Patent: (prefix with "US" like US6078908)
  1. Patent
    Data
    Compounds
    HGNC
    (for human-derived proteins)
    Patent Title
    Organization
    Deposition
    Downloads
  2. 229
    COMPOUNDS
    Enterprise Therapeutics Ltd
    01/13/22
  3. 179
    Inhibitors of cysteine proteases and methods of use thereof
    Pardes Biosciences, Inc.
    01/13/22
  4. 117
    Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    PHARMAKEA, INC.
    01/09/22
  5. 29
    1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
    Addex Pharmaceuticals S.A.; Janssen Pharmaceuticals, Inc.
    01/07/22
  6. 21
    Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
    BAYER PHARMA AKTIENGESELLSCHAFT
    01/07/22
  7. 101
    Bicyclic amide compounds and methods of use thereof
    Genentech, Inc.
    01/07/22
  8. 223
    Bicyclic sulfones and sulfoxides and methods of use thereof
    Genentech, Inc.
    01/07/22
  9. 215
    Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    01/07/22
  10. 41
    Inhibitors of RIP1 kinase and methods of use thereof
    Genentech, Inc.
    01/07/22
  11. 13
    Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
    Celon Pharma S.A.
    01/07/22
  12. 31
    Small molecule inhibitors of Galectin-3
    Bristol-Myers Squibb Company
    01/07/22
  13. 201
    Substituted 6-azabenzimidazole compounds
    Gilead Sciences, Inc.
    01/07/22
  14. 275
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    01/07/22
  15. 146
    2,2-difluorodioxolo A2A receptor antagonists
    Merck Sharp & Dohme Corp.
    12/28/21
  16. 19
    Androgen receptor modulating compounds
    ORION CORPORATION
    12/28/21
  17. 26
    Galactoside inhibitor of galectins
    GALECTO BIOTECH AB
    12/28/21
  18. 175
    Glycosidase inhibitors
    Asceneuron SA
    12/28/21
  19. 198
    Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
    SK BIOPHARMACEUTICALS CO., LTD.
    12/28/21
  20. 48
    Sulfonamide compounds
    Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute
    12/28/21
  21. 45
    2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
    DOMPÉ FARMACEUTICI S.P.A.
    12/27/21
  22. 729
    2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    IDEAYA BIOSCIENCES, INC.
    12/27/21
  23. 5
    Alkylphenyl compounds
    Bristol-Myers Squibb Company
    12/27/21
  24. 127
    Aminopyrazine derivatives as PI3K-γ inhibitors
    Incyte Corporation
    12/27/21
  25. 26
    Azetidine derivative, preparation method therefor, and use thereof
    SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    12/27/21
  26. 148
    Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
    Board of Regents, The University of Texas System
    12/27/21
  27. 12
    Dihydropyrimidinyl benzazepine carboxamide compounds
    Hoffmann-La Roche Inc.
    12/27/21
  28. 39
    Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof
    Beijing Innocare Pharma Tech Co., Ltd
    12/27/21
  29. 198
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    12/27/21
  30. 436
    Heteroaryl-substituted triazoles as APJ receptor agonists
    AMGEN INC.
    12/27/21
  31. 36
    Hydroxamic acids comprising pyrazole moiety and uses thereof
    HAWAII BIOTECH, INC.
    12/27/21
  32. 70
    Indolinones compounds and their use in the treatment of fibrotic diseases
    RespiVert Limited
    12/27/21
  33. 202
    Inhibitor compounds
    Cancer Research Technology Limited
    12/27/21
  34. 35
    Piperazine substituted azapine derivatives and uses thereof
    ALAIRION, INC.
    12/27/21
  35. 27
    Piperazinyl norbenzomorphan compounds and methods for using the same
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    12/27/21
  36. 41
    Piperidines as covalent menin inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    12/27/21
  37. 208
    Piperidinyl-3-(aryloxy)propanamides and propanoates
    Takeda Pharmaceutical Company Limited
    12/27/21
  38. 159
    Selective estrogen receptor down-regulators
    AstraZeneca AB
    12/27/21
  39. 8
    Substituted isoquionline derivatives as immunomudulators
    Bristol-Myers Squibb Company
    12/27/21
  40. 33
    Substituted piperidines for the treatment of cancer
    LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD
    12/27/21
  41. 1145
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    12/27/21
  42. 30
    Thiadiazole IRAK4 compounds
    Gilead Sciences, Inc.
    12/27/21
  43. 271
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics Limited
    12/23/21
  44. 964
    Cot modulators and methods of use thereof
    Gilead Sciences, Inc.
    12/23/21
  45. 57
    Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
    GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    12/20/21
  46. 211
    Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    12/20/21
  47. 6
    Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
    Incyte Corporation
    12/20/21
  48. 15
    Small molecule inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    12/20/21
  49. 478
    3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
    MERCK SHARP & DOHME CORP.
    12/19/21
  50. 329
    Arylquinazolines
    MERCK PATENT GMBH
    12/19/21
  51. 55
    Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
    ARVINAS OPERATIONS, INC.
    12/19/21
  52. 26
    Diacylglycerol acyl transferase 2 inhibitor
    Pfizer Inc.
    12/19/21
  53. 102
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    12/19/21
  54. 13
    Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
    DANA-FARBER CANCER INSTITUTE, INC.
    12/19/21
  55. 987
    Benzimidazole-proline derivatives
    IDORSIA PHARMACEUTICALS LTD
    12/14/21
  56. 135
    Metalloenzyme inhibitor compounds
    PHASEBIO PHARMACEUTICALS, INC.
    12/14/21
  57. 10
    Methods of identifying SENP1 inhibitors
    CITY OF HOPE
    12/14/21
  58. 17
    Pyridine derivative as ASK1 inhibitor and preparation method and use thereof
    TBA
    12/14/21
  59. 11
    Quinazoline compound for EGFR inhibition
    MEDSHINE DISCOVERY INC.
    12/14/21
  60. 32
    Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
    Principia Biopharma Inc.
    12/14/21
  61. 4
    Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
    Blueprint Medicines Corporation
    12/14/21
  62. 11
    TYK2 inhibitors, uses, and methods for production thereof
    Nimbus Lakshmi, Inc.
    12/14/21
  63. 42
    VMAT2 inhibitor compounds and compositions thereof
    Neurocrine Biosciences, Inc.
    12/14/21
  64. 146
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences, Inc.
    12/06/21
  65. 11
    Farnesoid X receptor modulators
    Intercept Pharmaceuticals, Inc.
    12/06/21
  66. 5
    Methods to determine KDM1A target engagement and chemoprobes useful therefor
    Oryzon Genomics S.A.
    12/06/21
  67. 99
    Apoptosis signal-regulating kinase inhibitors and uses thereof
    SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
    12/05/21
  68. 100
    Carboxamide-pyrimidine derivatives as SHP2 antagonists
    Merck Patent GmbH
    12/05/21
  69. 551
    Compounds of formulas (VII), (VIII), (IX), (XI), (XII), (XIII), and (XIV) as muscarinic receptor 4(M4) antagonists for treating neurological diseases
    Neurocrine Biosciences, Inc.
    12/05/21
  70. 16
    Diacylglycerol acyl transferase 2 inhibitors
    Pfizer Inc.
    12/05/21
  71. 17
    Ethynyl derivatives
    Hoffmann-La Roche Inc.
    12/05/21
  72. 52
    Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
    Nikang Therapeutics, Inc.
    12/05/21
  73. 390
    Naphthyridines as inhibitors of HPK1
    Genentech, Inc.
    12/05/21
  74. 53
    Poly-ADP ribose polymerase (PARP) inhibitors
    Mitobridge, Inc.
    12/05/21
  75. 94
    Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    12/05/21
  76. 65
    Pyridinyl pyrazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    12/05/21
  77. 366
    Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders
    THE SCRIPPS RESEARCH INSTITUTE
    12/05/21
  78. 67
    Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
    Merck Sharp & Dohme Corp.
    12/05/21
  79. 825
    Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    12/05/21
  80. 35
    1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
    Merck Patent GmbH
    11/29/21
  81. 166
    1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    11/29/21
  82. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    11/29/21
  83. 3
    3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY LTD
    11/29/21
  84. 205
    4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
    ARRAY BIOPHARMA INC.; CELGENE CORPORATION
    11/29/21
  85. 35
    Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
    Bristol-Myers Squibb Company
    11/29/21
  86. 6
    Cyclic dinucleotides as sting agonists
    Janssen Biotech, Inc.
    11/29/21
  87. 145
    Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
    Board of Regents, The University of Texas System
    11/29/21
  88. 134
    Heteroaryl inhibitors of PAD4
    Padlock Therapeutics, Inc.
    11/29/21
  89. 7
    Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
    Oblique Therapeutics AB
    11/29/21
  90. 12
    Heterocyclic compounds as adenosine antagonists
    NUVATION BIO INC.
    11/29/21
  91. 23
    Indolizine derivatives and their application in medicine
    KIND PHARMACEUTICAL
    11/29/21
  92. 97
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    11/29/21
  93. 131
    Phosphatidylinositol 3-kinase inhibitors
    Gilead Sciences, Inc.
    11/29/21
  94. 34
    Piperidinyl-propanone derivatives
    Merck Patent GmbH
    11/29/21
  95. 18
    Second generation GRP94-selective inhibitors
    University of Kansas
    11/29/21
  96. 36
    Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
    Merck Sharp & Dohme Corp.
    11/29/21
  97. 812
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
    Nimbus Saturn, Inc.
    11/29/21
  98. 823
    Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists
    Nimbus Saturn, Inc.
    11/29/21
  99. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme Corp.
    11/29/21
  100. 36
    Substituted pyrimidines as LRKK2 inhibitors
    DENALI THERAPEUTICS INC.
    11/29/21
  101. 7
    Tetrahydroquinoline-based bromodomain inhibitors
    St. Jude Children''s Research Hospital
    11/29/21
  102. 90
    Therapeutic compounds and methods of use thereof
    Genentech, Inc.
    11/29/21
  103. 145
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    11/29/21
  104. 207
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    11/29/21
  105. 76
    Tricyclic heterocyclic derivatives and uses thereof
    AUCKLAND UNISERVICES LIMITED
    11/29/21
  106. 42
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.
    11/29/21
  107. 491
    [1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient
    Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology
    11/29/21
  108. 299
    Amino-pyrrolopyrimidinone compounds and methods of use thereof
    ArQule, Inc.
    11/28/21
  109. 169
    Biaryloxy derivatives as TTX-S blockers
    RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.
    11/28/21
  110. 150
    Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
    WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    11/28/21
  111. 44
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    11/28/21
  112. 115
    Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
    AMGEN INC.
    11/28/21
  113. 396
    Therapeutic compounds
    CELGENE QUANTICEL RESEARCH, INC.
    11/28/21
  114. 27
    Type of aryl benzofuran amidated derivative and medical use thereof
    CHINA PHARMACEUTICAL UNIVERSITY
    11/28/21
  115. 36
    2,6-disubstituted pyridine derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    11/22/21
  116. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    11/22/21
  117. 569
    CDK2 inhibitors
    Pfizer Inc.
    11/22/21
  118. 68
    Cyanopyrrolidine derivatives with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    11/22/21
  119. 35
    Factor XIIa inhibitors
    Merck Sharp & Dohme Corp.
    11/22/21
  120. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    11/22/21
  121. 72
    Heteroaromatic compounds and their use as dopamine D1 ligands
    Pfizer Inc.
    11/22/21
  122. 9
    LSD1 inhibitors and medical uses thereof
    Constellation Pharmaceuticals, Inc.
    11/22/21
  123. 126
    Pyrazolopyrimidine compounds and uses thereof
    Incyte Corporation
    11/22/21
  124. 800
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics, Inc.
    11/22/21
  125. 30
    Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit MNK1 and MNK2
    eFFECTOR Therapeutics, Inc.
    11/22/21
  126. 79
    Triazolopyrimidine, triazolopyridine compounds, and the composition thereof for treating PRC2-mediated diseases
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.
    11/22/21
  127. 202
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche Inc.
    11/22/21
  128. 25
    C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme Corp.
    11/15/21
  129. 155
    Compounds and methods for modulating interleukin-2-inducible t-cell kinase
    Corvus Pharmaceuticals, Inc.
    11/15/21
  130. 8
    Compounds useful for inhibiting RORγt
    Eli Lilly and Company
    11/15/21
  131. 8
    Cycloalkyl-diamines for the treatment of pain
    MediSynergics, LLC
    11/14/21
  132. 21
    Piperidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb Company
    11/14/21
  133. 359
    Pyridazine derivatives as RORc modulators
    Genentech, Inc.
    11/14/21
  134. 420
    Quinazolinones as PARP14 inhibitors
    Ribon Therapeutics Inc.
    11/14/21
  135. 85
    Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    11/14/21
  136. 15
    1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
    ASTRAZENECA AB
    11/08/21
  137. 8
    7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
    Eli Lilly and Company
    11/08/21
  138. 88
    Alkyl pyrrolopyrimidine analogs and methods of making and using same
    The University of North Carolina at Chapel Hill
    11/08/21
  139. 6
    Aminopyrimidinecarboxamides as CXCR2 modulators
    Syntrix Biosystems Inc.
    11/08/21
  140. 899
    Benzolactam compounds as protein kinase inhibitors
    OTSUKA PHARMACEUTICAL CO., LTD.
    11/08/21
  141. 11
    Compound useful for the treatment of degenerative and inflammatory diseases
    GALAPAGOS NV
    11/08/21
  142. 59
    Compounds and their uses as ACC inhibitors
    Nanjing Ruijie Pharmatech Co., Ltd.
    11/08/21
  143. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics LLC
    11/08/21
  144. 22
    Difluoroketamide derivatives as HTRA1 inhibitors
    Hoffman-La Roche Inc.
