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In silico evaluation of human small heat shock protein HSP27: homology modeling, mutation analyses and docking studies.
Bioorg Med Chem 23: 3215-20 (2015)
Universit£
Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.
Bioorg Med Chem 23: 3208-14 (2015)
Universit£
Activity and anion inhibition studies of thea-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.
Bioorg Med Chem Lett 25: 4937-40 (2015)
University Of Florida
Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking.
Bioorg Med Chem Lett 25: 2713-9 (2015)
Acelot
Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptorß-selective agonists.
Bioorg Med Chem Lett 25: 2668-74 (2015)
Kowa
Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B.
Chem Biol Drug Des 86: 1161-7 (2015)
Jiangnan University
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities atµ (MOR),d (DOR), and¿ (KOR) Opioid Receptors.
J Med Chem 58: 4905-17 (2015)
Torrey Pines Institute For Molecular Studies
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Inhibitors and Structure-Activity Relationships.
J Nat Prod 78: 1262-70 (2015)
Albert-Ludwigs-University Of Freiburg
Functional Profiling of 2-Aminopyrimidine Histamine H4 Receptor Modulators.
J Med Chem 58: 7119-27 (2015)
Janssen Research And Development
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.
J Med Chem 58: 4550-72 (2015)
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University)
Synthesis and Biological Evaluation of Novel Olean-28,13ß-lactams as Potential Antiprostate Cancer Agents.
J Med Chem 58: 4506-20 (2015)
China Pharmaceutical University
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
J Med Chem 58: 7634-58 (2015)
University Of Bath
Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
Bioorg Med Chem Lett 25: 2613-6 (2015)
University Of Kentucky
Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin.
J Med Chem 58: 4839-44 (2015)
Institute For Infection Research
Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.
J Med Chem 58: 5053-74 (2015)
Argenta Discovery
Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).
Bioorg Med Chem Lett 25: 2702-6 (2015)
Kyoto Pharmaceutical University
Discovery of a novel Kv7 channel opener as a treatment for epilepsy.
Bioorg Med Chem Lett 25: 4941-4 (2015)
Pfizer
9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.
Bioorg Med Chem Lett 25: 2809-12 (2015)
Bristol-Myers Squibb
Discovery of Selective Small-Molecule Inhibitors for theß-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.
J Med Chem 58: 4678-92 (2015)
University Of Utah
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
J Med Chem 58: 4529-49 (2015)
The Hong Kong Polytechnic University
Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.
Eur J Med Chem 97: 245-58 (2015)
Korea Institute Of Science And Technology
Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutantß-N-acetylhexosaminidase Activity.
J Med Chem 58: 4483-93 (2015)
Sickkids
De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one¿-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo.
J Med Chem 58: 4624-37 (2015)
Universit£
Exploring S1 plasticity and probing S1' subsite of mammalian aminopeptidase N/CD13 with highly potent and selective aminobenzosuberone inhibitors.
Bioorg Med Chem 23: 3192-207 (2015)
Universit£
Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor¿/d agonists.
Bioorg Med Chem 23: 3322-36 (2015)
Sookmyung Women'S University
Discovery of biphenyl-aryl ureas as novel VEGFR-2 inhibitors. Part 4: exploration of diverse hinge-binding fragments.
Bioorg Med Chem 23: 3228-36 (2015)
Xi'An Jiaotong University
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.
Bioorg Med Chem 23: 3269-77 (2015)
Astellas Pharma
2-Aminoalkyl nicotinamide derivatives as pure inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett 25: 2707-12 (2015)
Asubio Pharma
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Bioorg Med Chem Lett 25: 2488-92 (2015)
Merck Research Laboratories
Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.
Bioorg Med Chem Lett 25: 2654-6 (2015)
Martin-Luther-Universit£T Halle-Wittenberg
Design of selective PI3Ka inhibitors starting from a promiscuous pan kinase scaffold.
Bioorg Med Chem Lett 25: 2679-85 (2015)
Astrazeneca
Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.
Bioorg Med Chem Lett 25: 2469-72 (2015)
Chinese Academy Of Sciences
Development of a novel class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett 25: 4945-9 (2015)
Merck Research Laboratories
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).
Bioorg Med Chem Lett 25: 2496-500 (2015)
Astrazeneca
Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Bioorg Med Chem Lett 25: 2473-8 (2015)
Merck Research Laboratories
Separation and peroxisome proliferator-activated receptor-¿ agonist activity evaluation of synthetic racemic bavachinin enantiomers.
Bioorg Med Chem Lett 25: 2579-83 (2015)
Shanghai University Of Traditional Chinese Medicine
Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp.
J Nat Prod 78: 1221-30 (2015)
Jinan University
Synthesis and Biological Evaluation of Cyclopentaquinoline Derivatives as Nonsteroidal Glucocorticoid Receptor Antagonists.
J Med Chem 58: 4918-26 (2015)
TBA
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2.
J Med Chem 58: 4790-801 (2015)
TBA
Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3.
Bioorg Med Chem 23: 3414-25 (2015)
Fcfrp - Usp
Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.
Bioorg Med Chem 23: 2767-80 (2015)
Technische Universit£T Dortmund
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
Bioorg Med Chem 23: 3248-59 (2015)
Beni-Suef University
Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.
J Med Chem 58: 4812-21 (2015)
University Of California
Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction.
J Med Chem 58: 4449-61 (2015)
Bogomoletz Institute Of Physiology Of Nas Ukraine
Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.
J Med Chem 59: 1642-7 (2016)
University Of Oxford
Progress in discovery of small-molecule modulators of protein-protein interactions via fragment screening.
Bioorg Med Chem Lett 25: 2461-8 (2015)
Pfizer
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.
Bioorg Med Chem Lett 25: 2514-8 (2015)
Methylgene
Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.
J Med Chem 58: 9421-37 (2015)
Sib Swiss Institute Of Bioinformatics
Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs.
J Med Chem 58: 4693-702 (2015)
The University Of Wollongong And The Illawarra Health And Medical Research Institute
Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174.
J Med Chem 58: 4204-19 (2015)
The University Of Tokyo
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.
Eur J Med Chem 97: 181-9 (2015)
Tehran University Of Medicinal Sciences
A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.
Eur J Med Chem 97: 173-80 (2015)
University Of Barcelona
Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers.
Bioorg Chem 60: 64-73 (2015)
Panjab University
New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
J Med Chem 58: 4738-48 (2015)
Stony Brook University
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
J Med Chem 58: 4165-79 (2015)
Eli Lilly
Novel myricetin derivatives: Design, synthesis and anticancer activity.
Eur J Med Chem 97: 155-63 (2015)
Guizhou University
Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.
Eur J Med Chem 97: 142-54 (2015)
Jagiellonian University Medical College
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.
J Med Chem 58: 4610-23 (2015)
"Sapienza" Universit£
Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J Med Chem 58: 4727-37 (2015)
Eli Lilly
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.
Bioorg Med Chem Lett 25: 2523-6 (2015)
Univ. Rouen
Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Bioorg Med Chem Lett 25: 2594-8 (2015)
Marquette University
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Eur J Med Chem 97: 104-23 (2015)
Guru Nanak Dev University
Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives.
Bioorg Chem 60: 49-57 (2015)
Ataturk University
Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen.
Bioorg Med Chem Lett 25: 2536-9 (2015)
Washington State University
Isatin based Schiff bases as inhibitors of a-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies.
Bioorg Chem 60: 42-8 (2015)
Hazara University
Discovery, bioactivity and docking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors and antitumor agents.
Bioorg Med Chem 23: 3457-71 (2015)
Southeast University
Discovery of (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist.
J Med Chem 58: 4648-64 (2015)
Eisai
Design and synthesis of close analogs of LCRF-0004, a potent and selective RON receptor tyrosine kinase inhibitor.
Bioorg Med Chem Lett 25: 2527-31 (2015)
Chemrf Laboratories
Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.
Chem Biol Drug Des 86: 1115-20 (2015)
University Of Karachi
Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids.
Eur J Med Chem 97: 94-103 (2015)
Medical University
Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.
J Med Chem 58: 4266-77 (2015)
Institute Of Pharmaceutical Sciences
Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIa Catalytic Inhibitors.
ACS Med Chem Lett 6: 481-5 (2015)
Department Of Pharmaceutical Technology (Biotechnology), Department Of Pharmacoinformatics, And Department Of Medicinal Chemistry, National Institute Of Pharmaceutical Education And Research (Niper
Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors.
ACS Med Chem Lett 6: 472-5 (2015)
University Of Copenhagen
Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.
ACS Med Chem Lett 6: 461-5 (2015)
Merck Research Laboratories
Rho kinase inhibitors: potentially versatile therapy for the treatment of cardiovascular diseases and more.
ACS Med Chem Lett 6: 371-2 (2015)
Therachem Research Medilab (India)
Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors.
ACS Med Chem Lett 6: 359-62 (2015)
Roche Innovation Center Shanghai
4,6-Diarylaminothiazines as BACE1 Inhibitors and Their Use for the Reduction of Beta-Amyloid Production.
ACS Med Chem Lett 6: 237-8 (2015)
Temple University School Of Pharmacy
Biphenyl-ethyl-pyrrolidine derivatives as histamine h3 receptor modulators for the treatment of cognitive disorders.
ACS Med Chem Lett 6: 235-6 (2015)
Temple University School Of Pharmacy
Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Chem Biol Drug Des 86: 1168-77 (2015)
Sichuan University
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.
Eur J Med Chem 97: 42-54 (2015)
University Of Campinas
Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ.
Eur J Med Chem 97: 32-41 (2015)
Shandong University
Amorfrutins Are Natural PPAR¿ Agonists with Potent Anti-inflammatory Properties.
J Nat Prod 78: 1160-4 (2015)
Max Planck Institute For Molecular Genetics
The chemistry and pharmacology of privileged pyrroloquinazolines.
Medchemcomm 6: 510-520 (2015)
Oregon Health & Science University
a-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett 25: 2326-30 (2015)
Seoul National University
Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.
Bioorg Med Chem Lett 25: 2275-9 (2015)
University Of Maryland
Rapid development of two factor IXa inhibitors from hit to lead.
Bioorg Med Chem Lett 25: 2321-5 (2015)
Merck Research Laboratories
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
Bioorg Med Chem Lett 25: 2261-8 (2015)
University Of Illinois At Chicago
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors.
Bioorg Med Chem 23: 3426-35 (2015)
University Of Genoa
Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.
Bioorg Med Chem 23: 3436-47 (2015)
Jagiellonian University Medical College
Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.
Bioorg Med Chem Lett 25: 2269-74 (2015)
Chungbuk National University
N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation.
Bioorg Med Chem Lett 25: 2331-4 (2015)
University Of Iowa
Discovery of novel N-aryl piperazine CXCR4 antagonists.
Bioorg Med Chem Lett 25: 4950-5 (2015)
Emory Institute For Drug Development
Structure-activity relationships of the prototypical TRPM8 agonist icilin.
Bioorg Med Chem Lett 25: 2285-90 (2015)
National Research Council
New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.
Eur J Med Chem 97: 10-8 (2015)
University Of Pisa
Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Eur J Med Chem 97: 1-9 (2015)
Fudan University
Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.
Bioorg Med Chem 23: 3722-9 (2015)
Sun Yat-Sen University
Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.
Bioorg Med Chem 23: 3490-8 (2015)
Goethe-University Frankfurt
Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors.
Bioorg Med Chem 23: 3472-80 (2015)
Srinakharinwirot University
Boronic acid-containing CXCR1/2 antagonists: Optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model.
Bioorg Med Chem Lett 25: 2280-4 (2015)
Syntrix Biosystems
Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.
Biochemistry 54: 3197-206 (2015)
University Of Kentucky
Flavonoids from Matteuccia struthiopteris and Their Anti-influenza Virus (H1N1) Activity.
J Nat Prod 78: 987-95 (2015)
Shenyang Pharmaceutical University
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
J Med Chem 58: 7093-118 (2015)
Merck Research Laboratories
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.
J Med Chem 58: 4590-609 (2015)
Universit£
Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
J Med Chem 58: 4357-63 (2015)
Academy Of Sciences Of The Czech Republic
Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis.
J Nat Prod 78: 1179-83 (2015)
Riken Center For Sustainable Resource Science
Synthesis and evaluation of quinazoline amino acid derivatives as mono amine oxidase (MAO) inhibitors.
Bioorg Med Chem 23: 3574-85 (2015)
Alexandria University
Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1.
Bioorg Med Chem 23: 3681-6 (2015)
University Of Arkansas For Medical Sciences
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.
