhibitor and preparation method and use thereof
    Tianjin Institute Of Pharmaceutical Research
    03/13/22
  1391. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    03/13/22
  1392. 30
    Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
    Topadur Pharma
    03/13/22
  1393. 35
    Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor
    Inflarx
    03/13/22
  1394. 38
    Fused triazole agonists of the APJ receptor
    Amgen
    03/13/22
  1395. 57
    Heterocycle comprising tyrosine kinase inhibitors
    Principia Biopharma
    03/13/22
  1396. 46
    MAP kinase modulators and uses thereof
    The Trustees Of Columbia University In The City Of New York
    03/13/22
  1397. 157
    Oxysterols and methods of use thereof
    Sage Therapeutics
    03/13/22
  1398. 1
    Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
    Arena Pharmaceuticals
    03/13/22
  1399. 37
    Pyrazole MAGL inhibitors
    H. Lundbeck
    03/13/22
  1400. 140
    Pyrazolopyrimidine compounds and methods of use thereof
    Genentech
    03/13/22
  1401. 17
    Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
    Dana-Farber Cancer Institute
    03/13/22
  1402. 251
    Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
    Sanofi
    03/13/22
  1403. 272
    Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
    Bayer Aktiengesellschaft
    03/13/22
  1404. 12
    Substituted nucleosides, nucleotides and analogs thereof
    Janssen Biopharma
    03/13/22
  1405. 70
    Substituted triazole derivatives and uses thereof
    Bayer Pharma Aktiengesellschaft
    03/13/22
  1406. 33
    Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
    UniversitÄT Duisburg-Essen
    03/13/22
  1407. 15
    Thrombospondin 1-binding peptide
    Daiichi Sankyo
    03/13/22
  1408. 8
    Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
    Genuv
    03/12/22
  1409. 17
    Compositions and methods for treating CNS disorders
    Sage Therapeutics
    03/12/22
  1410. 2
    Compounds as neurokinin-1 receptor antagonists and uses thereof
    Xwpharma
    03/12/22
  1411. 5
    Methods for treating GI tract disorders
    Neurogastrx
    03/12/22
  1412. 29
    Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
    Aurigene Discovery Technologies
    03/12/22
  1413. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Bayer Aktiengellschaft
    03/08/22
  1414. 715
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    Ideaya Bioscience
    03/08/22
  1415. 38
    Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Incyte
    03/08/22
  1416. 15
    Calcium channel inhibitors
    Cavion
    03/08/22
  1417. 78
    Compounds
    Mission Therapeutics
    03/08/22
  1418. 60
    Dual MAGL and FAAH inhibitors
    Abide Therapeutics
    03/08/22
  1419. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical
    03/08/22
  1420. 308
    Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein
    Prelude Therapeutics
    03/08/22
  1421. 17
    Substituted 2,3-dihydro-1H-indene analogs and methods using same
    Arbutus Biopharma
    03/08/22
  1422. 95
    Substituted benzamides as RIPK2 inhibitors
    Boehringer Ingelheim International
    03/08/22
  1423. 179
    Azalactam compounds as HPK1 inhibitors
    Pfizer
    03/04/22
  1424. 61
    Benzimidazoles and indoles as taro inhibitors
    Merck Sharp & Dohme
    03/04/22
  1425. 58
    Compositions for APP-selective BACE inhibition and uses therefor
    The Regents Of The University Of California
    03/04/22
  1426. 13
    Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
    Zhejiang Hisun Pharmaceutical
    03/04/22
  1427. 99
    Dihydropyrimidine compounds and uses thereof in medicine
    Sunshine Lake Pharma
    03/04/22
  1428. 21
    Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor
    Hangzhou Innogate Pharma
    03/04/22
  1429. 35
    Inhibitors of cyclin-dependent kinases
    Dana-Farber Cancer Institute
    03/04/22
  1430. 37
    LDHA activity inhibitors
    Arctic Pharma
    03/04/22
  1431. 3
    Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
    Poxel
    03/04/22
  1432. 99
    Oxazolidinones as taro inhibitors
    Merck Sharp & Dohme
    03/04/22
  1433. 187
    Spirocycle compounds and methods of making and using same
    H. Lundbeck
    03/04/22
  1434. 51
    Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
    Stingray Therapeutics
    03/04/22
  1435. 8
    Inhibitors of bromodomain-containing protein 4 (BRD4)
    Board Of Regents, The University Of Texas System
    03/02/22
  1436. 34
    2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
    TBA
    02/26/22
  1437. 24
    Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
    Dynavax Technologies
    02/26/22
  1438. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    02/26/22
  1439. 3
    Combination of pure 5-HT6 receptor antagonists with NMDA receptor antagonist
    Suven Life Sciences
    02/26/22
  1440. 546
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    02/26/22
  1441. 38
    Disubstituted pyrazole compounds
    Eli Lilly
    02/26/22
  1442. 33
    Heterocyclic compounds as immunomodulators
    Incyte
    02/26/22
  1443. 7
    Imidazolidine compounds
    Eli Lilly
    02/26/22
  1444. 101
    Inhibitors of glucocorticoid receptor
    Oric Pharmaceuticals
    02/26/22
  1445. 4
    Isoquinolin and naphthydrin compounds
    Eli Lilly
    02/26/22
  1446. 184
    Kappa opioid receptor antagonists and products and methods related thereto
    The Scripps Research Institute
    02/26/22
  1447. 28
    L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs
    Recurium Ip Holdings
    02/26/22
  1448. 635
    Methods and compositions of inhibiting DCN1-UBC12 interaction
    Memorial Sloan Kettering Cancer Center
    02/26/22
  1449. 62
    Neuroactive steroids, compositions, and uses thereof
    Sage Therapeutics
    02/26/22
  1450. 127
    Phenylpyrrolidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb
    02/26/22
  1451. 7
    Pyrazolo-heteroaryl derivative, preparation method and medical use thereof
    Jiangsu Hengrui Medicine
    02/26/22
  1452. 39
    Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
    TBA
    02/26/22
  1453. 22
    Selective estrogen receptor degraders
    Eli Lilly
    02/26/22
  1454. 32
    Tetrahydroisoquinolines and terahydronaphthyridines for the treatment of hepatitis B virus infection
    Hoffmann-La Roche
    02/26/22
  1455. 50
    Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
    Clavius Pharmaceuticals
    02/26/22
  1456. 117
    6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
    University Of Pittsburgh
    02/22/22
  1457. 39
    Inhibitor of apoptosis protein (IAP) antagonists
    Sanford Burnham Prebys Medical Discovery Institute
    02/22/22
  1458. 81
    Pyrazolopyrimidine compounds and uses thereof
    Incyte
    02/22/22
  1459. 12
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University Of The Holy Spirit
    02/22/22
  1460. 1227
    6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
    Shionogi
    02/21/22
  1461. 64
    Amino pyrimidine compound for inhibiting protein tyrosine kinase activity
    Shenzhen Targetrx
    02/21/22
  1462. 71
    Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb
    02/21/22
  1463. 23
    Autotaxin inhibitors
    University Of Tennessee Research Foundation
    02/21/22
  1464. 250
    Bicyclic compound and use thereof
    Sk Biopharmaceuticals
    02/21/22
  1465. 164
    Compounds, compositions, and methods
    Denali Therapeutics
    02/21/22
  1466. 53
    EPAC antagonists
    Board Of Regents, The University Of Texas System
    02/21/22
  1467. 17
    Imidazopyrazine inhibitors of Bruton's tyrosine kinase
    Acerta Pharma
    02/21/22
  1468. 62
    Methods of treating mental disorders
    The Regents Of The University Of California
    02/21/22
  1469. 43
    Pyrimidine compounds as JAK kinase inhibitors
    Theravance Biopharma R&D Ip
    02/21/22
  1470. 314
    Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
    Pfizer
    02/21/22
  1471. 27
    Sultam compound and application method thereof
    Chai Tai Tianqing Pharmaceutical Group
    02/21/22
  1472. 27
    1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors
    H. Lundbeck
    02/13/22
  1473. 47
    4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof
    TBA
    02/13/22
  1474. 843
    4-azaindole compounds
    Bristol-Myers Squibb
    02/13/22
  1475. 13
    4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament
    Boehringer Ingelheim International
    02/13/22
  1476. 262
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences
    02/13/22
  1477. 15
    Benzimidazole derivatives, preparation methods and uses thereof
    Betta Pharmaceuticals
    02/13/22
  1478. 199
    Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme
    02/13/22
  1479. 20
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche
    02/13/22
  1480. 50
    Inhibitors of hepatitis C virus replication
    Merck Sharp & Dohme
    02/13/22
  1481. 26
    JAK1 pathway inhibitors for the treatment of cytokine-related disorders
    Incyte
    02/13/22
  1482. 379
    KRAS G12C inhibitors and methods of using the same
    Amgen
    02/13/22
  1483. 223
    Macrocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    02/13/22
  1484. 21
    PTPN11 inhibitors
    Navire Pharma
    02/13/22
  1485. 188
    Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases
    Array Biopharma
    02/13/22
  1486. 14
    Pyridazines
    Boehringer Ingelheim International
    02/13/22
  1487. 138
    Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient
    Korea Research Institute Of Chemical Technology
    02/13/22
  1488. 8
    Pyrimidinones as factor XIA inhibitors
    Bristol-Myers Squibb
    02/13/22
  1489. 10
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences
    02/13/22
  1490. 2
    Salts of TAM inhibitors
    Incyte
    02/13/22
  1491. 106
    Substituted pyridines as TYK2 inhibitors
    Esker Therapeutics
    02/13/22
  1492. 233
    Substituted tricyclic compounds as FGFR inhibitors
    Incyte
    02/13/22
  1493. 96
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    02/13/22
  1494. 156
    [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
    Neurocrine Biosciences
    02/13/22
  1495. 71
    5-alkyl pyrrolidine orexin receptor agonists
    Merck Sharp & Dohme
    02/07/22
  1496. 64
    Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffmann-La Roche
    02/07/22
  1497. 149
    Bicyclic ketone compounds and methods of use thereof
    Genentech
    02/07/22
  1498. 113
    Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
    Bayer Aktiengesellschaft
    02/07/22
  1499. 116
    Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis
    02/07/22
  1500. 179
    Heteroaryl compounds as BTK inhibitors and uses thereof
    Merck Patent
    02/07/22
  1501. 103
    Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
    1St Biotherapeutics
    02/07/22
  1502. 126
    Inhibitors of RAF kinases
    Kinnate Biopharma
    02/07/22
  1503. 126
    MK2 inhibitors and uses thereof
    Celgene Car
    02/07/22
  1504. 32
    Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
    Chia Tai Tianqing Pharmaceutical Group
    02/07/22
  1505. 40
    Macrocyclic compounds as TRK kinase inhibitors and uses thereof
    Angex Pharmaceutical
    02/07/22
  1506. 26
    PRMT5 inhibitors
    Merck Sharp & Dohme
    02/07/22
  1507. 4
    Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    02/07/22
  1508. 116
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics
    02/06/22
  1509. 10
    Anti-HIV compounds
    Gilead Sciences
    02/06/22
  1510. 184
    Aryl-or heteroaryl-substituted benzene compounds
    Epizyme
    02/06/22
  1511. 21
    BRK inhibitory compound
    Ono Pharmaceutical
    02/06/22
  1512. 165
    Carbazole derivatives
    Bristol-Myers Squibb
    02/06/22
  1513. 49
    Combination therapies using immuno-dash inhibitors and PGE2 antagonists
    Trustees Of Tufts College
    02/06/22
  1514. 36
    Compounds and methods of use
    Medivation Technologies
    02/06/22
  1515. 47
    Heterocyclic compounds and uses thereof
    Celgene Car
    02/06/22
  1516. 168
    Heterocyclic compounds useful as Pim kinase inhibitors
    Incyte
    02/06/22
  1517. 18
    Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
    Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences
    02/06/22
  1518. 252
    Pharmaceutical compounds
    Almac Discovery
    02/06/22
  1519. 19
    Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
    Merck Sharp & Dohme
    02/06/22
  1520. 26
    Substituted indoline derivatives as dengue viral replication inhibitors
    Janssen Pharmaceuticals
    02/06/22
  1521. 96
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    02/02/22
  1522. 129
    CXCR7 antagonists
    Chemocentryx
    02/02/22
  1523. 25
    Compounds and compositions useful for treating disorders related to NTRK
    Blueprint Medicines
    02/02/22
  1524. 10
    Compounds that participate in cooperative binding and uses thereof
    Revolution Medicines
    02/02/22
  1525. 60
    Difluoroketamide derivatives as HtrA1 inhibitors
    Hoffmann-La Roche
    02/02/22
  1526. 376
    Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    02/02/22
  1527. 25
    MAGL inhibitors
    H. Lundbeck
    02/02/22
  1528. 24
    Macrocyclic immunomodulators
    Chemocentryx
    02/02/22
  1529. 30
    Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
    University Of South Carolina
    02/02/22
  1530. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica
    02/02/22
  1531. 30
    Substituted purines as TLR7 agonists
    Primmune Therapeutics
    02/02/22
  1532. 56
    Triazolopyridine inhibitors of myeloperoxidase
    Bristol-Myers Squibb
    02/02/22
  1533. 78
    1-cyano-pyrrolidine derivatives as inhibitors of USP30
    Mission Therapeutics
    01/30/22
  1534. 4
    Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
    Ucb Biopharma
    01/30/22
  1535. 6
    Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
    AchÉ
    01/30/22
  1536. 7
    Hydantoins that modulate BACE-mediated app processing
    Buck Institute For Research On Aging
    01/30/22
  1537. 40
    Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor
    Shengke Pharmaceuticals (Jiangsu
    01/30/22
  1538. 200
    Isoxazolyl ether derivatives as GABAA α5 PAM
    Hoffmann-La Roche
    01/30/22
  1539. 63
    Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
    Ardelyx
    01/30/22
  1540. 113
    PI-kinase inhibitors with anti-infective activity
    The Regents Of The University Of California
    01/30/22
  1541. 46
    Protein kinase inhibitors, preparation method and medical use thereof
    Gan & Lee Pharmaceuticals
    01/30/22
  1542. 70
    SHMT inhibitors and uses thereof
    Raze Therapeutics
    01/30/22
  1543. 218
    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
    Mirati Therapeutics
    01/30/22
  1544. 270
    Tricyclic heterocycles as BET protein inhibitors
    Incyte
    01/30/22
  1545. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics
    01/24/22
  1546. 27
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    Mission Therapeutics
    01/24/22
  1547. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
    Kalvista Pharmaceuticals
    01/24/22
  1548. 107
    Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
    Jiangsu Hengrui Medicine
    01/24/22
  1549. 51
    Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
    Korea Research Institute Of Chemical Technology
    01/24/22
  1550. 26
    Salts and processes of preparing a PI3K inhibitor
    Incyte
    01/24/22
  1551. 51
    Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors
    Daewoong Pharmaceutical
    01/24/22
  1552. 713
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    Ideaya Biosciences
    01/23/22
  1553. 565
    Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    01/23/22
  1554. 33
    Benzofuran derivative, preparation method thereof and use thereof in medicine
    Jiangsu Hengrui Medicine
    01/23/22
  1555. 6
    Ethynyl derivatives
    Hoffmann-La Roche
    01/23/22
  1556. 70
    Heterocyclic compounds useful as dual ATX/CA inhibitors
    Hoffmann-La Roche
    01/23/22
  1557. 28
    Imidazolyl tricyclic enones as antioxidant inflammation modulators
    Reata Pharmaceuticals
    01/23/22
  1558. 122
    Imidazopiperazine inhibitors of transcription activating proteins
    Board Of Regents, The University Of Texas System
    01/23/22
  1559. 9
    Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
    Regents Of The University Of Colorado, A Body Corporate
    01/23/22
  1560. 118
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    01/23/22
  1561. 21
    Isoquinoline-steroid conjugates and uses thereof
    Aerie Pharmaceuticals
    01/23/22
  1562. 84
    Methods to induce targeted protein degradation through bifunctional molecules
    Dana-Farber Cancer Institute
    01/23/22
  1563. 31
    Oxime ether compounds
    Bristol-Myers Squibb
    01/23/22
  1564. 21
    Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
    Pharmakea
    01/23/22
  1565. 7
    ROR-gamma modulators and uses thereof
    Piramal Enterprises
    01/23/22
  1566. 12
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    01/23/22
  1567. 7
    Substituted cyanopyrrolidines with activity as DUB inhibitors
    Mission Therapeutics
    01/23/22
  1568. 158
    5-membered and bicyclic heterocyclic amides as inhibitors of rock
    Bristol-Myers Squibb
    01/16/22
  1569. 17
    6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
    Sprint Bioscience
    01/16/22
  1570. 14
    Amino-fluoropiperidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical
    01/16/22
  1571. 69
    Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
    TBA
    01/16/22
  1572. 39
    Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    01/16/22
  1573. 201
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences
    01/16/22
  1574. 32
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingelheim International
    01/16/22
  1575. 13
    Heteroaryl amides as inhibitors of protein aggregation
    Ucb Biophama
    01/16/22
  1576. 51
    Heterocyclic derivatives as PI3K inhibitors
    Incyte
    01/16/22
  1577. 17
    Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same
    Duquesne University Of The Holy Spirit
    01/16/22
  1578. 155
    Quinolone derivatives as fibroblast growth factor receptor inhibitors
    Principia Biopharma
    01/16/22
  1579. 155
    ROR γ modulators
    Bristol-Myers Squibb
    01/16/22
  1580. 3
    Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Yeda Research And Development
    01/16/22
  1581. 42
    Selective inhibitors of protein arginine methlytransferase 5 (PRMT5)
    Prelude Therapeutics
    01/16/22
  1582. 819
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn
    01/16/22
  1583. 354
    Tetrahydroquinoline derivatives as P2X7 receptor antagonists
    Raqualia Pharma
    01/16/22
  1584. 60
    Triazolopyrazine
    TBA
    01/16/22
  1585. 2
    Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
    Bayer Animal Health
    01/16/22
  1586. 229
    COMPOUNDS
    Enterprise Therapeutics
    01/13/22
  1587. 179
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences
    01/13/22
  1588. 115
    Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    Pharmakea
    01/09/22
  1589. 29
    1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
    Addex Pharmaceuticals
    01/07/22
  1590. 21
    Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
    Bayer Pharma Aktiengesellschaft
    01/07/22
  1591. 101
    Bicyclic amide compounds and methods of use thereof
    Genentech
    01/07/22
  1592. 223
    Bicyclic sulfones and sulfoxides and methods of use thereof
    Genentech
    01/07/22
  1593. 215
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    Galapagos
    01/07/22
  1594. 41
    Inhibitors of RIP1 kinase and methods of use thereof
    Genentech
    01/07/22
  1595. 13
    Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
    Celon Pharma
    01/07/22
  1596. 31
    Small molecule inhibitors of Galectin-3
    Bristol-Myers Squibb
    01/07/22
  1597. 201
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences
    01/07/22
  1598. 275
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    01/07/22
  1599. 146
    2,2-difluorodioxolo A2A receptor antagonists
    Merck Sharp & Dohme
    12/28/21
  1600. 19
    Androgen receptor modulating compounds
    Orion
    12/28/21
  1601. 26
    Galactoside inhibitor of galectins
    Galecto Biotech
    12/28/21
  1602. 175
    Glycosidase inhibitors
    Asceneuron
    12/28/21
  1603. 198
    Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
    Sk Biopharmaceuticals
    12/28/21
  1604. 48
    Sulfonamide compounds
    Daiichi Sankyo
    12/28/21
  1605. 45
    2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
    DompÉ
    12/27/21
  1606. 729
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    Ideaya Biosciences
    12/27/21
  1607. 5
    Alkylphenyl compounds
    Bristol-Myers Squibb
    12/27/21
  1608. 127
    Aminopyrazine derivatives as PI3K-γ inhibitors
    Incyte
    12/27/21
  1609. 26
    Azetidine derivative, preparation method therefor, and use thereof
    Sichuan Kelun-Biotech Biopharmaceutical
    12/27/21
  1610. 148
    Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
    Board Of Regents, The University Of Texas System
    12/27/21
  1611. 12
    Dihydropyrimidinyl benzazepine carboxamide compounds
    Hoffmann-La Roche
    12/27/21
  1612. 39
    Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech
    12/27/21
  1613. 198
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    12/27/21
  1614. 436
    Heteroaryl-substituted triazoles as APJ receptor agonists
    Amgen
    12/27/21
  1615. 36
    Hydroxamic acids comprising pyrazole moiety and uses thereof
    Hawaii Biotech
    12/27/21
  1616. 70
    Indolinones compounds and their use in the treatment of fibrotic diseases
    Respivert
    12/27/21
  1617. 202
    Inhibitor compounds
    Cancer Research Technology
    12/27/21
  1618. 35
    Piperazine substituted azapine derivatives and uses thereof
    Alairion
    12/27/21
  1619. 27
    Piperazinyl norbenzomorphan compounds and methods for using the same
    Board Of Regents, The University Of Texas System
    12/27/21
  1620. 41
    Piperidines as covalent menin inhibitors
    The Regents Of The University Of Michigan
    12/27/21
  1621. 208
    Piperidinyl-3-(aryloxy)propanamides and propanoates
    Takeda Pharmaceutical
    12/27/21
  1622. 159
    Selective estrogen receptor down-regulators
    Astrazeneca
    12/27/21
  1623. 8
    Substituted isoquionline derivatives as immunomudulators
    Bristol-Myers Squibb
    12/27/21
  1624. 33
    Substituted piperidines for the treatment of cancer
    Les Laboratoires Servier
    12/27/21
  1625. 1145
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    12/27/21
  1626. 30
    Thiadiazole IRAK4 compounds
    Gilead Sciences
    12/27/21
  1627. 271
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics
    12/23/21
  1628. 964
    Cot modulators and methods of use thereof
    Gilead Sciences
    12/23/21
  1629. 57
    Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
    Guangzhou Maxinovel Pharmaceuticals
    12/20/21
  1630. 211
    Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
    Shionogi
    12/20/21
  1631. 6
    Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
    Incyte
    12/20/21
  1632. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica
    12/20/21
  1633. 478
    3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
    Merck Sharp & Dohme
    12/19/21
  1634. 329
    Arylquinazolines
    Merck Patent
    12/19/21
  1635. 55
    Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
    Arvinas Operations
    12/19/21
  1636. 26
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer
    12/19/21
  1637. 102
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    12/19/21
  1638. 13
    Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
    Dana-Farber Cancer Institute
    12/19/21
  1639. 14
    Benzimidazole-proline derivatives
    Idorsia Pharmaceuticals
    12/14/21
  1640. 135
    Metalloenzyme inhibitor compounds
    Phasebio Pharmaceuticals
    12/14/21
  1641. 10
    Methods of identifying SENP1 inhibitors
    City Of Hope
    12/14/21
  1642. 17
    Pyridine derivative as ASK1 inhibitor and preparation method and use thereof
    TBA
    12/14/21
  1643. 11
    Quinazoline compound for EGFR inhibition
    Medshine Discovery
    12/14/21
  1644. 32
    Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
    Principia Biopharma
    12/14/21
  1645. 4
    Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
    Blueprint Medicines
    12/14/21
  1646. 11
    TYK2 inhibitors, uses, and methods for production thereof
    Nimbus Lakshmi
    12/14/21
  1647. 42
    VMAT2 inhibitor compounds and compositions thereof
    Neurocrine Biosciences
    12/14/21
  1648. 146
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences
    12/06/21
  1649. 11
    Farnesoid X receptor modulators
    Intercept Pharmaceuticals
    12/06/21
  1650. 5
    Methods to determine KDM1A target engagement and chemoprobes useful therefor
    Oryzon Genomics
    12/06/21
  1651. 99
    Apoptosis signal-regulating kinase inhibitors and uses thereof
    Sichuan Haisco Pharmaceutical
    12/05/21
  1652. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent
    12/05/21
  1653. 551
    Compounds of formulas (VII), (VIII), (IX), (XI), (XII), (XIII), and (XIV) as muscarinic receptor 4(M4) antagonists for treating neurological diseases
    Neurocrine Biosciences
    12/05/21
  1654. 16
    Diacylglycerol acyl transferase 2 inhibitors
    Pfizer
    12/05/21
  1655. 17
    Ethynyl derivatives
    Hoffmann-La Roche
    12/05/21
  1656. 52
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Nikang Therapeutics
    12/05/21
  1657. 390
    Naphthyridines as inhibitors of HPK1
    Genentech
    12/05/21
  1658. 53
    Poly-ADP ribose polymerase (PARP) inhibitors
    Mitobridge
    12/05/21
  1659. 94
    Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech
    12/05/21
  1660. 65
    Pyridinyl pyrazoles as modulators of RORγT
    Janssen Pharmaceutica
    12/05/21
  1661. 366
    Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders
    The Scripps Research Institute
    12/05/21
  1662. 67
    Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
    Merck Sharp & Dohme
    12/05/21
  1663. 825
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn
    12/05/21
  1664. 35
    1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
    Merck Patent
    11/29/21
  1665. 166
    1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
    Amgen
    11/29/21
  1666. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck
    11/29/21
  1667. 3
    3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
    Ctxt
    11/29/21
  1668. 205
    4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
    Array Biopharma
    11/29/21
  1669. 35
    Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
    Bristol-Myers Squibb
    11/29/21
  1670. 6
    Cyclic dinucleotides as sting agonists
    Janssen Biotech
    11/29/21
  1671. 145
    Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
    Board Of Regents, The University Of Texas System
    11/29/21
  1672. 134
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics
    11/29/21
  1673. 7
    Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics
    11/29/21
  1674. 12
    Heterocyclic compounds as adenosine antagonists
    Nuvation Bio
    11/29/21
  1675. 23
    Indolizine derivatives and their application in medicine
    Kind Pharmaceutical
    11/29/21
  1676. 97
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    11/29/21
  1677. 131
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    11/29/21
  1678. 34
    Piperidinyl-propanone derivatives
    Merck Patent
    11/29/21
  1679. 18
    Second generation GRP94-selective inhibitors
    University Of Kansas
    11/29/21
  1680. 36
    Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
    Merck Sharp & Dohme
    11/29/21
  1681. 812
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn
    11/29/21
  1682. 823
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists
    Nimbus Saturn
    11/29/21
  1683. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme
    11/29/21
  1684. 36
    Substituted pyrimidines as LRKK2 inhibitors
    Denali Therapeutics
    11/29/21
  1685. 7
    Tetrahydroquinoline-based bromodomain inhibitors
    St. Jude Children's Research Hospital
    11/29/21
  1686. 90
    Therapeutic compounds and methods of use thereof
    Genentech
    11/29/21
  1687. 145
    Therapeutic inhibitory compounds
    Attune Pharmaceuticals
    11/29/21
  1688. 207
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals
    11/29/21
  1689. 76
    Tricyclic heterocyclic derivatives and uses thereof
    Auckland Uniservices
    11/29/21
  1690. 42
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    Max-DelbrÜCk-Centrum FÜR Molekulare Medizin
    11/29/21
  1691. 491
    [1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient
    Dong Wha Pharm.
    11/29/21
  1692. 299
    Amino-pyrrolopyrimidinone compounds and methods of use thereof
    Arqule
    11/28/21
  1693. 169
    Biaryloxy derivatives as TTX-S blockers
    Raqualia Pharma
    11/28/21
  1694. 150
    Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
    Wigen Biomedicine Technology (Shanghai)
    11/28/21
  1695. 44
    Compounds and their use for reducing uric acid levels
    Acquist
    11/28/21
  1696. 115
    Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
    Amgen
    11/28/21
  1697. 396
    Therapeutic compounds
    Celgene Quanticel Research
    11/28/21
  1698. 27
    Type of aryl benzofuran amidated derivative and medical use thereof
    China Pharmaceutical University
    11/28/21
  1699. 36
    2,6-disubstituted pyridine derivative
    Sumitomo Dainippon Pharma
    11/22/21
  1700. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    11/22/21
  1701. 569
    CDK2 inhibitors
    Pfizer
    11/22/21
  1702. 68
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    Mission Therapeutics
    11/22/21
  1703. 35
    Factor XIIa inhibitors
    Merck Sharp & Dohme
    11/22/21
  1704. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    11/22/21
  1705. 72
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    11/22/21
  1706. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals
    11/22/21
  1707. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte
    11/22/21
  1708. 800
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics
    11/22/21
  1709. 30
    Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit MNK1 and MNK2
    Effector Therapeutics
    11/22/21
  1710. 79
    Triazolopyrimidine, triazolopyridine compounds, and the composition thereof for treating PRC2-mediated diseases
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    11/22/21
  1711. 202
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche
    11/22/21
  1712. 25
    C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    11/15/21
  1713. 155
    Compounds and methods for modulating interleukin-2-inducible t-cell kinase
    Corvus Pharmaceuticals
    11/15/21
  1714. 8
    Compounds useful for inhibiting RORγt
    Eli Lilly
    11/15/21
  1715. 8
    Cycloalkyl-diamines for the treatment of pain
    Medisynergics
    11/14/21
  1716. 21
    Piperidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb
    11/14/21
  1717. 359
    Pyridazine derivatives as RORc modulators
    Genentech
    11/14/21
  1718. 420
    Quinazolinones as PARP14 inhibitors
    Ribon Therapeutics
    11/14/21
  1719. 85
    Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    11/14/21
  1720. 15
    1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
    Astrazeneca
    11/08/21
  1721. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly
    11/08/21
  1722. 88
    Alkyl pyrrolopyrimidine analogs and methods of making and using same
    The University Of North Carolina At Chapel Hill
    11/08/21
  1723. 6
    Aminopyrimidinecarboxamides as CXCR2 modulators
    Syntrix Biosystems
    11/08/21
  1724. 899
    Benzolactam compounds as protein kinase inhibitors
    Otsuka Pharmaceutical
    11/08/21
  1725. 11
    Compound useful for the treatment of degenerative and inflammatory diseases
    Galapagos
    11/08/21
  1726. 59
    Compounds and their uses as ACC inhibitors
    Nanjing Ruijie Pharmatech
    11/08/21
  1727. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics
    11/08/21
  1728. 22
    Difluoroketamide derivatives as HTRA1 inhibitors
    Hoffman-La Roche
    11/08/21
  1729. 16
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    11/08/21
  1730. 13
    Disubstituted compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    11/08/21
  1731. 44
    Histone demethylase inhibitors
    Celgene Quanticel Research
    11/08/21
  1732. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    Kalvista Pharmaceuticals
    11/08/21
  1733. 13
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University Of The Holy Spirit
    11/08/21
  1734. 10
    Pyrimidine derivative, method for preparing same and use thereof in medicine
    TBA
    11/08/21
  1735. 136
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent
    11/08/21
  1736. 81
    SSAO inhibitor
    TBA
    11/08/21
  1737. 15
    Acetyl-CoA carboxylase modulators
    Monsanto Technology
    11/04/21
  1738. 108
    EGFR proteolysis targeting chimeric molecules and associated methods of use
    Arvinas Operations
    11/04/21
  1739. 57
    Inhibitors of protease-activated receptor-2
    Heptares Therapeutics
    11/04/21
  1740. 162
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    The Institute Of Cancer Research: Royal Cancer Hospital
    11/04/21
  1741. 218
    PARG inhibitory compounds
    Cancer Research Technology
    11/04/21
  1742. 116
    Pyrrolidine derivative
    Kissei Pharmaceutical
    11/04/21
  1743. 19
    Substituted dihydrobenzofuran glycosidase inhibitors
    Asceneuron
    11/04/21
  1744. 92
    Zaindole derivatives and their use as ERK kinase inhibitors
    Agv Discovery
    11/04/21
  1745. 53
    1,2,4-triazine-4-amine derivatives
    Heptares Therapeutics
    11/01/21
  1746. 32
    Alpha-D-galactoside inhibitors of galectins
    Galecto Biotech
    11/01/21
  1747. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    11/01/21
  1748. 77
    Bicyclic lactams and methods of use thereof
    Genentech
    11/01/21
  1749. 136
    Compounds
    Astrazeneca
    11/01/21
  1750. 99
    IRAK4 inhibitor and use thereof
    Beijing Hanmi Pharmaceutical
    11/01/21
  1751. 2
    Immunomodulators
    Bristol-Myers Squibb
    11/01/21
  1752. 23
    Inhibitors of influenza virus replication and uses thereof
    Sunshine Lake Pharma
    11/01/21
  1753. 440
    MCL-1 inhibitors
    Gilead Sciences
    11/01/21
  1754. 20
    Potent and selective mu opioid receptor modulators
    Virginia Commonwealth University
    11/01/21
  1755. 37
    Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
    Japan Tobacco
    11/01/21
  1756. 532
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech
    11/01/21
  1757. 55
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer
    11/01/21
  1758. 204
    Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme
    11/01/21
  1759. 140
    Substituted pyrimidines as cyclin-dependent kinase inhibitors
    Shanghai Pharmaceuticals Holding
    11/01/21
  1760. 229
    Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
    Daewoong Pharmaceutical
    10/27/21
  1761. 25
    Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
    Dart Neuroscience
    10/27/21
  1762. 1
    Substituted thiohydantoin derivatives as androgen receptor antagonists
    Janssen Pharmaceutica
    10/27/21
  1763. 11
    Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Companay
    10/27/21
  1764. 61
    1,3,4-thiadiazole compounds and their use in treating cancer
    Cancer Research Technology
    10/26/21
  1765. 18
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    10/26/21
  1766. 113
    Aminopyrimidinyl compounds
    Pfizer
    10/26/21
  1767. 25
    Benzothiophene estrogen receptor modulators
    G1 Therapeutics
    10/26/21
  1768. 236
    Biaryl kinase inhibitors
    Bristol-Myers Squibb
    10/26/21
  1769. 19
    Compound for inhibiting IDO, a manufacturing method and a use thereof
    Shanghai Joyu Pharmatech
    10/26/21
  1770. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences
    10/26/21
  1771. 49
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    10/26/21
  1772. 210
    Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
    Janssen Pharmaceutica
    10/26/21
  1773. 22
    Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase
    Board Of Regents, The University Of Texas System
    10/26/21
  1774. 5
    Inhibitors of soluble adenylyl cyclase
    Cornell University
    10/26/21
  1775. 85
    Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
    Astex Therapeutics
    10/26/21
  1776. 329
    PRMT5 inhibitors and uses thereof
    Epizyme
    10/26/21
  1777. 51
    Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
    Aclaris Therapeutics
    10/26/21
  1778. 30
    Therapeutic inhibitory compounds
    Attune Pharmaceuticals
    10/26/21
  1779. 164
    Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
    Bristol-Myers Squibb
    10/26/21
  1780. 95
    Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
    Beijing Scitech-Mq Pharmaceuticals
    10/26/21
  1781. 135
    4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
    TBA
    10/20/21
  1782. 92
    6-aminopyridin-3-yl pyrazoles as modulators of RORgT
    Janssen Pharmaceutica
    10/20/21
  1783. 440
    6-aminopyridin-3-yl thiazoles as modulators of RORγT
    Janssen Pharmaceutica
    10/20/21
  1784. 25
    Bis-heteroaryl derivatives as modulators of protein aggregation
    Ucb Biopharma
    10/20/21
  1785. 71
    Compounds and compositions for inhibiting the activity of SHP2
    Novartis
    10/20/21
  1786. 28
    Grp94 selective inhibitors and uses thereof
    University Of Kansas
    10/20/21
  1787. 134
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent
    10/20/21
  1788. 4
    Imidazolyl kinase inhibitors and uses thereof
    Dana-Farber Cancer Institute
    10/20/21
  1789. 185
    KDM5 inhibitors
    Merck Sharp & Dohme
    10/20/21
  1790. 22
    Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute Of Materia Medica, Chinese Academy Of Medical Sciences
    10/20/21
  1791. 146
    Pharmaceutical compounds
    Sentinel Oncology
    10/20/21
  1792. 225
    Phenyl substituted pyrazoles as modulators of RORγt
    Janssen Pharmaceutica
    10/20/21
  1793. 150
    Pyridine derivative
    Astellas Pharma
    10/20/21
  1794. 27
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    10/20/21
  1795. 16
    Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
    Glaxosmithkline Intellectual Property Development
    10/20/21
  1796. 644
    Substituted pyridines as inhibitors of DNMT1
    Glaxosmithkline Intellectual Property Development
    10/20/21
  1797. 297
    4,5-annulated 1,2,4-triazolones
    Bayer Aktiengesellschaft
    10/09/21
  1798. 34
    Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
    The Research Foundation For The State University Of New York
    10/09/21
  1799. 114
    Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    1St Biotherapeutics
    10/09/21
  1800. 35
    Biaryltriazole inhibitors of macrophage migration inhibitory factor
    Yale University
    10/09/21
  1801. 29
    Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    10/09/21
  1802. 35
    Cyclopentane-based modulators of STING (stimulator of interferon genes)
    Pfizer
    10/09/21
  1803. 107
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    10/09/21
  1804. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    Proximagen
    10/09/21
  1805. 45
    Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    10/09/21
  1806. 13
    Macrocyclic compounds as ROS1 kinase inhibitors
    Array Biopharma
    10/09/21
  1807. 189
    Pyrido five-element aromatic ring compound, preparation method therefor and use thereof
    Shanghai Haihe Pharmaceutical
    10/09/21
  1808. 273
    Pyrrolo[2,3-d]pyrimidine derivatives
    Pfizer
    10/09/21
  1809. 13
    Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
    Incyte
    10/09/21
  1810. 22
    Synergistic combination of immunologic inhibitors for the treatment of cancer
    The University Of Chicago
    10/09/21
  1811. 91
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    10/09/21
  1812. 23
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals
    10/09/21
  1813. 90
    USP30 inhibitors
    Mitobridge
    10/09/21
  1814. 63
    (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor
    Astrazeneca
    10/04/21
  1815. 66
    Chemical compounds
    Astrazeneca
    10/04/21
  1816. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    Legochem Biosciences
    10/04/21
  1817. 66
    Farnesoid X receptor agonists and uses thereof
    Metacrine
    10/04/21
  1818. 145
    Inhibiting agents for Bruton's tyrosine kinase
    Biogen Ma
    10/04/21
  1819. 66
    JAK1 selective inhibitors
    Astrazeneca
    10/04/21
  1820. 21
    Modulators of the sigma-2 receptor and their method of use
    Temple University-Of The Commonwealth System Of Higher Education
    10/04/21
  1821. 45
    Oxazole derivatives for use in the treatment of cancer
    Lifearc
    10/04/21
  1822. 3
    PRMT5 inhibitors
    Ctxt
    10/04/21
  1823. 180
    Pyrazolopyrimidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical
    10/04/21
  1824. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals
    10/04/21
  1825. 512
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    10/04/21
  1826. 568
    Substituted pyrazines as ATR kinase inhibitors
    Vertex Pharmaceuticals
    10/04/21
  1827. 119
    Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
    Celgene Quanticel Research
    10/04/21
  1828. 145
    1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
    The Trustees Of The University Of Pennsylvania
    09/28/21
  1829. 75
    1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
    Shijiazhuang Sagacity New Drug Development
    09/28/21
  1830. 27
    Azaindoles as inhibitors of HPK1
    Genentech
    09/28/21
  1831. 90
    BMP-signal-inhibiting compound
    Riken
    09/28/21
  1832. 11
    Compounds and uses thereof
    Kala Pharmaceuticals
    09/28/21
  1833. 60
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme
    09/28/21
  1834. 108
    Heterocyclic compounds as ret kinase inhibitors
    Cancer Research Technology
    09/28/21
  1835. 239
    Heterocyclic compounds for the inhibition of pask
    Bioenergenix
    09/28/21
  1836. 19
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D Ip
    09/28/21
  1837. 261
    Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D Ip
    09/28/21
  1838. 97
    Methods of treating intraocular pressure with activators of Tie-2
    Aerpio Pharmaceuticals
    09/28/21
  1839. 444
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica
    09/28/21
  1840. 15
    Selective NR2B antagonists
    Bristol-Myers Squibb
    09/28/21
  1841. 43
    Sigma receptor binders
    Board Of Regents, The University Of Texas System
    09/28/21
  1842. 22
    Substituted heterocyclic inhibitors of PTPN11
    Navire Pharma
    09/28/21
  1843. 134
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    09/28/21
  1844. 556
    Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    09/28/21
  1845. 88
    1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
    St. Jude Children''S Rsearch Hospital
    09/26/21
  1846. 87
    Aminopyridine derivatives and their use as selective ALK-2 inhibitors
    Novartis
    09/26/21
  1847. 4
    Beta adrenergic agonist and methods of using the same
    Curasen Therapeutics
    09/26/21
  1848. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte
    09/26/21
  1849. 23
    Bicyclic pyridone lactams and methods of use thereof
    Genentech
    09/26/21
  1850. 3
    Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body
    Pfizer
    09/26/21
  1851. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    09/26/21
  1852. 79
    Heteroaryl SYK inhibitors
    Boehringer Ingelheim International
    09/26/21
  1853. 449
    Heteroaryl compounds and their use as therapeutic drugs
    Dong-A Socio Holdings
    09/26/21
  1854. 72
    Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme
    09/26/21
  1855. 135
    Inhibitors of Hepatitis C virus polymerase
    Cocrystal Pharma
    09/26/21
  1856. 547
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica
    09/26/21
  1857. 33
    Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease
    TBA
    09/26/21
  1858. 12
    PRMT5 inhibitors
    Merck Sharp & Dohme
    09/26/21
  1859. 26
    Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
    Seoul National University Hospital
    09/26/21
  1860. 18
    Substituted oxazines as beta-secretase inhibitors
    Amgen
    09/26/21
  1861. 11
    Tank-binding kinase-1 PROTACs and associated methods of use
    Arvinas Operations
    09/26/21
  1862. 38
    Therapeutic compounds and methods of use thereof
    Genentech
    09/26/21
  1863. 391
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals
    09/26/21
  1864. 6
    Treatment and diagnosis of melanoma
    The Rockefeller University
    09/26/21
  1865. 1
    [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
    Janssen Pharmaceutica
    09/26/21
  1866. 26
    Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute Of Materia Medica, Chinese Academy Of Medical Sciences
    09/20/21
  1867. 499
    Bromodomain inhibitors
    Celgene Quanticel Research
    09/20/21
  1868. 29
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda
    09/20/21
  1869. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics
    09/20/21
  1870. 8
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    09/20/21
  1871. 3
    Kinase inhibitors
    Oxular Acquisitions
    09/20/21
  1872. 31
    Methods for inhibiting fascin
    Novita Pharmaceuticals
    09/20/21
  1873. 88
    Quinoline and isoquinoline derivatives for treating pain and pain related conditions
    Esteve Pharmaceuticals
    09/20/21
  1874. 131
    4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
    Merck Sharp & Dohme
    09/12/21
  1875. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Samumed
    09/12/21
  1876. 28
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    Daegu-Gyeongbuk Medical Innovation Foundation
    09/12/21
  1877. 214
    Bruton's tyrosine kinase inhibitors
    Suzhou Baijibugong Pharmaceutical Technology
    09/12/21
  1878. 61
    Compounds and compositions for inhibiting the activity of SHP2
    Novartis
    09/12/21
  1879. 472
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica
    09/12/21
  1880. 236
    Pyrazolopyridine compounds and uses thereof
    Incyte
    09/12/21
  1881. 32
    SHMT inhibitors
    The Trustees Of Princeton University
    09/12/21
  1882. 288
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics
    09/12/21
  1883. 87
    Spirocyclic compounds
    Recurium Ip Holdings
    09/12/21
  1884. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme
    09/12/21
  1885. 44
    Benzothiazole derivatives as DYRK1 inhibitors
    Pharmasum Therapeutics
    09/06/21
  1886. 45
    CDK inhibitors
    Gi Therapeutics
    09/06/21
  1887. 31
    Cyano-subtituted heterocycles with activity as inhibitors of USP30
    Mission Therapeutics
    09/06/21
  1888. 48
    HSP90B N-terminal isoform-selective inhibitors
    University Of Kansas
    09/06/21
  1889. 62
    Inhibitors of RAF kinases
    Kinnate Biopharma
    09/06/21
  1890. 69
    Intermediate compound of novel tetrahydronaphthyl urea derivative
    Mochida Pharmaceutical
    09/06/21
  1891. 35
    Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
    Arena Pharmaceuticals
    09/06/21
  1892. 112
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Esteve Pharmaceuticals.
    09/06/21
  1893. 248
    Pyrazole MAGL inhibitors
    Lundbeck La Jolla Research Center
    09/06/21
  1894. 48
    Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme
    09/06/21
  1895. 7
    Treatment of conditions associated with hyperinsulinaemia
    Tensha Therapeutics
    09/06/21
  1896. 26
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The Usa, As Represented By The Secretary, Department Of Health And Human Services
    09/06/21
  1897. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals
    09/02/21
  1898. 18
    Azetidine derivatives
    Vernalis (R&D
    09/02/21
  1899. 56
    Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    09/02/21
  1900. 9
    Cannabidiol derivatives as inhibitors of the HIF prolyl hydroxylases activity
    Emerald Health Pharmaceuticals
    09/02/21
  1901. 463
    Compounds and uses thereof
    Yumanity Therapeutics
    09/02/21
  1902. 18
    Cyclohexene compounds and use thereof
    Guangzhou Henovcom Bioscience
    09/02/21
  1903. 6
    Fused imidazoles as mIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    09/02/21
  1904. 23
    Hetero-halo inhibitors of histone deacetylase
    Alkermes
    09/02/21
  1905. 3
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    09/02/21
  1906. 5
    Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
    Incyte Holdings
    09/02/21
  1907. 12
    Imidazopyrazine compounds, preparation methods and uses thereof
    Dongguan Zhenxing-Beite Medicine Technology
    09/02/21
  1908. 407
    Immunomodulator compounds
    Chemocentryx
    09/02/21
  1909. 68
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences
    09/02/21
  1910. 1
    Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    Galapagos
    09/02/21
  1911. 56
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
    Boehringer Ingelheim International
    09/02/21
  1912. 51
    Substituted tricyclic heterocyclic compounds and use thereof
    Lifearc
    09/02/21
  1913. 49
    Thiazole derivative and applications
    East China University Of Science And Technology
    09/02/21
  1914. 70
    Thioacetate compounds, compositions and methods of use
    Ardea Biosciences
    09/02/21
  1915. 37
    Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb
    09/02/21
  1916. 80
    Tricyclic ASK1 inhibitors
    Terns
    09/02/21
  1917. 99
    Benzene disulfonamide for the treatment of cancer
    Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften
    08/30/21
  1918. 14
    Bis-heteroaryl derivatives as modulators of protein aggregation
    Ucb Biopharma
    08/30/21
  1919. 107
    Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
    H. Lundbeck
    08/30/21
  1920. 16
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    08/30/21
  1921. 20
    LRRK2 inhibitors and methods of making and using the same
    Dana-Farber Cancer Institute
    08/30/21
  1922. 47
    Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
    Hoffmann-La Roche
    08/30/21
  1923. 110
    Oxadiazolones as transient receptor potential channel inhibitors
    Genentech
    08/30/21
  1924. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    08/30/21
  1925. 67
    Pyrimidine FGFR4 inhibitors
    Eisai R&D Management
    08/30/21
  1926. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees Of Columbia University In The City Of New York
    08/30/21
  1927. 50
    Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    08/30/21
  1928. 219
    Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
    Valo Early Discovery
    08/30/21
  1929. 111
    Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
    H. Lundbeck
    08/22/21
  1930. 42
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics
    08/22/21
  1931. 14
    Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
    Centre National De La Recherche Scientifique
    08/22/21
  1932. 52
    Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
    Jiangsu Hengrui Medicine
    08/22/21
  1933. 65
    Heterocyclic compounds as immunomodulators
    Incyte
    08/22/21
  1934. 7
    Kinase inhibitors for the treatment of disease
    Dana Farber Cancer Institute
    08/22/21
  1935. 198
    Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
    Pfizer
    08/22/21
  1936. 20
    Substituted piperazines as ROR-gamma modulators
    Escalier Biosciences
    08/22/21
  1937. 370
    Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
    Leo Pharma
    08/22/21
  1938. 103
    Triazole phenyl compounds as agonists of the APJ receptor
    Amgen
    08/22/21
  1939. 34
    IRAK4 modulators
    Genentech
    08/16/21
  1940. 71
    IRAK4 modulators
    Genentech
    08/16/21
  1941. 4
    3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
    Jiangsu Hengrui Medicine
    08/15/21
  1942. 32
    Benzothiazole compounds and uses thereof
    Incyte
    08/15/21
  1943. 33
    Imidazo isoindole derivative, preparation method therefor and medical use thereof
    Jiangsu Hengrui Medicine
    08/15/21
  1944. 124
    Imidazopiperazinone inhibitors of transcription activating proteins
    Board Of Regents, The University Of Texas System
    08/15/21
  1945. 110
    Inhibiting agents for Bruton's tyrosine kinase
    Biogen Ma
    08/15/21
  1946. 427
    PD-1/PD-L1 inhibitors
    Gilead Sciences
    08/15/21
  1947. 23
    Phosphodiesterase inhibitors and uses thereof
    The Trustees Of Columbia University In The City Of New York
    08/15/21
  1948. 378
    Piperidines as menin inhibitors
    The Regents Of The University Of Michigan
    08/15/21
  1949. 38
    Pyrazine compounds and uses thereof
    TBA
    08/15/21
  1950. 49
    Antitumor drug for intermittent administration of FGFR inhibitor
    Taiho Pharmaceutical
    08/14/21
  1951. 51
    Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors
    Nikang Therapeutics
    08/14/21
  1952. 165
    Halo-substituted piperidines as orexin receptor modulators
    Astrazeneca
    08/14/21
  1953. 648
    Heteroarylbenzimidazole compounds
    Bayer Pharma Aktiengesellschaft
    08/14/21
  1954. 35
    Heterocyclic inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    08/14/21
  1955. 19
    Indolizine derivatives, composition and methods of use
    Shanghai Fochon Pharmaceutical
    08/14/21
  1956. 161
    Inhibitors of cyclin-dependent kinases
    Kinnate Biopharma
    08/14/21
  1957. 120
    Modulators of P97 AAA ATPase activity
    University Of Pittsburgh
    08/14/21
  1958. 4
    Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
    Nanomedsyn
    08/14/21
  1959. 102
    PSMA imaging agents
    Siemens Medical Solutions Usa
    08/14/21
  1960. 3
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics
    King Abdulaziz University
    08/14/21
  1961. 46
    Substituted pyrazole derivatives as selective CDK12/13 inhibitors
    Aurigene Discovery Technologies
    08/14/21
  1962. 74
    Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof
    Jiangsu Hengrui Medicine
    08/09/21
  1963. 22
    Alpha-D-galactoside inhibitors of galectins
    Galecto Biotech
    08/09/21
  1964. 157
    Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
    Array Biopharma
    08/09/21
  1965. 14
    CGRP receptor antagonists
    Heptares Therapeutics
    08/09/21
  1966. 32
    Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
    Jiangsu Hengrui Medicine
    08/09/21
  1967. 40
    Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
    Amgen
    08/09/21
  1968. 29
    Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
    Oncozen
    08/09/21
  1969. 95
    Inhibitors of TRPC6
    Boehringer Ingelheim International
    08/09/21
  1970. 78
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland Uniservices
    08/09/21
  1971. 69
    PDE9 inhibitor and use thereof
    Nanjing Transthera Biosciences
    08/09/21
  1972. 215
    Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias
    Terns
    08/09/21
  1973. 268
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutical
    08/09/21
  1974. 52
    Tetrahydroindazoles and medical uses thereof
    Genase Therapeutics
    08/09/21
  1975. 17
    Thiazine derivatives as β-secretase inhibitors and methods of use
    Amgen
    08/09/21
  1976. 21
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    Valo Early Discovery
    08/09/21
  1977. 7
    [1,3]thiazin-2-amine compound, application, and pharmaceutical composition
    Tetranov Pharmaceutical
    08/09/21
  1978. 33
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica
    08/08/21
  1979. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute
    08/01/21
  1980. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche
    08/01/21
  1981. 61
    Cannabinergic compounds and uses thereof
    Northeastern University
    08/01/21
  1982. 48
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    08/01/21
  1983. 27
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences
    08/01/21
  1984. 3
    Kinase inhibitors
    Topivert Pharma
    08/01/21
  1985. 22
    Pharmaceutical compounds
    Sareum
    08/01/21
  1986. 16
    Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute Of Materia Medica, Chinese Academy Of Medical Sciences
    08/01/21
  1987. 137
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International
    08/01/21
  1988. 812
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    08/01/21
  1989. 19
    Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
    Ono Pharmaceutical
    08/01/21
  1990. 8
    Tyrosine kinase inhibitor and application thereof
    Lanova Medicines
    08/01/21
  1991. 25
    Compounds and their use as BACE1 inhibitors
    Allgenesis Biotherapeutics
    07/26/21
  1992. 40
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Dana-Farber Cancer Institute
    07/26/21
  1993. 138
    Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
    Shionogi
    07/26/21
  1994. 825
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics
    07/26/21
  1995. 18
    Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
    Hanmi Pharm.
