The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.5M data for 1.1M Compounds and 8.8K Targets. Of those, 1,112K data for 512K Compounds and 4.3K Targets were curated by BindingDB curators.

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Recently Added Targets

    1. glucose-dependent insulinotropic receptor, Golden hamster, A0A1U8CD06 (Curated 03/28/22), Gpr119: 1 subμM ligands
    2. G protein-coupled receptor 34a, Zebrafish, B3DHD6 (Curated 03/28/22), gpr34a: 2 subμM ligands
    3. Histone-lysine N-methyltransferase EZH2, Rat, B5DFE2 (Curated 03/29/22), Ezh2: 1 subμM ligands
    4. Hemagglutinin, Influenza A virus (A/reassortant/NIBRG-121(California/07/2009 x PR8)(H1N1)), C5MVR7 (Curated 03/30/22), HA: 3 subμM ligands
    5. G-protein coupled receptor 183, Rat, D4A7K7 (Curated 03/27/22), Gpr183: 3 subμM ligands
    6. Polyamine deacetylase HDAC10, Zebrafish, F1QCV2 (Curated 03/29/22), hdac10: 1 subμM ligands
    7. Dynamin-1-like protein, Human, O00429 (Curated 03/27/22), DNM1L: 2 subμM ligands
    8. Syntenin-1, Human, O00560 (Curated 03/26/22), SDCBP: 7 subμM ligands
    9. Growth hormone secretagogue receptor type 1, Rat, O08725 (Curated 03/24/22), Ghsr: 3 subμM ligands
    10. Long-chain-fatty-acid--AMP ligase FadD32, Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), O53580 (Curated 03/29/22), fadD32: 1 subμM ligands
    11. Formyl peptide receptor 2, Mouse, O88536 (Curated 03/28/22), Fpr2: 5 subμM ligands
    12. Atypical chemokine receptor 3, Rat, O89039 (Curated 03/26/22), Ackr3: 1 subμM ligands
    13. Carbamate kinase, Giardia intestinalis, O97438 (Curated 03/30/22), CBK: 1 subμM ligands
    14. Atypical chemokine receptor 3, Dog, P11613 (Curated 03/26/22), ACKR3: 1 subμM ligands
    15. Cyclic AMP-dependent transcription factor ATF-4, Human, P18848 (Curated 03/27/22), ATF4: 53 subμM ligands
    16. B-cell lymphoma 6 protein, Human, P41182 (Curated 09/20/19), BCL6: 56 subμM ligands
    17. DNA repair protein RAD52 homolog, Human, P43351 (Curated 03/30/22), RAD52: 1 subμM ligands
    18. Protein farnesyltransferase subunit beta, Human, P49356 (Curated 12/14/14), FNTB: 1373 subμM ligands
    19. Signal transducer and activator of transcription 2, Human, P52630 (Curated 03/26/22), STAT2: 1 subμM ligands
    20. Ectonucleoside triphosphate diphosphohydrolase 1, Mouse, P55772 (Curated 03/24/22), Entpd1: 1 subμM ligands
    21. Long-chain-fatty-acid--AMP ligase FadD28, Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), P9WQ59 (Curated 03/29/22), fadD28: 5 subμM ligands
    22. Forkhead box protein M1, Human, Q08050 (Curated 03/28/22), FOXM1: 2 subμM ligands
    23. Adenylate cyclase type 2, Human, Q08462 (Curated 11/10/09), ADCY2: 29 subμM ligands
    24. DNA-binding protein Ikaros, Human, Q13422 (Curated 04/09/22), IKZF1: 4 subμM ligands
    25. Na(+)/H(+) exchange regulatory cofactor NHE-RF2, Human, Q15599 (Curated 03/26/22), SLC9A3R2: 1 subμM ligands
    26. RISC-loading complex subunit TARBP2, Human, Q15633 (Curated 03/24/22), TARBP2: 1 subμM ligands
    27. 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Human, Q16880 (Curated 03/28/22), UGT8: 21 subμM ligands
    28. G protein-coupled receptor 34b, Zebrafish, Q568G5 (Curated 03/28/22), gpr34b: 2 subμM ligands
    29. Potassium channel subfamily T member 1, Human, Q5JUK3 (Curated 03/26/22), KCNT1: 16 subμM ligands
    30. N-terminal Xaa-Pro-Lys N-methyltransferase 2, Human, Q5VVY1 (Curated 03/28/22), NTMT2: 1 subμM ligands
    31. 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Mouse, Q64676 (Curated 03/28/22), Ugt8: 1 subμM ligands
    32. N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, Human, Q6IQ20 (Curated 03/26/22), NAPEPLD: 36 subμM ligands
    33. RNA demethylase ALKBH5, Human, Q6P6C2 (Curated 03/26/22), ALKBH5: 1 subμM ligands
    34. Relaxin receptor 1, Rat, Q6R6I6 (Curated 03/29/22), Rxfp1: 3 subμM ligands
    35. Potassium channel subfamily T member 1, Mouse, Q6ZPR4 (Curated 03/26/22), Kcnt1: 1 subμM ligands
    36. N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, Mouse, Q8BH82 (Curated 03/26/22), Napepld: 4 subμM ligands
    37. Anoctamin-1, Mouse, Q8BHY3 (Curated 03/26/22), Ano1: 2 subμM ligands
    38. Kinesin-like protein KIF18A, Human, Q8NI77 (Curated 03/28/22), KIF18A: 18 subμM ligands
    39. Nuclear receptor subfamily 4 group A member 3, Human, Q92570 (Curated 03/27/22), NR4A3: 2 subμM ligands
    40. Methionine--tRNA ligase, mitochondrial, Human, Q96GW9 (Curated 03/25/22), MARS2: 10 subμM ligands
    41. Neuropeptide FF receptor 1, Rat, Q9EP86 (Curated 03/29/22), Npffr1: 5 subμM ligands
    42. UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Human, Q9H3H5 (Curated 03/25/22), DPAGT1: 3 subμM ligands
    43. Golgi-associated PDZ and coiled-coil motif-containing protein, Human, Q9HD26 (Curated 03/26/22), GOPC: 14 subμM ligands
    44. Short transient receptor potential channel 3, Mouse, Q9QZC1 (Curated 03/26/22), Trpc3: 1 subμM ligands
    45. Potassium channel subfamily T member 1, Rat, Q9Z258 (Curated 03/26/22), Kcnt1: 1 subμM ligands

Coronavirus Binding Data

BindingDB has accelerated collection of COVID related data. You can find the result here.

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BindingDB Data Curation

BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of May 4, 2022, BindingDB's patent dataset comprises:

  1. Patents: 5,660
  2. Binding measurements: 866,553
  3. Compounds: 418,929
  4. Target proteins: 2,293
  5. Assays: 8,204
  6. Average Number of Targets per Patent: 1.92

BindingDB curates a set of journals not covered by other public databases. As of May 4, 2022, the status of this curation effort is as follows:

BindingDB is supported by NIH's National Institute of General Medical Sciences (GM070064), and is located at the Skaggs School of Pharmacy and Pharmaceutical Sciences of the University of California San Diego