    11/08/21
  145. 16
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals, LLC
    11/08/21
  146. 13
    Disubstituted compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    11/08/21
  147. 44
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    11/08/21
  148. 92
    N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    KALVISTA PHARMACEUTICALS LIMITED
    11/08/21
  149. 51
    Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
    ASTRAZENECA AB
    11/08/21
  150. 13
    Pyrimidine compounds and pyrimido indole compounds and methods of use
    Duquesne University of The Holy Spirit
    11/08/21
  151. 10
    Pyrimidine derivative, method for preparing same and use thereof in medicine
    TBA
    11/08/21
  152. 136
    Pyrimidinone derivatives as SHP2 antagonists
    Merck Patent GmbH
    11/08/21
  153. 81
    SSAO inhibitor
    TBA
    11/08/21
  154. 15
    Acetyl-CoA carboxylase modulators
    Monsanto Technology LLC
    11/04/21
  155. 108
    EGFR proteolysis targeting chimeric molecules and associated methods of use
    ARVINAS OPERATIONS, INC.; YALE UNIVERSITY
    11/04/21
  156. 57
    Inhibitors of protease-activated receptor-2
    Heptares Therapeutics Limited
    11/04/21
  157. 162
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
    11/04/21
  158. 218
    PARG inhibitory compounds
    Cancer Research Technology Limited
    11/04/21
  159. 116
    Pyrrolidine derivative
    KISSEI PHARMACEUTICAL CO., LTD.
    11/04/21
  160. 19
    Substituted dihydrobenzofuran glycosidase inhibitors
    Asceneuron SA
    11/04/21
  161. 92
    Zaindole derivatives and their use as ERK kinase inhibitors
    AGV DISCOVERY; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE MONTPELLIER
    11/04/21
  162. 53
    1,2,4-triazine-4-amine derivatives
    Heptares Therapeutics Limited
    11/01/21
  163. 32
    Alpha-D-galactoside inhibitors of galectins
    GALECTO BIOTECH AB
    11/01/21
  164. 70
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    11/01/21
  165. 77
    Bicyclic lactams and methods of use thereof
    Genentech, Inc.
    11/01/21
  166. 136
    Compounds
    AstraZeneca AB
    11/01/21
  167. 99
    IRAK4 inhibitor and use thereof
    BEIJING HANMI PHARMACEUTICAL CO., LTD.
    11/01/21
  168. 2
    Immunomodulators
    bristol-myers squibb company
    11/01/21
  169. 23
    Inhibitors of influenza virus replication and uses thereof
    SUNSHINE LAKE PHARMA CO., LTD.
    11/01/21
  170. 440
    MCL-1 inhibitors
    Gilead Sciences, Inc.
    11/01/21
  171. 20
    Potent and selective mu opioid receptor modulators
    Virginia Commonwealth University
    11/01/21
  172. 37
    Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
    Japan Tobacco Inc.
    11/01/21
  173. 532
    Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
    Genentech, Inc.
    11/01/21
  174. 55
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer Inc.
    11/01/21
  175. 204
    Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme Corp.
    11/01/21
  176. 140
    Substituted pyrimidines as cyclin-dependent kinase inhibitors
    SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
    11/01/21
  177. 229
    Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
    Daewoong Pharmaceutical Co., Ltd.
    10/27/21
  178. 25
    Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
    DART NEUROSCIENCE, LLC
    10/27/21
  179. 1
    Substituted thiohydantoin derivatives as androgen receptor antagonists
    Janssen Pharmaceutica NV
    10/27/21
  180. 11
    Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Companay
    10/27/21
  181. 61
    1,3,4-thiadiazole compounds and their use in treating cancer
    Cancer Research Technology Limited
    10/26/21
  182. 18
    6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Purdue Research Foundation
    10/26/21
  183. 113
    Aminopyrimidinyl compounds
    Pfizer Inc.
    10/26/21
  184. 25
    Benzothiophene estrogen receptor modulators
    G1 Therapeutics, Inc.
    10/26/21
  185. 236
    Biaryl kinase inhibitors
    Bristol-Myers Squibb Company
    10/26/21
  186. 19
    Compound for inhibiting IDO, a manufacturing method and a use thereof
    Shanghai JOYU Pharmatech Ltd.
    10/26/21
  187. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    10/26/21
  188. 49
    Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    10/26/21
  189. 210
    Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
    Janssen Pharmaceutica NV
    10/26/21
  190. 22
    Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    10/26/21
  191. 5
    Inhibitors of soluble adenylyl cyclase
    Cornell University; Tri-Institutional Therapeutics Discovery Institute
    10/26/21
  192. 85
    Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
    ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
    10/26/21
  193. 329
    PRMT5 inhibitors and uses thereof
    Epizyme, Inc.
    10/26/21
  194. 51
    Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
    ACLARIS THERAPEUTICS, INC.
    10/26/21
  195. 30
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    10/26/21
  196. 164
    Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
    Bristol-Myers Squibb Company
    10/26/21
  197. 95
    Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
    BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    10/26/21
  198. 135
    4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
    TBA
    10/20/21
  199. 92
    6-aminopyridin-3-yl pyrazoles as modulators of RORgT
    Janssen Pharmaceutica NV
    10/20/21
  200. 440
    6-aminopyridin-3-yl thiazoles as modulators of RORγT
    Janssen Pharmaceutica NV
    10/20/21
  201. 25
    Bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    10/20/21
  202. 71
    Compounds and compositions for inhibiting the activity of SHP2
    NOVARTIS AG
    10/20/21
  203. 28
    Grp94 selective inhibitors and uses thereof
    University of Kansas; University of South Florida
    10/20/21
  204. 134
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent GmbH
    10/20/21
  205. 4
    Imidazolyl kinase inhibitors and uses thereof
    Dana-Farber Cancer Institute, Inc.
    10/20/21
  206. 185
    KDM5 inhibitors
    Merck Sharp & Dohme Corp.
    10/20/21
  207. 22
    Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    10/20/21
  208. 146
    Pharmaceutical compounds
    SENTINEL ONCOLOGY LIMITED
    10/20/21
  209. 225
    Phenyl substituted pyrazoles as modulators of RORγt
    Janssen Pharmaceutica NV
    10/20/21
  210. 150
    Pyridine derivative
    Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICAL CO., LTD.
    10/20/21
  211. 27
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    10/20/21
  212. 16
    Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    10/20/21
  213. 644
    Substituted pyridines as inhibitors of DNMT1
    GlaxoSmithKline Intellectual Property Development Limited; Cancer Research Technology Ltd.
    10/20/21
  214. 297
    4,5-annulated 1,2,4-triazolones
    BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    10/09/21
  215. 34
    Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
    The Research Foundation for the State University of New York
    10/09/21
  216. 114
    Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    1st Biotherapeutics, Inc.
    10/09/21
  217. 35
    Biaryltriazole inhibitors of macrophage migration inhibitory factor
    Yale University
    10/09/21
  218. 29
    Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    10/09/21
  219. 35
    Cyclopentane-based modulators of STING (stimulator of interferon genes)
    Pfizer Inc.
    10/09/21
  220. 107
    Cyclopropanamine compound and use thereof
    Takeda Pharmaceutical Company Limited
    10/09/21
  221. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    Proximagen, LLC
    10/09/21
  222. 45
    Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Vanderbilt University
    10/09/21
  223. 13
    Macrocyclic compounds as ROS1 kinase inhibitors
    Array BioPharma Inc.
    10/09/21
  224. 189
    Pyrido five-element aromatic ring compound, preparation method therefor and use thereof
    SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    10/09/21
  225. 273
    Pyrrolo[2,3-d]pyrimidine derivatives
    Pfizer Inc.
    10/09/21
  226. 13
    Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
    Incyte Corporation
    10/09/21
  227. 22
    Synergistic combination of immunologic inhibitors for the treatment of cancer
    The University of Chicago
    10/09/21
  228. 91
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    10/09/21
  229. 23
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    10/09/21
  230. 90
    USP30 inhibitors
    Mitobridge, Inc.
    10/09/21
  231. 63
    (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor
    AstraZeneca AB
    10/04/21
  232. 66
    Chemical compounds
    AstraZeneca AB
    10/04/21
  233. 80
    Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
    LegoChem Biosciences, Inc.
    10/04/21
  234. 66
    Farnesoid X receptor agonists and uses thereof
    METACRINE, INC.
    10/04/21
  235. 145
    Inhibiting agents for Bruton's tyrosine kinase
    BIOGEN MA INC.
    10/04/21
  236. 66
    JAK1 selective inhibitors
    ASTRAZENECA AB
    10/04/21
  237. 21
    Modulators of the sigma-2 receptor and their method of use
    TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    10/04/21
  238. 45
    Oxazole derivatives for use in the treatment of cancer
    LIFEARC
    10/04/21
  239. 3
    PRMT5 inhibitors
    CTXT PTY LTD
    10/04/21
  240. 180
    Pyrazolopyrimidine derivatives as kinase inhibitor
    Daewoong Pharmaceutical Co., Ltd.
    10/04/21
  241. 34
    Quinazoline and indole compounds to treat medical disorders
    Achillion Pharmaceuticals, Inc.
    10/04/21
  242. 512
    Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; THE UAB RESEARCH FOUNDATION; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    10/04/21
  243. 568
    Substituted pyrazines as ATR kinase inhibitors
    VERTEX PHARMACEUTICALS INCORPORATED
    10/04/21
  244. 119
    Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
    CELGENE QUANTICEL RESEARCH, INC.
    10/04/21
  245. 145
    1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; THE UAB RESEARCH FOUNDATION; VANDERBILT UNIVERSITY; NATIONAL INSTITUTES OF HEALTH, UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES
    09/28/21
  246. 75
    1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
    SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
    09/28/21
  247. 27
    Azaindoles as inhibitors of HPK1
    Genentech, Inc.
    09/28/21
  248. 90
    BMP-signal-inhibiting compound
    RIKEN; THE UNIVERSITY OF TOKYO
    09/28/21
  249. 11
    Compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    09/28/21
  250. 60
    Compounds inhibiting leucine-rich repeat kinase enzyme activity
    Merck Sharp & Dohme Corp.
    09/28/21
  251. 108
    Heterocyclic compounds as ret kinase inhibitors
    Cancer Research Technology Limited
    09/28/21
  252. 239
    Heterocyclic compounds for the inhibition of pask
    BioEnergenix LLC
    09/28/21
  253. 19
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D IP, LLC
    09/28/21
  254. 261
    Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Theravance Biopharma R&D IP, LLC
    09/28/21
  255. 97
    Methods of treating intraocular pressure with activators of Tie-2
    AERPIO PHARMACEUTICALS, INC.
    09/28/21
  256. 444
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica NV
    09/28/21
  257. 15
    Selective NR2B antagonists
    Bristol-Myers Squibb Company
    09/28/21
  258. 43
    Sigma receptor binders
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    09/28/21
  259. 22
    Substituted heterocyclic inhibitors of PTPN11
    NAVIRE PHARMA, INC.
    09/28/21
  260. 134
    Substituted indole Mcl-1 inhibitors
    Vanderbilt University
    09/28/21
  261. 556
    Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
    Array Biopharma Inc.
    09/28/21
  262. 88
    1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
    ST. JUDE CHILDREN''S RSEARCH HOSPITAL
    09/26/21
  263. 87
    Aminopyridine derivatives and their use as selective ALK-2 inhibitors
    NOVARTIS AG
    09/26/21
  264. 4
    Beta adrenergic agonist and methods of using the same
    CuraSen Therapeutics, Inc.
    09/26/21
  265. 54
    Bicyclic heterocycles as FGFR inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    09/26/21
  266. 23
    Bicyclic pyridone lactams and methods of use thereof
    Genentech, Inc.
    09/26/21
  267. 3
    Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body
    Pfizer Inc.; iTEOS THERAPEUTICS
    09/26/21
  268. 12
    Dimethyl amino azetidine amides as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    09/26/21
  269. 79
    Heteroaryl SYK inhibitors
    Boehringer Ingelheim International GmbH
    09/26/21
  270. 449
    Heteroaryl compounds and their use as therapeutic drugs
    Dong-A Socio Holdings Co., Ltd.
    09/26/21
  271. 72
    Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme Corp.
    09/26/21
  272. 135
    Inhibitors of Hepatitis C virus polymerase
    COCRYSTAL PHARMA, INC.
    09/26/21
  273. 547
    Inhibitors of KEAP1-Nrf2 protein-protein interaction
    Janssen Pharmaceutica NV
    09/26/21
  274. 33
    Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease
    TBA
    09/26/21
  275. 12
    PRMT5 inhibitors
    Merck Sharp & Dohme Corp.
    09/26/21
  276. 26
    Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
    Seoul National University Hospital
    09/26/21
  277. 18
    Substituted oxazines as beta-secretase inhibitors
    Amgen Inc.
    09/26/21
  278. 11
    Tank-binding kinase-1 PROTACs and associated methods of use
    ARVINAS OPERATIONS, INC.
    09/26/21
  279. 38
    Therapeutic compounds and methods of use thereof
    GENENTECH, INC.
    09/26/21
  280. 391
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    09/26/21
  281. 6
    Treatment and diagnosis of melanoma
    The Rockefeller University
    09/26/21
  282. 1
    [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
    Janssen Pharmaceutica NV
    09/26/21
  283. 26
    Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    09/20/21
  284. 499
    Bromodomain inhibitors
    Celgene Quanticel Research, Inc.
    09/20/21
  285. 29
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda SA
    09/20/21
  286. 25
    Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
    Shy Therapeutics LLC
    09/20/21
  287. 8
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    09/20/21
  288. 72
    Kinase inhibitors
    Oxular Acquisitions Limited
    09/20/21
  289. 31
    Methods for inhibiting fascin
    NOVITA PHARMACEUTICALS, INC.; CORNELL UNIVERSITY
    09/20/21
  290. 88
    Quinoline and isoquinoline derivatives for treating pain and pain related conditions
    ESTEVE PHARMACEUTICALS, S.A.
    09/20/21
  291. 131
    4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
    Merck Sharp & Dohme B.V.
    09/12/21
  292. 143
    5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
    Samumed, LLC
    09/12/21
  293. 28
    Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
    DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION; KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL; KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    09/12/21
  294. 214
    Bruton's tyrosine kinase inhibitors
    Suzhou Baijibugong Pharmaceutical Technology Co., Ltd.