    07/26/21
  1996. 10
    Zwitterionic propargyl-linked antifolates useful for treating bacterial infections
    University Of Connecticut
    07/26/21
  1997. 9
    Aminopyrazoles as selective janus kinase inhibitors
    Intervet
    07/25/21
  1998. 2
    Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
    Integrative Research Laboratories Sweden
    07/25/21
  1999. 4
    Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
    Aristea Translational Medicine
    07/25/21
  2000. 91
    Compositions and methods of modulating short-chain dehydrogenase activity
    Case Western Reserve University
    07/25/21
  2001. 23
    Compounds and methods for inhibiting CYP26 enzymes
    Queens University At Kingston
    07/25/21
  2002. 90
    Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International
    07/25/21
  2003. 174
    Factor XIIa inhibitors
    Merck Sharp & Dohme
    07/25/21
  2004. 151
    Heteroaromatic compounds as BTK inhibitors
    Boehringer Ingelheim International
    07/25/21
  2005. 3
    Highly active compounds against COVID-19
    Atea Pharmaceuticals
    07/25/21
  2006. 30
    Histone deacetylase inhibitors and uses thereof
    Musc Foundation For Research Development
    07/25/21
  2007. 26
    N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Emory University
    07/25/21
  2008. 16
    Neuroprotective agents for treatment of neurodegenerative diseases
    Wayne State University
    07/25/21
  2009. 22
    Phosphonate linkers and their use to facilitate cellular retention of compounds
    Merck Sharp & Dohme
    07/25/21
  2010. 34
    Pteridine dione monocarboxylate transporter inhibitors
    The Scripps Research Institute
    07/25/21
  2011. 25
    RIPK2 inhibitors and method of treating cancer with same
    University Health Network
    07/25/21
  2012. 102
    Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
    Sumitomo Dainippon Pharma Oncology
    07/25/21
  2013. 3
    Substituted pyrimidines for treating bacterial infections
    Forge Therapeutics
    07/25/21
  2014. 136
    Substituted pyrrolizine compounds and uses thereof
    Gilead Sciences
    07/25/21
  2015. 34
    Triazolopyridines
    Hoffmann-La Roche
    07/25/21
  2016. 23
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche
    07/25/21
  2017. 47
    2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
    Agency For Science, Technology And Research
    07/18/21
  2018. 229
    ATG7 inhibitors and the uses thereof
    Millennium Pharmaceuticals
    07/18/21
  2019. 3
    Dab2 inhibitors for the prevention and treatment of cystic fibrosis
    Trustees Of Dartmouth College
    07/18/21
  2020. 17
    Difluoroketamide derivatives as HtrA1 inhibitors
    Hoffmann-La Roche
    07/18/21
  2021. 57
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingelheim International
    07/18/21
  2022. 15
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Syros Pharmaceuticals
    07/18/21
  2023. 75
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    07/18/21
  2024. 12
    Opioid agonists and uses thereof
    Nektar Therapeutics
    07/18/21
  2025. 7
    Pet imaging agents
    Novartis
    07/18/21
  2026. 39
    Biaryl urea derivative or salt thereof and preparation process and use for the same
    Fudan University
    07/13/21
  2027. 116
    Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl
    Hoffmann-La Roche
    07/13/21
  2028. 140
    Arf6 inhibitors and methods of synthesis and use thereof
    Navigen
    07/12/21
  2029. 185
    Benzoimidazoles as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica
    07/12/21
  2030. 377
    Benzopyrazole compounds and analogues thereof
    Biocryst Pharmaceuticals
    07/12/21
  2031. 21
    Benzoxazepin oxazolidinone compounds and methods of use
    Genentech
    07/12/21
  2032. 43
    Bicyclic amines as novel JAK kinase inhibitors
    Leo Pharma
    07/12/21
  2033. 12
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    07/12/21
  2034. 64
    C3-carbon linked glutarimide degronimers for target protein degradation
    C4 Therapeutics
    07/12/21
  2035. 92
    Heterocyclic inhibitors of PTPN11
    Board Of Regents, The University Of Texas System
    07/12/21
  2036. 52
    Imidazole and triazole containing bicyclic compounds as JAK inhibitors
    Theravance Biopharma R&D Ip
    07/12/21
  2037. 30
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals
    07/12/21
  2038. 31
    Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds
    Array Biopharma
    07/12/21
  2039. 3
    Pyridine compound
    Daiichi Sankyo
    07/12/21
  2040. 227
    Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2)
    Northwestern University
    07/12/21
  2041. 7
    Substituted bicyclic heterocyclic compounds
    Bristol-Myers Squibb
    07/12/21
  2042. 118
    Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
    Celgene Quanticel Research
    07/12/21
  2043. 112
    Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
    Boehringer Ingelheim International
    07/11/21
  2044. 26
    Diarylalkanes as potent inhibitors of binuclear enzymes
    Unigen
    07/11/21
  2045. 3
    HDAC inhibitors for the treatment of diabetic peripheral neuropathy
    Regenacy Pharmaceuticals
    07/11/21
  2046. 6
    Heterocyclic ring derivatives useful as SHP2 inhibitors
    Jacobio Pharmaceuticals
    07/11/21
  2047. 53
    Heterocyclic spiro compounds as MAGL inhibitors
    Pfizer
    07/11/21
  2048. 20
    Hydantoin containing deoxyuridine triphosphatase inhibitors
    Cv6 Therapeutics (Ni
    07/11/21
  2049. 3
    Imidazopyrazine inhibitors of Bruton's tyrosine kinase
    Acerta Pharma
    07/11/21
  2050. 111
    Imidazopyrazinones as PDE1 inhibitors
    H. Lundbeck
    07/11/21
  2051. 34
    Inhibitors of phosphatidylinositol 3-kinase gamma
    Astrazeneca
    07/11/21
  2052. 22
    Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
    Temple University
    07/11/21
  2053. 5
    Oxazoline pseudodimers, pharmaceutical compositions and the use thereof
    Purdue Pharma
    07/11/21
  2054. 80
    Pyrazolopyridine derivative having GLP-1 receptor agonist effect
    Chugai Seiyaku Kabushiki Kaisha
    07/11/21
  2055. 98
    Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof
    University Of Maryland, Baltimore
    07/11/21
  2056. 119
    Triazolo-pyrimidine compounds and uses thereof
    TBA
    07/11/21
  2057. 41
    Tricyclic compounds useful to treat orthomyxovirus infections
    Novartis
    07/11/21
  2058. 16
    1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions
    Sabila Biosciences
    07/06/21
  2059. 63
    Fused amino pyridine as HSP90 inhibitors
    Curis
    07/06/21
  2060. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology
    07/06/21
  2061. 100
    Imidazopyridines Syk inhibitors
    Kronos Bio
    07/06/21
  2062. 13
    Process for preparing JAK inhibitors and intermediates thereof
    Theravance Biopharma R&D Ip
    07/06/21
  2063. 92
    Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof
    Incheon University Industry Academic Cooperation Foundation
    07/06/21
  2064. 146
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte
    07/06/21
  2065. 107
    Serine/threonine kinase inhibitors
    Genentech
    07/06/21
  2066. 271
    Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors
    Vanderbilt University
    07/06/21
  2067. 22
    Thiazolyl-containing compounds for treating proliferative diseases
    Dana-Farber Cancer Institute
    07/06/21
  2068. 359
    WDR5 inhibitors and modulators
    Vanderbilt University
    07/06/21
  2069. 12
    5 to 7 membered heterocyclic amides as JAK inhibitors
    Theravance Biopharma R&D Ip
    06/30/21
  2070. 55
    5-HT2C receptor agonists and compositions and methods of use
    Arena Pharmaceuticals
    06/30/21
  2071. 6
    6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
    Eli Lilly
    06/30/21
  2072. 73
    Acyl sulfonamide NaV1.7 inhibitors
    Bristol-Myers Squibb
    06/30/21
  2073. 57
    Bicyclic heterocyclic derivatives
    Merck Patent
    06/30/21
  2074. 58
    Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    06/30/21
  2075. 13
    Inhibitors of integrin alpha 5 beta 1 and methods of use
    The Regents Of The University Of California
    06/30/21
  2076. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda
    06/30/21
  2077. 15
    N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
    Neomed Institute
    06/30/21
  2078. 12
    Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
    Valo Early Discovery
    06/30/21
  2079. 11
    Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
    Mebias Discovery
    06/30/21
  2080. 55
    Substituted pyrrolizine compounds and uses thereof
    Gilead Sciences
    06/30/21
  2081. 50
    Therapeutic agent for FGFR inhibitor-resistant cancer
    Taiho Pharmaceutical
    06/30/21
  2082. 22
    N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
    The Regents Of The University Of Michigan
    06/29/21
  2083. 51
    2,4-pyrimidinediamine compounds and their uses
    Rigel Pharmceuticals
    06/28/21
  2084. 153
    3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives
    Gruenenthal
    06/28/21
  2085. 150
    5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis
    Galapagos
    06/28/21
  2086. 50
    Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    06/28/21
  2087. 155
    Aryl sulfonohydrazides
    Monash University
    06/28/21
  2088. 189
    Benzimidazole derivatives as modulators of ROR-gamma
    Vitae Pharmaceuticals
    06/28/21
  2089. 149
    Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors
    Boehringer Ingelheim International
    06/28/21
  2090. 23
    Compositions and methods for treating KIT- and PDGFRA-mediated diseases
    Blueprint Medicines
    06/28/21
  2091. 7
    Crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    Kronos Bio
    06/28/21
  2092. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    06/28/21
  2093. 5
    Pyridyl-triazabicycles
    Hoffmann-La Roche
    06/28/21
  2094. 82
    Pyrimidinones as PI3K inhibitors
    Incyte
    06/28/21
  2095. 22
    Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof
    Shanghai Institute Of Materia Medica, Chinese Acad
    06/28/21
  2096. 244
    Substituted 2,4-diaminopyrimidines as kinase inhibitors
    Celgene Car
    06/28/21
  2097. 111
    Substituted benzoimidazoles as modulators of ROR-γ
    Vitae Pharmaceuticals
    06/28/21
  2098. 9
    Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents
    Gi Therapeutics
    06/28/21
  2099. 108
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
    Incyte
    06/28/21
  2100. 27
    Thienopyridines and benzothiophenes useful as IRAK4 inhibitors
    Bristol-Myers Squibb
    06/28/21
  2101. 103
    Thiophene, manufacturing method thereof, and pharmaceutical application of same
    Cstone Pharmaceutical (Suzhou)
    06/28/21
  2102. 703
    Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    06/21/21
  2103. 2
    Crystal of DPP-IV long-acting inhibitor and salt
    Chia Tai Tianqing Pharmaceutical Group
    06/21/21
  2104. 30
    ErbB receptor inhibitors
    TBA
    06/21/21
  2105. 789
    Inhibitors of Bruton's tyrosine kinase and methods of their use
    Janssen Pharmaceutica
    06/21/21
  2106. 63
    KV1.3 inhibitors and their medical application
    4Sc
    06/21/21
  2107. 1
    Processes for preparing ATR inhibitors
    Vertex Pharmaceuticals
    06/21/21
  2108. 37
    Pyrazolo[1,5-a]pyrazin-4-yl derivatives
    Pfizer
    06/21/21
  2109. 12
    Pyrazolopyrimidine derivatives as NIK inhibitors
    Janssen Pharmaceutica
    06/21/21
  2110. 74
    Substituted aminoquinazoline compounds as A2A antagonist
    Merck Sharp & Dohme
    06/21/21
  2111. 797
    Compounds that inhibit Mcl-1 protein
    Amgen
    06/20/21
  2112. 10
    Isoidide derivatives and methods of making and using same
    Rutgers, The State University Of New Jersey
    06/14/21
  2113. 10
    Optically active azabicyclo ring derivative
    Sumitomo Dainippon Pharma
    06/14/21
  2114. 31
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
    Respivert
    06/13/21
  2115. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Bayer Aktiengesellschaft
    06/13/21
  2116. 325
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    06/13/21
  2117. 140
    Bruton's tyrosine kinase inhibitors
    Pfizer
    06/13/21
  2118. 4
    Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
    Institute Of Materia Medica, Chinese Academy Of Medical Sciences
    06/13/21
  2119. 90
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals
    06/13/21
  2120. 107
    Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
    Incyte
    06/13/21
  2121. 17
    Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
    Pfizer
    06/13/21
  2122. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck
    06/11/21
  2123. 382
    3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GrüNenthal
    06/11/21
  2124. 289
    3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GrÜNenthal
    06/11/21
  2125. 104
    Bromodomain inhibitors
    Celgene Quanticel Research
    06/11/21
  2126. 59
    Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    Merck Sharp & Dohme
    06/11/21
  2127. 124
    Compositions useful for treating disorders related to kit
    Blueprint Medicines
    06/11/21
  2128. 101
    Compounds for treatment of immune inflammatory disorders
    Achillion Pharmaceuticals
    06/11/21
  2129. 51
    Dihydrochromene derivatives
    Sumitomo Dainippon Pharma
    06/11/21
  2130. 156
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    06/11/21
  2131. 200
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    06/11/21
  2132. 42
    HDAC inhibitor compounds and methods of treatment
    University Of Florida Research Foundation
    06/11/21
  2133. 97
    Heterocyclic compounds and uses thereof
    Nuvation Bio
    06/11/21
  2134. 16
    Heterocyclic compounds as kinase inhibitors
    Translational Drug Development
    06/11/21
  2135. 191
    Immunomodulator compounds and methods of use
    Incyte
    06/11/21
  2136. 161
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    The Institute Of Cancer Research: Royal Cancer Hospital
    06/11/21
  2137. 28
    Protease inhibitors having enhanced features
    Nektar Therapeutics
    06/11/21
  2138. 17
    Pyrrolidinone compounds
    Eli Lilly
    06/11/21
  2139. 51
    Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    University Of Tennessee Research Foundation
    06/11/21
  2140. 42
    Spiro-cyclic amine derivatives as S1P modulators
    Abbvie
    06/11/21
  2141. 260
    WDR5-MLL1 inhibitors and modulators
    Vanderbilt University
    06/11/21
  2142. 38
    2,6-disubstituted pyridine derivative
    Sumitomo Dainippon Pharma
    06/01/21
  2143. 20
    4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors
    Nerviano Medical Sciences
    06/01/21
  2144. 155
    5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
    Leo Pharma
    06/01/21
  2145. 20
    Arylpropionyl-triketone antibacterial agents
    TBA
    06/01/21
  2146. 40
    Beta-lactamase inhibitor compounds
    Entasis Therapeutics
    06/01/21
  2147. 32
    Bicyclic compounds as ATX inhibitors
    Hoffman-La Roche
    06/01/21
  2148. 219
    CDK2/4/6 inhibitors
    Pfizer
    06/01/21
  2149. 105
    Carboxamide compounds and uses thereof
    Incyte
    06/01/21
  2150. 22
    Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor
    TBA
    06/01/21
  2151. 7
    Conjugate comprising a neurotensin receptor ligand and use thereof
    3B Pharmaceuticals
    06/01/21
  2152. 25
    Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    06/01/21
  2153. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte
    06/01/21
  2154. 266
    Heterocyclic compounds as immunomodulators
    Incyte
    06/01/21
  2155. 122
    Heterocyclic inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    06/01/21
  2156. 32
    Heterocyclic inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    06/01/21
  2157. 12
    Hybrid galactoside inhibitor of galectins
    TBA
    06/01/21
  2158. 41
    Imidazole derivatives as formyl peptide receptor modulators
    Allergan
    06/01/21
  2159. 62
    Indole derivative used as CRTH2 inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    06/01/21
  2160. 912
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica
    06/01/21
  2161. 94
    Inhibitors of TRPC6
    Boehringer Ingelheim International
    06/01/21
  2162. 9
    Methotrexate adjuvants to reduce toxicity and methods for using the same
    Tosk
    06/01/21
  2163. 123
    Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof
    Japan Tobacco
    06/01/21
  2164. 11
    Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
    Bayer Pharma Aktiengesellschaft
    06/01/21
  2165. 7
    Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
    Aclaris Therapeutics
    06/01/21
  2166. 6
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica
    06/01/21
  2167. 85
    Substituted pyrrolo[2,3-d]pyridazin-4-ones and pyrazolo[3,4-d]pyridazin-4-ones as protein kinase inhibitors
    Shanghai Fochon Pharmaceutical
    06/01/21
  2168. 7
    Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders
    Northwestern University
    06/01/21
  2169. 36
    Thyroid hormone receptor beta agonist compounds
    Terns
    06/01/21
  2170. 179
    Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
    Allergan
    06/01/21
  2171. 2
    1,8-naphthyridinone compounds and uses thereof
    Nuvation Bio
    05/14/21
  2172. 73
    3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GrÜNenthal
    05/14/21
  2173. 34
    8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    Gruenenthal
    05/14/21
  2174. 144
    Amino acid compounds and methods of use
    Pliant Therapeutics
    05/14/21
  2175. 3
    Amino pyrimidine ssao inhibitors
    Eli Lilly
    05/14/21
  2176. 84
    Bicyclic heterocyclic compound
    Mitsubishi Tanabe Pharma
    05/14/21
  2177. 15
    Bicyclic inhibitors of histone deacetylase
    Rodin Therapeutics
    05/14/21
  2178. 361
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer
    05/14/21
  2179. 123
    Bruton's tyrosine kinase inhibitors
    Zibo Biopolar Changsheng Pharmaceutical
    05/14/21
  2180. 126
    Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof
    Chengdu Brilliant Pharmaceutical
    05/14/21
  2181. 502
    GCN2 inhibitors and uses thereof
    Merck Patent
    05/14/21
  2182. 19
    Glutamine transport inhibitors and methods for treating cancer
    Vanderbilt University
    05/14/21
  2183. 4
    Heterocyclic compounds as immunomodulators
    Incyte
    05/14/21
  2184. 45
    Heterocyclic glutaminase inhibitors
    Calithera Biosciences
    05/14/21
  2185. 336
    Hormone receptor modulators for treating metabolic conditions and disorders
    Ardelyx
    05/14/21
  2186. 59
    Oxoisoquinoline derivatives
    Carna Biosciences
    05/14/21
  2187. 7
    Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
    Hangzhou Zhengxiang Pharmaceuticals
    05/14/21
  2188. 22
    Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
    Bayer Pharma Aktiengesellschaft
    05/14/21
  2189. 15
    Substituted nucleosides, nucleotides and analogs thereof
    Janssen Biopharma
    05/14/21
  2190. 310
    Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
    Leo Pharma
    05/14/21
  2191. 4
    Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators
    Arena Pharmaceuticals
    05/14/21
  2192. 59
    Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof
    Shanghai Haiyan Pharmaceutical Technology
    05/14/21
  2193. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    05/14/21
  2194. 555
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    05/11/21
  2195. 56
    ASK1 inhibitor and preparation method and use thereof
    Fuijan Cosunter Pharmaceutical
    05/09/21
  2196. 9
    Benzopiperdine derivatives and their use in the treatment of cancer and hemoglobinopathies
    Ctxt
    05/09/21
  2197. 3
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche
    05/09/21
  2198. 90
    Cannabinoid receptor mediating iminopyrazole compounds
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    05/09/21
  2199. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    05/09/21
  2200. 40
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Dana-Farber Cancer Institute
    05/09/21
  2201. 2
    Octahydropyrrolopyrroles their preparation and use
    The Trustees Of Columbia University In The City Of New York
    05/09/21
  2202. 23
    Prodrugs of pyridone amides useful as modulators of sodium channels
    Vertex Pharmaceuticals
    05/09/21
  2203. 253
    Spiro-fused cyclic ureas as inhibitors of rock
    Bristol-Myers Squibb
    05/09/21
  2204. 18
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer
    05/09/21
  2205. 105
    Thiazolidinedione derivative and use thereof
    Industry-Academic Cooperation Foundation Chosun University
    05/09/21
  2206. 93
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    05/03/21
  2207. 2
    2,6-diamino pyridine compounds
    Eli Lilly
    05/03/21
  2208. 4
    3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    05/03/21
  2209. 10
    Azetidinyloxyphenylpyrrolidine compounds
    Eli Lilly
    05/03/21
  2210. 6
    Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
    AchÉ
    05/03/21
  2211. 108
    Heterocyclic compounds for the inhibition of PASK
    Bioenergenix
    05/03/21
  2212. 108
    N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    Kalvista Pharmaceuticals
    05/03/21
  2213. 260
    Spirocycle compounds and methods of making and using same
    Lundbeck La Jolla Research Center
    05/03/21
  2214. 163
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    05/03/21
  2215. 137
    Therapeutic inhibitory compounds
    Attune Pharmaceuticals
    05/03/21
  2216. 25
    Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists
    The Regents Of The University Of California
    05/02/21
  2217. 151
    Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
    Merck Sharp & Dohme
    05/02/21
  2218. 352
    Heteroaryl compounds useful as inhibitors of SUMO activating enzyme
    Millennium Pharmaceuticals
    05/02/21
  2219. 3
    Macrocycle and composition comprising thereof
    Shenzhen Targetrx
    05/02/21
  2220. 7
    Mu opioid receptor modulators
    The Regents Of The University Of California
    05/02/21
  2221. 287
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    05/02/21
  2222. 242
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck
    04/26/21
  2223. 83
    2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
    Array Biopharma
    04/26/21
  2224. 9
    Aminopyrazoles as janus kinase inhibitors
    Merck Sharp & Dohme
    04/26/21
  2225. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    Novartis
    04/26/21
  2226. 137
    Cyclin dependent kinase inhibitors
    Pfizer
    04/26/21
  2227. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    Proximagen
    04/26/21
  2228. 106
    Morphinan derivatives for the treatment of neuropathic pain
    Nektar Therapeutics
    04/26/21
  2229. 243
    Piperidine derivatives as inhibitors of ubiquitin specific protease 7
    Almac Discovery
    04/26/21
  2230. 19
    Substituted benzamides and methods of use thereof
    Genentech
    04/26/21
  2231. 33
    Sulfonylcycloalkyl carboxamide compounds
    Genentech
    04/26/21
  2232. 43
    Trk-inhibiting compound
    Ono Pharmaceutical
    04/26/21
  2233. 96
    Wee-1 inhibiting pyrazolopyrimidinone compounds
    Almac Discovery
    04/26/21
  2234. 22
    1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    Novartis
    04/25/21
  2235. 432
    2-(morpholin-4-yl)-1,7-naphthyridines
    Bayer Pharma Aktiengesellschaft
    04/25/21
  2236. 39
    2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
    Blueprint Medicines
    04/25/21
  2237. 1204
    6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
    Shionogi
    04/25/21
  2238. 123
    Composition and methods for inhibiting mammalian sterile 20-like kinase 1
    The Scripps Research Institute
    04/25/21
  2239. 3
    Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
    Pharmakea
    04/25/21
  2240. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences
    04/25/21
  2241. 106
    Galactoside inhibitor of galectins
    Galecto Biotech
    04/25/21
  2242. 352
    HIV protease inhibitors
    Gilead Sciences
    04/25/21
  2243. 191
    Heteroaryl compounds and uses thereof
    Celgene Car
    04/25/21
  2244. 54
    Indazole compounds and uses thereof
    Incyte
    04/25/21
  2245. 24
    Materials and method for inhibiting replication protein A and uses thereof
    Indiana University Research And Technology
    04/25/21
  2246. 105
    Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    Array Biopharma
    04/25/21
  2247. 381
    PD-1/PD-L1 inhibitors
    Gilead Sciences
    04/25/21
  2248. 71
    Substituted piperazines as selective HDAC1,2 inhibitors
    Regenacy Pharmaceuticals
    04/25/21
  2249. 343
    ULK1 inhibitors and methods using same
    Salk Institute For Biological Studies
    04/25/21
  2250. 43
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    04/19/21
  2251. 20
    Indazole containing macrocycles and therapeutic uses thereof
    Samumed
    04/19/21
  2252. 220
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    04/19/21
  2253. 15
    Thienopyrimidine derivative and use thereof in medicine
    Sunshine Lake Pharma
    04/19/21
  2254. 106
    2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors
    Almirall
    04/18/21
  2255. 77
    2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
    Bayer Pharma Aktiengesellschaft
    04/18/21
  2256. 33
    Benzofuran derivative, preparation method thereof and use thereof in medicine
    Jiangsu Hengrui Medicine
    04/18/21
  2257. 138
    CXCR4 inhibitors and uses thereof
    X4 Pharmaceuticals
    04/18/21
  2258. 26
    CaMKII inhibitors and uses thereof
    The Johns Hopkins University
    04/18/21
  2259. 138
    Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
    Synchronicity Pharma
    04/18/21
  2260. 20
    Carboxamide derivatives useful as rsk inhibitors
    Phoenix Molecular Designs
    04/18/21
  2261. 32
    Certain chemical entities, compositions, and methods
    Neupharma
    04/18/21
  2262. 46
    Glucosylceramide synthase inhibitors for the treatment of diseases
    TBA
    04/18/21
  2263. 24
    Mammalian and bacterial nitric oxide synthase inhibitors
    Northwestern University
    04/18/21
  2264. 2
    Pharmaceutical uses of pyridine carboxamide derivatives
    Jiangsu Hengrui Medicine
    04/18/21
  2265. 232
    Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array Biopharma
    04/18/21
  2266. 7
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals
    04/18/21
  2267. 8
    1,3,5-triazine derivative and method of using same
    Chia Tai Tianqing Pharmaceutical Group
    04/13/21
  2268. 66
    6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
    Samumed
    04/13/21
  2269. 6
    Adenosine A3 receptor modulators
    Palobiofarma
    04/13/21
  2270. 19
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    04/13/21
  2271. 190
    Condensed lactam derivative
    Sumitomo Dainippon Pharma
    04/13/21
  2272. 57
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent
    04/13/21
  2273. 16
    Indazole compounds and uses thereof
    Incyte
    04/13/21
  2274. 2
    Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
    Ctxt
    04/13/21
  2275. 18
    Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents
    Zenji Research Laboratories
    04/13/21
  2276. 420
    Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
    Lycera
    04/13/21
  2277. 96
    Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    04/13/21
  2278. 40
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    04/12/21
  2279. 5
    PPARG modulators for the treatment of osteoporosis
    The Scripps Research Institute
    04/12/21
  2280. 75
    4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
    Eastern Virginia Medical School
    04/11/21
  2281. 6
    6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds
    Eli Lilly
    04/11/21
  2282. 20
    Aryldiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals
    04/11/21
  2283. 46
    Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
    King''S College London
    04/11/21
  2284. 20
    C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
    Je Ii Pharmaceutical
    04/11/21
  2285. 15
    Compounds and their use for reducing uric acid levels
    Acquist
    04/11/21
  2286. 27
    Dopamine D2 receptor ligands
    The Broad Institute
    04/11/21
  2287. 62
    Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
    Xenon Pharmaceuticals
    04/11/21
  2288. 12
    Heterocyclic compounds as FGFR inhibitors
    Guangzhou Innocare Pharma Tech
    04/11/21
  2289. 25
    Iso-citrate dehydrogenase (IDH) inhibitor
    Shanghai Meton Pharmaceutical
    04/11/21
  2290. 38
    Morphan and morphinan analogues, and methods of use
    Alkermes Pharma Ireland
    04/11/21
  2291. 152
    Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
    Japan Tobacco
    04/11/21
  2292. 28
    Signaling-biased mu opioid receptor agonists
    The Scripps Research Institute
    04/11/21
  2293. 148
    Spirocyclic containing compounds and pharmaceutical uses thereof
    Gb005
    04/11/21
  2294. 14
    Substituted aminopyrimidine compounds and methods of use
    Sunshine Lake Pharma
    04/11/21
  2295. 42
    1,3-diaza-spiro-[3.4]-octane derivatives
    GrÜNenthal
    04/04/21
  2296. 64
    6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
    Pfizer
    04/04/21
  2297. 97
    Amide compounds as kinase inhibitors, compositions and methods of treatment
    Translation Drug Development
    04/04/21
  2298. 33
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences
    04/04/21
  2299. 96
    Benzimidazole derivatives: preparation and pharmaceutical applications
    Mei Pharma
    04/04/21
  2300. 4
    Bicyclic compounds as dual ATX/CA inhibitors
    Hoffmann-La Roche
    04/04/21
  2301. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    04/04/21
  2302. 29
    Cyclic di-nucleotide compounds as STING agonists
    Merck Sharp & Dohme
    04/04/21
  2303. 204
    Imidazotriaines and imidazopyrimidines as kinase inhibitors
    Incyte Holdings
    04/04/21
  2304. 11
    Isoquinoline derivatives and use thereof
    Purdue Pharma
    04/04/21
  2305. 37
    Methods for treating depressive symptoms
    Alkermes Pharma Ireland
    04/04/21
  2306. 508
    Pyrazolopyrimidinone compounds and uses thereof
    Aduro Biotech
    04/04/21
  2307. 158
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    04/04/21
  2308. 35
    Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
    The Johns Hopkins University
    04/04/21
  2309. 118
    Tertiary alcohols as PI3K-γ inhibitors
    Incyte
    04/04/21
  2310. 315
    Triazole furan compounds as agonists of the APJ receptor
    Amgen
    04/04/21
  2311. 242
    Biphenyl compound or salt thereof
    Taiho Pharmaceutical
    03/30/21
  2312. 5
    1,1 ′-sulfanediyl-di-beta-D-galactopyranosides as inhibitors of galectins
    Galecto Biotech
    03/28/21
  2313. 380
    Amido spirocyclic amide and sulfonamide derivatives
    Forma Tm
    03/28/21
  2314. 230
    Biaryl kinase inhibitors
    Bristol-Myers Squibb
    03/28/21
  2315. 51
    Cyanoindazole compounds and uses thereof
    Incyte
    03/28/21
  2316. 4
    Cyclodextrin-panobinostat adduct
    Midatech
    03/28/21
  2317. 10
    D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof
    Peking University
    03/28/21
  2318. 204
    Heterocyclic compounds and uses thereof
    Incyte
    03/28/21
  2319. 6
    Protease inhibitors
    Medivir
    03/28/21
  2320. 173
    Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors
    Bristol-Myers Squibb
    03/28/21
  2321. 34
    2-aminoquinazoline derivatives as P70S6 kinase inhibitors
    Sentinel Oncology
    03/27/21
  2322. 199
    4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors
    Array Biopharma
    03/27/21
  2323. 841
    4-Azaindole compounds
    Bristol-Myers Squibb
    03/27/21
  2324. 95
    Bicyclic heteroaryl substituted compounds
    Bristol-Myers Squibb
    03/27/21
  2325. 140
    Compounds and methods for the enhanced degradation of targeted proteins
    Arvinas Operations
    03/27/21
  2326. 49
    Compounds for modulating aquaporins
    Apoglyx
    03/27/21
  2327. 2
    Diaminopyrimidine benzenesulfone derivatives and uses thereof
    Dana-Farber Cancer Institute
    03/27/21
  2328. 28
    Fused pyrimidine derivatives
    Hoffmann-La Roche
    03/27/21
  2329. 72
    Indole derivatives and use thereof
    Purdue Pharma
    03/27/21
  2330. 311
    Inhibitors of plasma kallikrein and uses thereof
    Shire Human Genetic Therapies
    03/27/21
  2331. 31
    Substituted imidazo[1,2-A]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof
    Jn Therapeutics
    03/27/21
  2332. 63
    5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
    Bayer Pharma Aktiengesellschaft
    03/21/21
  2333. 130
    Aliphatic prolinamide derivatives
    Orion Ophthalmology
    03/21/21
  2334. 12
    Alkynyl dihydroquinoline sulfonamide compounds
    Amgen
    03/21/21
  2335. 29
    Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof
    The Research Foundation For The State University Of New York
    03/21/21
  2336. 12
    Benzimidazole derivatives as EP4 ligands
    Bayer Pharma Aktiengesellschaft
    03/21/21
  2337. 51
    Benzo[b]thiophene compounds as STING agonists
    Merck Sharp & Dohme
    03/21/21
  2338. 427
    Bridged bicyclic compounds as farnesoid X receptor modulators
    Bristol-Myers Squibb
    03/21/21
  2339. 6
    Catecholamine prodrugs for use in the treatment of Parkinson's disease
    H. Lundbeck
    03/21/21
  2340. 86
    Chemical compounds
    Astrazeneca
    03/21/21
  2341. 17
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    Xw Laboratories
    03/21/21
  2342. 115
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    03/21/21
  2343. 116
    Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis
    03/21/21
  2344. 44
    Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis
    03/21/21
  2345. 17
    Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
    University Health Network
    03/21/21
  2346. 66
    Ketone inhibitors of lysine gingipain
    Cortexyme
    03/21/21
  2347. 31
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb
    03/21/21
  2348. 106
    Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
    Boehringer Ingelheim International
    03/21/21
  2349. 29
    Pyrimidinone and its derivatives inhibiting factor XIa
    Ono Pharmaceutical
    03/21/21
  2350. 137
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International
    03/21/21
  2351. 9
    Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
    Wisconsin Alumni Research Foundation
    03/21/21
  2352. 25
    Tetrahydronaphthalene derivative
    Ono Pharmaceutical
    03/21/21
  2353. 207
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals
    03/21/21
  2354. 59
    Treatment of infectious diseases with glucose uptake inhibitors
    Kadmon
    03/21/21
  2355. 87
    MALT1 inhibitors and uses thereof
    Cornell University
    03/15/21
  2356. 28
    Selective Bruton's tyrosine kinase inhibitor and use thereof
    Hangzhou Hertz Pharmaceutical
    03/15/21
  2357. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics
    03/15/21
  2358. 783
    Tricyclic sulfones as RORγ modulators
    Bristol-Myers Squibb
    03/15/21
  2359. 16
    Agent for treating synucleinopathy
    Tohoku University
    03/14/21
  2360. 88
    Aminopyridine derivatives and their use as selective ALK-2 inhibitors
    Novartis
    03/14/21
  2361. 1072
    Biaryl amide compounds as kinase inhibitors
    Novartis
    03/14/21
  2362. 2
    Compounds as rearranged during transfection (RET) inhibitors
    Glaxosmithkline Intellectual Property Development
    03/14/21
  2363. 28
    Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
    Metabasis Therapeutics
    03/14/21
  2364. 150
    Oxadiazole transient receptor potential channel inhibitors
    Genentech
    03/14/21
  2365. 275
    Oxadiazole transient receptor potential channel inhibitors
    Genentech
    03/14/21
  2366. 656
    PD-1/PD-L1 inhibitors
    Gilead Sciences
    03/14/21
  2367. 294
    Pyrimidine derivative
    Aska Pharmaceutical
    03/14/21
  2368. 59
    STK4 inhibitors for treatment of hematologic malignancies
    Dana-Farber Cancer Institute
    03/14/21
  2369. 10
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    03/14/21
  2370. 203
    Substituted carbonucleoside derivatives useful as anticancer agents
    Pfizer
    03/14/21
  2371. 17
    3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA
    Novartis
    03/11/21
  2372. 43
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University Of The Commonwealth System Of Higher Education
    03/11/21
  2373. 11
    Antidiabetic bicyclic compounds
    Merch Sharp & Dohne Corp. Rahway
    03/11/21
  2374. 58
    Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
    Washington University
    03/11/21
  2375. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    03/11/21
  2376. 94
    GLP-1 receptor agonists and uses thereof
    Pfizer
    03/11/21
  2377. 118
    Imidazolepyridine compounds and uses thereof
    Novartis
    03/11/21
  2378. 34
    Inhibitors of lysine gingipain
    Cortexyme
    03/11/21
  2379. 182
    Kappa opioid receptor antagonists and products and methods related thereto
    Blackthorn Therapeutics
    03/11/21
  2380. 53
    Macrocyclic MCL-1 inhibitors and methods of use
    Abbvie
    03/11/21
  2381. 3
    Quinazolines as potassium ion channel inhibitors
    Bristol-Myers Squibb
    03/11/21
  2382. 14
    Small-molecule HSP90 inhibitors
    Sloan-Kettering Institute For Cancer Research
    03/11/21
  2383. 190
    Bicyclic quinazolinone derivatives
    Hoffmann-La Roche
    03/10/21
  2384. 178
    Carbazole derivatives
    Bristol-Myers Squibb
    03/10/21
  2385. 109
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    03/10/21
  2386. 196
    Indole derivatives and their use in neurodegenerative diseases
    Merck Patent
    03/10/21
  2387. 10
    KCNQ2-5 channel activator
    Ono Pharmaceutical
    03/10/21
  2388. 127
    Phenylpyrrolidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb
    03/10/21
  2389. 169
    Somatostatin receptor subtype 4 (SSTR4) agonists
    Centrexion Therapeutics
    03/10/21
  2390. 37
    Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
    Incyte
    03/10/21
  2391. 7
    Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof
    Leo Pharma
    03/08/21
  2392. 16
    Covalent inhibitors of PAD4
    Padlock Therapeutics
    03/08/21
  2393. 21
    Degradation of tripartite motif-containing protein 24 (TRIM24) by conjugation of TRIM24 inhibitors with E3 ligase ligand and methods of use
    Dana-Farber Cancer Institute
    03/08/21
  2394. 445
    MCL-1 inhibitors
    Gilead Sciences
    03/08/21
  2395. 15
    MU opioid receptor modulators
    The Regents Of The University Of California
    03/08/21
  2396. 289
    P2X7 modulators
    Janssen Pharmaceutica
    03/08/21
  2397. 1
    Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    Galapagos
    03/08/21
  2398. 14
    Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    Neomed Institute
    03/08/21
  2399. 337
    Substituted purine derivative
    Sumitomo Dainippon Pharma
    03/08/21
  2400. 308
    Amido-benzyl sulfone and sulfoxide derivates
    TBA
    03/02/21
  2401. 152
    Amino acid compounds and methods of use
    Pliant Therapeutics
    03/02/21
  2402. 44
    CDK inhibitors
    G1 Therapeutics
    03/02/21
  2403. 69
    Compounds
    Exonate
    03/02/21
  2404. 43
    Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same
    Industrial Technology Research Institute
    03/02/21
  2405. 57
    Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
    Boehringer Ingelheim International
    03/02/21
  2406. 64
    Kinase inhibitor, and preparing method and pharmaceutical use thereof
    Gan & Lee Pharmaceuticals
    03/02/21
  2407. 23
    Mutant IDH1 inhibitors
    Eli Lilly
    03/02/21
  2408. 388
    Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
    Incyte Holdings
    03/02/21
  2409. 40
    Pyrimidine derivative and use thereof
    Hubei Bio-Pharmaceutical Industrial Technological Institute
    03/02/21
  2410. 36
    Rho kinase inhibitors
    Kadmon
    03/02/21
  2411. 23
    Somatostatin modulators and uses thereof
    Crinetics Pharmaceuticals
    03/02/21
  2412. 125
    Therapeutic compounds and uses thereof
    Genentech
    03/02/21
  2413. 149
    1,2-substituted cyclopentanes as orexin receptor antagonists
    Takeda Pharmaceutical
    02/22/21
  2414. 269
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics
    02/22/21
  2415. 25
    C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    02/22/21
  2416. 71
    FGFR3 fusion gene and pharmaceutical drug targeting same
    Chugai Seiyaku Kabushiki Kaisha
    02/22/21
  2417. 246
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    02/22/21
  2418. 13
    Macrocylic compounds as ROS1 kinase inhibitors
    Array Biopharma
    02/22/21
  2419. 647
    Methods, compositions, and uses of novel Fyn kinase inhibitors
    TBA
    02/22/21
  2420. 43
    N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof
    Northeastern University
    02/22/21
  2421. 89
    OXA-Diazaspiro compounds having activity against pain
    Esteve Pharmaceuticals
    02/22/21
  2422. 64
    Piperazine-substituted benzothiophenes for treatment of mental disorders
    Otsuka Pharmaceutical
    02/22/21
  2423. 15
    Prodrug amino acid derivative
    Taisho Pharmaceutical
    02/22/21
  2424. 69
    Pyrrolidine derivatives
    Hoffmann-La Roche
    02/22/21
  2425. 124
    Quinoxaline compounds as type III receptor tyrosine kinase inhibitors
    Development Center For Biotechnology
    02/22/21
  2426. 23
    Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections
    Gilead Sciences
    02/22/21
  2427. 127
    Substituted indazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    02/22/21
  2428. 39
    Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
    Stingray Therapeutics
    02/22/21
  2429. 206
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals
    02/22/21
  2430. 233
    Triazole pyridyl compounds as agonists of the APJ receptor
    Amgen
    02/22/21
  2431. 18
    Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer
    Jubilant Biosys
    02/22/21
  2432. 14
    Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
    Jubilant Biosys
    02/22/21
  2433. 242
    5-substituted indazole-3-carboxamides and preparation and use thereof
    Samumed
    02/21/21
  2434. 115
    Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    1St Biotherapeutics
    02/21/21
  2435. 306
    Bicyclic derivatives
    Hoffmann-La Roche
    02/21/21
  2436. 104
    Boronic acid derivatives
    Merck Patent
    02/21/21
  2437. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    02/21/21
  2438. 43
    Condensed [1,4] diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffmann-La Roche
    02/21/21
  2439. 48
    Fused pyrimidine derivatives
    Hoffmann-La Roche
    02/21/21
  2440. 30
    Heterocyclic compounds as immunomodulators
    Incyte
    02/21/21
  2441. 104
    Imidazopyridazine compounds
    Pfizer
    02/21/21
  2442. 10
    Isoxazole carboxamides as irreversible SMYD inhibitors
    Epizyme
    02/21/21
  2443. 4
    LXR agonists and uses thereof
    Rgenix
    02/21/21
  2444. 72
    Pyridyl benzothiophenes as kinase inhibitors
    Allergan
    02/21/21
  2445. 39
    Substituted N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and N-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives P2X7 receptor antagonists
    Axxam
    02/21/21
  2446. 36
    Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
    Peking University
    02/21/21
  2447. 67
    5-5 fused rings as C5a inhibitors
    Chemocentryx
    02/16/21
  2448. 29
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda
    02/16/21
  2449. 3
    Heterocyclic compounds for the treatment of disease
    Oppilan Pharma
    02/16/21
  2450. 80
    Tricyclic compounds as anticancer agents
    Bristol-Myers Squibb
    02/16/21
  2451. 42
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    Max-DelbrÜCk-Centrum FÜR Molekulare Medizin
    02/16/21
  2452. 100
    (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
    Bayer Pharma Aktiengesellschaft
    02/15/21
  2453. 17
    (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using
    Iowa State University Research Foundation
    02/15/21
  2454. 68
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    02/15/21
  2455. 23
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    02/15/21
  2456. 100
    Compound having mutant IDH inhibitory activity, preparation method and use thereof
    Shanghai Haihe Pharmaceutical
    02/15/21
  2457. 9
    Curcumin analogues as zinc chelators and their uses
    The Research Foundation Of State University Of New York
    02/15/21
  2458. 147
    Cyanopyrrolidines as dub inhibitors for the treatment of cancer
    Mission Therapeutics
    02/15/21
  2459. 62
    Glucocorticoid receptor agonist and immunoconjugates thereof
    Abbvie
    02/15/21
  2460. 45
    Heterocyclic derivatives and their use in the treatment of neurological disorders
    Novartis
    02/15/21
  2461. 55
    Indole derivatives and their use as protein kinase inhibitors
    Respivert
    02/15/21
  2462. 56
    Modulators of calcium release-activated calcium channel
    Rhizen Pharmaceuticals
    02/15/21
  2463. 4
    Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    02/15/21
  2464. 135
    Pyridine sulfonamides
    Amgen
    02/15/21
  2465. 21
    Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Yeda Research And Development
    02/15/21
  2466. 68
    Tetrahydronaphthyl urea derivative
    Mochida Pharmaceutical
    02/15/21
  2467. 841
    Pyridyl substituted indole compounds
    Bristol-Myers Squibb
    02/08/21
  2468. 60
    ABHD6 and dual ABHD6/MGL inhibitors and their uses
    Makscientific
    02/07/21
  2469. 89
    Amino compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    02/07/21
  2470. 83
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    02/07/21
  2471. 27
    Benzimidazole derivatives as PI3 kinase inhibitors
    Glaxosmithkline
    02/07/21
  2472. 124
    Bruton's tyrosine kinase inhibitors
    Zibo Biopolar Changsheng Pharmaceutical
    02/07/21
  2473. 90
    Guanidine derivative and medical use thereof
    Toray Industries
    02/07/21
  2474. 78
    PDE4 inhibitor
    Shijiazhuang Sagacity New Drug Development
    02/07/21
  2475. 137
    Substituted pyrimidines as cyclin-dependent kinase inhibitors
    Shanghai Pharmaceuticals Holding
    02/07/21
  2476. 90
    ASK1 isoindolin-1-one inhibitors and methods of use thereof
    Hepatikos Therapeutics
    02/01/21
  2477. 7
    Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffman-La Roche
    02/01/21
  2478. 69
    Compounds and methods for inhibiting JAK
    Dizal (Jiangsu) Pharmaceutical
    02/01/21
  2479. 17
    Method for preparing pyrrolo[3,2-D]pyrimidine compound, and intermediates thereof
    Chia Tai Tianqing Pharmaceutical Group
    02/01/21
  2480. 73
    Protein kinase B inhibitors
    Astrazeneca
    02/01/21
  2481. 10
    Pyrimidine derivative, method for preparing same and use thereof in medicine
    Zhejiang Hisun Pharmaceutical
    02/01/21
  2482. 21
    Selective estrogen receptor degraders
    Eli Lilly
    02/01/21
  2483. 145
    Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
    Mission Therapeutics
    02/01/21
  2484. 31
    Tricyclic rho kinase inhibitors
    Bristol-Myers Squibb
    02/01/21
  2485. 143
    6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    01/31/21
  2486. 14
    Antiproliferative pyrimidine-based compounds
    G1 Therapeutics
    01/31/21
  2487. 127
    Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity
    Kancera
    01/31/21
  2488. 52
    Substituted quinazolines for inhibiting kinase activity
    Neupharma
    01/31/21
  2489. 33
    Biaryl urea derivative or salt thereof and preparation process and use for the same
    Fudan University
    01/25/21
  2490. 5
    Bicyclic compounds as dual ATX/CA inhibitors
    Hoffmann-La Roche
    01/25/21
  2491. 14
    Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies
    Galderma Research & Development
    01/25/21
  2492. 40
    Diphenylaminopyrimidine and triazine compound, and pharmaceutical composition and use thereof
    Arromax Pharmatech
    01/25/21
  2493. 14
    EZH2 inhibitor and use thereof
    Tarapeutics Science
    01/25/21
  2494. 3
    Heterocyclic degronimers for target protein degradation
    C4 Therapeutics
    01/25/21
  2495. 342
    Heterocyclylamines as PI3K inhibitors
    Incyte
    01/25/21
  2496. 333
    Pyrimido-pyridazinone compounds and methods of use thereof
    Asan Biosciences
    01/25/21
  2497. 47
    Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    01/25/21
  2498. 50
    Substituted pyrimidines for preventing or treating cancer and inflammatory diseases
    Korea Research Institute Of Chemical Technology
    01/25/21
  2499. 601
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    01/25/21
  2500. 46
    Tetrahydroisoquinoline derived PRMT5-inhibitors
    Ctxt
    01/25/21
  2501. 172
    Alkoxy compounds for disease treatment
    Acucela
    01/18/21
  2502. 68
    Compounds
    Mission Therapeutics
    01/18/21
  2503. 19
    Epoxyketone compounds for enzyme inhibition
    Centrax International
    01/18/21
  2504. 85
    Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
    Boehringer Ingelheim International
    01/18/21
  2505. 615
    Heterocycle derivatives having TrkA inhibitory activity
    Shionogi
    01/18/21
  2506. 158
    Imidazopyridines and imidazopyrazines as LSD1 inhibitors
    Incyte
    01/18/21
  2507. 312
    Immunomodulator compounds
    Chemocentryx
    01/18/21
  2508. 20
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche
    01/18/21
  2509. 205
    Therapeutically active compositions and their methods of use
    Agios Pharmaceuticals
    01/18/21
  2510. 113
    Diazaspirocycloalkane and azaspirocycloalkane
    Hoffmann-La Roche
    01/12/21
  2511. 168
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    01/10/21
  2512. 130
    Bromodomain inhibitors
    Abbvie
    01/10/21
  2513. 1023
    CARM1 inhibitors and uses thereof
    Epizyme
    01/10/21
  2514. 115
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases
    University Of Washington
    01/10/21
  2515. 248
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    01/10/21
  2516. 130
    Melanocortin receptor-specific peptides
    Palatin Technologies
    01/10/21
  2517. 16
    Methods to treat lymphoplasmacytic lymphoma
    Dana-Farber Cancer Institute
    01/10/21
  2518. 107
    Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
    Jinagsu Hengrui Medicine
    01/10/21
  2519. 14
    Pyrazolopyrimidone derivatives and methods of use thereof
    Shanghai Hengrui Pharmaceutical
    01/10/21
  2520. 72
    Pyridyl benzothiophenes as kinase inhibitors
    Allergan
    01/10/21
  2521. 150
    6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    12/21/20
  2522. 19
    C5-C6-oxacyclic fused iminothiadiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    12/21/20
  2523. 240
    Compounds, compositions and methods
    Denali Therapeutics
    12/21/20
  2524. 11
    Enhancer of zeste homolog 2 inhibitors
    Glaxosmithkline Intellectual Property (No.2
    12/21/20
  2525. 54
    Substituted cyclopropanes as PDE-10 inhibitors
    Sunovion Pharamaceuticals
    12/21/20
  2526. 11
    2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
    Crystalgenomics
    12/20/20
  2527. 12
    2-amino-6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
    H. Lundbeck
    12/20/20
  2528. 20
    3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2, 7-dione compounds for the treatment and prophylaxis of virus infection
    Hoffmann-La Roche
    12/20/20
  2529. 27
    5-aromatic alkynyl substituted benzamide compound and preparation method, pharmaceutical composition, and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    12/20/20
  2530. 43
    6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
    University Of Pittsburgh
    12/20/20
  2531. 65
    Arginase inhibitors as therapeutics
    Mars
    12/20/20
  2532. 17
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    Xw Laboratories
    12/20/20
  2533. 171
    Compounds for the treatment of pain
    Alkermes
    12/20/20
  2534. 3
    Compounds useful for inhibiting ROR-gamma-t
    Eli Lilly
    12/20/20
  2535. 1
    Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
    Suzhou Zelgen Biopharmaceuticals
    12/20/20
  2536. 18
    Diaryl macrocycles as modulators of protein kinases
    Turning Point Therapeutics
    12/20/20
  2537. 262
    Heteroaryl substituted aminopyridine compounds
    Bristol-Myers Squibb
    12/20/20
  2538. 68
    Heterocyclic compounds as immunomodulators
    Incyte
    12/20/20
  2539. 222
    Indole carboxamide compounds
    Bristol-Myers Squibb
    12/20/20
  2540. 37
    Macrocycles as PDE1 inhibitors
    H. Lundbeck
    12/20/20
  2541. 161
    Spiroindolinones as DDR1 inhibitors
    Hoffmann-La Roche
    12/20/20
  2542. 111
    Substituted 5-cyanoindole compounds and uses thereof
    Novartis
    12/20/20
  2543. 249
    Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
    Celgene Car
    12/20/20
  2544. 29
    Tricyclic heterocycles as BET protein inhibitors
    Incyte
    12/20/20
  2545. 35
    Bicyclic proline compounds
    Genentech
    12/14/20
  2546. 8
    Methods to treat lymphoplasmacytic lymphoma
    Dana-Farber Cancer Institute
    12/14/20
  2547. 39
    Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    12/14/20
  2548. 15
    Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    12/14/20
  2549. 259
    2,4-disubstituted pyrimidines useful as kinase inhibitors
    Celgene Car
    12/13/20
  2550. 325
    Aryl ethers and uses thereof
    Peloton Therapeutics
    12/13/20
  2551. 76
    Aza-heteroaryl compounds as PI3K-gamma inhibitors
    Incyte
    12/13/20
  2552. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
    Jenrin Discovery
    12/13/20
  2553. 42
    Compounds for cancer chemotherapeutic sensitization
    Regents Of The University Of Minnesota
    12/13/20
  2554. 191
    Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
    Sanford Burnham Prebys Medical Discovery Institute
    12/13/20
  2555. 5
    Methods and compositions for cell-proliferation-related disorders
    Agios Pharmaceuticals
    12/13/20
  2556. 4
    Pyrrolopyrimidine comprising cyclopentyl substituent
    Centaurus Biopharma
    12/13/20
  2557. 258
    Somatostatin modulators and uses thereof
    Crinetics Pharmaceuticals
    12/13/20
  2558. 594
    Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GluN2B receptor modulators
    Janssen Pharmaceutica
    12/13/20
  2559. 397
    Therapeutic compounds
    Celgene Quanticel Research
    12/13/20
  2560. 26
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The Usa, As Represented By The Secretary, Department Of Health And Human Services
    12/13/20
  2561. 6
    Certain chemical entities, compositions, and methods
    Neupharma
    12/08/20
  2562. 56
    1,3-dihydroxy-phenyl derivatives useful as immunomodulators
    Bristol-Meyers Squibb
    12/07/20
  2563. 18
    1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
    Universitat De Barcelona
    12/07/20
  2564. 212
    Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
    Janssen Pharmaceutica
    12/07/20
  2565. 14
    Cardiac glycoside analogs and their use in methods for inhibition of viral infection
    The John Hopkins University
    12/07/20
  2566. 63
    Chemical compounds
    Astrazeneca
    12/07/20
  2567. 161
    Compounds, compositions, and methods
    Denali Therapautics
    12/07/20
  2568. 26
    Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
    Guangzhou Maxinovel Pharmaceuticals
    12/07/20
  2569. 29
    Cyanopyrrolidine derivatives as inhibitors for DUBs
    Mission Therapeutics
    12/07/20
  2570. 15
    Dopamine D1 receptor positive allosteric modulators
    Eli Lilly
    12/07/20
  2571. 24
    Heterocyclic compounds used as FGFR inhibitors
    Nanjing Innocare Pharma Tech
    12/07/20
  2572. 69
    Imidazopyridazine compounds and their use
    Hutchison Medipharma
    12/07/20
  2573. 97
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics
    12/07/20
  2574. 60
    Method of treatment using substituted imidazo[1,2b]pyridazine compounds
    Array Biopharma
    12/07/20
  2575. 95
    Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
    Loxo Oncology
    12/07/20
  2576. 159
    Selective estrogen receptor down-regulators
    Astrazeneca
    12/07/20
  2577. 7
    TRPV4 antagonists
    Glaxosmithkline Intellectual Property Development
    12/07/20
  2578. 438
    Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions
    Esteve Pharmaceuticals
    12/07/20
  2579. 16
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics
    11/30/20
  2580. 53
    1,4-dicarbonyl-piperidyl derivatives
    Merck Patent
    11/30/20
  2581. 22
    Compounds and compositions as protein kinase inhibitors
    Array Biopharma
    11/30/20
  2582. 149
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences
    11/30/20
  2583. 8
    Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
    Korea Institute Of Science And Technology
    11/30/20
  2584. 40
    Isoquinolones as BTK inhibitors
    Boehringer Ingelheim International
    11/30/20
  2585. 51
    Pharmacokinetically improved compounds
    Surface Logix
    11/30/20
  2586. 42
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics
    11/30/20
  2587. 7
    Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
    Marquette University
    11/30/20
  2588. 114
    Substituted dihydroisoquinolinone compounds
    Pfizer
    11/30/20
  2589. 42
    Substituted imidazo[1,2-a]pyridines as PDE-10 inhibitors
    Sunovion Pharmaceuticals
    11/30/20
  2590. 7
    Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof
    Chia Tai Tianqing Pharmaceutical Group
    11/30/20
  2591. 138
    Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme
    11/30/20
  2592. 13
    Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
    Vtv Therapeutics
    11/30/20
  2593. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    11/29/20
  2594. 22
    4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
    Heptares Therapeutics
    11/29/20
  2595. 61
    A3 adenosine receptor agonists
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    11/29/20
  2596. 58
    Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease
    National Health Research Institutes
    11/29/20
  2597. 356
    Bruton's tyrosine kinase inhibitors
    Sunesis Pharmaceuticals
    11/29/20
  2598. 18
    Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof
    Tianjin Institute Of Pharmaceutical Research
    11/29/20
  2599. 10
    Heteroaryl substituted benzoic acids as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    11/29/20
  2600. 51
    Heterocyclic sulfonamide derivative and medicine containing same
    Ea Pharma
    11/29/20
  2601. 8
    Indane-amines as PD-L1 antagonists
    Chemocentryx
    11/29/20
  2602. 12
    Ingenol analogs, pharmaceutical compositions and methods of use thereof
    Glaxosmithkline Intellectual Property Development
    11/29/20
  2603. 41
    Inhibitors of RET
    Blueprint Medicines
    11/29/20
  2604. 37
    Macrocyclic inhibitors of myeloperoxidase
    Bristol-Myers Squibb
    11/29/20
  2605. 12
    Quinolone-3-diarylethers
    Oregon Health & Science University
    11/29/20
  2606. 12
    SHMT inhibitors
    The Trustees Of Princeton University
    11/29/20
  2607. 211
    Small molecule agonists of neurotensin receptor 1
    Sanford Burnham Prebys Medical Discovery Institute
    11/29/20
  2608. 174
    Substituted 3,6-diazabicyclo[3.2.0]heptanes
    Indivior
    11/29/20
  2609. 1143
    TYK2 inhibitors and uses thereof
    Nimbus Lakshimi
    11/29/20
  2610. 56
    Triazole DAGLα inhibitors
    The Scripps Research Institute
    11/29/20
  2611. 69
    Use of physiological cooling active ingredients, and agents containing such active ingredients
    Symrise
    11/29/20
  2612. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical
    11/22/20
  2613. 22
    Benzimidazoles derivatives as Tec kinases family inhibitors
    Gb005
    11/22/20
  2614. 15
    Cancer therapeutics
    University Of Virginia Patent Foundation
    11/22/20
  2615. 14
    Carboxylic acid compounds
    Sumitomo Dainippon Pharma
    11/22/20
  2616. 63
    Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-HT1A receptors
    Neurolixis
    11/22/20
  2617. 1
    Crystalline FGFR4 inhibitor compound and uses thereof
    Eisai R&D Management
    11/22/20
  2618. 222
    Cycloalkylamines as monoamine reuptake inhibitors
    Sunovion Pharamceuticals
    11/22/20
  2619. 14
    HYPDH inhibitors and methods of use for the treatment of kidney stones
    Wake Forest University Health Sciences
    11/22/20
  2620. 100
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    11/22/20
  2621. 164
    IRAK4 inhibitor and use thereof
    Beijing Hanmi Pharmaceutical
    11/22/20
  2622. 57
    Indazole compounds as FGFR kinase inhibitor, preparation and use thereof
    Shanghai Haihe Pharmaceutical
    11/22/20
  2623. 9
    Nitrogen-containing tricyclic compounds and uses thereof in medicine
    North & South Brother Pharmacy Investment
    11/22/20
  2624. 5
    Organic compounds
    Intra-Cellular Therapies
    11/22/20
  2625. 41
    Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions
    Takeda Pharmaceutical
    11/22/20
  2626. 16
    Prolyl hydroxylase inhibitors
    Aerpio Therapeutics
    11/22/20
  2627. 23
    Pyrrolopyrimidine compound
    Centaurus Biophrama
    11/22/20
  2628. 427
    Quinazolinones as PARP14 inhibitors
    Ribon Therapeutics
    11/22/20
  2629. 27
    SHP2 inhibitors and uses thereof
    Synblia Therapeutics
    11/22/20
  2630. 206
    Substituted quinoxalines as PDE-10 inhibitors
    Sunovion Pharmaceuticals
    11/22/20
  2631. 177
    Triazolones and tetrazolones as inhibitors of ROCK
    Bristol-Myers Squibb
    11/22/20
  2632. 508
    IRAK4 inhibiting agents
    Biogen Ma
    11/21/20
  2633. 11
    2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
    Genentech
    11/20/20
  2634. 27
    5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No.5
    11/20/20
  2635. 153
    Arylamide derivatives having multimodal activity against pain
    Esteve Pharmaceuticals
    11/20/20
  2636. 6
    Bis-pyridazine compounds and their use in treating cancer
    Cancer Research Technology
    11/20/20
  2637. 37
    Cot modulators and methods of use thereof
    Gilead Sciences
    11/20/20
  2638. 33
    Dopamine D3 receptor antagonists having a morpholine moiety
    Indivior
    11/20/20
  2639. 43
    Ether compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    11/20/20
  2640. 58
    Fused tricyclic compounds as Raf kinase inhibitors
    Beigene
    11/20/20
  2641. 159
    Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators
    Novartis
    11/20/20
  2642. 20
    Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
    Boehringer Ingelheim International
    11/20/20
  2643. 24
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D Ip
    11/20/20
  2644. 21
    Kinase inhibitors and their use in cancer therapy
    Technische UniversitÄT Dortmund
    11/20/20
  2645. 28
    Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
    Saint Louis University
    11/20/20
  2646. 87
    Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
    Boehringer Ingelheim International
    11/20/20
  2647. 221
    NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
    Ogeda
    11/20/20
  2648. 5
    Prodrugs of imidazotriazine compounds as CK2 inhibitors
    Bristol-Myers Squibb
    11/20/20
  2649. 803
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics
    11/20/20
  2650. 36
    Sodium channel modulators
    The Florey Institute
    11/20/20
  2651. 107
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International
    11/20/20
  2652. 980
    Substituted piperidine compounds
    Epizyme
    11/20/20
  2653. 3
    Tetrahydroisoquinolines as PRMT5 inhibitors
    Ctxt
    11/20/20
  2654. 9
    Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics
    Galderma Research & Development
    11/13/20
  2655. 122
    Glycosidase inhibitors
    Asceneuron
    11/13/20
  2656. 302
    Isoquinolin-3-YL carboxamides and preparation and use thereof
    Samumed
    11/13/20
  2657. 37
    Piperazinyl methanone NAAA inhibitors
    The Regents Of The University Of California
    11/13/20
  2658. 119
    Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
    Incyte
    11/13/20
  2659. 100
    Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use
    Abbvie
    11/13/20
  2660. 556
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Eli Lilly
    11/13/20
  2661. 71
    TrkA kinase inhibitors, compositions and methods thereof
    Merck Sharp & Dohme
    11/13/20
  2662. 153
    4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators
    Vanderbilt University
    11/09/20
  2663. 3
    4-(biphen-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I) as GABA receptor modulators for use in the treatment of epilepsy and pain
    Pfizer
    11/09/20
  2664. 46
    5H-pyrrolo[2,3-D]pyrimidin-6(7H)-one derivative
    Taiho Pahrmaceutical
    11/09/20
  2665. 208
    Compounds as indoleamine 2,3-dioxygenase inhibitors
    Merck Sharp & Dohme
    11/09/20
  2666. 188
    Methods using HDAC11 inhibitors
    Forma Therapeutics
    11/09/20
  2667. 66
    Pyrimidine FGFR4 inhibitors
    Eisai R&D Management
    11/09/20
  2668. 39
    Quinolone derivatives as FGFR inhibitors
    Principia Biopharma
    11/09/20
  2669. 61
    Substituted amino triazoles useful as human chitinase inhibitors
    Oncoarendi Therapeutics
    11/09/20
  2670. 87
    1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
    St. Jude Children''S Research Hospital
    11/07/20
  2671. 114
    5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis
    Galapagos
    11/07/20
  2672. 34
    Acetyl-CoA carboxylase modulators
    Monsanto Technology
    11/07/20
  2673. 49
    Acyl sulfonamide NaV1.7 inhibitors
    Bristol-Myers Squibb
    11/07/20
  2674. 25
    Benzamide derivative
    Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
    11/07/20
  2675. 62
    Inhibitors of protease-activated receptor-2
    Heptares Therapeutics
    11/07/20
  2676. 130
    Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
    Astex Therapeutics
    11/07/20
  2677. 8
    KSR antagonists
    Icahn School Of Medicine At Mount Sinai
    11/07/20
  2678. 163
    Modulators of sphingosine phosphate receptors
    The Scripps Research Institute
    11/07/20
  2679. 182
    Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
    Forma Therapeutics
    11/07/20
  2680. 119
    Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
    Celgene Quanticel Research
    11/07/20
  2681. 878
    4-azaindole compounds
    Bristol-Myers Squibb
    11/02/20
  2682. 9
    5-HT2CR agonist analogs
    The Board Of Regents Of The University Of Texas System
    11/02/20
  2683. 1
    Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
    Fedora Pharmaceuticals
    11/02/20
  2684. 11
    Compounds and uses thereof
    Kala Pharmaceuticals
    11/02/20
  2685. 76
    Derivatives and methods of treating hepatitis B infections
    Novira Therapeutics
    11/02/20
  2686. 150
    Heteroaryl substituted pyridyl compounds useful as kinase modulators
    Bristol-Myers Squibb
    11/02/20
  2687. 213
    Inhibitors of protein kinases
    Portola Pharmaceuticals
    11/02/20
  2688. 235
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    11/02/20
  2689. 489
    Metallo-beta-lactamase inhibitors
    Merck Sharp & Dohme
    11/02/20
  2690. 117
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme
    11/02/20
  2691. 376
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    11/02/20
  2692. 107
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
    Takeda Pharmaceutical
    11/02/20
  2693. 12
    Tetrahydroisoquinolin-1-one derivative or salt thereof
    Seldar Pharma
    11/02/20
  2694. 38
    3-indol substituted derivatives, pharmaceutical compositions and methods for use
    Pfizer
    11/01/20
  2695. 30
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University
    11/01/20
  2696. 13
    Beta-lactamase inhibitors, formulations, and uses thereof
    University Of South Florida
    11/01/20
  2697. 331
    Biaryl kinase inhibitors
    Bristol-Myers Squibb
    11/01/20
  2698. 96
    Certain chemical entities, compositions, and methods
    Neupharma
    11/01/20
  2699. 141
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
    University Of Washington Through Its Center For
    11/01/20
  2700. 73
    Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
    Ardelyx
    11/01/20
  2701. 4
    Derivatives of sobetirome
    Oregon Health & Science University
    11/01/20
  2702. 75
    Inhibitor of lysine specific demethylase-1
    Celgene Quanticel Research
    11/01/20
  2703. 5
    Macrocycle and composition comprising thereof
    Shenzhen Targetrx
    11/01/20
  2704. 6
    Organic compounds
    Intra-Cellular Therapies
    11/01/20
  2705. 35
    Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
    University Of Pittsburgh
    11/01/20
  2706. 201
    Thiazolidinone compounds and use thereof
    National Health Research Institute
    11/01/20
  2707. 6
    Treatment and diagnosis of melanoma
    The Rockefeller University
    11/01/20
  2708. 118
    Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
    Celgene Quanticel Research
    11/01/20
  2709. 57
    Bicyclic heterocyclic derivatives
    Merck Patent
    10/25/20
  2710. 214
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    Galapagos
    10/25/20
  2711. 98
    Fused heteroaryl derivatives as orexin receptor antagonists
    Merck, Sharp & Dohme
    10/25/20
  2712. 16
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    10/25/20
  2713. 58
    Spirocyclic compounds
    Recurium Ip Holdings
    10/25/20
  2714. 11
    2′-chloro nucleoside analogs for HCV infection
    Idenix Pharmaceuticals
    10/24/20
  2715. 41
    Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
    Incyte
    10/24/20
  2716. 40
    Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity
    Kancera
    10/24/20
  2717. 31
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    10/24/20
  2718. 7
    Flavanone derivatives, and preparation method and use thereof
    Xuanwu Hospital Of Capital Medical University
    10/24/20
  2719. 246
    Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators
    Janssen Pharmaceutica
    10/24/20
  2720. 22
    Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
    Tes Pharma
    10/24/20
  2721. 38
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    10/24/20
  2722. 47
    Oligomer-opioid agonist conjugates
    Inheris Pharmaceuticals
    10/24/20
  2723. 5
    PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
    H. Lundbeck
    10/24/20
  2724. 32
    Piperidine compounds as PCSK9 inhibitors
    Shenzhen Salubris Pharm
    10/24/20
  2725. 11
    Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
    Forma Therapeutics
    10/24/20
  2726. 6
    Sulfamide and sulfamate inhibitors of hHint1
    Regents Of The University Of Minnesota
    10/24/20
  2727. 3
    3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
    Ctxt
    10/19/20
  2728. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D Ip
    10/19/20
  2729. 696
    Heterocyclic compounds and uses thereof
    Plexxikon
    10/19/20
  2730. 165
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences
    10/19/20
  2731. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals
    10/19/20
  2732. 15
    Pyridazinone macrocycles as IRAK inhibitors and uses thereof
    Merck Patent
    10/19/20
  2733. 89
    Pyrrolopyrimidine derivatives as TAM inhibitors
    Incyte
    10/19/20
  2734. 106
    Serine/threonine kinase inhibitors
    Genentech
    10/19/20
  2735. 107
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors
    Incyte Holdings
    10/19/20
  2736. 190
    1 H-pyrazolo[4,3-B]pyridines as PDE1 inhibitors
    H. Lundbeck
    10/18/20
  2737. 1156
    TYK2 inhibitors and uses thereof
    Nimbus Lakshimi
    10/18/20
  2738. 73
    Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb
    10/18/20
  2739. 514
    6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1H)-one as APJ agonists
    Bristol-Myers Squibb
    10/12/20
  2740. 16
    Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
    Neomed Institute
    10/12/20
  2741. 51
    Benzimidazole-linked indole compound acting as novel divalent IAP antagonist
    Medshine Discovery
    10/12/20
  2742. 303
    Bicyclic compound and use thereof for inhibiting SUV39H2
    Oncotherapy Science
    10/12/20
  2743. 36
    Compounds and methods of use
    Medivation Technologies
    10/12/20
  2744. 30
    Covalent small molecule DCN1 inhibitors and therapeutic methods using the same
    The Regents Of The University Of Michigan
    10/12/20
  2745. 12
    Fused heterocyclic ring compounds and method of treating retinal disease using same
    The Industry & Academic Cooperation In Chungnam National University (Iac
    10/12/20
  2746. 66
    Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
    Beigene
    10/12/20
  2747. 26
    Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
    Boehringer Ingelheim International
    10/12/20
  2748. 117
    Indazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    10/12/20
  2749. 13
    Inhibitors of cellular necrosis and related methods
    President And Fellows Of Harvard College
    10/12/20
  2750. 303
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    10/12/20
  2751. 37
    Lactam compound derivative and application thereof
    Nhwa Pharma.