Bioorg Med Chem 23: 3526-33 (2015)
Csir-Indian Institute Of Chemical Technology
Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.
Bioorg Med Chem 23: 3592-602 (2015)
Agriibrahim£E£En University
New matrix metalloproteinase inhibitors based on¿-fluorinateda-aminocarboxylic anda-aminohydroxamic acids.
Bioorg Med Chem 23: 3809-18 (2015)
Westf£Lische Wilhelms-Universit£T M£Nster
New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.
Bioorg Med Chem 23: 3674-80 (2015)
Siedlce University Of Natural Sciences And Humanities
Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine.
Bioorg Med Chem 23: 3696-704 (2015)
Hiroshima International University
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Bioorg Med Chem 23: 2786-97 (2015)
Sanford-Burnham Medical Research Institute
Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives.
Bioorg Chem 60: 37-41 (2015)
Comsats Institute Of Information Technology
Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors.
Chem Biol Drug Des 86: 1087-92 (2015)
Hunan University Of Science And Technology
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
J Med Chem 58: 4822-38 (2015)
The University Of Queensland
Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases.
Biochemistry 54: 3183-96 (2015)
Louis Stokes Cleveland Veterans Affairs Medical Center
New Frontiers in Selective Human MAO-B Inhibitors.
J Med Chem 58: 6717-32 (2015)
Sapienza University Of Rome
Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.
J Med Chem 58: 6733-46 (2015)
Genentech
Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.
Medchemcomm 6: 444-454 (2015)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Synthesis and antibacterial activities of cadiolides A, B and C and analogues.
Bioorg Med Chem 23: 3618-28 (2015)
Normandie Univ
Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIa inhibitory activity.
Bioorg Med Chem Lett 25: 2405-8 (2015)
Russian Academy Of Science
Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII.
Bioorg Med Chem Lett 25: 2377-81 (2015)
Harran University
Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.
Eur J Med Chem 96: 425-35 (2015)
Cairo University
Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors.
Eur J Med Chem 96: 405-24 (2015)
The State University Of New York
Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo.
Eur J Med Chem 96: 382-95 (2015)
Xi'An Jiaotong University
Design, synthesis and structure-activity relationship of oxazolidinone derivatives containing novel S4 ligand as FXa inhibitors.
Eur J Med Chem 96: 369-80 (2015)
Shenyang Pharmaceutical University
Current kinase inhibitors cover a tiny fraction of fragment space.
Bioorg Med Chem Lett 25: 2372-6 (2015)
University Of Zurich
Structure activity relationship of substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-4).
Bioorg Med Chem Lett 25: 2409-15 (2015)
Merck Research Laboratories
1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor¿ and promote the browning of white adipose.
Bioorg Med Chem 23: 3751-60 (2015)
Guangzhou Institutes Of Biomedicine And Health
Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore.
J Med Chem 58: 3997-4015 (2015)
Purdue University
Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9.
Bioorg Med Chem Lett 25: 2447-51 (2015)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Design, synthesis and biological evaluation of deuterated Tivozanib for improving pharmacokinetic properties.
Bioorg Med Chem Lett 25: 2425-8 (2015)
Sichuan University
Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.
Bioorg Med Chem 23: 3860-8 (2015)
Fudan University
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects.
Bioorg Med Chem 23: 3730-7 (2015)
Catholic University Of Daegu
Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.
Bioorg Med Chem 23: 2839-47 (2015)
Freie Universit£T Berlin
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
Bioorg Med Chem 23: 2798-809 (2015)
Indiana University
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
J Med Chem 58: 4573-80 (2015)
University Of Helsinki
Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.
J Med Chem 58: 4325-38 (2015)
Shandong University
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.
J Med Chem 58: 4073-9 (2015)
Istituto Ortopedico Rizzoli (Ior)
Rational design of dual peptides targeting ghrelin and Y2 receptors to regulate food intake and body weight.
J Med Chem 58: 4180-93 (2015)
Universit£T Leipzig
9-Hydroxycanthin-6-one, aß-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3ß without Depending on Casein Kinase 1a.
J Nat Prod 78: 1139-46 (2015)
Chiba University
Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of thed-opioid receptor.
J Med Chem 58: 4220-9 (2015)
Bristol-Myers Squibb
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
J Med Chem 58: 3922-43 (2015)
Sloan-Kettering Institute For Cancer Research
Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Bioorg Med Chem Lett 25: 2100-5 (2015)
Marquette University
Discovery of novel tricyclic pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amine derivatives as VEGFR-2 inhibitors.
Bioorg Chem 60: 1-12 (2015)
Suez Canal University
Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.
Eur J Med Chem 96: 340-59 (2015)
Georgia Institute Of Technology
New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.
Eur J Med Chem 96: 318-29 (2015)
Universitat De Barcelona
Synthesis and identification of unprecedented selective inhibitors of CK1e.
Eur J Med Chem 96: 308-17 (2015)
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
Design, synthesis and biological evaluation of pyridazino[3,4,5-de]quinazolin-3(2H)-one as a new class of PARP-1 inhibitors.
Bioorg Med Chem Lett 25: 2340-4 (2015)
Peking University
Discovery of aß-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.
J Med Chem 58: 4638-47 (2015)
University Of Minnesota
C7ß-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero, efficacy at mu opioid receptors.
J Med Chem 58: 4242-9 (2015)
University Of Bath
Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.
J Med Chem 58: 4309-24 (2015)
Agoralaan Abis
Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.
J Med Chem 58: 3892-909 (2015)
Takeda Pharmaceutical
Highly Selective Phosphatidylinositol 4-Kinase IIIß Inhibitors and Structural Insight into Their Mode of Action.
J Med Chem 58: 3767-93 (2015)
Gilead Sciences
Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation.
J Nat Prod 78: 971-6 (2015)
Chungbuk National University
Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum.
J Nat Prod 78: 1073-82 (2015)
Medical University Of Vienna
Re(I) and Tc(I) complexes for targeting nitric oxide synthase: influence of the chelator in the affinity for the enzyme.
Chem Biol Drug Des 86: 1072-86 (2015)
Universidade De Lisboa
Azolylthioacetamide: A Highly Promising Scaffold for the Development of Metallo-ß-lactamase Inhibitors.
ACS Med Chem Lett 6: 455-60 (2015)
North-West University
Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.
ACS Med Chem Lett 6: 450-4 (2015)
Janssen Pharmaceutical Companies Of Johnson & Johnson
Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.
ACS Med Chem Lett 6: 439-44 (2015)
Bristol-Myers Squibb
Discovery of a Novel Series of Thienopyrimidine as Highly Potent and Selective PI3K Inhibitors.
ACS Med Chem Lett 6: 434-8 (2015)
Pkucare Pharmaceutical R & D Center
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.
ACS Med Chem Lett 6: 419-24 (2015)
Pfizer
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
ACS Med Chem Lett 6: 413-8 (2015)
Translational Research Institute
Discovery of a Dual PRMT5-PRMT7 Inhibitor.
ACS Med Chem Lett 6: 408-12 (2015)
University Of Toronto
Peptidic inhibitors for in vitro pentamer formation of human papillomavirus capsid protein l1.
ACS Med Chem Lett 6: 381-5 (2015)
Jilin University
Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents.
Bioorg Med Chem Lett 25: 2133-40 (2015)
Georgia State University
PTP1B inhibitors from stems of Angelica keiskei (Ashitaba).
Bioorg Med Chem Lett 25: 2028-32 (2015)
Chinese Academy Of Sciences
Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists.
Bioorg Med Chem Lett 25: 2041-5 (2015)
Astrazeneca
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.
Bioorg Med Chem 23: 3796-808 (2015)
University Of Auckland
Thiazolidine-2,4-dione derivatives: programmed chemical weapons for key protein targets of various pathological conditions.
Bioorg Med Chem 23: 2953-74 (2015)
Punjabi University
A FRET-based assay for screening SIRT6 modulators.
Eur J Med Chem 96: 245-9 (2015)
Guiyang Medical University
Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor.
Bioorg Med Chem 23: 2360-7 (2015)
Daiichi Sankyo
Synthesis and evaluation of novel amide amino-ß-lactam derivatives as cholesterol absorption inhibitors.
Bioorg Med Chem 23: 2353-9 (2015)
Ruder Boskovic Institute
Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one.
Bioorg Med Chem 23: 2489-97 (2015)
Nas Of Ukraine
Structure activity relationship of selective GABA uptake inhibitors.
Bioorg Med Chem 23: 2480-8 (2015)
University Of Copenhagen
Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders.
Bioorg Med Chem 23: 2387-407 (2015)
Nerviano Medical Sciences
Theß-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.
Bioorg Med Chem 23: 2303-9 (2015)
University Of Tampere And Tampere University Hospital
Non-peptide ligand binding to the formyl peptide receptor FPR2--A comparison to peptide ligand binding modes.
Bioorg Med Chem 23: 4072-81 (2015)
University Of Warsaw
Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations.
Bioorg Med Chem 23: 2505-17 (2015)
Shanghai Institute Of Technology
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Bioorg Med Chem 23: 2328-43 (2015)
Washington University
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Bioorg Med Chem 23: 2408-23 (2015)
Duquesne University
The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.
Bioorg Med Chem Lett 25: 2060-4 (2015)
Rti International
Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition.
Bioorg Med Chem Lett 25: 2146-51 (2015)
National Cancer Institute-Frederick
Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.
Bioorg Med Chem Lett 25: 2429-33 (2015)
Sichuan University
Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors.
Bioorg Med Chem Lett 25: 2169-73 (2015)
Bristol-Myers Squibb R & D
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
J Med Chem 58: 4888-904 (2015)
Seragon Pharmaceuticals
6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.
J Med Chem 58: 3975-83 (2015)
Latvian Institute Of Organic Synthesis
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
Eur J Med Chem 96: 162-72 (2015)
University Of Catania
Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11ß-Hydroxylase.
Eur J Med Chem 96: 139-50 (2015)
Saarland University
Design, synthesis and structural exploration of novel fluorinated dabigatran derivatives as direct thrombin inhibitors.
Eur J Med Chem 96: 122-38 (2015)
Shanghai Institute Of Technology
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.
Eur J Med Chem 96: 105-21 (2015)
Universita' Di Firenze
Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa.
Eur J Med Chem 96: 14-21 (2015)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors.
Eur J Med Chem 96: 1-13 (2015)
Southeast University
Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.
Bioorg Med Chem Lett 25: 2211-6 (2015)
Chinese Academy Of Sciences
Application of cultured human mast cells (CHMC) for the design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.
Bioorg Med Chem Lett 25: 2117-21 (2015)
Amarit Bioscience
TR-FRET binding assay targeting unactivated form of Bruton's tyrosine kinase.
Bioorg Med Chem Lett 25: 2033-6 (2015)
Carna Biosciences
Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1.
Chem Biol Drug Des 86: 1049-54 (2015)
Depaul University
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.
J Nat Prod 78: 885-95 (2015)
Chinese Academy Of Sciences
Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4.
Bioorg Med Chem Lett 25: 1836-41 (2015)
Merck Research Laboratories
Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.
Bioorg Med Chem 23: 4056-64 (2015)
National Institute Of Diabetes And Digestive And Kidney Diseases
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Bioorg Med Chem 23: 2424-34 (2015)
Merck Research Laboratories
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Bioorg Med Chem 23: 2518-28 (2015)
Hacettepe University
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors withß-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Bioorg Med Chem 23: 2445-57 (2015)
Jagiellonian University
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Bioorg Med Chem 23: 2548-61 (2015)
Jagiellonian University Medical College
2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy.
Bioorg Med Chem Lett 25: 1910-4 (2015)
Kaken Pharmaceutical
Fingerprint-based consensus virtual screening towards structurally new 5-HT(6)R ligands.
Bioorg Med Chem Lett 25: 1827-30 (2015)
Jagiellonian University
Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors.
Bioorg Med Chem Lett 25: 1947-51 (2015)
The First Affiliated Hospital Of Nanjing Medical University
Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies.
Bioorg Med Chem 23: 2435-44 (2015)
Forman Christian College (A Chartered University)
Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity.
Bioorg Med Chem 23: 2562-7 (2015)
Hebei University Of Science & Technology
Exploration of benzamidochromenone derivatives with conformational restrictor as interleukin-5 inhibitors.
Bioorg Med Chem 23: 2498-504 (2015)
Chungnam National University
Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases.
Chembiochem 16: 1350-6 (2015)
University Of Toronto
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.
Angew Chem Int Ed Engl 54: 6217-21 (2015)
University Of Oxford
N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II.