    09/12/21
  295. 61
    Compounds and compositions for inhibiting the activity of SHP2
    NOVARTIS AG
    09/12/21
  296. 472
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica NV
    09/12/21
  297. 236
    Pyrazolopyridine compounds and uses thereof
    Incyte Corporation
    09/12/21
  298. 32
    SHMT inhibitors
    The Trustees of Princeton University
    09/12/21
  299. 288
    SHP2 phosphatase inhibitors and methods of use thereof
    Relay Therapeutics, Inc.
    09/12/21
  300. 87
    Spirocyclic compounds
    Recurium IP Holdings, LLC
    09/12/21
  301. 60
    Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
    Merck Sharp & Dohme Corp.
    09/12/21
  302. 44
    Benzothiazole derivatives as DYRK1 inhibitors
    PHARMASUM THERAPEUTICS AS
    09/06/21
  303. 45
    CDK inhibitors
    GI Therapeutics, Inc.
    09/06/21
  304. 31
    Cyano-subtituted heterocycles with activity as inhibitors of USP30
    MISSION THERAPEUTICS LIMITED
    09/06/21
  305. 48
    HSP90B N-terminal isoform-selective inhibitors
    University of Kansas
    09/06/21
  306. 62
    Inhibitors of RAF kinases
    KINNATE BIOPHARMA INC.
    09/06/21
  307. 69
    Intermediate compound of novel tetrahydronaphthyl urea derivative
    MOCHIDA PHARMACEUTICAL CO., LTD.
    09/06/21
  308. 35
    Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
    Arena Pharmaceuticals, Inc.
    09/06/21
  309. 112
    Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    ESTEVE PHARMACEUTICALS. S.A.
    09/06/21
  310. 248
    Pyrazole MAGL inhibitors
    LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    09/06/21
  311. 48
    Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
    Merck Sharp & Dohme Corp.
    09/06/21
  312. 7
    Treatment of conditions associated with hyperinsulinaemia
    Tensha Therapeutics, Inc.
    09/06/21
  313. 26
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The USA, as represented by the Secretary, Department of Health and Human Services; SRI International
    09/06/21
  314. 8
    Amide compounds for treatment of immune and inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    09/02/21
  315. 18
    Azetidine derivatives
    Vernalis (R&D) Ltd.
    09/02/21
  316. 56
    Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
    Boehringer Ingelheim International GmbH
    09/02/21
  317. 9
    Cannabidiol derivatives as inhibitors of the HIF prolyl hydroxylases activity
    Emerald Health Pharmaceuticals Inc.
    09/02/21
  318. 463
    Compounds and uses thereof
    Yumanity Therapeutics, Inc.
    09/02/21
  319. 18
    Cyclohexene compounds and use thereof
    GUANGZHOU HENOVCOM BIOSCIENCE CO. LTD.
    09/02/21
  320. 6
    Fused imidazoles as mIDH1 inhibitors
    BAYER PHARMA AKTIENGESELLSCHAFT
    09/02/21
  321. 23
    Hetero-halo inhibitors of histone deacetylase
    Alkermes, Inc.
    09/02/21
  322. 3
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    09/02/21
  323. 5
    Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    09/02/21
  324. 12
    Imidazopyrazine compounds, preparation methods and uses thereof
    DONGGUAN ZHENXING-BEITE MEDICINE TECHNOLOGY CO., LTD.
    09/02/21
  325. 407
    Immunomodulator compounds
    ChemoCentryx, Inc.
    09/02/21
  326. 68
    N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
    Nerviano Medical Sciences S.R.L.
    09/02/21
  327. 1
    Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    09/02/21
  328. 56
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
    Boehringer Ingelheim International GmbH
    09/02/21
  329. 51
    Substituted tricyclic heterocyclic compounds and use thereof
    LIFEARC; SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD.
    09/02/21
  330. 49
    Thiazole derivative and applications
    EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    09/02/21
  331. 70
    Thioacetate compounds, compositions and methods of use
    Ardea Biosciences, Inc
    09/02/21
  332. 37
    Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
    Bristol-Myers Squibb Company
    09/02/21
  333. 80
    Tricyclic ASK1 inhibitors
    TERNS, INC.
    09/02/21
  334. 99
    Benzene disulfonamide for the treatment of cancer
    Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    08/30/21
  335. 14
    Bis-heteroaryl derivatives as modulators of protein aggregation
    UCB Biopharma SRL
    08/30/21
  336. 107
    Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    08/30/21
  337. 16
    JAK kinase inhibitor compounds for treatment of respiratory disease
    Theravance Biopharma R&D IP, LLC
    08/30/21
  338. 20
    LRRK2 inhibitors and methods of making and using the same
    DANA-FARBER CANCER INSTITUTE, INC.
    08/30/21
  339. 47
    Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
    Hoffmann-La Roche Inc.
    08/30/21
  340. 110
    Oxadiazolones as transient receptor potential channel inhibitors
    Genentech, Inc.
    08/30/21
  341. 59
    Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    08/30/21
  342. 67
    Pyrimidine FGFR4 inhibitors
    EISAI R&D MANAGEMENT CO., LTD.
    08/30/21
  343. 111
    Substituted 4-phenylpiperidines, their preparation and use
    The Trustees of Columbia University in the City of New York
    08/30/21
  344. 50
    Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
    Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.
    08/30/21
  345. 219
    Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
    VALO EARLY DISCOVERY, INC.
    08/30/21
  346. 111
    Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    08/22/21
  347. 42
    Compositions and methods for inhibiting kinases
    Inhibikase Therapeutics, Inc.
    08/22/21
  348. 14
    Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D''ORLEANS; UNIVERSITE DE TOURS; CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    08/22/21
  349. 52
    Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/22/21
  350. 65
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    08/22/21
  351. 7
    Kinase inhibitors for the treatment of disease
    DANA FARBER CANCER INSTITUTE, INC.
    08/22/21
  352. 198
    Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
    Pfizer Inc.
    08/22/21
  353. 20
    Substituted piperazines as ROR-gamma modulators
    ESCALIER BIOSCIENCES B.V.
    08/22/21
  354. 370
    Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
    LEO Pharma A/S
    08/22/21
  355. 103
    Triazole phenyl compounds as agonists of the APJ receptor
    AMGEN INC.
    08/22/21
  356. 34
    IRAK4 modulators
    Genentech, Inc.
    08/16/21
  357. 71
    IRAK4 modulators
    Genentech, Inc.
    08/16/21
  358. 4
    3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/15/21
  359. 32
    Benzothiazole compounds and uses thereof
    Incyte Corporation
    08/15/21
  360. 33
    Imidazo isoindole derivative, preparation method therefor and medical use thereof
    JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHRMACEUTICAL CO., LTD.
    08/15/21
  361. 124
    Imidazopiperazinone inhibitors of transcription activating proteins
    Board of Regents, The University of Texas System
    08/15/21
  362. 110
    Inhibiting agents for Bruton's tyrosine kinase
    BIOGEN MA INC.
    08/15/21
  363. 427
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    08/15/21
  364. 23
    Phosphodiesterase inhibitors and uses thereof
    The Trustees of Columbia University in the City of New York
    08/15/21
  365. 378
    Piperidines as menin inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    08/15/21
  366. 38
    Pyrazine compounds and uses thereof
    TBA
    08/15/21
  367. 49
    Antitumor drug for intermittent administration of FGFR inhibitor
    Taiho Pharmaceutical Co., Ltd.
    08/14/21
  368. 51
    Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors
    Nikang Therapeutics, Inc.
    08/14/21
  369. 165
    Halo-substituted piperidines as orexin receptor modulators
    ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
    08/14/21
  370. 648
    Heteroarylbenzimidazole compounds
    BAYER PHARMA AKTIENGESELLSCHAFT
    08/14/21
  371. 35
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    08/14/21
  372. 19
    Indolizine derivatives, composition and methods of use
    SHANGHAI FOCHON PHARMACEUTICAL CO. LTD.; FOCHON PHARMACEUTICALS, LTD.
    08/14/21
  373. 161
    Inhibitors of cyclin-dependent kinases
    KINNATE BIOPHARMA INC.
    08/14/21
  374. 120
    Modulators of P97 AAA ATPase activity
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    08/14/21
  375. 4
    Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
    NANOMEDSYN; Centre National de la Recherche Scientifique; Universite de Montpellier
    08/14/21
  376. 102
    PSMA imaging agents
    Siemens Medical Solutions USA, Inc.
    08/14/21
  377. 3
    Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics
    King Abdulaziz University
    08/14/21
  378. 46
    Substituted pyrazole derivatives as selective CDK12/13 inhibitors
    Aurigene Discovery Technologies Limited
    08/14/21
  379. 74
    Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof
    Jiangsu Hengrui Medicine Co., Ltd.
    08/09/21
  380. 22
    Alpha-D-galactoside inhibitors of galectins
    GALECTO BIOTECH AB
    08/09/21
  381. 157
    Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
    Array BioPharma Inc.
    08/09/21
  382. 14
    CGRP receptor antagonists
    Heptares Therapeutics Limited
    08/09/21
  383. 32
    Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    08/09/21
  384. 40
    Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
    Amgen Inc.
    08/09/21
  385. 29
    Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
    ONCOZEN CO.. LTD.
    08/09/21
  386. 95
    Inhibitors of TRPC6
    Boehringer Ingelheim International GmbH
    08/09/21
  387. 78
    Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
    Auckland UniServices Limited
    08/09/21
  388. 69
    PDE9 inhibitor and use thereof
    Nanjing TransThera Biosciences Co. Ltd.
    08/09/21
  389. 215
    Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias
    Terns, Inc.
    08/09/21
  390. 268
    Sulfonamide compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    08/09/21
  391. 52
    Tetrahydroindazoles and medical uses thereof
    Genase Therapeutics B.V.
    08/09/21
  392. 17
    Thiazine derivatives as β-secretase inhibitors and methods of use
    Amgen Inc.
    08/09/21
  393. 21
    Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
    VALO EARLY DISCOVERY, INC.
    08/09/21
  394. 7
    [1,3]thiazin-2-amine compound, application, and pharmaceutical composition
    TETRANOV PHARMACEUTICAL CO., LTD.
    08/09/21
  395. 33
    Pyrazole derivatives as MALT1 inhibitors
    Janssen Pharmaceutica NV
    08/08/21
  396. 6
    Acetamide thienotriazolodiazepines and uses thereof
    Dana-Farber Cancer Institute, Inc.
    08/01/21
  397. 17
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche Inc.
    08/01/21
  398. 61
    Cannabinergic compounds and uses thereof
    NORTHEASTERN UNIVERSITY
    08/01/21
  399. 48
    Compounds useful as immunomodulators
    Bristol-Myers Squibb Company
    08/01/21
  400. 27
    KDM1A inhibitors for the treatment of disease
    Imago Biosciences, Inc.
    08/01/21
  401. 3
    Kinase inhibitors
    TOPIVERT PHARMA LIMITED
    08/01/21
  402. 22
    Pharmaceutical compounds
    Sareum Limited
    08/01/21
  403. 16
    Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    08/01/21
  404. 137
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International GmbH
    08/01/21
  405. 812
    Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    Array Biopharma Inc.
    08/01/21
  406. 19
    Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
    ONO PHARMACEUTICAL CO., LTD.
    08/01/21
  407. 8
    Tyrosine kinase inhibitor and application thereof
    LaNova Medicines Limited
    08/01/21
  408. 25
    Compounds and their use as BACE1 inhibitors
    ALLGENESIS BIOTHERAPEUTICS, INC.
    07/26/21
  409. 40
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Dana-Farber Cancer Institute, Inc.
    07/26/21
  410. 138
    Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
    SHIONOGI & CO., LTD.
    07/26/21
  411. 825
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics, Inc.
    07/26/21
  412. 18
    Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
    HANMI PHARM. CO.. LTD.
    07/26/21
  413. 10
    Zwitterionic propargyl-linked antifolates useful for treating bacterial infections
    UNIVERSITY OF CONNECTICUT
    07/26/21
  414. 9
    Aminopyrazoles as selective janus kinase inhibitors
    Intervet Inc.
    07/25/21
  415. 2
    Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
    INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB
    07/25/21
  416. 4
    Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
    Aristea Translational Medicine Corporation
    07/25/21
  417. 91
    Compositions and methods of modulating short-chain dehydrogenase activity
    CASE WESTERN RESERVE UNIVERSITY; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    07/25/21
  418. 23
    Compounds and methods for inhibiting CYP26 enzymes
    Queen''s University at Kingston
    07/25/21
  419. 90
    Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
    Boehringer Ingelheim International GmbH
    07/25/21
  420. 174
    Factor XIIa inhibitors
    MERCK SHARP & DOHME CORP.
    07/25/21
  421. 151
    Heteroaromatic compounds as BTK inhibitors
    Boehringer Ingelheim International GmbH
    07/25/21
  422. 3
    Highly active compounds against COVID-19
    Atea Pharmaceuticals, Inc.
    07/25/21
  423. 30
    Histone deacetylase inhibitors and uses thereof
    MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    07/25/21
  424. 26
    N4-hydroxycytidine and derivatives and anti-viral uses related thereto
    Emory University
    07/25/21
  425. 16
    Neuroprotective agents for treatment of neurodegenerative diseases
    WAYNE STATE UNIVERSITY
    07/25/21
  426. 22
    Phosphonate linkers and their use to facilitate cellular retention of compounds
    MERCK SHARP & DOHME CORP.
    07/25/21
  427. 34
    Pteridine dione monocarboxylate transporter inhibitors
    THE SCRIPPS RESEARCH INSTITUTE
    07/25/21
  428. 25
    RIPK2 inhibitors and method of treating cancer with same
    UNIVERSITY HEALTH NETWORK
    07/25/21
  429. 102
    Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
    SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC.
    07/25/21
  430. 3
    Substituted pyrimidines for treating bacterial infections
    FORGE THERAPEUTICS, INC.
    07/25/21
  431. 136
    Substituted pyrrolizine compounds and uses thereof
    GILEAD SCIENCES, INC.
    07/25/21
  432. 34
    Triazolopyridines
    Hoffmann-La Roche Inc.
    07/25/21
  433. 23
    Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
    Hoffmann-La Roche Inc.