    10/12/20
  2752. 20
    Morpholine derivative
    Hoffmann-La Roche
    10/12/20
  2753. 15
    Selective NR2B antagonists
    Bristol-Myers Squibb
    10/12/20
  2754. 283
    Substituted benzamides
    Hoffmann-La Roche
    10/12/20
  2755. 37
    Substituted bicyclic fused ring compounds as indoleamine-2,3-dioxygenase inhibitors
    Iomet Pharma
    10/12/20
  2756. 68
    Substituted nitrogen containing compounds
    Bristol-Myers Squibb
    10/12/20
  2757. 5
    Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
    Northwestern University
    10/12/20
  2758. 121
    Tricyclic compounds as inhibitors of mutant IDH enzymes
    Merck Sharp & Dohme
    10/12/20
  2759. 33
    WDR5 inhibitors and modulators
    Vanderbilt University
    10/12/20
  2760. 14
    Compounds for the treatment of addiction
    Amygdala Neurosciences
    10/02/20
  2761. 193
    Methods using HDAC11 inhibitors
    Forma Therapeutics
    10/02/20
  2762. 31
    Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity
    Shionogi
    10/02/20
  2763. 218
    PARG inhibitory compounds
    Cancer Research Technology
    10/02/20
  2764. 11
    Quinazoline derivatives substituted by aniline, preparation method and use thereof
    Xuanzhu Pharma
    10/02/20
  2765. 13
    Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
    Forma Therapeutics
    10/02/20
  2766. 59
    Spirocyclic compounds
    Recurium Ip Holdings
    10/02/20
  2767. 256
    Substituted piperidine compound and use thereof
    Takeda Pharmaceutical
    10/02/20
  2768. 118
    Tetrahydroisoquinoline derived PRMT5-inhibitors
    Ctxt
    10/02/20
  2769. 404
    Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines and substituted imidazo[1,2-b]pyridazines as PI3K-gamma inhibitors
    Incyte
    09/26/20
  2770. 29
    Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Incyte
    09/25/20
  2771. 31
    Broad-spectrum non-covalent coronavirus protease inhibitors
    Purdue Research Foundation
    09/25/20
  2772. 155
    Compounds that inhibit MPS1 kinase
    Cancer Research Technology
    09/25/20
  2773. 66
    Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International
    09/25/20
  2774. 7
    Enhancer of Zeste Homolog 2 inhibitors
    Glaxosmithkline
    09/25/20
  2775. 32
    Six-membered ring benzo derivatives as DPP-4 inhibitor and use thereof
    East China University Of Science And Technology
    09/25/20
  2776. 576
    Substituted pyrazin-2-amines as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    09/25/20
  2777. 955
    [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
    Bristol-Myers Squibb
    09/24/20
  2778. 6
    Aminopyridinecarboxamides as CXCR2 modulators
    Syntrix Biosystems
    09/20/20
  2779. 12
    IBAT inhibitors for the treatment of liver diseases
    Albireo
    09/20/20
  2780. 77
    Macrocycles as factor XIa inhibitors
    Bristol-Myers Squibb
    09/20/20
  2781. 202
    Mixed lineage kinase inhibitors for HIV/AIDS therapies
    The University Of Rochester
    09/20/20
  2782. 25
    Positive allosteric modulators of the GLP-1 receptor
    Vanderbilt University
    09/20/20
  2783. 124
    Pyrazolopyridinamines as MKNK1 and MKNK2 inhibitors
    Bayer Pharma Aktiengesellschaft
    09/20/20
  2784. 42
    Pyrimidine compounds as JAK kinase inhibitors
    Theravance Biopharma R&D Ip
    09/20/20
  2785. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica
    09/20/20
  2786. 37
    Substituted indazole derivatives active as kinase inhibitiors
    Nerviano Medical Sciences
    09/20/20
  2787. 13
    Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb
    09/20/20
  2788. 389
    1,3-thiazol-2-yl substituted benzamides
    Bayer Aktiengesellschaft
    09/14/20
  2789. 86
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    09/14/20
  2790. 9
    2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
    Algiax Pharmaceuticals
    09/14/20
  2791. 80
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences
    09/14/20
  2792. 7
    Factor XIa inhibitors
    Merck Sharp & Dohme
    09/14/20
  2793. 5
    Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
    Incyte Incorporation
    09/14/20
  2794. 277
    Tricyclic heterocycles as BET protein inhibitors
    Incyte Holdings
    09/09/20
  2795. 76
    1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
    Chong Kun Dang Pharmaceutical
    09/08/20
  2796. 49
    2,4-disubstituted pyrimidines as CDK inhibitors
    Shanghai Xunhe Pharmaceutical Technology
    09/08/20
  2797. 3
    Amino pyrimidine SSAO inhibitors
    Eli Lilly
    09/08/20
  2798. 113
    Aminopyrimidinyl compounds
    Pfizer
    09/08/20
  2799. 234
    Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
    Enanta Pharmaceuticals
    09/08/20
  2800. 29
    Compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
    Industry Academic Cooperation Foundation Keimyung University
    09/08/20
  2801. 10
    Multi-tyrosine kinase inhibitors derivatives and methods of use
    Ontogenesis
    09/08/20
  2802. 11
    Process of making somatostatin modulators
    Crinetics Pharmaceuticals
    09/08/20
  2803. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical
    09/08/20
  2804. 184
    Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same
    Je Il Pharmaceutical
    09/08/20
  2805. 120
    Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (RORγ(T))
    Galderma Research & Development
    09/07/20
  2806. 10
    Substituted pyrrolo[2,3-b]pyridines as inhibitors of cellular necroptosis
    Institut National De La Sante Et De La Recherche Medicale (Inserm
    09/07/20
  2807. 11
    Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
    Bristol_Myers Squibb
    09/07/20
  2808. 7
    [1,2,3]triazolo[4,5-D]pyrimidine derivatives
    Hoffmann-La Roche
    09/07/20
  2809. 38
    [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
    Hoffmann-La Roche
    09/07/20
  2810. 15
    [1,2,3]triazolo[4,5-d]pyrimidine derivatives
    Hoffmann-La Roche
    09/07/20
  2811. 190
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    08/31/20
  2812. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Holdings
    08/31/20
  2813. 6
    PET Imaging agents
    Novartis
    08/31/20
  2814. 328
    Sulfonyl amide derivatives for the treatment of abnormal cell growth
    Pfizer
    08/31/20
  2815. 7
    [1,2,3]triazolo[4,5-D]pyrimidine derivatives
    Hoffmann-La Roche
    08/31/20
  2816. 168
    Heterocyclic compounds useful as Pim kinase inhibitors
    Incyte
    08/30/20
  2817. 128
    γ-diketones as Wnt/β-catenin signaling pathway activators
    Samumed
    08/24/20
  2818. 55
    1,3,4-thiadiazole compounds and their use in treating cancer
    Astrazeneca
    08/24/20
  2819. 21
    1-sulfonamido-4-aryloxy compounds, and preparation method and medicinal application thereof
    China Pharmaceutical University
    08/24/20
  2820. 40
    Amino pyrimidine derivatives
    Novartis
    08/24/20
  2821. 118
    Aminopyridazinone compounds as protein kinase inhibitors
    Jiangsu Hengrui Medicine
    08/24/20
  2822. 19
    Azepine derivatives as 5-HT7 receptor modulators
    Korea Institute Of Science And Technology
    08/24/20
  2823. 15
    BCL-2 inhibitors
    Newave Pharmaceutical
    08/24/20
  2824. 182
    Benzimidazol-2-amines as mIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    08/24/20
  2825. 912
    Benzolactam compounds as protein kinase inhibitors
    Otsuka Pharmaceutical
    08/24/20
  2826. 115
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases
    University Of Washington
    08/24/20
  2827. 348
    Heterocyclylamines as PI3K inhibitors
    Incyte Holdings
    08/24/20
  2828. 86
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    08/24/20
  2829. 298
    Human plasma kallikrein inhibitors
    Biocryst Pharmaceuticals
    08/24/20
  2830. 137
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent
    08/24/20
  2831. 21
    Inhibitors of the IRE-1/XBP-1 pathway and methods of using thereof
    H. Lee Moffitt Cancer Center And Research Institute
    08/24/20
  2832. 2
    Methods for treating pulmonary hypertension
    Reviva Pharmaceuticals
    08/24/20
  2833. 60
    Negative allosteric modulators of metabotropic glutamate receptor 3
    Vanderbilt University
    08/24/20
  2834. 31
    Pharmaceutical composition comprising pyridone derivatives
    Sk Biopharmaceuticals
    08/24/20
  2835. 539
    Purinones as ubiquitin-specific protease 1 inhibitors
    Forma Therapeutics
    08/24/20
  2836. 124
    Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors
    Novartis
    08/24/20
  2837. 80
    Pyrazolo[3,4-d]pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    08/24/20
  2838. 145
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte
    08/24/20
  2839. 104
    Substituted indoles as modulators of ROR-gamma
    Vitae Pharmaceuticals
    08/24/20
  2840. 815
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    08/24/20
  2841. 18
    Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors
    The Board Of Trustees Of The University Of Illinois
    08/24/20
  2842. 239
    Therapeutic compounds and methods of use thereof
    Genentech
    08/24/20
  2843. 509
    Tricyclic compounds as inhibitors of mutant IDH enzymes
    Merck Sharp & Dohme
    08/24/20
  2844. 273
    Tricyclic heterocycles as bet protein inhibitors
    Incyte
    08/24/20
  2845. 154
    Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors
    Proximagen
    08/19/20
  2846. 155
    Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors
    Proximagen
    08/19/20
  2847. 480
    3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
    Bayer Pharma Aktiengesellschaft
    08/17/20
  2848. 46
    4H-pyrrolo[3,2-C]pyridin-4-one derivatives
    Bayer Pharma Aktiengesellschaft
    08/17/20
  2849. 5
    6,7-cyclicmorphinan derivatives and use thereof
    Purdue Pharma
    08/17/20
  2850. 93
    Difluoroketamide derivatives
    Hoffmann-La Roche
    08/17/20
  2851. 62
    Fused amino pyridine as HSP90 inhibitors
    Curis
    08/17/20
  2852. 15
    HDAC inhibitors
    Biomarin Pharmaceutical
    08/17/20
  2853. 6
    Heterocyclylmethyl-thienouracile as antagonists of the adenosine-A2B-receptor
    Bayer Pharma Aktiengesellschaft
    08/17/20
  2854. 104
    Methyl- and trifluromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
    Pfizer
    08/17/20
  2855. 52
    Piperidinyl derivatives
    Merck Patent
    08/17/20
  2856. 82
    Pyrimidinones as PI3K inhibitors
    Incyte
    08/17/20
  2857. 69
    Pyrrole heteroaryl ring derivative and method of use thereof
    Jiangsu Hengrui Medicine
    08/17/20
  2858. 231
    Soluble guanylate cyclase stimulators
    Merck Sharp & Dohme
    08/17/20
  2859. 117
    Substituted nucleoside derivatives useful as anticancer agents
    Pfizer
    08/17/20
  2860. 27
    Substituted spirocycles
    Boehringer Ingelheim International
    08/17/20
  2861. 43
    Substituted tetrahydrocarbazole and carbazole carboxamide compounds
    Bristol-Myers Squibb
    08/17/20
  2862. 169
    Triaza-spirodecanones as DDR1 inhibitors
    Hoffmann-La Roche
    08/17/20
  2863. 214
    Tricyclic PI3K inhibitor compounds and methods of use
    Genentech
    08/17/20
  2864. 57
    2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom
    Shanghai Haiyan Pharmaceutical Technology
    08/16/20
  2865. 47
    2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
    Bayer Pharma Aktiegesellschaft
    08/16/20
  2866. 13
    Bipyrazole derivatives as JAK inhibitors
    Incyte
    08/16/20
  2867. 47
    Heterocyclic compounds and uses thereof
    Celgene Car
    08/16/20
  2868. 13
    Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments
    The Regents Of The University Of California
    08/16/20
  2869. 10
    Kinase inhibitors
    Topivert Pharma
    08/16/20
  2870. 14
    Non-aromatic difluoro analogues of resorcylic acid lactones
    University Of North Carolina At Greensboro
    08/16/20
  2871. 33
    Oxazole orexin receptor antagonists
    Merck Sharp & Dohme
    08/16/20
  2872. 235
    Pyrazolopyridine compounds and uses thereof
    Incyte
    08/16/20
  2873. 268
    Tricyclic sulfones as ROR gamma modulators
    Bristol-Myers Squibb
    08/16/20
  2874. 179
    Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
    Allergan
    08/16/20
  2875. 9
    [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof
    Santen Pharmaceutical
    08/16/20
  2876. 74
    Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
    Rodin Therapeutics
    08/12/20
  2877. 20
    Pyrrolo[2,3-d]pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    08/12/20
  2878. 22
    Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    08/12/20
  2879. 7
    Quinoxaline derivatives useful as FGFR kinase modulators
    Astex Therapeutics
    08/12/20
  2880. 47
    Substituted morpholine derivatives having activity against pain
    Esteve Pharmaceuticals
    08/12/20
  2881. 252
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    08/12/20
  2882. 9
    Sulfur-containing compounds targeting vesicular acetylcholine transporter
    Washington University
    08/12/20
  2883. 3
    Tetrahydroisoquinolines as PRMT5 inhibitors
    Ctxt
    08/12/20
  2884. 99
    Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    08/12/20
  2885. 27
    5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    08/02/20
  2886. 295
    Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
    Merck Patent
    08/02/20
  2887. 111
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    08/02/20
  2888. 23
    Gelatinase inhibitors and use thereof
    Iproteos
    08/02/20
  2889. 97
    Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
    Janssen Pharmaceutica
    08/02/20
  2890. 136
    Isoxazole compounds as inhibitors of heat shock proteins
    The Institute Of Cancer Research
    08/02/20
  2891. 16
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    08/02/20
  2892. 48
    Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
    Bayer Pharma Aktiengesellschaft
    08/02/20
  2893. 41
    (Hetero)aryl imidazoles/pyrazoles for treatment of neurological disorders
    Hoffmann-La Roche
    07/27/20
  2894. 417
    6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD
    Takeda Pharmaceutical
    07/27/20
  2895. 13
    Amino-triazolopyridine compounds and their use in treating cancer
    Astrazeneca
    07/27/20
  2896. 9
    Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient
    Industry-Academic Cooperation Foundation Gyeongsang National University
    07/27/20
  2897. 7
    Compositions and methods for treating neoplasia, inflammatory disease and other disorders
    Dana-Farber Cancer Institute
    07/27/20
  2898. 27
    Compounds I
    Benevolentai Cambridge
    07/27/20
  2899. 34
    Compounds and compositions as toll-like receptor 7 agonists
    Novartis
    07/27/20
  2900. 23
    Compounds as inhibitors of DNA methyltransferases
    FundaciÓN Para La InvestigaciÓN MÉDica Aplicada
    07/27/20
  2901. 139
    Compounds for inflammation and immune-related uses
    Prcl Research
    07/27/20
  2902. 153
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    07/27/20
  2903. 27
    Dimeric compounds
    Hoffmann-La Roche
    07/27/20
  2904. 15
    Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
    Boehringer Ingelheim International
    07/27/20
  2905. 7
    Heteroaryldiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals
    07/27/20
  2906. 23
    Janus kinase inhibitors and uses thereof
    Purdue Research Foundation
    07/27/20
  2907. 64
    Kv1.3 inhibitors and their medical applications
    4Sc
    07/27/20
  2908. 57
    N2-phenyl-pyrido[3,4-D]pyrimidine-2, 8-diamine derivatives and their use as Mps1 inhibitors
    Cancer Research Technology
    07/27/20
  2909. 21
    PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Mitobridge
    07/27/20
  2910. 96
    Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
    Loxo Oncology
    07/27/20
  2911. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees Of Columbia University In The City Of New York
    07/27/20
  2912. 49
    TGF beta receptor antagonists
    Bristol-Myer Squibb
    07/27/20
  2913. 40
    Tetrahydronaphthalene estrogen receptor modulators and uses thereof
    Genentech
    07/27/20
  2914. 68
    Tetrahydronaphthyl urea derivative
    Mochida Pharmaceutical
    07/27/20
  2915. 2
    Tetrahydropyridopyrazine modulators of GPR6
    Takeda Pharmaceutical
    07/27/20
  2916. 23
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals
    07/27/20
  2917. 9
    Triazolopyridine inhibitors of myeloperoxidase
    Bristol-Myers Squibb
    07/27/20
  2918. 66
    Tricyclic compounds as inhibitors of mutant IDH enzymes
    Merck Sharp & Dohme
    07/27/20
  2919. 547
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    07/20/20
  2920. 11
    Heterocyclic compounds as kinase inhibitors
    Translational Drug Development
    07/20/20
  2921. 119
    Heterocyclic inhibitors of ATR kinase
    Board Of Regents, The University Of Texas System
    07/20/20
  2922. 72
    Kinase inhibitors
    Topivert Pharma
    07/20/20
  2923. 25
    Macrocyclic immunomodulators
    Chemocentryx
    07/20/20
  2924. 330
    PRMT5 inhibitors and uses therof
    Epizyme
    07/20/20
  2925. 103
    Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
    Tolero Pharmaceuticals
    07/20/20
  2926. 323
    3-amino-pyridines as GPBAR1 agonists
    Hoffmann-La Roche
    07/13/20
  2927. 19
    Azetidine derivatives
    Vernalis (R&D
    07/13/20
  2928. 237
    Carbazole-containing sulfonamides as cryptochrome modulators
    Synchronicity
    07/13/20
  2929. 35
    Compounds as diacylglycerol acyltransferase inhibitors
    Glaxosmithkline
    07/13/20
  2930. 23
    Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases
    Orca Pharmaceuticals
    07/13/20
  2931. 63
    Macrocyclic LRRK2 kinase inhibitors
    Oncodesign
    07/13/20
  2932. 23
    Morphinan derivative and medical usage thereof
    University Of Tsukuba
    07/13/20
  2933. 56
    Substituted piperazines as selective HDAC1,2 inhibitors
    Regenacy Pharmaceuticals
    07/13/20
  2934. 35
    Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof
    Pfizer
    07/13/20
  2935. 91
    Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
    Lycera
    07/13/20
  2936. 25
    Treatment of inflammatory disorders in non-human mammals
    The Regents Of The University Of California
    07/13/20
  2937. 7
    Tricyclic compound and JAK inhibitor
    Nissan Chemical
    07/13/20
  2938. 419
    Tricyclic compounds and compositions as kinase inhibitors
    Novartis
    07/13/20
  2939. 490
    AMPK-activating heterocyclic compounds and methods for using the same
    Rigel Pharmaceuticals
    07/06/20
  2940. 58
    Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
    Axovant Sciences
    07/06/20
  2941. 9
    Aryl acylsulfonamides as BLT1 antagonists
    Merck Sharp & Dohme
    07/06/20
  2942. 25
    Benzazepine dicarboxamide compounds with tertiary amide function
    Hoffmann-La Roche
    07/06/20
  2943. 5
    Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP)
    Bsim Therapeutics
    07/06/20
  2944. 25
    Compounds and compositions useful for treating disorders related to NTRK
    Blueprint Medicines
    07/06/20
  2945. 7
    Cyclobutyl-imidazolidinone compounds
    Eli Lilly
    07/06/20
  2946. 104
    Farnesoid X receptor agonists and uses thereof
    Metacrine
    07/06/20
  2947. 82
    Heterocyclic compounds and methods of their use
    Novartis
    07/06/20
  2948. 28
    Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors
    Elanco Tiergesundheit
    07/06/20
  2949. 20
    Indolin-2-one derivatives
    Hoffmann-La Roche
    07/06/20
  2950. 47
    N-Methylbenzimidazoles as mIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    07/06/20
  2951. 5
    Oxy-cyanoquinolinone PDE9 inhibitors
    Merck, Sharp & Dohme
    07/06/20
  2952. 5
    Phenyl-cyanoquinolinone PDE9 inhibitors
    Merck Sharp & Dohme
    07/06/20
  2953. 55
    Potent soluble epdxide hydrolase inhibitors
    Eicosis
    07/06/20
  2954. 142
    Pyrrolopyrimidine compounds and uses thereof
    Hutchison Medipharma
    07/06/20
  2955. 40
    Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
    The Board Of Regents Of The University Of Texas System
    07/06/20
  2956. 628
    Substituted 4-azaindoles and their use as GluN2B receptor modulators
    Janssen Pharmaceutica
    07/06/20
  2957. 17
    Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
    Pfizer
    07/06/20
  2958. 163
    Sulfonamide compounds and uses as TNAP inhibitors
    Sanford-Burnham Prebys Medical Discovery Institute
    07/06/20
  2959. 96
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte Holdings
    07/06/20
  2960. 20
    Alkylated imino sugars exhibiting glucosidase inhibition and their method of use
    TBA
    06/29/20
  2961. 41
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingleheim International
    06/29/20
  2962. 1
    Modulation of N-acylethanolamine-hydrolysing acid amidase (NAAA) for disease treatment
    Fondazione Istituto Italiano Di Tecnologia
    06/29/20
  2963. 92
    N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    Kalvista Pharmaceuticals
    06/29/20
  2964. 2
    Pyridinecarboxamide derivatives, preparation method thereof and pharmaceutical uses thereof
    Jiangsu Hengrui Medicine
    06/29/20
  2965. 6
    Substituted quinolinones as PDE9 inhibitors
    Merck Sharp & Dohme
    06/29/20
  2966. 300
    Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6H)-ones
    Dart Neuroscience (Cayman
    06/29/20
  2967. 95
    4-cyano-benzyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
    Boehringer Ingelheim International
    06/21/20
  2968. 250
    4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
    Bristol-Myers Squibb
    06/21/20
  2969. 10
    Acceleration of diabetic wound healing
    University Of Notre Dame Du Lac
    06/21/20
  2970. 46
    Aryl acylsulfonamides as BLT1 antagonists
    Merk Sharp & Dohme
    06/21/20
  2971. 16
    Bruton's tyrosine kinase inhibitors
    Zibo Biopolar Changsheng Pharmaceutical
    06/21/20
  2972. 19
    D-amino acid oxidase inhibitors and therapeutic uses thereof
    Syneurx International (Taiwan
    06/21/20
  2973. 23
    Fused pyrazole derivatives, preparation method thereof, and use thereof in treatment of cancers, inflammation and immune diseases
    Beijing Innocare Pharma Tech
    06/21/20
  2974. 174
    Glycosidase inhibitors
    Asceneuron
    06/21/20
  2975. 13
    Heterocycles useful as IDO and TDO inhibitors
    Hangzhou Innogate Pharma
    06/21/20
  2976. 79
    Histone demethylase inhibitors
    Celgene Quanticel Research
    06/21/20
  2977. 3
    Inhibitors of ACK1/TNK2 tyrosine kinase
    H. Lee Moffitt Cancer Center And Research Institute
    06/21/20
  2978. 201
    Kinase inhibitors and method of treating cancer
    University Health Network
    06/21/20
  2979. 201
    Metalloenzyme inhibitor compounds
    Selenity Therapeutics (Bermuda
    06/21/20
  2980. 64
    N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
    Novartis
    06/21/20
  2981. 8
    Pyrimidinones as factor XIa inhibitors
    Bristol-Myers Squibb
    06/21/20
  2982. 935
    Pyrrolo[1,2-b]pyridazine derivatives
    Gilead Sciences
    06/21/20
  2983. 26
    Salts and processes of preparing a PI3K inhibitor
    Incyte
    06/21/20
  2984. 14
    Substituted 1H-indole-2-carboxamide compounds as indoleamine-2,3-dioxygenase inhibitors
    Merck Sharp & Dohme
    06/21/20
  2985. 286
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    06/21/20
  2986. 18
    Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
    Ono Pharmaceutical
    06/21/20
  2987. 341
    TGFβ receptor antagonist
    Bristol-Myers Squibb
    06/21/20
  2988. 11
    TYK2 inhibitors, uses, and methods for production thereof
    Nimbus Lakshmi
    06/21/20
  2989. 25
    Treatment of neurodegenerative diseases through inhibition of HSP90
    Sloan-Kettering Institute For Cancer Research
    06/21/20
  2990. 66
    Triazolyl pyrimidinone compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    06/21/20
  2991. 5
    Xanthine derivative
    Jiangsu Tasly Diyi Pharmaceutical
    06/21/20
  2992. 11
    2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1
    International Society For Drug Development
    06/12/20
  2993. 233
    Biaryl kinase inhibitors
    Bristol-Myers Squibb
    06/12/20
  2994. 158
    Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
    Array Biopharma
    06/12/20
  2995. 10
    Compounds and uses thereof
    Kala Pharmaceuticals
    06/12/20
  2996. 212
    Factor IXa inhibitors
    Merck Sharp & Dohme
    06/12/20
  2997. 263
    Somatostatin modulators and uses thereof
    Crinetics Pharmaceuticals
    06/12/20
  2998. 268
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Missions Therapeutics
    06/09/20
  2999. 267
    Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    06/09/20
  3000. 35
    Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    06/09/20
  3001. 595
    GLS1 inhibitors for treating disease
    The University Of Texas System
    06/08/20
  3002. 1
    Inhibitor of the mutated isocitrate dehydrogenase IDH1 R132H
    Bayer Pharma Aktiengesellschaft
    06/08/20
  3003. 13
    Pyrazolopyrimidone or Pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof
    Shanghai Hengrui Pharmaceutical
    06/08/20
  3004. 7
    Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
    Gilead Sciences
    06/08/20
  3005. 15
    1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
    Astrazeneca
    06/01/20
  3006. 38
    4-piperidinyl compounds for use as tankyrase inhibitors
    Novartis
    06/01/20
  3007. 67
    BMP inhibitors and methods of use thereof
    The Brigham And Women'S Hospital
    06/01/20
  3008. 42
    Benzimidazole derivatives as bromodomain inhibitors
    Gilead Sciences
    06/01/20
  3009. 18
    Benzoxazinone amides as mineralocorticoid receptor modulators
    Astrazeneca
    06/01/20
  3010. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    06/01/20
  3011. 11
    Fused imidazole compounds
    Ono Pharmaceutical
    06/01/20
  3012. 68
    Piperidine isoxazole and isothiazole orexin receptor antagonists
    Merck Sharp & Dohme
    06/01/20
  3013. 14
    Substituted pyridazines for the treatment of pain
    Inhibitaxin
    06/01/20
  3014. 276
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Ogeda
    06/01/20
  3015. 12
    Benzimidazole derivatives, preparation method therefor, and applications thereof
    TBA
    05/31/20
  3016. 35
    Biaryltriazole inhibitors of macrophage migration inhibitory factor
    Yale University
    05/31/20
  3017. 361
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer
    05/31/20
  3018. 27
    C5-C6-carbocyclic fused iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
    TBA
    05/31/20
  3019. 59
    Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2—negative allosteric modulators, compositions, and their use
    TBA
    05/31/20
  3020. 41
    Cyclic compounds useful as modulators of TNF α
    Bristol-Myers Squibb
    05/31/20
  3021. 11
    FXR (NR1H4) modulating compounds
    Gilead Sciences
    05/31/20
  3022. 107
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    05/31/20
  3023. 70
    Heterocyclic compounds as inhibitors of platelet aggregation
    Universite De Montreal
    05/31/20
  3024. 52
    Heterocyclic inhibitors of monocarboxylate transporter
    The Scripps Research Institute
    05/31/20
  3025. 510
    Inhibitors of beta-secretase
    Vitae Pharmaceuticals
    05/31/20
  3026. 86
    Inhibitors of hepatitis C virus
    Gilead Pharmasset
    05/31/20
  3027. 61
    Neuroactive steroids, compositions, and uses thereof
    Sage Therapeutics
    05/31/20
  3028. 94
    Non-aromatic heterocyclic derivative having MGAT2 inhibitory activity
    Shionogi
    05/31/20
  3029. 53
    Phenyl-(aza)cycloalkyl carboxylic acid GPR120 modulators
    Bristol=Myers Squibb
    05/31/20
  3030. 280
    Pyrazolopyrimidine inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    05/31/20
  3031. 162
    Pyrrolotriazine inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    05/31/20
  3032. 123
    Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
    Beijing Tide Pharmaceutical
    05/31/20
  3033. 23
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders
    Takeda Pharmaceutical
    05/31/20
  3034. 9
    Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases
    Hanmi Pharm.
    05/31/20
  3035. 149
    1,2-substituted cyclopentanes as orexin receptor antagonists
    Takeda Pharmaceutical
    05/26/20
  3036. 9
    C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
    Youngene Therapeutics
    05/26/20
  3037. 99
    Compounds and compositions as inhibitors of MEK
    Novartis
    05/26/20
  3038. 21
    Cyclohexyl pyridine derivative
    Kissei Pharmaceutical
    05/26/20
  3039. 120
    Ethyldiamine orexin receptor antagonists
    Merck Sharp & Dohme
    05/26/20
  3040. 111
    Ethynyl derivatives
    Hoffman-La Roche
    05/26/20
  3041. 13
    Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
    Allergan
    05/26/20
  3042. 4
    Histone deacetylase inhibitors and methods for use thereof
    Reaction Biology
    05/26/20
  3043. 60
    Method of treatment using substituted imidazo[1,2b]pyridazine compounds
    Array Biopharma
    05/26/20
  3044. 147
    Pharmaceutical compounds
    Cascadian Therapeutics
    05/26/20
  3045. 3
    Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound
    Shenzhen Chipscreen Biosciences
    05/26/20
  3046. 108
    Pyrazole, triazole and tetrazole orexin receptor antagonists
    Merck Sharp & Dohme
    05/26/20
  3047. 78
    2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors
    4Sc
    05/18/20
  3048. 135
    Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors
    Ctxt
    05/18/20
  3049. 24
    Bicyclic fused pyrimidine compounds as TAM inhibitors
    Incyte
    05/18/20
  3050. 135
    Carboxamide derivatives and use thereof
    Purdue Pharma
    05/18/20
  3051. 48
    Combination treatment comprising administration of 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines
    H. Lundbeck
    05/18/20
  3052. 40
    Inhibitors of RPN11
    California Institute Of Technology
    05/18/20
  3053. 105
    Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
    Array Biopharma
    05/18/20
  3054. 80
    Pyridine derivatives
    Astellas Pharma
    05/18/20
  3055. 76
    Pyrrolidinone derivatives as MetAP-2 inhibitors
    Merck Patent
    05/18/20
  3056. 213
    Quinazolinone and isoquinolinone derivative
    Chugai Seiyaku Kabushiki Kaisha
    05/18/20
  3057. 200
    Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
    Beigene
    05/18/20
  3058. 40
    Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
    University Of North Carolina At Chapel Hill
    05/18/20
  3059. 43
    (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
    Oryzon Genomics
    05/11/20
  3060. 64
    6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
    Pfizer
    05/11/20
  3061. 34
    Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof
    Enanta Pharmaceuticals
    05/11/20
  3062. 27
    Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
    Dana-Farber Cancer Institute
    05/11/20
  3063. 8
    Combination Alzheimer therapy using anti-N3pGlu Abeta antibodies + a BACE inhibitor
    Eli Lilly
    05/11/20
  3064. 142
    Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
    Incyte
    05/11/20
  3065. 13
    Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
    Effector Therapeutics
    05/11/20
  3066. 111
    P2X7 Modulators
    Janssen Pharmaceutica
    05/11/20
  3067. 387
    Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
    Incyte Holdings
    05/11/20
  3068. 24
    Prolyl hydroxylase inhibitors and methods of use
    Akebia Therapeutics
    05/11/20
  3069. 21
    Pyrazines as modulators of GPR6
    Takeda Pharmaceutical
    05/11/20
  3070. 143
    Pyrazole compounds and methods of making and using same
    Abide Therapeutics
    05/11/20
  3071. 150
    Pyridone derivative, pharmaceutical containing the same and methods of use thereof
    Kaken Pharmaceutical
    05/11/20
  3072. 61
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as BRD4 inhibitors
    Boehringer Ingelheim International
    05/11/20
  3073. 69
    Substituted pyrrolidines as mGluR5 antagonists
    Hua Medicine (Shanghai
    05/11/20
  3074. 135
    Substituted pyrrolizine compounds and uses thereof
    Gilead Sciences
    05/11/20
  3075. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    05/11/20
  3076. 22
    Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb
    05/11/20
  3077. 118
    Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
    Celgene
    05/11/20
  3078. 14
    Triazine carboxamides as sodium channel blockers
    Purdue Pharma
    05/11/20
  3079. 3
    Urea derivatives and uses thereof
    Kala Pharmaceuticals
    05/11/20
  3080. 21
    Compounds and methods for inhibiting Cif virulence factor
    Dartmouth College
    05/10/20
  3081. 24
    Imidazol- or 1,2,4-triazol-derivatives and their use
    Universite De Lille 2 Droit Et Sante
    05/10/20
  3082. 196
    Indole derivatives and their use in neurodegenerative diseases
    Merck Patent
    05/10/20
  3083. 61
    Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure
    Universitetet I Oslo
    05/10/20
  3084. 46
    N-benzoate group substituted benzopyrroline-2-one derivative and use thereof
    Beijing Hanmi Pharmaceutical
    05/10/20
  3085. 13
    Preparation and use of 7a-heterocycle substituted-6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
    TBA
    05/10/20
  3086. 6
    Pyrazolylaminobenzimidazole derivatives as JAK inhibitors
    Eli Lilly
    05/10/20
  3087. 638
    Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors
    Array Biopharma
    05/10/20
  3088. 227
    Quinazoline and quinoline compounds and uses thereof
    Millennium Pharmaceuticals
    05/10/20
  3089. 19
    Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
    Beijing Tide Pharmaceutical
    05/10/20
  3090. 365
    Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders
    The Scripps Research Institute
    05/10/20
  3091. 13
    Substituted piperidinyl tetrahydroquinolines
    Bayer Pharma Aktiengesellschaft
    05/10/20
  3092. 114
    Triazoles as NR2B receptor inhibitors
    Janssen Pharmaceuticals
    05/10/20
  3093. 11
    10-substituted morphinan hydantoins
    Purdue Pharma
    05/07/20
  3094. 32
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
    Respivert
    05/05/20
  3095. 10
    2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
    Georgetown University
    05/05/20
  3096. 138
    Compositions useful for treating disorders related to kit
    Blueprint Medicines
    05/05/20
  3097. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    05/05/20
  3098. 16
    H3 antagonists containing phenoxypiperidine core structure
    Richter Gedeon
    05/05/20
  3099. 149
    Heteroarylamide inhibitors of TBK1
    Takeda Pharmaceutical
    05/05/20
  3100. 8
    Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
    3-V Biosciences
    05/05/20
  3101. 54
    Substituted [1,2,4]triazolo[1,5-a]pyrazines as phosphodiesterase inhibitors
    Sunovion Pharmaceuticals
    05/05/20
  3102. 33
    Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
    Principia Biopharma
    05/05/20
  3103. 43
    Trk-inhibiting compound
    Ono Pharmaceutical
    05/05/20
  3104. 13
    7-beta-alkyl analogs of orvinols
    Purdue Pharma
    04/30/20
  3105. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda
    04/30/20
  3106. 24
    5,5-bicyclic oxazole orexin receptor antagonists
    Merck Sharp & Dohme
    04/25/20
  3107. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
    Jenrin Discovery
    04/25/20
  3108. 33
    Inhibitors of lysine gingipain
    Cortexyme
    04/25/20
  3109. 31
    Pharmaceutical composition comprising pyridone derivatives
    Sk Biopharmaceuticals
    04/25/20
  3110. 41
    Pharmaceutical composition for treating FLT3 mutation-positive cancer, mutant FLT3 inhibitor and uses thereof
    Fujifilm
    04/25/20
  3111. 5
    Primary amines and derivitves thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    04/25/20
  3112. 239
    Substituted 2,4-diaminopyrimidines as kinase inhibitors
    Celgene Car
    04/25/20
  3113. 29
    3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors
    Janssen Pharmaceutica
    04/18/20
  3114. 124
    GDF-8 inhibitors
    Rigel Pharmaceuticals
    04/18/20
  3115. 73
    IRE-1α inhibitors
    Fosun Orinove Pharmatech
    04/18/20
  3116. 146
    Pyrrolotriazine compounds as tam inhibitors
    Incyte
    04/18/20
  3117. 296
    Serotonin receptor modulators
    Janssen Pharmaceutica
    04/18/20
  3118. 74
    Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors
    Merck Patent
    04/18/20
  3119. 116
    Triazoles as NR2B receptor inhibitors
    Janssen Pharmaceuticals
    04/18/20
  3120. 10
    Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
    Newlink Genetics
    04/18/20
  3121. 73
    Trifluoromethylpropanamide derivatives
    Hoffman-La Roche
    04/18/20
  3122. 17
    β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activators
    Samumed
    04/15/20
  3123. 23
    1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
    Takeda Pharmaceutical
    04/15/20
  3124. 40
    1H-pyrrol-3-amines
    Bayer Pharma Aktiengesellschaft
    04/15/20
  3125. 18
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences
    04/15/20
  3126. 80
    Aromatic heterocyclic compound
    Mitsubishi Tanabe Pharma
    04/15/20
  3127. 170
    Compounds and compositions for inhibiting the activity of SHP2
    Novartis
    04/15/20
  3128. 3
    Fucosidase inhibitors
    Horizon Orphan
    04/15/20
  3129. 10
    Heterocyclic compounds and methods for their use
    Novartis
    04/15/20
  3130. 267
    Heterocyclic compounds as immunomodulators
    Incyte
    04/15/20
  3131. 163
    Heterocyclic compounds as inhibitors of Vanin-1 enzyme
    Pfizer
    04/15/20
  3132. 3
    Inhibitors of PTP4A3 for the treatment of cancer
    University Of Virginia Patent Foundation
    04/15/20
  3133. 15
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Syros Pharmaceuticals
    04/15/20
  3134. 18
    Methods of use of cyclopamine analogs
    Infinity Pharmaceuticals
    04/15/20
  3135. 74
    Muscarinic M1 receptor positive allosteric modulators
    Suven Life Sciences
    04/15/20
  3136. 167
    Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
    Boehringer Ingelheim International
    04/15/20
  3137. 43
    Piperidine oxadiazole and thiadiazole orexin receptor antagonists
    Merck Sharp & Dohme
    04/15/20
  3138. 18
    Preparation and use of kinase inhibitor
    Changzhou Longthera Pharmaceuticals
    04/15/20
  3139. 14
    Proton pump inhibitors
    Takeda Pharmaceutical
    04/15/20
  3140. 121
    Pyridine derivatives
    Hoffmann-La Roche
    04/15/20
  3141. 34
    Pyridinyl and fused pyridinyl triazolone derivatives
    Takeda Pharmaceutical
    04/15/20
  3142. 22
    Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
    Bayer Pharma Aktiengesellschaft
    04/15/20
  3143. 673
    Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
    Epizyme
    04/15/20
  3144. 16
    Therapeutic compounds and compositions, and methods of use thereof
    Genentech
    04/15/20
  3145. 238
    Therapeutic compounds and uses thereof
    Genentech
    04/15/20
  3146. 310
    Therapeutic inhibitory compounds
    Lifesci Pharmaceuticals
    04/15/20
  3147. 28
    Thienopyranones as kinase and epigenetic inhibitors
    Signal Rx Pharmaceuticals
    04/15/20
  3148. 60
    Tricyclic heterocyclic compounds useful as inhibitors of TNF
    Bristol-Myers Squibb
    04/15/20
  3149. 31
    2-pyridyloxy-3-ester-4-ether orexin receptor antagonists
    Merck Sharp & Dohme
    04/10/20
  3150. 36
    Aromatic heterocyclic derivatives and pharmaceutical applications thereof
    Sunshine Lake Pharma
    04/10/20
  3151. 2
    Arylpiperazine derivatives and methods of utilizing same
    Reviva Pharmaceuticals
    04/10/20
  3152. 10
    Benzimidazole derivatives and use thereof
    Purdue Pharma
    04/10/20
  3153. 3
    Benzomorphan analogs and use thereof
    Purdue Pharma
    04/10/20
  3154. 11
    Compounds for the inhibition of cyclophilins and uses thereof
    Merck Patent
    04/10/20
  3155. 4
    Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer''s disease
    Fondazione Istituto Itaiano Di Tecnologia
    04/10/20
  3156. 44
    Factor XIa inhibitors
    Merck Sharp & Dohme
    04/10/20
  3157. 63
    Heteroaromatic compounds as BTK inhibitors
    Boehringer Ingelheim International
    04/10/20
  3158. 80
    Pyrimidinones as PI3K inhibitors
    Incyte Holdings
    04/10/20
  3159. 50
    3-(4-(benzyloxy)phenyl)hex-4-ynoic acid derivative, method of preparing same and pharmaceutical composition for preventing and treating metabolic disease including same as effective ingredient
    Hyundai Pharm
    04/06/20
  3160. 122
    Compounds useful as CCR9 modulators
    Norgine
    04/06/20
  3161. 53
    Factor IXa inhibitors
    Merck Sharp & Dohme
    04/06/20
  3162. 166
    Inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    04/06/20
  3163. 190
    Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof
    Sanford-Burnham Medical Research Institute
    04/06/20
  3164. 6
    N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
    Ogeda
    04/06/20
  3165. 8
    P2X4 receptor antagonist
    Nippon Chemiphar
    04/06/20
  3166. 10
    Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    04/06/20
  3167. 9
    Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
    Wisconsin Alumni Research Foundation
    04/06/20
  3168. 130
    Urea and amide derivatives of aminoalkylpiperazines and use thereof
    Southern Research Institute
    04/06/20
  3169. 1
    Morphinan derivative
    University Of Tsukuba
    03/30/20
  3170. 117
    N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof
    Northeastern University
    03/30/20
  3171. 220
    N-arylmethyl sulfonamide negative modulators of NR2A
    Luc Therapeutics
    03/30/20
  3172. 26
    Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
    Genentech
    03/30/20
  3173. 40
    Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
    Taiho Pharmaceutical
    03/30/20
  3174. 45
    Pyrrolopyrimidine compounds used as TLR7 agonist
    Chia Tai Tianqing Pharmaceutical Group
    03/30/20
  3175. 13
    Radiolabeled compounds
    Takeda Pharmaceutical
    03/30/20
  3176. 18
    Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase
    University Of Washington Through Its Center For Commercialization
    03/30/20
  3177. 43
    Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators
    Laboratorios Del Dr. Esteve
    03/30/20
  3178. 15
    Sulfonamide compounds for inhibition of metastatic tumor growth
    Welichem Biotech
    03/30/20
  3179. 12
    Use of small molecule inhibitors targeting EYA tyrosine phosphatase
    Cincinnati Childrens Hospital Medical Center
    03/30/20
  3180. 25
    Compositions and methods of modulating 15-PGDH activity
    University Of Kentucky Research Foundation
    03/26/20
  3181. 63
    Heteroaromatic derivatives and their use as pharmaceuticals
    Mutabilis
    03/26/20
  3182. 61
    Histone deacetylase inhibitors
    Biomarin Pharmaceutical
    03/26/20
  3183. 31
    Imidazole derivative having JNK inhibitory activity and use thereof
    Samjin Pharmaceutical
    03/26/20
  3184. 365
    Inhibitors of ERK and methods of use
    Kura Oncology
    03/26/20
  3185. 15
    Kinase inhibitors
    Topivert Pharma
    03/26/20
  3186. 33
    Phosphonate compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    03/26/20
  3187. 33
    Piperazine derivative
    Astellas Pharma
    03/26/20
  3188. 180
    Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors
    Bristol-Myers Squibb
    03/26/20
  3189. 62
    Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
    Guangzhou Innocare Pharma Tech
    03/26/20
  3190. 139
    Therapeutic inhibitory compounds
    Lifesci Pharmaceuticals
    03/26/20
  3191. 54
    1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2
    Novartis
    03/25/20
  3192. 14
    CGRP receptor antagonists
    Heptares Therapeutics
    03/25/20
  3193. 306
    Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ]
    Phenex Pharmaceuticals
    03/25/20
  3194. 153
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    03/25/20
  3195. 61
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    03/25/20
  3196. 41
    Imidazole derivatives as formyl peptide receptor modulators
    Allergan
    03/25/20
  3197. 118
    Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
    Zhejiang Dtrm Biopharma
    03/25/20
  3198. 53
    Tetrahydropyridopyrimidine compound or salt thereof
    Taiho Pharmaceutical
    03/25/20
  3199. 87
    Therapeutic compounds and uses thereof
    Genentech
    03/25/20
  3200. 53
    Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation
    Universitat Bern
    03/25/20
  3201. 43
    Trk-inhibiting compound
    Ono Pharmaceutical
    03/25/20
  3202. 18
    Tyrosine kinase inhibitor and uses thereof
    Xuanzhu Pharma
    03/25/20
  3203. 40
    Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy
    Sanford Burnham Prebys Medical Discovery Institute
    03/25/20
  3204. 88
    1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte
    03/23/20
  3205. 103
    5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum
    University Of Washington Through Its Center For Commercialization
    03/23/20
  3206. 59
    6-amino-5,6,7,8-tetrahydronaphthalen-2-yl or 3-aminochroman-7-yl derivatives
    Hoffman-La Roche
    03/23/20
  3207. 139
    Benzimidazol-2-amines as mIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    03/23/20
  3208. 184
    Bromodomain inhibitors
    Abbvie
    03/23/20
  3209. 44
    CDK inhibitors
    Gi Therapeutics
    03/23/20
  3210. 4
    Compounds for the treatment of cancer and inflammatory diseases
    TBA
    03/23/20
  3211. 423
    Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors
    Merck Sharp & Dohme
    03/23/20
  3212. 75
    N-(2-cyano heterocyclyl) pyrazolo pyridones as janus kinase inhibitors
    Merck Sharp & Dohme
    03/23/20
  3213. 21
    Selective histone deactylase 6 inhibitors
    H. Lee Moffitt Cancer Center And Research Institute
    03/23/20
  3214. 61
    Substituted nicotinamide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
    Beijing Innocare Pharma Tech
    03/18/20
  3215. 147
    8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives
    Idorsia Pharmaceuticals
    03/16/20
  3216. 116
    Aminopyridazinone compounds as protein kinase inhibitors
    Jiangsu Hengrui Medicine
    03/16/20
  3217. 346
    Benzimidazol-2-amines as MIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    03/16/20
  3218. 219
    Dihydropyridone P1 as factor XIa inhibitors
    Bristol-Myers Squibb
    03/16/20
  3219. 13
    Heterocyclic vinyl autotaxin inhibitor compounds
    Pharmakea
    03/16/20
  3220. 305
    Indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments
    Bayer Pharma Aktiengesellschaft
    03/16/20
  3221. 25
    Inhibitors of beta-secretase
    Vitae Pharmaceuticals
    03/16/20
  3222. 236
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    03/16/20
  3223. 35
    Mammalian and bacterial nitric oxide synthase inhibitors
    Northwestern University
    03/16/20
  3224. 28
    Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors
    Iteos Therapeutics
    03/16/20
  3225. 3
    Selective matrix metalloproteinase inhibitors
    University Of Notre Dame Du Lac
    03/16/20
  3226. 63
    Styryl quinazoline derivatives as pharmaceutically active agents
    Vichem Chemie Kutató
    03/16/20
  3227. 23
    Tertiary amines for use in the treatment of cardiac disorders
    Universitetet I Oslo
    03/16/20
  3228. 43
    (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
    Oryzon Genomics
    03/12/20
  3229. 109
    Bicyclic azaheterocyclobenzylamines as PI3K inhibitors
    Incyte Holdings
    03/12/20
  3230. 5
    Cannabinoid receptor modulators
    Arena Pharmaceuticals
    03/12/20
  3231. 8
    Factor XIa inhibitors
    Merck Sharp & Dohme
    03/12/20
  3232. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte
    03/12/20
  3233. 205
    Imidazotriazines and imidazopyrimidines as kinase inhibitors
    Incyte
    03/12/20
  3234. 167
    Inhibiting neurotransmitter reuptake
    Mayo Foundation
    03/12/20
  3235. 17
    Inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    03/12/20
  3236. 103
    Oxazole compound and pharmaceutical composition
    Otsuka Pharmaceutical
    03/12/20
  3237. 61
    Substituted amino triazoles useful as human chitinase inhibitors
    Oncoarendi Therapeutics
    03/12/20
  3238. 57
    1, 3, 4-thiadiazole compounds and their use in treating cancer
    Astrazeneca
    03/10/20
  3239. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    03/10/20
  3240. 150
    4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity
    Virostatics
    03/10/20
  3241. 21
    Compounds
    University Court Of The University Of Edinburgh
    03/10/20
  3242. 2
    Compounds as rearranged during transfection (RET) inhibitors
    Glaxosmithkline
    03/10/20
  3243. 27
    Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators
    Suven Life Sciences
    03/10/20
  3244. 398
    Heteroaryl substituted aminopyridine compounds
    Bristol-Myers Squibb
    03/10/20
  3245. 273
    Inhibitors of the kynurenine pathway
    Curadev Pharma
    03/10/20
  3246. 47
    Oxazoline and isoxazoline derivatives as CRAC modulators
    Lupin
    03/10/20
  3247. 3
    Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
    Tianjin Institute Of Pharmaceutical Research
    03/10/20
  3248. 80
    Positive allosteric modulators of human melanocortin-4 receptor
    Vanderbilt University
    03/10/20
  3249. 129
    Quinolone derivatives as fibroblast growth factor receptor inhibitors
    Principia Biopharma
    03/10/20
  3250. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica
    03/10/20
  3251. 135
    Substituted boronic acids and boronate esters as immunoproteasome inhibitors
    Merck Patent
    03/10/20
  3252. 36
    TGF beta receptor antagonists
    Bristol-Myers Squibb
    03/10/20
  3253. 33
    1,3,4-thiadiazole compounds and their use in treating cancer
    Astrazeneca
    03/02/20
  3254. 81
    6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
    Merck Sharp & Dohme
    03/02/20
  3255. 34
    C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof
    Merck Patent
    03/02/20
  3256. 116
    Cyclopropanecarboxylic acid GPR120 modulators
    Bristol-Myers Squibb
    03/02/20
  3257. 668
    Heterocyclic inhibitors of glutaminase
    Calithera Biosciences
    03/02/20
  3258. 34
    Hydrazine compound as blood coagulation factor Xa inhibitor
    North China Pharmaceutical
    03/02/20
  3259. 22
    Naphthyridine compounds, medical combinations and use thereof
    Nanjing Natinefy Pharmatech
    03/02/20
  3260. 25
    Substituted heteroaryl compounds and methods of use
    Calitor Sciences
    03/02/20
  3261. 9
    Therapeutic pyrazolyl thienopyridines
    Fbm Therapeutics
    03/02/20
  3262. 13
    Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
    Karus Therapeutics
    03/02/20
  3263. 260
    Compounds
    Takeda Pharmaceutical
    02/29/20
  3264. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical
    02/29/20
  3265. 70
    3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof
    Samumed
    02/27/20
  3266. 66
    3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
    Samumed
    02/27/20
  3267. 43
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University Of The Commonwealth System Of Higher Education
    02/27/20
  3268. 3
    Amino pyrimidine SSAO inhibitors
    Eli Lilly
    02/27/20
  3269. 698
    Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals
    02/27/20
  3270. 22
    Bicyclic heterocyclic compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    02/27/20
  3271. 129
    CXCR7 antagonists
    Chemocentryx
    02/27/20
  3272. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
    Astrazeneca
    02/27/20
  3273. 14
    Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies
    Galderma Research & Development
    02/27/20
  3274. 30
    Compounds for treatment of fibrosis diseases
    Curegenix
    02/27/20
  3275. 64
    Heterocyclic derivatives as modulators of kinase activity
    Merck Patent
    02/27/20
  3276. 4
    Imidazolyl kinase inhibitors and uses thereof
    Dana-Farber Cancer Institute
    02/27/20
  3277. 39
    Inhibitors of human 12/15-lipoxygenase
    The Children'S Hospital
    02/27/20
  3278. 304
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    02/27/20
  3279. 35
    Morphan and morphinan analogues, and methods of use
    Alkermes Pharma Ireland
    02/27/20
  3280. 197
    Pyrimidinone amide compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    02/27/20
  3281. 126
    Substituted indazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    02/27/20
  3282. 261
    Substituted piperidine compound and use thereof
    Takeda Pharmaceutical
    02/27/20
  3283. 51
    Substituted pyrimidines containing acidic groups as TLR7 modulators
    Apros Therapeutics
    02/27/20
  3284. 303
    TGF-β inhibitors
    Rigel Pharmaceuticals
    02/27/20
  3285. 125
    2-(1H-indazol-3-yl)-3H-imidazo[4,5-B]pyridine and therapeutic uses thereof
    Samumed
    02/24/20
  3286. 14
    Benzimidazole derivatives as RLK and ITK inhibitors
    Principia Biopharma
    02/24/20
  3287. 166
    Compounds, compositions, and methods
    Denali Therapeutics
    02/24/20
  3288. 2
    FXR (NR1H4) modulating compounds
    Gilead Sciences
    02/24/20
  3289. 98
    Heterocyclic inhibitors of PTPN11
    The University Of Texas System
    02/24/20
  3290. 69
    Heterocyclic kinase inhibitors
    Abbvie
    02/24/20
  3291. 101
    Inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    02/24/20
  3292. 39
    Purine derivatives for the treatment of viral infections
    Janssen Ireland
    02/24/20
  3293. 5
    Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
    The Council Of Scientific & Industrial Research
    02/24/20
  3294. 7
    Syk inhibitors
    Gilead Sciences
    02/24/20
  3295. 112
    Use of pyrazolopyrimidine derivatives for the treatment of PI3K-delta related disorders
    Incyte
    02/24/20
  3296. 15
    Combination therapy with glutaminase inhibitors
    Calithera Biosciences
    02/21/20
  3297. 36
    Identification of stabilizers of multimeric proteins
    The Board Of Trustees Of The Leland Stanford Junior University
    02/21/20
  3298. 26
    Phthalazinone compounds and methods for the treatment of cystic fibrosis
    Flatley Discovery Lab
    02/21/20
  3299. 16
    Pyrazolopyridone compounds and uses thereof
    Incyte
    02/21/20
  3300. 213
    Pyridazine derivatives as RORc modulators
    Genentech
    02/21/20
  3301. 40
    Pyridopyrimidinones and methods of use thereof
    Genentech
    02/21/20
  3302. 183
    Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
    Forma Tm2
    02/21/20
  3303. 2
    Salt of fused pyrimidine compound and crystal thereof
    Taiho Pharmaceutical
    02/21/20
  3304. 172
    Serine/threonine kinase inhibitors
    Genentech
    02/21/20
  3305. 219
    Therapeutic compounds and uses thereof
    Genentech
    02/21/20
  3306. 11
    Tricyclic analogues, preparation method and uses thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    02/21/20
  3307. 26
    Compounds that are S1P modulating agents and/or ATX modulating agents
    Biogen Ma
    02/20/20
  3308. 163
    Histone demethylase inhibitors
    Celgene Quantscel Research
    02/20/20
  3309. 475
    Inhibitors of glucocorticoid receptor translocation
    Sanford Burnham Prebys Medical Discovery Institute
    02/20/20
  3310. 5
    Metabolites of N-{4-([6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
    Exelixis
    02/20/20
  3311. 180
    NHE3-binding compounds and methods for inhibiting phosphate transport
    Ardelyx
    02/20/20
  3312. 83
    NRF2 regulators
    Glaxosmithkline
    02/20/20
  3313. 14
    Piperidinone carboxamide azaindane CGRP receptor antagonists
    Merck Sharp & Dohme
    02/20/20
  3314. 8
    Pteridines as FGFR inhibitors
    Astex Therapeutics
    02/20/20
  3315. 21
    Pyrazines as modulators of GPR6
    Takeda Pharmaceutical
    02/20/20
  3316. 389
    Substituted 6,5-fused bicyclic heteroaryl compounds
    Epizyme
    02/20/20
  3317. 173
    Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators
    Indivior
    02/20/20
  3318. 15
    Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
    Piramal Enterprises
    02/20/20
  3319. 39
    Subunit selective NMDA receptor potentiators for the treatment of neurological conditions
    Emory University
    02/20/20
  3320. 804
    Tricyclic sulfones as RORγ modulators
    Bristol-Myers Squibb
    02/20/20
  3321. 15
    2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof
    Shanghai Haiyan Pharmaceutical Technology
    02/16/20
  3322. 130
    Aldosterone synthase inhibitors
    Boehringer Ingelheim International
    02/16/20
  3323. 23
    Benzazepine sulfonamide compounds
    Hoffmann-La Roche
    02/16/20
  3324. 52
    Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
    Incyte
    02/16/20
  3325. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    02/16/20
  3326. 3
    Compounds I
    Proximagen
    02/16/20
  3327. 168
    Imidazopyrrolidine derivatives and their use in the treatment of disease
    Novartis
    02/16/20
  3328. 169
    Urea derivatives useful as kinase inhibitors
    Respivert
    02/16/20
  3329. 451
    5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
    Galapagos
    02/10/20
  3330. 13
    Bipyrazole derivatives as JAK inhibitors
    Incyte
    02/10/20
  3331. 33
    Inhibition of MCL-1 and/or BFL-1/A1
    Dana-Farber Cancer Institute
    02/10/20
  3332. 53
    Inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    02/10/20
  3333. 34
    Inhibitors of bruton's tyrosine kinase
    Centaurus Biopharma
    02/10/20
  3334. 401
    Phthalazinones and isoquinolinones as rock inhibitors
    Bristol-Myers Squibb
    02/10/20
  3335. 53
    Tetracyclic autotaxin inhibitors
    Pharmakea
    02/10/20
  3336. 11
    2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
    Gilead Sciences
    02/07/20
  3337. 22
    2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof
    Merck Patent
    02/07/20
  3338. 27
    3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof
    St. Chuan University
    02/07/20
  3339. 71
    6-membered cyclic amines or lactames substituted with urea and phenyl
    GrÜNenthal
    02/07/20
  3340. 26
    Bacterial topoisomerase I inhibitors with antibacterial activity
    The Florida International University Board Of Trustees
    02/07/20
  3341. 109
    Bicyclic azaheterocyclobenzylamines as PI3K inhibitors
    Incyte
    02/07/20
  3342. 64
    Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
    Enanta Pharmaceuticals
    02/07/20
  3343. 13
    Branched 3-phenylpropionic acid derivatives and their use
    Bayer Intellectual Property
    02/07/20
  3344. 134
    Bruton's tyrosine kinase inhibitors
    Pfizer
    02/07/20
  3345. 168
    Carbazole derivatives
    Bristol-Myers Squibb
    02/07/20
  3346. 118
    Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof
    Sunshine Lake Pharma
    02/07/20
  3347. 26
    Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
    Guangzhou Maxinovel Pharmaceuticals
    02/07/20
  3348. 18
    EZH2 inhibitors
    Mirati Therapeutics
    02/07/20
  3349. 29
    Inhibitor of FLT3 kinase and use thereof
    Hefei Institutes Of Physical Science, Chinese Academy Of Sciences
    02/07/20
  3350. 4
    Psychotropic agents and uses thereof
    Lb Pharmaceuticals
    02/07/20
  3351. 932
    Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer
    Epizyme
    02/07/20
  3352. 187
    Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases
    Bayer Intellectual Property
    02/07/20
  3353. 258
    Tank-binding kinase inhibitor compounds
    Gilead Sciences
    02/07/20
  3354. 144
    Therapeutic inhibitory compounds
    Lifesci Pharmaceuticals
    02/07/20
  3355. 106
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
    Incyte
    02/07/20
  3356. 70
    Thioacetate compounds, compositions and methods of use
    Ardea Biosciences
    02/07/20
  3357. 343
    ULK1 inhibitors and methods using same
    Salk Institute
    02/07/20
  3358. 155
    Compounds and their use as BACE inhibitors
    Astrazeneca
    02/04/20
  3359. 109
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    02/04/20
  3360. 168
    Heterocyclic compounds useful as pim kinase inhibitors
    Incyte
    02/04/20
  3361. 218
    Indole carboxamide compounds
    Bristol-Myers Squibb
    02/04/20
  3362. 30
    Methyl oxazole orexin receptor antagonists
    Merck Sharp & Dohme
    02/04/20
  3363. 104
    Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
    Pfizer
    02/04/20
  3364. 35
    N-(hetero)aryl-substituted heteroyclic derivatives useful for the treatment of diseases or conditions related to the central nervous system
    Chronos Therapeutics
    02/04/20
  3365. 79
    Pyrazolo[3,4-d]pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    02/04/20
  3366. 2
    Pyridone derivatives as rearranged during transfection (RET) kinase inhibitors
    Glaxosmithkline
    02/04/20
  3367. 14
    Substituted oxopyridine derivatives and use thereof as factor XIa/plasma
    Bayer Pharma Aktiengesellschaft
    02/04/20
  3368. 111
    Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
    Incyte
    02/04/20
  3369. 78
    Heteroaryl Syk inhibitors
    Boehringer Ingelheim International
    01/30/20
  3370. 30
    Naphthylamide compound, preparation method and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    01/30/20
  3371. 156
    Pyrazolo[1,5-a]pyridine derivatives and methods of their use
    Ignyta
    01/30/20
  3372. 113
    TrKA kinase inhibitors, compositions and methods thereof
    Merck Sharp & Dohme
    01/30/20
  3373. 404
    Tricyclic pyrido-carboxamide derivatives as rock inhibitors
    Bristol-Myers Squibb
    01/30/20
  3374. 11
    Use of benzimidazole-proline derivatives
    Idorsia Pharmaceuticals
    01/30/20
  3375. 45
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences
    01/27/20
  3376. 65
    Aryl ethers and uses thereof
    Peloton Therapeutics
    01/27/20
  3377. 132
    Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof
    Agency For Science, Technology And Research
    01/27/20
  3378. 48
    Histone deacetylase inhibitors
    Biomarin Pharmaceutical
    01/27/20
  3379. 154
    Histone demethylase inhibitors
    Celgene Quanticel Research
    01/27/20
  3380. 198
    Kinase inhibitors and method of treating cancer
    University Health Network
    01/27/20
  3381. 8
    Methods to treat lymphoplasmacytic lymphoma
    Dana-Farber Cancer Institute
    01/27/20
  3382. 84
    Spirocyclic derivatives
    Chronos Therapeutics
    01/27/20
  3383. 88
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte
    01/27/20
  3384. 32
    1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions
    Sabila Biosciences
    01/21/20
  3385. 135
    4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica
    01/21/20
  3386. 41
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals
    01/21/20
  3387. 65
    Aryl ethers and uses thereof
    Peloton Therapeutics
    01/21/20
  3388. 5
    Assays for screening for or identifying an agent or molecule that can block or inhibit AVB3 integrin from forming a complex with KRAS
    The Regents Of The University Of California
    01/21/20
  3389. 101
    Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
    Novartis
    01/21/20
  3390. 330
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    01/21/20
  3391. 234
    Biaryl kinase inhibitors
    Bristol-Myers Squibb
    01/21/20
  3392. 186
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    01/21/20
  3393. 88
    Chemokine receptor modulators and uses thereof
    Flx Bio
    01/21/20
  3394. 243
    Compounds, compositions and methods
    Denali Therapeutics
    01/21/20
  3395. 9
    Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors
    Palobiofarma
    01/21/20
  3396. 18
    Diaryl macrocycles as modulators of protein kinases
    Tp Therapeutics
    01/21/20
  3397. 57
    Fused tricyclic compounds as Raf kinase inhibitors
    Beigene
    01/21/20
  3398. 106
    Histone demethylase inhibitors
    Celgene Quanticel Research
    01/21/20
  3399. 509
    IRAK4 inhibiting agents
    Biogen Ma
    01/21/20
  3400. 53
    Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    01/21/20
  3401. 28
    Indazole and azaindazole Btk inhibitors
    Merck Sharp & Dohme
    01/21/20
  3402. 51
    Inhibiting G protein coupled receptor 6 kinase polypeptides
    Mayo Foundation
    01/21/20
  3403. 31
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    01/21/20
  3404. 46
    Macrocyclic compounds as TRK kinase inhibitors
    Array Biopharma
    01/21/20
  3405. 227
    N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators
    Novartis
    01/21/20
  3406. 31
    N-pyrrolidinyl,N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
    Array Biopharma
    01/21/20
  3407. 13
    Polysubstituted pyridine compound, preparation method, use and pharmaceutical composition
    Peking University Founder Group
    01/21/20
  3408. 85
    Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
    Forma Tm2
    01/21/20
  3409. 4
    Pyridone-sulfone morphinan analogs as opioid receptor ligands
    Purdue Pharma
    01/21/20
  3410. 7
    Quinoxaline derivatives useful as FGFR kinase modulators
    Astex Therapeutics
    01/21/20
  3411. 57
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
    Boehringer Ingelheim International
    01/21/20
  3412. 168
    Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
    Exonhit Therapeutics
    01/21/20
  3413. 365
    Substituted prolines/piperidines as orexin receptor antagonists
    Eolas Therapeutics
    01/21/20
  3414. 232
    Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array Biopharm
    01/21/20
  3415. 609
    Tank-binding kinase inhibitor compounds
    Gilead Sciences
    01/21/20
  3416. 46
    TrkA kinase inhibitors, compositions and methods thereof
    Merck Sharp & Dohme
    01/21/20
  3417. 32
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors
    Respivert
    12/30/19
  3418. 620
    2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
    Cancer Research Technology
    12/30/19
  3419. 16
    3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
    Parion Sciences
    12/30/19
  3420. 22
    4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
    Heptares Therapeutics
    12/30/19
  3421. 132
    4-imidazopyridazin-1-yl-benzamides as BTK inhibitors
    Merck Sharp & Dohme
    12/30/19
  3422. 43
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University Of The Commonwealth System Of Higher Education
    12/30/19
  3423. 22
    Benzoazepine derivatives
    Viiv Healthcare
    12/30/19
  3424. 48
    Benzothiazole and benzothiophene compounds
    Universite De Montreal
    12/30/19
  3425. 1057
    Biaryl amide compounds as kinase inhibitors
    Novartis
    12/30/19
  3426. 49
    C5-C6-fused tricyclic iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
    TBA
    12/30/19
  3427. 190
    Dopamine D3 receptor antagonists
    Indivior
    12/30/19
  3428. 53
    Heteroaryl orexin receptor antagonists
    Merck Sharp & Dohme
    12/30/19
  3429. 12
    Liver X receptor (LXR) modulators
    Ralexar Therapeutics
    12/30/19
  3430. 357
    Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
    Boehringer Ingelheim International
    12/30/19
  3431. 141
    N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B
    Cadent Therapeutics
    12/30/19
  3432. 75
    Positive allosteric modulators of the muscarinic acetylcholine receptor M4
    Vanderbilt University
    12/30/19
  3433. 25
    RIPK2 inhibitors and method of treating cancer with same
    University Health Network
    12/30/19
  3434. 86
    Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors
    Dart Neuroscience (Cayman
    12/30/19
  3435. 243
    Sulfonamide compounds as voltage-gated sodium channel modulators
    Lupin
    12/30/19
  3436. 58
    Therapeutic compounds and uses thereof
    Genetech
    12/30/19
  3437. 169
    Triaza-spirodecanones as DDR1 inhibitors
    Hoffman-La Roche
    12/30/19
  3438. 240
    Triazole compounds as T-type calcium channel blockers
    Idorsia Pharmaceuticals
    12/30/19
  3439. 76
    Triterpenoids with HIV maturation inhibitory activity
    Viiv Healthcare Uk (No. 4
    12/30/19
  3440. 248
    Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
    Amgen
    12/30/19
  3441. 287
    3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
    Bayer Pharma Aktiengesellschaft
    12/27/19
  3442. 57
    9-membered fused ring derivative
    Shionogi
    12/27/19
  3443. 8
    Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
    Oryzon Genomics
    12/27/19
  3444. 45
    Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    University Of California
    12/27/19
  3445. 217
    CDK2/4/6 inhibitors
    Pfizer
    12/27/19
  3446. 650
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    12/27/19
  3447. 159
    Compounds and their use as BACE inhibitors
    Astrazeneca
    12/27/19
  3448. 49
    Compounds for use as GPR120 agonists
    Piramal Enterprises
    12/27/19
  3449. 130
    Compounds useful for treating disorders related to RET
    Blueprint Medicines
    12/27/19
  3450. 13
    Cystathionine-gamma-lyase (CSE) inhibitors
    Sova Pharmaceuticals
    12/27/19
  3451. 6
    Enantiomers of the 1′,6′-isomer of neplanocin A
    Auburn University
    12/27/19
  3452. 8
    Estrogen receptor modulators and uses thereof
    Genentech
    12/27/19
  3453. 47
    Fused bicyclic compounds for the treatment of disease
    Akarna Therapeutics
    12/27/19
  3454. 76
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    12/27/19
  3455. 6
    Ghrelin 0-acyl transferase inhibitors
    Eli Lilly
    12/27/19
  3456. 46
    Glucosylceramide synthase inhibitors for the treatment of diseases
    Biomarin Pharmaceutical
    12/27/19
  3457. 99
    Heteroaryl compounds for kinase inhibition
    Ariad Pharmaceuticals
    12/27/19
  3458. 337
    Heterocyclic modulators of lipid synthesis and combinations thereof
    3-V Biosciences
    12/27/19
  3459. 157
    IDO inhibitors
    Newlink Genetics
    12/27/19
  3460. 145
    Inhibiting agents for bruton's tyrosine kinase
    Biogen Ma
    12/27/19
  3461. 11
    Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety
    Universitetet | Oslo
    12/27/19
  3462. 109
    Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    12/27/19
  3463. 158
    LSD1 inhibitors
    Mirati Therapeutics
    12/27/19
  3464. 369
    Metallo-beta-lactamase inhibitors
    Merck Sharp & Dohme
    12/27/19
  3465. 39
    Methods for treating depressive symptoms
    Alkermes Pharma Ireland
    12/27/19
  3466. 104
    Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use therof
    Pfizer
    12/27/19
  3467. 129
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    12/27/19
  3468. 16
    Pyrazole orexin receptor antagonists
    Merck Sharp & Dohme
    12/27/19
  3469. 24
    Selective histone deactylase 6 inhibitors
    H. Lee Moffitt Cancer Center And Research Institute
    12/27/19
  3470. 75
    Small molecule NF-κB inhibitors
    Immunetarget
    12/27/19
  3471. 642
    Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
    Janssen Pharmaceutica
    12/27/19
  3472. 136
    Substituted benzenesulfonamides as sodium channel blockers
    Daewoong Pharmaceutical
    12/27/19
  3473. 75
    Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors
    Merck Patent
    12/27/19
  3474. 243
    Substituted spirocyclic inhibitors of autotaxin
    X-Rx
    12/27/19
  3475. 4
    T-type calcium channel modulator and uses thereof
    Uti Limited Partnership
    12/27/19
  3476. 25
    TRPV1 vanilloid receptor antagonists with a bicyclic portion
    TBA
    12/27/19
  3477. 26
    Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
    Bristol-Myers Squibb
    12/27/19
  3478. 28
    Tricyclic heterocycles as bet protein inhibitors
    Incyte
    12/27/19
  3479. 292
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    12/19/19
  3480. 307
    Methods of treatment using pyridinonyl PDK1 inhibitors
    Sunesis Pharmaceuticals
    12/19/19
  3481. 43
    P2X4 receptor antagonist
    Nippon Chemiphar
    12/19/19
  3482. 774
    Triazolopyridine compounds, compositions and methods of use thereof
    Genentech
    12/19/19
  3483. 47
    Heterocycles as modulators of kinase activity
    Merck Patent
    12/12/19
  3484. 72
    Pyridyl benzothiophenes as kinase inhibitors
    Allergan
    12/12/19
  3485. 92
    C-linked heterocycloaklyl substituted pyrimidines and their uses
    Genentech
    12/10/19
  3486. 51
    Diazine-fused amidines as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    12/10/19
  3487. 19
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    12/10/19
  3488. 214
    Inhibitors of protein kinases
    Portola Pharmaceuticals
    12/10/19
  3489. 185
    Serine/threonine kinase inhibitors
    Genentech
    12/10/19
  3490. 110
    Thiazolopyrrolidine inhibitors of ROR- γ
    Vitae Pharmaceuticals
    12/10/19
  3491. 7
    Hydrophobically tagged janus kinase inhibitors and uses thereof
    Dana-Farber Cancer Institute
    12/03/19
  3492. 393
    Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
    Bristol-Myers Squibb
    12/03/19
  3493. 7
    Indolyl-containing RORγt inhibitors
    Orca Pharmaceuticals
    12/03/19
  3494. 20
    Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
    Purdue Pharma
    12/03/19
  3495. 58
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health
    12/03/19
  3496. 13
    Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
    Novartis
    12/03/19
  3497. 13
    Tetrahydrocarboline derivative
    Ono Pharmaceutical
    12/03/19
  3498. 83
    TrkA kinase inhibitors, compositions and methods thereof
    Merck Sharp & Dohme
    12/03/19
  3499. 106
    2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase
    Cancer Therapeutics Crc
    11/21/19
  3500. 340
    Aminoquinazoline and pyridopyrimidine derivatives
    Genentech
    11/21/19
  3501. 38
    Carboxylic acid compound, method for preparation thereof, and use thereof
    Inventisbio Shanghai
    11/21/19
  3502. 39
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    11/21/19
  3503. 124
    Inhibitor compounds of phosphodiesterase type 10A
    Abbvie Deutschland
    11/21/19
  3504. 68
    Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2)
    Sanofi
    11/21/19
  3505. 42
    Substituted pyrazolo[1,5-a]pyridines as PDE-10 inhibitors
    Sunovion Pharmaceuticals
    11/21/19
  3506. 57
    Substituted tropane derivatives
    Toa Eiyo
    11/21/19
  3507. 11
    Treatment of respiratory disorders using ROR-gamma inhibitors
    Glenmark Pharmaceuticals
    11/21/19
  3508. 5
    1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties
    The Regents Of The University Of Michigan
    11/14/19
  3509. 122
    Autotaxin inhibitor compounds
    Pharmakea
    11/14/19
  3510. 375
    Compounds useful as immunomodulators
    Bristol-Myers Squibb
    11/14/19
  3511. 151
    Cycloalkane derivatives
    Daiichi Sankyo
    11/14/19
  3512. 21
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    11/14/19
  3513. 485
    Intermediates for preparing triazole agonists of the APJ receptor
    Amgen
    11/14/19
  3514. 62
    Isoindoline inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    11/14/19
  3515. 10
    Pyrazolopyridyl compounds as aldosterone synthase inhibitors
    Merck Sharp & Dohme