Bioorg Med Chem 23: 2598-605 (2015)
Atat£Rk University
Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening.
Bioorg Med Chem 23: 2310-7 (2015)
Astellas Pharma
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.
Bioorg Med Chem 23: 2568-78 (2015)
Takeda Pharmaceutical
Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.
Bioorg Med Chem Lett 25: 4956-60 (2015)
Virginia Tech
Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.
Bioorg Med Chem Lett 25: 1849-55 (2015)
Mayo Clinic
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase.
Bioorg Med Chem Lett 25: 1896-900 (2015)
North-West University
BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.
Bioorg Med Chem Lett 25: 1905-9 (2015)
Bristol-Myers Squibb Research And Development
Activation of the¿-Aminobutyric Acid Type B (GABA(B)) Receptor by Agonists and Positive Allosteric Modulators.
J Med Chem 58: 6336-47 (2015)
Purdue University
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
J Med Chem 59: 1425-39 (2016)
Glaxosmithkline R&D
HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).
J Med Chem 58: 3910-21 (2015)
University Of Bonn
Synthesis of 5,6-dihydro-4H-benzo[d]isoxazol-7-one and 5,6-dihydro-4H-isoxazolo[5,4-c]pyridin-7-one derivatives as potential Hsp90 inhibitors.
Chem Biol Drug Des 86: 1030-5 (2015)
University Of Milano
Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Bioorg Med Chem Lett 25: 1831-5 (2015)
Merck Research Laboratories
Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).
J Med Chem 58: 3859-74 (2015)
TBA
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.
J Med Chem 58: 3611-25 (2015)
Astrazeneca
Towards small molecule inhibitors of mono-ADP-ribosyltransferases.
Eur J Med Chem 95: 546-51 (2015)
Karolinska Institutet
Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.
Eur J Med Chem 95: 526-45 (2015)
Siena Biotech
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.
Bioorg Med Chem 23: 2368-76 (2015)
Universit£
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Bioorg Med Chem Lett 25: 1856-63 (2015)
Bristol-Myers Squibb Research And Development
Inactivation of Mandelate Racemase by 3-Hydroxypyruvate Reveals a Potential Mechanistic Link between Enzyme Superfamilies.
Biochemistry 54: 2747-57 (2015)
Dalhousie University
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.
J Med Chem 58: 3794-805 (2015)
Vanderbilt University School Of Medicine
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.
J Med Chem 58: 3806-16 (2015)
Genentech
Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.
Bioorg Med Chem 23: 1963-74 (2015)
Fudan University
Discovery of N-benzoxazol-5-yl-pyrazole-4-carboxamides as nanomolar SQR inhibitors.
Eur J Med Chem 95: 424-34 (2015)
Central China Normal University
Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators.
Bioorg Med Chem Lett 25: 1892-5 (2015)
Boehringer Ingelheim Pharmaceuticals
Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents.
Bioorg Med Chem 23: 2221-40 (2015)
University Of Toronto
Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation.
Eur J Med Chem 95: 388-99 (2015)
China Pharmaceutical University
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
J Med Chem 58: 4080-5 (2015)
University Of Queensland
Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.
Bioorg Med Chem Lett 25: 1884-91 (2015)
Actelion Pharmaceuticals
Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors.
Bioorg Med Chem Lett 25: 1872-5 (2015)
Southern Medical University
Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands.
Bioorg Med Chem Lett 25: 1880-3 (2015)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-a agonistic activity.
Bioorg Med Chem Lett 25: 1998-2001 (2015)
Aichi Gakuin University
Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.
J Nat Prod 78: 803-10 (2015)
Chungnam National University
Novel arylazopyrazole inhibitors of cyclin-dependent kinases.
Bioorg Med Chem 23: 1975-81 (2015)
Palack�
Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer.
J Med Chem 58: 3957-74 (2015)
Sichuan University
Allotides: Proline-Rich Cystine Knota-Amylase Inhibitors from Allamanda cathartica.
J Nat Prod 78: 695-704 (2015)
Nanyang Technological University
Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.
J Med Chem 58: 3548-71 (2015)
Glaxosmithkline
Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.
Eur J Med Chem 94: 447-57 (2015)
Nanjing University
Histone H3 peptide based LSD1-selective inhibitors.
Bioorg Med Chem Lett 25: 1925-8 (2015)
Waseda University
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Bioorg Med Chem Lett 25: 1990-4 (2015)
Vertex Pharmaceuticals
3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.
Eur J Med Chem 95: 349-56 (2015)
Teva Global R & D.
Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis.
Eur J Med Chem 95: 302-12 (2015)
Chinese Academy Of Sciences
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities ata7 nAChRs through incorporation of known structural motifs.
Eur J Med Chem 95: 277-301 (2015)
The University Of Sydney
Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.
J Med Chem 58: 5361-80 (2015)
National Institute On Drug Abuse-Intramural Research Program
Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
J Med Chem 58: 3393-410 (2015)
Ku Leuven
DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting.
J Med Chem 58: 3094-103 (2015)
Purdue University
Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.
Bioorg Med Chem 23: 2044-52 (2015)
Siberian Branch Of The Russian Academy Of Sciences
Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors.
Bioorg Med Chem Lett 25: 1979-81 (2015)
Toho University
Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium.
Bioorg Med Chem Lett 25: 1986-9 (2015)
Hunan University Of Chinese Medicine
Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors.
Bioorg Med Chem 23: 1994-2003 (2015)
Shandong University
The CERT antagonist HPA-12: first practical synthesis and individual binding evaluation of the four stereoisomers.
Bioorg Med Chem 23: 2004-9 (2015)
Universit£
A FRET-based assay for screening SIRT5 specific modulators.
Bioorg Med Chem Lett 25: 1671-4 (2015)
Guiyang Medical University
Synthesis of diethyl 4-substituted-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates as a new series of inhibitors against yeasta-glucosidase.
Eur J Med Chem 95: 199-209 (2015)
University Of Karachi
Design, synthesis and biological evaluation of N-phenylthieno[2,3-d]pyrimidin-4-amines as inhibitors of FGFR1.
Bioorg Med Chem 23: 2287-93 (2015)
Institute Of Molecular Biology And Genetics Nas Of Ukraine
Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.
ACS Med Chem Lett 6: 349-54 (2015)
University Of Illinois At Urbana-Champaign
Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.
ACS Med Chem Lett 6: 339-43 (2015)
The Scripps Research Institute
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists.
ACS Med Chem Lett 6: 334-8 (2015)
Okayama University Graduate School Of Medicine
Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.
ACS Med Chem Lett 6: 329-33 (2015)
University Of Cambridge
Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.
ACS Med Chem Lett 6: 324-8 (2015)
University Park Nottingham
Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
ACS Med Chem Lett 6: 318-23 (2015)
Merck Research Laboratories
Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ.
ACS Med Chem Lett 6: 308-12 (2015)
University Of California Davis
Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites.
ACS Med Chem Lett 6: 302-7 (2015)
Tokyo University Of Pharmacy And Life Sciences
Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM.
ACS Med Chem Lett 6: 296-301 (2015)
Yuhan Research Institute
a-Carbonic Anhydrases Possess Thioesterase Activity.
ACS Med Chem Lett 6: 292-5 (2015)
Universit£
Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors.
ACS Med Chem Lett 6: 282-6 (2015)
Janssen Pharmaceutica
Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.
ACS Med Chem Lett 6: 266-70 (2015)
Daiichi Sankyo
Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors.
ACS Med Chem Lett 6: 244-8 (2015)
Kissei Pharmaceutical
Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.
ACS Med Chem Lett 6: 239-43 (2015)
Fujian University Of Traditional Chinese Medicine
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
ACS Med Chem Lett 6: 276-81 (2015)
Genentech
a-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
Bioorg Med Chem 23: 2104-11 (2015)
Jagiellonian University Medical College
New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
Bioorg Med Chem Lett 25: 1665-70 (2015)
University Of Monastir
Small cyclic agonists of iron regulatory hormone hepcidin.
Bioorg Med Chem Lett 25: 4961-9 (2015)
University Of California Los Angeles
Synthesis and biological evaluation of 2,4-diaminopyrimidines as selective Aurora A kinase inhibitors.
Eur J Med Chem 95: 174-84 (2015)
Lanzhou University
Design and synthesis of celastrol derivatives as anticancer agents.
Eur J Med Chem 95: 166-73 (2015)
Anhui Medical University
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Eur J Med Chem 95: 153-65 (2015)
China Pharmaceutical University
Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines.
Biochemistry 54: 2530-8 (2015)
Northwestern University
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.
J Med Chem 58: 3512-21 (2015)
Yonsei University
Rational design of triazololipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins.
J Med Chem 58: 3459-70 (2015)
Umr7247
Synthesis and biological evaluation of nitrated 7-, 8-, 9-, and 10-hydroxyindenoisoquinolines as potential dual topoisomerase I (Top1)-tyrosyl-DNA phosphodiesterase I (TDP1) inhibitors.
J Med Chem 58: 3188-208 (2015)
Purdue University
Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.
J Nat Prod 78: 896-900 (2015)
National Cancer Institute-Bethesda
Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
Eur J Med Chem 95: 127-35 (2015)
East China Normal University
Discovery of Potent Inhibitors of Schistosoma mansoni NAD¿ Catabolizing Enzyme.
J Med Chem 58: 3582-92 (2015)
University Of Strasburg
Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter.
Bioorg Med Chem Lett 25: 1757-60 (2015)
Vanderbilt University Medical Center
Pseudosaccharin amines as potent and selective KV1.5 blockers.
Bioorg Med Chem Lett 25: 4983-6 (2015)
Bristol-Myers Squibb Research And Development
Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5.
Bioorg Med Chem 23: 2121-8 (2015)
Csir-Indian Institute Of Integrative Medicine
Acyl-2-aminobenzimidazoles: a novel class of neuroprotective agents targeting mGluR5.
Bioorg Med Chem 23: 2211-20 (2015)
University Of Maryland
Design and synthesis of novel quinoline-aminopiperidine hybrid analogues as Mycobacterium tuberculosis DNA gyraseB inhibitors.
Bioorg Med Chem 23: 2062-78 (2015)
Birla Institute Of Technology
Cell-based biological evaluations of 5-(3-bromo-4-phenethoxybenzylidene)thiazolidine-2,4-dione as promising wound healing agent.
Bioorg Med Chem 23: 2098-103 (2015)
Chosun University
Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation.
Eur J Med Chem 95: 116-26 (2015)
University Of South Australia
Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.
Eur J Med Chem 95: 104-15 (2015)
Central South University
Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid.
Bioorg Med Chem 23: 2079-97 (2015)
Ono Pharmaceutical
Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase.
Bioorg Chem 59: 140-4 (2015)
University Of Strasburg
Synthesis and optimization of picolinamide derivatives as a novel class of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.
Bioorg Med Chem Lett 25: 1679-83 (2015)
Seoul National University
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Bioorg Med Chem Lett 25: 1736-41 (2015)
RhôNe-Poulenc Rorer
Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett 25: 1705-8 (2015)
Sumitomo Dainippon Pharma
Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.
Eur J Med Chem 103: 615-27 (2015)
Taipei Medical University
Design and Synthesis of Newa-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression.
J Med Chem 58: 3534-47 (2015)
Shanghai Jiao Tong University
Volume of Distribution in Drug Design.
J Med Chem 58: 5691-8 (2015)
Pharmacokinetics
Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J Med Chem 59: 1410-24 (2016)
Glaxosmithkline
An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors.
Bioorg Chem 59: 145-50 (2015)
Kyushu Institute Of Technology
Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators.
Bioorg Med Chem 23: 2195-203 (2015)
Research Triangle Institute
A combination of in silico and SAR studies to identify binding hot spots of Bcl-xL inhibitors.
Bioorg Med Chem 23: 1747-57 (2015)
Bioprojet-Biotech
Recent advances in the chemistry and biology of pyridopyrimidines.
Eur J Med Chem 95: 76-95 (2015)
Universit£
Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.
J Med Chem 58: 3172-87 (2015)
Cermn
Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: success and challenges.
Eur J Med Chem 95: 35-40 (2015)
Zhengzhou University
Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.
Eur J Med Chem 95: 29-34 (2015)
University Of Sydney
Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
Eur J Med Chem 95: 1-15 (2015)
Shandong University
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization.
Bioorg Med Chem Lett 25: 1724-9 (2015)
Gedeon Richter
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
J Med Chem 58: 3522-33 (2015)
Astrazeneca
Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptora1 for the treatment of pain.
J Med Chem 58: 2958-66 (2015)
University Of Pittsburgh
Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.