    07/25/21
  434. 47
    2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
    Agency for Science, Technology and Research; National University of Singapore
    07/18/21
  435. 229
    ATG7 inhibitors and the uses thereof
    MILLENNIUM PHARMACEUTICALS, INC.
    07/18/21
  436. 3
    Dab2 inhibitors for the prevention and treatment of cystic fibrosis
    TRUSTEES OF DARTMOUTH COLLEGE
    07/18/21
  437. 17
    Difluoroketamide derivatives as HtrA1 inhibitors
    Hoffmann-La Roche Inc.
    07/18/21
  438. 57
    Heteroaromatic compounds as Vanin inhibitors
    Boehringer Ingelheim International GmbH
    07/18/21
  439. 15
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Syros Pharmaceuticals, Inc.
    07/18/21
  440. 75
    Inhibitors of lysine specific demethylase-1
    Celgene Quanticel Research, Inc.
    07/18/21
  441. 12
    Opioid agonists and uses thereof
    Nektar Therapeutics
    07/18/21
  442. 7
    Pet imaging agents
    Novartis AG
    07/18/21
  443. 39
    Biaryl urea derivative or salt thereof and preparation process and use for the same
    FUDAN UNIVERSITY
    07/13/21
  444. 116
    Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl
    Hoffmann-La Roche Inc.
    07/13/21
  445. 140
    Arf6 inhibitors and methods of synthesis and use thereof
    Navigen, Inc.; The University of Utah Research Foundation
    07/12/21
  446. 185
    Benzoimidazoles as prolyl hydroxylase inhibitors
    Janssen Pharmaceutica NV
    07/12/21
  447. 377
    Benzopyrazole compounds and analogues thereof
    BioCryst Pharmaceuticals, Inc.
    07/12/21
  448. 21
    Benzoxazepin oxazolidinone compounds and methods of use
    Genentech, Inc.
    07/12/21
  449. 43
    Bicyclic amines as novel JAK kinase inhibitors
    LEO Pharma A/S
    07/12/21
  450. 12
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    07/12/21
  451. 64
    C3-carbon linked glutarimide degronimers for target protein degradation
    C4 Therapeutics, Inc.
    07/12/21
  452. 92
    Heterocyclic inhibitors of PTPN11
    BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    07/12/21
  453. 52
    Imidazole and triazole containing bicyclic compounds as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    07/12/21
  454. 30
    Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
    Foresee Pharmaceuticals Co., Ltd.
    07/12/21
  455. 31
    Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds
    Array Biopharma Inc.
    07/12/21
  456. 3
    Pyridine compound
    Daiichi Sankyo Company, Limited
    07/12/21
  457. 227
    Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2)
    Northwestern University
    07/12/21
  458. 7
    Substituted bicyclic heterocyclic compounds
    Bristol-Myers Squibb Company
    07/12/21
  459. 118
    Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
    CELGENE QUANTICEL RESEARCH, INC.
    07/12/21
  460. 112
    Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
    Boehringer Ingelheim International GmbH
    07/11/21
  461. 26
    Diarylalkanes as potent inhibitors of binuclear enzymes
    Unigen, Inc.
    07/11/21
  462. 3
    HDAC inhibitors for the treatment of diabetic peripheral neuropathy
    REGENACY PHARMACEUTICALS, LLC
    07/11/21
  463. 6
    Heterocyclic ring derivatives useful as SHP2 inhibitors
    JACOBIO PHARMACEUTICALS CO., LTD.
    07/11/21
  464. 53
    Heterocyclic spiro compounds as MAGL inhibitors
    Pfizer Inc.
    07/11/21
  465. 20
    Hydantoin containing deoxyuridine triphosphatase inhibitors
    CV6 Therapeutics (NI) Limited
    07/11/21
  466. 3
    Imidazopyrazine inhibitors of Bruton's tyrosine kinase
    Acerta Pharma B.V.
    07/11/21
  467. 111
    Imidazopyrazinones as PDE1 inhibitors
    H. Lundbeck A/S
    07/11/21
  468. 34
    Inhibitors of phosphatidylinositol 3-kinase gamma
    AstraZeneca AB
    07/11/21
  469. 22
    Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
    TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; PRAEVENTIX, LLC
    07/11/21
  470. 5
    Oxazoline pseudodimers, pharmaceutical compositions and the use thereof
    PURDUE PHARMA L.P.
    07/11/21
  471. 80
    Pyrazolopyridine derivative having GLP-1 receptor agonist effect
    Chugai Seiyaku Kabushiki Kaisha
    07/11/21
  472. 98
    Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof
    UNIVERSITY OF MARYLAND, BALTIMORE
    07/11/21
  473. 119
    Triazolo-pyrimidine compounds and uses thereof
    TBA
    07/11/21
  474. 41
    Tricyclic compounds useful to treat orthomyxovirus infections
    Novartis AG
    07/11/21
  475. 16
    1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions
    SABILA BIOSCIENCES LLC
    07/06/21
  476. 63
    Fused amino pyridine as HSP90 inhibitors
    Curis, Inc.
    07/06/21
  477. 86
    Heterocyclic compounds as RET kinase inhibitors
    Cancer Research Technology Limited
    07/06/21
  478. 100
    Imidazopyridines Syk inhibitors
    KRONOS BIO, INC.
    07/06/21
  479. 13
    Process for preparing JAK inhibitors and intermediates thereof
    Theravance Biopharma R&D IP, LLC
    07/06/21
  480. 92
    Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof
    Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.
    07/06/21
  481. 146
    Pyrrolotriazine compounds as TAM inhibitors
    Incyte Corporation
    07/06/21
  482. 107
    Serine/threonine kinase inhibitors
    GENENTECH, INC.
    07/06/21
  483. 271
    Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors
    Vanderbilt University
    07/06/21
  484. 22
    Thiazolyl-containing compounds for treating proliferative diseases
    Dana-Farber Cancer Institute, Inc.
    07/06/21
  485. 359
    WDR5 inhibitors and modulators
    Vanderbilt University
    07/06/21
  486. 12
    5 to 7 membered heterocyclic amides as JAK inhibitors
    Theravance Biopharma R&D IP, LLC
    06/30/21
  487. 55
    5-HT2C receptor agonists and compositions and methods of use
    Arena Pharmaceuticals, Inc.
    06/30/21
  488. 6
    6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
    Eli Lilly and Company
    06/30/21
  489. 73
    Acyl sulfonamide NaV1.7 inhibitors
    BRISTOL-MYERS SQUIBB COMPANY
    06/30/21
  490. 57
    Bicyclic heterocyclic derivatives
    Merck Patent GmbH
    06/30/21
  491. 58
    Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    06/30/21
  492. 13
    Inhibitors of integrin alpha 5 beta 1 and methods of use
    The Regents of the University of California
    06/30/21
  493. 47
    N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
    Ogeda SA
    06/30/21
  494. 15
    N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
    Neomed Institute
    06/30/21
  495. 12
    Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
    Valo Early Discovery, Inc.
    06/30/21
  496. 11
    Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
    Mebias Discovery, Inc.
    06/30/21
  497. 55
    Substituted pyrrolizine compounds and uses thereof
    GILEAD SCIENCES, INC.
    06/30/21
  498. 50
    Therapeutic agent for FGFR inhibitor-resistant cancer
    Taiho Pharmaceutical Co., Ltd.
    06/30/21
  499. 22
    N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
    THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    06/29/21
  500. 51
    2,4-pyrimidinediamine compounds and their uses
    Rigel Pharmceuticals, Inc.
    06/28/21
  501. 153
    3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives
    GRUENENTHAL GMBH
    06/28/21
  502. 150
    5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis
    GALAPAGOS NV
    06/28/21
  503. 50
    Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
    06/28/21
  504. 155
    Aryl sulfonohydrazides
    MONASH UNIVERSITY; The Walter and Eliza Hall Institute of Medical Research
    06/28/21
  505. 189
    Benzimidazole derivatives as modulators of ROR-gamma
    Vitae Pharmaceuticals, LLC
    06/28/21
  506. 149
    Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors
    Boehringer Ingelheim International GmbH
    06/28/21
  507. 23
    Compositions and methods for treating KIT- and PDGFRA-mediated diseases
    Blueprint Medicines Corporation
    06/28/21
  508. 7
    Crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
    KRONOS BIO, INC.
    06/28/21
  509. 7
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    06/28/21
  510. 5
    Pyridyl-triazabicycles
    Hoffmann-La Roche Inc.
    06/28/21
  511. 82
    Pyrimidinones as PI3K inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    06/28/21
  512. 22
    Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof
    SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACAD
    06/28/21
  513. 244
    Substituted 2,4-diaminopyrimidines as kinase inhibitors
    Celgene CAR LLC
    06/28/21
  514. 111
    Substituted benzoimidazoles as modulators of ROR-γ
    Vitae Pharmaceuticals, LLC
    06/28/21
  515. 9
    Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents
    GI Therapeutics, Inc.
    06/28/21
  516. 108
    Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    06/28/21
  517. 27
    Thienopyridines and benzothiophenes useful as IRAK4 inhibitors
    Bristol-Myers Squibb Company
    06/28/21
  518. 103
    Thiophene, manufacturing method thereof, and pharmaceutical application of same
    CSTONE PHARMACEUTICAL (SUZHOU) CO., LTD.; CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD.; CSTONE PHARMACEUTICALS
    06/28/21
  519. 703
    Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    06/21/21
  520. 2
    Crystal of DPP-IV long-acting inhibitor and salt
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.
    06/21/21
  521. 30
    ErbB receptor inhibitors
    TBA
    06/21/21
  522. 789
    Inhibitors of Bruton's tyrosine kinase and methods of their use
    Janssen Pharmaceutica NV
    06/21/21
  523. 63
    KV1.3 inhibitors and their medical application
    4SC AG
    06/21/21
  524. 1
    Processes for preparing ATR inhibitors
    VERTEX PHARMACEUTICALS INCORPORATED
    06/21/21
  525. 37
    Pyrazolo[1,5-a]pyrazin-4-yl derivatives
    Pfizer Inc.
    06/21/21
  526. 12
    Pyrazolopyrimidine derivatives as NIK inhibitors
    Janssen Pharmaceutica NV
    06/21/21
  527. 74
    Substituted aminoquinazoline compounds as A2A antagonist
    Merck Sharp & Dohme Corp.
    06/21/21
  528. 797
    Compounds that inhibit Mcl-1 protein
    AMGEN INC.
    06/20/21
  529. 115
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    06/14/21
  530. 10
    Isoidide derivatives and methods of making and using same
    RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    06/14/21
  531. 10
    Optically active azabicyclo ring derivative
    Sumitomo Dainippon Pharma Co., Ltd.
    06/14/21
  532. 31
    1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
    Respivert Limited
    06/13/21
  533. 215
    2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION
    06/13/21
  534. 325
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    06/13/21
  535. 140
    Bruton's tyrosine kinase inhibitors
    Pfizer Inc.
    06/13/21
  536. 4
    Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
    Institute of Materia Medica, Chinese Academy of Medical Sciences; Tianjin Chase Sun Pharmaceutical Co., LTD
    06/13/21
  537. 90
    RIP1 inhibitory compounds and methods for making and using the same
    Rigel Pharmaceuticals, Inc.
    06/13/21
  538. 107
    Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
    Incyte Corporation; Incyte Holdings Corporation
    06/13/21
  539. 17
    Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
    Pfizer Inc.
    06/13/21
  540. 192
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    06/11/21
  541. 382
    3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    Grünenthal GmbH
    06/11/21
  542. 289
    3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GRÜNENTHAL GMBH
    06/11/21
  543. 104
    Bromodomain inhibitors
    Celgene Quanticel Research, Inc.
    06/11/21
  544. 59
    Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use
    Merck Sharp & Dohme Corp.
    06/11/21
  545. 124
    Compositions useful for treating disorders related to kit
    Blueprint Medicines Corporation
    06/11/21
  546. 101
    Compounds for treatment of immune inflammatory disorders
    Achillion Pharmaceuticals, Inc.
    06/11/21
  547. 51
    Dihydrochromene derivatives
    Sumitomo Dainippon Pharma Co., Ltd.
    06/11/21
  548. 156
    Dihydropyrrolopyridine inhibitors of ROR-gamma
    Vitae Pharmaceuticals, LLC
    06/11/21
  549. 200
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    06/11/21
  550. 42
    HDAC inhibitor compounds and methods of treatment
    University of Florida Research Foundation, Inc.; The Scripps Research Institute
    06/11/21
  551. 97
    Heterocyclic compounds and uses thereof
    NUVATION BIO INC.
    06/11/21
  552. 16
    Heterocyclic compounds as kinase inhibitors
    Translational Drug Development, LLC
    06/11/21
  553. 101
    Histone demethylase inhibitors
    CELGENE QUANTICEL RESEARCH, INC.
    06/11/21
  554. 191
    Immunomodulator compounds and methods of use
    Incyte Corporation
    06/11/21
  555. 161
    Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
    The Institute of Cancer Research: Royal Cancer Hospital
    06/11/21
  556. 28
    Protease inhibitors having enhanced features
    Nektar Therapeutics
    06/11/21
  557. 17
    Pyrrolidinone compounds
    Eli Lilly and Company
    06/11/21
  558. 51
    Selective androgen receptor degrader (SARD) ligands and methods of use thereof
    University of Tennessee Research Foundation
    06/11/21
  559. 42
    Spiro-cyclic amine derivatives as S1P modulators
    AbbVie B.V.; AbbVie, Inc.
    06/11/21
  560. 260
    WDR5-MLL1 inhibitors and modulators
    Vanderbilt University
    06/11/21
  561. 38
    2,6-disubstituted pyridine derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    06/01/21
  562. 20
    4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors
    NERVIANO MEDICAL SCIENCES S.R.L.
    06/01/21
  563. 155
    5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
    Leo Pharma A/S
    06/01/21
  564. 20
    Arylpropionyl-triketone antibacterial agents
    TBA
    06/01/21
  565. 40
    Beta-lactamase inhibitor compounds
    Entasis Therapeutics Limited
    06/01/21
  566. 32
    Bicyclic compounds as ATX inhibitors
    Hoffman-La Roche Inc.
