PubMed Identification:

Starting with   __   _1   _2   _3   _4   _5   _6   _7   _8   _9   10   11   12   13   14   15   16   17   18   19   20   21   22   23   24   25   26   27   28   29   30   31   32   33   34   35   36   37

PMID
Article Title
Citation
Organization
Download
View Data
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.BDB
Science 382: (2023)
Cornell University
Novel Concept for Super-Soft Topical Drugs: Deactivation by an Enzyme-Induced Switch into an Inactive Conformation.EBI
NA
Novartis Institutes For Biomedical Research
Novel Aryl Hydrocarbon Receptor Agonists for Treating Psoriasis.EBI
NA
Smith, Gambrell & Russell
Covalent EBI
NA
Johannes Gutenberg University Mainz
Design, Synthesis, and Structure-Activity Relationships of Biaryl Anilines as Subtype-Selective PPAR-alpha Agonists.EBI
NA
University of Minnesota
-Aryl Indoles as a Novel Class of Potent NaEBI
NA
Daiichi Sankyo
Discovery of Selective and Potent KRASEBI
NA
Usona Institute
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors.EBI
NA
Jamia Millia Islamia
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2.EBI
NA
Johann Wolfgang Goethe-University
TMPRSS2 Inhibitor Discovery Facilitated through an EBI
NA
University of Michigan
CitA activity is modulated by cysteine oxidation and pyruvate binding.EBI
NA
University of Nebraska
Insights into targeting SARS-CoV-2: design, synthesis, EBI
NA
Egyptian Russian University
Identification of ARUK2002821 as an isoform-selective PI5P4K? inhibitor.EBI
NA
University of Cambridge
Improving binding entropy by higher ligand symmetry? - A case study with human matriptase.EBI
NA
Johannes Gutenberg-University Staudingerweg
Investigating the interactions of flavonoids with human OATP2B1: inhibition assay, ICEBI
NA
Soochow University
Synthesis and structure-activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein.EBI
NA
University of Wollongong
Oxazolidinones as versatile scaffolds in medicinal chemistry.EBI
NA
University College London
Design, synthesis and biological evaluation of novel indole-3-carboxylic acid derivatives with antihypertensive activity.EBI
NA
Lomonosov Moscow State University
Design, synthesis, and pharmacological evaluation of N-(3-carbamoyl-1H-pyrazol-4-yl)-1,3-oxazole-4-carboxamide derivatives as interleukin-1 receptor-associated kinase 4 inhibitors with reduced potential for cytochrome P450 1A2 induction.EBI
NA
Astellas Pharma
Novel AHR Agonists for Treating Psoriasis.EBI
NA
Smith, Gambrell & Russell
Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors.EBI
NA
Northwestern University
Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines.EBI
NA
Tu Dortmund University and Drug Discovery Hub Dortmund (Ddhd) Am Zentrum F£R Integrierte Wirkstoffforschung (Ziw
Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders.EBI
NA
Smith, Gambrell & Russell
1,2,4-Triazine Derivatives as NLRP3 Inhibitors for Treating Diseases.EBI
NA
Smith, Gambrell & Russell
Novel Serine-Arginine Protein Kinase Inhibitors for Treating Cancer.EBI
NA
Smith, Gambrell & Russell
PROTAC: Harnessing Targeted Chimeras for Selective BCL-2 Degradation in Cancer Treatment.EBI
NA
Usona Institute
Synthesis of Veliparib Prodrugs and Determination of Drug-Release-Dependent PARP-1 Inhibition.EBI
NA
University of Pittsburgh
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol.EBI
NA
University of North Carolina at Chapel Hill
Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues.EBI
NA
University of Cambridge
Selective Wee1 Inhibitors Led to Antitumor Activity EBI
NA
Emd Serono
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions.EBI
NA
Smith, Gambrell & Russell
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.EBI
NA
IRBM
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.EBI
NA
Japan Tobacco
Design, synthesis, and anticancer evaluation of arylurea derivatives as potent and selective type II irreversible covalent FGFR4 inhibitors.EBI
NA
China Pharmaceutical University
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.EBI
NA
Infex Therapeutics
Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety.EBI
NA
An Hui University of Traditional Chinese Medicine
Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway.EBI
NA
Korea Institute of Science and Technology
The lipidation and glycosylation enabling bioactivity enhancement and structural change of antibacterial peptide G3.EBI
NA
Fujian Normal University
Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors.EBI
NA
Zhejiang University
Design, synthesis and biological evaluation of novel indole-piperazine derivatives as antibacterial agents.EBI
NA
Northwest A&F University
Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET.EBI
NA
West Virginia University
Design, synthesis, and biological evaluation of acyl sulfonamide derivatives with spiro cycles as NaEBI
NA
Fudan University
Synthesis of novel ciprofloxacin-avibactam conjugates for the development of second-generation non-?-lactam-?-lactamase inhibitors.EBI
NA
CSIR-Institute of Himalayan Bioresource Technology
Discovery of imidazo[1,2-b]pyridazine macrocyclic derivatives as novel ALK inhibitors capable of combating multiple resistant mutants.EBI