Chem Biol Drug Des 86: 849-56 (2015)
China Pharmaceutical University
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.
J Med Chem 58: 3209-22 (2015)
Universit£
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Bioorg Med Chem 23: 1701-15 (2015)
Virginia Commonwealth University
Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin.
Bioorg Med Chem 23: 2819-27 (2015)
University Of W£Rzburg
Azachalcones: a new class of potent polyphenol oxidase inhibitors.
Bioorg Med Chem Lett 25: 1753-6 (2015)
University Of Technology Sydney
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.
Bioorg Med Chem Lett 25: 1782-6 (2015)
Novartis Pharma
Discovery of a Cyclic Boronic Acidß-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J Med Chem 58: 3682-92 (2015)
Rempex Pharmaceuticals
Synthesis and bioactivity ofß-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
J Med Chem 58: 2988-3001 (2015)
Universiteit Gent
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
J Med Chem 58: 3223-52 (2015)
The Scripps Research Institute
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.
J Med Chem 58: 3253-67 (2015)
Universit£
Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38aMAPK and ERK1/2 inhibitory activity.
Eur J Med Chem 94: 397-404 (2015)
Cairo University
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.
Eur J Med Chem 94: 348-66 (2015)
Sichuan University
Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL).
Bioorg Med Chem 23: 2904-16 (2015)
Graz University Of Technology
N-benzoyl-1,5-benzothiazepine and its S-oxide as vasopressin receptor ligands: insight into the active stereochemistry around the seven-membered ring.
J Med Chem 58: 3268-73 (2015)
Teikyo University
Sulfonamide inhibition studies of the¿-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
Bioorg Med Chem 23: 1728-34 (2015)
Universit£
Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.
Bioorg Med Chem 23: 1776-87 (2015)
Kyoto University
Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold.
Bioorg Med Chem 23: 1858-68 (2015)
Zhejiang University
Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor.
Bioorg Med Chem 23: 1841-8 (2015)
University Of Arizona
?-sheet interfering molecules acting against ?-amyloid aggregation and fibrillogenesis.
Bioorg Med Chem 23: 1671-83 (2015)
Sapienza University Of Rome
Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea.
J Nat Prod 78: 822-6 (2015)
University Of Prince Edward Island
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.
Eur J Med Chem 94: 252-64 (2015)
Universit£
A facile synthesis and microtubule-destabilizing properties of 4-(1H-benzo[d]imidazol-2-yl)-furazan-3-amines.
Eur J Med Chem 94: 237-51 (2015)
Special Design And Construction Bureau Sdcb&Quot;Technolog&Quot
Synthesis, biological evaluation and molecular modeling studies of the PPARß/d antagonist CC618.
Eur J Med Chem 94: 229-36 (2015)
University Of Oslo
Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold.
Eur J Med Chem 94: 218-28 (2015)
Shandong University
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.
Eur J Med Chem 94: 195-210 (2015)
Universiti Sains Malaysia
Truncated structures used in search for new lead compounds and in a retrospective analysis of thienopyrimidine-based EGFR inhibitors.
Eur J Med Chem 94: 175-94 (2015)
Norwegian University Of Science And Technology
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
Eur J Med Chem 94: 163-74 (2015)
Sapienza University Of Rome
Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action.
Eur J Med Chem 94: 149-62 (2015)
Universit£
Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
Bioorg Med Chem 23: 1386-94 (2015)
The University Of Michigan Medical School
Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2).
Bioorg Med Chem 23: 4034-49 (2015)
Westf£Lische Wilhelms-Universit£T M£Nster
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.
Bioorg Med Chem 23: 1828-40 (2015)
Universit£
Development of 2-amino-5-phenylthiophene-3-carboxamide derivatives as novel inhibitors of Mycobacterium tuberculosis DNA GyrB domain.
Bioorg Med Chem 23: 1402-12 (2015)
Birla Institute Of Technology
Synthesis of a chondroitin sulfate disaccharide library and a GAG-binding protein interaction analysis.
Bioorg Med Chem Lett 25: 1407-11 (2015)
Kagoshima University
Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists.
Bioorg Med Chem Lett 25: 1546-51 (2015)
Korea Institute Of Science And Technology
Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro.
Bioorg Med Chem Lett 25: 1730-5 (2015)
Xi'An Jiaotong University
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.
Eur J Med Chem 94: 132-9 (2015)
University Of Naples
Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors.
Eur J Med Chem 94: 123-31 (2015)
The University Of Arizona
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.
J Med Chem 58: 2799-808 (2015)
Bristol-Myers Squibb
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.
J Med Chem 58: 3366-92 (2015)
Entremed
Niraparib: A Poly(ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination.
J Med Chem 58: 3302-14 (2015)
Istituto Di Ricerche Di Biologia Molecolare
3'-functionalized adamantyl cannabinoid receptor probes.
J Med Chem 58: 3104-16 (2015)
University Of Hawaii At Manoa
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT1A and 5-HT7 receptor ligands.
Bioorg Med Chem Lett 25: 1427-30 (2015)
Universit£
Design, synthesis and docking study of novel tetracyclic oxindole derivatives asa-glucosidase inhibitors.
Bioorg Med Chem Lett 25: 1471-5 (2015)
Key Laboratory Of Industrial Fermentation Microbiology (Tianjin University Of Science And Technology)
(18)F-AmBF3-MJ9: a novel radiofluorinated bombesin derivative for prostate cancer imaging.
Bioorg Med Chem 23: 1500-6 (2015)
Bc Cancer Agency
New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity.
Bioorg Med Chem 23: 1421-9 (2015)
Siedlce University Of Natural Sciences And Humanities
Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells.
Eur J Med Chem 94: 87-101 (2015)
Csir-Indian Institute Of Chemical Technology
Bacillusin A, an Antibacterial Macrodiolide from Bacillus amyloliquefaciens AP183.
J Nat Prod 78: 924-8 (2015)
Lucigen
The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
Bioorg Med Chem Lett 25: 1443-7 (2015)
Lexicon Pharmaceuticals
8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.
Bioorg Med Chem Lett 25: 1431-5 (2015)
Mitsubishi Tanabe Pharma
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.
Bioorg Med Chem Lett 25: 1787-91 (2015)
Novartis Pharma
Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.
Bioorg Med Chem 23: 1430-6 (2015)
Latvian Institute Of Organic Synthesis
Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptorß agonists.
Bioorg Med Chem Lett 25: 1377-80 (2015)
Eli Lilly
Syntheses of chondroitin sulfate tetrasaccharide structures containing 4,6-disulfate patterns and analysis of their interaction with glycosaminoglycan-binding protein.
Bioorg Med Chem Lett 25: 1552-5 (2015)
Kagoshima University
Loratadine analogues as MAGL inhibitors.
Bioorg Med Chem Lett 25: 1436-42 (2015)
University Of Eastern Finland
Synthesis and evaluation of tetrahydroindazole derivatives as sigma-2 receptor ligands.
Bioorg Med Chem 23: 1463-71 (2015)
Guangdong Medical College
Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.
J Med Chem 58: 2623-48 (2015)
Purdue University
Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors?Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.
Medchemcomm 5: 1821-1828 (2014)
Imperial College London
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.
Bioorg Med Chem Lett 25: 1390-3 (2015)
Karl-Franzens-University
Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.
Bioorg Med Chem Lett 25: 1479-82 (2015)
Ono Pharmaceutical
SAH derived potent and selective EZH2 inhibitors.
Bioorg Med Chem Lett 25: 1532-7 (2015)
Pfizer
The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues.
Bioorg Chem 59: 117-23 (2015)
North-West University
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
ACS Chem Biol 10: 1456-65 (2015)
University Of Illinois At Chicago
Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities.
Eur J Med Chem 93: 539-63 (2015)
Mazandaran University Of Medical Sciences
LEADOPT: an automatic tool for structure-based lead optimization, and its application in structural optimizations of VEGFR2 and SYK inhibitors.
Eur J Med Chem 93: 523-38 (2015)
Sichuan University
Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.
Eur J Med Chem 93: 501-10 (2015)
University Of Otago
Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
J Med Chem 58: 3060-82 (2015)
Euroscreen
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
J Med Chem 58: 2834-44 (2015)
Astrazeneca
Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists.
Bioorg Med Chem 23: 4013-25 (2015)
Leiden University
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.
Bioorg Med Chem Lett 25: 1597-602 (2015)
Merck Serono
Novelß-amyloid aggregation inhibitors possessing a turn mimic.
Bioorg Med Chem Lett 25: 1572-6 (2015)
Kobe Pharmaceutical University
Design, synthesis and preliminary biological evaluation of C-8 substituted guanine derivatives as small molecular inhibitors of FGFRs.
Bioorg Med Chem Lett 25: 1556-60 (2015)
Health Science Center Xi'An Jiaotong University
Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) agonists.
Bioorg Med Chem 23: 1613-28 (2015)
The Beckman Research Institute
Perturbation of the c-Myc-Max protein-protein interaction via synthetic ?-helix mimetics.
J Med Chem 58: 3002-24 (2015)
University Of Maryland
Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.
J Med Chem 58: 2809-20 (2015)
Roche Innovation Center Shanghai
Peroxisome Proliferator-Activated Receptor¿ (PPAR¿) and Ligand Choreography: Newcomers Take the Stage.
J Med Chem 58: 5381-94 (2015)
Universitat Rovira I Virgili (Urv)
Molecular determinants of biased agonism at the dopamine D2 receptor.
J Med Chem 58: 2703-17 (2015)
Friedrich-Alexander University
Synthesis, biological investigation and molecular docking study of N-malonyl-1,2-dihydroisoquinoline derivatives as brain specific and shelf-stable MAO inhibitors.
Eur J Med Chem 93: 481-91 (2015)
Assiut University
10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.
J Med Chem 58: 3131-43 (2015)
Technische Universit£T Braunschweig
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.
J Med Chem 58: 2779-98 (2015)
Universit£
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
Bioorg Med Chem Lett 25: 1592-6 (2015)
Merck Research Laboratories
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett 25: 1635-42 (2015)
Bristol-Myers Squibb
Identification of fused 16ß,17ß-oxazinone-estradiol derivatives as a new family of non-estrogenic 17ß-hydroxysteroid dehydrogenase type 1 inhibitors.
Eur J Med Chem 93: 470-80 (2015)
Universit£
(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.
Eur J Med Chem 93: 452-60 (2015)
University Of Cagliari
Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure.
J Med Chem 58: 2821-33 (2015)
Pfizer
Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells.
Bioorg Med Chem Lett 25: 1476-8 (2015)
Gansu College Of Traditional Chinese Medicine
Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.
Bioorg Med Chem 23: 1601-12 (2015)
John Hopkins University
2-Benzisothiazolylimino-5-benzylidene-4-thiazolidinones as protective agents against cartilage destruction.
Bioorg Med Chem 23: 1551-6 (2015)
University Of Catania
Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).
Eur J Med Chem 93: 392-400 (2015)
Stanford University School Of Medicine
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett 25: 1541-5 (2015)
Wenzhou Medical University
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.
J Med Chem 58: 147-69 (2015)
TBA
In silico studies, synthesis and binding evaluation of substituted 2-pyrrolidinones as peptidomimetics of RGD tripeptide sequence.
Eur J Med Chem 93: 360-72 (2015)
Universit£
Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.
J Med Chem 58: 2553-9 (2015)
Cancer Research Uk Cancer Therapeutics Unit
Discovery of hydroxyaniline amides as selective Extracellular Regulated Kinase (Erk) inhibitors.
Bioorg Med Chem Lett 25: 1627-9 (2015)
Merck Research Laboratories
Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa.
Bioorg Med Chem 23: 1638-50 (2015)
Technical University Of Denmark
A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
Chembiochem 16: 766-71 (2015)
Goethe Universität Frankfurt
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability.
J Med Chem 58: 2530-7 (2015)
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Synthesis and Evaluation of 3-(furo[2,3-b]pyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as Novel GSK-3ß Inhibitors and Anti-Ischemic Agents.
Chem Biol Drug Des 86: 746-52 (2015)
Zhejiang University Of Technology
Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes.
J Med Chem 58: 3315-28 (2015)
Chinese Academy Of Sciences
Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists.
Bioorg Med Chem Lett 25: 1616-20 (2015)
Astrazeneca
Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.
Bioorg Med Chem Lett 25: 1621-6 (2015)
Satori Pharmaceuticals
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.
Bioorg Med Chem 23: 1629-37 (2015)
Jagiellonian University Medical College
Computer-guided drug repurposing: identification of trypanocidal activity of clofazimine, benidipine and saquinavir.