    06/01/21
  567. 218
    CDK2/4/6 inhibitors
    Pfizer Inc.
    06/01/21
  568. 105
    Carboxamide compounds and uses thereof
    Incyte Corporation
    06/01/21
  569. 22
    Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor
    TBA
    06/01/21
  570. 7
    Conjugate comprising a neurotensin receptor ligand and use thereof
    3B Pharmaceuticals GMBH
    06/01/21
  571. 25
    Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    06/01/21
  572. 138
    Heterocyclic compounds as LSD1 inhibitors
    Incyte Corporation
    06/01/21
  573. 266
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    06/01/21
  574. 122
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    06/01/21
  575. 32
    Heterocyclic inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    06/01/21
  576. 12
    Hybrid galactoside inhibitor of galectins
    TBA
    06/01/21
  577. 41
    Imidazole derivatives as formyl peptide receptor modulators
    ALLERGAN, INC.
    06/01/21
  578. 62
    Indole derivative used as CRTH2 inhibitor
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    06/01/21
  579. 912
    Inhibitors of Bruton's tyrosine kinase and method of their use
    Janssen Pharmaceutica NV
    06/01/21
  580. 94
    Inhibitors of TRPC6
    Boehringer Ingelheim International GmbH; Hydra Biosciences, LLC
    06/01/21
  581. 9
    Methotrexate adjuvants to reduce toxicity and methods for using the same
    Tosk, Inc.
    06/01/21
  582. 123
    Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof
    JAPAN TOBACCO INC.
    06/01/21
  583. 11
    Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
    BAYER PHARMA AKTIENGESELLSCHAFT
    06/01/21
  584. 7
    Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
    ACLARIS THERAPEUTICS, INC.
    06/01/21
  585. 6
    Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Janssen Pharmaceutica NV
    06/01/21
  586. 85
    Substituted pyrrolo[2,3-d]pyridazin-4-ones and pyrazolo[3,4-d]pyridazin-4-ones as protein kinase inhibitors
    Shanghai Fochon Pharmaceutical Co., Ltd.; Fochon Pharmaceuticals, Ltd.
    06/01/21
  587. 7
    Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders
    Northwestern University
    06/01/21
  588. 36
    Thyroid hormone receptor beta agonist compounds
    Terns, Inc.
    06/01/21
  589. 179
    Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
    ALLERGAN, INC.
    06/01/21
  590. 2
    1,8-naphthyridinone compounds and uses thereof
    NUVATION BIO INC.
    05/14/21
  591. 73
    3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GRÜNENTHAL GMBH
    05/14/21
  592. 34
    8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
    GRUENENTHAL GMBH
    05/14/21
  593. 144
    Amino acid compounds and methods of use
    PLIANT THERAPEUTICS, INC.
    05/14/21
  594. 3
    Amino pyrimidine ssao inhibitors
    ELI LILLY AND COMPANY
    05/14/21
  595. 84
    Bicyclic heterocyclic compound
    MITSUBISHI TANABE PHARMA CORPORATION
    05/14/21
  596. 15
    Bicyclic inhibitors of histone deacetylase
    Rodin Therapeutics, Inc.
    05/14/21
  597. 361
    Bicyclic-fused heteroaryl or aryl compounds
    Pfizer Inc.
    05/14/21
  598. 123
    Bruton's tyrosine kinase inhibitors
    ZIBO BIOPOLAR CHANGSHENG PHARMACEUTICAL CO. LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    05/14/21
  599. 126
    Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof
    CHENGDU BRILLIANT PHARMACEUTICAL CO., LTD.; CHENGDU HIGHBRED PHARMACEUTICAL CO., LTD.
    05/14/21
  600. 502
    GCN2 inhibitors and uses thereof
    MERCK PATENT GMBH; VERTEX PHARMACEUTICALS INCORPORATED
    05/14/21
  601. 19
    Glutamine transport inhibitors and methods for treating cancer
    Vanderbilt University
    05/14/21
  602. 4
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    05/14/21
  603. 45
    Heterocyclic glutaminase inhibitors
    Calithera Biosciences, Inc.
    05/14/21
  604. 336
    Hormone receptor modulators for treating metabolic conditions and disorders
    ARDELYX, INC.
    05/14/21
  605. 59
    Oxoisoquinoline derivatives
    CARNA BIOSCIENCES, INC.
    05/14/21
  606. 7
    Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
    HANGZHOU ZHENGXIANG PHARMACEUTICALS CO., LTD.
    05/14/21
  607. 22
    Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
    Bayer Pharma Aktiengesellschaft
    05/14/21
  608. 15
    Substituted nucleosides, nucleotides and analogs thereof
    Janssen BioPharma, Inc.
    05/14/21
  609. 310
    Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
    LEO Pharma A/S
    05/14/21
  610. 4
    Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators
    ARENA PHARMACEUTICALS, INC.
    05/14/21
  611. 59
    Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof
    SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.; YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
    05/14/21
  612. 217
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/14/21
  613. 555
    Compounds useful as inhibitors of ATR kinase
    VERTEX PHARMACEUTICALS INCORPORATED
    05/11/21
  614. 56
    ASK1 inhibitor and preparation method and use thereof
    Fuijan Cosunter Pharmaceutical Co. Ltd.
    05/09/21
  615. 9
    Benzopiperdine derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY, LTD
    05/09/21
  616. 3
    Bicyclic compounds as ATX inhibitors
    Hoffmann-La Roche Inc.
    05/09/21
  617. 90
    Cannabinoid receptor mediating iminopyrazole compounds
    The United States of America, as represented by the Secretary, Department of Health and Human Services
    05/09/21
  618. 78
    Fused pyrimidine compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    05/09/21
  619. 40
    Inhibitors of cyclin-dependent kinase 7 (CDK7)
    Dana-Farber Cancer Institute, Inc.
    05/09/21
  620. 2
    Octahydropyrrolopyrroles their preparation and use
    The Trustees of Columbia University in the City of New York
    05/09/21
  621. 23
    Prodrugs of pyridone amides useful as modulators of sodium channels
    Vertex Pharmaceuticals Incorporated
    05/09/21
  622. 253
    Spiro-fused cyclic ureas as inhibitors of rock
    Bristol-Myers Squibb Company
    05/09/21
  623. 18
    Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
    Pfizer Inc.
    05/09/21
  624. 105
    Thiazolidinedione derivative and use thereof
    INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY
    05/09/21
  625. 93
    1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
    Incyte Corporation
    05/03/21
  626. 2
    2,6-diamino pyridine compounds
    Eli Lilly and Company
    05/03/21
  627. 4
    3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    Arena Pharmaceuticals, Inc.
    05/03/21
  628. 10
    Azetidinyloxyphenylpyrrolidine compounds
    Eli Lilly and Company
    05/03/21
  629. 6
    Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
    ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.
    05/03/21
  630. 108
    Heterocyclic compounds for the inhibition of PASK
    BioEnergenix LLC
    05/03/21
  631. 108
    N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
    KALVISTA PHARMACEUTICALS LIMITED
    05/03/21
  632. 260
    Spirocycle compounds and methods of making and using same
    LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    05/03/21
  633. 163
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    05/03/21
  634. 137
    Therapeutic inhibitory compounds
    ATTUNE PHARMACEUTICALS, INC.
    05/03/21
  635. 25
    Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    05/02/21
  636. 151
    Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
    Merck Sharp & Dohme Corp.
    05/02/21
  637. 352
    Heteroaryl compounds useful as inhibitors of SUMO activating enzyme
    Millennium Pharmaceuticals, Inc.
    05/02/21
  638. 3
    Macrocycle and composition comprising thereof
    Shenzhen TargetRx, Inc.
    05/02/21
  639. 7
    Mu opioid receptor modulators
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FRIEDRICH-ALEXANDER-UNIVERSITÄT; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    05/02/21
  640. 287
    Substituted pyrrolidines as G-protein coupled receptor 43 agonists
    Epics Therapeutics
    05/02/21
  641. 242
    1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
    H. Lundbeck A/S
    04/26/21
  642. 83
    2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
    Array Biopharma Inc.
    04/26/21
  643. 9
    Aminopyrazoles as janus kinase inhibitors
    Merck Sharp & Dohme Corp.
    04/26/21
  644. 13
    Aza-indazole compounds for use in tendon and/or ligament injuries
    NOVARTIS AG
    04/26/21
  645. 137
    Cyclin dependent kinase inhibitors
    Pfizer Inc.
    04/26/21
  646. 155
    Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
    PROXIMAGEN, LLC
    04/26/21
  647. 106
    Morphinan derivatives for the treatment of neuropathic pain
    Nektar Therapeutics
    04/26/21
  648. 243
    Piperidine derivatives as inhibitors of ubiquitin specific protease 7
    ALMAC DISCOVERY LIMITED
    04/26/21
  649. 19
    Substituted benzamides and methods of use thereof
    GENENTECH, INC.; XENON PHARMACEUTICALS INC.
    04/26/21
  650. 33
    Sulfonylcycloalkyl carboxamide compounds
    Genentech, Inc.
    04/26/21
  651. 43
    Trk-inhibiting compound
    ONO PHARMACEUTICAL CO., LTD.
    04/26/21
  652. 96
    Wee-1 inhibiting pyrazolopyrimidinone compounds
    ALMAC DISCOVERY LIMITED
    04/26/21
  653. 22
    1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
    NOVARTIS AG
    04/25/21
  654. 432
    2-(morpholin-4-yl)-1,7-naphthyridines
    BAYER PHARMA AKTIENGESELLSCHAFT
    04/25/21
  655. 39
    2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
    BLUEPRINT MEDICINES CORPORATION
    04/25/21
  656. 1204
    6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
    SHIONOGI & CO., LTD.
    04/25/21
  657. 123
    Composition and methods for inhibiting mammalian sterile 20-like kinase 1
    THE SCRIPPS RESEARCH INSTITUTE; UNIVERSITÄT BREMEN
    04/25/21
  658. 3
    Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
    PHARMAKEA, INC.
    04/25/21
  659. 8
    FXR (NR1H4) modulating compounds
    Gilead Sciences, Inc.
    04/25/21
  660. 106
    Galactoside inhibitor of galectins
    Galecto Biotech AB
    04/25/21
  661. 352
    HIV protease inhibitors
    Gilead Sciences, Inc.
    04/25/21
  662. 191
    Heteroaryl compounds and uses thereof
    Celgene CAR LLC; Sanofi
    04/25/21
  663. 54
    Indazole compounds and uses thereof
    Incyte Corporation
    04/25/21
  664. 24
    Materials and method for inhibiting replication protein A and uses thereof
    Indiana University Research and Technology Corporation
    04/25/21
  665. 105
    Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    ARRAY BIOPHARMA INC.
    04/25/21
  666. 381
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    04/25/21
  667. 71
    Substituted piperazines as selective HDAC1,2 inhibitors
    REGENACY PHARMACEUTICALS, INC.
    04/25/21
  668. 343
    ULK1 inhibitors and methods using same
    SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; YALE UNIVERSITY
    04/25/21
  669. 43
    Compounds that are ERK inhibitors
    Merck Sharp & Dohme Corp.
    04/19/21
  670. 20
    Indazole containing macrocycles and therapeutic uses thereof
    Samumed, LLC
    04/19/21
  671. 220
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/19/21
  672. 15
    Thienopyrimidine derivative and use thereof in medicine
    Sunshine Lake Pharma Co., Ltd.
    04/19/21
  673. 106
    2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors
    Almirall, S.A.
    04/18/21
  674. 77
    2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
    BAYER PHARMA AKTIENGESELLSCHAFT
    04/18/21
  675. 33
    Benzofuran derivative, preparation method thereof and use thereof in medicine
    Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
    04/18/21
  676. 138
    CXCR4 inhibitors and uses thereof
    X4 PHARMACEUTICALS, INC.
    04/18/21
  677. 26
    CaMKII inhibitors and uses thereof
    The Johns Hopkins University
    04/18/21
  678. 138
    Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
    Synchronicity Pharma, Inc.
    04/18/21
  679. 20
    Carboxamide derivatives useful as rsk inhibitors
    PHOENIX MOLECULAR DESIGNS
    04/18/21
  680. 32
    Certain chemical entities, compositions, and methods
    NEUPHARMA, INC.
    04/18/21
  681. 46
    Glucosylceramide synthase inhibitors for the treatment of diseases
    TBA
    04/18/21
  682. 24
    Mammalian and bacterial nitric oxide synthase inhibitors
    Northwestern University
    04/18/21
  683. 2
    Pharmaceutical uses of pyridine carboxamide derivatives
    JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.
    04/18/21
  684. 232
    Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors
    Array BioPharma Inc.
    04/18/21
  685. 7
    Therapeutic compounds and uses thereof
    Kala Pharmaceuticals, Inc.
    04/18/21
  686. 8
    1,3,5-triazine derivative and method of using same
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd.
    04/13/21
  687. 66
    6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
    Samumed, LLC
    04/13/21
  688. 6
    Adenosine A3 receptor modulators
    Palobiofarma, S.L.
    04/13/21
  689. 19
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    04/13/21
  690. 190
    Condensed lactam derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    04/13/21
  691. 57
    Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
    Merck Patent GmbH
    04/13/21
  692. 16
    Indazole compounds and uses thereof
    Incyte Corporation
    04/13/21
  693. 2
    Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
    CTXT PTY LTD
    04/13/21
  694. 18
    Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents
    ZENJI RESEARCH LABORATORIES
    04/13/21
  695. 420
    Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
    Lycera Corporation; Merck Sharp & Dohme Corp.
    04/13/21
  696. 96
    Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
    Board of Regents, The University of Texas System; ChemPartner Corporation
    04/13/21
  697. 40
    Neprilysin inhibitors
    Theravance Biopharma R&D IP, LLC
    04/12/21
  698. 5
    PPARG modulators for the treatment of osteoporosis
    The Scripps Research Institute; The University of Toledo
    04/12/21
  699. 75
    4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
    Eastern Virginia Medical School; The Regents of the University of California Santa; The United States of America Department of Health; Thomas Jefferson University
    04/11/21
  700. 6
    6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds
    Eli Lilly and Company
    04/11/21
  701. 20
    Aryldiazepine derivatives as RSV inhibitors
    Enanta Pharmaceuticals, Inc.