    11/14/19
  3516. 27
    SHP2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using SHP2 inhibitors
    Indiana University Research And Technology
    11/14/19
  3517. 47
    Substituted 2-azabicycles and their use as orexin receptor modulators
    TBA
    11/14/19
  3518. 43
    Substituted tetrahydrocarbazole and carbazole carboxamide compounds
    Bristol-Myers Squibb
    11/14/19
  3519. 207
    Therapeutically active compositions and their methods of use
    Agios Pharmaceuticals
    11/14/19
  3520. 13
    Tricyclic heterocycles as BET protein inhibitors
    Incyte
    11/14/19
  3521. 10
    Heterocyclic compounds and uses thereof
    Incyte
    10/31/19
  3522. 121
    Morpholin-pyridine derivatives
    Hoffmann-La Roche
    10/31/19
  3523. 18
    N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
    Oged
    10/31/19
  3524. 32
    Substituted quinazolin-4-one derivatives
    Novartis
    10/31/19
  3525. 41
    BTK inhibitors
    Merck Sharp & Dohme
    10/28/19
  3526. 125
    Benzylamine derivatives
    Kalvista Pharmceuticals
    10/28/19
  3527. 12
    Indazoles and use thereof
    Purdue Pharma
    10/28/19
  3528. 14
    Piperidinone carboxamide azaindane CGRP receptor antagonists
    Merck Sharp & Dohme
    10/28/19
  3529. 129
    Pyridazine compounds as JAK inhibitors
    Portola Pharmaceuticals
    10/28/19
  3530. 109
    Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
    Arrien Pharmaceuticals
    10/28/19
  3531. 209
    Substituted quinolines as PDE-10 inhibitors
    Sunovion Pharmaceuticals
    10/28/19
  3532. 13
    Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
    Vtv Therapeutics
    10/28/19
  3533. 29
    Tricyclic heterocycles as bet protein inhibitors
    Incyte
    10/28/19
  3534. 19
    3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    10/27/19
  3535. 64
    Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    10/27/19
  3536. 159
    Chemical compounds
    Astrazeneca
    10/27/19
  3537. 248
    Inhibiting the transient receptor potential A1 ion channel
    Hydra Biosciences
    10/27/19
  3538. 492
    Metallo-beta-lactamase inhibitors
    Merck Sharp & Dohme
    10/27/19
  3539. 22
    N-(phenylsulfonyl)benzamides and related compounds as BCL-2 inhibitors
    The Regents Of The University Of Michigan
    10/27/19
  3540. 147
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    10/27/19
  3541. 82
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme
    10/27/19
  3542. 44
    Pyridine compounds
    Daiichi Sankyo
    10/27/19
  3543. 25
    Pyridinecarboxamides as CXCR2 modulators
    Syntrix Biosystems
    10/27/19
  3544. 42
    Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1
    Vanderbilt University
    10/27/19
  3545. 64
    Oxazole orexin receptor antagonists
    Merck Sharp & Dohme
    10/24/19
  3546. 92
    Alkyne compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    10/22/19
  3547. 10
    Benzimidazole derivatives and use thereof
    Purdue Pharma
    10/22/19
  3548. 224
    Biphenyl derivatives and methods for preparing same
    Dong-A St
    10/22/19
  3549. 166
    Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharpe & Dohme
    10/22/19
  3550. 69
    Kinase inhibitors and methods of use
    Intellikine
    10/22/19
  3551. 47
    Substituted pyrazino[2,2-a]isoquinoline derivatives
    Hoffmann-La Roche
    10/22/19
  3552. 88
    Substituted pyrazolopyrimidines and method of use
    Abbvie Deutschland
    10/22/19
  3553. 56
    (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
    Oryzon Genomics
    10/20/19
  3554. 19
    2-heteroaryl carboxamides
    Bayer Intellectual Property
    10/20/19
  3555. 14
    5-(N-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    10/20/19
  3556. 11
    Amantadine nitrate compounds with neural protective effect, and preparation and medical use thereof
    TBA
    10/20/19
  3557. 18
    Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
    Bayer Pharma Aktiengesellschaft
    10/20/19
  3558. 18
    Amino-substituted heterocyclic derivatives as sodium channel inhibitors
    Almirall
    10/20/19
  3559. 76
    Amlexanox analogs
    The Regents Of The University Of Michigan
    10/20/19
  3560. 85
    Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
    Incyte
    10/20/19
  3561. 774
    Bicyclic heteroaryl amine compounds
    Bristol-Myers Squibb
    10/20/19
  3562. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    10/20/19
  3563. 174
    Btk inhibitors
    Merck Sharp & Dohme
    10/20/19
  3564. 137
    Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
    Reset Therapeutics
    10/20/19
  3565. 97
    Compositions and methods for treating ocular diseases
    Aerpio Therapeutics
    10/20/19
  3566. 9
    Compounds and methods for inhibiting production of trimethylamine
    The Procter & Gamble
    10/20/19
  3567. 9
    Compounds, compositions and methods useful for cholesterol mobilization
    Cerenis Therapeutics Holding
    10/20/19
  3568. 94
    Dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb
    10/20/19
  3569. 227
    Factor XIA inhibitors
    Merck Sharp & Dohme
    10/20/19
  3570. 238
    Heterocyclic inhibitors of MCT4
    Vettore
    10/20/19
  3571. 16
    Hydroxmethyl piperidine orexin receptor antagonists
    Merck Sharp & Dohme
    10/20/19
  3572. 154
    Imidazopyridazine and imidazothiadiazole compounds
    Universite De Montreal
    10/20/19
  3573. 13
    Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments
    University Of California
    10/20/19
  3574. 288
    Inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    10/20/19
  3575. 92
    Inhibitors of lysine methyl transferase
    Bristol-Myers Squibb
    10/20/19
  3576. 94
    Inhibitors of plasma kallikrein
    Kalvista Pharmaceuticals
    10/20/19
  3577. 4
    Metalloenzyme inhibitor compounds
    Mycovia Pharmaceuticals
    10/20/19
  3578. 88
    Method of treating conditions with kinase inhibitors
    Allergan
    10/20/19
  3579. 7
    N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
    Ogeda
    10/20/19
  3580. 10
    Pharmaceutical formulations comprising CCR3 antagonists
    Alkahest
    10/20/19
  3581. 327
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    10/20/19
  3582. 32
    Protein kinase inhibitors
    Pharmascience
    10/20/19
  3583. 6
    Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    10/20/19
  3584. 6
    Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    10/20/19
  3585. 3
    Quinazolines as potassium ion channel inhibitors
    Bristol-Myers Squibb
    10/20/19
  3586. 370
    Solid dispersions containing an apoptosis-inducing agent
    Abbvie
    10/20/19
  3587. 44
    Substituted 2-phenyl (AZA)benzofuran compounds for the treatment of hepatitis C
    Bristol-Myers Squibb
    10/20/19
  3588. 11
    Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
    University Of Chicago
    10/20/19
  3589. 107
    Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
    Incyte
    10/20/19
  3590. 143
    Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
    Bayer Pharma Aktiengesellschaft
    10/20/19
  3591. 118
    Substituted pyrazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    10/20/19
  3592. 9
    Substituted pyrazoles as inhibitors of fibroblast growth factor receptor
    Zhejiang Hisun Pharmaceutical
    10/20/19
  3593. 411
    Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
    Lycera
    10/20/19
  3594. 507
    Triazole agonists of the APJ receptor
    Amgen
    10/20/19
  3595. 65
    Triazolopyridine inhibitors of myeloperoxidase
    Bristol-Myers Squibb
    10/20/19
  3596. 57
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    Max-DelbrÜCk-Centrum FÜR Molekulare Medizin
    10/20/19
  3597. 255
    Compounds, compositions and methods
    Denali Therapeutics
    10/14/19
  3598. 33
    Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
    Merck Patent
    10/14/19
  3599. 24
    Protein kinase inhibitor containing pyrrolopyridazine derivative
    The Asan Foundation
    10/14/19
  3600. 126
    Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
    Novartis
    10/14/19
  3601. 12
    Selective glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    10/14/19
  3602. 227
    TrkA kinase inhibitors, compositions and methods thereof
    Merck Sharp & Dohme
    10/14/19
  3603. 92
    Azabenzimidazole compounds
    Pfizer
    10/13/19
  3604. 23
    Chemically modified quinoline and quinolone derivatives useful as CB-1 inverse agonists
    Janssen Pharmaceutica
    10/13/19
  3605. 76
    Complement pathway modulators and uses thereof
    Novartis
    10/13/19
  3606. 7
    Liver X receptor modulators
    Vitae Pharamceuticals
    10/13/19
  3607. 689
    Pyrimidone carboxamide compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    10/13/19
  3608. 91
    Quinolone derivatives as fibroblast growth factor receptor inhibitors
    Principia Biopharma
    10/13/19
  3609. 7
    Rho kinase inhibitors
    Kadmon
    10/13/19
  3610. 166
    Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors
    The University Of Rochester
    10/13/19
  3611. 24
    Aminoester derivatives
    Chiesi Farmaceutici
    10/07/19
  3612. 7
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme
    10/07/19
  3613. 1
    Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
    Suzhou Zelgen Biopharmaceuticals
    10/07/19
  3614. 30
    Factor IXa inhibitors
    Merck Sharp & Dohme
    10/07/19
  3615. 25
    Factor XIa inhibitors
    Merck Sharp & Dohme
    10/07/19
  3616. 248
    Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
    Les Laboratoires Servier
    10/07/19
  3617. 31
    Oxazolidine-based compound and selective androgen receptor agonist comprising same
    Dong-A St
    10/07/19
  3618. 422
    Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
    Merck Sharp & Dohme
    10/07/19
  3619. 44
    2-aryl selenazole compound and pharmaceutical composition thereof
    Jiangsu Atom Bioscience And Pharmaceutical
    10/01/19
  3620. 9
    3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II
    GrÜNenthal
    10/01/19
  3621. 43
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University Of The Commonwealth System Of Higher Education
    10/01/19
  3622. 34
    Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffmann-La Roche
    10/01/19
  3623. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    10/01/19
  3624. 24
    C-6 spirocarbocyclic iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    10/01/19
  3625. 476
    Heteroaryls and uses thereof
    Millennium Pharmaceuticals
    10/01/19
  3626. 23
    Imidazopyridazine derivatives as modulators of the GABAA receptor activity
    Pfizer
    10/01/19
  3627. 215
    Indole carboxamide compounds
    Bristol-Myers Squibb
    10/01/19
  3628. 20
    Inhibitors of bruton's tyrosine kinase
    Hoffman-La Roche
    10/01/19
  3629. 62
    Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    10/01/19
  3630. 77
    Macrocycles as factor XIa inhibitors
    Bristol-Myers Squibb
    10/01/19
  3631. 107
    Pyridineamine compounds useful as Pim kinase inhibitors
    Incyte
    10/01/19
  3632. 34
    Pyridinyl and fused pyridinyl triazolone derivatives
    Takeda Pharmaceutical
    10/01/19
  3633. 129
    Pyrimidine compounds as mTOR and PI3K inhibitors
    Development Center For Biotechnology
    10/01/19
  3634. 32
    Quinoline derivatives as PDE10A enzyme inhibitors
    H. Lundbeck
    10/01/19
  3635. 219
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    Galapagos
    09/24/19
  3636. 167
    Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    09/23/19
  3637. 11
    Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
    Biomarin Pharmaceutical
    09/23/19
  3638. 33
    Compounds as diacylglycerol acyltransferase inhibitors
    Glaxosmithkline
    09/23/19
  3639. 44
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    09/23/19
  3640. 23
    Dihydroquinoline pyrazolyl compounds
    Hoffmann-La Roche
    09/23/19
  3641. 344
    ERK inhibitors and uses thereof
    Celgene Car
    09/23/19
  3642. 31
    Glucocerebrosidase modulators and uses thereof
    Alectos Therapeutics
    09/23/19
  3643. 31
    Imidazole-derived modulators of the glucocorticoid receptor
    Bristol-Myers Squibb
    09/23/19
  3644. 173
    Inhibitors of Jun N-terminal kinase
    Imago Pharmaceuticals
    09/23/19
  3645. 93
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics
    09/23/19
  3646. 61
    Kinase inhibitors
    Respivert
    09/23/19
  3647. 59
    Method of treatment using substituted imidazo[1,2b]pyridazine compounds
    Array Biopharma
    09/23/19
  3648. 60
    Method of treatment using substituted imidazo[1,2b]pyridazine compounds
    Array Biopharma
    09/23/19
  3649. 36
    Piperazine derivatives for treating disorders
    The University Of Nottingham
    09/23/19
  3650. 9
    Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
    Gilead Sciences
    09/23/19
  3651. 15
    Protein kinase inhibitors
    Pharmascience
    09/23/19
  3652. 122
    Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
    Millennium Pharmaceuticals
    09/23/19
  3653. 42
    Pyridopyrimidine or pyrimidopyrimidine compound, prepration method, pharmaceutical composition, and use thereof
    Shandong Luoxin Pharmaceutical Group Stock
    09/23/19
  3654. 1352
    Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors
    Abbvie
    09/23/19
  3655. 35
    Pyrrolopyrimidine compounds for the treatment of cancer
    University Of North Carolina At Chapel Hill
    09/23/19
  3656. 18
    S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7
    Consejo Superior De Investigaciones Cientificas
    09/23/19
  3657. 124
    Selective inhibitors of Tec and Src protein kinase families
    Pharmascience
    09/23/19
  3658. 232
    Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array Biopharma
    09/23/19
  3659. 275
    Substituted quinazolines as receptor-type kinase inhibitors
    Symphony Evolution
    09/23/19
  3660. 23
    1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
    Takeda Pharmaceutical
    09/21/19
  3661. 83
    2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
    Array Biopharma
    09/21/19
  3662. 3
    ACC inhibitors and uses thereof
    Gilead Apollo
    09/21/19
  3663. 25
    Benzothiophene estrogen receptor modulators
    G1 Therapeutics
    09/21/19
  3664. 133
    Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
    Enanta Pharmaceuticals
    09/21/19
  3665. 322
    Compounds useful for the treatment of degenerative and inflammatory diseases
    Galapagos
    09/21/19
  3666. 97
    Condensed tricyclic compounds as protein kinase inhibitors
    FundaciÓN Del Sector PÚBlico Estatal Centro Nacional De Investigaciones OncolÓGicas Carlos Iii (F.S.P. Cnio
    09/21/19
  3667. 19
    Eis inhibitors
    University Of Kentucky Research Foundation
    09/21/19
  3668. 11
    Fused imidazo-piperidine JAK inhibitors
    Theravance Biopharma R&D Ip
    09/21/19
  3669. 246
    GLP-1 receptor agonists and uses thereof
    Pfizer
    09/21/19
  3670. 7
    Heterocyclic inhibitors of the sodium channel
    TBA
    09/21/19
  3671. 68
    Imidazopyridazine compounds and their use
    Hutchison Medipharma
    09/21/19
  3672. 10
    Inhibitors of HIF prolyl hydroxylase
    Merck Sharp & Dohme
    09/21/19
  3673. 119
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    09/21/19
  3674. 36
    Inhibitors of the renal outer medullary potassium channel
    Wuxi Apptec (Shanghai)
    09/21/19
  3675. 93
    Isoindoline compositions and methods for treating neurodegenerative disease
    Cognition Therapeutics
    09/21/19
  3676. 46
    Macrocycles as factor XIa inhibitors
    Bristol-Myers Squibb
    09/21/19
  3677. 31
    Methods for inhibiting fascin
    Cornell University
    09/21/19
  3678. 1
    Processes for preparing ATR inhibitors
    Vertex Pharmaceuticals
    09/21/19
  3679. 62
    Substituted amino triazoles useful as human chitinase inhibitors
    Oncoarendi Therapeutics
    09/21/19
  3680. 21
    Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
    Bristol-Myers Squibb
    09/21/19
  3681. 35
    Tertiary alcohol imidazopyrazine BTK inhibitors
    Merck Sharp & Dohme
    09/21/19
  3682. 311
    Therapeutic compounds and uses thereof
    Genentech
    09/21/19
  3683. 187
    Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases
    Allergan
    09/21/19
  3684. 21
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte Holdings
    09/09/19
  3685. 106
    2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives
    Hoffmann-La Roche
    09/09/19
  3686. 356
    Bruton's tyrosine kinase inhibitors
    Sunesis Pharmaceuticals
    09/09/19
  3687. 19
    Compositions and methods of modulating 15-PGDH activity
    Case Western Reserve University
    09/09/19
  3688. 91
    Compositions and methods of modulating short-chain dehydrogenase activity
    Case Western Reserve University
    09/09/19
  3689. 45
    Compounds as rearranged during transfection (RET) inhibitors
    Glaxosmithkline
    09/09/19
  3690. 55
    Diacylglycerol acyltransferase 2 inhibitors
    Pfizer
    09/09/19
  3691. 72
    Enhancer of zeste homolog 2 inhibitors
    Glaxosmithkline
    09/09/19
  3692. 287
    Heteroaryl compounds as IRAK inhibitors and uses thereof
    Merck Patent
    09/09/19
  3693. 194
    Heterocyclic kinase inhibitors
    Intellikine
    09/09/19
  3694. 25
    Inhibitor compounds of phosphodiesterase type 10A
    Abbvie
    09/09/19
  3695. 118
    Kinase inhibitors
    Respivert
    09/09/19
  3696. 17
    Kinase inhibitors
    Respivert
    09/09/19
  3697. 4
    Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae
    Oryzon Genomics
    09/09/19
  3698. 130
    MK2 inhibitors and uses thereof
    Celgene Car
    09/09/19
  3699. 10
    Methods of identifying SENP1 inhibitors
    City Of Hope
    09/09/19
  3700. 113
    Piperidine and azepine derivatives as prokineticin receptor modulators
    Takeda Pharmaceutical
    09/09/19
  3701. 41
    Piperidine derivatives as HDAC1/2 inhibitors
    Regenacy Pharmaceuticals
    09/09/19
  3702. 85
    Pyridinyloxy- and phenyloxy-pyrazolyl compounds
    Hoffmann-La Roche
    09/09/19
  3703. 20
    Somatostatin receptor subtype 4 (SSTR4) agonists
    Centrexion Therapeutics
    09/09/19
  3704. 98
    Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
    Janssen Pharmaceutica
    09/09/19
  3705. 25
    Substituted cyclopentanes, tetrahydrofuranes and pyrrolidines as orexin receptor antagonists
    Takeda Pharmaceutical
    09/09/19
  3706. 12
    Substituted tropolone derivatives and methods of use
    University Of Connecticut
    09/09/19
  3707. 16
    β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
    Atea Pharmaceuticals
    09/02/19
  3708. 393
    1,3-thiazol-2-yl substituted benzamides
    Bayer Aktiengesellschaft
    09/02/19
  3709. 39
    2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
    Blueprint Medicines
    09/02/19
  3710. 15
    3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
    Idenix Pharmaceuticals
    09/02/19
  3711. 115
    3-(1H-benzo[D]imidazol-2-yl)-1H-pyrazolo[3,4-C]pyridine and therapeutic uses thereof
    Samumed
    09/02/19
  3712. 46
    8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
    Boehringer Ingelheim International
    09/02/19
  3713. 153
    Benzimidazole derivatives as selective proteine kinase inhibitors
    Ab Science
    09/02/19
  3714. 88
    CXCR7 receptor modulators
    Idorsia Pharmaceuticals
    09/02/19
  3715. 34
    Dihydroxy aromatic heterocyclic compound
    Takeda Pharmaceutical
    09/02/19
  3716. 43
    Fused-ring compounds, pharmaceutical composition and uses thereof
    Shanghai De Novo Pharmatech
    09/02/19
  3717. 28
    Heteroaryl substituted aminopyridine compounds
    Bristol-Myers Squibb
    09/02/19
  3718. 49
    Heteroaryls and uses thereof
    Millennium Pharmaceuticals
    09/02/19
  3719. 62
    Heterocyclic compounds and methods of use thereof
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    09/02/19
  3720. 145
    Histone demethylase inhibitors
    Celgene Quanticel Research
    09/02/19
  3721. 20
    Hydroxy-ethylene derivatives for the treatment of arthrosis
    Merck Patent
    09/02/19
  3722. 2
    Inhibitors of leukotriene A4 hydrolase
    Celtaxsys
    09/02/19
  3723. 81
    MCT4 inhibitors for treating disease
    Vettore
    09/02/19
  3724. 18
    Macrocyclic benzofuran compounds for the treatment of hepatitis C
    Bristol-Myers Squibb
    09/02/19
  3725. 26
    N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors
    Redx Pharma
    09/02/19
  3726. 19
    Oxazolidin-2-one-pyrimidine derivatives and the use thereof as phosphatidylinositol-3-kinase inhibitors
    Novartis
    09/02/19
  3727. 127
    Polycyclic pyridone derivative having integrase inhibitory activity
    Shionogi
    09/02/19
  3728. 120
    Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
    Millennium Pharmaceuticals
    09/02/19
  3729. 388
    Substituted polycyclic carbamoyl pyridone derivative prodrug
    Shionogi
    09/02/19
  3730. 361
    Therapeutic compounds
    Celgene Quanticel Research
    09/02/19
  3731. 120
    Therapeutic compounds and uses thereof
    Genentech
    09/02/19
  3732. 200
    Therapeutic compounds and uses thereof
    Genentech
    09/02/19
  3733. 107
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    08/20/19
  3734. 80
    Substituted quinolines as modulators of sodium channels
    Vertex Pharmaceuticals
    08/20/19
  3735. 19
    Aminoimidazopyridazines
    Bayer Pharma Aktiengesellschaft
    08/19/19
  3736. 40
    Factor Xla inhibitors
    Merck Sharp & Dohme
    08/19/19
  3737. 66
    IAP antagonists
    Bristol-Myers Squibb
    08/19/19
  3738. 356
    Indazole ureas and method of use
    Abbvie
    08/19/19
  3739. 22
    Kinase inhibitors
    Respivert
    08/19/19
  3740. 10
    Protein tyrosine kinase modulators and methods of use
    Betta Pharmaceuticals
    08/19/19
  3741. 9
    Pyranochromenyl phenol derivative, and pharmaceutical composition for treating metabolic syndrome or inflammatory disease
    Glaceum
    08/19/19
  3742. 255
    Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease
    Lycera
    08/18/19
  3743. 18
    2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
    Northwestern University
    08/17/19
  3744. 24
    Quinoline derivatives and their applications
    Shenyang Pharmaceutical University
    08/17/19
  3745. 232
    Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array Biopharma
    08/17/19
  3746. 33
    Amino-substituted imidazopyridazines
    Bayer Intellectual Property
    08/13/19
  3747. 185
    Furo-3-carboxamide derivatives and methods of use
    Abbvie
    08/13/19
  3748. 306
    PRMT5 inhibitors and uses thereof
    Epizyme
    08/13/19
  3749. 111
    Substituted 4-phenylpiperidines, their preparation and use
    Columbia University
    08/13/19
  3750. 90
    Tricyclic fused thiophene derivatives as JAK inhibitors
    Incyte Holdings
    08/13/19
  3751. 366
    Bicyclic sulfonamide compounds as sodium channel inhibitors
    Amgen
    08/12/19
  3752. 73
    Isoindolone derivatives
    Abbvie
    08/12/19
  3753. 158
    Pyrazole derivative
    Mochida Pharmaceutical
    08/12/19
  3754. 206
    Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
    Sanofi
    08/12/19
  3755. 269
    Tricyclic heterocycles as bet protein inhibitors
    Incyte
    08/12/19
  3756. 41
    2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
    Merck Sharp & Dohme
    08/11/19
  3757. 109
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    08/11/19
  3758. 119
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    08/11/19
  3759. 8
    Pyrazolylbenzo[d]imidazole derivatives
    Celon Pharma
    08/11/19
  3760. 253
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    08/06/19
  3761. 156
    Indazole compounds useful as ketohexokinase inhibitors
    Janssen Pharmaceutica
    08/06/19
  3762. 14
    Kinase inhibitors based upon N-alkyl pyrazoles
    Topivert Pharma
    08/06/19
  3763. 28
    N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
    Pfizer
    08/06/19
  3764. 51
    N-substituted benzamides and methods of use thereof
    Genentech
    08/06/19
  3765. 33
    Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II
    Medifron Dbt
    08/06/19
  3766. 20
    Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors
    Phoenix Molecular Design
    08/06/19
  3767. 293
    Carbocyclic sulfone RORγ modulators
    Bristol-Myers Squibb
    08/05/19
  3768. 119
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    08/05/19
  3769. 17
    Phenoxyalkylamine compound
    Osaka University
    08/02/19
  3770. 308
    Therapeutic compounds and uses thereof
    Genentech
    07/30/19
  3771. 14
    3-ester-4 substituted orexin receptor antagonists
    Merck Sharp & Dohme
    07/29/19
  3772. 136
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
    University Of Washington Through Its Center For Commercialization
    07/29/19
  3773. 23
    Heteroaryl compounds and uses thereof
    Celgene Car
    07/29/19
  3774. 74
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    07/29/19
  3775. 173
    Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Les Laboratoires Servier
    07/29/19
  3776. 193
    PRMT5 inhibitors and uses thereof
    Epizyme
    07/29/19
  3777. 113
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    07/29/19
  3778. 37
    Pyridine compounds as sodium channel blockers
    Purdue Pharma
    07/29/19
  3779. 19
    Substituted benzylpyrazoles
    Bayer Pharma Aktiengesellschaft
    07/29/19
  3780. 39
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    07/29/19
  3781. 15
    Therapeutic agent for pain
    Astellas Pharma
    07/29/19
  3782. 442
    Tricyclic piperidine compounds
    Actelion Pharmaceuticals
    07/29/19
  3783. 201
    Autotaxin inhibitors
    Novartis
    07/26/19
  3784. 262
    Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
    Novartis
    07/26/19
  3785. 65
    IDO inhibitors
    Bristol-Myers Squibb
    07/26/19
  3786. 43
    Trk-inhibiting compound
    Ono Pharmaceutical
    07/26/19
  3787. 44
    1-(cycloalkyl-carbonyl)proline derivative
    Sumitomo Dainippon Pharma
    07/22/19
  3788. 11
    2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
    Crystalgenomics
    07/22/19
  3789. 35
    3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use
    Iteos Therapeutics
    07/22/19
  3790. 132
    4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
    Merck Sharp & Dohme
    07/22/19
  3791. 67
    Aryl substituted indoles and the use thereof
    Purdue Pharma
    07/22/19
  3792. 95
    Benzimidazole derivatives: preparation and pharmaceutical applications
    Mei Pharma
    07/22/19
  3793. 116
    Compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    07/22/19
  3794. 15
    Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities
    Almirall
    07/22/19
  3795. 17
    Glucosylceramide synthase inhibitors and therapeutic methods using the same
    The Regents Of The University Of Michigan
    07/22/19
  3796. 7
    Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
    Amgen
    07/22/19
  3797. 27
    Heterocyclic GSK-3 allosteric modulators
    Consejo Superior De Investigaciones Cientificas (Csic
    07/22/19
  3798. 21
    Histone demethylase inhibitors
    Celgene Quanticel Research
    07/22/19
  3799. 18
    Lysine specific demethylase-1 inhibitors and their use
    Oryzon Genomics
    07/22/19
  3800. 71
    Naphthyridine derivative compounds
    Astex Therapeutics
    07/22/19
  3801. 159
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    07/22/19
  3802. 153
    Pyrimidine derivatives
    Pfizer
    07/22/19
  3803. 362
    Quinolinyl modulators of RORγt
    Janssen Pharmaceutica
    07/22/19
  3804. 102
    Styrenyl derivative compounds for treating ophthalmic diseases and disorders
    Acucela
    07/22/19
  3805. 350
    Therapeutic compounds and compositions
    Agios Pharmaceuticals
    07/22/19
  3806. 20
    Triazolopyridines and triazolopyrazines as LSD1 inhibitors
    Incyte
    07/22/19
  3807. 10
    4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE)
    Janssen Pharmaceutica
    07/11/19
  3808. 138
    Aryl sultam derivatives as RORc modulators
    Genentech
    07/11/19
  3809. 224
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    07/11/19
  3810. 6
    Ethynyl derivatives
    Hoffmann-La Roche
    07/11/19
  3811. 477
    Heteroaryls and uses thereof
    Millennium Pharmaceuticals
    07/11/19
  3812. 58
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals
    07/11/19
  3813. 115
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    07/11/19
  3814. 4
    Kinase inhibitors
    Respivert
    07/11/19
  3815. 47
    Macrocyclic compounds as Trk kinase inhibitors
    Array Biopharma
    07/11/19
  3816. 14
    Pyridazinones as DAAO enzyme inhibitors
    Takeda Pharmaceutical
    07/11/19
  3817. 21
    Selective histone deactylase 6 inhibitors
    H. Lee Moffitt Cancer Center And Research Institute
    07/11/19
  3818. 148
    Substituted uracils and use thereof
    Bayer Pharma Aktiengesellschaft
    07/11/19
  3819. 11
    TRPA1 antagonists
    Abbvie
    07/11/19
  3820. 114
    2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
    Pfizer
    07/05/19
  3821. 59
    2-pyridyloxy-4-ether orexin receptor antagonists
    Merck Sharp & Dohme
    07/05/19
  3822. 126
    4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    07/05/19
  3823. 62
    Aldosterone synthase inhibitors
    Boehringer Ingelheim International
    07/05/19
  3824. 32
    Amidoimidazopyridazines as MKNK-1 kinase inhibitors
    Bayer Pharma Aktiengesellschaft
    07/05/19
  3825. 20
    Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
    Piramal Imaging
    07/05/19
  3826. 45
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    07/05/19
  3827. 885
    Flap modulators
    Janssen Pharmaceutica
    07/05/19
  3828. 140
    Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
    Shanghai Yingli Pharmaceutical
    07/05/19
  3829. 23
    Heterocyclic compounds and their use as dopamine D1 ligands
    Pfizer
    07/05/19
  3830. 198
    Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
    Sk Biopharmaceuticals
    07/05/19
  3831. 44
    Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    07/05/19
  3832. 47
    Indoline compounds as aldosterone synthase inhibitors
    Merck Sharp & Dohme
    07/05/19
  3833. 90
    Kallikrein 7 inhibitors
    Sixera Pharma
    07/05/19
  3834. 274
    PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
    Epizyme
    07/05/19
  3835. 286
    Pyrazolopyrimidine compounds for the treatment of cancer
    University Of North Carolina At Chapel Hill
    07/05/19
  3836. 22
    Pyrimidines and use thereof
    Purdue Pharma
    07/05/19
  3837. 89
    Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
    Incyte
    07/05/19
  3838. 169
    Uracil derivatives as AXL and c-MET kinase inhibitors
    Ignyta
    07/05/19
  3839. 7
    Antagonists of prostaglandin EP3 receptor
    Pfizer
    07/01/19
  3840. 18
    Bicyclic heterocycles as bet protein inhibitors
    Incyte
    07/01/19
  3841. 10
    Bicyclic inhibitors
    Kalvista Pharmaceuticals
    07/01/19
  3842. 24
    Compounds
    Astex Therapeutics
    07/01/19
  3843. 36
    Compounds as diacylglycerol acyltransferase inhibitors
    Glaxosmithkline
    07/01/19
  3844. 93
    Histone demethylase inhibitors
    Celgene Quantical Research
    07/01/19
  3845. 16
    Inhibitors of lysine methyl transferase
    Bristol-Myers Squibb
    07/01/19
  3846. 17
    NMDA receptor modulators and uses related thereto
    Emory University
    07/01/19
  3847. 18
    Phenyl and benzodioxinyl substituted indazoles derivatives
    Astrazeneca
    07/01/19
  3848. 9
    Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
    University Of Kansas
    07/01/19
  3849. 111
    Pyrrolotriazine kinase inhibitors
    Bristol-Myers Squibb
    07/01/19
  3850. 7
    Selected macrolides with PDE4-inhibiting activity
    Basilea Pharmaceutica
    07/01/19
  3851. 17
    Small molecule activators of NRF2 pathway
    The General Hospital
    07/01/19
  3852. 21
    Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions
    University Of Utah Research Foundation
    07/01/19
  3853. 8
    Substituted benzamide derivatives as in vitro MAO-B inhibitors
    Ntz Lab
    07/01/19
  3854. 379
    Tetrahydro-pyrimidoazepines as modulators of TRPV1
    Janssen Pharmaceutica
    07/01/19
  3855. 318
    Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors
    Bristol-Myers Squibb
    07/01/19
  3856. 33
    Substituted aminoimidazopyridazines
    Bayer Intellectual Property
    06/26/19
  3857. 43
    Ether compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    06/24/19
  3858. 21
    2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
    Northwestern University
    06/23/19
  3859. 555
    Aminotriazine derivative and pharmaceutical composition comprising the same
    Shionogi
    06/23/19
  3860. 326
    Arylquinazolines
    Merck Patent
    06/23/19
  3861. 990
    Benzimidazole-proline derivatives
    Idorsia Pharmaceuticals
    06/23/19
  3862. 39
    C2-carbocyclic iminothiazine dioxides as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    06/23/19
  3863. 16
    Carbamate, ester, and ketone compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    06/23/19
  3864. 38
    Cinnoline derivatives useful as CB-1 receptor inverse agonists
    Janssen Pharmaceutica
    06/23/19
  3865. 30
    Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor
    Janssen Pharmaceutica
    06/23/19
  3866. 353
    FLAP modulators
    Janssen Pharmaceutica
    06/23/19
  3867. 237
    Heterocyclic derivative and pharmaceutical drug
    Nippon Shinyaku
    06/23/19
  3868. 326
    Heterocyclylamines as PI3K inhibitors
    Incyte Holdings
    06/23/19
  3869. 72
    Kinase inhibitors
    Respivert
    06/23/19
  3870. 8
    N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides and their pharmaceutical and cosmetic use
    Galderma Research & Development
    06/23/19
  3871. 29
    PRMT5 inhibitors and uses thereof
    Epizyme
    06/23/19
  3872. 26
    Process for the synthesis of a phosphoinositide 3-kinase inhibitor
    Incyte
    06/23/19
  3873. 370
    Purine inhibitors of human phosphatidylinositol 3-kinase delta
    Merck Sharp & Dohme
    06/23/19
  3874. 33
    Pyridinone and pyrimidinone derivatives as factor Xia
    Ono Pharmaceutical
    06/23/19
  3875. 67
    Pyrimidine FGFR4 inhibitors
    Eisai R&D Management
    06/23/19
  3876. 11
    Quinazoline derivatives substituted by aniline, preparation method and use thereof
    Xuanzhu Pharma
    06/23/19
  3877. 377
    RAF kinase modulator compounds and methods of use thereof
    Ambit Biosciences
    06/23/19
  3878. 23
    Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]OXAZEPINES and methods for treating viral infections
    Gilead Sciences
    06/23/19
  3879. 87
    Carbazole compounds useful as bromodomain inhibitors
    Bristol-Myers Squibb
    06/16/19
  3880. 174
    Compounds antagonizing A3 adenosine receptor, method for preparing them, and medical-use thereof
    Handok
    06/16/19
  3881. 57
    Inhibitors of the fibroblast growth factor receptor
    Blueprint Medicines
    06/16/19
  3882. 6
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D Ip
    06/16/19
  3883. 1
    MCL-1 inhibitors and methods of use thereof
    Astrazeneca
    06/16/19
  3884. 233
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi
    06/16/19
  3885. 119
    Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection
    Hoffmann-La Roche
    06/16/19
  3886. 24
    1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as SGRM modulators
    Astrazeneca
    06/14/19
  3887. 127
    4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    06/14/19
  3888. 41
    Benzimidazole-2-piperazine heterocyclic compound, pharmaceutical composition containing the same, preparation method and use thereof
    Shanghai Huilun Life Science & Technology
    06/14/19
  3889. 10
    Chemical compounds
    Glaxosmithkline
    06/14/19
  3890. 9
    Inhibitors of BCR-ABL mutants and use thereof
    The Regents Of The University Of Michigan
    06/14/19
  3891. 11
    Quinazoline derivative, preparation method therefor, and pharmaceutical composition and application thereof
    Arromax Pharmatech
    06/14/19
  3892. 102
    Spirocyclic EBI2 modulators
    Sanford Burnham Prebys Medical Discovery Institute
    06/14/19
  3893. 86
    Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein
    The Governing Council Of The University Of Toronto
    06/14/19
  3894. 4
    Substituted quinazoline compounds and preparation and uses thereof
    Sunshine Lake Pharma
    06/14/19
  3895. 3
    Tetrahydropyranyl benzamide derivatives
    Eli Lilly
    06/14/19
  3896. 6
    bis-Pyridazine compounds and their use in treating cancer
    Astrazeneca
    06/14/19
  3897. 32
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors
    Respivert
    06/12/19
  3898. 89
    3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I
    Grunenthal
    06/12/19
  3899. 15
    7-azaindole derivatives
    Merck Patent
    06/12/19
  3900. 201
    Biaryl acetamide compounds and methods of use thereof
    Ambit Biosciences
    06/12/19
  3901. 45
    CDK inhibitors
    G1 Therapeutics
    06/12/19
  3902. 38
    Carboxamide derivatives
    Novartis
    06/12/19
  3903. 146
    Compounds as tyrosine kinase modulators
    Allergan
    06/12/19
  3904. 15
    Conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as anti-tumor agents
    Duquesne University Of The Holy Spirit
    06/12/19
  3905. 296
    Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors
    Merck Sharp & Dohme
    06/12/19
  3906. 44
    Cystathionine-γ-lyase (CSE) inhibitors
    Sova Pharmaceuticals
    06/12/19
  3907. 17
    Cytochrome P450 inhibitors and their method of use
    Cortendo Ab (Publ
    06/12/19
  3908. 91
    Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
    Nektar Therapeutics
    06/12/19
  3909. 98
    GPR40 agonists in anti-diabetic drug combinations
    Janssen Pharmaceutica
    06/12/19
  3910. 32
    Heteroaryl-pyrimidinone compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    06/12/19
  3911. 338
    Heterocyclic derivative having PGD2 receptor antagonist activity
    Shionogi
    06/12/19
  3912. 99
    Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders
    The University Of Mississippi
    06/12/19
  3913. 31
    Hydroxy-substituted orexin receptor antagonists
    Merck Sharp & Dohme
    06/12/19
  3914. 3
    Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
    Deuterx
    06/12/19
  3915. 49
    N-substituted-5-substituted phthalamic acids as sortilin inhibitors
    H. Lundbeck
    06/12/19
  3916. 5
    Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
    Dartmouth College
    06/12/19
  3917. 7
    Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    06/12/19
  3918. 20
    Quinazoline derivative and preparation method therefor
    Chia Tai Tianqing Pharmaceutical Group
    06/12/19
  3919. 31
    RORγ modulators
    Bristol-Myers Squibb
    06/12/19
  3920. 16
    Substituted 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines as factor XIa inhibitors
    Bristol-Myers Squibb
    06/12/19
  3921. 26
    Substituted acethydrazide derivative, preparation method and use thereof
    Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China
    06/12/19
  3922. 343
    Substituted pyrimidine compounds
    Gruenenthal
    06/12/19
  3923. 292
    Tricyclic compounds as anticancer agents
    Bristol-Myers Squibb
    06/12/19
  3924. 12
    Use of small molecule inhibitors targeting EYA tyrosine phosphatase
    Cincinnati Childrens Hospital Medical Center
    06/12/19
  3925. 9
    [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof
    Santen Pharmaceutical
    06/12/19
  3926. 6
    γ-aminobutyric acid (GABA) analogues for the treatment of pain and other disorders
    Novassay
    06/04/19
  3927. 28
    2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin D inhibitors
    Merck Patent
    06/04/19
  3928. 573
    2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease
    Lycera
    06/04/19
  3929. 40
    3-aminocycloalkyl compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    06/04/19
  3930. 18
    5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof
    Cancer Research Technology
    06/04/19
  3931. 67
    5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives
    Hoffmann-La Roche
    06/04/19
  3932. 492
    AMPK-activating heterocyclic compounds and methods for using the same
    Rigel Pharmaceuticals
    06/04/19
  3933. 113
    Aminopyrimidinyl compounds
    Pfizer
    06/04/19
  3934. 53
    Aromatic heterocyclic compounds and their application in pharmaceuticals
    Sunshine Lake Pharma
    06/04/19
  3935. 176
    Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
    Vitae Pharmaceuticals
    06/04/19
  3936. 56
    BET protein-inhibiting 5-aryltriazoleazepines
    Bayer Pharma Aktiengesellschaft
    06/04/19
  3937. 308
    Biaryl acyl-sulfonamide compounds as sodium channel inhibitors
    Amgen
    06/04/19
  3938. 33
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    06/04/19
  3939. 16
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    06/04/19
  3940. 4
    Factor XIa inhibitors
    Merck Sharp & Dohme
    06/04/19
  3941. 17
    Glycine transporter-1 inhibitors
    Amgen
    06/04/19
  3942. 9
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche
    06/04/19
  3943. 33
    Phosphonate compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    06/04/19
  3944. 119
    Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
    Millennium Pharmaceuticals
    06/04/19
  3945. 224
    Pyrimidine PDE10 inhibitors
    Merck Sharp & Dohme
    06/04/19
  3946. 292
    Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    Merck Sharp & Dohme
    06/04/19
  3947. 21
    Sphingosine 1-phosphate receptor antagonists
    Arroyo Biosciences
    06/04/19
  3948. 22
    Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections
    Gilead Sciences
    06/04/19
  3949. 28
    Substituted triazolopyridines and their use as TTK inhibitors
    Bayer Pharma Aktiengesellschaft
    06/04/19
  3950. 96
    Tricyclic pyrido-carboxamide derivatives as rock inhibitors
    Bristol-Myers Squibb
    06/04/19
  3951. 21
    3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose
    Sanwa Kagaku Kenkyusho
    06/03/19
  3952. 26
    Acetylcholinesterase inhibitors and promnesiant serotonin 5-HT4 receptor agonists, their methods of preparation and the pharmaceutical compositions containing the same
    Universite De Caen
    06/03/19
  3953. 240
    Aminopyrimidine derivatives for use as modulators of kinase activity
    Merck Patent
    06/03/19
  3954. 295
    Benzodioxane inhibitors of leukotriene production for combination therapy
    Boehringer Ingelheim International
    06/03/19
  3955. 66
    Cyclopropanecarboxylic acid derivative
    Daiichi Sankyo
    06/03/19
  3956. 393
    Phenyl and pyridinyl substituted piperidines and piperazines as inhibitors of IDH1 mutants and their use in treating cancer
    Agios Pharmaceuticals
    06/03/19
  3957. 307
    RORγ modulators
    Bristol-Myers Squibb
    06/03/19
  3958. 209
    Sulfur derivatives as chemokine receptor modulators
    Allergan
    06/03/19
  3959. 207
    4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
    Array Biopharma
    05/29/19
  3960. 55
    Aminoester derivatives
    Chiesi Farmaceutici
    05/29/19
  3961. 10
    Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
    Leo Pharma
    05/29/19
  3962. 28
    Btk inhibitors
    Merck Sharp & Dohme
    05/29/19
  3963. 20
    Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof
    Shanghai Hengrui Pharmaceutical
    05/29/19
  3964. 43
    Heteroaryl compounds as 5-HT4 receptor ligands
    Suven Life Sciences
    05/29/19
  3965. 33
    Heterocyclic compounds as inhibitors of class I PI3KS
    TBA
    05/29/19
  3966. 21
    Heterocyclic sulfone RORγ modulators
    Bristol-Myers Squibb
    05/29/19
  3967. 32
    Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors
    Hoffman-La Roche
    05/29/19
  3968. 23
    Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase
    Hoffmann-La Roche
    05/29/19
  3969. 34
    Purinone compounds as kinase inhibitors
    Pharmacyclics
    05/29/19
  3970. 538
    Purinones as ubiquitin-specific protease 1 inhibitors
    Forma Therapeutics
    05/29/19
  3971. 292
    Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    Merck Sharp & Dohme
    05/29/19
  3972. 389
    Substituted 6,5-fused bicyclic heteroaryl compounds
    Epizyme
    05/29/19
  3973. 378
    Substituted 7-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    05/29/19
  3974. 45
    Substituted pyrrolopyrimidines as HDM2 inhibitors
    Merck Sharp & Dohme
    05/29/19
  3975. 40
    Substituted tricyclic heterocyclic compounds
    Bristol-Myers Squibb
    05/29/19
  3976. 15
    Tetrahydrocarboline derivative
    Ono Pharmaceutical
    05/29/19
  3977. 114
    Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Hoffman-La Roche
    05/26/19
  3978. 21
    Derivatives and methods of treating hepatitis B infections
    Novira Therapeutics
    05/26/19
  3979. 181
    Non-nucleoside reverse transcriptase inhibitors
    Merck Sharp & Dohme
    05/26/19
  3980. 189
    Therapeutic compounds, compositions and methods of use thereof
    Genentech
    05/26/19
  3981. 171
    Alkoxy compounds for disease treatment
    Acucela
    05/25/19
  3982. 55
    Diacylglycerol acyltransferase 2 inhibitors
    Pfizer
    05/25/19
  3983. 86
    Factor IXa inhibitors
    Merck Sharp & Dohme
    05/25/19
  3984. 192
    Heteroaryl compounds and uses thereof
    Celgene Car
    05/25/19
  3985. 27
    Imaging histone deacetylases with a radiotracer using positron emission tomography
    The General Hospital
    05/25/19
  3986. 139
    Inhibiting agents for Bruton's tyrosine kinase
    Biogen Ma
    05/25/19
  3987. 8
    Metabolism probes for therapy and diagnosis
    Vanderbilt University
    05/25/19
  3988. 5
    Organic compounds
    Intra-Cellular Therapies
    05/25/19
  3989. 32
    PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
    Mitobridge
    05/25/19
  3990. 11
    Pharmaceutical compositions and methods of use of 4-pregenen-11β-17-21-triol-3,20-dione derivatives
    Allergan
    05/25/19
  3991. 103
    Pharmacologically active compounds
    Cancer Research Technology
    05/25/19
  3992. 191
    SGC stimulators
    Ironwood Pharmaceuticals
    05/25/19
  3993. 73
    Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents
    Bayer Pharma Aktiengesellschaft
    05/25/19
  3994. 162
    Substituted pyridines as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    05/25/19
  3995. 7
    Tetrahydrothiophene-based GABA aminotransferase inactivators
    Northwestern University
    05/25/19
  3996. 80
    Autotaxin inhibitors
    Novartis
    05/20/19
  3997. 57
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals
    05/20/19
  3998. 100
    Compounds and compositions as inhibitors of MEK
    Novartis
    05/20/19
  3999. 149
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    05/20/19
  4000. 63
    Fused amino pyridine as HSP90 inhibitors
    Curis
    05/20/19
  4001. 19
    Multitarget FAAH and COX inhibitors and therapeutical uses thereof
    Fondazione Istituto Italiano Di Tecnologia
    05/20/19
  4002. 77
    Oxoazetidine derivatives, process for the preparation thereof and use thereof in human medicine and in cosmetics
    Galderma Research & Development
    05/20/19
  4003. 29
    Pharmaceutically active pyrazine derivatives
    Sentinel Oncology
    05/20/19
  4004. 407
    1,3-thiazol-2-yl substituted benzamides
    Bayer Aktiengesellschaft
    05/16/19
  4005. 74
    2-aryl- and 2-arylalkyl-benzimidazoles as mIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    05/16/19
  4006. 60
    5H-pyrido[3,2-B]indole compounds as anticancer agents
    Bristol-Myers Squibb
    05/16/19
  4007. 135
    6-morpholinyl-2-pyrazolyl-9H-purine derivatives and their use as PI3K inhibitors
    Daiichi Sankyo
    05/16/19
  4008. 78
    Aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amides as somatostatin receptor subtype 4 (SSTR4) agonists
    Boehringer Ingelheim International
    05/16/19
  4009. 200
    Autotaxin inhibitors
    Novartis
    05/16/19
  4010. 36
    Compounds as diacylglycerol acyltransferase inhibitors
    Glaxosmithkline
    05/16/19
  4011. 28
    Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
    Universite De Lille 2 Droit Et Sante
    05/16/19
  4012. 116
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    05/16/19
  4013. 205
    Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors
    Merck Sharp & Dohme
    05/16/19
  4014. 21
    Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
    Redx Pharma
    05/16/19
  4015. 62
    Fused pyridines as kinase inhibitors
    Bristol-Myers Squibb
    05/16/19
  4016. 300
    Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors
    Axovant Sciences
    05/16/19
  4017. 22
    Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof
    Shanghai Huilun Life Science & Technology
    05/16/19
  4018. 103
    Histone demethylase inhibitors
    Celgene Quanticel Research
    05/16/19
  4019. 4
    Inhibitors of RET
    Blueprint Medicines
    05/16/19
  4020. 10
    Isoxazole carboxamides as irreversible SMYD inhibitors
    Epizyme
    05/16/19
  4021. 16
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    05/16/19
  4022. 132
    Melanocortin receptor-specific peptides
    Palatin Technologies
    05/16/19
  4023. 14
    Oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
    Hoffmann-La Roche
    05/16/19
  4024. 64
    Pyrazole compound
    Sumitomo Dainippon Pharma
    05/16/19
  4025. 49
    Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
    Astrazeneca
    05/16/19
  4026. 10
    Pyridone or pyrimidone derivative, preparation method therefor and application thereof
    Sichuan Haisco Pharmaceutical
    05/16/19
  4027. 335
    Pyrimido-pyridazinone compounds and methods of use thereof
    Asana Biosciences
    05/16/19
  4028. 110
    Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
    Taiho Pharmaceutical
    05/16/19
  4029. 36
    Rho kinase inhibitors
    Kadmon
    05/16/19
  4030. 42
    Spiro-cyclic amine derivatives as S1P modulators
    Abbvie
    05/16/19
  4031. 258
    Substituted 2-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    05/16/19
  4032. 143
    Substituted oxopyridine derivatives and use thereof cardiovascular disorders
    Bayer Pharma Aktiengesellschaft
    05/16/19
  4033. 716
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    05/16/19
  4034. 716
    Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    05/16/19
  4035. 121
    Therapeutic compounds and uses thereof
    Genentech
    05/16/19
  4036. 45
    Triazolo[4,5-D]pyrimidines
    Hoffmann-La Roche
    05/16/19
  4037. 17
    Tricyclic compounds and uses thereof in medicine
    Sunshine Lake Pharma
    05/16/19
  4038. 384
    sGC stimulators
    Ironwood Pharmaceuticals
    05/16/19
  4039. 411
    1,3-thiazol-2-yl substituted benzamides
    Beyer Aktiengesellschaft
    05/15/19
  4040. 15
    2-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists
    Merck Sharp & Dohme
    05/15/19
  4041. 3
    Amino-pyrimidine-containing spleen tyrosine kinase (Syk) inhibitors
    Merck Sharp & Dohme
    05/15/19
  4042. 18
    Aminoindazole derivatives as sodium channel inhibitors
    Almirall
    05/15/19
  4043. 8
    Aniline derivatives, their preparation and their therapeutic application
    Sanofi
    05/15/19
  4044. 27
    Benzimidazole derivatives as kinase inhibitors
    Selvita
    05/15/19
  4045. 32
    Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
    Pfizer
    05/15/19
  4046. 15
    Compounds and methods for inhibition of AP endonuclease-1/redox factor-1 (HAPE1) activity
    University Of Pittsburgh
    05/15/19
  4047. 207
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    05/15/19
  4048. 156
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals
    05/15/19
  4049. 61
    Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
    Forma Therapeutics
    05/15/19
  4050. 22
    Heteroaryl compounds as sodium channel blockers
    Purdue Pharma
    05/15/19
  4051. 24
    Heterocyclic compounds and methods for their use
    Novartis
    05/15/19
  4052. 83
    Heterocyclic compounds and methods of their use
    Novartis
    05/15/19
  4053. 98
    Heterocyclic compounds, process for preparation of the same and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    05/15/19
  4054. 12
    IDO inhibitors
    Bristol-Myers Squibb
    05/15/19
  4055. 370
    Inhibitors of ERK and methods of use
    Kura Oncology
    05/15/19
  4056. 20
    Inhibitors of bruton's tyrosine kinase
    F. Hoffmann-La Roche
    05/15/19
  4057. 28
    Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
    Signal Pharmaceuticals
    05/15/19
  4058. 5
    N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine
    Glucox Biotech
    05/15/19
  4059. 12
    Nuclear receptor binding agents
    Gtx
    05/15/19
  4060. 27
    Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease
    Novartis
    05/15/19
  4061. 15
    Pyridazinone macrocycles as IRAK inhibitors and uses thereof
    Merck Patent
    05/15/19
  4062. 6
    Pyridine compounds used as PI3 kinase inhibitors
    Teligene
    05/15/19
  4063. 32
    Pyrido[2,3-d]pyrimidin-4-one compounds as tankyrase inhibitors
    Eli Lilly
    05/15/19
  4064. 18
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer
    05/15/19
  4065. 6
    Substituted 6,5-fused bicyclic heteroaryl compounds
    Epizyme
    05/15/19
  4066. 21
    Substituted bipiperidinyl derivatives
    Bayer Pharma Aktiengesellschaft
    05/15/19
  4067. 46
    Substituted heterocyclic derivative, preparation method and use thereof
    Xiamen University
    05/15/19
  4068. 14
    Substituted piperidinyltetrahydroquinolines
    Bayer Pharma Aktiengesellschaft
    05/15/19
  4069. 52
    Substituted quinazolines for inhibiting kinase activity
    Neupharma
    05/15/19
  4070. 589
    Sulfone amide linked benzothiazole inhibitors of endothelial lipase
    Bristol-Myers Squibb
    05/15/19
  4071. 277
    Tricyclic heterocycles as BET protein inhibitors
    Incyte
    05/15/19
  4072. 17
    URAT1 inhibitor
    Nippon Chemiphar
    05/15/19
  4073. 36
    Thioether-piperidinyl orexin receptor antagonists
    Merck Sharp & Dohme
    05/10/19
  4074. 150
    4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity
    Virostatics
    05/08/19
  4075. 62
    Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones
    Janssen Ireland
    05/08/19
  4076. 86
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    05/08/19
  4077. 44
    Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases
    Abbvie Deutschland
    05/08/19
  4078. 68
    Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
    Beigene
    05/08/19
  4079. 45
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    05/08/19
  4080. 8
    Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
    Laboratories Del Dr. Esteve
    05/08/19
  4081. 34
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche
    05/08/19
  4082. 216
    Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
    Biogen Ma
    05/08/19
  4083. 96
    N-substituted pyrazolo [3,4-D] pyrimidine ketone compound, and preparation process and use thereof
    Sun Yat-Sen University
    05/08/19
  4084. 88
    Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
    North Carolina Central University
    05/08/19
  4085. 13
    Pyridin-4-yl derivatives
    Actelion Pharmaceuticals
    05/08/19
  4086. 315
    Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
    Pfizer
    05/08/19
  4087. 11
    Substituted pyridinone compounds as MEK inhibitors
    Cmg Pharmaceutical
    05/08/19
  4088. 72
    Triazolo compounds
    Hoffmann-La Roche
    05/08/19
  4089. 10
    Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
    Newlink Genetics
    05/08/19
  4090. 15
    1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
    Astrazeneca
    05/07/19
  4091. 48
    Alkynyl indazole derivative and use thereof
    Senju Pharmaceutical
    05/07/19
  4092. 77
    Rho kinase inhibitors and methods of use
    H. Lee Moffitt Cancer Center And Research Institute
    05/07/19
  4093. 122
    2,4-diaminopyrimidine derivatives as histamine H4 modulators
    Janssen Pharmaceutica
    04/30/19
  4094. 330
    Arylquinazolines
    Merck Patent
    04/30/19
  4095. 42
    Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
    Incyte
    04/30/19
  4096. 95
    Combination pharmaceutical compositions and uses thereof
    Intellikine
    04/30/19
  4097. 14
    Inhibitors of CYP17A1
    University Of Kansas
    04/30/19
  4098. 11
    Insulin sensitisers and methods of treatment
    Naia Metabolic
    04/30/19
  4099. 59
    Permeable glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    04/30/19
  4100. 79
    Piperidine derivatives
    Hoffmann-La Roche
    04/30/19
  4101. 259
    Substituted 2-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    04/30/19
  4102. 814
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    04/30/19
  4103. 556
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    04/30/19
  4104. 157
    Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
    Bayer Pharma Aktiengesellschaft
    04/30/19
  4105. 389
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals
    04/30/19
  4106. 39
    1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
    Laboratorios Del Dr. Esteve
    04/29/19
  4107. 34
    1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
    Angelini Acraf
    04/29/19
  4108. 177
    Antiproliferative benzo [B] azepin-2-ones
    Hoffmann-La Roche
    04/29/19
  4109. 15
    Compounds for the treatment and prevention of retroviral infections
    Kflp Biotech
    04/29/19
  4110. 12
    Compounds for the treatment of addiction
    Gilead Sciences
    04/29/19
  4111. 93
    Histone demethylase inhibitors
    Celgene Quanticel Research
    04/29/19
  4112. 10
    Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
    President And Fellows Of Harvard College
    04/29/19
  4113. 8
    Oxazolidinone and imidazolidinone compounds
    Hoffmann-La Roche
    04/29/19
  4114. 397
    Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
    Amgen
    04/29/19
  4115. 151
    Pyridine compounds and the uses thereof
    Purdue Pharma
    04/29/19
  4116. 129
    Substituted 2-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    04/29/19
  4117. 192
    Substituted piperidine compounds and their use as orexin receptor modulators
    Janssen Pharmaceutica
    04/29/19
  4118. 3
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica
    04/29/19
  4119. 232
    Substituted tricyclic compounds as FGFR inhibitors
    Incyte Holdings
    04/29/19
  4120. 145
    Therapeutic inhibitory compounds
    Lifesci Pharmaceuticals
    04/29/19
  4121. 79
    Tropomyosin-related kinase (TRK) inhibitors
    Genzyme
    04/29/19
  4122. 111
    1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    04/24/19
  4123. 5
    1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido [2, 3-B]pyrazin- 8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer
    Cancer Research Technology
    04/24/19
  4124. 118
    2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
    Pfizer
    04/24/19
  4125. 9
    2-oxo-3,4-dihydroquinolin-6-yl sulphonamide CPDS and their use as plant growth regulators
    University Of California
    04/24/19
  4126. 15
    5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines
    Hoffmann-La Roche
    04/24/19
  4127. 198
    Alkynyl alcohols and methods of use
    Genentech
    04/24/19
  4128. 37
    Benzodiazepines as bromodomain inhibitors
    Catalyst Therapeutics
    04/24/19
  4129. 21
    Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof
    Bayer Pharma Aktiengesellschaft
    04/24/19
  4130. 305
    Compounds and compositions as RAF kinase inhibitors
    Novartis
    04/24/19
  4131. 69
    Compounds and methods for inhibiting JAK
    Dizal (Jiangsu) Pharmaceutical
    04/24/19
  4132. 95
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    04/24/19
  4133. 20
    Macrocyclic compounds for inhibition of inhibitors of apoptosis
    Ensemble Therapeutics
    04/24/19
  4134. 9
    PAR4 agonist peptides
    Bristol-Myers Squibb
    04/24/19
  4135. 4
    Psychotrophic agents and uses thereof
    Lb Pharmaceuticals
    04/24/19
  4136. 25
    Selective caspase inhibitors and uses thereof
    Genesis Technologies
    04/24/19
  4137. 16
    Small-molecule HSP90 inhibitors
    Memorial Sloan-Kettering Cancer Center
    04/24/19
  4138. 228
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    04/24/19
  4139. 47
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    04/24/19
  4140. 5
    Substituted pyrimidines useful as EGFR-T790M kinase inhibitors
    Jiangsu Medolution
    04/24/19
  4141. 127
    Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
    Northwestern University
    04/24/19
  4142. 119
    Substituted thiazole or oxazole P2X7 receptor antagonists
    Axxam
    04/24/19
  4143. 151
    Substituted triazoles useful as Axl inhibitors
    Rigel Pharmaceuticals
    04/24/19
  4144. 107
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
    Takeda Pharmaceutical
    04/24/19
  4145. 67
    Sulfoximine substituted quinazolines for pharmaceutical compositions
    Evotec International
    04/24/19
  4146. 78
    Tropomyosin-related kinase (Trk) inhibitors
    Genzyme
    04/24/19
  4147. 76
    [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
    Bayer Pharma Aktiengesellschaft
    04/24/19
  4148. 26
    1,2- bis-sulfonamide derivatives as chemokine receptor modulators
    Allergan
    04/23/19
  4149. 465
    5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof
    Genentech
    04/23/19
  4150. 27
    Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
    Albany Molecular Research
    04/23/19
  4151. 2
    Arylpiperazine derivatives and methods of utilizing same
    Reviva Pharmaceuticals
    04/23/19
  4152. 42
    Benzene or thiophene derivative and use thereof as VAP-1 inhibitor
    R-Tech Ueno
    04/23/19
  4153. 251
    Bicyclic thiophenylamide compounds
    Hoffman-La Roche
    04/23/19
  4154. 99
    Highly selective sigma receptor radioligands
    The University Of Mississippi
    04/23/19
  4155. 43
    IAP antagonists
    Bristol-Myers Squibb
    04/23/19
  4156. 80
    Imidazopyridazines as Akt kinase inhibitors
    Bayer Intellectual Property
    04/23/19
  4157. 113
    Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
    Les Laboratoires Servier
    04/23/19
  4158. 12
    Nuclear receptor binding agents
    Gtx
    04/23/19
  4159. 116
    P2X7 modulators
    Janssen Pharmaceutica
    04/23/19
  4160. 27
    Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors
    Iteos Therapeutics
    04/23/19
  4161. 13
    Substituted aminobutyric derivatives as neprilysin inhibitors
    Novartis
    04/23/19
  4162. 7
    Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders
    Caliper Life Sciences
    04/23/19
  4163. 9
    CGRP receptor antagonists
    Heptares Therapeutics
    04/11/19
  4164. 10
    Compounds and methods for the treatment of cancer
    University Of Illinois
    04/11/19
  4165. 7
    2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
    Tiumbio
    04/10/19
  4166. 38
    Amidoethyl azole orexin receptor antagonists
    Merck Sharp & Dohme
    04/10/19
  4167. 233
    Biaryl kinase inhibitors
    Bristol-Myers Squibb
    04/10/19
  4168. 66
    Carboxamide inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    04/10/19
  4169. 91
    Fused azaheterocyclic compounds and their use as AMPA receptor modulators
    Janssen Pharmaceutica
    04/10/19
  4170. 197
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    04/10/19
  4171. 12
    Indazoles and use thereof
    Purdue Pharma
    04/10/19
  4172. 27
    N-aralkylcarbonyl-piperazine and -homopiperazine compounds and personal care compositions comprising the same
    Conopco
    04/10/19
  4173. 127
    Nitrogen-containing saturated heterocyclic compound
    Mitsubishi Tanabe Pharma
    04/10/19
  4174. 27
    Pyrazolyl-substituted heteroaryls and their use as medicaments
    Boehringer Ingelheim International
    04/10/19
  4175. 5
    Ribonucleotide reductase inhibitors and methods of use
    City Of Hope
    04/10/19
  4176. 6
    Screening method
    Iomet Pharma
    04/10/19
  4177. 169
    Somatostatin receptor subtype 4 (SSTR4) agonists
    Centrexion Therapeutics
    04/10/19
  4178. 8
    Substituted amino six-membered saturated heteroalicycles as long-acting DPP-IV inhibitors
    Centaurus Biopharma
    04/10/19
  4179. 111
    Therapeutic compounds and uses thereof
    Genentech
    04/10/19
  4180. 3
    1,4-pyridone bicycic heteroaryl compounds
    Epizyme
    04/09/19
  4181. 89
    ASK1 inhibitor compounds and uses thereof
    Seal Rock Therapeutics
    04/09/19
  4182. 20
    Androgen receptor modulating compounds
    Orion
    04/09/19
  4183. 20
    Antitumor compound targeting IDH2 mutation and method of use thereof
    Chia Tai Tianqing Pharmaceutical Group
    04/09/19
  4184. 185
    Aryl- or heteroaryl-substituted benzene compounds
    Epizyme
    04/09/19
  4185. 65
    Compounds and uses
    Astrazeneca
    04/09/19
  4186. 224
    Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor
    Amgen
    04/09/19
  4187. 17
    Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
    Shanghai Yingli Pharmaceutical
    04/09/19
  4188. 150
    Heteroaryl substituted pyridyl compounds useful as kinase modulators
    Bristol-Myers Squibb
    04/09/19
  4189. 38
    Histone deacetylase inhibitors and their use in therapy
    Karus Therapeutics
    04/09/19
  4190. 352
    Inhibitors of Bruton's tyrosine kinase
    Pharmacyclics
    04/09/19
  4191. 70
    Inhibitors of glutaminyl cyclase
    Probiodrug
    04/09/19
  4192. 286
    P2X7 modulators
    Janssen Pharmaceutica
    04/09/19
  4193. 62
    P2X7 modulators
    Janssen Pharmaceutica
    04/09/19
  4194. 29
    PRMT5 inhibitors and uses thereof
    Epizyme
    04/09/19
  4195. 103
    Pyrazoles
    Janssen Pharmaceuticals
    04/09/19
  4196. 18
    Substituted aminopyrimidine compounds and methods of use
    Calitor Sciences
    04/09/19
  4197. 70
    Substituted benzene compounds
    Epizyme
    04/09/19
  4198. 49
    Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    04/09/19
  4199. 10
    TC-PTP inhibitors as APC activators for immunotherapy
    TBA
    04/09/19
  4200. 92
    Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease
    Lycera
    04/09/19
  4201. 45
    Therapeutic compounds and uses thereof
    Genentech
    04/09/19
  4202. 86
    Trifluoromethyl alcohols as modulators of RORγt
    Janssen Pharmaceutica
    04/09/19
  4203. 10
    Bicyclo[3.2.1]octyl amide derivatives and uses of same
    H. Lundbeck
    04/08/19
  4204. 94
    Heteroarylcarboxylic acid ester derivative
    Ea Pharma
    04/08/19
  4205. 54
    Methods for treating depressive symptoms
    Alkermes Pharma Ireland
    04/08/19
  4206. 102
    Pyrimidines as sodium channel blockers
    TBA
    04/08/19
  4207. 790
    Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie
    04/08/19
  4208. 47
    Ring-contracted morphinans and the use thereof
    Purdue Pharma
    04/08/19
  4209. 77
    Substituted pyridines as sodium channel blockers
    Purdue Pharma
    04/08/19
  4210. 175
    Benzamide-containing compounds and their use in the treatment of pain
    H. Lundbeck
    04/03/19
  4211. 161
    Diazepinone derivatives
    Novartis
    04/03/19
  4212. 13
    Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
    Allergan
    04/03/19
  4213. 10
    Inhibitors
    Probiodrug
    04/03/19
  4214. 11
    Mono-fluoro beta-secretase inhibitors
    Astrazeneca
    04/03/19
  4215. 335
    Pyridine CDK9 kinase inhibitors
    Abbvie
    04/03/19
  4216. 37
    Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
    Shionogi
    04/03/19
  4217. 400
    Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity
    University Of North Carolina At Chapel Hill
    04/03/19
  4218. 15
    6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection
    Hoffmann-La Roche
    03/31/19
  4219. 701
    Alkylene derivatives
    Shionogi
    03/31/19
  4220. 344
    Bridged bicyclic kallikrein inhibitors
    Global Blood Therapeutics
    03/31/19
  4221. 13
    Carboxylic acid compounds
    Sumitomo Dainippon Pharma
    03/31/19
  4222. 72
    Chemical compounds
    Astrazeneca
    03/31/19
  4223. 6
    Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof
    Shenyang Sunshine Pharmaceutical
    03/31/19
  4224. 31
    Compounds for the treatment of hepatitis C
    Bristol-Myers Squibb
    03/31/19
  4225. 7
    Isoxazole derivatives as FXR agonists and methods of use thereof
    Elmore Patent Law Group
    03/31/19
  4226. 3
    OCT3 activity inhibitor containing imidazopyridine derivative as active component, and OCT3 detection agent
    Shin Nippon Biomedical Laboratories
    03/31/19
  4227. 41
    Pyrrolidine orexin receptor antagonists
    Merck Sharp & Dohme
    03/31/19
  4228. 71
    Factor XIa inhibitors
    Merck Sharp & Dohme
    03/30/19
  4229. 14
    Fused triazole derivatives as phosphodiesterase 10A inhibitors
    Celon Pharma
    03/30/19
  4230. 5
    Hydroxy-substituted amino and ammonium derivatives and their medical use
    Gri Bio
    03/30/19
  4231. 28
    Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    03/30/19
  4232. 28
    Immunomodulators
    Bristol-Myers Squibb
    03/30/19
  4233. 8
    Isoxazole analogs as FXR agonists and methods of use thereof
    Enanta Pharmaceuticals
    03/30/19
  4234. 1
    Methods for treating cancer
    Epizyme
    03/30/19
  4235. 78
    Methods of treating fibrosis, cancer and vascular injuries
    Ewha University—Industry Collaboration Foundation
    03/30/19
  4236. 257
    Nrf2 regulators
    Glaxosmithkline
    03/30/19
  4237. 407
    Piperazine derivatives as liver X receptor modulators
    Vitae Pharmaceuticals
    03/30/19
  4238. 35
    Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives
    Pfizer
    03/30/19
  4239. 112
    Pyrazolopyridine derivatives and their use in therapy
    TBA
    03/30/19
  4240. 26
    Pyrrolobenzodiazepines and conjugates thereof
    Mersana Therapeutics
    03/30/19
  4241. 520
    Quinoxaline compounds and uses thereof
    Millennium Pharmaceuticals
    03/30/19
  4242. 812
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    03/30/19
  4243. 20
    Triazolopyridines and triazolopyrazines as LSD1 inhibitors
    Incyte
    03/30/19
  4244. 46
    1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors
    Bayer Pharma Aktiengesellschaft
    03/29/19
  4245. 7
    2-oxothiazole compounds and method of using same for chronic inflammatory disorders
    Avexxin
    03/29/19
  4246. 65
    Amino compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    03/29/19
  4247. 111
    Aminoquinazoline compounds as A2A antagonist
    Merck Sharp & Dohme
    03/29/19
  4248. 41
    Antibacterial piperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones
    Janssen Ireland
    03/29/19
  4249. 6
    Antibody-drug conjugates and immunotoxins
    Oncomatryx Biopharma
    03/29/19
  4250. 123
    Autotaxin inhibitors
    Cancer Research Technology
    03/29/19
  4251. 79
    Benzazepine dicarboxamide compounds
    Hoffmann-La Roche
    03/29/19
  4252. 35
    Benzimidazol-2-amines as MIDH1 inhibitors
    Bayer Pharma Aktiengesellschaft
    03/29/19
  4253. 26
    Benzonapthyridine compositions and uses thereof
    Glaxosmithkline
    03/29/19
  4254. 36
    Bicyclic heteroaryl derivatives as CFTR potentiators
    Cystic Fibrosis Foundation Therapeutics
    03/29/19
  4255. 70
    Chemical compounds
    Astrazeneca
    03/29/19
  4256. 261
    Compounds as modulators of RORγ
    Boehringer Ingelheim International
    03/29/19
  4257. 4
    Compounds useful for inhibiting ROR-gamma-t
    Eli Lilly
    03/29/19
  4258. 2
    Crystal of 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative
    Daiichi Sankyo
    03/29/19
  4259. 48
    Drugs for treating respiratory diseases
    Daiichi Sankyo
    03/29/19
  4260. 33
    Factor xia-inhibiting pyridobenzazepine and pyridobenzazocine derivatives
    Bayer Pharma Aktiengesellschaft
    03/29/19
  4261. 149
    Heteroaromatic compounds as BTK inhibitors
    Boehringer Ingelheim International
    03/29/19
  4262. 103
    Imidazopyridazine compounds
    Pfizer
    03/29/19
  4263. 65
    Indanyloxydihydrobenzofuranylacetic acids
    Boehringer Ingelheim International
    03/29/19
  4264. 158
    Inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    03/29/19
  4265. 174
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    03/29/19
  4266. 4
    Isoxazole derivatives as FXR agonists and methods of use therof
    Enanta Pharmaceuticals
    03/29/19
  4267. 116
    Kinase inhibitors and methods of use thereof
    The Broad Institute
    03/29/19
  4268. 4
    Organic compounds
    Intra-Cellular Therapies
    03/29/19
  4269. 14
    Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
    Purdue Pharma
    03/29/19
  4270. 41
    Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
    Janssen Ireland
    03/29/19
  4271. 24
    Prolyl hydroxylase inhibitors and methods of use
    Akebia Therapeutics
    03/29/19
  4272. 17
    SMYD2 inhibitors
    Abbvie
    03/29/19
  4273. 64
    Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
    Sanofi
    03/29/19
  4274. 421
    Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors
    Bristol-Myers Squibb
    03/29/19
  4275. 120
    Substituted benzamides as RIPK2 inhibitors
    Boehringer Ingelheim International
    03/29/19
  4276. 97
    Substituted benzamides as RIPK2 inhibitors
    Boehringer Ingelheim International
    03/29/19
  4277. 73
    Substituted benzimidazole-type piperidine compounds and uses thereof
    Purdue Pharma
    03/29/19
  4278. 83
    Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer
    Bayer Intellectual Property
    03/29/19
  4279. 18
    Substituted bicyclic heteroaryl compounds
    Bristol-Myers Squibb
    03/29/19
  4280. 46
    Substituted heteroaryl compounds and methods of use thereof
    Sunshine Lake Pharma
    03/29/19
  4281. 37
    Substituted indazole derivatives active as kinase inhibitiors
    Nerviano Medical Sciences
    03/29/19
  4282. 557
    Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    03/29/19
  4283. 231
    Substituted tricyclic compounds as FGFR inhibitors
    Incyte
    03/29/19
  4284. 19
    Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
    Janssen Pharmaceutica
    03/29/19
  4285. 44
    Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
    Merck Sharp & Dohme
    03/29/19
  4286. 9
    Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
    The University Of Pittsburgh—Of The Commonwealth System Of Higher Education
    03/29/19
  4287. 152
    Tricyclic DLK inhibitors and uses thereof
    Genentech
    03/29/19
  4288. 129
    Urea and amide derivatives of aminoalkylpiperazines and use thereof
    Southern Research Institute
    03/29/19
  4289. 43
    Vasopressin-2 receptor agonists
    Ferring
    03/29/19
  4290. 70
    Amido thiadiazole derivatives as NADPH oxidase inhibitors
    Genkyotex Suisse
    03/28/19
  4291. 34
    Anti-alphavbeta1 integrin compounds and methods
    The Regents Of The University Of California
    03/28/19
  4292. 33
    Benzofurans substituted with primary benzamide as HCV inhibitors
    Bristol-Myers Squibb
    03/28/19
  4293. 9
    Chemical compounds
    Astrazeneca
    03/28/19
  4294. 253
    Compounds
    Bayer Pharma Aktiengesellschaft
    03/28/19
  4295. 4
    Compounds for treatment of cystic fibrosis
    Abbvie S.á.R.L.