Eur J Med Chem 93: 338-48 (2015)
National University Of La Plata (Unlp)
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.
Eur J Med Chem 93: 330-7 (2015)
Shandong University
Exploring new selective 3-benzylquinoxaline-based MAO-A inhibitors: design, synthesis, biological evaluation and docking studies.
Eur J Med Chem 93: 308-20 (2015)
Alexandria University
Synthesis, antioxidant and anticholinesterase activities of novel coumarylthiazole derivatives.
Bioorg Chem 59: 80-90 (2015)
Bezmialem Vakif University
2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists.
J Med Chem 58: 2658-77 (2015)
TBA
Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.
Bioorg Med Chem 23: 2810-8 (2015)
University Of Pittsburgh
Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents.
Eur J Med Chem 93: 291-9 (2015)
Nanjing University
Novel 1-(2-aryl-2-adamantyl)piperazine derivatives with antiproliferative activity.
Eur J Med Chem 93: 281-90 (2015)
University Of Athens
Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors.
Bioorg Med Chem 23: 1588-600 (2015)
University Of Florida
Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.
Bioorg Med Chem 23: 1377-85 (2015)
University Of Massachusetts Medical School
Novel tail and head group prostamide probes.
Bioorg Med Chem Lett 25: 1228-31 (2015)
Northeastern University
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.
Bioorg Med Chem Lett 25: 1212-6 (2015)
H. Lundbeck
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Bioorg Med Chem Lett 25: 1333-7 (2015)
Genentech
Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives.
Bioorg Med Chem Lett 25: 1206-11 (2015)
Yaroslavl State Technical University
Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases.
J Med Chem 58: 2350-7 (2015)
Csir-Indian Institute Of Chemical Technology
5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.
J Med Chem 58: 2560-6 (2015)
University Of Camerino
Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.
Chem Biol 22: 273-84 (2015)
University Of Florida College Of Medicine
Development of novel ACK1/TNK2 inhibitors using a fragment-based approach.
J Med Chem 58: 2746-63 (2015)
University Of South Florida
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
J Med Chem 58: 2417-30 (2015)
Amgen
Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors.
ACS Med Chem Lett 6: 187-91 (2015)
University Of Salerno
Treating pain with somatostatin receptor subtype 4 agonists.
ACS Med Chem Lett 6: 110-1 (2015)
Therachem Research Medilab (India)
The role of enhancer of zeste homologue 2 inhibitors in controlling epigenetics and their potential for cancer treatment.
ACS Med Chem Lett 6: 108-9 (2015)
Therachem Research Medilab (India)
Allosteric modulators: an emerging concept in drug discovery.
ACS Med Chem Lett 6: 104-7 (2015)
Therachem Research Medilab (India)
Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.
ACS Med Chem Lett 6: 216-20 (2015)
University Of Adelaide
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aß Reduction without Cardiovascular Liabilities.
ACS Med Chem Lett 6: 210-5 (2015)
Amgen
Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis.
ACS Med Chem Lett 6: 198-203 (2015)
University Of Lille
Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist.
ACS Med Chem Lett 6: 192-7 (2015)
Vrije Universiteit Brussel
Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands.
ACS Med Chem Lett 6: 178-82 (2015)
Uppsala University
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.
ACS Med Chem Lett 6: 173-7 (2015)
Sapienza University Of Rome
Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.
ACS Med Chem Lett 6: 162-7 (2015)
Rowan University
Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.
ACS Med Chem Lett 6: 156-61 (2015)
Pfizer
Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett 6: 140-5 (2015)
Vanderbilt University School Of Medicine
Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.
ACS Med Chem Lett 6: 123-7 (2015)
University Of Minnesota
Novel Pyridyloxadiazole Agonists of Sphingosin-1-phosphate.
ACS Med Chem Lett 6: 102-3 (2015)
Dart Neuroscience
Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids.
Bioorg Med Chem 23: 1284-306 (2015)
Ludwig-Maximilians-Universit£T M£Nchen
Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives.
Bioorg Med Chem Lett 25: 1318-23 (2015)
Glaxosmithkline
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.
J Med Chem 58: 2649-57 (2015)
Slovak Academy Of Sciences
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
J Med Chem 58: 2855-61 (2015)
Ensemble Therapeutics
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
J Med Chem 58: 2678-702 (2015)
Eurofarma Laboratorios
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.
J Nat Prod 78: 722-9 (2015)
City University Of New York
Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-ß-agarofuran Sesquiterpenes from Celastrus vulcanicola.
J Nat Prod 78: 736-45 (2015)
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
6,7-Dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives as selective inhibitors of PI3Ka.
Bioorg Med Chem 23: 1231-40 (2015)
Nanjing University
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
Bioorg Med Chem Lett 25: 1448-52 (2015)
Bristol-Myers Squibb
Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma.
Bioorg Med Chem Lett 25: 1217-22 (2015)
RhôNe-Poulenc Rorer
Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015.
J Nat Prod 78: 363-7 (2015)
Seoul National University
Exploitation of the ability of¿-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors.
J Med Chem 58: 2290-8 (2015)
The Ohio State University
Quantum chemistry calculation-aided structural optimization of combretastatin A-4-like tubulin polymerization inhibitors: improved stability and biological activity.
J Med Chem 58: 2538-46 (2015)
Second Military Medical University
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists.
Bioorg Med Chem Lett 25: 1196-205 (2015)
Bristol-Myers Squibb Research And Development (R & D)
Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies.
Bioorg Med Chem Lett 25: 1306-9 (2015)
B. V. Patel Pharmaceutical Education And Research Development (Perd) Centre
Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: from potent activators to highly efficient inhibitors.
Eur J Med Chem 93: 255-62 (2015)
Sun Yat-Sen University
Myxochelins target human 5-lipoxygenase.
J Nat Prod 78: 335-8 (2015)
Leibniz-Institute For Natural Product Research And Infection Biology
Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.
J Med Chem 58: 2465-88 (2015)
University Of Navarra
Solid-Supported Synthesis and 5-HT7 /5-HT1A Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1H)-one.
Chem Biol Drug Des 86: 697-703 (2015)
Jagiellonian University Medical College
3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.
Bioorg Med Chem 23: 1321-40 (2015)
Virginia Tech
Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1).
Bioorg Med Chem 23: 1356-65 (2015)
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Synthesis and biological evaluation of 4-nitroindole derivatives as 5-HT2A receptor antagonists.
Bioorg Med Chem 23: 1313-20 (2015)
Ewha Womans University
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
Bioorg Med Chem Lett 25: 1310-7 (2015)
Janssen Pharmaceutica
Pyrido-imidazodiazepinones as a new class of reversible inhibitors of human kallikrein 7.
Eur J Med Chem 93: 202-13 (2015)
University Of Montpellier
Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.
Eur J Med Chem 93: 196-201 (2015)
Islamic Azad University
Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin.
Eur J Med Chem 93: 182-95 (2015)
Peking University
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
J Med Chem 58: 1717-35 (2015)
The Institute Of Cancer Research
A binding mode hypothesis of tiagabine confirms liothyronine effect on¿-aminobutyric acid transporter 1 (GAT1).
J Med Chem 58: 2149-58 (2015)
University Of Vienna
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J Med Chem 58: 2180-94 (2015)
Abbvie
Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors.
Bioorg Med Chem 23: 953-9 (2015)
The University Of Tokyo
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Bioorg Med Chem 23: 5156-67 (2015)
Universitat De Barcelona
Rat hormone sensitive lipase inhibition by cyclipostins and their analogs.
Bioorg Med Chem 23: 944-52 (2015)
University Of Missouri St. Louis
Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem 23: 911-23 (2015)
Sichuan University
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.
Bioorg Med Chem Lett 25: 1338-42 (2015)
Vertex Pharmaceuticals
Design and discovery of 2-oxochromene derivatives as liver X receptorß-selective agonists.
Bioorg Med Chem Lett 25: 1274-8 (2015)
Kowa
Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain.
Bioorg Med Chem Lett 25: 1324-8 (2015)
Yonsei University
A novel molecule with notable activity against multi-drug resistant tuberculosis.
Bioorg Med Chem Lett 25: 1269-73 (2015)
University Of Georgia
Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine.
Chembiochem 16: 819-26 (2015)
University Of Groningen
Selective, nontoxic CB(2) cannabinoid o-quinone with in vivo activity against triple-negative breast cancer.
J Med Chem 58: 2256-64 (2015)
Instituto De Qu£Mica M£Dica
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
J Med Chem 58: 1669-90 (2015)
Boehringer Ingelheim Pharmaceuticals
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.
J Med Chem 58: 2135-48 (2015)
Universit£
C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.
J Med Chem 58: 2431-40 (2015)
Universit£
When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.
Eur J Med Chem 93: 121-34 (2015)
Leiden University
Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.
Bioorg Med Chem Lett 25: 1044-6 (2015)
Yale University
Synthesis and SAR study of potent and selective PI3Kd inhibitors.
Bioorg Med Chem Lett 25: 1104-9 (2015)
Amgen
Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.
Bioorg Med Chem Lett 25: 1009-11 (2015)
Universit£
Marine natural products as inhibitors of cystathionine beta-synthase activity.
Bioorg Med Chem Lett 25: 1064-6 (2015)
University Of Utah
Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat.
Bioorg Med Chem Lett 25: 1030-5 (2015)
Arena Pharmaceuticals
2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H.
Bioorg Chem 59: 12-22 (2015)
Kurukshetra University
Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3ß inhibitors and neuroprotective agents.
Bioorg Med Chem 23: 1179-88 (2015)
Zhejiang University
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Bioorg Med Chem 23: 996-1010 (2015)
Canisius College
Rational design, synthesis and structure-activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors.
Bioorg Med Chem 23: 924-31 (2015)
Sun Yat-Sen University
Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
Eur J Med Chem 93: 101-8 (2015)
Seoul National University
Synthesis and biological evaluation of pyridazino[1',6':1,2]pyrido[3,4-b]indolinium and pyridazino[1,6-a]benzimidazolium salts as anti-inflammatory agents.
Eur J Med Chem 93: 83-92 (2015)
Instituto De Salud Hospital Universitario La Paz - Idipaz
Design, synthesis and docking studies of novel thienopyrimidine derivatives bearing chromone moiety as mTOR/PI3Ka inhibitors.
Eur J Med Chem 93: 64-73 (2015)
Jiangxi Science & Technology Normal University
Synthesis and structure-activity relationship study of a new series of selectives(1) receptor ligands for the treatment of pain: 4-aminotriazoles.
J Med Chem 58: 2441-51 (2015)
Esteve
Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.
J Med Chem 58: 2299-314 (2015)
Amgen
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
Eur J Med Chem 93: 42-50 (2015)
China Pharmaceutical University
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.
Bioorg Med Chem Lett 25: 1047-52 (2015)
Teva Branded Pharmaceutical Products R & D
Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3ß inhibitors for Alzheimer's disease.
Bioorg Med Chem Lett 25: 1086-91 (2015)
Mitsubishi Tanabe Pharma
Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.
J Med Chem 58: 2275-89 (2015)
F. Hoffmann-La Roche
Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.
Bioorg Med Chem 23: 4000-12 (2015)
National Institute On Drug Abuse-Intramural Research Program
Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.
Bioorg Med Chem 23: 1102-11 (2015)
Georgetown University
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.
Bioorg Med Chem 23: 1123-34 (2015)
Chang Gung University
Computer-aided discovery of aminopyridines as novel JAK2 inhibitors.
Bioorg Med Chem 23: 985-95 (2015)
Chonnam National University
Transporter-mediated tissue targeting of therapeutic molecules in drug discovery.
Bioorg Med Chem Lett 25: 993-7 (2015)
Eli Lilly
Cell-based and virtual fragment screening for adrenergica2C receptor agonists.
Bioorg Med Chem 23: 3991-9 (2015)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.
Discovery of phenylpiperazine derivatives as IGF-1R inhibitor with potent antiproliferative properties in vitro.
Bioorg Med Chem Lett 25: 1067-71 (2015)
Shandong University Of Technology
Synthesis and biological evaluation of second-generation tropanol-based androgen receptor modulators.
J Med Chem 58: 1569-74 (2015)
University Of Gothenburg
Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor.
Eur J Med Chem 93: 16-32 (2015)
Zhejiang University
Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.
J Med Chem 58: 2326-49 (2015)
Astrazeneca
Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.
J Med Chem 58: 1879-99 (2015)
Virginia Tech
Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay.
J Med Chem 58: 2547-52 (2015)
University Of Strasburg
Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.