    04/11/21
  702. 46
    Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
    King''s College London
    04/11/21
  703. 20
    C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
    Je II Pharmaceutical Co., Ltd.
    04/11/21
  704. 15
    Compounds and their use for reducing uric acid levels
    Acquist LLC
    04/11/21
  705. 27
    Dopamine D2 receptor ligands
    The Broad Institute, Inc.; Massachusetts Institute of Technology
    04/11/21
  706. 62
    Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
    Xenon Pharmaceuticals Inc.
    04/11/21
  707. 12
    Heterocyclic compounds as FGFR inhibitors
    Guangzhou Innocare Pharma Tech Co., Ltd.
    04/11/21
  708. 25
    Iso-citrate dehydrogenase (IDH) inhibitor
    SHANGHAI METON PHARMACEUTICAL CO., LTD
    04/11/21
  709. 38
    Morphan and morphinan analogues, and methods of use
    ALKERMES PHARMA IRELAND LIMITED
    04/11/21
  710. 152
    Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
    JAPAN TOBACCO INC.
    04/11/21
  711. 28
    Signaling-biased mu opioid receptor agonists
    THE SCRIPPS RESEARCH INSTITUTE
    04/11/21
  712. 148
    Spirocyclic containing compounds and pharmaceutical uses thereof
    GB005, Inc.
    04/11/21
  713. 14
    Substituted aminopyrimidine compounds and methods of use
    SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC
    04/11/21
  714. 42
    1,3-diaza-spiro-[3.4]-octane derivatives
    GRÜNENTHAL GMBH
    04/04/21
  715. 64
    6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
    Pfizer Inc.
    04/04/21
  716. 97
    Amide compounds as kinase inhibitors, compositions and methods of treatment
    Translation Drug Development, LLC
    04/04/21
  717. 33
    Apoptosis signal-regulating kinase inhibitors
    Gilead Sciences, Inc.
    04/04/21
  718. 96
    Benzimidazole derivatives: preparation and pharmaceutical applications
    MEI Pharma, Inc.
    04/04/21
  719. 4
    Bicyclic compounds as dual ATX/CA inhibitors
    Hoffmann-La Roche Inc.
    04/04/21
  720. 37
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    04/04/21
  721. 29
    Cyclic di-nucleotide compounds as STING agonists
    Merck Sharp & Dohme Corp.
    04/04/21
  722. 204
    Imidazotriaines and imidazopyrimidines as kinase inhibitors
    INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
    04/04/21
  723. 11
    Isoquinoline derivatives and use thereof
    Purdue Pharma L.P.
    04/04/21
  724. 37
    Methods for treating depressive symptoms
    ALKERMES PHARMA IRELAND LIMITED
    04/04/21
  725. 508
    Pyrazolopyrimidinone compounds and uses thereof
    Aduro BioTech Inc.
    04/04/21
  726. 158
    Pyridone amides as modulators of sodium channels
    VERTEX PHARMACEUTICALS INCORPORATED
    04/04/21
  727. 35
    Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
    THE JOHNS HOPKINS UNIVERSITY
    04/04/21
  728. 118
    Tertiary alcohols as PI3K-γ inhibitors
    Incyte Corporation
    04/04/21
  729. 315
    Triazole furan compounds as agonists of the APJ receptor
    AMGEN INC.
    04/04/21
  730. 242
    Biphenyl compound or salt thereof
    Taiho Pharmaceutical Co., Ltd.
    03/30/21
  731. 5
    1,1 ′-sulfanediyl-di-beta-D-galactopyranosides as inhibitors of galectins
    GALECTO BIOTECH AB
    03/28/21
  732. 380
    Amido spirocyclic amide and sulfonamide derivatives
    FORMA TM, LLC; Genentech, Inc.
    03/28/21
  733. 230
    Biaryl kinase inhibitors
    Bristol-Myers Squibb Company
    03/28/21
  734. 51
    Cyanoindazole compounds and uses thereof
    Incyte Corporation
    03/28/21
  735. 4
    Cyclodextrin-panobinostat adduct
    MIDATECH LTD.
    03/28/21
  736. 10
    D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof
    Peking University
    03/28/21
  737. 204
    Heterocyclic compounds and uses thereof
    Incyte Corporation
    03/28/21
  738. 6
    Protease inhibitors
    MEDIVIR AB
    03/28/21
  739. 173
    Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors
    Bristol-Myers Squibb Company
    03/28/21
  740. 34
    2-aminoquinazoline derivatives as P70S6 kinase inhibitors
    SENTINEL ONCOLOGY LIMITED
    03/27/21
  741. 199
    4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors
    Array BioPharma Inc.; Celgene Corporation
    03/27/21
  742. 841
    4-Azaindole compounds
    Bristol-Myers Squibb Company
    03/27/21
  743. 95
    Bicyclic heteroaryl substituted compounds
    Bristol-Myers Squibb Company
    03/27/21
  744. 140
    Compounds and methods for the enhanced degradation of targeted proteins
    ARVINAS OPERATIONS, INC.; YALE UNIVERSITY
    03/27/21
  745. 49
    Compounds for modulating aquaporins
    APOGLYX AB
    03/27/21
  746. 2
    Diaminopyrimidine benzenesulfone derivatives and uses thereof
    Dana-Farber Cancer Institute, Inc.
    03/27/21
  747. 28
    Fused pyrimidine derivatives
    HOFFMANN-LA ROCHE, INC.
    03/27/21
  748. 72
    Indole derivatives and use thereof
    Purdue Pharma L.P.
    03/27/21
  749. 296
    Inhibitors of plasma kallikrein and uses thereof
    Shire Human Genetic Therapies, Inc.
    03/27/21
  750. 31
    Substituted imidazo[1,2-A]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof
    JN Therapeutics
    03/27/21
  751. 63
    5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
    BAYER PHARMA AKTIENGESELLSCHAFT
    03/21/21
  752. 130
    Aliphatic prolinamide derivatives
    ORION OPHTHALMOLOGY LLC
    03/21/21
  753. 12
    Alkynyl dihydroquinoline sulfonamide compounds
    AMGEN INC.
    03/21/21
  754. 29
    Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof
    The Research Foundation for the State University of New York; New York University
    03/21/21
  755. 12
    Benzimidazole derivatives as EP4 ligands
    BAYER PHARMA AKTIENGESELLSCHAFT
    03/21/21
  756. 51
    Benzo[b]thiophene compounds as STING agonists
    Merck Sharp & Dohme Corp.
    03/21/21
  757. 427
    Bridged bicyclic compounds as farnesoid X receptor modulators
    Bristol-Myers Squibb Company
    03/21/21
  758. 6
    Catecholamine prodrugs for use in the treatment of Parkinson's disease
    H. Lundbeck A/S
    03/21/21
  759. 86
    Chemical compounds
    ASTRAZENECA AB
    03/21/21
  760. 17
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    XW LABORATORIES INC.
    03/21/21
  761. 115
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    03/21/21
  762. 116
    Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis Ltd.
    03/21/21
  763. 44
    Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof
    Pharmaxis Ltd.
    03/21/21
  764. 17
    Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
    University Health Network
    03/21/21
  765. 68
    Ketone inhibitors of lysine gingipain
    CORTEXYME, INC.
    03/21/21
  766. 31
    Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Bristol-Myers Squibb Company
    03/21/21
  767. 106
    Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
    Boehringer Ingelheim International GmbH
    03/21/21
  768. 29
    Pyrimidinone and its derivatives inhibiting factor XIa
    ONO PHARMACEUTICAL CO., LTD.
    03/21/21
  769. 137
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International GmbH
    03/21/21
  770. 9
    Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
    Wisconsin Alumni Research Foundation
    03/21/21
  771. 25
    Tetrahydronaphthalene derivative
    ONO PHARMACEUTICAL CO., LTD.
    03/21/21
  772. 207
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    03/21/21
  773. 59
    Treatment of infectious diseases with glucose uptake inhibitors
    KADMON CORPORATION, LLC
    03/21/21
  774. 87
    MALT1 inhibitors and uses thereof
    Cornell University; Dana-Farber Cancer Institute, Inc.; Children''s Medical Center Corporation
    03/15/21
  775. 28
    Selective Bruton's tyrosine kinase inhibitor and use thereof
    HANGZHOU HERTZ PHARMACEUTICAL CO., LTD.
    03/15/21
  776. 49
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    03/15/21
  777. 783
    Tricyclic sulfones as RORγ modulators
    Bristol-Myers Squibb Company
    03/15/21
  778. 16
    Agent for treating synucleinopathy
    Tohoku University; National University Corporation Okayama University
    03/14/21
  779. 88
    Aminopyridine derivatives and their use as selective ALK-2 inhibitors
    Novartis AG
    03/14/21
  780. 1072
    Biaryl amide compounds as kinase inhibitors
    NOVARTIS AG
    03/14/21
  781. 2
    Compounds as rearranged during transfection (RET) inhibitors
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    03/14/21
  782. 28
    Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
    Metabasis Therapeutics, Inc.
    03/14/21
  783. 150
    Oxadiazole transient receptor potential channel inhibitors
    Genentech, Inc.
    03/14/21
  784. 275
    Oxadiazole transient receptor potential channel inhibitors
    Genentech, Inc.
    03/14/21
  785. 656
    PD-1/PD-L1 inhibitors
    Gilead Sciences, Inc.
    03/14/21
  786. 294
    Pyrimidine derivative
    ASKA PHARMACEUTICAL CO., LTD.
    03/14/21
  787. 59
    STK4 inhibitors for treatment of hematologic malignancies
    DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE
    03/14/21
  788. 10
    Substituted bicyclic compounds
    Bristol-Myers Squibb Company
    03/14/21
  789. 203
    Substituted carbonucleoside derivatives useful as anticancer agents
    Pfizer Inc.
    03/14/21
  790. 17
    3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA
    NOVARTIS AG
    03/11/21
  791. 43
    5-hydroxytryptamine receptor 7 activity modulators and their method of use
    Temple University Of The Commonwealth System of Higher Education
    03/11/21
  792. 11
    Antidiabetic bicyclic compounds
    Merch Sharp & Dohne Corp. Rahway
    03/11/21
  793. 58
    Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
    Washington University
    03/11/21
  794. 129
    Cyclopropylamines as LSD1 inhibitors
    Incyte Corporation
    03/11/21
  795. 94
    GLP-1 receptor agonists and uses thereof
    Pfizer Inc.
    03/11/21
  796. 118
    Imidazolepyridine compounds and uses thereof
    Novartis AG
    03/11/21
  797. 34
    Inhibitors of lysine gingipain
    CORTEXYME, INC.
    03/11/21
  798. 182
    Kappa opioid receptor antagonists and products and methods related thereto
    BLACKTHORN THERAPEUTICS, INC.; THE SCRIPPS RESEARCH INSTITUTE
    03/11/21
  799. 53
    Macrocyclic MCL-1 inhibitors and methods of use
    AbbVie Inc.
    03/11/21
  800. 3
    Quinazolines as potassium ion channel inhibitors
    Bristol-Myers Squibb Company
    03/11/21
  801. 14
    Small-molecule HSP90 inhibitors
    Sloan-Kettering Institute for Cancer Research
    03/11/21
  802. 190
    Bicyclic quinazolinone derivatives
    Hoffmann-La Roche Inc.
    03/10/21
  803. 178
    Carbazole derivatives
    Bristol-Myers Squibb Company
    03/10/21
  804. 109
    Heterocyclic compounds and uses thereof
    Infinity Pharmaceuticals, Inc.
    03/10/21
  805. 196
    Indole derivatives and their use in neurodegenerative diseases
    Merck Patent GmbH
    03/10/21
  806. 10
    KCNQ2-5 channel activator
    Ono Pharmaceutical Co., Ltd.
    03/10/21
  807. 127
    Phenylpyrrolidinone formyl peptide 2 receptor agonists
    Bristol-Myers Squibb Company
    03/10/21
  808. 169
    Somatostatin receptor subtype 4 (SSTR4) agonists
    Centrexion Therapeutics Corporation
    03/10/21
  809. 37
    Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
    Incyte Corporation
    03/10/21
  810. 7
    Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof
    Leo Pharma A/S
    03/08/21
  811. 16
    Covalent inhibitors of PAD4
    Padlock Therapeutics, Inc.
    03/08/21
  812. 21
    Degradation of tripartite motif-containing protein 24 (TRIM24) by conjugation of TRIM24 inhibitors with E3 ligase ligand and methods of use
    DANA-FARBER CANCER INSTITUTE, INC.
    03/08/21
  813. 445
    MCL-1 inhibitors
    Gilead Sciences, Inc.
    03/08/21
  814. 15
    MU opioid receptor modulators
    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NÜRNBERG; THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    03/08/21
  815. 289
    P2X7 modulators
    Janssen Pharmaceutica NV
    03/08/21
  816. 1
    Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
    GALAPAGOS NV
    03/08/21
  817. 14
    Substituted benzimidazoles, their preparation and their use as pharmaceuticals
    Neomed Institute
    03/08/21
  818. 337
    Substituted purine derivative
    SUMITOMO DAINIPPON PHARMA CO., LTD.
    03/08/21
  819. 308
    Amido-benzyl sulfone and sulfoxide derivates
    TBA
    03/02/21
  820. 152
    Amino acid compounds and methods of use
    Pliant Therapeutics, Inc.
    03/02/21
  821. 44
    CDK inhibitors
    G1 Therapeutics, Inc.
    03/02/21
  822. 69
    Compounds
    Exonate Limited
    03/02/21
  823. 43
    Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same
    INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    03/02/21
  824. 57
    Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
    Boehringer Ingelheim International GmbH
    03/02/21
  825. 64
    Kinase inhibitor, and preparing method and pharmaceutical use thereof
    GAN & LEE PHARMACEUTICALS
    03/02/21
  826. 23
    Mutant IDH1 inhibitors
    Eli Lilly and Company
    03/02/21
  827. 388
    Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
    Incyte Holdings Corporation; Incyte Corporation
    03/02/21
  828. 40
    Pyrimidine derivative and use thereof
    HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC.