    03/28/19
  4296. 64
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    03/28/19
  4297. 97
    Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
    Janssen Pharmaceutica
    03/28/19
  4298. 9
    [7,6]-fused bicyclic antidiabetic compounds
    Merck Sharp & Dohme
    03/28/19
  4299. 405
    Axl inhibitors
    Pfizer
    03/15/19
  4300. 22
    Compounds and compositions as protein kinase inhibitors
    Array Biopharma
    03/15/19
  4301. 23
    Compounds and compositions as protein kinase inhibitors
    Array Biopharma
    03/15/19
  4302. 20
    Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors
    Recordati Ireland
    03/15/19
  4303. 97
    Triazolo[4,5-D]pyrimidine derivatives
    Hoffmann-La Roche
    03/15/19
  4304. 214
    Aminoquinazoline and pyridopyrimidine derivatives
    Genentech
    03/14/19
  4305. 144
    Cyclic amines
    H. Lundbeck
    03/14/19
  4306. 168
    Neprilysin inhibitors
    Theravence Biopharma R&D Ip
    03/14/19
  4307. 125
    Substituted imidazoles as PDE10A inhibitors
    H. Lundbeck
    03/14/19
  4308. 29
    5-HT3 receptor antagonists
    Takeda Pharmaceutical
    03/12/19
  4309. 26
    Crystalline forms of a PI3K inhibitor
    Incyte
    03/12/19
  4310. 83
    Imide and acylurea derivatives as modulators of the glucocorticoid receptor
    Bristol-Myers Squibb
    03/12/19
  4311. 14
    Indole substituted pyrrolopyrimidinyl inhibitors of Uba6
    Millennium Pharmaceuticals
    03/12/19
  4312. 406
    Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
    Amgen
    03/12/19
  4313. 27
    Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    03/12/19
  4314. 18
    1- [1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
    Universitat De Barcelona
    03/11/19
  4315. 97
    Benzofuran compounds for the treatment of hepatitis C
    Bristol-Myers Squibb
    03/11/19
  4316. 10
    Benzofurans substituted with bicyclic secondary benzamide as HCV inhibitors
    Bristol-Myers Squibb
    03/11/19
  4317. 7
    Bromodomain inhibitors
    Tensha Therapeutics
    03/11/19
  4318. 47
    Chemical compounds
    Astrazeneca
    03/11/19
  4319. 20
    Factor XIa inhibitors
    Merck Sharp & Dohme
    03/11/19
  4320. 450
    Heteroaryl compounds and their use as therapeutic drugs
    Dong-A Socio Holdings
    03/11/19
  4321. 20
    Immune system modulators
    Janus Biotherapeutics
    03/11/19
  4322. 45
    Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    03/11/19
  4323. 7
    Inhibitors of protein methyltransferase DOT1L and methods of use thereof
    Epizyme
    03/11/19
  4324. 53
    Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
    Effector Therapeutics
    03/11/19
  4325. 7
    Isoindolinone derivatives useful as antiviral agents
    Viiv Healthcare
    03/11/19
  4326. 548
    Kappa opioid ligands
    The Scripps Research Institute
    03/11/19
  4327. 10
    Kinase inhibitors
    Topivert Pharma
    03/11/19
  4328. 58
    N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors
    Active Biotech
    03/11/19
  4329. 47
    Neprilysin inhibitors
    Theravance Biopharma R&D Ip
    03/11/19
  4330. 3
    Nonanoic and decanoic acid derivatives and uses thereof
    Scifluor Life Sciences
    03/11/19
  4331. 48
    PRMT5 inhibitors and uses thereof
    Epizyme
    03/11/19
  4332. 459
    Piperidinylpyrazolopyrimidinones and their use
    Bayer Pharma Aktiengesellschaft
    03/11/19
  4333. 13
    Pyridine and pyrazine derivative for the treatment of CF
    Novartis
    03/11/19
  4334. 30
    Rho kinase inhibitors
    Kadmon
    03/11/19
  4335. 210
    Small molecule agonists of neurotensin receptor 1
    Sanford Burnham Prebys Medical Discovery Institute
    03/11/19
  4336. 62
    Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof
    Bayer Pharma Aktiengesellschaft
    03/11/19
  4337. 13
    Substituted [1,2,4]triazolo[1,5-a]pyridines and substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
    Incyte
    03/11/19
  4338. 14
    Targeted therapeutics
    Madrigal Pharmaceuticals
    03/11/19
  4339. 49
    Therapeutic agent for FGFR inhibitor-resistant cancer
    Taiho Pharmaceutical
    03/11/19
  4340. 334
    Tricyclic compounds as anticancer agents
    Bristol-Myers Squibb
    03/11/19
  4341. 2
    Compounds as rearranged during transfection (RET) inhibitors
    Glaxosmithkline
    03/10/19
  4342. 20
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics
    03/04/19
  4343. 397
    3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
    Novartis
    03/04/19
  4344. 20
    Benzoxazepin oxazolidinone compounds and methods of use
    Genentech
    03/04/19
  4345. 37
    Heterocyclic compounds useful as inhibitors of TNF
    Bristol-Myers Squibb
    03/04/19
  4346. 115
    Histone demethylase inhibitors
    Celgene Quanticel Research
    03/04/19
  4347. 247
    Indazolyl thiadiazolamines and related compounds for inhibition of Rho-associated protein kinase and the treatment of disease
    Lycera
    03/04/19
  4348. 32
    Inhibitors of SYK
    Hoffmann-La Roche
    03/04/19
  4349. 248
    Lactams as inhibitors of rock
    Bristol-Myers Squibb
    03/04/19
  4350. 363
    P2X7 modulators and methods of use
    Janssen Pharmaceutica
    03/04/19
  4351. 116
    Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
    Incyte
    03/04/19
  4352. 555
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    03/04/19
  4353. 103
    Tied-back benzamide derivatives as potent rock inhibitors
    Bristol-Myers Squibb
    03/04/19
  4354. 11
    1-(dimethylamino)ethyl-substituted 6H-benzo[C]chromen-6-ones against senile dementia
    Nobel IlaÇ
    03/02/19
  4355. 25
    2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists
    Merck Sharp & Dohme
    03/02/19
  4356. 226
    Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
    Novartis
    03/02/19
  4357. 35
    Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie Deutschland
    03/02/19
  4358. 17
    Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie Deutschland
    03/02/19
  4359. 14
    Antivirals against molluscum contagiosum virus
    University Of Pennsylvania
    03/02/19
  4360. 78
    Aza-heteroaryl compounds as PI3K-gamma inhibitors
    Incyte
    03/02/19
  4361. 449
    Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    03/02/19
  4362. 28
    Heterocyclic GSK-3 allosteric modulators
    Consejo Superior De Investigaciones Cientificas (Csic
    03/02/19
  4363. 27
    Imidazole derivatives
    Hoffmann-La Roche
    03/02/19
  4364. 19
    Inhibitor of bruton's tyrosine kinase
    Centaurus Biopharma
    03/02/19
  4365. 51
    Inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    03/02/19
  4366. 315
    Isoindoline derivatives for use in the treatment of a viral infection
    Viiv Healthcare
    03/02/19
  4367. 4
    Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
    Acea Biosciences
    03/02/19
  4368. 121
    Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
    Bristol-Myers Squibb
    03/02/19
  4369. 6
    Pyrrolopyrimidine compounds and uses thereof
    Hutchinson Medipharma
    03/02/19
  4370. 75
    Substituted cyanoguanidines as oral anti-virals
    Abbvie
    03/02/19
  4371. 13
    Substituted indazoles for treating tendon and/or ligament injuries
    Novartis
    03/02/19
  4372. 19
    Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
    Ono Pharmaceutical
    03/02/19
  4373. 110
    Substituted tricyclic heterocycles as histamine 4 receptor inhibitors
    C&C Research Laboratories
    03/02/19
  4374. 6
    Aza-phenalene-3-ketone derivative, preparation method thereof, and its application as PARP inhibitor
    Suzhou Kangrun Pharmaceuticals
    02/24/19
  4375. 12
    Benzimidazole derivatives as antihistamine agents
    Faes Farma
    02/24/19
  4376. 43
    Compounds inhibiting eukaryotic elongation factor 2 kinase activity
    Longevica Pharmaceuticals
    02/24/19
  4377. 9
    Eckol derivatives, methods of synthesis and uses thereof
    Phloronol
    02/24/19
  4378. 22
    HCV polymerase inhibitors
    Medivir
    02/24/19
  4379. 45
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    02/24/19
  4380. 216
    Histone demethylase inhibitors
    Celgene Quanticel Research
    02/24/19
  4381. 237
    Isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed
    02/24/19
  4382. 416
    Nuclear receptor modulators
    Abbvie
    02/24/19
  4383. 6
    Preparation method for benzoxazoleoxazine ketone compound and intermediate and crystal form thereof
    North China Pharmaceutical New Drug R&D
    02/24/19
  4384. 68
    Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    02/24/19
  4385. 47
    Quinazoline heterocyclic compound as EGFR kinase inhibitor and preparation and application thereof
    Beijing Scitech-Mq Pharmaceuticals
    02/24/19
  4386. 70
    Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
    Janssen Pharmaceutica
    02/24/19
  4387. 59
    Substituted isoxazoles for treating cancer
    Epizyme
    02/24/19
  4388. 43
    Substituted tetrahydrocarbazole and carbazole carboxamide compounds
    Bristol-Myers Squibb
    02/24/19
  4389. 36
    3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators
    Janssen Pharmaceutica
    02/21/19
  4390. 13
    Carboxymethyl piperidine derivative
    Kissei Pharmaceutical
    02/21/19
  4391. 14
    Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof
    Shenyang Sunshine Pharmaceutical
    02/21/19
  4392. 364
    Fused heterocyclic compounds as CaM kinase inhibitors
    Gilead Sciences
    02/21/19
  4393. 7
    Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
    Abbvie Deutschland
    02/21/19
  4394. 198
    Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
    Sk Biopharmaceuticals
    02/21/19
  4395. 30
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    02/21/19
  4396. 27
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D Ip
    02/21/19
  4397. 72
    N2-(2-methoxyphenyl)pyrimidine derivative, method for preparing same, and pharmaceutical composition for cancer prevention or treatment containing same as active ingredient
    Korea Research Institute Of Chemical Technology
    02/21/19
  4398. 6
    Organic compounds
    Intra-Cellular Therapies
    02/21/19
  4399. 300
    Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones
    Dart Neuroscience (Cayman
    02/21/19
  4400. 243
    Triazolopyrimidine compounds and uses thereof
    Novartis
    02/21/19
  4401. 10
    [5,6]—fused bicyclic antidiabetic compounds
    Merck Sharp & Dohme
    02/21/19
  4402. 52
    Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
    Incyte
    02/19/19
  4403. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    02/19/19
  4404. 56
    C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    02/19/19
  4405. 295
    Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
    Merck Patent
    02/19/19
  4406. 21
    Compounds
    Proximagen
    02/19/19
  4407. 21
    Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
    Galderma Research & Development
    02/19/19
  4408. 84
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical
    02/19/19
  4409. 473
    Inhibitors of syk and JAK protein kinases
    Portola Pharmaceuticals
    02/19/19
  4410. 4
    Radiolabeled compounds and their use as radiotracers for quantitative imaging of phosphodiesterase (PDE10A) in mammals
    Takeda Pharmaceutical
    02/19/19
  4411. 10
    Substituted sulfonamide compounds
    Hoffmann-La Roche
    02/19/19
  4412. 13
    Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
    Karus Therapeutics
    02/19/19
  4413. 101
    (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
    Bayer Pharma Aktiengesellschaft
    02/18/19
  4414. 83
    Amide derivatives as lysophosphatidic acid receptor antagonists
    Takeda Pharmaceutical
    02/18/19
  4415. 66
    Arginase inhibitors as therapeutics
    Mars
    02/18/19
  4416. 53
    Condensed ring derivative, and preparation method, intermediate, pharmaceutical composition and use thereof
    Shanghai Yingli Pharmaceutical
    02/18/19
  4417. 176
    Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
    Sanford-Burnham Medical Research Institute
    02/18/19
  4418. 5
    Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
    Zhejiang Dtrm Biopharma
    02/18/19
  4419. 3
    Substituted benzene compounds
    Epizyme
    02/18/19
  4420. 37
    2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
    Hoffmann-La Roche
    01/23/19
  4421. 73
    Benzimidazole derivatives as ITK inhibitors
    Principia Biopharma
    01/23/19
  4422. 5
    Coumarin compounds as receptor modulators with therapeutic utility
    Allergan
    01/23/19
  4423. 92
    Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
    Theravance Respiratory
    01/23/19
  4424. 58
    Factor XIa inhibitors
    Merck Sharp & Dohme
    01/23/19
  4425. 11
    IBAT inhibitors for the treatment of liver diseases
    TBA
    01/23/19
  4426. 151
    Inhibitors of leukotriene production
    Boehringer Ingelheim International
    01/23/19
  4427. 119
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    01/23/19
  4428. 88
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    01/23/19
  4429. 29
    Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
    Genentech
    01/23/19
  4430. 217
    Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds
    Dart Neuroscience (Cayman
    01/23/19
  4431. 13
    Tetracyclic pyridone compounds as antivirals
    Novartis
    01/23/19
  4432. 89
    Treatment of dry eye
    Principia Biopharma
    01/23/19
  4433. 292
    1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    Novartis
    01/22/19
  4434. 72
    Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
    The University Of Texas System
    01/22/19
  4435. 6
    Bifunctional compounds and use for reducing uric acid levels
    Acquist
    01/22/19
  4436. 14
    Bifunctional compounds and use for reducing uric acid levels
    Acquist
    01/22/19
  4437. 5
    Ghrelin O-acyl transferase inhibitors
    Eli Lilly
    01/22/19
  4438. 77
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    01/22/19
  4439. 56
    MAGL inhibitors
    Abide Therapeutics
    01/22/19
  4440. 89
    Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof
    Novartis
    01/22/19
  4441. 220
    Sulfoximine substituted quinazolines for pharmaceutical compositions
    Evotec Internatonal
    01/22/19
  4442. 23
    Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb
    01/22/19
  4443. 340
    Heterocyclylamines as PI3K inhibitors
    Incyte Holdings
    01/18/19
  4444. 7
    Necrosis inhibitors
    National Institute Of Biological Sciences, Beijing
    01/18/19
  4445. 133
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    01/18/19
  4446. 14
    Piperidine compound or salt thereof
    Taiho Pharmaceutical
    01/18/19
  4447. 87
    Piperidine derivative and preparation method and pharmaceutical use thereof
    Jiangsu Hengrui Medicine
    01/18/19
  4448. 167
    Spiro-thiazolones
    Hoffmann-La Roche
    01/18/19
  4449. 18
    Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone
    Ucl Business
    01/17/19
  4450. 5
    Aglaroxin C and derivatives as HCV entry inhibitors
    Sri International
    01/17/19
  4451. 19
    Azabicyclo derivatives, process for preparation thereof and medical use thereof
    Shanghai Haiyan Pharmaceutical Technology
    01/17/19
  4452. 192
    Benzamide imidazopyrazine Btk inhibitors
    Merck Sharp & Dohme
    01/17/19
  4453. 32
    Benzofurans substituted with secondary benzamide as HCV inhibitors
    Bristol-Myers Squibb
    01/17/19
  4454. 30
    Compound as WNT signaling inhibitor, composition, and use thereof
    Curegenix
    01/17/19
  4455. 122
    Fused bicylic pyridine compounds and their use as AMPA receptor modulators
    Janssen Pharmaceutica
    01/17/19
  4456. 91
    Imidazopyridazine derivatives as PI3KB inhibitors
    Janssen Pharmaceutica
    01/17/19
  4457. 135
    Metalloenzyme inhibitor compounds
    Viamet Pharmaceuticals (Bermuda
    01/17/19
  4458. 158
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    01/17/19
  4459. 20
    Pyrimidinone compounds and their use
    Takeda Pharmaceutical
    01/17/19
  4460. 22
    Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    01/17/19
  4461. 49
    Quinazolines as biogenic amine transport modulators
    The United States Of America As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institute Of Health
    01/17/19
  4462. 147
    Quinolone derivatives as fibroblast growth factor receptor inhibitors
    Principia Biopharma
    01/17/19
  4463. 25
    Substituted nicotinamide derivatives as kinase inhibitors
    Allergan
    01/17/19
  4464. 160
    Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor
    Japan Tobacco
    01/17/19
  4465. 124
    Tricyclic compounds as inhibitors of mutant IDH enzymes
    Merck Sharp & Dohme
    01/17/19
  4466. 64
    Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
    Vtv Therapeutics
    01/17/19
  4467. 103
    5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum
    University Of Washington Through Its Center For Commercialization
    01/14/19
  4468. 98
    Bicyclo [2.2.1] acid GPR120 modulators
    Bristol-Myers Squibb
    01/14/19
  4469. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
    Jenrin Discovery
    01/14/19
  4470. 105
    Cyclic peptides and use as medicines
    Novartis
    01/14/19
  4471. 3
    Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    01/14/19
  4472. 19
    Imidazopyridyl compounds as aldosterone synthase inhibitors
    Merck Sharp & Dohme
    01/14/19
  4473. 113
    Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
    Bristol-Myers Squibb
    01/14/19
  4474. 5
    Methods of using phthalazinone ketone derivatives
    Jiangsu Hansoh Pharmaceutical
    01/14/19
  4475. 354
    Primary carboxamides as BTK inhibitors
    Abbvie
    01/14/19
  4476. 60
    Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands
    Laboratorios Del Dr. Esteve
    01/14/19
  4477. 168
    Pyrazolopyridines and pyrazolopyrimidines
    Pfizer
    01/14/19
  4478. 17
    Pyridazinone-amides derivatives
    Merck Patent
    01/14/19
  4479. 356
    Quinazolinedione derivative
    Chugai Seiyaku Kabushiki Kaisha
    01/14/19
  4480. 94
    Substituted pyrrolo[3,4-c]pyrazoles as PKC kinase inhibitors
    Pfizer
    01/14/19
  4481. 7
    Triazolopyridyl compounds as aldosterone synthase inhibitors
    Merck Sharp & Dohme
    01/14/19
  4482. 5
    Substituted N-(pyrrolidine-3-yl)-7H-pyrrolo[2,3-D]pyrimidine-4-amine as janus kinase inhibitor
    Yang Ji Chemical
    01/13/19
  4483. 19
    Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-α]pyrazine-2-carboxamides as RSK inhibitors
    Phoenix Molecular Designs
    01/13/19
  4484. 49
    Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof
    Jiangsu Hengrui Medicine
    01/12/19
  4485. 35
    Diamide macrocycles that are FXIa inhibitors
    Bristol-Myers Squibb
    01/12/19
  4486. 94
    Factor XIa inhibitors
    Merck Sharp & Dohme
    01/12/19
  4487. 23
    Heteroaryl compounds and uses thereof
    Celgene Car
    01/12/19
  4488. 12
    Opioid agonists and uses thereof
    Nektar Therapeutics
    01/12/19
  4489. 243
    Aminopyrimidine derivatives for use as modulators of kinase activity
    Merck Patent
    01/11/19
  4490. 26
    Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Incyte
    01/11/19
  4491. 28
    Bicyclic pyridine compound
    Astellas Pharma
    01/11/19
  4492. 494
    Bromodomain inhibitors
    Celgene Quanticel Research
    01/11/19
  4493. 38
    Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
    Allergan
    01/11/19
  4494. 31
    Glucocerebrosidase modulators and uses thereof
    Alectos Therapeutics
    01/11/19
  4495. 23
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    01/11/19
  4496. 115
    Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors
    Bristol-Myers Squibb
    01/11/19
  4497. 104
    Imidazopyridazine compounds
    Pfizer
    01/11/19
  4498. 33
    SHMT inhibitors
    The Trustees Of Princeton University
    01/11/19
  4499. 13
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    01/11/19
  4500. 140
    Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
    Takeda Pharmaceutical
    01/11/19
  4501. 85
    Thiazoles as modulators of RORγt
    Janssen Pharmaceutica
    01/11/19
  4502. 54
    Tricyclic spiro compound
    Ono Pharmaceutical
    01/11/19
  4503. 66
    Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International
    01/10/19
  4504. 39
    G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
    The Regents Of The University Of Michigan
    01/10/19
  4505. 150
    Heteroaryl substituted pyridyl compounds useful as kinase modulators
    Bristol-Myers Squibb
    01/10/19
  4506. 715
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma
    01/10/19
  4507. 59
    Aryl-cyanoguanidine compounds
    Bayer Pharma Aktiengesellschaft
    01/06/19
  4508. 74
    Fumagillol heterocyclic compounds and methods of making and using same
    Zafgen
    01/06/19
  4509. 119
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research
    01/06/19
  4510. 131
    Substituted azetidine derivatives
    Hoffman-La Roche
    01/06/19
  4511. 312
    Therapeutic inhibitory compounds
    Lifesci Pharmaceuticals
    01/06/19
  4512. 4
    Azaspiro[4.5] decane derivatives and use thereof
    Purdue Pharma
    01/05/19
  4513. 18
    Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer
    Kainos Medicine
    01/05/19
  4514. 112
    Cyclic sulfone and sulfoximine analogs and uses thereof
    Peloton Therapeutics
    01/05/19
  4515. 837
    FLAP modulators
    Janssen Pharmaceutica
    01/05/19
  4516. 353
    Fused pyrroledicarboxamides and their use as pharmaceuticals
    Sanofi
    01/05/19
  4517. 4
    Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
    Acetylon Pharmaceuticals
    01/05/19
  4518. 117
    Substituted cinnolines as inhibitors of LRRK2 kinase activity
    Imago Pharmaceuticals
    01/05/19
  4519. 303
    TGF-beta inhibitors
    Rigel Pharmaceuticals
    01/05/19
  4520. 76
    Aza-heteroaryl compounds as PI3K-gamma inhibitors
    Incyte
    12/31/18
  4521. 14
    Branched 3-phenylpropionic acid derivatives and their use
    Bayer Pharma Aktiengesellschaft
    12/31/18
  4522. 18
    Carbazole and tetrahydrocarbazole compounds useful as inhibitors of BTK
    Bristol-Myers Squibb
    12/31/18
  4523. 66
    Cyclobutane containing carboxylic acid GPR120 modulators
    Bristol-Myers Squibb
    12/31/18
  4524. 17
    Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman
    12/31/18
  4525. 774
    Heterocyclic compounds useful as PDK1 inhibitors
    Sunesis Pharmaceuticals
    12/31/18
  4526. 14
    Modulators of ATP-binding cassette transporters
    Vertex Pharmaceuticals
    12/31/18
  4527. 55
    Peptide macrocycles against acinetobacter baumannii
    Hoffmann-La Roche
    12/31/18
  4528. 168
    Pyrazolopyridines and pyrazolopyrimidines
    Pfizer
    12/31/18
  4529. 243
    Pyrrolidine amide compounds as histone demethylase inhibitors
    Genentech
    12/31/18
  4530. 105
    Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles
    Merck Sharp & Dohme
    12/31/18
  4531. 233
    Soluble guanylate cyclase stimulators
    Merck Sharp & Dohme
    12/31/18
  4532. 265
    Spirocycle compounds and methods of making and using same
    Abide Therapeutics
    12/31/18
  4533. 47
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda
    12/31/18
  4534. 36
    Compounds and methods of use
    Medivation Technologies
    12/30/18
  4535. 68
    Disubstituted 1, 2, 4-triazine compound
    Mitsubishi Tanabe Pharma
    12/30/18
  4536. 85
    Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
    Heptares Therapeutics
    12/30/18
  4537. 390
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals
    12/30/18
  4538. 21
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte Holdings
    12/25/18
  4539. 190
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck
    12/25/18
  4540. 11
    Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
    Revivia Pharmaceuticals
    12/25/18
  4541. 61
    Fused amino pyridine as HSP90 inhibitors
    Curis
    12/25/18
  4542. 18
    Guanine analogs as telomerase substrates and telomere length affectors
    Geron
    12/25/18
  4543. 47
    Heterocyclic derivatives and their use in the treatment of neurological disorders
    Novartis
    12/25/18
  4544. 108
    Heterocyclic kinase inhibitors
    Bristol-Myers Squibb
    12/25/18
  4545. 273
    Inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    12/25/18
  4546. 17
    Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
    Saint Louis University
    12/25/18
  4547. 42
    Pyrimidine compounds as JAK kinase inhibitors
    Theravance Biopharma R&D Ip
    12/25/18
  4548. 9
    Quinazoline scaffold based compounds, pharmaceutical compositions and methods of use thereof
    Technion Research & Development Foundation
    12/25/18
  4549. 71
    Resorcinol derivative as HSP90 inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    12/25/18
  4550. 61
    Spirodiamine derivatives as aldosterone synthase inhibitors
    Hoffman-La Roche
    12/25/18
  4551. 37
    Substituted indazole derivatives active as kinase inhibitiors
    Nerviano Medical Sciences
    12/25/18
  4552. 22
    Synergistic combination of immunologic inhibitors for the treatment of cancer
    The University Of Chicago
    12/25/18
  4553. 57
    1,3,4-thiadiazole compounds and their use in treating cancer
    Astrazeneca
    12/22/18
  4554. 17
    1,3,4-thiadiazole compounds and their use in treating cancer
    Astrazeneca
    12/22/18
  4555. 20
    3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection
    Hoffmann-La Roche
    12/22/18
  4556. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Holdings
    12/22/18
  4557. 167
    Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor
    Daiichi Sankyo
    12/22/18
  4558. 115
    Pyrrolopyridazine inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    12/22/18
  4559. 17
    Substituted imidazo[1,5-a]pyrazines as Btk inhibitors
    Merck Sharp & Dohme
    12/22/18
  4560. 109
    Thienopyrazine inhibitors of IRAK4 activity
    Merck Sharp & Dohme
    12/22/18
  4561. 105
    1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
    Samumed
    12/21/18
  4562. 103
    4-azaindole derivatives
    Eisai R&D Management
    12/21/18
  4563. 279
    Crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D Ip
    12/21/18
  4564. 13
    Diacylglycerol acyl transferase 2 inhibitors
    Pfizer
    12/21/18
  4565. 62
    Ethyl N-boc piperidinyl pyrazolo pyridones as Janus kinase inhibitors
    Merck Sharp & Dohme
    12/21/18
  4566. 55
    Histone demethylase inhibitors
    Celgene Quanticel Research
    12/21/18
  4567. 29
    Iminothiadiazine dioxides bearing an amine-linked substituent as BACE inhibitors, compositions, and their use
    TBA
    12/21/18
  4568. 27
    Kinase inhibitors
    Respivert
    12/21/18
  4569. 85
    Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
    Boehringer Ingelheim International
    12/21/18
  4570. 98
    N-substituted benzamides and methods of use thereof
    Genentech
    12/21/18
  4571. 3
    N-sulfonyl homoserine lactone derivatives, preparation method and use thereof
    Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China
    12/21/18
  4572. 17
    Phosphonate compounds
    The Regents Of The University Of California
    12/21/18
  4573. 15
    Pyridone FabI inhibitors and uses thereof
    The Research Foundation For The State University Of New York
    12/21/18
  4574. 7
    Spiro-isoquinoline-3,4′-piperidine compounds having activity against pain
    Esteve Pharmaceuticals
    12/21/18
  4575. 640
    Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
    Janssen Pharmaceutica
    12/21/18
  4576. 111
    Substituted 4-phenylpiperidines, their preparation and use
    Columbia University
    12/21/18
  4577. 14
    Substituted oxopyridine derivatives
    Bayer Pharma Aktiengesellschaft
    12/21/18
  4578. 7
    Substituted pyridine derivatives useful as c-fms kinase inhibitors
    Janssen Pharmaceutica
    12/21/18
  4579. 262
    Tank-binding kinase inhibitor compounds
    Gilead Sciences
    12/21/18
  4580. 611
    Tank-binding kinase inhibitor compounds
    Gilead Sciences
    12/21/18
  4581. 109
    Tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    TBA
    12/21/18
  4582. 14
    2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
    Northwestern University
    12/12/18
  4583. 277
    Acylguanidines for treating osteoarthritis
    Merck Patent
    12/12/18
  4584. 189
    Bicyclic or tricyclic heterocyclic compound
    Mitsubishi Tanabe Pharma
    12/12/18
  4585. 314
    ERK inhibitors
    Merck Sharp & Dohme
    12/12/18
  4586. 95
    Indole carboxamide derivatives as P2X7 receptor antagonists
    Actelion Pharmaceuticals
    12/12/18
  4587. 45
    Piperidinyloxy lactone orexin receptor antagonists
    Merck Sharp & Dohme
    12/12/18
  4588. 4
    Purinone derivative
    Ono Pharmaceutical
    12/12/18
  4589. 45
    Pyridine compounds
    Daiichi Sankyo
    12/12/18
  4590. 128
    Pyrrolopyrrolone derivatives and their use as BET inhibitors
    Novartis
    12/12/18
  4591. 1
    Salt of monocyclic pyridine derivative and crystal thereof
    Eisai R&D Management
    12/12/18
  4592. 214
    Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators
    Beigene
    12/12/18
  4593. 469
    Substituted imidazoles as casein kinase 1 D/E inhibitors
    Bristol-Myers Squibb
    12/12/18
  4594. 467
    Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same
    Nissan Chemical Industries
    12/12/18
  4595. 27
    Substituted spirocycles
    Boehringer Ingelheim International
    12/12/18
  4596. 137
    TRPV1 antagonists including dihydroxy substituent and uses thereof
    Purdue Pharma
    12/12/18
  4597. 78
    Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme
    12/12/18
  4598. 21
    2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treating alzheimer's disease
    H. Lundbeck
    12/11/18
  4599. 18
    2-amino-5,5-difluoro-6-(fluoromethyl)-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
    H. Lundbeck
    12/11/18
  4600. 296
    3-substituted 2-amino-indole derivatives
    Takeda Pharmaceutical
    12/11/18
  4601. 174
    Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors
    Merck Sharp & Dohme
    12/11/18
  4602. 554
    Aminotriazine derivative and pharmaceutical composition comprising the same
    Shionogi
    12/11/18
  4603. 144
    Antidiabetic compounds
    Merck Sharp & Dohme
    12/11/18
  4604. 137
    Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
    Novartis
    12/11/18
  4605. 31
    Chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda
    12/11/18
  4606. 28
    Compounds
    Elanco Tiergesundheit
    12/11/18
  4607. 74
    Compounds and compositions for treating HIV with derivatives of Betulin
    Glaxosmithkline
    12/11/18
  4608. 13
    Compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase
    Beth Israel Deaconess Medical Center
    12/11/18
  4609. 43
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    12/11/18
  4610. 37
    Cot modulators and methods of use thereof
    Gilead Sciences
    12/11/18
  4611. 239
    Heterocyclic compounds as PI3K-γ inhibitors
    Incyte
    12/11/18
  4612. 88
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    12/11/18
  4613. 44
    Histone demethylase inhibitors
    Celgene Quanticel Research
    12/11/18
  4614. 3
    Imidazo[1,2-α]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    12/11/18
  4615. 17
    Imidazo[1,2-A]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication
    Viiv Healthcare Uk (No. 5
    12/11/18
  4616. 9
    Isoquinoline derivatives as MGAT2 inhibitors
    Merck Sharp & Dohme
    12/11/18
  4617. 35
    LSD1 inhibitors
    Mirati Therapeutics
    12/11/18
  4618. 41
    Macrocyclic pyridazinone derivatives
    Merck Patent
    12/11/18
  4619. 582
    Methods of treating heart failure
    Amgen
    12/11/18
  4620. 9
    Protein tyrosine kinase modulators and methods of use
    Betta Pharmaceuticals
    12/11/18
  4621. 148
    Pyridine derivative
    Astellas Pharma
    12/11/18
  4622. 42
    Quinolinone compound and use thereof
    Sunshine Lake Pharma
    12/11/18
  4623. 20
    Substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
    Hoffmann-La Roche
    12/11/18
  4624. 353
    Substituted thiazoles as HIV integrase inhibitors
    Japan Tobacco
    12/11/18
  4625. 210
    Tricyclic PI3K inhibitor compounds and methods of use
    Genentech
    12/11/18
  4626. 952
    [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
    Bristol-Myers Squibb
    12/11/18
  4627. 97
    Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
    Janssen Pharmaceutica
    12/10/18
  4628. 629
    N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals
    Sanofi
    12/10/18
  4629. 431
    2-(morpholin-4-yl)-1,7-naphthyridines
    Bayer Pharma Aktiengesellschaft
    11/29/18
  4630. 483
    BTK Inhibitors
    Merck Sharp & Dohme
    11/29/18
  4631. 91
    Keto-imidazopyridine derivatives as RORc modulators
    Genentech
    11/29/18
  4632. 48
    Macrocyclic compounds as Trk kinase inhibitors
    Array Biopharma
    11/29/18
  4633. 20
    Selective glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    11/29/18
  4634. 86
    Substituted aza-bicyclic imidazole derivatives useful TRPM8 receptor modulators
    Janssen Pharmaceutica
    11/29/18
  4635. 95
    Substituted triazolopyridines and methods of use thereof
    Genentech
    11/29/18
  4636. 111
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    11/28/18
  4637. 181
    Non-nucleoside reverse transcriptase inhibitors
    Merck Sharp & Dohme
    11/28/18
  4638. 123
    Substituted thiazole or oxazole P2X7 receptor antagonists
    Axxam
    11/28/18
  4639. 82
    Bisarylsulfonamides useful in the treatment of inflammation and cancer
    Kancera
    11/27/18
  4640. 111
    Chromenone derivatives
    Astrazeneca
    11/27/18
  4641. 140
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    11/27/18
  4642. 136
    Isoxazole compounds as inhibitors of heat shock proteins
    The Institute Of Cancer Research
    11/27/18
  4643. 99
    Isoxazoline hydroxamic acid derivatives as LpxC inhibitors
    Novartis
    11/27/18
  4644. 2236
    Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same
    Shionogi
    11/27/18
  4645. 373
    Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors
    Amgen
    11/27/18
  4646. 48
    Aniline derivative, pharmaceutical composition containing same, and use thereof
    Kissei Pharmaceutical
    11/16/18
  4647. 9
    Poly (ADP-ribose) polymerase inhibitor
    Chengdu Diao Pharmaceutical Group
    11/16/18
  4648. 6
    Substituted pyridines as sodium channel blockers
    TBA
    11/16/18
  4649. 7
    Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
    Bayer Intellectual Property
    11/15/18
  4650. 33
    Carbazole carboxamide compounds
    Bristol-Myers Squibb
    11/15/18
  4651. 55
    Compositions, methods, and systems for the synthesis and use of imaging agents
    Lantheus Medical Imaging
    11/15/18
  4652. 69
    Compounds and methods for inhibiting JAK
    Astrazeneca
    11/15/18
  4653. 30
    Compounds for treatment of cancer
    Curegenix
    11/15/18
  4654. 7
    Cyclic sulfonamides as sodium channel blockers
    Purdue Pharma
    11/15/18
  4655. 110
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    11/15/18
  4656. 46
    Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3)
    Bayer Pharma Aktiengesellschaft
    11/15/18
  4657. 7
    Heterocyclic compounds and methods of their use
    Novartis
    11/15/18
  4658. 356
    Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
    Boehringer Ingelheim International
    11/15/18
  4659. 147
    Multiple kinase pathway inhibitors
    Tolero Pharmaceuticals
    11/15/18
  4660. 5
    Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
    Zhejiang Dtrm Biopharma
    11/15/18
  4661. 133
    Plasminogen activator inhibitor-1 inhibitors and methods of use thereof
    University Of Michigan
    11/15/18
  4662. 33
    Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease
    Novartis
    11/15/18
  4663. 20
    Quinazoline derivatives, compositions thereof, and use as pharmaceuticals
    Shanghai Fochon Pharmaceutical
    11/15/18
  4664. 14
    Spirocyclic CETP inhibitors
    Merck Sharp & Dohme
    11/15/18
  4665. 217
    Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof
    Sanofi
    11/15/18
  4666. 38
    Substituted piperazine compounds and methods of use thereof
    Sunshine Lake Pharma
    11/15/18
  4667. 33
    Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors
    Almac Discovery
    11/15/18
  4668. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical
    11/08/18
  4669. 77
    Benzoisothiazole compounds and methods of treating schizophrenia
    Shanghai Institute Of Pharmaceutical Industry
    11/08/18
  4670. 59
    Inhibitors of bruton's tyrosine kinase
    F. Hoffmann-La Roche
    11/08/18
  4671. 51
    Azapeptides as CD36 binding compounds
    Valorisation-Recherche, Limited Partnership
    11/07/18
  4672. 24
    Compounds and methods for skin repair
    Allergan
    11/07/18
  4673. 114
    Heterocyclic derivates
    Kalvista Pharmaceuticals
    11/07/18
  4674. 527
    Substituted benzamides and methods of use thereof
    Genentech
    11/07/18
  4675. 36
    Aryl amide-based kinase inhibitors
    Bristol-Myers Squibb
    11/05/18
  4676. 825
    Metallo-beta-lactamase inhibitors
    Merck Sharp & Dohme
    11/05/18
  4677. 131
    Pyrrolopyrimidine nucleosides and analogs thereof
    Chimerix
    11/05/18
  4678. 48
    Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors
    Hoffmann-La Roche
    11/05/18
  4679. 34
    Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors
    Incyte
    11/01/18
  4680. 8
    Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
    Oryzon Genomics
    10/31/18
  4681. 143
    Benzimidazole derivatives as EP4 antagonists
    Bayer Pharma Aktiengesellschaft
    10/31/18
  4682. 187
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte
    10/31/18
  4683. 23
    Flouro-naphthyl derivatives
    Hoffmann-La Roche
    10/31/18
  4684. 139
    Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
    Takeda Pharmaceutical
    10/31/18
  4685. 45
    Sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
    Hoffmann-La Roche
    10/31/18
  4686. 50
    2-acylaminothiazoles for the treatment of cancer
    UniversitÁ
    10/30/18
  4687. 17
    Azabenzimidazole derivatives
    Boehringer Ingelheim International
    10/30/18
  4688. 21
    Cyclohexyl pyridine derivative
    Kissei Pharmaceutical
    10/30/18
  4689. 123
    Cyclohexyl sulfone RORγ modulators
    Bristol-Myers Squibb
    10/30/18
  4690. 73
    Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders
    Bristol-Myers Squibb
    10/30/18
  4691. 11
    Heterocyclic compounds and methods for their use
    Novartis
    10/30/18
  4692. 352
    Heterocyclylamines as PI3K inhibitors
    Incyte Holdings
    10/30/18
  4693. 22
    Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase
    Tes Pharma
    10/30/18
  4694. 3
    Kappa opioid receptor compounds
    Medisynergies
    10/30/18
  4695. 56
    P2X7 modulators
    Janssen Pharmaceutica
    10/30/18
  4696. 19
    Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
    Merck Sharp & Dohme
    10/30/18
  4697. 7
    Process for making isoquinoline compounds
    Fibrogen
    10/30/18
  4698. 91
    Pyrazolyl-ureas as kinase inhibitors
    Respivert
    10/30/18
  4699. 93
    Pyrrolopyrimidine derivatives as TAM inhibitors
    Incyte
    10/30/18
  4700. 12
    ROR modulators and their uses
    Innov17
    10/30/18
  4701. 15
    S1P receptors modulators and their use thereof
    Akaal Pharma
    10/30/18
  4702. 4
    Selective glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    10/30/18
  4703. 13
    Spiropyrrolidines as MDM2 inhibitors
    Hudson Biopharma
    10/30/18
  4704. 41
    Substituted 2-aminopyridine protein kinase inhibitor
    Chia Tai Tianqing Pharmaceutical Group
    10/30/18
  4705. 125
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
    Janssen Pharmaceutica
    10/30/18
  4706. 89
    Substituted spiropiperidinyl compounds useful as GPR120 agonists
    Merck Sharp & Dohme
    10/30/18
  4707. 11
    Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof
    Innov17
    10/30/18
  4708. 298
    Sulfoximine substituted quinazolines for pharmaceutical compositions
    Evotec International
    10/30/18
  4709. 40
    Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
    Hoffmann-La Roche
    10/30/18
  4710. 16
    Therapeutic hydroxyquinolones
    Rutgers, The State University Of New Jersey
    10/30/18
  4711. 25
    Thienopyrimidine compounds
    Hoffman-La Roche
    10/30/18
  4712. 434
    Heterocyclic ring and carbocyclic derivative
    Shionogi
    10/19/18
  4713. 151
    Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors
    Novartis
    10/19/18
  4714. 10
    Androgen receptor antagonists
    The Regents Of The University Of California
    10/18/18
  4715. 88
    Carbazole compounds useful as bromodomain inhibitors
    Bristol-Myers Squibb
    10/18/18
  4716. 111
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    10/18/18
  4717. 22
    Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors
    Ab Science
    10/18/18
  4718. 22
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    10/18/18
  4719. 107
    Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
    Korea Research Institute Of Chemical Technology
    10/18/18
  4720. 247
    Tetrahydro-benzodiazepinones
    Hoffmann-La Roche
    10/18/18
  4721. 245
    6-substituted phenoxychroman carboxylic acid derivatives
    Array Biopharma
    10/17/18
  4722. 168
    Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
    Amgen
    10/17/18
  4723. 7
    C17-aryl substituted betulinic acid analogs
    Viiv Healthcare Uk (No. 5
    10/17/18
  4724. 158
    Imidazopyridines and imidazopyrazines as LSD1 inhibitors
    Incyte
    10/17/18
  4725. 5
    Metalloenzyme inhibitor compounds
    Viamet Pharmaceuticals
    10/17/18
  4726. 60
    N-alkylated indole and indazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    10/17/18
  4727. 29
    N-cyanomethylamides as inhibitors of janus kinase
    Cadila Healthcare
    10/17/18
  4728. 328
    Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
    Cadent Therapeutics
    10/17/18
  4729. 26
    Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
    University Of Utah Research Foundation
    10/17/18
  4730. 101
    Substituted triazolopyridines
    Bayer Intellectual Property
    10/17/18
  4731. 21
    (R)-2-methyl-piperazine derivatives as CXCR3 receptor modulators
    Idorsia Pharmaceuticals
    10/10/18
  4732. 12
    2-amino-6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
    H. Lundbeck
    10/10/18
  4733. 46
    8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and thier use as pharmaceutical compositions
    Boehringer Ingelheim International
    10/10/18
  4734. 11
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    10/10/18
  4735. 37
    Imidazolone derivatives, pharmaceutical compositions and uses thereof
    Beijing Forelandpharma
    10/10/18
  4736. 102
    Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
    Tolero Pharmaceuticals
    10/10/18
  4737. 30
    Aminoquinazoline derivatives and their salts and methods of use thereof
    Sunshine Lake Pharma
    10/05/18
  4738. 37
    Guanidine compound
    Astellas Pharma
    10/03/18
  4739. 23
    PPAR-sparing compounds for the treatment of metabolic diseases
    Metabolic Solutions Development
    10/03/18
  4740. 3
    Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy
    Donesta Bioscience
    10/03/18
  4741. 90
    C5-C6-oxacyclic fused iminopyrimidinone compounds as bace inhibitors, compositions, and their use
    Merck Sharp & Dohme
    10/02/18
  4742. 313
    Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
    Bristol-Myers Squibb
    10/02/18
  4743. 105
    Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
    Array Biopharma
    10/02/18
  4744. 91
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
    Janssen Pharmaceutica
    10/02/18
  4745. 216
    Substituted pyridobenzodiazepinone-derivatives and use thereof
    Bayer Pharma Aktiengesellschaft
    10/02/18
  4746. 11
    Substituted pyrazolopyrimidinylamino-indazoles
    Bayer Pharma Aktiengesellschaft
    09/30/18
  4747. 1155
    2,6,7,8 substituted purines as HDM2 inhibitors
    Merck Sharp & Dohme
    09/26/18
  4748. 4
    Enhancer of zeste homolog 2 inhibitors
    Glaxosmithkline
    09/26/18
  4749. 3
    Substituted-1H-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors
    University Of Utah Research Foundation
    09/26/18
  4750. 115
    2-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists
    Merck Sharp & Dohme
    09/18/18
  4751. 427
    Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators
    Bristol-Myers Squibb
    09/18/18
  4752. 71
    PDE9 inhibitors with imidazo triazinone backbone
    TBA
    09/18/18
  4753. 52
    Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5
    Vanderbilt University
    09/18/18
  4754. 23
    Tertiary amines for use in the treatment of cardiac disorders
    Universitetet I Oslo
    09/18/18
  4755. 10
    2-pyridyloxy-4-ester orexin receptor antagonists
    Merck Sharp & Dohme
    09/07/18
  4756. 15
    Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity
    Shionogi
    09/07/18
  4757. 7
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La
    09/07/18
  4758. 26
    Kinase modulating compounds, compositions containing the same and use thereof
    Centaurus Biopharma
    09/07/18
  4759. 39
    Tetrazole derivatives and their use as potassium channel modulators
    Saniona
    09/07/18
  4760. 38
    6-arylamino pyridone carboxamide as MEK inhibitors
    Centaurus Biopharma
    08/28/18
  4761. 5
    Complement pathway modulators and uses thereof
    Novartis
    08/28/18
  4762. 28
    ERK inhibitors
    Merck Sharp & Dohme
    08/28/18
  4763. 2
    Dihydropyrido pyrimidine compounds as autotaxin inhibitors
    Eli Lilly
    08/25/18
  4764. 76
    HSPC-sparing treatments for RB-positive abnormal cellular proliferation
    Gi Therapeutics
    08/25/18
  4765. 110
    (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
    Boehringer Ingelheim International
    08/24/18
  4766. 272
    Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
    Novartis
    08/24/18
  4767. 19
    15-aryl prostaglandins as EP4 agonists, and methods of use thereof
    Allergan
    08/16/18
  4768. 267
    7-hydroxy-indolinyl antagonists of P2Y1 receptor
    Bristol-Myers Squibb
    08/16/18
  4769. 56
    P2X7 modulators
    Janssen Pharmaceutica
    08/16/18
  4770. 79
    Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof
    Jiangsu Hengrui Medicine
    08/16/18
  4771. 14
    Substituted 1,7-naphthyridines as dopamine D1 ligands
    Pfizer
    08/16/18
  4772. 29
    5-HT3 receptor antagonists
    Takeda Pharmaceutical
    08/07/18
  4773. 174
    Azole derivative
    Taisho Pharmaceutical
    08/07/18
  4774. 19
    Benzimidazole tetrahydrofuran derivatives
    Merck Sharp & Dohme
    08/07/18
  4775. 3
    Compounds useful for producing an optically active diazabicyclooctane compound
    Meiji Seika Pharma
    08/07/18
  4776. 64
    Fused thiazin-3-ones as KCA3.1 inhibitors
    Boehringer Ingelheim International
    08/07/18
  4777. 84
    Fused tricyclic amide compounds as multiple kinase inhibitors
    Beigene
    08/07/18
  4778. 12
    Heteroaryl compounds and methods of use thereof
    Sunovion Pharmaceuticals
    08/07/18
  4779. 105
    Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    Array Biopharma
    08/07/18
  4780. 2
    Modified biotin, mutant streptavidin, and use thereof
    Savid Therapeutics
    08/07/18
  4781. 4
    Pharmacologically active compounds
    The University Of Liverpool
    08/07/18
  4782. 2
    Pyrimido-diazepinone compounds and methods of treating disorders
    Dana-Farber Cancer Institute
    08/07/18
  4783. 58
    Pyrrolidino heterocycles
    Hoffmann-La Roche
    08/07/18
  4784. 14
    Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
    Sanofi
    08/07/18
  4785. 166
    Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of metabotropic glutamate receptor 3
    Vanderbilt University
    08/07/18
  4786. 27
    Substituted spirocycles
    Boehringer Ingelheim International
    08/07/18
  4787. 32
    Toll-like receptor 2-agonistic lipopeptides, and method of making the same
    University Of Kansas
    08/07/18
  4788. 45
    Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Hoffmann-La Roche
    07/07/18
  4789. 33
    Cannabinoid-2 agonists
    Allergan
    07/07/18
  4790. 208
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    Galapagos
    07/07/18
  4791. 116
    Cyclopropylamines as LSD1 inhibitors
    Incyte
    07/07/18
  4792. 21
    Fused heterocyclic derivatives as S1P modulators
    Abbvie
    07/07/18
  4793. 101
    Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
    Beigene
    07/07/18
  4794. 188
    Inhibitors of PI3K-delta and methods of their use and manufacture
    Exelixis
    07/07/18
  4795. 24
    Muscarinic agonists
    Acadia Pharmaceuticals
    07/07/18
  4796. 34
    Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor
    East China University Of Science And Technology
    07/07/18
  4797. 48
    Serine/threonine kinase inhibitors
    Array Biopharma
    07/07/18
  4798. 200
    Small molecule myristate inhibitors of Bcr-abl and methods of use
    Dana-Farber Cancer Institute
    07/07/18
  4799. 57
    (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
    Oryzon Genomics
    05/19/18
  4800. 170
    1,3-diaminocyclopentane carboxamide derivatives
    Merck Patent
    05/19/18
  4801. 84
    4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
    Bayer Intellectual Property
    05/19/18
  4802. 5
    5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
    Bayer Pharma Aktiengesellschaft
    05/19/18
  4803. 121
    Benzylamine derivatives
    Kalvista Pharmaceuticals
    05/19/18
  4804. 32
    Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders
    Janssen Pharmaceutica
    05/19/18
  4805. 13
    Cyclosporin analogues for preventing or treating hepatitis C infection
    Enanta Pharmaceuticals
    05/19/18
  4806. 3
    Glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    05/19/18
  4807. 110
    Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors
    H. Lundbeck
    05/19/18
  4808. 182
    MNK inhibitors and methods related thereto
    Effector Therapeutics
    05/19/18
  4809. 104
    Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
    Pfizer
    05/19/18
  4810. 115
    Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
    Nerviano Medical Sciences
    05/19/18
  4811. 65
    Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
    Arrien Pharmaceuticals
    05/19/18
  4812. 83
    Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
    Allergan
    05/19/18
  4813. 39
    Substituted aminopyrimidine compounds and methods of use
    Calitor Sciences
    05/19/18
  4814. 273
    Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    05/19/18
  4815. 21
    Substituted triazolopyridines
    Bayer Pharma Aktiengesellschaft
    05/19/18
  4816. 12
    Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
    Merck Sharp & Dohme
    05/19/18
  4817. 46
    Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
    Novartis
    05/19/18
  4818. 17
    2-benzyl-benzimidazole complement factor B inhibitors and uses thereof
    Novartis
    04/16/18
  4819. 33
    BET bromodomain inhibitors and therapeutic methods using the same
    The Regents Of The University Of Michigan
    04/16/18
  4820. 111
    Compounds and compositions for the inhibition of NAMPT
    Forma Tm
    04/16/18
  4821. 95
    Cyclopropylamine derivatives useful as LSD1 inhibitors
    Oryzon Genomics
    04/16/18
  4822. 74
    Ethynyl derivatives
    Hoffmann-La Roche
    04/16/18
  4823. 6
    Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
    Cayman Chemical
    04/16/18
  4824. 29
    Substituted biaryl compound
    Ube Industries
    04/16/18
  4825. 7
    Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines
    Bayer Intellectual Property
    04/12/18
  4826. 160
    Inhibitors of sodium glucose cotransporter 1
    Lexicon Pharmaceuticals
    04/12/18
  4827. 329
    PRMT5 inhibitors and uses thereof
    Epizyme
    04/12/18
  4828. 115
    Piperidine/piperazine derivatives
    Janssen Pharmaceutica
    04/12/18
  4829. 21
    Polyetherimide compositions and methods for the manufacture and use thereof
    Sabic Global Technologies
    04/12/18
  4830. 45
    Substituted thiazolopyrimidines
    Bayer Pharma Aktiengesellschaft
    04/12/18
  4831. 313
    Compositions useful for treating disorders related to kit
    Blueprint Medicines
    03/27/18
  4832. 312
    Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
    Bristol-Myers Squibb
    03/27/18
  4833. 36
    Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases
    Abbvie Deutschland
    03/27/18
  4834. 30
    Substituted condensed pyrimidine compounds
    GrÜNenthal
    03/27/18
  4835. 162
    Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
    Merck Patent
    03/27/18
  4836. 64
    Tyrosine kinase inhibitors
    Principia Biopharma
    03/27/18
  4837. 375
    3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
    Novartis
    03/19/18
  4838. 72
    Long chain base sphingosine kinase inhibitors
    University Of Virginia Patent Foundation
    03/19/18
  4839. 2
    Modulators of fatty acid amide hydrolase
    Janssen Pharmaceutica
    03/19/18
  4840. 113
    Oxazolidinones as modulators of mGluR5
    Bristol-Myers Squibb
    03/19/18
  4841. 50
    Substituted pyrroles active as kinases inhibitors
    Nerviano Medical Sciences
    03/19/18
  4842. 518
    Anti-fibrotic pyridinones
    Intermune
    03/16/18
  4843. 23
    Arylpyrrolopyridine derived compounds as LRRK2 inhibitors
    H. Lundbeck
    03/16/18
  4844. 2
    Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
    Duke University
    03/16/18
  4845. 28
    Inhibitors of indoleamine 2,3-dioxygenase (IDO)
    Bristol-Myers Squibb
    03/16/18
  4846. 25
    Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa
    Sanofi
    03/16/18
  4847. 1
    Methods for treating seizure disorders and pain
    The Regents Of The University Of California
    03/16/18
  4848. 83
    Substituted naphthyridine and quinoline compounds as MAO inhibitors
    Dart Neuroscience (Cayman
    03/16/18
  4849. 47
    Substituted pyrazines as GPR40 agonists
    Janssen Pharmaceutica
    03/12/18
  4850. 325
    Triazine derivative and pharmaceutical composition comprising the same
    Shionogi
    03/12/18
  4851. 8
    Opioid agonists and uses thereof
    Nektar Therapeutics
    03/11/18
  4852. 122
    Amino-substituted isothiazoles
    Bayer Pharma Aktiengesellschaft
    03/10/18
  4853. 11
    Anticancer compounds
    St. Jude Children'S Research Hospital
    03/10/18
  4854. 66
    BMP inhibitors and methods of use thereof
    The Brigham And Women'S Hospital
    03/10/18
  4855. 99
    Benzimidazole inhibitors of the sodium channel
    Degiacomo, Interim Trustee, Mark G.