J Med Chem 58: 1691-704 (2015)
Universit£
Chalcones and their therapeutic targets for the management of diabetes: structural and pharmacological perspectives.
Eur J Med Chem 92: 839-65 (2015)
Guru Ghasidas Vishwavidyalaya (A Central University)
Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs.
Bioorg Med Chem 23: 1069-81 (2015)
Volgograd State Medical University
Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists.
Bioorg Med Chem 23: 1157-68 (2015)
Zhejiang University
GPCR crystal structures: Medicinal chemistry in the pocket.
Bioorg Med Chem 23: 3880-906 (2015)
Friedrich-Alexander University
6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands.
Eur J Med Chem 92: 807-17 (2015)
Universities Of Lille
Discovery of biphenyl-based VEGFR-2 inhibitors. Part 3: design, synthesis and 3D-QSAR studies.
Bioorg Med Chem 23: 1044-54 (2015)
Xi'An Jiaotong University
Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors.
Bioorg Med Chem 23: 1055-61 (2015)
National Institute Of Health Sciences
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Bioorg Med Chem 23: 5151-5 (2015)
St. Jude Children'S Research Hospital
Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.
Eur J Med Chem 92: 799-806 (2015)
Tehran University Of Medical Sciences
Structure-guided design of a high affinity inhibitor to human CtBP.
ACS Chem Biol 10: 1118-27 (2015)
University Of Massachusetts Medical School
3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties.
J Med Chem 58: 1524-43 (2015)
National Center For Scientific Research&Quot;Demokritos&Quot
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
J Med Chem 58: 1964-75 (2015)
Indiana University
PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.
J Med Chem 58: 2091-113 (2015)
Mayo Clinic
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
J Med Chem 58: 1992-2002 (2015)
University Of Illinois At Chicago
Discovery and profiling of a selective and efficacious Syk inhibitor.
J Med Chem 58: 1950-63 (2015)
Novartis Institutes For Biomedical Research
A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists.
Eur J Med Chem 92: 784-98 (2015)
National University Of Singapore
Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg Med Chem Lett 25: 1117-23 (2015)
Mcgill University
Target engagement in lead generation.
Bioorg Med Chem Lett 25: 998-1008 (2015)
Eli Lilly
Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): first-in-class dual pharmacology multivalent muscarinic antagonist..
J Med Chem 58: 2609-22 (2015)
Theravance Biopharma
Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent.
J Med Chem 58: 1795-805 (2015)
Lanzhou University
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
J Med Chem 58: 1915-28 (2015)
Universit£
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
J Med Chem 58: 1400-19 (2015)
A* Star
Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi.
Chem Biol Drug Des 86: 626-36 (2015)
Chinese Academy Of Sciences
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.
Eur J Med Chem 92: 754-65 (2015)
Shandong University
Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
J Med Chem 58: 1760-75 (2015)
Shionogi Pharmaceutical Research Center
Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
J Med Chem 58: 1929-39 (2015)
Merck
Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.
J Med Chem 58: 3672-81 (2015)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.
Bioorg Med Chem 23: 1135-48 (2015)
University Of Delhi
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase andß-amyloid aggregation inhibitors with neuroprotective properties.
Eur J Med Chem 92: 738-49 (2015)
Jagiellonian University Medical College
Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.
J Med Chem 58: 1846-61 (2015)
Translational Research Institute
Design and Biological Evaluation of Furan/Pyrrole/Thiophene-2-carboxamide Derivatives as Efficient DNA GyraseB Inhibitors of Staphylococcus aureus.
Chem Biol Drug Des 86: 918-25 (2015)
Birla Institute Of Technology
Computer-aided identification of novel anticancer compounds with a possible dual HER1/HER2 inhibition mechanism.
Bioorg Med Chem Lett 25: 758-62 (2015)
Cardiff University
Tampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions.
Chembiochem 16: 432-9 (2015)
Universit?? Pierre Et Marie Curie
Design and synthesis of N-methylpyrimidone derivatives as HIV-1 integrase inhibitors.
Bioorg Med Chem 23: 735-41 (2015)
Beijing University Of Technology
Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.
Eur J Med Chem 92: 723-31 (2015)
Universit£Tsmedizin G£Ttingen
Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.
Bioorg Med Chem Lett 25: 775-80 (2015)
Amgen
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-¿B p50.
J Nat Prod 78: 208-17 (2015)
National University Of Singapore
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Bioorg Med Chem 23: 668-80 (2015)
Sichuan University
Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity.
Bioorg Med Chem 23: 657-67 (2015)
Southeast University
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Bioorg Med Chem 23: 742-52 (2015)
Csir-Central Drug Research Institute
Development of 2-aminooxazoline 3-azaxanthenes as orally efficaciousß-secretase inhibitors for the potential treatment of Alzheimer's disease.
Bioorg Med Chem Lett 25: 767-74 (2015)
Amgen
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Bioorg Med Chem Lett 25: 4992-9 (2015)
Merck Research Laboratories
Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression.
J Nat Prod 78: 188-95 (2015)
Institute Of Microbial Chemistry (Bikaken)
Structural investigation of B-Raf paradox breaker and inducer inhibitors.
J Med Chem 58: 1818-31 (2015)
Umr Cnrs-Universit£
Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents.
J Med Chem 58: 1705-16 (2015)
Zhengzhou University
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
J Med Chem 58: 1976-91 (2015)
Array Biopharma
Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands.
Eur J Med Chem 92: 575-82 (2015)
University Of Lille
Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones.
J Med Chem 58: 1254-67 (2015)
Birla Institute Of Technology
Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.
J Med Chem 58: 1064-6 (2015)
Vibrant Pharma
Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.
J Med Chem 58: 1479-93 (2015)
Duquesne University
Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
ACS Chem Biol 10: 925-32 (2015)
University Of California Berkeley
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Bioorg Med Chem 23: 770-8 (2015)
Dart Neuroscience
Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.
Bioorg Med Chem 23: 797-802 (2015)
Tohoku Pharmaceutical University
Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor.
Eur J Med Chem 92: 554-64 (2015)
Institute Of Pharmaceutical Sciences
Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Eur J Med Chem 92: 531-9 (2015)
National Institute On Drug Abuse
Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.
Bioorg Med Chem Lett 25: 887-92 (2015)
Dr. Reddy'S Laboratories
Thiol-derivatized minihepcidins retain biological activity.
Bioorg Med Chem Lett 25: 763-6 (2015)
University Of California Los Angeles
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.
Bioorg Med Chem Lett 25: 1140-5 (2015)
Boehringer Ingelheim (Canada)
Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62.
J Med Chem 58: 2114-34 (2015)
Gwangju Institute Of Science And Technology (Gist)
Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.
Bioorg Med Chem Lett 25: 799-802 (2015)
Sungkyunkwan University
6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists.
Bioorg Med Chem Lett 25: 803-6 (2015)
Shenyang Pharmaceutical University
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
Bioorg Med Chem Lett 25: 807-10 (2015)
Universit£
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.
Bioorg Med Chem Lett 25: 940-3 (2015)
Vertex Pharmaceuticals
The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.
Bioorg Med Chem Lett 25: 834-40 (2015)
Amgen
Iminosugars as a new class of cholinesterase inhibitors.
Bioorg Med Chem Lett 25: 830-3 (2015)
University Of Strasburg
Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors.
Bioorg Med Chem 23: 810-20 (2015)
Sapienza University Of Rome
Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold.
Bioorg Med Chem 23: 891-901 (2015)
China Pharmaceutical University
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability.
Bioorg Med Chem 23: 779-90 (2015)
Sumitomo Dainippon Pharma
Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators.
Bioorg Med Chem Lett 25: 956-9 (2015)
Janssen Research And Development
Two new protein tyrosine phosphatase 1B inhibitors, hyattellactones A and B, from the Indonesian marine sponge Hyattella sp.
Bioorg Med Chem Lett 25: 904-7 (2015)
Tohoku Pharmaceutical University
Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors.
Eur J Med Chem 92: 459-70 (2015)
Cairo University
Glycosylated enfuvirtide: a long-lasting glycopeptide with potent anti-HIV activity.
J Med Chem 58: 1372-9 (2015)
Chinese Academy Of Sciences
Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template.
Bioorg Med Chem 23: 821-8 (2015)
Wayne State University
Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.
Bioorg Med Chem 23: 803-9 (2015)
Tokyo Medical And Dental University
Potency enhancement of the¿-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.
Bioorg Med Chem 23: 3948-56 (2015)
University Of Kansas Specialized Chemistry Center
Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting theß2 adrenoceptor.
Bioorg Med Chem Lett 25: 820-5 (2015)
Instituto Polit£Cnico Nacional (Ipn)
Pyridine and pyridinone-based factor XIa inhibitors.
Bioorg Med Chem Lett 25: 925-30 (2015)
Bristol-Myers Squibb
Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.
Bioorg Med Chem Lett 25: 919-24 (2015)
Washington University
Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer.
J Med Chem 58: 2077-87 (2015)
University Of Maryland
Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors.
Eur J Med Chem 92: 427-38 (2015)
Central China Normal University
Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.
J Med Chem 58: 1550-5 (2015)
Monash University (Parkville Campus)
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.
ACS Chem Biol 10: 1072-81 (2015)
University Of North Carolina At Chapel Hill
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease.
J Med Chem 58: 1159-83 (2015)
Evotec (Uk)
Hupehenols A-E, selective 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors from Viburnum hupehense.
J Nat Prod 78: 330-4 (2015)
Chinese Academy Of Sciences
Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101.
ACS Med Chem Lett 6: 95-9 (2015)
Northeastern University
Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS Med Chem Lett 6: 89-94 (2015)
Eisai
Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.
ACS Med Chem Lett 6: 84-8 (2015)
Lexicon Pharmaceuticals
Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.
ACS Med Chem Lett 6: 79-83 (2015)
University Of Zurich
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors.
ACS Med Chem Lett 6: 73-8 (2015)
Sanofi R & D
Unfolded Protein Response in Cancer: IRE1a Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.
ACS Med Chem Lett 6: 68-72 (2015)
Amgen
Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.
ACS Med Chem Lett 6: 63-7 (2015)
Astex Pharmaceuticals
Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.
ACS Med Chem Lett 6: 58-62 (2015)
Abbvie
Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.
ACS Med Chem Lett 6: 53-7 (2015)
Lexicon Pharmaceuticals
Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors.
ACS Med Chem Lett 6: 42-6 (2015)
Novartis Institutes For Biomedical Research
Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-a]pyrazines as ATR Inhibitors.
ACS Med Chem Lett 6: 37-41 (2015)
Novartis Institutes For Biomedical Research
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
ACS Med Chem Lett 6: 31-6 (2015)
Astex Pharmaceuticals
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
ACS Med Chem Lett 6: 25-30 (2015)
Astex Pharmaceuticals
Novel Disubstituted Pyrimidines as Inhibitors of Bruton's Tyrosine Kinase.
ACS Med Chem Lett 6: 23-4 (2015)
Dart Neuroscience
Pyrrolopyridines-quinazolines Inhibitors of PKR-Like ER Kinase.
ACS Med Chem Lett 6: 21-2 (2015)
Dart Neuroscience
Novel azaindazole sulfonamides inhibitors of serum and glucocorticoid regulated kinase.
ACS Med Chem Lett 6: 19-20 (2015)
Dart Neuroscience
P21-Activated Kinase 4 (PAK4) Inhibitors as Potential Cancer Therapy.
ACS Med Chem Lett 6: 17-8 (2015)
Therachem Research Medilab (India)
Quinalozinones as Inhibitors of Class I PI3K Kinases.
ACS Med Chem Lett 6: 15-6 (2015)
Dart Neuroscience
RET Kinase Inhibitors May Treat Cancer and Gastrointestinal Disorders.
ACS Med Chem Lett 6: 13-4 (2015)
Therachem Research Medilab (India)
Dual leucine zipper kinase inhibitors: potential treatments for neurodegenerative diseases.
ACS Med Chem Lett 6: 11-2 (2015)
Therachem Research Medilab (India)
Pyrrolopyrimidine Analogues as MKNK Inhibitors.
ACS Med Chem Lett 6: 9-10 (2015)
Dart Neuroscience
Combination of novel imidazopyridazine mps-1 kinase inhibitors and bcl-2 family protein inhibitors.
ACS Med Chem Lett 6: 7-8 (2015)
Dart Neuroscience
Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.
ACS Med Chem Lett 6: 3-6 (2015)
Monash University (Parkville Campus)
Sesquiterpenoid tropolone glycosides from Liriosma ovata.
J Nat Prod 78: 315-9 (2015)
Food And Drug Administration
Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK).