    03/02/21
  829. 36
    Rho kinase inhibitors
    Kadmon Corporation, LLC
    03/02/21
  830. 23
    Somatostatin modulators and uses thereof
    CRINETICS PHARMACEUTICALS, INC.
    03/02/21
  831. 125
    Therapeutic compounds and uses thereof
    GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.
    03/02/21
  832. 149
    1,2-substituted cyclopentanes as orexin receptor antagonists
    TAKEDA PHARMACEUTICAL COMPANY LIMITED
    02/22/21
  833. 269
    1-cyano-pyrrolidine compounds as USP30 inhibitors
    Mission Therapeutics Limited
    02/22/21
  834. 25
    C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme Corp.
    02/22/21
  835. 71
    FGFR3 fusion gene and pharmaceutical drug targeting same
    Chugai Seiyaku Kabushiki Kaisha
    02/22/21
  836. 246
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    02/22/21
  837. 13
    Macrocylic compounds as ROS1 kinase inhibitors
    Array BioPharma Inc.
    02/22/21
  838. 647
    Methods, compositions, and uses of novel Fyn kinase inhibitors
    TBA
    02/22/21
  839. 43
    N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof
    NORTHEASTERN UNIVERSITY
    02/22/21
  840. 89
    OXA-Diazaspiro compounds having activity against pain
    ESTEVE PHARMACEUTICALS, S.A.
    02/22/21
  841. 64
    Piperazine-substituted benzothiophenes for treatment of mental disorders
    Otsuka Pharmaceutical Co., Ltd.
    02/22/21
  842. 15
    Prodrug amino acid derivative
    TAISHO PHARMACEUTICAL CO., LTD.
    02/22/21
  843. 69
    Pyrrolidine derivatives
    Hoffmann-La Roche Inc.
    02/22/21
  844. 124
    Quinoxaline compounds as type III receptor tyrosine kinase inhibitors
    Development Center for Biotechnology
    02/22/21
  845. 23
    Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections
    Gilead Sciences, Inc.
    02/22/21
  846. 127
    Substituted indazole compounds as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme Corp.
    02/22/21
  847. 39
    Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
    Stingray Therapeutics, Inc.; The University of Utah
    02/22/21
  848. 206
    Therapeutically active compounds and their methods of use
    Agios Pharmaceuticals, Inc.
    02/22/21
  849. 233
    Triazole pyridyl compounds as agonists of the APJ receptor
    AMGEN INC.
    02/22/21
  850. 18
    Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer
    JUBILANT BIOSYS LIMITED
    02/22/21
  851. 14
    Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
    JUBILANT BIOSYS LIMITED
    02/22/21
  852. 242
    5-substituted indazole-3-carboxamides and preparation and use thereof
    Samumed, LLC
    02/21/21
  853. 115
    Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
    1ST Biotherapeutics, Inc.
    02/21/21
  854. 306
    Bicyclic derivatives
    Hoffmann-La Roche Inc.
    02/21/21
  855. 104
    Boronic acid derivatives
    MERCK PATENT GMBH
    02/21/21
  856. 37
    Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides dipeptidyl peptidase 1 inhibitors
    ASTRAZENECA AB
    02/21/21
  857. 43
    Condensed [1,4] diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffmann-La Roche Inc.
    02/21/21
  858. 48
    Fused pyrimidine derivatives
    HOFFMANN-LA ROCHE INC.
    02/21/21
  859. 30
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    02/21/21
  860. 104
    Imidazopyridazine compounds
    Pfizer Inc.
    02/21/21
  861. 10
    Isoxazole carboxamides as irreversible SMYD inhibitors
    EPIZYME, INC.
    02/21/21
  862. 4
    LXR agonists and uses thereof
    Rgenix, Inc.
    02/21/21
  863. 72
    Pyridyl benzothiophenes as kinase inhibitors
    ALLERGAN, INC.
    02/21/21
  864. 39
    Substituted N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and N-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives P2X7 receptor antagonists
    Axxam S.P.A.
    02/21/21
  865. 36
    Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
    Peking University
    02/21/21
  866. 67
    5-5 fused rings as C5a inhibitors
    ChemoCentryx, Inc.
    02/16/21
  867. 29
    Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
    Ogeda SA
    02/16/21
  868. 3
    Heterocyclic compounds for the treatment of disease
    OPPILAN PHARMA LTD.
    02/16/21
  869. 80
    Tricyclic compounds as anticancer agents
    Bristol-Myers Squibb Company
    02/16/21
  870. 42
    Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
    MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V.
    02/16/21
  871. 100
    (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
    BAYER PHARMA AKTIENGESELLSCHAFT
    02/15/21
  872. 17
    (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using
    Iowa State University Research Foundation, Inc.
    02/15/21
  873. 68
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    02/15/21
  874. 23
    Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    02/15/21
  875. 100
    Compound having mutant IDH inhibitory activity, preparation method and use thereof
    SHANGHAI HAIHE PHARMACEUTICAL CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    02/15/21
  876. 9
    Curcumin analogues as zinc chelators and their uses
    THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
    02/15/21
  877. 147
    Cyanopyrrolidines as dub inhibitors for the treatment of cancer
    MISSION THERAPEUTICS LIMITED
    02/15/21
  878. 62
    Glucocorticoid receptor agonist and immunoconjugates thereof
    AbbVie Inc.
    02/15/21
  879. 45
    Heterocyclic derivatives and their use in the treatment of neurological disorders
    Novartis AG
    02/15/21
  880. 55
    Indole derivatives and their use as protein kinase inhibitors
    RESPIVERT LIMITED
    02/15/21
  881. 56
    Modulators of calcium release-activated calcium channel
    RHIZEN PHARMACEUTICALS SA
    02/15/21
  882. 4
    Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
    ARENA PHARMACEUTICALS, INC.
    02/15/21
  883. 135
    Pyridine sulfonamides
    AMGEN INC.
    02/15/21
  884. 21
    Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Yeda Research and Development Co. Ltd.
    02/15/21
  885. 68
    Tetrahydronaphthyl urea derivative
    MOCHIDA PHARMACEUTICAL CO., LTD.
    02/15/21
  886. 841
    Pyridyl substituted indole compounds
    Bristol-Myers Squibb Company
    02/08/21
  887. 60
    ABHD6 and dual ABHD6/MGL inhibitors and their uses
    MAKSCIENTIFIC, LLC
    02/07/21
  888. 89
    Amino compounds for treatment of medical disorders
    Achillion Pharmaceuticals, Inc.
    02/07/21
  889. 83
    Benzenesulfonamide compounds and their use as therapeutic agents
    Xenon Pharmaceuticals Inc.
    02/07/21
  890. 27
    Benzimidazole derivatives as PI3 kinase inhibitors
    GLAXOSMITHKLINE LLC
    02/07/21
  891. 124
    Bruton's tyrosine kinase inhibitors
    Zibo Biopolar Changsheng Pharmaceutical Co. Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    02/07/21
  892. 90
    Guanidine derivative and medical use thereof
    Toray Industries, Inc.
    02/07/21
  893. 78
    PDE4 inhibitor
    SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.
    02/07/21
  894. 137
    Substituted pyrimidines as cyclin-dependent kinase inhibitors
    SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
    02/07/21
  895. 90
    ASK1 isoindolin-1-one inhibitors and methods of use thereof
    Hepatikos Therapeutics, LLC
    02/01/21
  896. 7
    Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Hoffman-La Roche Inc.
    02/01/21
  897. 69
    Compounds and methods for inhibiting JAK
    Dizal (Jiangsu) Pharmaceutical Co., Ltd.
    02/01/21
  898. 17
    Method for preparing pyrrolo[3,2-D]pyrimidine compound, and intermediates thereof
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    02/01/21
  899. 73
    Protein kinase B inhibitors
    AstraZeneca AB
    02/01/21
  900. 10
    Pyrimidine derivative, method for preparing same and use thereof in medicine
    Zhejiang Hisun Pharmaceutical Co., Ltd.
    02/01/21
  901. 21
    Selective estrogen receptor degraders
    Eli Lilly and Company
    02/01/21
  902. 145
    Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
    MISSION THERAPEUTICS LIMITED
    02/01/21
  903. 31
    Tricyclic rho kinase inhibitors
    Bristol-Myers Squibb Company
    02/01/21
  904. 143
    6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed, LLC
    01/31/21
  905. 14
    Antiproliferative pyrimidine-based compounds
    G1 Therapeutics, Inc.
    01/31/21
  906. 127
    Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity
    KANCERA AB
    01/31/21
  907. 52
    Substituted quinazolines for inhibiting kinase activity
    NEUPHARMA, INC.
    01/31/21
  908. 33
    Biaryl urea derivative or salt thereof and preparation process and use for the same
    Fudan University
    01/25/21
  909. 5
    Bicyclic compounds as dual ATX/CA inhibitors
    Hoffmann-La Roche Inc.
    01/25/21
  910. 14
    Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies
    GALDERMA RESEARCH & DEVELOPMENT
    01/25/21
  911. 40
    Diphenylaminopyrimidine and triazine compound, and pharmaceutical composition and use thereof
    ARROMAX PHARMATECH CO., LTD.
    01/25/21
  912. 14
    EZH2 inhibitor and use thereof
    TARAPEUTICS SCIENCE INC.
    01/25/21
  913. 3
    Heterocyclic degronimers for target protein degradation
    C4 Therapeutics, Inc.
    01/25/21
  914. 342
    Heterocyclylamines as PI3K inhibitors
    Incyte Corporation; Incyte Holdings Corporation
    01/25/21
  915. 333
    Pyrimido-pyridazinone compounds and methods of use thereof
    Asan BioSciences, LLC
    01/25/21
  916. 47
    Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
    Merck Sharp & Dohme Corp.
    01/25/21
  917. 50
    Substituted pyrimidines for preventing or treating cancer and inflammatory diseases
    KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    01/25/21
  918. 601
    TYK2 inhibitors and uses thereof
    Nimbus Lakshmi, Inc.
    01/25/21
  919. 46
    Tetrahydroisoquinoline derived PRMT5-inhibitors
    CTXT PTY. LTD
    01/25/21
  920. 172
    Alkoxy compounds for disease treatment
    ACUCELA INC.
    01/18/21
  921. 68
    Compounds
    MISSION THERAPEUTICS LIMITED
    01/18/21
  922. 19
    Epoxyketone compounds for enzyme inhibition
    CENTRAX INTERNATIONAL, INC.
    01/18/21
  923. 85
    Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
    Boehringer Ingelheim International GmbH
    01/18/21
  924. 615
    Heterocycle derivatives having TrkA inhibitory activity
    Shionogi & Co., Ltd.
    01/18/21
  925. 158
    Imidazopyridines and imidazopyrazines as LSD1 inhibitors
    Incyte Corporation
    01/18/21
  926. 312
    Immunomodulator compounds
    ChemoCentryx, Inc.
    01/18/21
  927. 20
    Inhibitors of bruton's tyrosine kinase
    HOFFMANN-LA ROCHE INC.
    01/18/21
  928. 205
    Therapeutically active compositions and their methods of use
    Agios Pharmaceuticals, Inc.
    01/18/21
  929. 113
    Diazaspirocycloalkane and azaspirocycloalkane
    Hoffmann-La Roche Inc.
    01/12/21
  930. 168
    Bicyclic heterocycles as FGFR4 inhibitors
    Incyte Corporation
    01/10/21
  931. 130
    Bromodomain inhibitors
    AbbVie Inc.
    01/10/21
  932. 1023
    CARM1 inhibitors and uses thereof
    Epizyme, Inc.
    01/10/21
  933. 115
    Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases
    University of Washington
    01/10/21
  934. 248
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    01/10/21
  935. 130
    Melanocortin receptor-specific peptides
    Palatin Technologies, Inc.
    01/10/21
  936. 16
    Methods to treat lymphoplasmacytic lymphoma
    Dana-Farber Cancer Institute, Inc.
    01/10/21
  937. 107
    Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
    Jinagsu Hengrui Medicine Co., Ltd; Shanghai Hengrui Pharmaceutical Co., Ltd.
    01/10/21
  938. 14
    Pyrazolopyrimidone derivatives and methods of use thereof
    Shanghai Hengrui Pharmaceutical Co., ltd.; Jiangsu Hangrui Medicine Co., Ltd.
    01/10/21
  939. 72
    Pyridyl benzothiophenes as kinase inhibitors
    Allergan, Inc.
    01/10/21
  940. 150
    6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
    Samumed, LLC
    12/21/20
  941. 19
    C5-C6-oxacyclic fused iminothiadiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
    Merck Sharp & Dohme Corp.
    12/21/20
  942. 240
    Compounds, compositions and methods
    Denali Therapeutics Inc.
    12/21/20
  943. 11
    Enhancer of zeste homolog 2 inhibitors
    GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
    12/21/20
  944. 54
    Substituted cyclopropanes as PDE-10 inhibitors
    Sunovion Pharamaceuticals Inc.
    12/21/20
  945. 11
    2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
    CrystalGenomics, Inc.
    12/20/20
  946. 12
    2-amino-6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
    H. Lundbeck A/S
    12/20/20
  947. 20
    3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2, 7-dione compounds for the treatment and prophylaxis of virus infection
    Hoffmann-La Roche Inc.
    12/20/20
  948. 27
    5-aromatic alkynyl substituted benzamide compound and preparation method, pharmaceutical composition, and use thereof
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    12/20/20
  949. 43
    6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
    University of Pittsburgh—Of the Commonwealth System of Higher Education
    12/20/20
  950. 65
    Arginase inhibitors as therapeutics
    Mars, Incorporated
    12/20/20
  951. 17
    Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    XW LABORATORIES INC.
    12/20/20
  952. 171
    Compounds for the treatment of pain
    Alkermes, Inc.
    12/20/20
  953. 3
    Compounds useful for inhibiting ROR-gamma-t
    Eli Lilly and Company
    12/20/20
  954. 1
    Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
    Suzhou Zelgen Biopharmaceuticals Co., Ltd.
    12/20/20
  955. 18
    Diaryl macrocycles as modulators of protein kinases
    Turning Point Therapeutics, Inc.