    03/10/18
  4856. 6
    DP2 antagonist and uses thereof
    Brickell Biotech
    03/10/18
  4857. 11
    Iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
    Ambit Biosciences
    03/10/18
  4858. 223
    Indole carboxamide compounds
    Bristol-Myers Squibb
    03/10/18
  4859. 391
    Multisubstituted aromatic compounds as serine protease inhibitors
    Verseon
    03/10/18
  4860. 34
    Quinuclidine derivatives and medicinal compositions containing the same
    Almirall
    03/10/18
  4861. 2
    Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors
    Bioaxone Biosciences
    03/10/18
  4862. 91
    Tricyclic compounds for use as kinase inhibitors
    FundaciÓN Centro Nacional De Investigaciones Oncologicas Carlos Iii
    03/10/18
  4863. 216
    1,2,5-Substituted benzimidazoles as flap modulators
    Janssen Pharmaceutica
    02/14/18
  4864. 83
    Positive allosteric modulators of mGluR2
    Bristol-Myers Squibb
    02/14/18
  4865. 296
    Protein kinase C inhibitors and uses thereof
    Rigel Pharmaceuticals
    02/14/18
  4866. 6
    Ethynyl derivatives
    Hoffmann-La Roche
    02/13/18
  4867. 75
    Fumagillol heterocyclic compounds and methods of making and using same
    Zafgen
    02/13/18
  4868. 547
    Kappa opioid ligands
    The Scripps Research Institute
    02/13/18
  4869. 49
    N-substituted-5-substituted phthalamic acids as sortilin inhibitors
    H. Lundbeck
    02/13/18
  4870. 127
    Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
    Endorecherche
    02/13/18
  4871. 26
    Phthalazinone compounds and methods for the treatment of cystic fibrosis
    Flatley Discovery Lab
    02/13/18
  4872. 98
    Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof
    Novartis
    02/13/18
  4873. 16
    Pyridine derivatives as soft rock inhibitors
    Redx Pharma
    02/13/18
  4874. 26
    Quinazoline derivative
    Carna Biosciences
    02/13/18
  4875. 95
    Amide compounds, compositions and applications thereof
    Advinus Therapeutics
    02/07/18
  4876. 30
    Bisaryl-bonded aryltriazolones and use thereof
    Bayer Intellectual Property
    02/07/18
  4877. 586
    Combination of kinase inhibitors and uses thereof
    Intellikine
    02/07/18
  4878. 95
    Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
    Theravance Respiratory
    02/07/18
  4879. 236
    Indazole derivatives useful as CB-1 inverse agonists
    Janssen Pharmaceutica
    02/07/18
  4880. 140
    Quinazoline derivatives useful as CB-1 inverse agonists
    Janssen Pharmaceutica
    02/07/18
  4881. 35
    Series of skin-whitening (lightening) compounds
    Unigen
    02/07/18
  4882. 151
    5-HT3 receptor antagonists
    Takeda Pharmaceutical
    02/06/18
  4883. 53
    Amide compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals
    02/06/18
  4884. 6
    Glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    02/06/18
  4885. 92
    Heterocyclic ITK inhibitors for treating inflammation and cancer
    Confluence Life Sciences
    02/06/18
  4886. 41
    3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds
    Hoffmann-La Roche
    01/26/18
  4887. 38
    3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds
    Hoffmann-La Roche
    01/26/18
  4888. 18
    Benzoxazinone derivatives for treatment of skin diseases
    Sixera Pharma
    01/26/18
  4889. 5
    Diazepane derivatives and uses thereof
    Dana-Farber Cancer Institute
    01/26/18
  4890. 51
    Highly selective c-Met inhibitors as anticancer agents
    Cb Therapeutics
    01/26/18
  4891. 6
    Hydroximic acid derivatives and medical applications therof
    Double Rider Medicine
    01/26/18
  4892. 8
    Inhibitor of breast cancer resistance protein (BCRP)
    Millennium Pharmaceuticals
    01/26/18
  4893. 55
    Inhibitors of the fibroblast growth factor receptor
    Blueprint Medicines
    01/26/18
  4894. 17
    Methods and compositions for inhibition of bromodomain-containing proteins
    Convergene
    01/26/18
  4895. 199
    Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase
    Fibrogen
    01/26/18
  4896. 36
    Piperazine derivatives for treating disorders
    The University Of Nottingham
    01/26/18
  4897. 266
    Substituted 7-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    01/26/18
  4898. 119
    Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
    Incyte
    01/26/18
  4899. 158
    Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors
    Incyte
    01/26/18
  4900. 4
    Substituted imidazo[1,5-a]pyrazines as CGRP receptor antagonists
    Bristol-Myers Squibb
    01/26/18
  4901. 13
    Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
    Incyte
    01/26/18
  4902. 5
    Synthetic methods for spiro-oxindole compounds
    Xenon Pharmaceuticals
    01/26/18
  4903. 38
    Thiazole orexin receptor antagonists
    Merck Sharp & Dohme
    01/26/18
  4904. 217
    1,2,6-substituted benzimidazoles as flap modulators
    Janssen Pharmaceutica
    01/19/18
  4905. 382
    Benzamide derivative
    Chugai Seiyaku Kabushiki Kaisha
    01/19/18
  4906. 1061
    Biaryl amide compounds as kinase inhibitors
    Novartis
    01/19/18
  4907. 13
    Ethynyl derivatives
    Hoffmann-La Roche
    01/19/18
  4908. 190
    Heteroaryl compounds and uses thereof
    Celgene Car
    01/19/18
  4909. 12
    IBAT inhibitors for the treatment of liver disease
    Albireo
    01/19/18
  4910. 10
    Methods for the treatment of locally advanced breast cancer
    Celgene
    01/19/18
  4911. 7
    Methods of treating retroviral infections and related dosage regimes
    Chimerix
    01/19/18
  4912. 38
    Pyrazol derivatives
    Hoffmann-La Roche
    01/19/18
  4913. 2
    Substituted pyrazolopyrimidines as kinases inhibitors
    Jiangsu Medolution
    01/19/18
  4914. 50
    Substituted uracils as chymase inhibitors
    Bayer Pharma Aktiengesellschaft
    01/19/18
  4915. 293
    Antiviral compounds
    Hoffmann-La Roche
    01/14/18
  4916. 249
    IRE-1α inhibitors
    Mannkind
    01/14/18
  4917. 574
    Substituted benzamides and methods of use thereof
    Genentech
    01/14/18
  4918. 54
    2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment
    Merck Sharp & Dohme
    12/04/17
  4919. 25
    Benzimidazole tetrahydropyran derivatives
    Merck Sharp & Dohme
    12/04/17
  4920. 6
    Materials and method for inhibiting replication protein A and uses thereof
    Indiana University Research And Technology
    12/04/17
  4921. 119
    Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
    Zhejiang Dtrm Biopharma
    12/04/17
  4922. 45
    Selective inhibition of MALT1 protease by phenothiazine derivatives
    Helmholtz Zentrum Munchen, Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh
    12/04/17
  4923. 116
    Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors
    Ziarco Pharma
    12/04/17
  4924. 104
    Sulfonamide derivative and medicinal use thereof
    Ea Pharma
    12/04/17
  4925. 48
    Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
    Indiana University Research And Technology
    11/27/17
  4926. 29
    Inhibitors
    Probiodrug
    11/27/17
  4927. 77
    Kinase inhibitors
    The Regents Of The University Of California
    11/27/17
  4928. 8
    Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon
    Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”
    11/27/17
  4929. 169
    Purine derivatives as CB2 receptor agonists
    Hoffmann-La Roche
    11/27/17
  4930. 42
    Pyrazine derivatives as CB2 receptor agonists
    Hoffmann-La Roche
    11/27/17
  4931. 37
    Pyrazole compounds as CB2 agonists
    Hoffmann-La Roche
    11/27/17
  4932. 90
    Pyridine derivatives
    Hoffmann-La Roche
    11/27/17
  4933. 145
    Quinazolinone compounds and derivatives thereof
    Amgen
    11/27/17
  4934. 28
    Thienopyranones as kinase and epigenetic inhibitors
    Signal Rx Pharmaceuticals
    11/27/17
  4935. 47
    [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof
    Jiangsu Hansoh Pharmaceutical
    11/27/17
  4936. 42
    4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group
    Bayer Pharma Aktiengesellschaft
    11/20/17
  4937. 363
    5-substituted iminothiazines and their mono- and dioxides as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    11/20/17
  4938. 40
    Amino pyrimidine derivatives
    Novartis
    11/20/17
  4939. 64
    Amino-substituted imidazopyridazines
    Bayer Intellectual Property
    11/20/17
  4940. 10
    Boron-containing small molecules
    Anacor Pharmaceuticals
    11/20/17
  4941. 112
    Diazaspirocycloalkane and azaspirocycloalkane
    Hoffmann-La Roches
    11/20/17
  4942. 76
    Enhancer of zeste homolog 2 inhibitors
    Glaxosmithkline
    11/20/17
  4943. 29
    Inhibitors of beta-secretase
    Vitae Pharmaceutical
    11/20/17
  4944. 247
    Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
    Bristol-Myers Squibb
    11/20/17
  4945. 22
    Substituted aminopyrimidine compounds and methods of use
    Calitor Sciences
    11/20/17
  4946. 25
    Substituted imidazopyridazines
    Bayer Intellectual Property
    11/20/17
  4947. 19
    3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
    Bayer Pharma Aktiengesellschaft
    11/13/17
  4948. 14
    Augmenting moieties for anti-inflammatory compounds
    Rutgers, The State University Of New Jersey
    11/13/17
  4949. 150
    Cycloalkane derivatives
    Daiichi Sankyo
    11/13/17
  4950. 1
    Incontinence treatment methods
    Ixaltis
    11/13/17
  4951. 68
    Inhibitors of D-amino acid oxidase
    The Johns Hopkins University
    11/13/17
  4952. 7
    Inhibitors of glutaminyl cyclase
    Probiodrug
    11/13/17
  4953. 565
    Orexin receptor antagonists which are [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
    Actelion Pharmaceuticals
    11/13/17
  4954. 1
    Polymorphs of N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride
    Kalvista Pharmaceuticals
    11/13/17
  4955. 65
    Spirocyclic dihydro-thiazine and dihydro-oxazine BACE inhibitors, and compositions and uses thereof
    Imago Pharmaceuticals
    11/13/17
  4956. 59
    Substituted annulated triazines and use thereof
    Bayer Pharma Aktiengesellschaft
    11/13/17
  4957. 242
    Substituted bicyclic compounds
    Bristol-Myers Squibb
    11/13/17
  4958. 4
    Substituted imidazopyridazines
    Bayer Pharma Aktiengesellschaft
    11/13/17
  4959. 108
    Acyclic cyanoethylpyrazoles as janus kinase inhibitors
    Merck Sharp & Dohme
    11/06/17
  4960. 97
    C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use
    Merck Sharp & Dohme
    11/06/17
  4961. 223
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme
    11/06/17
  4962. 104
    Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disorders
    Takeda Pharmaceutical
    11/06/17
  4963. 113
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical
    11/06/17
  4964. 1
    Glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    11/06/17
  4965. 16
    Histone deacetylase inhibitors and compositions and methods of use thereof
    Chdi Foundation
    11/06/17
  4966. 174
    IRE-1α inhibitors
    Mannking
    11/06/17
  4967. 76
    Protein kinase B inhibitors
    Astrazeneca
    11/06/17
  4968. 18
    Rapamycin analogues and their pharmaceutical use
    Isomerase Therapeutics
    11/06/17
  4969. 11
    Syk inhibitors
    Gilead Sciences
    11/06/17
  4970. 44
    (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
    Oryzon Genomics
    10/30/17
  4971. 63
    3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme
    10/30/17
  4972. 246
    Bicyclically substituted uracils and the use thereof
    Bayer Pharma Aktiengesellschaft
    10/30/17
  4973. 128
    Complement pathway modulators and uses thereof
    Novartis
    10/30/17
  4974. 1
    Compound useful for the treatment of degenerative and inflammatory diseases
    Galapagos
    10/30/17
  4975. 29
    Inhibitors of matrix metalloproteinases
    Pharmahungary 2000
    10/30/17
  4976. 120
    Kinase inhibitors
    Respivert
    10/30/17
  4977. 2
    Matrix metalloproteinase inhibitors and methods for the treatment of pain and other diseases
    TBA
    10/30/17
  4978. 57
    Pyrazole carboxamide compounds and uses thereof
    Hoffmann-La Roche
    10/30/17
  4979. 130
    Substituted benzothienyl-pyrrolotriazines and uses thereof
    Bayer Intelletual Property
    10/30/17
  4980. 60
    Sulfonamide compound
    Mitsubishi Tanabe Pharma
    10/30/17
  4981. 1
    (Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT2A antagonists
    Eli Lilly
    10/23/17
  4982. 50
    2,4-pyrimidinediamine compounds and their uses
    Rigel Pharmaceuticals
    10/23/17
  4983. 14
    Boron containing small molecules
    Anacor Pharmaceuticals
    10/23/17
  4984. 23
    Fused pyrimidine compound, and preparation method, intermediate, composition, and uses thereof
    Shanghai Yingli Pharmaceutical
    10/23/17
  4985. 1
    Kinase inhibitor
    Respivert
    10/23/17
  4986. 21
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    10/23/17
  4987. 200
    Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
    Bristol-Myers Squibb
    10/23/17
  4988. 282
    Substituted 7-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    10/23/17
  4989. 220
    Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors
    Merck Sharp & Dohme
    10/23/17
  4990. 42
    Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
    Merck Sharp & Dohme
    10/23/17
  4991. 67
    Tricyclic pyrrolopyridine compound, and JAK inhibitor
    Nissan Chemical Industries
    10/23/17
  4992. 59
    (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
    Oryzon Genomics
    10/16/17
  4993. 36
    4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment
    Confluence Life Sciences
    10/16/17
  4994. 23
    Arylpyrrolopyridine derived compounds as LRRK2 inhibitors
    H. Lundbeck
    10/16/17
  4995. 78
    Benzazepine dicarboxamide compounds
    Hoffmann-La Roche
    10/16/17
  4996. 5
    Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
    Constellation Pharmaceuticals
    10/16/17
  4997. 31
    Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments
    Bayer Intellectual Property
    10/16/17
  4998. 130
    N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof
    Boehringer Ingelheim International
    10/16/17
  4999. 293
    P2X7 modulators
    Janssen Pharmaceutica
    10/16/17
  5000. 1
    Phenyl C-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
    Tianjin Institute Of Pharmaceutical Research
    10/16/17
  5001. 116
    Pyrrolidine derivatives and their use as complement pathway modulators
    Novartis
    10/16/17
  5002. 34
    Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
    Bristol-Myers Squibb
    10/16/17
  5003. 31
    Substituted benzoxazoles
    Bayer Pharma Aktiengesellschaft
    10/16/17
  5004. 37
    Biaryl ether sulfonamides and their use as therapeutic agents
    Xenon Pharmaceuticals
    10/10/17
  5005. 3
    4,5,6,7-tetrahyroimidazo[4,5-c]pyridine compounds
    Proximagen
    10/09/17
  5006. 22
    6-alkynyl-pyridine derivatives
    Boehringer Ingelheim International
    10/09/17
  5007. 44
    Apoptosis-inducing agent for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    10/09/17
  5008. 41
    Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors
    Chong Kun Dang Pharmaceutical
    10/09/17
  5009. 34
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    10/09/17
  5010. 125
    Melanocortin receptor-specific heptapeptides
    Palatin Technologies
    10/09/17
  5011. 568
    Pyrrolidinyl sulfone RORγ modulators
    Bristol-Myers Squibb
    10/09/17
  5012. 11
    Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
    Merck Sharp & Dohme
    10/09/17
  5013. 76
    Transient protection of normal cells during chemotherapy
    G1 Therapeutics
    10/09/17
  5014. 250
    Use of T1R3 venus flytrap region polypeptide to screen for taste modulators
    Senomyx
    10/09/17
  5015. 94
    Benzothiophene derivative
    Daiichi Sankyo
    10/02/17
  5016. 9
    Cyclic hydrocarbon compounds for the treatment of diseases
    Leo Pharma
    10/02/17
  5017. 8
    Imaging neuroinflammation
    Ge Healthcare
    10/02/17
  5018. 3
    Optically active PDE10 inhibitor
    Omeros
    10/02/17
  5019. 11
    Orvinol and thevinol derivatives useful in the treatment of anxiety or a compulsive disorder
    The University Of Bath
    10/02/17
  5020. 285
    Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
    Bristol-Myers Squibb
    10/02/17
  5021. 168
    Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives
    TBA
    10/02/17
  5022. 9
    Substituted benzoxazoles and methods of use thereof
    Genentech
    10/02/17
  5023. 184
    Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    10/02/17
  5024. 244
    Tetrahydroimidazo(1,5-D)[1,4]oxazepine derivative
    Eisai R&D Management
    10/02/17
  5025. 43
    Thrombin inhibitors
    Merck Sharp & Dohme
    10/02/17
  5026. 619
    6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use
    Abbvie
    09/25/17
  5027. 87
    Chemical entities
    FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii
    09/25/17
  5028. 31
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Euroscreen
    09/25/17
  5029. 21
    Complement factor B inhibitors and uses there of
    Novartis
    09/25/17
  5030. 130
    Complement pathway modulators and uses thereof
    Novartis
    09/25/17
  5031. 83
    Compounds
    Takeda Pharmaceutical
    09/25/17
  5032. 46
    Imidazopyrazines
    Bayer Intellectual Property
    09/25/17
  5033. 54
    Melanocortin-1 receptor-specific cyclic peptides
    Palatin Technologies
    09/25/17
  5034. 23
    Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
    Korea Institute Of Science And Technology
    09/25/17
  5035. 116
    Protein kinase C inhibitors and methods of their use
    Novartis
    09/25/17
  5036. 1
    Quinoline inhibitor of the macrophage stimulating 1 receptor MSTR1
    Merck Patent
    09/25/17
  5037. 55
    Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    09/25/17
  5038. 16
    Substituted oxopyridine derivatives and use thereof as factor xia/plasma
    Bayer Pharma Aktiengesellschaft
    09/25/17
  5039. 1
    (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
    Gilead Sciences
    09/18/17
  5040. 98
    Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient
    Ahn-Gook Pharmaceutical
    09/18/17
  5041. 88
    Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders
    University Of Utah Research Foundation
    09/18/17
  5042. 7
    Inhibitors of Bruton's tyrosine kinase
    Hoffmann-La Roche
    09/18/17
  5043. 7
    Naphthylurea derivatives and medical applications thereof
    Radiant Pharma & Tech.
    09/18/17
  5044. 3
    Phenyloxadiazole derivatives as PGDS inhibitors
    Sanofi
    09/18/17
  5045. 66
    Pyrimidine FGFR4 inhibitors
    Eisai R&D Management
    09/18/17
  5046. 12
    Spirocyclic sulfones as gamma secretase inhibitors
    Merck Sharp & Dohme
    09/18/17
  5047. 112
    Substituted 4-phenylpiperidines, their preparation and use
    Columbia University
    09/18/17
  5048. 203
    Substituted B-amino acid derivatives as CXCR3 receptor antagonists
    Sanofi
    09/18/17
  5049. 321
    Substituted benzamides
    Hoffmann-La Roche
    09/18/17
  5050. 217
    Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
    Beigene
    09/18/17
  5051. 107
    Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
    Takeda Pharmaceutical
    09/18/17
  5052. 19
    2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    09/11/17
  5053. 199
    5-azaindazole compounds and methods of use
    F. Hoffmann-La Roche
    09/11/17
  5054. 42
    Benzimidazole derivatives as bromodomain inhibitors
    Gilead Sciences
    09/11/17
  5055. 36
    C2-azaspiro iminothiazine dioxides as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    09/11/17
  5056. 1
    Crystalline forms and processes for the preparation of cannabinoid receptor modulators
    Arena Pharmaceuticals
    09/11/17
  5057. 30
    Dihydroquinoline-2-one derivatives
    Hoffmann-La Roche
    09/11/17
  5058. 6
    Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators
    Temple University
    09/11/17
  5059. 29
    Furanone compounds as kinase inhibitors
    Eternity Bioscience
    09/11/17
  5060. 34
    Glucokinase activator compounds, compositions containing such compounds, and methods of treatment
    Merck Sharp & Dohme
    09/11/17
  5061. 17
    IAP antagonists
    Bristol-Myers Squibb
    09/11/17
  5062. 10
    Inhibitors of Bruton's tyrosine kinase
    Hoffmann-La Roche
    09/11/17
  5063. 4
    Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
    Acetylon Pharmaceuticals
    09/11/17
  5064. 23
    Pyrrolidine derivatives and their use as complement pathway modulators
    Novartis
    09/11/17
  5065. 701
    Sulfonamides as TRPM8 modulators
    Janssen Pharmaceutica
    09/11/17
  5066. 43
    Trk-inhibiting compound
    Ono Pharmaceutical
    09/11/17
  5067. 471
    3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
    Novartis
    09/05/17
  5068. 3
    Antiviral therapies with phospholipase D inhibitors
    Vanderbilt University
    09/05/17
  5069. 28
    Fluorinated arylalkylaminocarboxamide derivatives
    Newron Pharmaceuticals
    09/05/17
  5070. 34
    Imidazopyridine compounds
    Astellas Pharma
    09/05/17
  5071. 17
    Iminothiadiazine dioxides containing a thioamide, amidine, or amide oxime group as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    09/05/17
  5072. 1
    Ocular formulations for drug-delivery to the posterior segment of the eye
    Panoptica
    09/05/17
  5073. 71
    PDE9 inhibitors with imidazo triazinone backbone
    H. Lundbeck
    09/05/17
  5074. 5
    Pharmaceutically active compounds
    Cancer Research Technology
    09/05/17
  5075. 40
    Protein kinase inhibitors
    Orion
    09/05/17
  5076. 30
    Pyrimidine derivatives as phosphodiesterase 10 inhibitors (PDE-10)
    Palobiofarma
    09/05/17
  5077. 8
    Pyrimidinones as factor XIa inhibitors
    Bristol-Myers Squibb
    09/05/17
  5078. 17
    Pyrimidodiazepinone compound
    Kyowa Hakko Kirin
    09/05/17
  5079. 84
    Quinuclidines for modulating alpha 7 activity
    Alpharmagen
    09/05/17
  5080. 39
    Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
    Sanofi
    09/05/17
  5081. 8
    Tau imaging probe
    Ge Healthcare
    09/05/17
  5082. 161
    2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
    Centaurus Biopharma
    08/28/17
  5083. 25
    BTK inhibitors
    Merck Sharp & Dohme
    08/28/17
  5084. 20
    Benzimidazole-imidazole derivatives
    Janssen Ireland
    08/28/17
  5085. 104
    Bromodomain inhibitors
    Abbvie
    08/28/17
  5086. 65
    DYRK1 inhibitors and uses thereof
    Diaxonhit
    08/28/17
  5087. 2
    Highly active nucleoside derivative for the treatment of HCV
    Achillion Pharmaceuticals
    08/28/17
  5088. 79
    Imidazo[4,5-c]quinolin-2-one compounds and their use in treating Cancer
    Astrazeneca
    08/28/17
  5089. 73
    Imidazopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
    Bristol-Myers Squibb
    08/28/17
  5090. 4
    Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    08/28/17
  5091. 165
    Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms
    Case Western Reserve University
    08/28/17
  5092. 29
    Schiff bases of thiazoles: a new class of ureases inhibitors
    TBA
    08/28/17
  5093. 143
    Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
    Bayer Pharma Aktiengesellschaft
    08/28/17
  5094. 45
    Substituted pyrazoles as N-type calcium channel blockers
    Janssen Pharmaceutica
    08/28/17
  5095. 23
    Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives
    Hydra Biosciences
    08/28/17
  5096. 29
    Triazolopyrazine
    Boehringer Ingelheim International
    08/28/17
  5097. 17
    Hydantoin derivative
    Chugai Seiyaku Kabushiki Kaisha
    08/24/17
  5098. 29
    Antiviral compounds
    F. Hoffmann-La Roche
    08/22/17
  5099. 2
    α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
    Merck Serono
    08/21/17
  5100. 498
    1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives
    Actelion Pharmaceuticals
    08/21/17
  5101. 169
    7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor
    Bristol-Myers Squibb
    08/21/17
  5102. 57
    Alpha-carbolines for the treatment of cancer
    Universita Degli Studi Di Milano—Bicocca
    08/21/17
  5103. 20
    Benzimidazole-imidazole derivatives
    Janssen Ireland
    08/21/17
  5104. 19
    Bicyclic nitrogen-containing aromatic heterocyclic amide compound
    Astellas Pharma
    08/21/17
  5105. 9
    Combination therapy for treating cancer
    Epizyme
    08/21/17
  5106. 335
    Heterocyclic modulators of lipid synthesis
    3-V Biosciences
    08/21/17
  5107. 27
    Macrocyclic indole derivatives useful as hepatitis C virus inhibitors
    Janssen Ireland
    08/21/17
  5108. 32
    N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products
    Bayer Pharma Aktiengesellschaft
    08/21/17
  5109. 41
    Piperazine derivatives, compositions, and uses related thereto
    Emory University
    08/21/17
  5110. 9
    S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    08/21/17
  5111. 24
    Secondary alcohol substituted triazoles as PDE10 inhibitors
    Merck Sharp & Dohme
    08/21/17
  5112. 10
    Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof
    TBA
    08/21/17
  5113. 377
    Tetrahydro-pyrimidoazepines as modulators of TRPV1
    Janssen Pharmaceutica
    08/21/17
  5114. 54
    2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer
    Hoffmann-La Roche
    08/14/17
  5115. 47
    Azaheterocycles as BIR2 and/or BIR3 inhibitors
    Hoffmann-La Roche
    08/14/17
  5116. 21
    Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer
    The Royal Institution For The Advancement Of Learning/Mcgill University
    08/14/17
  5117. 223
    Cyclic amines
    H. Lundbeck
    08/14/17
  5118. 35
    Epoxyeicosatrienoic acid analogs and methods of making and using the same
    The Medical College Of Wisconsin
    08/14/17
  5119. 29
    Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds
    Bristol-Myers Squibb
    08/14/17
  5120. 51
    Partially saturated nitrogen-containing heterocyclic compound
    Taisho Pharmaceutical
    08/14/17
  5121. 20
    S-imino-S-oxo-iminothiazine compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    08/14/17
  5122. 46
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Euroscreen
    08/14/17
  5123. 103
    Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
    Tolero Pharmaceuticals
    08/14/17
  5124. 95
    Sulfonamide derivatives with therapeutic indications
    Pharmos
    08/14/17
  5125. 36
    Triazolopyridazine
    Boehringer Ingelheim International
    08/14/17
  5126. 27
    Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
    Duquesne University Of The Holy Ghost
    08/14/17
  5127. 120
    Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
    Merck Sharp & Dohme
    08/14/17
  5128. 83
    Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
    Merck Sharp & Dohme
    08/14/17
  5129. 30
    2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
    Gilead Pharmasset
    08/07/17
  5130. 183
    4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
    Fibrogen
    08/07/17
  5131. 44
    5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    08/07/17
  5132. 15
    Acid ceramidase inhibitors and their use as medicaments
    Fondazione Istituto Italiano Di Technologia
    08/07/17
  5133. 69
    Autotaxin inhibitors
    Novartis
    08/07/17
  5134. 216
    Dihydropyridone p1 as factor XIa inhibitors
    Bristol-Myers Squibb
    08/07/17
  5135. 27
    Dimeric compounds
    Hoffmann-La Roche
    08/07/17
  5136. 4
    HCV protease inhibitors and uses thereof
    Celgene Avilomics Research
    08/07/17
  5137. 86
    Heterocyclic amide derivatives as P2X7 receptor antagonists
    Actelion Pharmaceuticals
    08/07/17
  5138. 36
    Imidamide sphingosine kinase inhibitors
    University Of Virginia Patent Foundation
    08/07/17
  5139. 204
    Inhibitor compounds
    Cancer Research Technology
    08/07/17
  5140. 16
    Kinase modulators for the treatment of cancer
    Synovo
    08/07/17
  5141. 5
    Methods for reducing uric acid levels using barbiturate derivatives
    TBA
    08/07/17
  5142. 34
    Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof
    Sunshine Lake Pharma
    08/07/17
  5143. 90
    Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
    Janssen Pharmaceutica
    08/07/17
  5144. 17
    2,4,7-substituted thieno[3,2-d]pyrimidine compounds as protein kinase inhibitors
    Korea Institute Of Science And Technology
    08/01/17
  5145. 4
    6-substituted demethyl-estradiol derivatives as selective ER-β agonists
    Endece
    08/01/17
  5146. 21
    Azabenzimidazole derivatives
    Boehringer Ingelheim International
    08/01/17
  5147. 5
    Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
    Allergan
    08/01/17
  5148. 19
    3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
    Nerviano Medical Sciences
    07/31/17
  5149. 135
    Azetidine amide derivatives as orexin receptor antagonists
    Actelion Pharmaceuticals
    07/31/17
  5150. 54
    Cysteine protease inhibitors and uses thereof
    The Trustees Of Columbia University In The City Of New York
    07/31/17
  5151. 10
    Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof
    Bayer Pharma Aktiengesellschaft
    07/31/17
  5152. 11
    Heterocyclic resorcinol derivatives, preparation of same and cosmetic uses thereof
    Pierre Fabre Dermo-Cosmetique
    07/31/17
  5153. 5
    Method for inhibiting Trypanosoma cruzi
    Howard University
    07/31/17
  5154. 105
    Pyrazine derivatives
    Hoffmann-La Roche
    07/31/17
  5155. 48
    Pyridine derivatives
    Hoffmann-La Roche
    07/31/17
  5156. 222
    Pyridine-2-amides useful as CB2 agonists
    Hoffmann-La Roche
    07/31/17
  5157. 19
    Selective glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    07/31/17
  5158. 71
    Substituted 4-aminocyclohexane derivatives
    Gruenenthal
    07/31/17
  5159. 40
    Substituted heteroaryl compounds and methods of use
    Calitor Sciences
    07/31/17
  5160. 170
    Substituted phenylimidazopyrazoles and their use
    Bayer Pharma Aktiengesellschaft
    07/31/17
  5161. 32
    Triazole carboxamides and uses thereof
    Hoffmann-La Roche
    07/31/17
  5162. 134
    Triazolo compounds as PDE10 inhibitors
    Hoffmann-La Roche
    07/31/17
  5163. 48
    Carboxamide derivatives
    Novartis
    07/25/17
  5164. 4
    3-O-acyl-ingenol analogues
    Leo Laboratories
    07/24/17
  5165. 13
    5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    07/24/17
  5166. 22
    Alpha-(3,5-dimethoxybenzylidene)-alpha′-hydrocarbyl methylene cyclic ketone and preparation method thereof
    Pharmaxyn Laboratories
    07/24/17
  5167. 430
    Amides as pim inhibitors
    Amgen
    07/24/17
  5168. 25
    Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    07/24/17
  5169. 16
    Carboxamide derivatives
    Novartis
    07/24/17
  5170. 4
    Compound for increasing kinase active and application thereof
    Fujian Haixi Pharmaceuticals
    07/24/17
  5171. 366
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme
    07/24/17
  5172. 10
    Indole-3-carboxamides as kinase inhibitors
    Allergan
    07/24/17
  5173. 12
    Indolines
    Hoffmann-La Roche
    07/24/17
  5174. 22
    Inhibitors of rho associated protein kinases (ROCK) and methods of use
    H. Lee Moffin Cancer Center And Research Institute
    07/24/17
  5175. 19
    Selective histone deactylase 6 inhibitors
    H. Lee Moffitt Cancer Center And Research Institute
    07/24/17
  5176. 37
    Substituted indazole derivatives active as kinase inhibitors
    Nerviano Medical Sciences
    07/24/17
  5177. 25
    Substituted purinone compounds
    Novartis
    07/24/17
  5178. 41
    Triazolopyrazine derivative and use thereof
    Korea Research Institute Of Chemical Technology
    07/24/17
  5179. 11
    Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases
    University Of Arkansas
    07/24/17
  5180. 93
    Diamide compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
    Theravance Respiratory
    07/18/17
  5181. 16
    Therapeutic prostaglandin receptor agonists
    Allergan
    07/18/17
  5182. 2
    5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use
    Cancer Research Technology
    07/17/17
  5183. 10
    Benzoxazinone amides as mineralocorticoid receptor modulators
    Astrazeneca
    07/17/17
  5184. 6
    Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
    Bristol-Myers Squibb
    07/17/17
  5185. 177
    Indole and indazole compounds that activate AMPK
    Pfizer
    07/17/17
  5186. 44
    Inhibitors of c-fms kinase
    Janssen Pharmaceutica
    07/17/17
  5187. 10
    Inhibitors of c-fms kinase
    Janssen Pharmaceutica
    07/17/17
  5188. 9
    Isoquinoline-5-carboxamide derivative having inhibitory activity for protein kinase
    Hanmi Pharm.
    07/17/17
  5189. 20
    Method for the treatment of neurological disorders by enhancing the activity of β-glucocerebrosidase
    Amicus Therapeutics
    07/17/17
  5190. 5
    Mutant-selective EGFR inhibitors and uses thereof
    Celgene Avilomics Research
    07/17/17
  5191. 13
    Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
    Washington University
    07/17/17
  5192. 196
    Pyrazole carboxamides as Janus kinase inhibitors
    Merck Sharp & Dohme
    07/17/17
  5193. 46
    Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
    Universitaet Des Saarlandes Campus Saarbruecken
    07/17/17
  5194. 23
    Small molecule inhibitors of MCL-1 and uses thereof
    The Regents Of The University Of Michigan
    07/17/17
  5195. 122
    Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones
    Beigene
    07/17/17
  5196. 131
    Substituted hetero-azepinones
    F. Hoffmann-La Roche
    07/17/17
  5197. 19
    Substituted pyrrolidines as factor xia inhibitors for the treatment thromboembolic diseases
    Ono Pharmaceutical
    07/17/17
  5198. 12
    Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
    Purdue Research Foundation
    07/17/17
  5199. 6
    TRPV1 antagonists including dihydroxy substituent and uses thereof
    Purdue Pharma
    07/17/17
  5200. 4
    Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase
    The University Of Denver And Regis University
    07/10/17
  5201. 5
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    07/10/17
  5202. 37
    C5, C6 oxacyclic-fused thiazine dioxide compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    07/10/17
  5203. 2
    Depsipeptide and uses thereof
    Novobiotic Pharmaceuticals
    07/10/17
  5204. 28
    Derivatives of celeboxib, use thereof and preparation thereof
    German University
    07/10/17
  5205. 25
    Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
    Galderma Research & Development
    07/10/17
  5206. 5
    Fused heteroaryl pyridyl and phenyl benzenesuflonamides as CCR2 modulators for the treatment of inflammation
    Chemocentryx
    07/10/17
  5207. 75
    Heterocyclic amide derivatives as P2X7 receptor antagonists
    Actelion Pharmaceuticals
    07/10/17
  5208. 16
    Heterocyclic amide derivatives as P2X7 receptor antagonists
    Actelion Pharmaceuticals
    07/10/17
  5209. 18
    Imidazopyridine derivatives
    Hoffmann-La Roche
    07/10/17
  5210. 12
    Macrocyclic inhibitors of hepatitis C virus
    Janssen Ireland
    07/10/17
  5211. 87
    Method of treating conditiions with kinase inhibitors
    Allergan
    07/10/17
  5212. 6
    PI3K and/or mTOR inhibitor
    Xuanzhu Pharma
    07/10/17
  5213. 2
    Pyrimidinyl-pyridazinone derivatives for treating a disease which is influenced by inhibition of met kinase
    Merck Patent
    07/10/17
  5214. 44
    Pyrrolidine derivatives and their use as complement pathway modulators
    Novartis
    07/10/17
  5215. 81
    Pyrrolotriazinone derivatives as PI3K inhibitors
    Almirall
    07/10/17
  5216. 14
    Serine/threonine kinase inhibitors
    Genetech
    07/10/17
  5217. 16
    Substituted 1,2,3,4-tetrahydro-2,6-naphthyridines as factor XIa inhibitors
    Bristol-Myers Squibb
    07/10/17
  5218. 7
    Substituted 1,2,3,4-tetrahydropyrido[3,4-E] pyrrolo[1,2-A]pyrimidines as kinase
    Allergan
    07/10/17
  5219. 117
    Substituted benzimidazoles
    Bayer Intellectual Property
    07/10/17
  5220. 60
    Substituted morphinans and the use thereof
    Purdue Pharma
    07/10/17
  5221. 19
    Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
    Chroma Therapeutics
    07/10/17
  5222. 22
    Thyroid hormone analogs
    Hoffmann-La Roche
    07/10/17
  5223. 126
    1,3 substituted azetidine PDE10 inhibitors
    Merck Sharp & Dohme
    07/03/17
  5224. 15
    3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
    Johannes Gutenberg-UniversitäT Mainz
    07/03/17
  5225. 13
    Aroyl thiourea derivatives
    University Court Of The University Of St Andrews
    07/03/17
  5226. 19
    Arylated camphenes, processes for their preparation and uses thereof
    Yissum Research Development Company Of The Hebrew University Of Jerusalem
    07/03/17
  5227. 20
    Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
    Galderma Research & Devlopment
    07/03/17
  5228. 34
    Bicyclic substituted pyrimidine compounds
    Xuanzhu Pharma
    07/03/17
  5229. 26
    Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders
    Arena Pharmaceuticals
    07/03/17
  5230. 29
    Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    07/03/17
  5231. 20
    Immune system modulators
    Janus Biotherapeutics
    07/03/17
  5232. 25
    Kinase inhibitors
    Allergan
    07/03/17
  5233. 7
    Matriptase inhibitors and uses thereof against orthomyxoviridae infections
    TBA
    07/03/17
  5234. 18
    Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
    Washington University
    07/03/17
  5235. 11
    Prolylcarboxypeptidase inhibitors
    Merck Sharp & Dohme
    07/03/17
  5236. 238
    Pyrrolopyrrolidinone compounds
    Novartis
    07/03/17
  5237. 8
    Quaternized amines as sodium channel blockers
    Purdue Pharma
    07/03/17
  5238. 1
    Salt form of a human histone methyltransferase EZH2 inhibitor
    Epizyme
    07/03/17
  5239. 67
    Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    07/03/17
  5240. 5
    Substituted heteroaryl compounds and methods of use
    Calitor Sciences
    07/03/17
  5241. 2
    Substituted pyridinone-pyridinyl compounds
    Confluence Life Sciences
    07/03/17
  5242. 36
    Synthetic peptide amides
    Cara Therapeutics
    07/03/17
  5243. 137
    TRPV1 antagonists including dihydroxy substituent and uses thereof
    Purdue Pharma
    07/03/17
  5244. 240
    Cyclopropanecarboxamido-substitute aromatic compounds as anti-tumor agents
    Crown Bioscience Inc. (Taiwan
    06/27/17
  5245. 2
    Quinazoline derivatives as kinases inhibitors and methods of use thereof
    Teligene
    06/27/17
  5246. 3
    Substituted aminoquinazolines useful as kinases inhibitors
    TBA
    06/27/17
  5247. 49
    2-amino 3,5,5-trifluoro-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treatment of Alzheimer's disease
    H. Lundbeck
    06/26/17
  5248. 12
    Acetamide derivatives
    Hoffmann-La Roche
    06/26/17
  5249. 2
    Aldehyde derivative of substitute oxazolidinones
    Wanbury
    06/26/17
  5250. 82
    Compositions and methods for the treatment of malaria
    Saint Louis University
    06/26/17
  5251. 64
    Cyclic amine substituted heterocyclic CETP inhibitors
    Merck Sharp & Dohme
    06/26/17
  5252. 11
    Cyclopropyl imidazopyridine PDE10 inhibitors
    Merck Sharp & Dohme
    06/26/17
  5253. 94
    Dihydropyridinone MGAT2 inhibitors
    Bristol-Myers Squibb
    06/26/17
  5254. 19
    Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
    Merck Sharp & Dohme
    06/26/17
  5255. 26
    Indole-1-carboxamides as kinase inhibitors
    Allergan
    06/26/17
  5256. 27
    Methods and compositions for kinase inhibition
    The Regents Of The University Of California
    06/26/17
  5257. 42
    Non-annulated thiophenylamides
    Hoffmann-La Roche
    06/26/17
  5258. 130
    Substituted pyridizinone derivatives as PDE10 inhibitors
    Merck Sharp & Dohme
    06/26/17
  5259. 12
    Thiazole derivatives as inhibitors of Bruton's tyrosine kinase
    Hoffmann-La Roche
    06/26/17
  5260. 64
    Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
    Vtv Therapeutics
    06/26/17
  5261. 7
    3,5,N-trihydroxy-alkanamide and derivatives: method for making same and use thereof
    National Taiwan University
    06/19/17
  5262. 29
    5-HT3 receptor antagonists
    Takeda Pharmaceutical
    06/19/17
  5263. 46
    Bicyclic dihydroquinoline-2-one derivatives
    Hoffmann-La Roche
    06/19/17
  5264. 55
    Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA)
    University Of California
    06/19/17
  5265. 6
    Ethynyl derivatives
    Hoffmann-La Roche
    06/19/17
  5266. 49
    FAP inhibitors
    Universiteit Antwerp
    06/19/17
  5267. 33
    Heterocyclic carboxylic acid ester derivative
    Ajinomoto
    06/19/17
  5268. 323
    Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
    Boehringer Ingelheim International
    06/19/17
  5269. 123
    Indazole derivatives useful as ERK inhibitors
    Merck Sharp & Dohme
    06/19/17
  5270. 4
    Methods of treatment using modulators of SIRT2
    Cornell University
    06/19/17
  5271. 122
    Pyrrolidine compounds
    Hoffmann-La Roche
    06/19/17
  5272. 225
    Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors
    Merck Sharp & Dohme
    06/19/17
  5273. 23
    Substituted piperidines as sodium channel blockers
    Purdue Pharma
    06/19/17
  5274. 465
    5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof
    Genentech
    06/12/17
  5275. 42
    Aminostatin derivatives for the treatment of arthrosis
    Merck Patent
    06/12/17
  5276. 10
    Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses
    Zhejiang Hisun Pharmaceutical
    06/12/17
  5277. 3
    Heterocyclic compounds and uses thereof in the treatment of sexual disorders
    Atir Holding
    06/12/17
  5278. 11
    Immune system modulators
    Janus Biotherapeutics
    06/12/17
  5279. 2
    Oxazetidine derivatives, process for preparing them and use in human medicine and in cosmetics
    Galderma Research & Development
    06/12/17
  5280. 7
    Pharmaceutical uses of 6-amino quinazoline or 3-cyano quinoline derivatives
    Jiangsu Hengrui Medicine
    06/12/17
  5281. 9
    Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
    University Of Kansas
    06/12/17
  5282. 9
    Pyrazolopyridyl compounds as aldosterone synthase inhibitors
    Merck Sharp & Dohme
    06/12/17
  5283. 64
    Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    06/12/17
  5284. 93
    Substituted sulfonamides useful as antiapoptotic Bcl inhibitors
    Bristol-Myers Squibb
    06/12/17
  5285. 13
    Tetrahydrocarboline derivative
    Ono Pharmaceutical
    06/12/17
  5286. 10
    5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
    Amgen
    06/05/17
  5287. 16
    Alkyl linked quinolinyl modulators of RORγt
    Janssen Pharmaceutica
    06/05/17
  5288. 39
    Benzodioxole derivative and preparation method and use thereof
    Zhejiang Hisun Pharmaceutical
    06/05/17
  5289. 53
    Compositions and methods useful for treating diseases
    Eutropics Pharmaceuticals
    06/05/17
  5290. 258
    Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
    Amgen
    06/05/17
  5291. 11
    Indomethacin analogs for the treatment of castrate-resistant prostate cancer
    Vanderbilt University
    06/05/17
  5292. 3
    Inhibitors of protein tyrosine phosphatases
    Indiana University Research And Technology
    06/05/17
  5293. 178
    Oxazolidinone compounds and derivatives thereof
    Amgen
    06/05/17
  5294. 14
    Piperidine compound or salt thereof
    Taiho Pharmaceutical
    06/05/17
  5295. 50
    17a-hydroxylase/C17,20-lyase inhibitors
    Novartis
    05/31/17
  5296. 12
    2-amino 6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
    H. Lundbeck
    05/31/17
  5297. 129
    Aromatic heterocyclic derivative having TRPV4-inhibiting activity
    Shionogi
    05/31/17
  5298. 102
    Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
    Novatis
    05/31/17
  5299. 327
    Carboxamides as inhibitors of voltage-gated sodium channels
    Amgen
    05/31/17
  5300. 15
    Hydroxylated aminotriazole derivatives as ALX receptor agonists
    Actelion Pharmaceuticals
    05/31/17
  5301. 489
    Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor
    Mimetica
    05/31/17
  5302. 107
    Pharmacologically active compounds
    Cancer Research Technology
    05/31/17
  5303. 76
    Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists
    Merck Sharp & Dohme
    05/31/17
  5304. 109
    Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    05/31/17
  5305. 2
    Substituted quinolines as bruton's tyrosine kinases inhibitors
    Hangzhouderenyucheng Biotechnology
    05/31/17
  5306. 60
    Substituted tetrahydrocarbazole and carbazole carboxamide compounds
    Bristol-Myers Squibb
    05/31/17
  5307. 245
    Tetrahydroisoquinoline derivatives, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    05/31/17
  5308. 2
    Thienopyrimidine compounds and use thereof
    Takeda Pharmaceutical
    05/31/17
  5309. 34
    Acetamide derivatives as glucokinase activators, their process and medicinal applications
    Advinus Therapeutics
    05/22/17
  5310. 14
    Azaindolines
    Hoffmann-La Roche
    05/22/17
  5311. 69
    Compounds as tyrosine kinase modulators
    Allergan
    05/22/17
  5312. 20
    Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi
    Piramal Imaging
    05/22/17
  5313. 65
    Hepatitis C virus inhibitors
    Bristol-Myers Squibb
    05/22/17
  5314. 12
    IAP antagonists
    Bristol-Myers Squibb
    05/22/17
  5315. 65
    Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
    Green Cross
    05/22/17
  5316. 7
    Propellane-based compounds and the use thereof
    Purdue Pharma
    05/22/17
  5317. 6
    Pyridine and piperidine derivatives as novel sodium channel blockers
    Purdue Pharma
    05/22/17
  5318. 144
    Pyrrolopyrimidine compounds and uses thereof
    Hutchison Medipharma
    05/22/17
  5319. 9
    Selective β-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents
    University Of North Carolina At Chapel Hill
    05/22/17
  5320. 5
    Specific inhibitors and active site probes for legumain
    The Board Of Trustees Of The Leland Stanford Junior University
    05/22/17
  5321. 661
    Cyanomethylpyrazole carboxamides as janus kinase inhibitors
    Merck Sharp & Dohme
    05/18/17
  5322. 34
    Quinuclidine derivatives and medicinal compositions containing the same
    Almirall
    05/18/17
  5323. 13
    4-amino-imidazoquinoline compounds
    Hoffman-La Roche
    05/15/17
  5324. 1
    Compounds and methods for treating ocular diseases
    Allergan
    05/15/17
  5325. 284
    Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
    Genentech
    05/15/17
  5326. 4
    Heterocyclic modulators of cannabinoid receptors
    The Cleveland Clinic Foundation
    05/15/17
  5327. 2
    Inhibitors of human EZH2, and methods of use thereof
    Epizyme
    05/15/17
  5328. 3
    Isoxazolo-quinazolines as modulators of protein kinase activity
    Nerviano Medical Sciences
    05/15/17
  5329. 7
    Methods of treatment of histamine H-4 receptor-related pruritus associated with nerve disorders
    Bridge Pharma
    05/15/17
  5330. 7
    Process for making isoquinoline compounds
    Fibrogen
    05/15/17
  5331. 32
    Purine derivatives and their use in the treatment of disease
    Novarits
    05/15/17
  5332. 119
    Pyrimidinone derivatives as antimalarial agents
    Sanofi
    05/15/17
  5333. 38
    Pyrrolo[2,3-B]pyrazines as SYK inhibitors
    Hoffmann-La Roche
    05/15/17
  5334. 794
    Tropomyosin-related kinase inhibitors
    Pfizer
    05/15/17
  5335. 28
    6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
    Boehringer Ingelheim International
    05/08/17
  5336. 46
    8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
    Boehringer Ingelheim International
    05/08/17
  5337. 5
    A3 adenosine receptor allosteric modulators
    The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services
    05/08/17
  5338. 242
    Aminopyrimidine derivatives for use as modulators of kinase activity
    Merck Patent
    05/08/17
  5339. 9
    Apoptosis signal-regulating kinase inhibitor
    Gilead Sciences
    05/08/17
  5340. 293
    Azole compounds as PIM inhibitors
    Amgen
    05/08/17
  5341. 3
    BACE inhibitors
    Eli Lilly
    05/08/17
  5342. 7
    Compounds
    Respivert
    05/08/17
  5343. 5
    Ethynyl derivatives
    Hoffmann-La Roche
    05/08/17
  5344. 123
    Nitrogen-containing bicyclic aromatic heterocyclic compound
    Astellas Pharma
    05/08/17
  5345. 4
    Rotenone derivatives and a use thereof
    Korea Atomic Energy Research Institute
    05/08/17
  5346. 18
    Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors
    Beigene
    05/08/17
  5347. 193
    Tetracyclic CDK9 kinase inhibitors
    Abbvie
    05/03/17
  5348. 115
    2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
    Pfizer
    05/01/17
  5349. 30
    Aminopyridine derived compounds as LRRK2 inhibitors
    H. Lundbeck
    05/01/17
  5350. 33
    Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient
    Korea Research Institute Of Chemical Technology
    05/01/17
  5351. 7
    Compositions and methods for treating neoplasia, inflammatory disease and other disorders
    Dana-Farber Cancer Institute
    05/01/17
  5352. 25
    Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase
    University Of California
    05/01/17
  5353. 5
    Kinase inhibitors
    Allergan
    05/01/17
  5354. 14
    N-alkyltriazole compounds as LPAR antagonists
    Hoffman-La Roche
    05/01/17
  5355. 10
    Pyrazole derivative
    Green Tech
    05/01/17
  5356. 5
    ROR modulators and their uses
    Innov17
    05/01/17
  5357. 55
    Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods
    Indiana University Research And Technology
    05/01/17
  5358. 44
    Small molecule inhibitors of the pleckstrin homology domain and methods for using same
    The University Of Texas System
    05/01/17
  5359. 64
    Compounds and uses
    Astrazeneca
    04/27/17
  5360. 20
    1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
    Incyte
    04/24/17
  5361. 9
    1,3-dioxanomorphides and 1,3-dioxanocodides
    Rhodes Technologies
    04/24/17
  5362. 7
    Acid addition salt of substituted pyridine compound
    Daiichi Sankyo
    04/24/17
  5363. 173
    Arlethynyl derivatives
    Hoffman-La Roche
    04/24/17
  5364. 26
    Bicyclic heteroaryl cycloalkyldiamine derivatives
    Novartis
    04/24/17
  5365. 80
    Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
    Novartis
    04/24/17
  5366. 41
    Cytomegalovirus inhibitor compounds
    Boehringer Ingelheim International
    04/24/17
  5367. 6
    Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
    Bristol-Myers Squibb
    04/24/17
  5368. 25
    Imidazopyridin-2-one derivatives
    Merck Sharp & Dohme
    04/24/17
  5369. 7
    Kinase inhibitors
    Allergan
    04/24/17
  5370. 18
    Phenylpyridine derivative and drug containing same
    Kowa
    04/24/17
  5371. 129
    Pyrimidine compounds as mTOR and PI3K inhibitors
    Development Center For Biotechnology
    04/24/17
  5372. 32
    Substituted imidazopyridazines
    Bayer Intellectual Property
    04/24/17
  5373. 3
    Treating diabetes with dipeptidyl peptidase-IV inhibitors
    Merck Sharp & Dohme
    04/24/17
  5374. 12
    2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
    Georgetown University
    04/10/17
  5375. 153
    5-HT3 receptor antagonists
    Takeda Pharmaceutical
    04/10/17
  5376. 404
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    04/10/17
  5377. 122
    Chemokine receptor modulators
    Altiris Therapeutics
    04/10/17
  5378. 22
    Compounds and compositions as protein kinase inhibitors
    Novartis
    04/10/17
  5379. 15
    Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities
    Almirall
    04/10/17
  5380. 44
    Heteroaryl linked quinolinyl modulators of RORγt
    Janssen Pharmaceutica
    04/10/17
  5381. 19
    Heterocyclic group contained amino-methanol derivative, and salt, synthetic method and use thereof
    Beijing Foreland Biopharma
    04/10/17
  5382. 5
    Optically pure benzyl-4-chlorophenyl-C-glucoside derivative
    Xuanzhu Pharma
    04/10/17
  5383. 145
    Pyrazole and imidazole derivatives useful as orexin antagonists
    Actelion Pharmaceuticals
    04/10/17
  5384. 152
    Pyridine-2-amides useful as CB2 agonists
    Hoffman-La Roche
    04/10/17
  5385. 34
    Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel
    Novartis
    04/10/17
  5386. 16
    Nicotinic receptor compounds
    Research Triangle Institute
    04/04/17
  5387. 93
    Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
    Amgen
    04/03/17
  5388. 39
    Azetidine-substituted quinoxalines as opioid receptor like-1 modulators
    Purdue Pharma
    04/03/17
  5389. 27
    Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof
    University Of Pennsylvania
    04/03/17
  5390. 348
    Bromodomain inhibitors
    Abbvie
    04/03/17
  5391. 17
    Chimeric small molecules for the recruitment of antibodies to cancer cells
    Yale University
    04/03/17
  5392. 145
    Continuous arycyclic compound
    Mitsubishi Tanabe Pharma
    04/03/17
  5393. 25
    Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
    Pharmacyclics
    04/03/17
  5394. 94
    Methylene linked quinolinyl modulators of RORγt
    Janssen Pharmaceutica
    04/03/17
  5395. 27
    Selective inhibitors of human corticosteroid synthases
    Universitat Des Saarlandes
    04/03/17
  5396. 10
    Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
    Bayer Intellectual Property
    04/03/17
  5397. 26
    Substituted 3-haloallylamine inhibitors of ASSAO and uses thereof
    Boehringer Ingelheim International
    04/03/17
  5398. 1176
    Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
    Senhwa Biosciences
    03/30/17
  5399. 17
    Benzyl sulfonamide derivatives as RORc modulators
    Genentech
    03/21/17
  5400. 650
    Bicyclic sulfonamide compounds as sodium channel inhibitors
    Amgen
    03/21/17
  5401. 12
    Cycloalkylmethylamines
    Reviva Pharmaceuticals
    03/21/17
  5402. 2
    D3 dopamine receptor agonists to treat dyskinesia in parkinson's disease
    Drexel University
    03/21/17
  5403. 363
    Fused pyrroledicarboxamides and their use as pharmaceuticals
    Sanofi
    03/21/17
  5404. 50
    HDAC inhibitors and therapeutic methods using the same
    University Of Illinois
    03/21/17
  5405. 10
    Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
    Albert Einstein College Of Medicine
    03/21/17
  5406. 89
    Substituted benzothienopyrimidines
    Bayer Pharma Aktiengesellschaft
    03/21/17
  5407. 8
    Substituted imidazopyrazines as Akt kinase inhibitors
    Bayer Pharma Aktiengesellschaft
    03/21/17
  5408. 23
    Inhibitors of leukotriene production
    Boehringer Ingelheim International
    03/13/17
  5409. 1518
    NAMPT and rock inhibitors
    Abbvie
    03/13/17
  5410. 6
    Amino-pyrroline derivatives, and use thereof in the prevention and/or treatment of metabolic syndrome
    Universite De Strasbourg
    03/06/17
  5411. 213
    Diacylglycerol acyltransferase 2 inhibitors
    Pfizer
    03/06/17
  5412. 242
    Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
    Amgen
    03/06/17
  5413. 405
    Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
    Amgen
    03/06/17
  5414. 112
    Pyridinones
    Boehringer Ingelheim International
    03/06/17
  5415. 2
    Synthesis, methods of using, and compositions of cycloalkylmethylamines
    Reviva Pharmaceuticals
    03/06/17
  5416. 4
    Use of dibenzofuranone derivatives to inhibit kinases
    TBA
    03/06/17
  5417. 17
    Piperidylpyrimidine derivatives as modulators of protein kinase inhibitors and of vascular endothelial growth factor receptor 2
    Allergan
    02/28/17
  5418. 2
    Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
    University Of Utah Research Foundation
    02/28/17
  5419. 26
    Therapeutic compounds
    Regents Of The University Of Minnesota
    02/28/17
  5420. 29
    1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof
    Jiangsu Simovay Pharmaceutical
    02/27/17
  5421. 66
    Acyl piperidine inhibitors of soluble epoxide hydrolase
    The Regents Of The University Of California
    02/27/17
  5422. 18
    Heterocyclyl aminoimidazopyridazines
    Bayer Intellectual Property
    02/27/17
  5423. 725
    Inhibitors of poly(ADP-ribose)polymerase
    Abbvie
    02/27/17
  5424. 3
    Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
    Ambit Biosciences
    02/27/17
  5425. 42
    6-Alkynyl Pyridine
    Boehringer Ingelheim International
    02/21/17
  5426. 8
    Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
    Merck Sharp & Dohme
    02/21/17
  5427. 297
    Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
    Novartis
    02/21/17
  5428. 4
    Cyclobutyl benzimidazoles as PDE 10 inhibitors
    Merck Sharp & Dohme
    02/21/17
  5429. 106
    Imidazopyridine compounds
    Astellas Pharma
    02/21/17
  5430. 32
    Oxazine derivatives and their use in the treatment of disease
    Novartis
    02/21/17
  5431. 1
    Pyrazole compounds
    Eli Lilly
    02/21/17
  5432. 6
    Pyrazolyl-pyrimidine derivatives as kinase inhibitors
    Nerviano Medical Sciences
    02/21/17
  5433. 2
    Pyrido-pyrimidine derivatives
    Merck Patent
    02/21/17
  5434. 25
    Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions
    University Of Utah Research Foundation
    02/21/17
  5435. 29
    Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors
    Bayer Intellectual Property
    02/21/17
  5436. 16
    Three-ring PI3K and/or mTOR inhibitor
    Zuanzhu Pharma
    02/21/17
  5437. 25
    Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
    Merck Sharp & Dohme
    02/14/17
  5438. 31
    Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
    Acetylon Pharmaceuticals
    02/14/17
  5439. 290
    Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    Merck Sharp & Dohme
    02/14/17
  5440. 4
    Aldosterone synthase inhibitors
    Merck Sharp & Dohme
    02/13/17
  5441. 14
    Antagonists of prostaglandin EP3 receptor
    Pfizer
    02/13/17
  5442. 16
    Methods for increasing the stabilization of hypoxia inducible factor-α
    Aerpio Therapeutics
    02/13/17
  5443. 128
    Nitrogen-containing saturated heterocyclic compound
    Mitsubishi Tanabe Pharma
    02/13/17
  5444. 4
    Optically active diazabicyclooctane derivatives and process for preparing the same
    Meiji Seika Pharma
    02/13/17
  5445. 149
    Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    02/13/17
  5446. 1
    SARMs and method of use thereof
    University Of Tennessee Research Foundation
    02/13/17
  5447. 16
    Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors
    Hoffmann-La Roche
    02/13/17
  5448. 8
    Amino-substituted imidazopyridazines
    Bayer Pharma Aktiengesellschaft
    02/06/17
  5449. 33
    Aminopyrimidines as Syk inhibitors
    Merck Sharp & Dohme
    02/06/17
  5450. 137
    B-RAF kinase inhibitors
    Boehringer Ingelheim International
    02/06/17
  5451. 13
    Monocyclic heteroaryl cycloalkyldiamine derivatives
    Novartis
    02/06/17
  5452. 182
    N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
    Novartis
    02/06/17
  5453. 74
    Pharmaceutical composition for treating diabetes
    Ajinomoto
    02/06/17
  5454. 270
    Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    02/06/17
  5455. 211
    Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Boehringer Ingelheim International
    02/06/17
  5456. 11
    Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
    Gilead Sciences
    02/06/17
  5457. 422
    Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
    Senomyx
    02/02/17
  5458. 49
    Cyclic amides
    Hoffmann-La Roche
    01/30/17
  5459. 58
    Fused tricyclic compounds as Raf kinase inhibitors
    Beigene
    01/30/17
  5460. 7
    Inhibitors of β-secretase
    Vitae Pharmaceuticals
    01/30/17
  5461. 66
    Pyridazinone compounds and their use as DAAO inhibitors
    Takeda Pharmaceutical
    01/30/17
  5462. 382
    Pyridine derivatives as agonists of the CB2 receptor
    Hoffmann-La Roche
    01/30/17
  5463. 5
    Radiolabeled compounds and uses thereof
    Columbia University
    01/30/17
  5464. 26
    Substituted isoquinolines as CRTH2 receptor modulators
    Merck Sharp & Dohme
    01/30/17
  5465. 79
    Sulfur-containing heterocyclic derivative having Beta secretase inhibitory activity
    Shionogi
    01/30/17
  5466. 34
    TRPV1 antagonists including dihydroxy substituent and uses thereof
    Purdue Pharma
    01/30/17
  5467. 83
    Aurora kinase inhibitors and methods of making and using thereof
    H. Lee Moffitt Cancer Center And Research Institute
    01/27/17
  5468. 9
    5-amino[1,4]thiazines as BACE 1 inhibitors
    Hoffmann-La Roche
    01/25/17
  5469. 39
    Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
    Bristol-Myers Squibb
    01/24/17
  5470. 187
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    01/23/17
  5471. 67
    Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
    Kainos Medicine
    01/23/17
  5472. 3
    Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof
    Boston College
    01/23/17
  5473. 5
    Phthalazinone ketone derivative, preparation method thereof, and pharmaceutical use thereof
    Jiangsu Hansoh Pharmaceutical
    01/23/17
  5474. 58
    Pyridine-and pyrazine derivatives
    Merck Patent
    01/23/17
  5475. 19
    Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
    Dana-Farber Cancer Institute
    01/23/17
  5476. 2
    Pyrrolo[2,3-D]pyrimidine compounds
    Zoetis Services
    01/23/17
  5477. 143
    Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
    Novartis
    01/23/17
  5478. 61
    Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
    Boehringer Ingelheim International
    01/23/17
  5479. 14
    Substituted pyridazines for the treatment of pain
    Inhibitaxin
    01/23/17
  5480. 135
    Substituted pyridone derivatives as PDE10 inhibitors
    Merck Sharp & Dohme
    01/23/17
  5481. 29
    Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
    President And Fellows Of Harvard College
    01/18/17
  5482. 36
    Oligomer-opioid agonist conjugates
    Nektar Therapeutics
    01/18/17
  5483. 11
    Sulfamides as TRPM8 modulators
    Janssen Pharmaceutica
    01/18/17
  5484. 243
    4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
    Actelion Pharmaceuticals
    01/17/17
  5485. 45
    Heteroaromatic methyl cyclic amine derivative
    Taisho Pharmaceutical
    01/17/17
  5486. 163
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Calistoga
    01/17/17
  5487. 8
    Substituted azaindazole compounds
    Bristol-Myers Squibb
    01/17/17
  5488. 42
    Substituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide derivatives as kinase inhibitors
    Allergan
    01/17/17
  5489. 33
    Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
    Principia Biopharma
    01/17/17
  5490. 22
    Triazolopyridinone PDE10 inhibitors
    Merck Sharp & Dohme
    01/17/17
  5491. 171
    Quinoline derivatives useful as CB-1 inverse agonists
    Janssen Pharmaceutica
    01/16/17
  5492. 195
    Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    01/16/17
  5493. 34
    Potent poxvirus inhibitor
    University Of Pennsylvania
    01/14/17
  5494. 12
    4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases
    Galderma Research & Development
    01/09/17
  5495. 8
    Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    01/09/17
  5496. 206
    Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
    Biomarin Pharmaceutical
    01/09/17
  5497. 89
    Compounds for the treatment of neurodegenerative diseases
    Katholieke Universiteit Levun
    01/09/17
  5498. 509
    Dihydropyrrolopyrimidine derivatives
    Pfizer
    01/09/17
  5499. 68
    Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
    Beigene
    01/09/17
  5500. 5
    Inhibitors of Furin and other pro-protein convertases
    Sanford-Burnham Medical Research Institute
    01/09/17
  5501. 2
    Orally available viridiofungin derivative possessing anti-HCV activity
    Chugai Seiyaku Kabushiki Kaisha
    01/09/17
  5502. 9
    Therapeutic pyrazolyl thienopyridines
    Thesan Pharmaceuticals
    01/09/17
  5503. 2
    Trifluoromethyl pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
    Lycera
    01/09/17
  5504. 110
    3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta
    Sanofi
    01/07/17
  5505. 117
    PDE10a inhibitors for the treatment of type II diabetes
    Janssen Pharmaceutica
    12/31/16
  5506. 35
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    12/31/16
  5507. 17
    Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
    Genentech
    12/28/16
  5508. 5
    Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
    Merck Sharp & Dohme
    12/28/16
  5509. 11
    Orvinol and thevinol derivatives useful in the treatment of depression
    The University Of Bath
    12/28/16
  5510. 3
    P38 MAP kinase inhibitors
    Respivert
    12/28/16
  5511. 405
    Pyrazolo[3,4-c]pyridine compounds and methods of use
    Genetech
    12/28/16
  5512. 42
    Serine/threonine kinase inhibitors
    Array Biopharma
    12/28/16
  5513. 5
    Synthetic methods for spiro-oxindole compounds
    Xenon Pharmaceuticals
    12/28/16
  5514. 11
    Thienopyrimidinone derivatives as mGluR1 antagonists
    Korea Institute Of Science And Technology
    12/28/16
  5515. 33
    Alkylamine derivative
    Ajinomoto
    12/20/16
  5516. 5
    Benzothiazole-based pyridinium compounds
    The University Of Montana
    12/20/16
  5517. 8
    Heteroaryl alkyne compound and use thereof
    Nanjing Sanhome Pharmaceutical
    12/20/16
  5518. 432
    Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
    Actelion Pharmaceuticals
    12/20/16
  5519. 176
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Roche Palo Alto
    12/20/16
  5520. 8
    Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors
    Allergan
    12/20/16
  5521. 25
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors
    Shanghai Institute Of Material Medica, Chinese Academy Of Sciences
    12/20/16
  5522. 52
    Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators
    Vanderbilt University
    12/20/16
  5523. 4
    Xanthine derivative
    Chengdu Easton Pharmaceutical
    12/20/16
  5524. 1
    Therapeutic methods and compositions involving allosteric kinase inhibition
    Amitech Therapeutic Solutions
    12/15/16
  5525. 52
    Aniline derivatives, their preparation and their therapeutic application
    Fovea Pharmaceuticals
    12/12/16
  5526. 60
    Bis-amido pyridines
    Boehringer Ingelheim International
    12/12/16
  5527. 32
    Chemical compounds
    Astrazeneca
    12/12/16
  5528. 9
    Indolizinone based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
    Council Of Scientific & Industrial Research
    12/12/16
  5529. 93
    Pyrazole derivatives as p38 MAP inhibitors
    Respivert
    12/12/16
  5530. 7
    Pyridinones/pyrazinones, method of making, and method of use thereof
    Genentech
    12/12/16
  5531. 30
    Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
    Bristol-Myers Squibb
    12/12/16
  5532. 12
    Selective glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    12/12/16
  5533. 47
    Thiazole derivatives
    Merck Patent
    12/12/16
  5534. 30
    Fluorescent antagonists of the A3 adenosine receptor
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    12/08/16
  5535. 40
    Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals
    Sanofi
    12/08/16
  5536. 24
    Trk-inhibiting compound
    Ono Pharmaceutical
    12/06/16
  5537. 7
    2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    12/05/16
  5538. 459
    Aminoheteroaryl benzamides as kinase inhibitors
    Novartis
    12/05/16
  5539. 211
    Chromane compounds
    Comentis
    12/05/16
  5540. 59
    Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
    Merck Sharp & Dohme
    12/05/16
  5541. 84
    Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
    Merck Sharp & Dohme
    12/05/16
  5542. 349
    Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
    Merck Sharp & Dohme
    11/29/16
  5543. 36
    1,4 oxazines as BACE1 and/or BACE2 inhibitors
    Siena Biotech
    11/28/16
  5544. 202
    Biaryl amide compounds as kinase inhibitors
    Novartis
    11/28/16
  5545. 11
    Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
    Reviva Pharmaceuticals
    11/28/16
  5546. 24
    Fused pyrazole derivatives as novel ERK inhibitors
    Merck Sharp & Dohme
    11/28/16
  5547. 26
    Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
    Bristol-Myers Squibb
    11/28/16
  5548. 3
    Isoxazolopyridine orexin receptor antagonists
    Merck Sharp & Dohme
    11/28/16
  5549. 464
    Lactam derivatives useful as orexin receptor antagonists
    Actelion Pharmaceuticals
    11/28/16
  5550. 2
    P38MAP kinase inhibitors
    Respivert
    11/28/16
  5551. 7
    Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
    Council Of Scientific & Industrial Research
    11/28/16
  5552. 24
    Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
    Northwestern University
    11/28/16
  5553. 36
    1-H-pyrrolo[2,3-b]pyridine derivatives
    Merck Patent
    11/21/16
  5554. 11
    Beta-amyloid-directed multitarget compounds for the treatment of alzheimer's disease
    Universitat De Barcelona
    11/21/16
  5555. 446
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    11/21/16
  5556. 22
    Heteroaryl compounds and uses thereof
    Celgene Avilomics Research
    11/21/16
  5557. 278
    IRE-1α inhibitors
    Mannkind
    11/21/16
  5558. 76
    Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie Deutschland
    11/21/16
  5559. 147
    Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
    Advinus Therapeutics
    11/21/16
  5560. 32
    Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    11/21/16
  5561. 44
    Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors
    Janssen Pharmaceutica
    11/21/16
  5562. 81
    VEGFR3 inhibitors
    Cancer Therapeutics Crc Pty
    11/21/16
  5563. 289
    Aryl dihydropyridinones and piperidinone MGAT2 inhibitors
    Bristol-Myers Squibb
    11/15/16
  5564. 99
    Compounds and compositions as inhibitors of MEK
    Novartis
    11/14/16
  5565. 15
    Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities
    Almirall
    11/14/16
  5566. 160
    Derivatives of 4-(piperazinylcarbonyl)thiane-1, 1-dione which inhibit GlyT1
    Boehringer Ingelheim International
    11/14/16
  5567. 15
    Gamma secretase inhibitors
    Merck Sharp & Dohme
    11/14/16
  5568. 100
    Inhibition of WDR5 interaction with its binding partners
    The Regents Of The University Of Michigan
    11/14/16
  5569. 30
    Kinase inhibitors
    Allergan
    11/14/16
  5570. 60
    Method of treatment using substituted imidazo[1,2B]pyridazine compounds
    Array Biopharma
    11/14/16
  5571. 4
    Phosphoinositide 3-kinase inhibitors
    Respivert
    11/14/16
  5572. 11
    Pyridine CGRP receptor antagonists
    Merck Sharp & Dohme
    11/14/16
  5573. 67
    Pyrrolo pyrimidine derivatives
    Novartis
    11/14/16
  5574. 41
    Substituted amide compounds
    Pfizer
    11/14/16
  5575. 57
    Sulfonamide compounds
    Kancera
    11/14/16
  5576. 42
    Triazolopyridine compounds
    Hoffmann-La Roche
    11/14/16
  5577. 26
    4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
    Novartis
    11/08/16
  5578. 15
    Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie
    11/08/16
  5579. 198
    Benzylamine derivatives as inhibitors of plasma kallikrein
    Kalvista Pharmaceuticals
    11/08/16
  5580. 97
    Buprenorphine analogs
    Purdue Pharma
    11/08/16
  5581. 458
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    11/08/16
  5582. 6
    Ethynyl derivatives
    Hoffman-La Roche
    11/08/16
  5583. 94
    Heteroarylcarboxylic acid ester derivative
    Ajinomoto
    11/08/16
  5584. 88
    Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
    H. Lee Moffitt Cancer Center And Research Institute
    11/08/16
  5585. 6
    Spirocyclic molecules as protein kinase inhibitors
    Nanjing Allgen Pharma
    11/08/16
  5586. 27
    Tricyclic indole derivatives useful endothelial lipase inhibitors
    Janssen Pharmaceutica
    11/08/16
  5587. 4
    Inhibitors of protein tyrosine phosphatases
    Indiana University Research And Technology
    11/02/16
  5588. 10
    Arylethynyl derivatives
    Hoffman-La Roche
    10/31/16
  5589. 15
    C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    10/31/16
  5590. 120
    Heterocyclic amide derivatives as P2X7 receptor antagonists
    Actelion Pharmaceuticals
    10/31/16
  5591. 5
    Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
    Incyte Holdings
    10/31/16
  5592. 85
    Inhibitors of c-fms kinase
    Janssen Pharmaceutica
    10/31/16
  5593. 6
    Metalloenzyme inhibitor compounds
    Viamet Pharmaceuticals
    10/31/16
  5594. 21
    N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]sulfonamides as pharmaceuticals
    Sanofi
    10/31/16
  5595. 137
    Selective NR2B antagonists
    Bristol-Myers Squibb
    10/31/16
  5596. 459
    Substituted pyrrolo[2,3-h][1,6]naphthyridines and compositions thereof as JAK inhibitors
    Nissan Chemical Industries
    10/31/16
  5597. 2
    3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors
    Incyte
    10/24/16
  5598. 12
    3-aryl-2-((arylamino)methyl)quinazolin-4-(3H)-ones
    Scifluor Life Sciences
    10/24/16
  5599. 16
    Benzamide derivatives
    Dong-A Pharm.