NA
Shanghai Institute of Pharmaceutical Industry Co.
Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3K? inhibitors via virtual screening and docking-based structure optimization.EBI
NA
Zhejiang University
Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.EBI
NA
Jouf University Al-Qurayyat
Development of thiazole-appended novel hydrazones as a new class of ?-amylase inhibitors with anticancer assets: an EBI
NA
Ccs Haryana Agricultural University
Ribosome-targeting antibiotics and resistance EBI
NA
Emory University
Computational design of a cyclic peptide that inhibits the CTLA4 immune checkpoint.EBI
NA
Kansas State University
Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity.EBI
NA
Virginia Tech
Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.EBI
NA
Bristol Myers Squibb
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.EBI
NA
Pusan National University
Design, synthesis, and biological evaluation of novel HDAC inhibitors with a 3-(benzazol-2-yl)quinoxaline framework.EBI
NA
Southeast University
Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening.EBI
NA
Queens College of the City University of New York
Identification of small molecule inhibitors against MMP-14 via High-Throughput screening.EBI
NA
University of Illinois at Chicago
Enzymatic transformation of esculetin as a potent class of ?-glucosidase inhibitors.EBI
NA
Korea Atomic Energy Research Institute (KAERI)
Synthesis and evaluation of sulfonamide derivatives targeting EGFREBI
NA
Shenyang Pharmaceutical University
Design, synthesis and bioactivity evaluations of 8-substituted-quinoline-2-carboxamide derivatives as novel histone deacetylase (HDAC) inhibitors.EBI
NA
Shandong University
Targeting the "Undruggable" Driver Protein, KRASEBI
NA
Usona Institute
Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors.EBI
NA
University of Siena
Discovery of EBI
NA
Cerevance
The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders.EBI
NA
Sosei Heptares
Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35.EBI
NA
Dalian Institute of Chemical Physics
Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands.EBI
NA
Hun Biological Research Centre, Szeged
Prenylated Chrysin Derivatives as Partial PPAR? Agonists with Adiponectin Secretion-Inducing Activity.EBI
NA
Seoul National University
Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use.EBI
NA
Taiho Pharmaceutical
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.EBI
NA
University of North Carolina At Chapel Hill
Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry.EBI
NA
University of Gdansk
Accelerating Drug Discovery: Synthesis of Complex Chemotypes via Multicomponent Reactions.EBI
NA
Atavistik Bio
Discovery of Potent Deuterated Compounds as Potential KRASEBI
NA
Usona Institute
Anagrelide: A Clinically Effective cAMP Phosphodiesterase 3A Inhibitor with Molecular Glue Properties.EBI
NA
The Baruch S. Blumberg Institute
Synthesis and biological evaluation of novel pteridin-7(8H)-one derivatives as potent CDK2 inhibitors.EBI
NA
Jiangnan University
Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase.EBI
NA
University of California at San Francisco
3-Arylidene-2-oxindoles as GSK3? inhibitors and anti-thrombotic agents.EBI
NA
Volgograd State Medical University
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.EBI
NA
Bristol Myers Squibb
Hydrazinecarbonyl-thiazol-2-acetamides with pronounced apoptotic behavior: synthesis, in vitro/in vivo anti-proliferative activity and molecular modeling simulations.EBI
NA
Mansoura University
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.EBI
NA
University of Alberta
Siderophores: Chemical tools for precise antibiotic delivery.EBI
NA
Universidade De Santiago De Compostela
Identification of a Noxo1 inhibitor by addition of a polyethylene glycol chain.EBI
NA
University of Cincinnati
Bacterial GTPases as druggable targets to tackle antimicrobial resistance.EBI
NA
Indian Institute of Science Education and Research Bhopal
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.EBI
NA
Bristol Myers Squibb
Discovery of FXR/PPAR? dual partial agonist.EBI
NA
Hiroshima International University
An ATG4B inhibitor blocks autophagy and sensitizes Sorafenib inhibition activities in HCC tumor cells.EBI
NA
Yantai University
Design, synthesis and biological evaluation of quinazoline SOS1 inhibitors.EBI
NA
Jiangnan University
Design, synthesis and bioactivity evaluation of a series of quinazolinone derivatives as potent PI3K? antagonist.EBI
NA
Southern Medical University
Palbociclib and Michael-acceptor hybrid compounds as CDK4/6 covalent inhibitors: Improved potency, broad anticancer spectrum and overcoming drug resistance.EBI
NA
Southeast University
Development of [EBI
NA
Chongqing Medical University
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HTEBI
NA
University of Sassari
Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist.EBI
NA
Byondis
Total Synthesis and Biological Evaluation of the Anti-Inflammatory (13EBI
NA
Johannes Gutenberg-University

BDB Curated by BindingDB
EBI Curated by ChEMBL