J Med Chem 58: 1426-41 (2015)
Amgen
Pachymodulin, a new functional formyl peptide receptor 2 peptidic ligand isolated from frog skin has Janus-like immunomodulatory capacities.
J Med Chem 58: 1089-99 (2015)
Sorbonne University
Synthesis of novel inhibitors ofa-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies.
Eur J Med Chem 92: 387-400 (2015)
Universiti Teknologi Mara (Uitm)
Further insights into the SAR of ?-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.
Eur J Med Chem 92: 377-86 (2015)
University Of Parma
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
J Med Chem 58: 1556-62 (2015)
Bristol-Myers Squibb Research
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.
Bioorg Med Chem 23: 499-514 (2015)
Goethe-University Frankfurt
Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists.
Bioorg Med Chem 23: 3933-7 (2015)
University Of Copenhagen
Discovery of indole-derived pyridopyrazine-1,6-dione¿-secretase modulators that target presenilin.
Bioorg Med Chem Lett 25: 908-13 (2015)
Pfizer
Development of novel Asf1-H3/H4 inhibitors.
Bioorg Med Chem Lett 25: 963-8 (2015)
Colorado State University
The Synthesis and Evaluation of C7-Substituted a-Tetralone Derivatives as Inhibitors of Monoamine Oxidase.
Chem Biol Drug Des 86: 895-904 (2015)
North-West University
Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.
J Med Chem 58: 1494-501 (2015)
Griffith University
Discovery of small molecule inhibitors to Krüppel-like factor 10 (KLF10): implications for modulation of T regulatory cell differentiation.
J Med Chem 58: 1466-78 (2015)
Beth Israel Deaconess Medical Center
Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.
J Med Chem 58: 1123-39 (2015)
East China University Of Science And Techology
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.
Medchemcomm 5: 1863-1870 (2014)
Medical University Of South Carolina
Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.
Bioorg Med Chem Lett 25: 944-7 (2015)
Vertex Pharmaceuticals
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Bioorg Med Chem Lett 25: 444-50 (2015)
Merck Research Laboratories
Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies.
Eur J Med Chem 92: 314-31 (2015)
Universidad Nacional Aut£Noma De M£Xico
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Bioorg Med Chem Lett 25: 841-6 (2015)
Goethe-University Frankfurt
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
Bioorg Med Chem Lett 25: 587-92 (2015)
Boehringer Ingelheim Pharmaceuticals
Structure-based design of low-nanomolar PIM kinase inhibitors.
Bioorg Med Chem Lett 25: 474-80 (2015)
Biogen Idec
Structure-based design and optimization of potent inhibitors of the adenoviral protease.
Bioorg Med Chem Lett 25: 438-43 (2015)
Novartis Institute For Biomedical Research
A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.
J Med Chem 58: 1563-8 (2015)
St. Jude Children'S Research Hospital
Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition.
J Med Chem 58: 1544-9 (2015)
Tokyo University Of Pharmacy And Life Sciences
Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.
J Med Chem 58: 3287-301 (2015)
Chinese Academy Of Sciences
Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
J Med Chem 58: 1358-71 (2015)
Roche Pharmaceutical Research And Early Development
Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding.
Bioorg Med Chem 23: 3938-47 (2015)
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Bioorg Med Chem Lett 25: 459-61 (2015)
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies.
J Nat Prod 78: 69-76 (2015)
National Research Council
Insulin-mimetic selaginellins from Selaginella tamariscina with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.
J Nat Prod 78: 34-42 (2015)
Catholic University Of Daegu
Design, synthesis and evaluation of isoxazolo[5,4-d]pyrimidin-4(5H)-one derivatives as antithrombotic agents.
Bioorg Med Chem Lett 25: 492-5 (2015)
Southeast University
Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization.
J Med Chem 58: 1281-97 (2015)
Shanghai Institute Of Materia Medica
Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.
J Med Chem 58: 1337-44 (2015)
University Of Massachusetts Medical School
Highly selective salicylketoxime-based estrogen receptorß agonists display antiproliferative activities in a glioma model.
J Med Chem 58: 1184-94 (2015)
Universit£
Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities.
Eur J Med Chem 92: 270-81 (2015)
Zhejiang University
Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor.
Eur J Med Chem 92: 246-56 (2015)
Piramal Enterprises
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.
J Med Chem 58: 1228-43 (2015)
The University Of Georgia
Additivity or cooperativity: which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?
Eur J Med Chem 90: 897-915 (2015)
The State University Of New York
Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).
J Med Chem 58: 860-77 (2015)
Institut Pasteur
Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.
Medchemcomm 5: 268-276 (2014)
University Of Michigan
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Eur J Med Chem 92: 221-35 (2015)
Jagiellonian University Collegium Medicum
Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors.
Bioorg Med Chem Lett 25: 431-4 (2015)
China Pharmaceutical University
Selective CB2 receptor agonists. Part 1: the identification of novel ligands through computer-aided drug design (CADD) approaches.
Bioorg Med Chem Lett 25: 575-80 (2015)
Boehringer Ingelheim Pharmaceuticals
Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.
Bioorg Med Chem Lett 25: 519-23 (2015)
Washington University
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.
Bioorg Med Chem Lett 25: 602-6 (2015)
West Chester University
Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.
Bioorg Med Chem Lett 25: 581-6 (2015)
Boehringer Ingelheim Pharma
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett 25: 529-41 (2015)
Genentech
Synthesis and biological evaluation of isoindoloisoquinolinone, pyroloisoquinolinone and benzoquinazolinone derivatives as poly(ADP-ribose) polymerase-1 inhibitors.
Bioorg Med Chem 23: 488-98 (2015)
Pondicherry University
Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.
Bioorg Med Chem 23: 455-65 (2015)
Xenon Pharmaceuticals
Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.
Eur J Med Chem 92: 202-11 (2015)
Jagiellonian University Medical College
Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.
Eur J Med Chem 92: 178-90 (2015)
Sichuan University
Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: synthesis and anticancer activity.
Eur J Med Chem 90: 889-96 (2015)
Anhui Medical University
Structure-activity relationship studies of SETD8 inhibitors.
Medchemcomm 5: 1892-1898 (2014)
Icahn School Of Medicine At Mount Sinai
1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.
Eur J Med Chem 92: 156-77 (2015)
University Of Mississippi
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2.
Bioorg Med Chem 23: 3913-24 (2015)
Universit£
Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.
Eur J Med Chem 92: 145-55 (2015)
National University Of Singapore
Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors.
Eur J Med Chem 92: 124-34 (2015)
Cobra
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.
Eur J Med Chem 92: 115-23 (2015)
King Saud University
Identification and optimization of Escherichia coli GlmU inhibitors: an in silico approach with validation thereof.
Eur J Med Chem 92: 78-90 (2015)
Csir-Indian Institute Of Integrative Medicine
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Eur J Med Chem 92: 64-77 (2015)
Vrije Universiteit Brussel
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-ß-amyloid (Aß) aggregation and metal chelation properties against Alzheimer's disease.
Bioorg Med Chem Lett 25: 508-13 (2015)
China Pharmaceutical University
Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges.
Bioorg Med Chem Lett 25: 690-4 (2015)
Vanderbilt University Medical Center
Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors.
Bioorg Med Chem 23: 515-25 (2015)
Anhui Medical University
Identification and further development of potent TBK1 inhibitors.
ACS Chem Biol 10: 289-98 (2015)
Technical University Of Dortmund
Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem 23: 624-31 (2015)
Fudan University
Discovery and SAR study of c-Met kinase inhibitors bearing an 3-amino-benzo[d]isoxazole or 3-aminoindazole scaffold.
Bioorg Med Chem 23: 564-78 (2015)
China Pharmaceutical University
Structure-based design, synthesis and biological evaluation of novelß-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.
Bioorg Med Chem Lett 25: 668-72 (2015)
Purdue University
Sulfonamides as multifunctional agents for Alzheimer's disease.
Bioorg Med Chem Lett 25: 626-30 (2015)
University Of Massachusetts Boston
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 ß-lactamase and 6ß-(hydroxymethyl)penicillanic acid sulfone.
Biochemistry 54: 734-43 (2015)
Case Western Reserve University
Sulfonamide inhibition studies of the¿-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.
Bioorg Med Chem 23: 526-31 (2015)
Universit£
Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.
Bioorg Med Chem Lett 25: 642-8 (2015)
Universidad De Santiago De Compostela
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.
Bioorg Med Chem Lett 25: 659-63 (2015)
Arena Pharmaceuticals
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
Medchemcomm 4: 476-492 (2013)
University Of Minnesota
Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.
Bioorg Med Chem Lett 25: 708-16 (2015)
Soochow University
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.
Bioorg Med Chem Lett 25: 649-53 (2015)
Kyoto 607-8042
5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner.
Bioorg Med Chem Lett 25: 593-6 (2015)
Osaka Prefecture University
Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.
Bioorg Med Chem Lett 25: 631-4 (2015)
Shenyang Pharmaceutical University
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Bioorg Med Chem Lett 25: 717-20 (2015)
Bristol-Myers Squibb Research And Development
Synthesis and biological evaluation of picolinamides as potent inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).
Bioorg Med Chem Lett 25: 695-700 (2015)
Seoul National University
Triazinoindole analogs as potent inhibitors of a-glucosidase: synthesis, biological evaluation and molecular docking studies.
Bioorg Chem 58: 81-7 (2015)
Hazara University
Improving selectivity preserving affinity: new piperidine-4-carboxamide derivatives as effective sigma-1-ligands.
Eur J Med Chem 90: 797-808 (2015)
University Of Trieste
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Eur J Med Chem 90: 788-96 (2015)
Saarland University
Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system.
Bioorg Med Chem 23: 277-89 (2015)
Astellas Pharma
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.
J Med Chem 58: 651-64 (2015)
University Of Minnesota
Structure-based design of bacterial nitric oxide synthase inhibitors.
J Med Chem 58: 994-1004 (2015)
University Of California
Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome.
J Med Chem 58: 878-87 (2015)
Universit£
Total synthesis of clavatadine A.
J Nat Prod 78: 120-4 (2015)
Central Washington University
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
ACS Med Chem Lett 5: 1334-9 (2014)
Arena Pharmaceuticals
Crystal Structure of Sphingosine Kinase 1 with PF-543.
ACS Med Chem Lett 5: 1329-33 (2014)
University Of Oxford
Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.
ACS Med Chem Lett 5: 1318-23 (2014)
Boehringer Ingelheim Pharmaceuticals
Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.
ACS Med Chem Lett 5: 1313-7 (2014)
Arena Pharmaceuticals
Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).
ACS Med Chem Lett 5: 1308-12 (2014)
Institute
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.
ACS Med Chem Lett 5: 1284-9 (2014)
Amgen
Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.
ACS Med Chem Lett 5: 1272-7 (2014)
Uppsala University
Inhibition of O-GlcNAcase (OGA): A Potential Therapeutic Target to Treat Alzheimer's Disease.
ACS Med Chem Lett 5: 1270-1 (2014)
Therachem Research Medilab (India)
GnRH antagonists: the promise of treating sex-hormone-related diseases.
ACS Med Chem Lett 5: 1268-9 (2014)
Therachem Research Medilab (India)
Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem 23: 348-64 (2015)
China Pharmaceutical University
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
Bioorg Med Chem 23: 328-39 (2015)
The University Of Tokyo
Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kß and PI3Kd for the treatment of PTEN-deficient cancers.
J Med Chem 58: 943-62 (2015)
Astrazeneca
Novel fluoroalkyl derivatives of selective kappa opioid receptor antagonist JDTic: Design, synthesis, pharmacology and molecular modeling studies.
Eur J Med Chem 90: 742-50 (2015)
Universit£
Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase.
J Med Chem 58: 778-84 (2015)
Indiana University School Of Medicine
Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents.
Chem Biol Drug Des 86: 333-43 (2015)
Shandong University
Monoamine oxidase inhibitory activity of 2-aryl-4H-chromen-4-ones.
Bioorg Chem 58: 72-80 (2015)
Birla Institute Of Technology
Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.
Medchemcomm 5: 1496-1499 (2014)
Indiana University School Of Medicine
Synthesis and structure-activity relationships of pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles as potent inhibitors of tubulin polymerization.
Eur J Med Chem 90: 603-19 (2015)
Csir-Indian Institute Of Chemical Technology
Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.
Bioorg Med Chem Lett 25: 280-4 (2014)
Glaxosmithkline
Identification of a highly potent and selective CB2 agonist, RQ-00202730, for the treatment of irritable bowel syndrome.