    10/24/16
  5600. 203
    Benzyl sulfonamide derivatives as RORc modulators
    Genentech
    10/24/16
  5601. 237
    Heterocyclic derivative and pharmaceutical drug
    Nippon Shinyaku
    10/24/16
  5602. 95
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences
    10/24/16
  5603. 44
    Purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative, pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition with inhibitory activity against Raf kinase, containing same as active ingredient
    Medpacto
    10/24/16
  5604. 50
    Quinoline derivatives as PDE10A enzyme inhibitors
    H. Lundbeck
    10/24/16
  5605. 13
    Substituted phthalazinones as rock inhibitors
    Bristol-Myers Squibb
    10/24/16
  5606. 75
    Thiazole compounds, methods for preparation and use thereof
    Shanghai Puyi Chemical
    10/24/16
  5607. 21
    Tri-heterocyclic derivatives, preparation process and uses thereof
    Shanghai De Novo Pharmatech
    10/24/16
  5608. 23
    Tricyclic heterocyclic compounds
    Bristol-Myers Squibb
    10/24/16
  5609. 99
    Tyrosine kinase inhibitors
    Principia Biopharma
    10/19/16
  5610. 4
    4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use
    TBA
    10/18/16
  5611. 102
    Carbamate/urea derivatives containing piperidin and piperazin rings as H3 receptor inhibitors
    Novartis
    10/18/16
  5612. 109
    Pyrazole compounds as CRTH2 antagonists
    Boehringer Ingelheim International
    10/18/16
  5613. 16
    2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
    Northwestern University
    10/17/16
  5614. 4
    6-thio-substituted imidazo[1,2-a]pyrazines as Mps-1 inhibitors
    Bayer Intellectual Property
    10/17/16
  5615. 59
    Bicyclic carboxamide inhibitors of kinases
    Abbvie
    10/17/16
  5616. 19
    Bicyclic pyrazole LRRK2 small molecule inhibitors
    Genentech
    10/17/16
  5617. 34
    Dihydroxy aromatic heterocyclic compound
    Takeda Pharmaceutical
    10/17/16
  5618. 43
    Ethynyl compounds
    Hoffmann-La Roche
    10/17/16
  5619. 33
    Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof
    Universite Paris Descartes
    10/17/16
  5620. 13
    Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation
    Otsuka Pharmaceutical
    10/17/16
  5621. 36
    Pyrazole aminopyrimidine derivatives as LRRK2 modulators
    Genentech
    10/17/16
  5622. 32
    Substituted pyrimidine compounds and their use as SYK inhibitors
    Genosco
    10/17/16
  5623. 3
    Urea derivatives and uses thereof
    Kala Pharmaceuticals
    10/17/16
  5624. 3
    (5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment
    Bayer Intellectual Property
    10/11/16
  5625. 67
    Aryl substituted indoles and their use as blockers of sodium channels
    Purdue Pharma
    10/11/16
  5626. 25
    Bicarbocyclic and tricarbocyclic ethynyl derivatives and uses of same
    H. Lundbeck
    10/11/16
  5627. 1
    Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
    Counsel Of Scientific & Industrial Research
    10/11/16
  5628. 179
    Heterocyclic derivative and pharmaceutical composition comprising the same
    Shionogi
    10/11/16
  5629. 196
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    10/11/16
  5630. 201
    Organic compounds and their uses
    Novartis
    10/11/16
  5631. 54
    Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
    Arrien Pharmaceuticals
    10/11/16
  5632. 35
    Therapeutic compounds for blocking DNA synthesis of POX viruses
    University Of Pennsylvania
    10/11/16
  5633. 88
    Heterocyclic compounds for the treatment of stress-related conditions
    Otsuka Pharmaceutical
    10/10/16
  5634. 15
    Phenoxazine derivatives and methods of use thereof
    Washington University
    10/04/16
  5635. 53
    Agent for treatment of eye diseases
    Daito Chemix
    10/03/16
  5636. 5
    Aggrecanase inhibitors
    Eli Lilly
    10/03/16
  5637. 115
    Disubstituted benzothienyl-pyrrolotriazines and uses thereof
    Bayer Intellectual Property
    10/03/16
  5638. 541
    Inhibitors of beta-secretase
    Vitae Pharmaceuticals
    10/03/16
  5639. 76
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    10/03/16
  5640. 65
    Piperazine-substituted benzothiophenes for treatment of mental disorders
    Otsuka Pharmaceutical
    10/03/16
  5641. 50
    Triazole compounds that modulate Hsp90 activity
    Synta Pharmaceuticals
    10/03/16
  5642. 72
    Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction
    Emory University
    10/03/16
  5643. 27
    6-oxopurine phosphoribosyltransferase inhibitors
    The University Of Queensland
    09/27/16
  5644. 168
    Compounds and compositions as C-kit kinase inhibitors
    Novartis
    09/27/16
  5645. 5
    Compounds and methods for purification of serine proteases
    Portola Pharmaceuticals
    09/27/16
  5646. 17
    Haematopoietic-prostaglandin D2 synthase inhibitors
    The University Of Queensland
    09/27/16
  5647. 1
    N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukemia
    Pfizer
    09/27/16
  5648. 6
    Protease inhibitors
    Medivir
    09/27/16
  5649. 1
    Purinone derivative hydrochloride
    Ono Pharmaceutical
    09/27/16
  5650. 167
    Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
    Allergan
    09/27/16
  5651. 73
    Substituted imidazopyrazines
    Bayer Intellectual Property
    09/27/16
  5652. 117
    Triazolyl PDE10 inhibitors
    Merck Sharp & Dohme
    09/27/16
  5653. 139
    Biaryl-propionic acid derivatives and their use as pharmaceuticals
    Sanofi
    09/20/16
  5654. 55
    Guanidinobenzoic acid compound
    Astellas Pharma
    09/20/16
  5655. 90
    N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or pharmaceutically acceptable salt thereof, and composition containing same as active ingredient for preventing or treating cancer
    Korea Research Institute Of Chemical Technology
    09/20/16
  5656. 7
    Selective glycosidase inhibitors and uses thereof
    Alectos Therapeutics
    09/20/16
  5657. 18
    3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
    Institute Of Cancer Research
    09/19/16
  5658. 46
    Azaindole derivatives as tyrosine kinase inhibitors
    Principia Biopharma
    09/19/16
  5659. 66
    Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    09/19/16
  5660. 38
    Oxazole derivatives useful as modulators of FAAH
    Merck Sharp & Dohme
    09/19/16
  5661. 166
    PDE 10a inhibitors for the treatment of type II diabetes
    Janssen Pharmaceutica
    09/19/16
  5662. 32
    Selective inhibitors of prolylcarboxypeptidase
    University Of Mississippi
    09/19/16
  5663. 72
    Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
    Pfizer
    09/19/16
  5664. 9
    Anti-mucus drugs and uses therefor
    Washington University
    09/12/16
  5665. 15
    Azabenzimidazole derivatives
    Boehringer Ingelheim International
    09/12/16
  5666. 101
    Bicyclic pyridazine compounds as Pim inhibitors
    Amgen
    09/12/16
  5667. 30
    Bisaryl-bonded aryltriazolones and use thereof
    Bayer Intellectual Property
    09/12/16
  5668. 17
    Morpholinylbenzotriazines for use in cancer therapy
    Merck Patent
    09/12/16
  5669. 22
    Peripherally restricted diphenyl purine derivatives
    Research Triangle Institute
    09/12/16
  5670. 5
    Quinazoline-7-ether compounds and methods of use
    Newgen Therapeutics
    09/12/16
  5671. 2
    Raf inhibitor compounds
    Deciphera Pharmaceuticals
    09/12/16
  5672. 24
    Substituted oxadiazole compounds
    Bristol-Myers Squibb
    09/12/16
  5673. 56
    Substituted pyridine compound
    Daiichi Sankyo
    09/12/16
  5674. 118
    Substituted quinazolines as serine/threonine kinase inhibitors
    Array Biopharma
    09/12/16
  5675. 84
    p53-Mdm2 antagonists
    University Of Pittsburgh
    09/12/16
  5676. 9
    Curcumin analogues as zinc chelators and their uses
    The Research Foundation Of State University Of New York
    09/06/16
  5677. 16
    Hepsin inhibitors
    Fred Hutchinson Cancer Research Center
    09/06/16
  5678. 25
    Inhibitors of bruton's tyrosine kinase
    Pharmacyclics
    09/06/16
  5679. 6
    Peripherally restricted FAAH inhibitors
    University Of California
    09/06/16
  5680. 72
    Phenyl-tetrahydroisoquinoline derivatives
    Hoffmann-La Roche
    09/06/16
  5681. 9
    Poly (ADP-ribose) polymerase inhibitor
    Chengdu Di'Ao Pharmaceutical Group
    09/06/16
  5682. 2
    Quinolyl-containing hydroxamic acid compound and preparation method thereof, and pharmaceutical composition containing this compound and use thereof
    Beijing Konruns Pharmaceutical
    09/06/16
  5683. 49
    Substituted dicyanopyridines and use thereof
    Bayer Intellectual Property
    09/06/16
  5684. 11
    Therapeutic curcumin derivatives
    Stc.Unm
    09/06/16
  5685. 103
    Treatment of respiratory disorders using TRPA1 antagonists
    Glenmark Pharmaceuticals
    09/06/16
  5686. 98
    2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
    Novartis
    08/29/16
  5687. 174
    2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
    Merck Sharp & Dohme
    08/29/16
  5688. 22
    Adenosine receptor agonists, partial agonists, and antagonists
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    08/29/16
  5689. 265
    Aldosterone synthase inhibitors
    Boehringer Ingelheim International
    08/29/16
  5690. 15
    Cyclic amine derivatives as EP4 receptor antagonists
    Rottapharm Biotech
    08/29/16
  5691. 28
    Inhibitors of glutaminyl cyclase
    Probiodrug
    08/29/16
  5692. 4
    Mercaptoamidine derivatives and methods of use
    Abbvie
    08/29/16
  5693. 64
    Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
    Nerviano Medical Sciences
    08/29/16
  5694. 140
    Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
    Takeda Pharmaceutical
    08/29/16
  5695. 10
    TrkA kinase inhibitors, compositions and methods thereof
    Merck Sharp & Dohme
    08/29/16
  5696. 41
    2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease
    Albireo
    08/15/16
  5697. 35
    5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain
    Takeda Pharmaceutical
    08/15/16
  5698. 20
    Compounds of modulating TRPV3 function
    Hydra Biosciences
    08/15/16
  5699. 31
    Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
    Cayman Chemical
    08/15/16
  5700. 23
    Fragment ligated inhibitors selective for the polo box domain of PLK1
    University Of South Carolina
    08/15/16
  5701. 22
    Heteroaryl compounds as sodium channel blockers
    Purdue Pharma
    08/15/16
  5702. 17
    Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
    Amicus Therapeutics
    08/15/16
  5703. 54
    Morpholine compounds and uses thereof
    Hoffmann-La Roche
    08/15/16
  5704. 8
    Phospholipid drug analogs
    Telormedix
    08/15/16
  5705. 35
    S1P receptors modulators
    Akaal Pharma
    08/15/16
  5706. 19
    Substituted N-phenethyltriazoloneacetamides and use thereof
    Bayer Intellectual Property
    08/15/16
  5707. 12
    Therapeutic agent for urinary excretion disorder
    Ono Pharmaceutical
    08/15/16
  5708. 46
    mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    08/15/16
  5709. 29
    4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof
    Bayer Intellectual Property
    08/08/16
  5710. 346
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    08/08/16
  5711. 7
    Buprenorphine analogs
    Purdue Pharma
    08/08/16
  5712. 68
    Indoline scaffold SHP-2 inhibitors and cancer treatment method
    University Of South Florida
    08/08/16
  5713. 63
    Inhibitors of human EZH2, and methods of use thereof
    Epizyme
    08/08/16
  5714. 43
    Macrocyclic factor VIIa inhibitors
    Bristol-Myers Squibb
    08/08/16
  5715. 11
    Methods and compositions for studying, imaging, and treating pain
    The Board Of Trustees Of The Leland Stanford Junior University
    08/08/16
  5716. 27
    N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals
    Sanofi
    08/08/16
  5717. 1
    Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
    Arena Pharmaceuticals
    08/08/16
  5718. 233
    Substituted azoanthracene derivatives and intermediates for preparation thereof
    Vtv Therapeutics
    08/08/16
  5719. 25
    Inhibitors of phosphodiesterase 11 (PDE11)
    Boston College
    08/02/16
  5720. 8
    Phospholipid drug analogs
    Telormedix
    08/02/16
  5721. 6
    Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators
    Bristol-Myers Squibb
    08/02/16
  5722. 24
    TSH receptor antagonizing tetrahydroquinoline compounds
    Merck Sharp & Dohme
    08/02/16
  5723. 120
    1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
    Actelion Pharmaceuticals
    08/01/16
  5724. 394
    Amidopyrazole inhibitors of interleukin receptor-associated kinases
    Merck Sharp & Dohme
    08/01/16
  5725. 1
    Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a ]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
    Bristol-Myers Squibb
    08/01/16
  5726. 43
    Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Curis
    08/01/16
  5727. 205
    Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
    Sanofi
    08/01/16
  5728. 134
    Compounds and methods for treating tuberculosis infection
    Academia Sinica
    07/26/16
  5729. 155
    Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
    Janssen Pharmaceutica
    07/26/16
  5730. 45
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences
    07/25/16
  5731. 118
    Compounds and compositions for the inhibition of NAMPT
    Forma Tm
    07/25/16
  5732. 585
    Heteroaryl substituted nicotinamide compounds
    Bristol-Myers Squibb
    07/25/16
  5733. 91
    Imidazopyridazine compounds
    Hoffmann-La Roche
    07/25/16
  5734. 83
    Ketone linked benzothiazole inhibitors of endothelial lipase
    Bristol-Myers Squibb
    07/25/16
  5735. 35
    Morpholino compounds, uses and methods
    University Of Dundee
    07/25/16
  5736. 12
    Sepiapterin reductase inhibitors for the treatment of pain
    Solace Pharmaceuticals
    07/25/16
  5737. 17
    Anti-viral compounds
    Abbvie
    07/18/16
  5738. 6
    Beta carboline derivatives useful in the treatment of proliferative disorders
    Facultes Universitaires Notre Dame De La Paix
    07/18/16
  5739. 74
    Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
    Vitae Pharmaceuticals
    07/18/16
  5740. 37
    Oxazine derivatives and their use in the treatment of disease
    Novartis
    07/18/16
  5741. 24
    Prodrugs of pyridone amides useful as modulators of sodium channels
    Vertex Pharmaceuticals
    07/18/16
  5742. 90
    Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    07/18/16
  5743. 197
    Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    07/18/16
  5744. 210
    Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
    Pfizer
    07/18/16
  5745. 26
    Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
    Merck Canada
    07/18/16
  5746. 1
    Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors
    Novartis
    07/18/16
  5747. 31
    Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
    Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.
    07/18/16
  5748. 47
    1,5-Diary1-2-alkylpyrrole-3-substituted nitro esters, selective COX-2 inhibitors and nitric oxide donors
    Rottapharm Biotech
    07/11/16
  5749. 1
    4-isopropyl-6-methoxyphenyl glucitol compound
    Taisho Pharmaceutical
    07/11/16
  5750. 38
    4-piperidinyl compounds for use as tankyrase inhibitors
    Novartis
    07/11/16
  5751. 87
    5-substituted indazoles as kinase inhibitors
    Abbvie
    07/11/16
  5752. 2
    Chrysophaentin analogs that inhibit FtsZ protein
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    07/11/16
  5753. 53
    Cinnamoyl inhibitors of transglutaminase
    University Of Ottawa
    07/11/16
  5754. 44
    Functionally selective ligands of dopamine D2 receptors
    University Of North Carolina At Chapel Hill
    07/11/16
  5755. 2
    Indolinone protein kinase inhibitors
    Beta Pharma
    07/11/16
  5756. 103
    Pyrimidines as sodium channel blockers
    Purdue Pharma
    07/11/16
  5757. 2
    Pyrrolo[2,3-d]pyrimidine compounds
    Zoetis Services
    07/11/16
  5758. 30
    Quinazoline compounds as sodium channel blockers
    Purdue Pharma
    07/11/16
  5759. 5
    Reactivators of organophosphorous inhibited acetylcholinesterase
    Southwest Research Institute
    07/11/16
  5760. 204
    4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors
    Pfizer
    06/30/16
  5761. 26
    Amine oxidase inhibitors
    Case Western Reserve University
    06/30/16
  5762. 44
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    06/30/16
  5763. 10
    Chemical compounds
    Astrazeneca
    06/30/16
  5764. 148
    Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists
    Takeda Pharmaceutical
    06/30/16
  5765. 5
    Factor IXa inhibitors
    Merck Sharp & Dohme
    06/30/16
  5766. 52
    Heterocyclic compounds
    Shionogi
    06/30/16
  5767. 8
    Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases
    Hanmi Pharm.
    06/30/16
  5768. 4
    Treating diabetes with dipeptidyl peptidase-IV inhibitors
    Merck Sharp & Dohme
    06/30/16
  5769. 5
    Tricyclic triazole compounds that modulate HSP90 activity
    Synta Pharmaceuticals
    06/30/16
  5770. 198
    2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-YL)picolinamide derivatives as orexin receptor antagonists
    Actelion Pharmaceuticals
    06/20/16
  5771. 171
    5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors
    Boehringer Ingelheim International
    06/20/16
  5772. 208
    Biaryl-propionic acid derivatives and their use as pharmaceuticals
    Sanofi
    06/20/16
  5773. 44
    Bicyclic heterocycle compounds and their uses in therapy
    Astex Therapeutics
    06/20/16
  5774. 8
    Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
    Boehringer Ingelheim International
    06/20/16
  5775. 237
    Heterocyclic compounds containing an indole core
    Boehringer Ingelheim International
    06/20/16
  5776. 505
    N-myristoyl transferase inhibitors
    Univeristy Of Dundee
    06/20/16
  5777. 11
    Nicotinic receptor compounds
    Research Triangle Institute
    06/20/16
  5778. 6
    Selective PI3K delta inhibitors
    Rhizen Pharmaceuticals
    06/20/16
  5779. 22
    Treatment of inflammatory bowel disease
    Allergan
    06/20/16
  5780. 154
    6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
    Merck Serono
    06/14/16
  5781. 68
    1,2,4-triazine-6-carboxamide derivative
    Taiho Pharmaceutical
    06/13/16
  5782. 5
    5-fluoro-3-phenyl-2-[1-(9h-purin-6-ylamino)propyl]-3h-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta
    Icos
    06/13/16
  5783. 37
    Aminopyrimidine derivatives as LRRK2 modulators
    Genentech
    06/13/16
  5784. 242
    Bipyridylaminopyridines as Syk inhibitors
    Merck Sharp & Dohme
    06/13/16
  5785. 239
    Bis-(sulfonylamino) derivatives for use in therapy
    Astrazeneca
    06/13/16
  5786. 68
    Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin
    The Procter & Gamble
    06/13/16
  5787. 399
    Imidazole amines as modulators of kinase activity
    Merck Patent
    06/13/16
  5788. 10
    Imidazopyridazinyl compounds
    Bristol-Myers Squibb
    06/13/16
  5789. 2
    Metalloenzyme inhibitor compounds
    Innocrin Pharmaceuticals
    06/13/16
  5790. 13
    Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
    Dartmouth College
    06/13/16
  5791. 217
    Pharmaceutical compounds
    Astex Therapeutics
    06/13/16
  5792. 19
    Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    06/13/16
  5793. 26
    Selective HDAC1 and HDAC2 inhibitors
    Acetylon Pharmaceuticals
    06/13/16
  5794. 5
    Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
    Nerviano Medical Sciences
    06/13/16
  5795. 7
    Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators
    Purdue Pharma
    06/13/16
  5796. 91
    Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application
    Sanofi
    06/13/16
  5797. 325
    Triazine derivative and pharmaceutical composition comprising the same
    Shionogi
    06/13/16
  5798. 24
    Amide or urea containing benzothiazole inhibitors of endothelial lipase
    Bristol-Myers Squibb
    06/06/16
  5799. 21
    Azetidine compounds, compositions and methods of use
    Hoffmann-La Roche
    06/06/16
  5800. 68
    Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin
    The Procter & Gamble
    06/06/16
  5801. 119
    Heterocyclic carboxamides as modulators of kinase activity
    Merck Patent
    06/06/16
  5802. 49
    Inhibitors of the Renal Outer Medullary Potassium channel
    Merck Sharp & Dohme
    06/06/16
  5803. 7
    Methods of treatment of histamine H-4 receptor-related pruritus
    Bridge Pharma
    06/06/16
  5804. 8
    Radiolabeled PDE10A ligands
    Abbvie
    06/06/16
  5805. 80
    Substituted quinoxalines as sodium channel modulators
    Vertex Pharmaceuticals
    06/06/16
  5806. 295
    Sulfoximine substituted quinazolines for pharmaceutical compositions
    Boehringer Ingelheim International
    06/06/16
  5807. 16
    Tri-aryl/heteroaromatic cannabinoids and use thereof
    The University Of Tennessee Research Foundation
    06/06/16
  5808. 2
    Use of inhibitors of porphobilinogen deaminase in the treatment of congenital erythropoietic porphyria
    AsociacióN Centro De InvestigacióN Cooperativa En Biociencias—Cic Biogune
    06/06/16
  5809. 11
    Aurora and FLT3 kinases modulators
    Sareum
    05/23/16
  5810. 259
    Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists
    Boehringer Ingelheim International
    05/23/16
  5811. 39
    Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group
    Bayer Intellectual Property
    05/23/16
  5812. 82
    Dual modulators of 5HT2A and D3 receptors
    Hoffmann-La Roche
    05/23/16
  5813. 9
    Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
    Deciphera Pharmaceuticals
    05/23/16
  5814. 10
    Inhibitors of Bruton's tyrosine kinase
    Pharmacyclics
    05/23/16
  5815. 7
    Oxidated derivatives of triazolylpurines useful as ligands of the adenosine A2A receptor and their use as medicaments
    Sigma-Tau Industrie Farmaceutiche Riunite
    05/23/16
  5816. 19
    Pyrazolone derivatives as PDE4 inhibitors
    Takeda
    05/23/16
  5817. 2
    Pyrimidine derivatives as protein kinase inhibitors
    Cyclacel
    05/23/16
  5818. 37
    Selective androgen receptor modulators
    Radius Health
    05/23/16
  5819. 85
    Serine/threonine kinase inhibitors
    Array Biopharma
    05/23/16
  5820. 6
    Antiviral compounds
    Katholieke Universiteit Leuven
    05/16/16
  5821. 91
    Carbamate compounds and of making and using same
    The Scripps Research Institute
    05/16/16
  5822. 130
    HIV protease inhibitors
    Merck Canada
    05/16/16
  5823. 1
    Inhibitors of bruton's tyrosine kinase
    Pharmacyclics
    05/16/16
  5824. 4
    Methods for treating GI tract disorders
    Neurogastrx
    05/16/16
  5825. 38
    Morphan and morphinan analogues, and methods of use
    Alkermes Pharma Ireland
    05/16/16
  5826. 117
    Pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
    Sanofi
    05/16/16
  5827. 19
    Pyrimidine diol amides as sodium channel blockers
    Purdue Pharma
    05/16/16
  5828. 15
    Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators
    Bristol-Meyers Squibb
    05/16/16
  5829. 7
    Substituted quinoline compounds and methods of use
    Sunshine Lake Pharma
    05/16/16
  5830. 4
    Transcription factor modulators
    C&C Biopharma
    05/16/16
  5831. 5
    1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
    The Regents Of The University Of Michigan
    05/09/16
  5832. 12
    Compounds for inhibiting the interaction of BCL2 with binding partners
    Novartis
    05/09/16
  5833. 45
    Compounds for inhibiting the interaction of BCL2 with binding partners
    Novartis
    05/09/16
  5834. 36
    Epoxyeicosatrienoic acid analogs and methods of making and using the same
    The Medical College Of Wisconsin
    05/09/16
  5835. 25
    Inhibitors of glutaminyl cyclase
    Probiodrug
    05/09/16
  5836. 9
    Isoform selective phospholipase D inhibitors
    Vanderbilt University
    05/09/16
  5837. 67
    Morpholinylquinazolines
    Merck Patent
    05/09/16
  5838. 57
    Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
    Cayman Chemical
    05/09/16
  5839. 10
    Selective glycosidase inhibitors and uses thereof
    Merck Sharp & Dohme
    05/09/16
  5840. 63
    Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them
    Sanofi
    05/09/16
  5841. 41
    Substituted benzopiperazines as CETP inhibitors
    Merck Sharp & Dohme
    05/09/16
  5842. 17
    Antitumor agent
    Mitsubishi Tanabe Pharma
    05/02/16
  5843. 431
    Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
    Abbvie
    05/02/16
  5844. 14
    Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
    Incyte Holdings
    05/02/16
  5845. 260
    Pyrimidooxazocine derivatives as mTOR-inhibitors
    Sanofi
    05/02/16
  5846. 4
    Saccharide conjugates
    Curators Of The University Of Missouri
    05/02/16
  5847. 42
    Substituted clavulanic acid
    Nabriva Therapeutics
    05/02/16
  5848. 6
    Substituted pyridazine carboxamide compounds
    Xcovery Holding
    05/02/16
  5849. 262
    Tetracyclic compound
    Chugai Seiyaku Kabushiki Kaisha
    05/02/16
  5850. 39
    Treatment of hyperproliferative disorders with diarylhydantoin compounds
    The Regents Of The University Of California
    05/02/16
  5851. 50
    Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor
    Bristol-Myers Squibb
    04/25/16
  5852. 171
    Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
    Boehringer Ingelheim International
    04/25/16
  5853. 17
    Azetidine derivative and antidepressant composition including the same
    Korea Institute Of Science And Technology
    04/25/16
  5854. 3
    Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
    Galderma Research & Development
    04/25/16
  5855. 37
    Indole or indazole derivative or salt thereof
    Taiho Pharmaceutical
    04/25/16
  5856. 115
    Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
    Les Laboratoires Servier
    04/25/16
  5857. 27
    Process for preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds
    Gruenenthal
    04/25/16
  5858. 11
    Pyridyl aminopyridines as Syk inhibitors
    Merck Sharp & Dohme
    04/25/16
  5859. 7
    Selective glycosidase inhibitors and uses thereof
    Simon Fraser University
    04/25/16
  5860. 7
    Thienopyrimidine compounds
    Vernalis (R&D
    04/25/16
  5861. 14
    Triazine carboxamides as sodium channel blockers
    Purdue Pharma
    04/25/16
  5862. 70
    1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof
    Sanofi
    04/18/16
  5863. 20
    Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase
    Amicus Therapeutics
    04/18/16
  5864. 8
    Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK)
    University Of Maryland, Baltimore
    04/18/16
  5865. 38
    Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
    University Of Michigan
    04/18/16
  5866. 40
    Pyridine compounds as sodium channel blockers
    Purdue Pharma
    04/18/16
  5867. 612
    Quinoline derivatives and MELK inhibitors containing the same
    Oncotherapy Science
    04/18/16
  5868. 13
    Selective FAK inhibitors
    Cancer Therapeutics Crc
    04/18/16
  5869. 40
    Substituted phenylureas and phenylamides as vanilloid receptor ligands
    Gruenenthal
    04/18/16
  5870. 4
    Triazole compounds that modualte HSP90 activity
    Synta Pharmaceuticals
    04/18/16
  5871. 1
    Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
    Confluence Life Sciences
    04/12/16
  5872. 20
    Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
    Sanofi
    04/12/16
  5873. 10
    1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives
    Merck Sharp & Dohme
    04/11/16
  5874. 61
    Compounds and methods for kinase modulation, and indications therefor
    Plexxikon
    04/11/16
  5875. 70
    Compounds from Antrodia cinnamomea and use thereof
    Simpson Biotech
    04/11/16
  5876. 1
    Crystalline forms of a prolyl hydroxylase inhibitor
    Fibrogen
    04/11/16
  5877. 7
    Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension
    TBA
    04/11/16
  5878. 7
    Dual action inhibitors against histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase
    National Taiwan University
    04/11/16
  5879. 5
    Fused heterocyclic derivative and pharmaceutical use thereof
    Kissei Pharmaceutical
    04/11/16
  5880. 21
    N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors
    Galderma Research & Development
    04/11/16
  5881. 98
    Substituted piperidine compounds and their use as orexin receptor modulators
    Janssen Pharmaceutica
    04/11/16
  5882. 84
    Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors
    Janssen Pharmaceutica
    04/05/16
  5883. 45
    5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocines as P2X7 modulators
    Janssen Pharmaceutica
    04/04/16
  5884. 180
    Benzamides
    H. Lundbeck
    04/04/16
  5885. 93
    Bicyclic thiazole compounds
    Carna Biosciences
    04/04/16
  5886. 59
    Fatty acid amide hydrolase inhibitors
    University Of Connecticut
    04/04/16
  5887. 1
    Hydroxamic acid derivatives
    Purdue Pharmaceutical Products
    04/04/16
  5888. 15
    N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
    Bristol-Myers Squibb
    04/04/16
  5889. 10
    Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof
    The University Of Toledo
    04/04/16
  5890. 13
    Naphthalene-based inhibitors of anti-apoptotic proteins
    Burnham Institute For Medical Research
    04/04/16
  5891. 440
    Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors
    Kudos Pharmaceuticals
    04/04/16
  5892. 12
    Use of rosuvastatin lactols as medicaments
    Redx Pharma
    04/04/16
  5893. 125
    4-carboxybenzylamino derivatives as histone deacetylase inhibitors
    Merck Sharp & Dohme
    03/28/16
  5894. 51
    7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators
    Actelion Pharmaceuticals
    03/28/16
  5895. 175
    Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
    Boehringer Ingelheim International
    03/28/16
  5896. 53
    Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
    Board Of Regents, The University Of Texas System
    03/28/16
  5897. 26
    Arylamino purine derivatives, preparation method and pharmaceutical use thereof
    Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
    03/28/16
  5898. 5
    Benzofuran derivatives for the treatment of hepatitis C
    Bristol-Myers Squibb
    03/28/16
  5899. 111
    Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors
    H. Lundbeck
    03/28/16
  5900. 22
    Inhibition of memapsin 1 cleavage in the treatment of diabetes
    Oklahoma Medical Research Foundation
    03/28/16
  5901. 5
    Kinase inhibitors and methods of use thereof
    The Broad Institute
    03/28/16
  5902. 12
    Methods of using cycloalkylmethylamine derivatives
    Reviva Pharmaceuticals
    03/28/16
  5903. 111
    P2X7 modulators
    Janssen Pharmaceutica
    03/28/16
  5904. 24
    Quarternized buprenorphine analogs
    Purdue Pharma
    03/28/16
  5905. 17
    Selective HDAC3 inhibitors
    Acetylon Pharmaceuticals
    03/28/16
  5906. 174
    1,2,6-substituted benzimidazoles as flap modulators
    Janssen Pharmaceutica
    03/21/16
  5907. 130
    5-alkynyl-pyridines
    Boehringer Ingelheim International
    03/21/16
  5908. 184
    Aryl- or heteroaryl-substituted benzene compounds
    Epizyme
    03/21/16
  5909. 89
    Benzoxazepin compounds selective for PI3K P110 delta and methods of use
    Genentech
    03/21/16
  5910. 4
    Compound and methods for its production
    Neurovive Pharmaceutical
    03/21/16
  5911. 36
    Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies
    Galderma Research & Development
    03/21/16
  5912. 9
    Specific nNOS inhibitors for the therapy and prevention of human melanoma
    Northwestern University
    03/21/16
  5913. 73
    Substituted benzimidazole-type piperidine compounds and uses thereof
    Purdue Pharma
    03/21/16
  5914. 121
    Substituted pyrido[3,2-E][1,2,4]-triazolo[4,3-A]pyrazines for the treatment of central nervous system disorders
    Boehringer Ingelheim International
    03/21/16
  5915. 9
    Therapeutic pyrazolyl thienopyridines
    Thesan Pharmaceuticals
    03/21/16
  5916. 10
    4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases
    Bayer Intellectual Property
    03/16/16
  5917. 36
    Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
    Albany Molecular Research
    03/14/16
  5918. 768
    Complement pathway modulators and uses thereof
    Novartis
    03/14/16
  5919. 33
    Compounds for the treatment of neurodegenerative diseases
    Proteotech
    03/14/16
  5920. 65
    Heteroaryl sodium channel inhibitors
    Amgen
    03/14/16
  5921. 30
    Nonpeptide HIV-1 protease inhibitors
    Purdue Research Foundation
    03/14/16
  5922. 396
    Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
    Amgen
    03/14/16
  5923. 17
    Pyrazinecarboxamide compound
    Astellas Pharma
    03/14/16
  5924. 172
    Spiro-oxindole MDM2 antagonists
    The Regents Of The University Of Michigan
    03/14/16
  5925. 28
    Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
    Bristol-Myers Squibb
    03/14/16
  5926. 428
    Tricyclic pyrazol amine derivatives
    Merck Serono
    03/09/16
  5927. 818
    Flap modulators
    Janssen Pharmaceutica
    03/07/16
  5928. 10
    HIV protease inhibitors
    Merck Canada
    03/07/16
  5929. 105
    Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core
    Boehringer Ingelheim International
    03/07/16
  5930. 5
    Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof
    Bayer Intellectual Property
    03/07/16
  5931. 43
    Liver X receptor modulators
    Vitae Pharmaceuticals
    03/07/16
  5932. 10
    NMDA receptor antagonists for neuroprotection
    Emory University
    03/07/16
  5933. 4
    Organic compounds
    Intra-Cellular Therapies
    03/07/16
  5934. 112
    Rho kinase inhibitors
    Boehringer Ingelheim International
    03/07/16
  5935. 1
    Selective glycosidase inhibitors and uses thereof
    Simon Fraser University
    03/07/16
  5936. 27
    Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
    Sanofi
    03/07/16
  5937. 24
    3-Oxo-2,3-dihydro-1H-indazole-4-carboxamide derivatives as PARP-1 inhibitors
    Nerviano Medical Sciences
    02/29/16
  5938. 181
    Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
    Boehringer Ingelheim International
    02/29/16
  5939. 12
    Anti-cancer compound and pharmaceutical composition containing the same
    Sanofi
    02/29/16
  5940. 10
    Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
    Albany Molecular Research
    02/29/16
  5941. 149
    Benzoic acid derivatives
    Hoffmann-La Roche
    02/29/16
  5942. 332
    Flap modulators
    Janssen Pharmaceutica
    02/29/16
  5943. 9
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    02/29/16
  5944. 25
    Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
    Boehringer Ingelheim International
    02/29/16
  5945. 54
    Pyrazole derivatives
    Hoffmann-La Roche
    02/29/16
  5946. 368
    Pyrrolo[2,3-B]pyridine CDK9 kinase inhibitors
    Abbvie
    02/29/16
  5947. 23
    Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt
    Korea Research Institute Of Chemical Technology
    02/29/16
  5948. 14
    1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
    Hoffmann-La Roche
    02/22/16
  5949. 113
    1,5-naphthyridine derivatives and MELK inhibitors containing the same
    Oncotherapy Science
    02/22/16
  5950. 19
    2-heteroaryl carboxamides
    Bayer Intellectual Property
    02/22/16
  5951. 201
    Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
    Albany Molecular Research
    02/22/16
  5952. 241
    Chemical compounds
    Pfizer
    02/22/16
  5953. 157
    Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
    Sanofi
    02/22/16
  5954. 240
    Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
    Senhwa Biosciences
    02/22/16
  5955. 47
    Hydroxamic acid derivative
    Taisho Pharmaceutical
    02/22/16
  5956. 109
    Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators
    Janssen Pharmaceutica
    02/22/16
  5957. 8
    Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same
    Chang Gung University
    02/22/16
  5958. 1
    Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes
    Boehringer Ingehleim International
    02/22/16
  5959. 215
    1,2,5-substituted benzimidazoles as FLAP modulators
    Janssen Pharmaceutica
    02/16/16
  5960. 302
    Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie Deutschland
    02/16/16
  5961. 1
    Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
    Korea Institute Of Science And Technology
    02/16/16
  5962. 107
    Fused heterocyclic derivatives and methods of use
    Amgen
    02/16/16
  5963. 2
    Inhibitors of protein kinases
    Astrazeneca
    02/16/16
  5964. 89
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    02/16/16
  5965. 20
    Pyrimidine PDE10 inhibitors
    Merck Sharp & Dohme
    02/16/16
  5966. 274
    Substituted 7-azabicyles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    02/16/16
  5967. 11
    Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors
    H. Lundbeck
    02/16/16
  5968. 79
    Tropomyosin-related kinase (TRK) inhibitors
    Genzyme
    02/16/16
  5969. 6
    2′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
    Merck Sharp & Dohme
    02/09/16
  5970. 36
    Cannabinoid-2 agonists
    Allergan
    02/09/16
  5971. 160
    Cyclohexyl-azetidinyl antagonists of CCR2
    Janssen Pharmaceutica
    02/09/16
  5972. 88
    Fused pyrimidines and substituted quinazolines as inhibitors of p97
    Cleave Biosciences
    02/09/16
  5973. 11
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    02/09/16
  5974. 2
    Management and treatment of benign prostatic hyperplasia
    Csir, Pretoria (Za
    02/09/16
  5975. 149
    Pyridine-2-derivatives as smoothened receptor modulators
    Pfizer
    02/09/16
  5976. 3
    Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof
    H. Lundbeck
    02/09/16
  5977. 92
    Triazolopyridine compounds
    Novartis
    02/09/16
  5978. 155
    Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
    Novartis
    02/09/16
  5979. 4
    Activity based probes (ABPs) interacting with glycosidases
    Academisch Medisch Centrum Bij Universiteit Van Amsterdam
    01/25/16
  5980. 18
    Apoptosis signal-regulating kinase inhibitors
    Gildead Sciences
    01/25/16
  5981. 5
    Benzomorphan analogs and the use thereof
    Purdue Pharma
    01/25/16
  5982. 27
    Heterocyclic acrylamides and their use as pharmaceuticals
    Fab Pharma
    01/25/16
  5983. 7
    Methods for treating or preventing cancer and neurodegenerative diseases
    Sloan-Kettering Institute For Cancer Research
    01/25/16
  5984. 152
    Pyridine compounds and the users thereof
    Purdue Pharma
    01/25/16
  5985. 98
    Substituted isoquinolinones and quinazolinones
    Novartis
    01/25/16
  5986. 64
    Sulfamide sodium channel inhibitors
    Amgen
    01/25/16
  5987. 10
    Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie Deutschland
    01/25/16
  5988. 8
    Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
    Merck Sharp & Dohme
    01/25/16
  5989. 51
    3,5-disubstituted alkynylbenzene compound and salt thereof
    Taiho Pharmaceutical
    01/19/16
  5990. 6
    Antimicrobial compounds
    Monash University
    01/19/16
  5991. 169
    Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Les Laboratoires Servier
    01/19/16
  5992. 2
    Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
    Incyte
    01/19/16
  5993. 1
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors
    Respivert
    01/18/16
  5994. 4
    Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors
    Novartis
    01/18/16
  5995. 85
    N-benzylindole modulators of PPARG
    The Scripps Research Institute
    01/18/16
  5996. 157
    Pyridone amides as modulators of sodium channels
    Vertex Pharmaceuticals
    01/18/16
  5997. 7
    Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
    Newron Pharmaceuticals
    01/18/16
  5998. 26
    5-HT3 receptor modulators, methods of making, and use thereof
    Albany Molecular Research
    01/11/16
  5999. 74
    Amides as modulators of sodium channels
    Vertex Pharmaceuticals
    01/11/16
  6000. 6
    Bivalent ligands for the treatment of neurological disorders
    Virginia Commonwealth University
    01/11/16
  6001. 74
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    01/11/16
  6002. 20
    Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    01/11/16
  6003. 32
    Inhibitors of beta-secretase
    Vitae Pharmaceuticals
    01/11/16
  6004. 17
    Inhibitors of the Renal Outer Medullary Potassium channel
    Merck Sharp & Dohme
    01/11/16
  6005. 28
    Selective caspase inhibitors and uses thereof
    Novagenesis Foundation
    01/11/16
  6006. 16
    Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors
    Bristol-Myers Squibb
    01/11/16
  6007. 19
    TRPA1 antagonists
    Abbvie
    01/11/16
  6008. 55
    2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
    Albany Molecular Research
    12/21/15
  6009. 9
    Biphenyl derivatives useful as glucagon receptor antagonists
    Janssen Pharmaceutica
    12/21/15
  6010. 6
    Compounds and methods useful for directing stem cell differentiation
    Vanderbilt University
    12/21/15
  6011. 15
    Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
    Kissei Pharmaceutical
    12/21/15
  6012. 18
    Histone deacetylase inhibitor of benzamides and use thereof
    Shanghai Institute Of Pharmaceutical Industry
    12/21/15
  6013. 40
    Hydroxymethylaryl-substituted pyrrolotriazines as ALK1 inhibitors
    Bayer Intellectual Property
    12/21/15
  6014. 137
    IRE-1α inhibitors
    Mannkind
    12/21/15
  6015. 13
    Inhibition of small ubiquitin-like modifier enzymes with substituted pyrrolo[2,3-b]quinoxalines
    City Of Hope
    12/21/15
  6016. 3
    Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie Deutschland
    12/21/15
  6017. 6
    Pyrazole-amide compounds and pharmaceutical use thereof
    Japan Tobacco
    12/21/15
  6018. 72
    Chemical compounds
    Glaxosmithkline
    12/14/15
  6019. 190
    Chemical compounds 542
    Astrazeneca
    12/14/15
  6020. 5
    Compositions and methods for treating cancer
    Otsuka Pharmaceutical
    12/14/15
  6021. 116
    Melanocortin receptor-specific peptides
    Astrazeneca
    12/14/15
  6022. 3
    Method of treating human skin and a skin care composition for use in such a method
    Pantarhei Bioscience
    12/14/15
  6023. 143
    Nitrogen-containing condensed heterocyclic compound
    Taisho Pharmaceutical
    12/14/15
  6024. 42
    Pyrrolo[2,3-D]pyrimidine derivatives
    Pfizer
    12/14/15
  6025. 1
    Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
    Vertex Pharmaceuticals
    12/14/15
  6026. 90
    [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
    Janssen Pharmaceutica
    12/14/15
  6027. 202
    Diphenylmethane derivatives as SGLT2 inhibitors
    Green Cross
    12/08/15
  6028. 3
    Method of using 4,5,6,7-tetrahydroimidazo[4,5-C]pyridine compounds
    Proximagen
    12/08/15
  6029. 3
    Process for preparing a compound useful for producing an optically active diazabicyclooctane compound
    Meiji Seika Pharma
    12/08/15
  6030. 14
    17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative
    Bayer Intellectual Property
    12/07/15
  6031. 5
    4-aminoquinazoline derivatives and uses thereof
    Shanghai Institute Of Pharmaceutical Industry
    12/07/15
  6032. 12
    Agents for reversing epigenetic silencing of genes
    The Johns Hopkins University
    12/07/15
  6033. 26
    Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
    Albany Molecular Research
    12/07/15
  6034. 10
    Carbamate/urea derivatives
    Novartis
    12/07/15
  6035. 44
    Indanyl-substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
    Sanofi
    12/07/15
  6036. 36
    Inhibitors of glutaminyl cyclase
    Probiodrug
    12/07/15
  6037. 608
    Tricyclic compounds and methods of use therefor
    Genentech
    12/07/15
  6038. 50
    17α-hydroxylase/C17,20-lyase inhibitors
    Novartis
    11/23/15
  6039. 17
    2,5-disubstituted thiomorpholine orexin receptor antagonists
    Merck Sharp & Dohme
    11/23/15
  6040. 22
    Adenosine receptor ligands and uses thereof
    Kaldi Pharma
    11/23/15
  6041. 32
    Cyclopropyl amide derivatives
    Astrazeneca
    11/23/15
  6042. 10
    Iminothiadiazine dioxide compounds as brace inhibitors, compositions, and their use
    Merck Sharp & Dohme
    11/23/15
  6043. 5
    Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof
    TBA
    11/23/15
  6044. 3
    Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy
    Pantarhei Bioscience
    11/23/15
  6045. 30
    Sorafenib derivatives as sEH inhibitors
    The Regents Of The University Of California
    11/23/15
  6046. 138
    Substituted benzamide derivatives
    Hoffmann-La Roche
    11/23/15
  6047. 2
    γ-Secretase substrates and methods of use
    Memorial Sloan-Kettering Cancer Center
    11/16/15
  6048. 212
    5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same
    Kissei Pharmaceutical
    11/16/15
  6049. 5
    BACE inhibitors
    Eli Lilly
    11/16/15
  6050. 655
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    11/16/15
  6051. 81
    Heteroarylcarboxylic acid ester derivative
    Ajinomoto
    11/16/15
  6052. 19
    Pyrazolopyrimidines as metabotropic glutamate 5 receptor antagonists
    Boehringer Ingelheim International
    11/16/15
  6053. 22
    Substituted fused imidazoles and pyrazoles and use thereof
    Bayer Intellectual Property
    11/16/15
  6054. 4
    Substituted indazole derivatives active as kinase inhibitors
    Nerviano Medical Sciences
    11/16/15
  6055. 15
    Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
    Fm Therapeutics
    11/11/15
  6056. 32
    Chemical compounds
    Astrazeneca
    11/11/15
  6057. 42
    Combination therapy with MDM2 and EFGR inhibitors
    TBA
    11/11/15
  6058. 124
    Phenylimidazole derivatives as PDE10A enzyme inhibitors
    H. Lundbeck
    11/11/15
  6059. 500
    Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
    Sanofi
    11/11/15
  6060. 6
    Alicyclic[c] benzopyrone derivatives and uses thereof
    Huazhong University Of Science & Technology
    11/02/15
  6061. 217
    Bicyclic heterocycle compounds and their uses in therapy
    Astex Therapeutics
    11/02/15
  6062. 20
    Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
    The Board Of Trustees Of The Leland Stanford Junior University
    11/02/15
  6063. 7
    Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system
    Instytut Chemii Organicznej Polskiej Akademii Nauk
    11/02/15
  6064. 38
    FAK inhibitors
    Cancer Therapeutics Crc
    11/02/15
  6065. 7
    Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof
    Bayer Intellectual Property
    11/02/15
  6066. 16
    Inhibitors of beta-secretase
    Boehringer Ingelheim International
    11/02/15
  6067. 9
    Inhibitors of the renal outer medullary potassium channel
    Merck Sharp & Dohme
    11/02/15
  6068. 13
    Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor
    Taiho Pharmaceutical
    11/02/15
  6069. 291
    TRPV3 modulators
    Abbvie
    11/02/15
  6070. 19
    Azetidine derivatives
    Vernalis (R&D
    10/26/15
  6071. 110
    Dihydroorotate dehydrogenase inhibitors
    Merck Serono
    10/26/15
  6072. 7
    Liver X receptor modulators
    Vitae Pharmaceuticals
    10/26/15
  6073. 6
    Methods of modifying amyloid β oligomers using non-peptidic compounds
    Acumen Pharmaceuticals
    10/26/15
  6074. 10
    Prolylcarboxypeptidase inhibitors
    Merck Sharp & Dohme
    10/26/15
  6075. 98
    Pyrimidone derivatives
    Mitsubishi Tanabe Pharma
    10/26/15
  6076. 20
    Rosuvastatin and atorvastatin derivatives
    Redx Pharma
    10/26/15
  6077. 13
    Substituted aminobutyric derivatives as neprilysin inhibitors
    Novartis
    10/26/15
  6078. 3
    Substituted benzene compounds
    Epizyme
    10/26/15
  6079. 15
    Tetrahydrocarboline derivative
    Ono Pharmaceutical
    10/26/15
  6080. 24
    2H-imidazol-4-amine compounds and their use as BACE inhibitors
    Astrazeneca
    10/19/15
  6081. 10
    Cycloalkyl ether compounds and their use as BACE inhibitors
    Astrazeneca
    10/19/15
  6082. 12
    Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors
    Astrazeneca
    10/19/15
  6083. 17
    Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
    Astrazeneca
    10/19/15
  6084. 315
    Heterocyclic compounds as ERK inhibitors
    Merck Sharp & Dohme
    10/19/15
  6085. 43
    Imidazo[4,5-c]quinolines as DNA-PK inhibitors
    Merck Patent
    10/19/15
  6086. 1
    Phenoxyethoxy compounds
    Eli Lilly
    10/19/15
  6087. 59
    Proline sulfonamide derivatives as orexin receptor antagonists
    Actelion Pharmaceuticals
    10/19/15
  6088. 61
    Substituted naphthylacetic acids
    Hoffmann-La Roche
    10/19/15
  6089. 34
    Thiophene derivative as SGLT2 inhibitor and pharmaceutical composition comprising same
    Green Cross
    10/19/15
  6090. 240
    3-amido-pyrrolo[3,4-C]pyrazole-5(1H, 4H,6H) carbaldehyde derivatives
    Pfizer
    10/12/15
  6091. 500
    Bicyclic aryl and heteroaryl sodium channel inhibitors
    Amgen
    10/12/15
  6092. 5
    Amides of acetic and propionic acids
    Bayer Intellectual Property
    10/05/15
  6093. 14
    Compounds for the treatment of addiction
    Gilead Sciences
    10/05/15
  6094. 9
    Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases
    Consejo Superior De Investigaciones Cientificas
    10/05/15
  6095. 19
    Oxazine derivatives
    Shionogi
    10/05/15
  6096. 16
    Pharmaceutically active compounds as Axl inhibitors
    Lead Discovery Center
    10/05/15
  6097. 65
    Phenylcyclopropylamine derivatives and their medical use
    Oryzon Genomics
    10/05/15
  6098. 24
    Pyrazolopyrimidine JAK inhibitor compounds and methods
    Genentech
    10/05/15
  6099. 138
    Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C
    Boehringer Ingelheim International
    10/05/15
  6100. 5
    Tetrahydrocyclopenta[c]acridine derivatives as kinase inhibitors and biological
    Centre National De La Recherche Scientifique
    10/05/15
  6101. 113
    (aza)indole derivative and use thereof for medical purposes
    Kissei Pharmaceutical
    09/28/15
  6102. 3
    4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics
    Galderma Research & Development
    09/28/15
  6103. 42
    Method of treating contrast-induced nephropathy
    Novartis
    09/28/15
  6104. 10
    Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
    Rhizen Pharmaceuticals
    09/28/15
  6105. 5
    Morpholinyl derivatives useful as MOGAT-2 inhibitors
    Eli Lilly
    09/28/15
  6106. 124
    N1/N2-lactam acetyl-CoA carboxylase inhibitors
    Pfizer
    09/28/15
  6107. 112
    Pyrrolopyrimidines as janus kinase inhibitors
    Merck Sharp & Dohme
    09/28/15
  6108. 48
    Substituted pyrrolidine-2-carboxamides
    F. Hoffmann-La Roche
    09/28/15
  6109. 26
    Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
    Albany Molecular Research
    09/28/15
  6110. 6
    [1,3,4] oxadiazole derivative and application thereof
    Huazhong University Of Science & Technology
    09/28/15
  6111. 153
    (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
    Sanofi
    09/03/15
  6112. 64
    Compositions and methods for treatment of leukemia
    University Of Michigan
    09/03/15
  6113. 124
    Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs
    University Of South Florida
    09/03/15
  6114. 10
    Pyridinedione carboxamide inhibitors of endothelial lipase
    Bristol-Myers Squibb
    09/03/15
  6115. 18
    Resorcinol derivatives as HSP90 inhibitors
    Nerviano Medical Sciences
    09/03/15
  6116. 72
    Ring-fused compound
    Sato Pharmaceutical
    09/03/15
  6117. 202
    Ring-substituted N-pyridinyl amides as kinase inhibitors
    Novartis
    09/03/15
  6118. 37
    Selective androgen receptor modulators
    Radius Health
    09/03/15
  6119. 26
    Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
    University Of Utah Research Foundation
    09/03/15
  6120. 180
    Sulfonamide compounds having TRPM8 antagonistic activity
    Mitsubishi Tanabe Pharma
    09/03/15
  6121. 375
    Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase
    Bristol-Myers Squibb
    08/25/15
  6122. 3
    Compounds and method for treatment of HIV
    Critical Outcome Technologies
    08/25/15
  6123. 38
    Heterocyclic derivatives
    Novartis
    08/25/15
  6124. 17
    Inhibitors of cytochrome P450
    Gilead Sciences
    08/25/15
  6125. 5
    Metalloenzyme inhibitor compounds
    Innocrin Pharmaceuticals
    08/25/15
  6126. 177
    Pyrimidinecarboxamides as CXCR2 modulators
    Syntrix Biosystems
    08/25/15
  6127. 60
    Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
    Bristol-Myers Squibb
    08/25/15
  6128. 12
    Spirocyclic morphinans and their use
    Purdue Pharma
    08/25/15
  6129. 38
    Substituted imidazo[1,2-B]pyridazines
    Bayer Intellectual Property
    08/25/15
  6130. 45
    Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway
    Bayer Intellectual Property
    08/25/15
  6131. 10
    19-nor-steroid derivatives with a 15α,16α-methylene group and a saturated 17,17-spirolactone ring, use thereof, and medicaments containing said derivatives
    Bayer Intellectual Property Gbmh
    08/19/15
  6132. 7
    CXCR2 inhibitors
    Sanofi
    08/19/15
  6133. 10
    Cancer targeting using carbonic anhydrase isoform IX inhibitors
    Maastro-Clinic
    08/19/15
  6134. 25
    Inhibitors of β-secretase
    Vitae Pharmaceuticals
    08/19/15
  6135. 1
    Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders
    Janssen Pharmaceutica
    08/19/15
  6136. 15
    Morpholinone compounds as factor IXA inhibitors
    Merck Sharp & Dohme
    08/19/15
  6137. 357
    Substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
    Boehringer Ingelheim International
    08/19/15
  6138. 13
    Substituted cis- and trans-stilbenes as therapeutic agents
    Stc.Unm
    08/19/15
  6139. 25
    Substituted piperidines as Par-1 antagonists
    Bayer Intellectual Property
    08/19/15
  6140. 8
    Tetrahydropyrrolothiazine compounds
    Eli Lilly
    08/19/15
  6141. 7
    2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof
    Toxicology Academy Of Military Medical Sciences P.L.A.