    12/20/20
  956. 262
    Heteroaryl substituted aminopyridine compounds
    Bristol-Myers Squibb Company
    12/20/20
  957. 68
    Heterocyclic compounds as immunomodulators
    Incyte Corporation
    12/20/20
  958. 222
    Indole carboxamide compounds
    Bristol-Myers Squibb Company
    12/20/20
  959. 37
    Macrocycles as PDE1 inhibitors
    H. Lundbeck A/S
    12/20/20
  960. 161
    Spiroindolinones as DDR1 inhibitors
    Hoffmann-La Roche Inc.
    12/20/20
  961. 111
    Substituted 5-cyanoindole compounds and uses thereof
    Novartis AG
    12/20/20
  962. 249
    Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
    Celgene CAR LLC; Sanofi
    12/20/20
  963. 29
    Tricyclic heterocycles as BET protein inhibitors
    Incyte Corporation
    12/20/20
  964. 35
    Bicyclic proline compounds
    Genentech, Inc.
    12/14/20
  965. 8
    Methods to treat lymphoplasmacytic lymphoma
    Dana-Farber Cancer Institute, Inc.
    12/14/20
  966. 39
    Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    12/14/20
  967. 15
    Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
    Enanta Pharmaceuticals, Inc.
    12/14/20
  968. 259
    2,4-disubstituted pyrimidines useful as kinase inhibitors
    Celgene CAR LLC
    12/13/20
  969. 325
    Aryl ethers and uses thereof
    Peloton Therapeutics, Inc.
    12/13/20
  970. 76
    Aza-heteroaryl compounds as PI3K-gamma inhibitors
    Incyte Corporation
    12/13/20
  971. 8
    Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
    Jenrin Discovery, LLC
    12/13/20
  972. 42
    Compounds for cancer chemotherapeutic sensitization
    REGENTS OF THE UNIVERSITY OF MINNESOTA; THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    12/13/20
  973. 191
    Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    12/13/20
  974. 5
    Methods and compositions for cell-proliferation-related disorders
    Agios Pharmaceuticals, Inc.
    12/13/20
  975. 4
    Pyrrolopyrimidine comprising cyclopentyl substituent
    CENTAURUS BIOPHARMA CO.; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
    12/13/20
  976. 258
    Somatostatin modulators and uses thereof
    CRINETICS PHARMACEUTICALS, INC.
    12/13/20
  977. 594
    Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GluN2B receptor modulators
    JANSSEN PHARMACEUTICA NV
    12/13/20
  978. 397
    Therapeutic compounds
    CELGENE QUANTICEL RESEARCH, INC.
    12/13/20
  979. 26
    Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
    The USA, as represented by the Secretary, Department of Health and Human Services; SRI International
    12/13/20
  980. 6
    Certain chemical entities, compositions, and methods
    NeuPharma, Inc.
    12/08/20
  981. 56
    1,3-dihydroxy-phenyl derivatives useful as immunomodulators
    Bristol-Meyers Squibb Company
    12/07/20
  982. 18
    1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
    UNIVERSITAT DE BARCELONA; FUNACIÓ INSTITUT DE RECERCA BIOMÉDICA; IPROTEOS S.L.
    12/07/20
  983. 212
    Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
    Janssen Pharmaceutica NV
    12/07/20
  984. 14
    Cardiac glycoside analogs and their use in methods for inhibition of viral infection
    The John Hopkins University
    12/07/20
  985. 63
    Chemical compounds
    AstraZeneca AB
    12/07/20
  986. 161
    Compounds, compositions, and methods
    Denali Therapautics Inc.
    12/07/20
  987. 26
    Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
    GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.
    12/07/20
  988. 29
    Cyanopyrrolidine derivatives as inhibitors for DUBs
    MISSION THERAPEUTICS LIMITED
    12/07/20
  989. 15
    Dopamine D1 receptor positive allosteric modulators
    Eli Lilly and Company
    12/07/20
  990. 24
    Heterocyclic compounds used as FGFR inhibitors
    Nanjing InnoCare Pharma Tech Co., Ltd.
    12/07/20
  991. 114
    Histone demethylase inhibitors
    Celgene Quanticel Research, Inc.
    12/07/20
  992. 69
    Imidazopyridazine compounds and their use
    HUTCHISON MEDIPHARMA LIMITED
    12/07/20
  993. 97
    Isoindoline compositions and methods for treating neurodegenerative disease
    COGNITION THERAPEUTICS, INC.
    12/07/20
  994. 60
    Method of treatment using substituted imidazo[1,2b]pyridazine compounds
    Array BioPharma Inc.
    12/07/20
  995. 95
    Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
    Loxo Oncology Inc.
    12/07/20
  996. 159
    Selective estrogen receptor down-regulators
    AstraZeneca AB
    12/07/20
  997. 7
    TRPV4 antagonists
    GlaxoSmithKline Intellectual Property Development Limited
    12/07/20
  998. 438
    Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions
    ESTEVE PHARMACEUTICALS, S.A.
    12/07/20
  999. 16
    (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
    Centrexion Therapeutics Corporation
    11/30/20
  1000. 53
    1,4-dicarbonyl-piperidyl derivatives
    Merck Patent GmbH
    11/30/20
  1001. 22
    Compounds and compositions as protein kinase inhibitors
    Array BioPharma Inc.
    11/30/20
  1002. 149
    Ectonucleotidase inhibitors and methods of use thereof
    Calithera Biosciences, Inc.
    11/30/20
  1003. 8
    Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
    KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    11/30/20
  1004. 40
    Isoquinolones as BTK inhibitors
    Boehringer Ingelheim International GmbH
    11/30/20
  1005. 51
    Pharmacokinetically improved compounds
    SURFACE LOGIX, LLC
    11/30/20
  1006. 42
    Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
    Prelude Therapeutics Incorporated
    11/30/20
  1007. 7
    Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
    Marquette University; Concordia University Inc.
    11/30/20
  1008. 114
    Substituted dihydroisoquinolinone compounds
    Pfizer Inc.
    11/30/20
  1009. 42
    Substituted imidazo[1,2-a]pyridines as PDE-10 inhibitors
    SUNOVION PHARMACEUTICALS INC.
    11/30/20
  1010. 7
    Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof
    CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
    11/30/20
  1011. 138
    Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
    Merck Sharp & Dohme Corp.
    11/30/20
  1012. 13
    Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
    vTv Therapeutics LLC
    11/30/20
  1013. 11
    3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
    Rugen Holdings (Cayman) Limited
    11/29/20
  1014. 22
    4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
    Heptares Therapeutics Limited
    11/29/20
  1015. 61
    A3 adenosine receptor agonists
    The United States of America, as represented by the Secretary, Department of Health and Human Services; Saint Louis University
    11/29/20
  1016. 58
    Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease
    National Health Research Institutes; Academia Sinica
    11/29/20
  1017. 356
    Bruton's tyrosine kinase inhibitors
    Sunesis Pharmaceuticals, Inc.; Biogen MA Inc.
    11/29/20
  1018. 18
    Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof
    TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.
    11/29/20
  1019. 10
    Heteroaryl substituted benzoic acids as RORgammaT inhibitors and uses thereof
    Merck Sharp & Dohme Corp.
    11/29/20
  1020. 51
    Heterocyclic sulfonamide derivative and medicine containing same
    EA Pharma Co., Ltd.
    11/29/20
  1021. 8
    Indane-amines as PD-L1 antagonists
    ChemoCentryx, Inc.
    11/29/20
  1022. 12
    Ingenol analogs, pharmaceutical compositions and methods of use thereof
    GlaxoSmithKline Intellectual Property Development Limited
    11/29/20
  1023. 41
    Inhibitors of RET
    BLUEPRINT MEDICINES CORPORATION
    11/29/20
  1024. 37
    Macrocyclic inhibitors of myeloperoxidase
    Bristol-Myers Squibb Company
    11/29/20
  1025. 12
    Quinolone-3-diarylethers
    Oregon Health & Science University
    11/29/20
  1026. 12
    SHMT inhibitors
    The Trustees of Princeton University
    11/29/20
  1027. 211
    Small molecule agonists of neurotensin receptor 1
    SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    11/29/20
  1028. 174
    Substituted 3,6-diazabicyclo[3.2.0]heptanes
    INDIVIOR UK LIMITED
    11/29/20
  1029. 1143
    TYK2 inhibitors and uses thereof
    Nimbus Lakshimi, Inc.
    11/29/20
  1030. 56
    Triazole DAGLα inhibitors
    THE SCRIPPS RESEARCH INSTITUTE; LEIDEN UNIVERSITY
    11/29/20
  1031. 69
    Use of physiological cooling active ingredients, and agents containing such active ingredients
    SYMRISE AG; BASF SE
    11/29/20
  1032. 73
    4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
    Takeda Pharmaceutical Company Limited
    11/22/20
  1033. 22
    Benzimidazoles derivatives as Tec kinases family inhibitors
    GB005, INC.
    11/22/20
  1034. 15
    Cancer therapeutics
    UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    11/22/20
  1035. 14
    Carboxylic acid compounds
    Sumitomo Dainippon Pharma Co., Ltd.
    11/22/20
  1036. 63
    Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-HT1A receptors
    NEUROLIXIS; UNIVERSITE JAGELLONE
    11/22/20
  1037. 1
    Crystalline FGFR4 inhibitor compound and uses thereof
    Eisai R&D Management Co., LTD.
    11/22/20
  1038. 222
    Cycloalkylamines as monoamine reuptake inhibitors
    SUNOVION PHARAMCEUTICALS INC.
    11/22/20
  1039. 14
    HYPDH inhibitors and methods of use for the treatment of kidney stones
    Wake Forest University Health Sciences; UAB Research Foundation
    11/22/20
  1040. 100
    Human plasma kallikrein inhibitors
    BioCryst Pharmaceuticals, Inc.
    11/22/20
  1041. 164
    IRAK4 inhibitor and use thereof
    Beijing Hanmi Pharmaceutical Co., Ltd.
    11/22/20
  1042. 57
    Indazole compounds as FGFR kinase inhibitor, preparation and use thereof
    Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    11/22/20
  1043. 9
    Nitrogen-containing tricyclic compounds and uses thereof in medicine
    NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED
    11/22/20
  1044. 5
    Organic compounds
    INTRA-CELLULAR THERAPIES, INC.
    11/22/20
  1045. 41
    Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions
    Takeda Pharmaceutical Company Limited
    11/22/20
  1046. 16
    Prolyl hydroxylase inhibitors
    AERPIO THERAPEUTICS, INC.
    11/22/20
  1047. 23
    Pyrrolopyrimidine compound
    Centaurus Biophrama Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.
    11/22/20
  1048. 427
    Quinazolinones as PARP14 inhibitors
    Ribon Therapeutics Inc.
    11/22/20
  1049. 27
    SHP2 inhibitors and uses thereof
    SYNBLia Therapeutics, Inc.
    11/22/20
  1050. 206
    Substituted quinoxalines as PDE-10 inhibitors
    Sunovion Pharmaceuticals, Inc.
    11/22/20
  1051. 177
    Triazolones and tetrazolones as inhibitors of ROCK
    Bristol-Myers Squibb Company
    11/22/20
  1052. 508
    IRAK4 inhibiting agents
    BIOGEN MA INC.
    11/21/20
  1053. 11
    2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
    Genentech, Inc.
    11/20/20
  1054. 27
    5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
    ViiV HEALTHCARE UK (NO.5) LIMITED
    11/20/20
  1055. 153
    Arylamide derivatives having multimodal activity against pain
    ESTEVE PHARMACEUTICALS, S.A.
    11/20/20
  1056. 6
    Bis-pyridazine compounds and their use in treating cancer
    Cancer Research Technology Limited
    11/20/20
  1057. 37
    Cot modulators and methods of use thereof
    Gilead Sciences, Inc.
    11/20/20
  1058. 33
    Dopamine D3 receptor antagonists having a morpholine moiety
    INDIVIOR UK LIMITED
    11/20/20
  1059. 43
    Ether compounds for treatment of complement mediated disorders
    Achillion Pharmaceuticals, Inc.
    11/20/20
  1060. 58
    Fused tricyclic compounds as Raf kinase inhibitors
    BEIGENE, LTD.
    11/20/20
  1061. 159
    Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators
    NOVARTIS AG
    11/20/20
  1062. 20
    Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
    Boehringer Ingelheim International GmbH
    11/20/20
  1063. 24
    JAK inhibitors containing a 4-membered heterocyclic amide
    Theravance Biopharma R&D IP, LLC
    11/20/20
  1064. 21
    Kinase inhibitors and their use in cancer therapy
    TECHNISCHE UNIVERSITÄT DORTMUND
    11/20/20
  1065. 28
    Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
    Saint Louis University
    11/20/20
  1066. 87
    Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
    Boehringer Ingelheim International GmbH
    11/20/20
  1067. 221
    NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
    Ogeda SA
    11/20/20
  1068. 5
    Prodrugs of imidazotriazine compounds as CK2 inhibitors
    Bristol-Myers Squibb Company
    11/20/20
  1069. 803
    Pyridazinones as PARP7 inhibitors
    Ribon Therapeutics Inc.
    11/20/20
  1070. 36
    Sodium channel modulators
    The Florey Institute; The University of Melbourne
    11/20/20
  1071. 107
    Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
    Boehringer Ingelheim International GmbH
    11/20/20
  1072. 980
    Substituted piperidine compounds
    EPIZYME, INC.
    11/20/20
  1073. 3
    Tetrahydroisoquinolines as PRMT5 inhibitors
    CTXT PTY LTD
    11/20/20
  1074. 9
    Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics
    GALDERMA RESEARCH & DEVELOPMENT
    11/13/20
  1075. 122
    Glycosidase inhibitors
    Asceneuron SA
    11/13/20
  1076. 302
    Isoquinolin-3-YL carboxamides and preparation and use thereof
    Samumed, LLC
    11/13/20
  1077. 37
    Piperazinyl methanone NAAA inhibitors
    The Regents of the University of California; Fondazione Istituto Italiano di Technologia
    11/13/20
  1078. 119
    Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
    Incyte Corporation
    11/13/20
  1079. 100