    08/10/15
  6142. 5
    5-fluoro-3-phenyl-2[1-(9H-purin-6-ylamino)propyl]-3H-quinazolin-4-one and 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as inhibitors of human phosphatidylinositol 3-kinase delta
    Icos
    08/10/15
  6143. 25
    Aryl glycoside compound, preparation method and use thereof
    Shanghai Yingli Science And Technology
    08/10/15
  6144. 10
    Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
    Leo Pharma
    08/10/15
  6145. 211
    Chromane compounds
    Comentis
    08/10/15
  6146. 3
    Factor IXa inhibitors
    Merck Sharp & Dohme
    08/10/15
  6147. 18
    Heterocyclic substituted pyrimidine compound
    Xuanzhu Pharma
    08/10/15
  6148. 9
    Phenyl derivative
    Ono Pharmaceutical
    08/10/15
  6149. 189
    Pyrazolopyrrolidine derivatives and their use in the treatment of disease
    Novartis
    08/10/15
  6150. 27
    Pyridonemorphinan analogs and biological activity on opioid receptors
    Purdue Pharma
    08/10/15
  6151. 13
    Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
    Merck Sharp & Dohme
    08/10/15
  6152. 13
    5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases
    Sanofi
    08/03/15
  6153. 14
    Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors
    Merck Sharp & Dohme
    08/03/15
  6154. 45
    Heterocyclic compounds and uses thereof
    Celgene Avilomics Research
    08/03/15
  6155. 8
    Inhibitors of PDE10
    Bristol-Myers Squibb
    08/03/15
  6156. 19
    Inhibitors of glutaminyl cyclase
    Probiodrug
    08/03/15
  6157. 27
    Methods and compositions of treating a flaviviridae family viral infection
    The Board Of Trustees Of The Leland Stanford Junion University
    08/03/15
  6158. 2
    Morpholine derivative
    Shanghai Pharmaceuticals Holding
    08/03/15
  6159. 12
    Pyridazinones, method of making, and method of use thereof
    Genetech
    08/03/15
  6160. 189
    Substituted imidazo[1,2-a]pyrimidines and —pyridines
    Bayer Intellectual Property
    08/03/15
  6161. 4
    Substituted pyrazolone compounds and methods of use
    Sunshine Lake Pharma
    08/03/15
  6162. 17
    Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
    Nerviano Medical Sciences
    08/03/15
  6163. 42
    Bicyclic compounds and their uses as dual c-SRC/JAK inhibitors
    Debiopharm
    07/22/15
  6164. 8
    Compounds for the treatment of hepatitis C
    Bristol-Myers Squibb
    07/22/15
  6165. 92
    Curcumin derivative
    Tokyo Institute Of Technology
    07/22/15
  6166. 24
    Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics
    Pierre Fabre Medicament
    07/22/15
  6167. 13
    Peripherally acting opioid compounds
    Alkermes
    07/22/15
  6168. 1
    Phenoxyethyl piperidine compounds
    Eli Lilly
    07/22/15
  6169. 483
    Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    07/22/15
  6170. 97
    Pyrrolopyrimidine compounds and their uses
    Novartis
    07/22/15
  6171. 3
    Selective glycosidase inhibitors and uses thereof
    Simon Fraser University
    07/22/15
  6172. 11
    Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
    Amgen
    07/22/15
  6173. 223
    Tricyclic compounds and PBK inhibitors containing the same
    Oncotherapy Science
    07/22/15
  6174. 5
    7,8-cyclicmorphinan analogs
    Purdue Pharma
    07/15/15
  6175. 12
    Acetic acid amide derivative having inhibitory activity on endothelial lipase
    Shionogi
    07/15/15
  6176. 5
    Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
    Johannes Gutenberg—Universitat Mainz
    07/15/15
  6177. 563
    Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
    Merck Sharp & Dohme
    07/15/15
  6178. 22
    Heterocyclic substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    07/15/15
  6179. 261
    N-biphenylmethylindole modulators of PPARG
    The Scripps Research Institute
    07/15/15
  6180. 72
    Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them
    Domainex
    07/15/15
  6181. 270
    Substituted imidazopyridines as HDM2 inhibitors
    Merck Sharp & Dohme
    07/15/15
  6182. 20
    Substituted imidazopyridinyl-aminopyridine compounds
    Arqule
    07/15/15
  6183. 20
    Tetrahydroisoquinoline derivative
    Astellas Pharma
    07/15/15
  6184. 26
    O-GlcNAc transferase inhibitors and uses thereof
    President And Fellows Of Harvard College
    07/10/15
  6185. 14
    Pyrazolopyrimidine PDE 10 inhibitors
    Merck Sharp & Dohme
    07/10/15
  6186. 144
    Pyrrolopyrimidine compounds as inhibitors of CDK4/6
    Novartis
    07/10/15
  6187. 29
    Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
    Amgen
    07/10/15
  6188. 504
    3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
    Novartis
    07/09/15
  6189. 91
    Fused pyrimidines
    Bayer Intellectual Property
    07/09/15
  6190. 66
    Modulators of serotonin receptors
    Janssen Pharmaceutica
    07/09/15
  6191. 372
    Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors
    Amgen
    07/09/15
  6192. 1
    Use of azaphilone compounds for the modulation of the activity of a nuclear hormone receptor
    Food Industry Research And Development Institute
    07/09/15
  6193. 177
    1,2,6-substituted benzimidazoles as FLAP modulators
    Janssen Pharmaceutica
    06/29/15
  6194. 404
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    06/29/15
  6195. 5
    Benzoic acid derivative MDM2 inhibitor for the treatment of cancer
    Amgen
    06/29/15
  6196. 93
    Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors
    Amgen
    06/29/15
  6197. 22
    Imaging diagnostic agent and extracorporeal diagnostic agent for incurable neurological diseases
    Shiga University Of Medical Science
    06/29/15
  6198. 3
    Inhibitors of syk and JAK protein kinases
    Portola Pharmaceuticals
    06/29/15
  6199. 3
    Multifunctional radical quenchers and their uses
    Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University
    06/29/15
  6200. 407
    N-substituted benzamides and methods of use thereof
    Xenon Pharmaceuticals
    06/29/15
  6201. 28
    Prostaglandin transporter inhibitors and uses thereof
    Albert Einstein College Of Medicine Of Yeshiva University
    06/29/15
  6202. 49
    Somatostatin-dopamine chimeric analogs
    Ipsen Pharma
    06/29/15
  6203. 29
    3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors
    Allergan
    06/22/15
  6204. 3
    Aminoheteroaryl compounds and preparation method and use thereof
    Shanghai Allist Pharmaceuticals
    06/22/15
  6205. 38
    Buprenorphine analogs
    Purdue Pharma
    06/22/15
  6206. 50
    Chemical compounds
    Pfizer
    06/22/15
  6207. 10
    Chymase inhibitors
    Boehringer Ingelheim International
    06/22/15
  6208. 50
    Diamino heterocyclic carboxamide compound
    Astellas Pharma
    06/22/15
  6209. 13
    Inhibitors of STAT3
    University Of Central Florida Research Foundation
    06/22/15
  6210. 43
    Pyrazolopyrimidine compounds and their use as PDE10 inhibitors
    Mitsubishi Tanabe Pharma
    06/22/15
  6211. 18
    Substituted bicyclic heteroaryl compounds
    Bristol-Myers Squibb
    06/22/15
  6212. 115
    Substituted naphthyridines and their use as medicaments
    Boehringer Ingelheim Pharma
    06/22/15
  6213. 6
    Therapeutic compositions and methods
    The Penn State Research Foundation
    06/22/15
  6214. 24
    Thiophenecarboxamide derivatives as EP4 receptor ligands
    Merck Frosst Canada
    06/22/15
  6215. 95
    Benzonitrile derivatives as kinase inhibitors
    Merck Patent
    06/16/15
  6216. 187
    Compound of a reverse-turn mimetic and a production method and use therefor
    Jw Pharmaceutical
    06/16/15
  6217. 17
    Heteroaromatic compounds as BTK inhibitors
    Boehringer Ingelheim International
    06/16/15
  6218. 11
    Iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme
    06/16/15
  6219. 77
    Macrocycles as factor XIa inhibitors
    Bristol-Myers Squibb
    06/16/15
  6220. 29
    Organic compounds
    Novartis
    06/16/15
  6221. 33
    Pyrazolopyrimidine compounds as kinase inhibitors
    Principia Biopharma
    06/16/15
  6222. 199
    Pyrazolopyrrolidine compounds
    Novartis
    06/16/15
  6223. 47
    Substituted 2-azabicycles and their use as orexin receptor modulators
    Janssen Pharmaceutica
    06/16/15
  6224. 331
    TRPV1 antagonists
    Abbvie
    06/16/15
  6225. 4
    Inhibitors of protein kinases
    Portola Pharmaceuticals
    06/15/15
  6226. 19
    17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivative, use thereof, and medicament containing the derivative
    TBA
    06/08/15
  6227. 6
    Anticancer compounds
    Boehringer Ingelheim International
    06/08/15
  6228. 12
    Apogossypolone derivatives as anticancer agents
    Sanford-Burnham Medical Research Institute
    06/08/15
  6229. 22
    Aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
    Gruenenthal
    06/08/15
  6230. 71
    Imidazotriazinecarbonitriles useful as kinase inhibitors
    Bristol-Myers Squibb
    06/08/15
  6231. 16
    Lithocholic acid analogues that inhibit sialyltransferase
    Academia Sinica
    06/08/15
  6232. 15
    Nitrogen containing morphinan derivatives and the use thereof
    Purdue Pharma
    06/08/15
  6233. 51
    Pyridopyrazine derivatives and their use
    Zentaris
    06/08/15
  6234. 11
    Pyrimidone compounds
    Mitsubishi Tanabe Pharma
    06/08/15
  6235. 36
    Respiratory formulations and compounds for use therein
    Respivert
    06/08/15
  6236. 169
    Triazine derivatives
    Pfizer
    06/08/15
  6237. 26
    2-arylimidazole derivatives as PDE10A enzyme inhibitors
    H. Lundbeck
    06/01/15
  6238. 22
    Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
    Sanofi
    06/01/15
  6239. 1
    Dimethyl-benzoic acid compounds
    Eli Lilly
    06/01/15
  6240. 29
    Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    06/01/15
  6241. 8
    Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
    Northwestern University
    06/01/15
  6242. 29
    KAT II inhibitors
    Pfizer
    06/01/15
  6243. 1
    Kinase inhibitor
    Respivert
    06/01/15
  6244. 128
    Monocyclic pyridine derivative
    Eisai R&D Management
    06/01/15
  6245. 119
    Pyridone and pyridazinone derivatives as anti-obesity agents
    Boehringer Ingelheim International
    06/01/15
  6246. 23
    Quinolinyl glucagon receptor modulators
    Pfizer
    06/01/15
  6247. 7
    Selective glycosidase inhibitors and uses thereof
    TBA
    06/01/15
  6248. 27
    Soft protease inhibitors and pro-soft forms thereof
    Trustees Of Tufts College
    06/01/15
  6249. 53
    4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2
    Janssen Pharmaceutica
    05/26/15
  6250. 3
    Antibacterial compounds
    Institut Curie
    05/26/15
  6251. 88
    Benzofurane-piperidine compounds
    Hoffmann-La Roche
    05/26/15
  6252. 16
    C-aryl ansa SGLT2 inhibitors
    Green Cross
    05/26/15
  6253. 12
    Compounds for the inhibition of integrins and use thereof
    Shire Orphan Therapies
    05/26/15
  6254. 10
    Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
    Vitae Pharmaceuticals
    05/26/15
  6255. 13
    Histone deacetylase inhibitors, process for preparation and uses thereof
    Zhejiang Hisun Pharmaceutical
    05/26/15
  6256. 2
    Inhibitors of dimethylarginine dimethylaminohydrolase
    Christian-Albrechts-Universitaet Zu Kiel
    05/26/15
  6257. 217
    Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase
    Fibrogen
    05/26/15
  6258. 79
    Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes
    Targacept
    05/26/15
  6259. 8
    Selective glycosidase inhibitors and uses thereof
    TBA
    05/26/15
  6260. 14
    Tetrahydrothiazepine derivative
    Daiichi Sankyo
    05/26/15
  6261. 9
    2,3-dihydro-1H-indene-2-yl urea derivative and pharmaceutical application of same
    Toray Industries
    05/18/15
  6262. 25
    5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity
    Shionogi
    05/18/15
  6263. 9
    Azole derivatives in the form of lipase and phospholipase inhibitors
    Sanofi
    05/18/15
  6264. 10
    Bicyclo[3.2.1]octyl amide derivatives and uses of same
    H. Lundbeck
    05/18/15
  6265. 22
    Compounds having TRPV1 antagonistic activity and uses thereof
    Shionogi
    05/18/15
  6266. 5
    Dibenzothiazepine derivatives and uses thereof—424
    Astrazeneca
    05/18/15
  6267. 56
    Modulators of calcium release-activated calcium channel
    Rhizen Pharmaceuticals
    05/18/15
  6268. 17
    Phenyl and benzodioxinyl substituted indazoles derivatives
    Astrazeneca
    05/18/15
  6269. 53
    Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
    Bristol-Myers Squibb
    05/18/15
  6270. 15
    Serine protease inhibitors
    The Medicines Company (Leipzig
    05/18/15
  6271. 180
    Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
    Abbvie
    05/18/15
  6272. 16
    Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
    Nerviano Medical Sciences
    05/18/15
  6273. 4
    (4-{4-[5-(benzooxazol-2-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid useful for treating or preventing conditions or disorders associated with DGAT1 activity
    Novartis
    05/11/15
  6274. 6
    4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
    Qilu Pharmaceutical
    05/11/15
  6275. 10
    Aryl sulfamide and sulfamate derivatives as RORc modulators
    Genentech
    05/11/15
  6276. 44
    Biaryl amide derivatives
    Hoffmann-La Roche
    05/11/15
  6277. 115
    Bicyclic compound or salt thereof
    Taiho Pharmaceutical
    05/11/15
  6278. 8
    Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
    Merck Sharp & Dohme
    05/11/15
  6279. 51
    Pharmacokinetically improved compounds
    Surface Logix
    05/11/15
  6280. 360
    Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals
    Sanofi
    05/11/15
  6281. 119
    Substituted quinolines and their use as medicaments
    Boehringer Ingelheim International
    05/11/15
  6282. 45
    Sulfonamide compounds useful as CYP17 inhibitors
    Bristol-Myers Squibb
    05/11/15
  6283. 12
    Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
    Purdue Research Foundation
    05/11/15
  6284. 10
    Synthetic compounds and methods to decrease nicotine self-administration
    TBA
    05/11/15
  6285. 94
    1H-imidazo[4,5-c]quinolines
    Boehringer Ingelheim International
    05/04/15
  6286. 7
    6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof
    Jiangsu Hengrui Medicine
    05/04/15
  6287. 17
    Bicyclic heterocyclic compounds as FGFR inhibitors
    Astex Therapeutics
    05/04/15
  6288. 68
    Chemokine receptor antagonists
    Abbvie
    05/04/15
  6289. 38
    Compounds as cannabinoid receptor ligands
    Abbvie
    05/04/15
  6290. 24
    Cyclic P1 linkers as factor XIa inhibitors
    Bristol-Myers Squibb
    05/04/15
  6291. 20
    Dihydropyrimidin-2(1H)-one compounds as neurokinin-3 receptor antagonists
    N30 Pharmaceuticals
    05/04/15
  6292. 16
    Inhibitors of cyclophilins and uses thereof
    University Of Montpellier
    05/04/15
  6293. 39
    Selective glycosidase inhibitors and uses thereof
    Merck Sharp & Dohme
    05/04/15
  6294. 165
    Thienopyrazole derivative having PDE7 inhibitory activity
    Daiichi Sankyo
    05/04/15
  6295. 14
    Tricyclic compounds, compositions, and methods
    Pfizer
    05/04/15
  6296. 138
    Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
    Acetylon Pharmaceuticals
    05/03/15
  6297. 35
    Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Bayer Intellectual Property
    04/27/15
  6298. 10
    Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
    Boehringer Ingelheim International
    04/27/15
  6299. 77
    Compounds and methods for treating bacterial infections
    Astrazeneca
    04/27/15
  6300. 26
    Compounds, formulations, and methods of protein kinase C inhibition
    University Of Michigan
    04/27/15
  6301. 11
    Glycoside derivatives and uses thereof
    Novartis
    04/27/15
  6302. 28
    Indazoles
    Pfizer
    04/27/15
  6303. 2
    Inhibitors of human EZH2 and methods of use thereof
    Epizyme
    04/27/15
  6304. 88
    Kinase inhibitors
    Allergan
    04/27/15
  6305. 57
    PARP inhibitor compounds, compositions and methods of use
    Eisai
    04/27/15
  6306. 30
    Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
    Boehringer Ingelheim International
    04/27/15
  6307. 2
    Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
    Temple University
    04/27/15
  6308. 7
    Tetrazole compounds for reducing uric acid
    Wellstat Therapeutics
    04/27/15
  6309. 2
    1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment
    Gilead Sciences
    04/20/15
  6310. 21
    2-heteroarylcarboxylic acid amides
    Bayer Intellectual Property
    04/20/15
  6311. 20
    Anti-tumor effect potentiator
    Taiho Pharmaceutical
    04/20/15
  6312. 15
    Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
    Abbvie
    04/20/15
  6313. 50
    Bivalent inhibitors of IAP proteins and therapeutic methods using the same
    The Regents Of The University Of Michigan
    04/20/15
  6314. 82
    Cyclohexyl amide derivatives and their use as CRF-1 receptor antagonists
    Novartis
    04/20/15
  6315. 4
    Metalloenzyme inhibitor compounds
    Viamet Pharmaceuticals
    04/20/15
  6316. 31
    Oxadiazole diaryl compounds
    Merck Serono
    04/20/15
  6317. 478
    Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    04/20/15
  6318. 15
    Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Nerviano Medical Sciences
    04/20/15
  6319. 4
    Synthesis of bicyclic compounds and method for their use as therapeutic agents
    Uvic Industry Partnerships
    04/20/15
  6320. 26
    1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
    Neurovance
    04/13/15
  6321. 53
    3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors
    Nerviano Medical Sciences
    04/13/15
  6322. 95
    Benzofurane compounds
    Hoffmann-La Roche
    04/13/15
  6323. 13
    Compositions and methods for inhibition of cathepsins
    Oxigene
    04/13/15
  6324. 74
    Fused bicyclic oxazolidinone CETP inhibitor
    Merck Sharp & Dohme
    04/13/15
  6325. 33
    Identification of stabilizers of multimeric proteins
    The Board Of Trustees Of The Leland Stanford Junior University
    04/13/15
  6326. 8
    Inhibitors of pyruvate kinase and methods of treating disease
    Beth Israel Deaconess Medical Center
    04/13/15
  6327. 28
    Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
    Georgia Tech Research
    04/13/15
  6328. 7
    Pyrazine derivatives and use as PI3K inhibitors
    Merck Serono
    04/13/15
  6329. 25
    Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
    Boehringer Ingelheim International
    04/13/15
  6330. 7
    Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
    Novartis
    04/13/15
  6331. 22
    Substituted pyrimidine compounds and their use as SYK inhibitors
    Genosco
    04/13/15
  6332. 153
    Compounds and their use as BACE inhibitors
    Astrazeneca
    04/06/15
  6333. 4
    Depsipeptides and their therapeutic use
    Karus Therapeutics
    04/06/15
  6334. 653
    Fluorene compound and pharmaceutical use thereof
    Japan Tobacco
    04/06/15
  6335. 30
    Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    Pfizer
    04/06/15
  6336. 472
    Heterocyclic modulators of lipid synthesis
    3-V Biosciences
    04/06/15
  6337. 5
    Macrolides and their use
    Basilea Pharmaceutica
    04/06/15
  6338. 105
    Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds
    Array Biopharma
    04/06/15
  6339. 35
    Piperazine compound capable of inhibiting prostaglandin D synthase
    Taiho Pharmaceutical
    04/06/15
  6340. 11
    Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer'S disease
    Merck Sharp & Dohme
    04/06/15
  6341. 26
    Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin C
    Boehringer Ingelheim International
    04/06/15
  6342. 143
    Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
    Array Biopharma
    04/06/15
  6343. 8
    Tetracycline compounds as tyrosyl-DNA phosphodiesterase I inhibitors
    The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
    04/06/15
  6344. 53
    2-carboxamide-7-piperazinyl-benzofuran derivatives
    Acturum Life Science
    03/16/15
  6345. 31
    Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
    Industrial Research
    03/16/15
  6346. 64
    Compounds as cannabinoid receptor ligands
    Abbvie
    03/16/15
  6347. 32
    Cyclohexyl isoquinolinone compounds
    Novartis
    03/16/15
  6348. 17
    Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
    Takeda Pharmaceutical
    03/16/15
  6349. 185
    Diazepinone derivatives
    Novartis
    03/16/15
  6350. 9
    Methotrexate adjuvants to reduce toxicity and methods for using the same
    Tosk
    03/16/15
  6351. 4
    Small molecule inhibitors of RGS proteins
    University Of Michigan
    03/16/15
  6352. 16
    Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
    Merck Sharp & Dohme
    03/16/15
  6353. 165
    Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
    Boehringer Ingelheim International
    03/16/15
  6354. 11
    Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
    Sanofi
    03/16/15
  6355. 13
    Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
    High Point Pharmaceuticals
    03/16/15
  6356. 197
    C-linked hydroxamic acid derivatives useful as antibacterial agents
    Pfizer
    03/09/15
  6357. 26
    Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
    University Of Connecticut
    03/09/15
  6358. 6
    Heterocyclic pyrazole compounds, method for preparing the same and use thereof
    Development Center For Biotechnology
    03/09/15
  6359. 126
    Melanocortin receptor-specific peptides
    Palatin Technologies
    03/09/15
  6360. 18
    Nitrogenous-ring acylguanidine derivative
    Astellas Pharma
    03/09/15
  6361. 180
    Oxazine derivatives and their use in the treatment of neurological disorders
    Novartis
    03/09/15
  6362. 506
    Pyrrolo[2,3-d]pyrimidine tropomysin-related kinase inhibitors
    Pfizer
    03/09/15
  6363. 35
    Radiolabeled PDE10 inhibitors
    Merck Sharp & Dohme
    03/09/15
  6364. 282
    Substituted imidazopyridines as HDM2 inhibitors
    Merck Sharp & Dohme
    03/09/15
  6365. 143
    Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
    Novartis
    03/09/15
  6366. 8
    Therapeutic applications in the cardiovascular field of quinazolinedione derivatives
    Sanofi
    03/09/15
  6367. 38
    Azaindazoles as kinase inhibitors and use thereof
    Bristol-Myers Squibb
    03/03/15
  6368. 65
    Compounds as cannabinoid receptor ligands
    Abbvie
    03/03/15
  6369. 28
    Heterocyclic acrylamides and their use as pharmaceuticals
    Fab Pharma
    03/03/15
  6370. 371
    Isoxazolo-pyridine derivatives
    Roche Palo Alto
    03/03/15
  6371. 8
    N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
    Abbvie
    03/03/15
  6372. 10
    Purine derivatives
    Cyclacel
    03/03/15
  6373. 511
    Pyrazole compound and pharmaceutical use thereof
    Japan Tobacco
    03/03/15
  6374. 170
    Quinazoline derivatives as a multiplex inhibitor and method for the preparation thereof
    Hanmi Pharm.
    03/03/15
  6375. 29
    Seven-membered ring compound and pharmaceutical use therefor
    Daiichi Sankyo
    03/03/15
  6376. 211
    Substituted pyrimidines for the treatment of diseases such as cancer
    Boehringer Ingelheim International
    03/03/15
  6377. 250
    Substituted-quinoxaline-type piperidine compounds and the uses thereof
    Purdue Pharma
    03/03/15
  6378. 60
    Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same
    Green Cross
    02/23/15
  6379. 2
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    02/23/15
  6380. 1
    Compounds useful as inhibitors of ATR kinase
    Vertex Pharmaceuticals
    02/23/15
  6381. 28
    Cyclohexyl amide derivatives as CRF receptor antagonists
    Novartis
    02/23/15
  6382. 40
    Dihydrofolate reductase inhibitors
    Trius Therapeutics
    02/23/15
  6383. 480
    Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
    Amgen
    02/23/15
  6384. 18
    Hybrid cholinesterase inhibitors
    Uniwersytet Warszawski
    02/23/15
  6385. 146
    Inhibitors of CYP 17
    Novartis
    02/23/15
  6386. 10
    Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
    Universtà
    02/23/15
  6387. 165
    Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cFMS inhibitors
    Array Biopharma
    02/23/15
  6388. 50
    Triazole compounds that modulate HSP90 activity
    Synta Pharmaceuticals
    02/23/15
  6389. 663
    Compounds, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    02/16/15
  6390. 12
    Macrocycles as factor XIa inhibitors
    Bristol-Myers Squibb
    02/16/15
  6391. 25
    Mandelamide heterocyclic compounds
    Bristol-Myers Squibb
    02/16/15
  6392. 54
    PIM kinase inhibitors and methods of their use
    Novartis
    02/16/15
  6393. 7
    Polysubstituted benzofurans and medicinal applications thereof
    Ikerchem
    02/16/15
  6394. 55
    Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors
    Pfizer
    02/16/15
  6395. 3
    Pyrazolylaminopyridine derivatives useful as kinase inhibitors
    Astrazeneca
    02/16/15
  6396. 6
    Substituted 2-amino-3-(sulfonyl)pyrazolo[1,5-a]pyrimidines - serotonin 5-HT6 receptor antagonists, method for use thereof
    TBA
    02/16/15
  6397. 11
    Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors
    Aska Pharmaceutical
    02/16/15
  6398. 28
    Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
    Leo Pharma
    02/16/15
  6399. 7
    6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines
    Boehringer Ingelheim International
    02/02/15
  6400. 111
    Aminopyrazole derivative
    Chugai Seiyaku Kabushiki Kaisha
    02/02/15
  6401. 40
    Azetidine derivatives
    Genentech
    02/02/15
  6402. 30
    Benzimidazole inhibitors of leukotriene production
    Boehringer Ingelheim International
    02/02/15
  6403. 10
    Fused cyclopentyl antagonists of CCR2
    Janssen Pharmaceutica
    02/02/15
  6404. 42
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer
    02/02/15
  6405. 154
    Indazole compounds useful as ketohexokinase inhibitors
    Janssen Pharmaceutica
    02/02/15
  6406. 100
    Pyrazoloquinoline compound
    Astellas Pharma
    02/02/15
  6407. 15
    Substituted 3-phenyl-1,2,4-Oxadiazole compounds
    Bristol-Myers Squibb
    02/02/15
  6408. 60
    Substituted oxazolidinones and their use in the field of blood coagulation
    Bayer Intellectual Property
    02/02/15
  6409. 14
    Tyrosine kinase inhibitors
    Chembridge
    02/02/15
  6410. 20
    1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds
    Hoffmann-La Roche
    01/26/15
  6411. 5
    1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
    The Regents Of The University Of Michigan
    01/26/15
  6412. 6
    Bivalent diazo bicyclic Smac mimetics and the uses thereof
    The Regents Of The University Of Michigan
    01/26/15
  6413. 17
    Carbamoyloxy arylalkan arylpiperazine analgesics
    Sk Biopharmaceuticals
    01/26/15
  6414. 94
    Carbazole and carboline kinase inhibitors
    Bristol-Myers Squibb
    01/26/15
  6415. 14
    Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives
    Centro Nacional De Investigaciones Oncologicas (Cnio
    01/26/15
  6416. 51
    Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors
    Novartis
    01/26/15
  6417. 20
    Substituted aminopropionic derivatives as neprilysin inhibitors
    Novartis
    01/26/15
  6418. 24
    Substituted imidazopyridinyl compounds
    Arqule
    01/26/15
  6419. 310
    Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases
    Novartis
    01/26/15
  6420. 112
    Tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
    Jeil Pharmaceutical
    01/26/15
  6421. 53
    2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations
    Wyeth
    01/19/15
  6422. 207
    Aminopyrimidine derivatives as LRRK2 modulators
    Genentech
    01/19/15
  6423. 94
    Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
    Theravance Respiratory
    01/19/15
  6424. 22
    Glycine compound
    Astellas Pharma
    01/19/15
  6425. 210
    Heterocyclic amine derivatives
    Hoffmann-La Roche
    01/19/15
  6426. 150
    Inhibitors of epoxide hydrolases for the treatment of inflammation
    The Regents Of The University Of California
    01/19/15
  6427. 42
    Pyrazole oxadiazole derivatives as S1P1 agonists
    Merck Serono
    01/19/15
  6428. 80
    Pyrazoloquinolines
    Merck Patent
    01/19/15
  6429. 9
    Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
    Richter Gedeon
    01/19/15
  6430. 48
    Pyrrolidine derivatives
    Genentech
    01/19/15
  6431. 16
    Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine
    Bayer Intellectual Property
    01/19/15
  6432. 155
    TRPV1 antagonists
    Abbvie
    01/19/15
  6433. 46
    2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors
    Merck Serono
    01/12/15
  6434. 17
    4-aminopyrimidine derivatives and their as as adenosine A2a receptor antagonists
    Palobiofarma
    01/12/15
  6435. 32
    Aminopyrimidine derivatives as LRRK2 modulators
    Genentech
    01/12/15
  6436. 24
    Apoptosis signal-regulating kinase 1 inhibitors
    Takeda Pharmaceutical
    01/12/15
  6437. 312
    Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases
    Astex Therapeutics
    01/12/15
  6438. 3
    Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
    Purdue Research Foundation
    01/12/15
  6439. 9
    Purine and deazapurine derivatives as pharmaceutical compounds
    The Institute Of Cancer Research
    01/12/15
  6440. 15
    Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
    Vanderbilt University
    01/12/15
  6441. 17
    Thiazole derivatives and use thereof
    Merck Serono
    01/12/15
  6442. 9
    Thiophene compounds for inflammation and immune-related uses
    Synta Pharmaceuticals
    01/12/15
  6443. 12
    Triazolones as fatty acid synthase inhibitors
    Glaxosmithkline
    01/12/15
  6444. 23
    4-substituted-2-amino-pyrimidine derivatives
    Abbvie
    12/22/14
  6445. 79
    Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors
    Merck Sharp & Dohme
    12/22/14
  6446. 46
    Aminopyrimidine derivatives as LRRK2 modulators
    Genentech
    12/22/14
  6447. 77
    Aryl benzylamine compounds
    Novartis
    12/22/14
  6448. 1
    Compound useful for the treatment of degenerative and inflammatory diseases
    Galapagos
    12/22/14
  6449. 74
    Inhibitors of histone deacetylase and prodrugs thereof
    Methylgene
    12/22/14
  6450. 38
    Pyridopyrazines as highly selective ras-Raf-Mek-Erk signal transduction pathway inhibitors
    Aeterna Zentaris
    12/22/14
  6451. 233
    Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array Biopharma
    12/22/14
  6452. 44
    TRPV1 antagonists
    TBA
    12/22/14
  6453. 18
    Tricyclic imidazole compounds as PDE10 inhibitors
    H. Lundbeck
    12/22/14
  6454. 20
    Alkoxy pyrimidine PDE10 inhibitors
    Merck Sharp & Dohme
    12/16/14
  6455. 97
    Heteroaryl substituted indole compounds useful as MMP-13 inhibitors
    Boehringer Ingelheim International
    12/16/14
  6456. 9
    Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof
    Shanghai Sun-Sail Pharmaceutical Science & Technology
    12/16/14
  6457. 152
    Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
    Pfizer
    12/16/14
  6458. 214
    Pyrazole compounds as CRTH2 antagonists
    Boehringer Ingelheim International
    12/16/14
  6459. 80
    Pyrimidine derivatives that inhibit FAK/PTK2
    Boehringer Ingelheim International
    12/16/14
  6460. 128
    Quinazoline compounds as kinase inhibitors
    Development Center For Biotechnology
    12/16/14
  6461. 30
    Substituted pyrrolotriazines as protein kinase inhibitors
    Bristol-Myers Squibb
    12/16/14
  6462. 15
    Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions
    Gruenenthal
    12/16/14
  6463. 5
    Dihydro-oxazolobenzodiazepinone compounds, a process for there preparation and pharmaceutical compositions containing them
    Les Laboratoires Servier
    12/15/14
  6464. 9
    Spiropiperidine prolylcarboxypeptidase inhibitors
    Merck Sharp & Dohme
    12/15/14
  6465. 8
    Targeting NAD biosynthesis in bacterial pathogens
    University Of Maryland, Baltimore
    12/15/14
  6466. 157
    Azabicyclo compound and salt thereof
    Taiho Pharmaceutical
    12/08/14
  6467. 33
    Benzimidazole inhibitors of leukotriene production
    Boehringer Ingelheim International
    12/08/14
  6468. 2
    Benzothiazoles having histamine H3 receptor activity
    High Point Pharmaceuticals
    12/08/14
  6469. 18
    Benzyl piperidine compound
    Dainippon Sumitomo Pharma
    12/08/14
  6470. 20
    CGRP receptor antagonists
    Merck Sharp & Dohme
    12/08/14
  6471. 350
    Heteroaryl compounds and their uses
    Novartis
    12/08/14
  6472. 64
    Imidazo-oxazine compound or salt thereof
    Taiho Pharmaceutical
    12/08/14
  6473. 16
    Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
    Aerpio Therapeutics
    12/08/14
  6474. 36
    Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors
    Almirall
    12/08/14
  6475. 20
    TGF-β signal transduction inhibitor
    Kyoto University
    12/08/14
  6476. 6
    Tetrahydropyrrolothiazine compounds
    Eli Lilly
    12/08/14
  6477. 70
    Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors
    Katholieke Universiteit Leuven
    12/08/14
  6478. 1
    5-lipoxygenase-activating protein inhibitor
    Panmira Pharmaceuticals
    11/24/14
  6479. 21
    Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands
    Gruenenthal
    11/24/14
  6480. 21
    Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof
    Amgen
    11/24/14
  6481. 7
    Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
    Bayer Intellectual Property
    11/24/14
  6482. 128
    Azaspirohexanones
    Boehringer Ingelheim International
    11/24/14
  6483. 9
    Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
    Galderma Research & Development
    11/24/14
  6484. 343
    Inhibitors of PI3 kinase and/or mTOR
    Amgen
    11/24/14
  6485. 17
    Inhibitors of glutaminyl cyclase
    Probiodrug
    11/24/14
  6486. 19
    Macrocyclic compounds and their use as kinase inhibitors
    Incyte
    11/24/14
  6487. 65
    PDE10 modulators
    Hoffmann-La Roche
    11/24/14
  6488. 84
    Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
    Allergan
    11/24/14
  6489. 292
    Substituted pyridinyl-pyrimidines and their use as medicaments
    Boehringer Ingelheim International
    11/24/14
  6490. 19
    3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides with selective PARP-1 inhibition
    Nerviano Medical Sciences
    11/18/14
  6491. 85
    3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
    Boehringer Ingelheim International
    11/18/14
  6492. 46
    Aminopyrimidines as SYK inhibitors
    Merck Sharp & Dohme
    11/18/14
  6493. 11
    Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof
    Bayer Intellectual Property
    11/18/14
  6494. 1
    Fused 2-aminothiazole compounds
    Dana-Farber Cancer Institute
    11/18/14
  6495. 162
    Heterocyclic compounds and their uses
    Amgen
    11/18/14
  6496. 19
    Heterocyclic kinase inhibitors
    Novartis
    11/18/14
  6497. 22
    Organic compounds
    Novartis
    11/18/14
  6498. 27
    Piperazine compound having a PGDS inhibitory effect
    Taiho Pharmaceutical
    11/18/14
  6499. 59
    Pyrazole compounds as CRTH2 antagonists
    Boehringer Ingelheim International
    11/18/14
  6500. 253
    Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
    Amgen
    11/18/14
  6501. 8
    Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
    Sapienza University Of Rome
    11/18/14
  6502. 52
    1,3-oxazines as BACE1 and/or BACE2 inhibitors
    Hoffmann-La Roche
    11/11/14
  6503. 26
    1,4-oxazepines as BACE1 and/or BACE2 inhibitors
    Hoffmann-La Roche
    11/11/14
  6504. 29
    4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use
    The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services
    11/11/14
  6505. 12
    HDAC inhibitors and therapeutic methods of using same
    University Of Illinois
    11/11/14
  6506. 32
    Heterocyclic compounds and their uses
    Amgen
    11/11/14
  6507. 8
    Macrocyclic inhibitors of hepatitis C virus
    Janssen Ireland
    11/11/14
  6508. 6
    Macrocyclic inhibitors of hepatitis C virus
    Medivir
    11/11/14
  6509. 5
    Metalloenzyme inhibitor compounds
    Viamet Pharmaceuticals
    11/11/14
  6510. 5
    Oxadiazole beta carboline derivatives as antidiabetic compounds
    Merck Sharp & Dohme
    11/11/14
  6511. 39
    Oxadiazole derivative having endothelial lipase inhibitory activity
    Shionogi
    11/11/14
  6512. 151
    Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
    Dermira (Canada
    11/11/14
  6513. 10
    Scriptaid isosteres and their use in therapy
    Karus Therapeutics
    11/11/14
  6514. 7
    Alkyl-substituted pyrazolopyrimidines
    Boehringer Ingelheim International
    11/05/14
  6515. 37
    Anti-infective agents against intracellular pathogens
    The Ohio State University Research Foundation
    11/05/14
  6516. 23
    Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors
    N30 Pharmaceuticals
    11/05/14
  6517. 79
    Disubstituted heteroaryl-fused pyridines
    Novartis
    11/05/14
  6518. 34
    Inhibitors of inv(16) leukemia
    University Of Virginia Patent Foundation
    11/05/14
  6519. 10
    Macrocyclic inhibitors of hepatitis C virus
    Janssen Ireland
    11/05/14
  6520. 19
    Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis
    Merck Serono
    11/05/14
  6521. 8
    Oxazole and thiazole compounds as KSP inhibitors
    Novartis
    11/05/14
  6522. 138
    Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists
    Janssen Pharmaceutica
    11/05/14
  6523. 37
    Pyrazolo pyrimidine derivatives
    Novartis
    11/05/14
  6524. 21
    Furanone derivative
    Sbi Biotech
    11/04/14
  6525. 169
    Spiroxazolidinone compounds
    Merck Sharp & Dohme
    11/04/14
  6526. 97
    4,5-dihydro-oxazol-2yl derivatives
    Hoffmann-La Roche
    10/28/14
  6527. 4
    7-azoniabicyclo[2.2.1]heptane derivatives, methods of production, and pharmaceutical uses thereof
    Theron Pharmaceuticals
    10/28/14
  6528. 422
    Aminopyrazoloquinazolines
    Boehringer Ingelheim International
    10/28/14
  6529. 5
    Aminopyridines useful as inhibitors of protein kinases
    Vertex Pharmaceuticals
    10/28/14
  6530. 35
    Co-crystals and salts of CCR3-inhibitors
    Boehringer Ingelheim International
    10/28/14
  6531. 722
    Compounds and compositions as Syk kinase inhibitors
    TBA
    10/28/14
  6532. 34
    Compounds as hypoxia mimetics, and compositions and uses thereof
    Betta Pharmaceuticals
    10/28/14
  6533. 25
    Inhibitors of PI3 kinase
    Amgen
    10/28/14
  6534. 50
    Inhibitors of bruton's tyrosine kinase
    Hoffmann-La Roche
    10/28/14
  6535. 5
    Protease inhibitors
    Medivir
    10/28/14
  6536. 43
    Protease inhibitors
    Taimed Biologies
    10/28/14
  6537. 62
    Pyrrolidine derivatives
    Hoffmann-La Roche
    10/28/14
  6538. 5
    7-deazapurine modulators of histone methyltransferase, and methods of use thereof
    Epizyme
    10/20/14
  6539. 77
    Benzodioxole piperazine compounds
    Hoffmann-La Roche
    10/20/14
  6540. 12
    Boron-containing small molecules
    Anacor Pharmaceuticals
    10/20/14
  6541. 31
    Compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
    Lg Life Sciences
    10/20/14
  6542. 2
    Inhibitors of C-FMS kinase
    Janssen Pharmaceutica
    10/20/14
  6543. 10
    Inhibitors of protein kinases
    Ingenium Pharmaceuticals
    10/20/14
  6544. 57
    Mineralocorticoid receptor antagonists
    Boehringer Ingelheim International
    10/20/14
  6545. 65
    N-hydroxy-benzamids for the treatment of cancer
    Hoffmann-La Roche
    10/20/14
  6546. 65
    Pharmaceutical compounds
    Sentinel Oncology
    10/20/14
  6547. 315
    Prokineticin receptor antagonists and uses thereof
    The Regents Of The University Of California
    10/20/14
  6548. 24
    Prolyl hydroxylase inhibitors and method of use
    Akebia Therapeutics
    10/20/14
  6549. 17
    SEC-hydroxycyclohexyl derivatives
    Hoffmann-La Roche
    10/20/14
  6550. 5
    Thieno[3,2-C]pyridine kinase inhibitors with improved CYP safety profile
    Abbvie
    10/20/14
  6551. 4
    2,5-disubstituted piperidine orexin receptor antagonists
    Merck Sharp & Dohme
    10/14/14
  6552. 9
    2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
    Shionogi
    10/14/14
  6553. 12
    Azaspirodecanone compounds
    Hoffmann-La Roche
    10/14/14
  6554. 10
    Compounds for treatment of Alzheimer's disease
    Purdue Research Foundation
    10/14/14
  6555. 9
    Galactoside inhibitors of galectins
    Galecto Biotech
    10/14/14
  6556. 17
    Imidazole derivatives used as TAFIa inhibitors
    Sanofi-Aventis Deutschland
    10/14/14
  6557. 329
    Nitrogen containing heteroaryl compounds
    Hoffmann-La Roche
    10/14/14
  6558. 15
    Organic compounds
    Novartis
    10/14/14
  6559. 12
    Preparation method of dihydroindene amide compounds, their pharmaceutical compositions containing compounds thereof and use as protein kinases inhibitor
    Harbin Gloria Pharmaceuticals
    10/14/14
  6560. 2
    Pyridazine carboxamide orexin receptor antagonists
    Merck Sharp & Dohme
    10/14/14
  6561. 95
    Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
    Genzyme
    10/14/14
  6562. 12
    Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
    University Of Utah Research Foundation
    10/14/14
  6563. 17
    Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
    Merck Sharp & Dohme
    10/14/14
  6564. 56
    3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators
    Actelion Pharmaceuticals
    10/06/14
  6565. 10
    8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
    Boehringer Ingelheim International
    10/06/14
  6566. 16
    Azabenzothiazole compounds, compositions and methods of use
    F. Hoffmann-La Roche
    10/06/14
  6567. 17
    Method of inhibiting C-KIT kinase
    Janssen Pharmaceutica
    10/06/14
  6568. 103
    Pseudodipeptides as MMP inhibitors
    Commissariat A L'Energie Atomique Et Aux Energies Alternatives
    10/06/14
  6569. 116
    Rho kinase inhibitors
    Boehringer Ingelheim International
    10/06/14
  6570. 42
    Serine/threonine kinase inhibitors
    Array Biopharma
    10/06/14
  6571. 11
    Triazole compounds II
    Roche Palo Alto
    10/06/14
  6572. 26
    Amino nicotinic and isonicotinic acid derivatives as DHODH inhibitors
    Amirall
    09/30/14
  6573. 9
    Amino tetrahydro-pyridopyrimidine PDE10 inhibitors
    Merck Sharp & Dohme
    09/30/14
  6574. 17
    Azetidine and piperidine compounds useful as PDE10 inhibitors
    Amgen
    09/30/14
  6575. 2
    Glucagon receptor antagonists, preparation and therapeutic uses
    Eli Lilly
    09/30/14
  6576. 5
    N-biarylamides
    Bayer Intellectual Property
    09/30/14
  6577. 13
    Piperidinyl naphthylacetic acids
    Hoffmann-La Roche
    09/30/14
  6578. 16
    Therapeutic agents
    Astrazeneca
    09/30/14
  6579. 4
    Treatment of liver disorders with PI3K inhibitors
    Gilead Calistoga
    09/30/14
  6580. 20
    Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
    Merck Sharp & Dohme
    09/30/14
  6581. 4
    Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    09/16/14
  6582. 173
    Fused heterocyclic compounds as orexin receptor modulators
    Janssen Pharmaceutica
    09/16/14
  6583. 2
    GSK-3 inhibitors
    Neuropharma
    09/16/14
  6584. 18
    Histone deacetylase inhibitors based simultaneously on trisubstituted 1H-pyrroles and aromatic and heteroaromatic spacers
    Universidad Del PaíS Vasco
    09/16/14
  6585. 31
    Indole derivative or pharmaceutically acceptable salt thereof
    Kissei Pharmaceutical
    09/16/14
  6586. 12
    Medical composition for treatment or prophylaxis of glaucoma
    Ube Industries
    09/16/14
  6587. 9
    Pharmaceutical composition
    Eisai R&D Management
    09/16/14
  6588. 9
    Quinolinone PDE2 inhibitors
    Merck Sharp & Dohme
    09/16/14
  6589. 48
    Spiro-oxindole MDM2 antagonists
    University Of Michigan
    09/16/14
  6590. 23
    Chemical compounds
    Astrazeneca
    09/08/14
  6591. 93
    Chromenone derivatives
    Astrazeneca
    09/08/14
  6592. 75
    Dihydrooxazol-2-amine derivatives
    Hoffmann-La Roche
    09/08/14
  6593. 5
    Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
    Pfizer
    09/08/14
  6594. 42
    Imidazo pyrazines
    Hoffmann-La Roche
    09/08/14
  6595. 14
    Prolylcarboxypeptidase inhibitors
    Merck Sharp & Dohme
    09/08/14
  6596. 29
    Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
    F. Hoffmann-La Roche
    09/08/14
  6597. 17
    Quinoline-carboxamide derivatives as P2Y12 antagonists
    Sanofi
    09/08/14
  6598. 41
    ALDH-2 inhibitors in the treatment of addiction
    Gilead Sciences
    09/03/14
  6599. 180
    Compounds
    Boehringer Ingelheim International
    09/03/14
  6600. 23
    Cyclohexane derivative having NPY Y5 receptor antagonism
    Shionogi
    09/03/14
  6601. 377
    Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Janssen Pharmaceutica
    09/03/14
  6602. 85
    Inhibitors of C-FMS kinase
    Janssen Pharmaceutica
    09/03/14
  6603. 20
    Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
    Bayer Intellectual Property
    09/03/14
  6604. 94
    Tetrahydro-pyrido-pyrimidine derivatives
    Novartis
    09/03/14
  6605. 35
    1H-pyrrolo[2,3 b]-pyridine derivatives
    Merck Patent
    08/26/14
  6606. 12
    Aminopyrimidines useful as inhibitors of protein kinases
    Vertex Pharmaceuticals
    08/26/14
  6607. 141
    Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications
    Mei Pharma
    08/26/14
  6608. 5
    Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals
    08/26/14
  6609. 46
    Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof
    Evotec
    08/26/14
  6610. 737
    Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors
    Boehringer Ingelheim International
    08/26/14
  6611. 6
    Pyridopyrimidine derivatives and use thereof
    The Asan Foundation
    08/26/14
  6612. 124
    Thiazolidinedione derivative and use thereof
    Industry-Academic Cooperation Foundation, Chosun University
    08/26/14
  6613. 31
    2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating pain
    Purde Pharma
    08/22/14
  6614. 574
    5-alkynyl-pyrimidines
    Boehringer Ingelheim International
    08/22/14
  6615. 692
    Amino azaheterocyclic carboxamides
    Merck Patent
    08/22/14
  6616. 351
    Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors
    Amgen
    08/22/14
  6617. 45
    Heterocyclic derivatives and their use in the treatment of neurological disorders
    Novartis
    08/22/14
  6618. 10
    Pyrazolopyrimidine JAK inhibitor compounds and methods
    Genentech
    08/22/14
  6619. 37
    Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
    Shionogi
    08/22/14
  6620. 4
    Use of PDE7 inhibitors for the treatment of movement disorders
    Omeros
    08/22/14
  6621. 173
    4-methylpyridopyrimidinone compounds
    Pfizer
    08/06/14
  6622. 24
    6-1H-imidazo-quinazoline and quinolines derivatives, new MAO inhibitors and imidazoline receptor ligands
    Rottapharm
    08/06/14
  6623. 60
    Aminodihydrothiazine derivatives
    Shionogi
    08/06/14
  6624. 111
    Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
    Albany Molecular Research
    08/06/14
  6625. 18
    Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
    Galderma Research & Development
    08/06/14
  6626. 14
    Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
    Merck Sharp & Dohme
    08/06/14
  6627. 163
    Inhibitors of beta-secretase
    Vitae Pharmaceuticals
    08/06/14
  6628. 5
    Piperidinyl derivative as a modulator of chemokine receptor activity
    Bristol-Myers Squibb
    08/06/14
  6629. 139
    Pyrrolo[2,3-D]pyrimidine compounds
    Pfizer
    08/06/14
  6630. 20
    Substituted imidazolones, compositions containing such compounds and methods of use
    Merck Sharp & Dohme
    08/05/14
  6631. 40
    Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
    Albany Molecular Research
    07/28/14
  6632. 150
    Azetidine derivatives, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International
    07/28/14
  6633. 12
    Disubstituted azepan orexin receptor antagonists
    Merck Sharp & Dohme
    07/28/14
  6634. 13
    Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases
    Bristol-Myers Squibb
    07/28/14
  6635. 13
    Pharmaceutical compositions comprising RET inhibitors and methods for the treatment of cancer
    Queen'S University At Kingston
    07/28/14
  6636. 93
    Selective androgen receptor modulators
    Radius Health
    07/28/14
  6637. 7
    Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof
    Tufts University
    07/28/14
  6638. 39
    Spiro-oxindole MDM2 antagonists
    University Of Michigan
    07/28/14
  6639. 5
    Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof
    TBA
    07/28/14
  6640. 7
    4-phenylamino-quinazolin-6-yl-amides
    Warner-Lambert
    07/22/14
  6641. 3
    Acylpiperazinones and their use as pharmaceuticals
    Fab Pharma
    07/22/14
  6642. 43
    Compounds for the treatment of CNS disorders
    Boehringer Ingelheim International
    07/22/14
  6643. 26
    Fused tricyclic dual inhibitors of CDK 4/6 and FLT3
    Amgen
    07/22/14
  6644. 119
    Inhibitors of JAK
    Hoffmann-La Roche
    07/22/14
  6645. 4
    Metalloenzyme inhibitor compounds
    Viamet Pharmaceuticals
    07/22/14
  6646. 64
    Pyridone and aza-pyridone compounds and methods of use
    Gilead Connecticut
    07/22/14
  6647. 427
    Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof
    Genentech
    07/22/14
  6648. 67
    Carboxy isatin hydrazones and their esters as Shp2 inhibitors
    H. Lee Moffitt Cancer Center And Research Institute
    07/21/14
  6649. 55
    Substituted 3-arylsulfonyl-pyrazolo[1,5-A]pyrimidines, serotonin 5-HT6 receptor antagonists and methods for the production and use thereof
    TBA
    07/09/14
  6650. 141
    5-alkynyl-pyrimidines
    Boehringer Ingelheim International
    07/08/14
  6651. 29
    Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity
    Neuraxon
    07/08/14
  6652. 9
    Certain compounds, compositions and methods
    Eisai
    07/08/14
  6653. 17
    Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
    Shionogi
    07/08/14
  6654. 4
    Inhibitors of bruton's tyrosine kinase
    Roche Palo Alto
    07/08/14
  6655. 16
    Modified macrophage migration inhibitory factor inhibitors
    The Feinstein Institute For Medical Research
    07/08/14
  6656. 7
    Substituted aniline derivatives
    Ucb Pharma
    07/08/14
  6657. 78
    Therapeutic agents
    Cancer Research Technology
    07/08/14
  6658. 272
    IRE-1α inhibitors
    Mannkind
    06/25/14
  6659. 146
    Compounds as tyrosine kinase modulators
    Allergan
    06/24/14
  6660. 17
    HSP90 inhibitors
    Takeda Pharmaceutical
    06/24/14
  6661. 197
    Peptidomimetic sulfamide compounds and antiviral uses thereof
    Novartis
    06/24/14
  6662. 215
    Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
    F. Hoffmann-La Roche
    06/24/14
  6663. 103
    Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks)
    Merck Serono
    06/24/14
  6664. 52
    Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
    Albany Molecular Research
    06/16/14
  6665. 67
    Nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof
    Japan Tobacco
    06/16/14
  6666. 35
    Pyrrolidine derivatives
    Hoffmann-La Roche
    06/16/14
  6667. 176
    Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
    Acetylon Pharmaceuticals
    06/16/14
  6668. 24
    Spirocyclic nitriles as protease inhibitors
    Sanofi
    06/16/14
  6669. 89
    Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer
    Human Biomolecular Research Institute
    06/16/14
  6670. 221
    2-aminooxazolines as TAAR1 ligands
    Hoffmann-La Roche
    06/04/14
  6671. 67
    2-morpholino-pyrido[3,2-D]pyrimidines
    Merck Serono
    06/04/14
  6672. 7
    C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof
    Shanghai Hengrui Pharmaceutical
    06/04/14
  6673. 29
    Cycloalkyl-substituted imidazole derivative
    Daiichi Sankyo
    06/04/14
  6674. 129
    Heteroarylcarboxylic acid ester derivative
    Ajinomoto
    06/04/14
  6675. 8
    Substituted dipyridyl-dihydropyrazolones and use thereof
    Bayer Intellectual Property
    06/04/14
  6676. 6
    Furopyridinyl-substituted 1,4-dihydropyridine derivatives and methods of use thereof
    Bayer Intellectual Property
    05/13/14
  6677. 102
    Thiazolyl mGluR5 antagonists and methods for their use
    Merck Sharp & Dohme
    05/13/14
  6678. 7
    Compositions for preventing and/or treating degenerative disorders of the central nervous system
    Amicus Therapeutics
    05/12/14
  6679. 665
    Heterocyclic inhibitors of glutaminase
    Calithera Biosciences
    05/12/14
  6680. 20
    Substituted imidazopyridinyl-aminopyridine compounds
    Arqule
    05/12/14
  6681. 78
    Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
    Selvita
    05/05/14
  6682. 2
    Glucagon receptor antagonists, preparation and therapeutic uses
    Eli Lilly
    05/05/14
  6683. 11
    Methods and compositions for sleep disorders and other disorders
    Intra-Cellular Therapies
    05/05/14
  6684. 6
    Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
    Inotek Pharmaceuticals
    05/05/14
  6685. 69
    Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
    Sanofi
    05/05/14
  6686. 89
    5-alkynyl-pyridines
    Boehringer Ingelheim International
    04/28/14
  6687. 24
    Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders
    Vitae Pharmaceuticals
    04/28/14
  6688. 5
    Protein kinase inhibitors
    Tiger Pharmatech
    04/28/14
  6689. 2
    Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
    Nerviano Medical Sciences
    04/28/14
  6690. 23
    Trypsin-like serine protease inhibitors, and their preparation and use
    The Medicines Company (Leipzig
    04/28/14
  6691. 165
    Cytoskeletal active rho kinase inhibitor compounds, composition and use
    Inspire Pharmaceuticals
    04/18/14
  6692. 84
    Imidazo[5,1-f][1,2,4]triazines for the treatment of neurological disorders
    Pfizer
    04/18/14
  6693. 20
    Imidazole derivatives and their use as modulators of cyclin dependent kinases
    Astex Therapeutics
    04/18/14
  6694. 29
    KAT II inhibitors
    Pfizer
    04/18/14
  6695. 24
    Prolyl hydroxylase inhibitors and methods of use
    Akebia Therapeutics
    04/18/14
  6696. 8
    Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
    Merck Sharpe & Dohme
    04/14/14
  6697. 60
    Aryl-benzocycloalkyl amide derivatives
    Hoffmann-La Roche
    04/14/14
  6698. 79
    Benzodioxole piperidine compounds
    Hoffmann-La Roche
    04/14/14
  6699. 61
    Compounds and compositions as protein kinase inhibitors
    TBA
    04/14/14
  6700. 34
    Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
    Vitae Pharmaceuticals
    04/14/14
  6701. 109
    Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
    Vitae Pharmaceuticals
    04/14/14
  6702. 145
    Fused ring compound and use thereof
    Takeda Pharmaceutical
    04/14/14
  6703. 5
    Imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines as mark inhibitors
    Merck Sharp & Dohme
    04/14/14
  6704. 3
    Inhibitors of PDE10
    Bristol-Myers Squibb
    04/14/14
  6705. 9
    Metastin derivative and use thereof
    Kyoto University
    04/14/14
  6706. 36
    Selective kinase inhibitors
    Reaction Biology
    04/14/14
  6707. 77
    Substituted heteroarylamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
    Vanderbilt University
    04/14/14
  6708. 14
    Bacterial thioredoxin reductase inhibitors and methods for use thereof
    Thioredoxin Systems
    03/17/14
  6709. 5
    Isonicotinamide orexin receptor antagonists
    Merck Sharp & Dohme
    03/17/14
  6710. 139
    Kinase inhibitors and methods of their use
    Novartis
    03/17/14
  6711. 12
    Nitrogen-containing heterocyclic compound and use of same
    Takeda Pharmaceutical
    03/17/14
  6712. 45
    Pyrrolotriazine kinase inhibitors
    Bristol-Myers Squibb
    03/17/14
  6713. 16
    Trisubstituted purine derivatives
    Cyclacel
    03/17/14
  6714. 8
    2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors
    Korea Institute Of Science And Technology
    03/12/14
  6715. 103
    Aminomethyl-4-imidazoles
    Hoffmann-La Roche
    03/12/14
  6716. 141
    Anellated pyridine compounds
    Hoffmann-La Roche
    03/12/14
  6717. 15
    Heterocyclic compound
    Takeda Pharmaceutical
    03/12/14
  6718. 14
    Heterocyclic compounds and uses thereof
    Celgene Avilomics Research
    03/12/14
  6719. 53
    Substituted indole compounds having NOS inhibitory activity
    Neuraxon
    03/12/14
  6720. 9
    1,4-diaryl-pyrimidopyridazine-2,5-diones and their use
    Bayer Intellectual Property
    03/06/14
  6721. 5
    6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta
    Icos
    03/06/14
  6722. 253
    Chemical compounds
    Boehringer Ingelheim International
    03/06/14
  6723. 7
    Opioid antagonists
    Adolor
    03/06/14
  6724. 750
    Pyrolinone derivative and pharmaceutical composition comprising the same
    Shionogi
    03/06/14
  6725. 9
    Substituted dihydropyrazolones and their use
    Bayer Intellectual Property
    03/06/14
  6726. 12
    Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
    Merck Sharp & Dohme
    03/06/14
  6727. 31
    5-substituted-2-phenylamino benzamides as MEK inhibitors
    Chugai Seiyaku Kabushiki Kaisha
    02/24/14
  6728. 5
    Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
    Research Triangle Institute
    02/24/14
  6729. 10
    Bicyclic dihydroimidazolone CGRP receptor antagonists
    Merck Sharp & Dohme
    02/24/14
  6730. 119
    Compounds and their administration for treating a neurodegenerative disease as well as a method for identifying a compound capable of inhibiting a kinase, such as LRRK
    Medical Research Council Technology
    02/24/14
  6731. 4
    Derivatives of azaindoles as inhibitors of protein kinases ABL and SRC
    Oribase Pharma
    02/24/14
  6732. 152
    Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
    Albany Molecular Research
    02/24/14
  6733. 11
    JNK modulators
    Hoffmann-La Roche
    02/24/14
  6734. 47
    Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors
    The Medicines Company (Leipzig
    02/24/14
  6735. 66
    Modulators of serotonin receptor
    Janssen Pharmaceutica
    02/24/14
  6736. 173
    Oxadiazole inhibitors of leukotriene production
    Boehringer Ingelheim International
    02/24/14
  6737. 10
    Prolylcarboxypeptidase inhibitors
    Merck Sharp & Dohme
    02/24/14
  6738. 24
    Pyridyl piperidine orexin receptor antagonists
    Merch Sharp & Dohme
    02/24/14
  6739. 64
    Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
    Boehringer Ingelheim International
    02/24/14
  6740. 5
    Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
    Icos
    02/24/14
  6741. 22
    SGLT-2 inhibitors, methods of making them, and uses thereof
    Albany Molecular Research
    02/24/14
  6742. 87
    Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
    Vanderbilt University
    02/24/14
  6743. 10
    Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD
    Bayer Intellectual Property
    02/24/14
  6744. 116
    Triazolopyridine compounds as PIM kinase inhibitors
    Array Biopharma
    02/24/14
  6745. 10
    Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
    Merck Sharp & Dohme
    01/21/14
  6746. 7
    Tetrahydro-pyrazolo[1,5-a]pyrido-pyrimidines as antagonists of serotonin 5-HT6 receptors, methods for the production and use thereof
    TBA
    01/21/14
  6747. 3
    Methods of using 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine compounds
    Proximagen
    01/20/14
  6748. 6
    Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
    Bristol-Myers Squibb
    01/20/14
  6749. 21
    Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase
    University Of Utah Research Foundation
    01/20/14
  6750. 11
    Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
    Molecular Insight Pharmaceuticals
    01/20/14
  6751. 97
    Benzimidazole derivatives: preparation and pharmaceutical applications
    Mei Pharma
    01/14/14
  6752. 11
    Compound useful for the treatment of degenerative and inflammatory diseases
    Galapagos
    01/14/14
  6753. 103
    Compounds and compositions as protein kinase inhibitors
    Novartis
    01/14/14
  6754. 93
    Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
    Theravance
    01/14/14
  6755. 2
    Imidazolothiazole compounds and methods of use thereof
    Ambit Biosciences
    01/14/14
  6756. 16
    S1P3 receptor inhibitors for treating pain
    Allergan
    01/14/14
  6757. 13
    (EN) 3-sulfonyl-pyrazolo[1,5-a] pyrimidines / antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
    Avincuro Pharmaceuticals
    01/03/14
  6758. 4
    2-amino-3-sulphonyl-tetrahydro-pyrazolo[1,5-A]pyrido-pyrimidine antagonists of serotonin 5-HT6 receptors, methods for the production and use thereof
    TBA
    01/03/14
  6759. 27
    Chemical compounds
    Astrazeneca
    01/03/14
  6760. 23
    Compounds and compositions as kinase inhibitors
    Irm
    01/03/14
  6761. 5
    Non-amidic linkers with branched termini as CGRP receptor antagonists
    Merck Sharp & Dohme
    01/03/14
  6762. 8
    Substituted 4-(indazolyl)-1,4-dihydropyridines and methods of use thereof
    Bayer Intellectual Property
    01/03/14
  6763. 60
    Aminodihydrothiazine derivatives
    Shionogi
    12/22/13
  6764. 21
    Furo[3, 2-B] pyrrol-3-ones as cathespin S inhibitors
    Amura Therapeutics
    12/22/13
  6765. 2
    Inhibitors of CXCR2
    Sanofi
    12/22/13
  6766. 8
    Phytoestrogenic formulations for alleviation or prevention of neurodegenerative diseases
    University Of Southern California
    12/22/13
  6767. 21
    Tricyclic compound and pharmaceutical use thereof
    Takeda Pharmaceutical
    12/22/13
  6768. 17
    17Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-related diseases
    Universitaet Des Saarlandes
    12/09/13
  6769. 14
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme
    12/09/13
  6770. 24
    Substituted indanes, method for the production thereof, and use thereof as drugs
    Sanofi
    12/09/13
  6771. 14
    Triazole compounds as KSP inhibitors
    Novartis
    12/09/13
  6772. 38
    Viral polymerase inhibitors
    Biota Scientific Management
    12/09/13
  6773. 97
    C-aryl glucoside SGLT2 inhibitors and pharmaceutical compositions comprising same
    Green Cross
    12/03/13
  6774. 10
    Estrogen receptor ligands and methods of use thereof
    Gtx
    12/03/13
  6775. 4
    Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use
    St George'S Hosptial Medical School
    12/03/13
  6776. 230
    Substituted benzo-pyrido-triazolo-diazepine compounds
    Arqule
    12/03/13
  6777. 9
    Triazole derivatives with improved receptor activity and bioavailability properties as ghrelin antagonists of growth hormone secretagogue receptors
    Aeterna Zentaris
    12/03/13
  6778. 6
    3-substituted-2-(arlyalkyl)-1-azabicycloalkanes and methods of use thereof
    Targacept
    11/26/13
  6779. 48
    Aminodihydrothiazine derivatives substituted with a cyclic group
    Shionogi
    11/26/13
  6780. 289
    Compounds for the treatment of inflammatory disorders
    Merck Sharp & Dohme
    11/26/13
  6781. 10
    Inhibitors
    Probiodrug
    11/26/13
  6782. 43
    Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
    Merck Sharp & Dohme
    11/26/13
  6783. 55
    Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
    Almirall
    11/18/13
  6784. 8
    Compounds having CRTH2 antagonist activity
    Atopix Therapeutics
    11/18/13
  6785. 4
    Inhibitors of Burton's tyrosine kinase
    Roche Palo Alto
    11/18/13
  6786. 66
    Inhibitors of JNK
    Roche Palo Alto
    11/18/13
  6787. 50
    Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors
    Novartis
    11/18/13
  6788. 10
    Tetrahydroquinoxaline urea derivatives as modulators of 11-B-hydroxysteroid dehydrogenase type I
    Sanofi
    11/18/13
  6789. 31
    6,7-unsaturated-7-carbamoyl substituted morphinan derivative
    Shionogi
    11/11/13
  6790. 19
    Compounds for inhibiting semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) and uses thereof for treatment and prevention of diseases
    Semmelweis Egyetem
    11/11/13
  6791. 8
    Inhibitors of AKT activity
    Merck Sharp & Dohme
    11/11/13
  6792. 23
    Piperidine derivatives as modulators of chemokine receptor activity
    Bristol-Myers Squibb
    11/11/13
  6793. 16
    Prolyl hydroxylase inhibitors
    Aerpio Therapeutics
    11/11/13
  6794. 199
    Azetidine derivatives
    Boehringer Ingelheim International
    11/04/13
  6795. 155
    Diaza-spiro[5.5]undecanes
    Novartis
    11/04/13
  6796. 10
    Modulators of protein kinase signaling
    Novotyr Therapeutics
    11/04/13
  6797. 82
    Pyrazolothiazole compound
    Eisai R&D Management
    11/04/13
  6798. 141
    Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
    Taiho Pharmaceutical
    11/04/13
  6799. 31
    Buprenophine analogs
    Purdue Pharma
    10/25/13
  6800. 5
    Inhibitors
    Probiodrug
    10/25/13
  6801. 26
    Macrocyclic indoles as hepatitis C virus inhibitors
    Janssen Ireland
    10/25/13
  6802. 83
    Pyrrolidine derivatives
    Hoffmann-La Roche
    10/25/13
  6803. 82
    Pyrrolopyrazoles, potent kinase inhibitors
    Agouron Pharmaceuticals
    10/25/13
  6804. 11
    Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
    Bayer Intellectual Property
    10/25/13
  6805. 10
    3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
    Merck Sharp & Dohme
    10/18/13
  6806. 154
    6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
    Allergan
    10/18/13
  6807. 48
    Aminodihydrothiazine derivatives substituted with a cyclic group
    Shionogi
    10/18/13
  6808. 59
    Oxidase inhibitors and their use
    Oryzon Genomics
    10/18/13
  6809. 21
    Substituted tricyclic compounds and methods of use thereof
    Bayer Intellectual Property
    10/18/13
  6810. 60
    Sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents
    Bayer Intellectual Property
    10/18/13
  6811. 50
    Tetrahydro-pyran derivatives
    Hoffmann-La Roche
    10/18/13
  6812. 17
    7-membered ring compound and method of production and pharmaceutical application thereof
    Daiichi Sankyo
    10/07/13
  6813. 210
    Aminomethyl quinolone compounds
    Hoffmann-La Roche
    10/07/13
  6814. 7
    Compounds for the treatment of hepatitis C
    Bristol-Myers Squibb
    10/07/13
  6815. 74
    Glucagon receptor modulators
    Pfizer
    10/07/13
  6816. 88
    Heterocyclic oxime compounds
    Novartis
    10/07/13
  6817. 25
    Methyl-pyrrolidine ether derivatives
    Hoffmann-La Roche
    10/07/13
  6818. 31
    Azaquinazolinediones chymase inhibitors
    Boehringer Ingelheim International
    09/30/13
  6819. 6
    CXCR2 inhibitors
    Sanofi
    09/30/13
  6820. 76
    Conformationally restricted urea inhibitors of soluble epoxide hydrolase
    The Regents Of The University Of California
    09/30/13
  6821. 4
    Inhibitors of protein kinases
    Portola Pharmaceuticals
    09/30/13
  6822. 22
    Piperazine compounds
    Amura Therapeutics
    09/30/13
  6823. 34
    5-HT3 receptor modulators, methods of making, and use thereof
    Albany Molecular Research
    09/16/13
  6824. 20
    HIV protease inhibitors and methods for using
    Purdue Research Foundation
    09/16/13
  6825. 52
    Heterocyclic compound and use thereof
    Takeda Pharmaceutical
    09/16/13
  6826. 18
    Imidazopyridines and imidazopyrimidines as HIV-1 reverse transcriptase inhibitors
    Csir, Pretoria (Za
    09/16/13
  6827. 6
    P53 activating compounds
    University Court Of The University Of Dundee
    09/16/13
  6828. 365
    Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
    Cephalon
    09/16/13
  6829. 176
    Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
    Vitae Pharmaceuticals
    09/10/13
  6830. 6
    Heterocyclic compound and use thereof
    Takeda Pharmaceutical
    09/10/13
  6831. 80
    Heterocyclic hydrazone compounds
    Novartis
    09/10/13
  6832. 36
    Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
    Hoffmann-La Roche
    09/10/13
  6833. 18
    Adenosine compounds and their use thereof
    Inotek Pharmaceuticals
    09/09/13
  6834. 320
    Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors
    Amgen
    09/09/13
  6835. 111
    Beta-lactamase inhibitors
    Merck Sharp & Dohme
    09/03/13
  6836. 6
    Bryostatin analogues, synthetic methods and uses
    The Board Of Trustees Of The Leland Stanford Junior University
    09/03/13
  6837. 40
    Hexahydropyrroloimidazolone compounds
    Hoffmann-La Roche
    09/03/13
  6838. 9
    Inhibitors of Bruton's tyrosine kinase
    Pharmacyclics
    09/03/13
  6839. 27
    Inhibitors of c-fms kinase
    Janssen Pharmaceutica
    09/03/13
  6840. 8
    Macrocyclic integrase inhibitors
    Elanco Animal Health Ireland
    09/03/13
  6841. 17
    Organic compounds
    Novartis
    09/03/13
  6842. 14
    Derivatives of 7-alkynyl-1,8-Naphthyridones, Preparation Method Therefore and Use of Same in Therapeutics
    Sanofi
    08/29/13
  6843. 29
    Urokinase inhibitors, production and use thereof
    The Medicines
    08/29/13
  6844. 15
    (3-aryl-piperazin-1-yl), (2-aryl-morpholin-4-yl) and (2-aryl-thiomorpholin-4-yl) derivatives of 6,7-dialkoxy-quinazoline, 6,7-dialkoxyphtalazine and 6,7-dialkoxyisoquinoline as PDE10A enzyme inhibitors
    H. Lundbeck
    08/28/13
  6845. 9
    2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease
    Merck Sharp & Dohme
    08/28/13
  6846. 17
    Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors
    Merck Sharp & Dohme
    08/28/13
  6847. 4
    Benzimidazole derivatives and their use for modulating the GABAA receptor complex
    Aniona
    08/28/13
  6848. 1
    Chromane derivatives as TRPV3 modulators
    Glenmark Pharamceuticals
    08/28/13
  6849. 11
    Salvinorin derivatives and uses thereof
    The Mclean Hospital
    08/28/13
  6850. 184
    Inhibitors
    Probiodrug
    08/19/13
  6851. 1
    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
    Vertex Pharmaceuticals
    08/19/13
  6852. 346
    Substituted imidazopyr- and imidazotri-azines
    Osi Pharmaceuticals
    08/19/13
  6853. 4
    Substituted oxazolidinones and their use
    Bayer Intellectual Property
    08/19/13
  6854. 10
    Translocator protein ligands
    The University Of Sydney
    08/19/13
  6855. 22
    9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer
    Astrazeneca
    08/12/13
  6856. 262
    Benzotriazine inhibitors of kinases
    Targegen
    08/12/13
  6857. 5
    Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors
    Incyte
    08/12/13
  6858. 4
    Phenylpropionamide compounds and the use thereof
    Purdue Pharma
    08/12/13
  6859. 6
    Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors
    Centre National De La Recherche Scientifique
    08/12/13
  6860. 10
    Thienopyrimidines for pharmaceutical compositions
    Boehringer Ingelheim International
    08/12/13
  6861. 66
    Antiviral compounds
    Gilead Sciences
    08/05/13
  6862. 3
    Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
    Merck Patent
    08/05/13
  6863. 8
    Imidazo-, pyrazolopyrazines and imidazotriazines and their use
    Bayer Intellectual Property
    08/05/13
  6864. 14
    Inhibitors of c-fms kinase
    Janssen Pharmaceutica
    08/05/13
  6865. 7
    Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators
    Purdue Pharma
    08/05/13
  6866. 6
    Bridged bicyclic RHO kinase inhibitor compounds, composition and use
    Inspire
    07/29/13
  6867. 30
    Histone deacetylase inhibitors
    Orchid Chemicals & Pharmaceuticals
    07/29/13
  6868. 12
    Inhibitors of Bruton's tyrosine kinase
    Pharmacyclics
    07/29/13
  6869. 14
    Azacyclic compounds
    Hoffmann-La Roche
    07/24/13
  6870. 6
    Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer
    The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
    07/24/13
  6871. 22
    Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent
    Lg Life Sciences
    07/24/13
  6872. 33
    Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
    Sanofi
    07/24/13
  6873. 44
    MAPK/ERK kinase inhibitors
    Takeda Pharmaceutical
    07/24/13
  6874. 1
    Pyrimidinecarboxamide derivatives as inhibitors of Syk kinase
    Glaxo Group
    07/24/13
  6875. 17
    Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting PARP
    Eisai
    07/08/13
  6876. 10
    Method of reducing intraocular pressure in humans
    Inotek Pharmaceuticals
    07/08/13
  6877. 63
    Nitrogen-containing heteroaryl derivatives
    Hoffman-La Roche
    07/08/13
  6878. 20
    Nitrogen-containing heterocyclic compound and use thereof
    Takeda Pharmaceutical
    07/08/13
  6879. 38
    2-pyridyloxy-4-nitrile orexin receptor antagonists
    TBA
    06/25/13
  6880. 1
    Compounds useful as inhibitors of atr kinase
    Vertex Pharmaceuticals
    06/24/13
* for human-derived proteins