Bioorg Med Chem Lett 25: 236-40 (2014)
Raqualia Pharma
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
Bioorg Med Chem Lett 25: 292-6 (2014)
Research Triangle Institute
Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.
Bioorg Med Chem Lett 25: 297-301 (2014)
University Of Waterloo
Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.
Bioorg Med Chem 23: 89-104 (2014)
Daiichi Sankyo
Bioactive constituents from the green alga Caulerpa racemosa.
Bioorg Med Chem 23: 38-45 (2014)
Nanchang University
1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.
Bioorg Med Chem 23: 9-21 (2014)
Universit£
Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model.
Bioorg Med Chem Lett 25: 229-35 (2014)
Boehringer Ingelheim Pharma
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptora/¿ ligand LT175.
Eur J Med Chem 90: 583-94 (2015)
Universit£
Synthesis, structural characterization and effect on human granulocyte intracellular cAMP levels of abscisic acid analogs.
Bioorg Med Chem 23: 22-32 (2014)
University Of Genoa
Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.
J Med Chem 57: 10486-98 (2014)
University Of Michigan Comprehensive Cancer Center And Departments Of Internal Medicine
(±)-Torreyunlignans A-D, rare 8-9' linked neolignan enantiomers as phosphodiesterase-9A inhibitors from Torreya yunnanensis.
J Nat Prod 77: 2651-7 (2014)
Sun Yat-Sen University
Identification of a novel orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor with efficacy in animal models of schizophrenia.
J Med Chem 58: 978-93 (2015)
Janssen Pharmaceutica
CNS drug design: balancing physicochemical properties for optimal brain exposure.
J Med Chem 58: 2584-608 (2015)
Eli Lilly
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
J Med Chem 58: 827-46 (2015)
The University Of Queensland
New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.
J Med Chem 58: 814-26 (2015)
University Of California
Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists.
Bioorg Med Chem Lett 25: 270-5 (2014)
National Institute Of Pharmaceutical Education And Research (Niper)
a2-adrenoceptor antagonists: synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and their derivatives.
J Med Chem 58: 963-77 (2015)
Trinity College
Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease.
J Med Chem 58: 718-38 (2015)
Monash University (Parkville Campus)
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.
J Med Chem 58: 1067-88 (2015)
Northwestern University
Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET.
Bioorg Med Chem Lett 25: 288-91 (2014)
University Of Toronto
Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.
Bioorg Med Chem Lett 25: 322-6 (2014)
Arena Pharmaceuticals
Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.
Bioorg Med Chem Lett 25: 313-6 (2014)
Kitasato University
Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
Bioorg Med Chem 23: 241-63 (2014)
University Of Oxford
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors.
J Med Chem 58: 753-66 (2015)
Astrazeneca
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.
Eur J Med Chem 90: 526-36 (2015)
Universit£
Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.
Bioorg Med Chem 23: 132-40 (2014)
China Pharmaceutical University
Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem.
Bioorg Med Chem Lett 25: 307-9 (2014)
Yonsei University
Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders.
J Med Chem 58: 96-110 (2015)
Nimbus Discovery
Rational design of partial agonists for the muscarinic m1 acetylcholine receptor.
J Med Chem 58: 560-76 (2015)
University Of W£Rzburg
Tetra-substituted pyridinylimidazoles as dual inhibitors of p38a mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.
J Med Chem 58: 443-56 (2015)
Eberhard Karls Universit£T T£Bingen
Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.
J Med Chem 57: 10443-54 (2014)
Nerviano Medical Sciences
Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors.
J Med Chem 57: 10544-50 (2014)
University Of Houston
Nintedanib: from discovery to the clinic.
J Med Chem 58: 1053-63 (2015)
Boehringer Ingelheim Pharma
Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence.
J Med Chem 58: 577-87 (2015)
University Of Queensland
Probing the carboxyester side chain in controlled deactivation (-)-d(8)-tetrahydrocannabinols.
J Med Chem 58: 665-81 (2015)
Northeastern University
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
J Med Chem 58: 347-61 (2015)
Universit£
Identification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxia.
Bioorg Med Chem 22: 6796-805 (2015)
TBA
Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.
Bioorg Med Chem 22: 6768-75 (2015)
TBA
Design, synthesis, anticancer activity and docking studies of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives as mTOR inhibitors.
Bioorg Med Chem 22: 6746-54 (2015)
TBA
Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.
Bioorg Med Chem 22: 6735-45 (2015)
TBA
Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters.
Bioorg Med Chem 23: 222-30 (2014)
University Of Missouri
Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs.
Bioorg Med Chem 23: 149-59 (2014)
Peking University
Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.
Bioorg Med Chem 23: 231-40 (2014)
Kyung Hee University
Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.
Bioorg Med Chem Lett 24: 5695-8 (2014)
Roseman University Of Health Sciences
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett 24: 5683-7 (2014)
Genentech
Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3ß (GSK-3ß) with cellular activity of promoting glucose uptake.
Bioorg Med Chem Lett 24: 5639-43 (2014)
Fudan University
Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.
Bioorg Med Chem Lett 25: 367-71 (2014)
Hoffmann-La Roche
Novel azoles as potent and selective cannabinoid CB2 receptor agonists.
Bioorg Med Chem Lett 25: 88-91 (2015)
Ipsen Innovation
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett 25: 75-82 (2015)
Genentech
a-Ketoamino acid ester derivatives as promising MAO inhibitors.
Bioorg Med Chem Lett 25: 70-4 (2015)
King Saud University
Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Bioorg Med Chem Lett 25: 43-7 (2015)
Purdue Pharma
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett 24: 5630-4 (2014)
Amgen
Synthesis of the novel elemonic acid derivatives as Pin1 inhibitors.
Bioorg Med Chem Lett 24: 5612-5 (2014)
Shenyang Pharmaceutical University
The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain.
Bioorg Med Chem Lett 24: 5572-5 (2014)
Eli Lilly
ß-Keto andß-hydroxyphosphonate analogs of biotin-5'-AMP are inhibitors of holocarboxylase synthetase.
Bioorg Med Chem Lett 24: 5568-71 (2014)
University Of Nebraska-Lincoln
Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.
Bioorg Med Chem Lett 24: 5553-7 (2014)
Vanderbilt University
Discovery of novel Bcr-Abl inhibitors targeting myristoyl pocket and ATP site.
Bioorg Med Chem 22: 6876-84 (2014)
Xi'An Jiaotong University
Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of ?3?4 nicotinic acetylcholine receptor.
Bioorg Med Chem 22: 6846-56 (2014)
Medical University Of Lublin
Organocatalyzed solvent free an efficient novel synthesis of 2,4,5-trisubstituted imidazoles for a-glucosidase inhibition to treat diabetes.
Bioorg Chem 58: 65-71 (2015)
Comsats Institute Of Information Technology
Salicylanilide diethyl phosphates as cholinesterases inhibitors.
Bioorg Chem 58: 48-52 (2015)
Charles University In Prague
Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia.
Eur J Med Chem 89: 826-34 (2014)
Zhejiang University
Structural development studies of PPARs ligands based on tyrosine scaffold.
Eur J Med Chem 89: 817-25 (2014)
Universit£&Quot;G. D'Annunzio&Quot
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity froms2 receptor affinity in mixed P-gp/s2 receptor agents.
Eur J Med Chem 89: 691-700 (2014)
Universit£
Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.
Eur J Med Chem 89: 683-90 (2014)
University Of Granada
Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.
Eur J Med Chem 89: 628-37 (2014)
Shandong University
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump.
Eur J Med Chem 89: 606-15 (2014)
Universit£
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.
Eur J Med Chem 89: 597-605 (2014)
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors.
Eur J Med Chem 89: 581-96 (2014)
China Pharmaceutical University
Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones.
Eur J Med Chem 89: 549-60 (2014)
Egyptian Russian University
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy.
Eur J Med Chem 89: 503-23 (2014)
Goethe-University Frankfurt
A review on recent developments of indole-containing antiviral agents.
Eur J Med Chem 89: 421-41 (2014)
Central China Normal University
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.
Eur J Med Chem 89: 340-8 (2015)
Uit - The Arctic University Of Norway
In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor.
Eur J Med Chem 89: 310-9 (2014)
Fudan University
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.
Eur J Med Chem 89: 304-9 (2014)
Anadolu University
New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.
Eur J Med Chem 89: 296-303 (2014)
Tehran University Of Medical Sciences
Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands.
Eur J Med Chem 89: 198-206 (2014)
University Of Lille
Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study.
Eur J Med Chem 89: 189-97 (2014)
Academy Of Sciences Of The Czech Republic
Synthesis and structure--activity relationship of new cytotoxic agents targeting human glutathione-S-transferases.
Eur J Med Chem 89: 156-71 (2014)
Sapienza University Of Rome
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11ß-hydroxylase.
Eur J Med Chem 89: 106-14 (2014)
Universit£
In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors.
Eur J Med Chem 89: 98-105 (2014)
Universit£
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.
Eur J Med Chem 89: 32-41 (2014)
Universit£
Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies.
Eur J Med Chem 90: 436-47 (2015)
Pontif£Cia Universidade Cat£Lica Do Rio Grande Do Sul
Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.
Eur J Med Chem 90: 394-405 (2015)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry.
Eur J Med Chem 90: 379-93 (2015)
Dongguk University-Seoul
Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.
Eur J Med Chem 90: 258-66 (2015)
Universitat Rovira I Virgili
Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination.
Eur J Med Chem 90: 241-50 (2015)
Chinese Academy Of Sciences
Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors.
Eur J Med Chem 90: 195-208 (2015)
Korea University Of Science And Technology
Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents.
Eur J Med Chem 90: 170-83 (2015)
China Pharmaceutical University
Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: the advances continue.
Eur J Med Chem 90: 124-69 (2015)
University Of Nottingham
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4.
Eur J Med Chem 90: 21-32 (2015)
Medical University Of Warsaw
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.
Eur J Med Chem 90: 1-9 (2015)
Universit£
Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes.
Chem Biol 21: 1486-96 (2014)
Astrazeneca R&D
Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.
J Med Chem 57: 9958-70 (2014)
Astrazeneca
Rational design of novel CYP2A6 inhibitors.
Bioorg Med Chem 22: 6655-64 (2015)
University Of Eastern Finland
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.
Bioorg Med Chem 22: 6638-46 (2015)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
(R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling.
Bioorg Med Chem 22: 6684-93 (2014)
Chinese Academy Of Sciences
Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors.
Bioorg Med Chem 22: 6647-54 (2015)
TBA
Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core.
Bioorg Med Chem 22: 6625-37 (2015)
TBA
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.
Bioorg Med Chem 22: 6595-615 (2015)
TBA
Structural modifications of coumarin derivatives: Determination of antioxidant and lipoxygenase (LOX) inhibitory activity.
Bioorg Med Chem 22: 6586-94 (2015)
TBA
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Bioorg Med Chem 22: 6570-85 (2015)
TBA
Synthesis and biological evaluation of novel oxindole-based RTK inhibitors as anti-cancer agents.
Bioorg Med Chem 22: 6953-60 (2014)
Wenzhou Medical University
4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII.
Bioorg Med Chem 22: 6945-52 (2014)
Kurukshetra University
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bioorg Med Chem 22: 6933-44 (2014)
Medical University Of South Carolina
Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.
Bioorg Med Chem 22: 6899-907 (2014)
Astellas Pharma
An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition.
Bioorg Med Chem 22: 6552-63 (2015)
TBA
Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine.
Bioorg Med Chem 22: 6545-51 (2015)
TBA
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Bioorg Med Chem Lett 24: 5818-23 (2014)
Evotec
Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.
Bioorg Med Chem Lett 24: 5507-11 (2015)
Sapienza University Of Rome
Aurones as histone deacetylase inhibitors: identification of key features.
Bioorg Med Chem Lett 24: 5497-501 (2015)
University Of Geneva
2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: discovery of novel and potent CXCR2 antagonists.
Bioorg Med Chem Lett 24: 5493-6 (2015)
Glaxosmithkline
The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands.
Bioorg Med Chem Lett 24: 5489-92 (2015)
Janssen Research And Development
Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.
Bioorg Med Chem Lett 24: 5478-83 (2015)
Genomics Institute Of The Novartis Research Foundation
Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors.
Bioorg Med Chem Lett 24: 5473-7 (2015)
Institut Pasteur Korea
The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.
Bioorg Med Chem Lett 24: 5460-5 (2015)
Mitsubishi Tanabe Pharma
Discovery of potent iminoheterocycle BACE1 inhibitors.
Bioorg Med Chem Lett 24: 5455-9 (2015)
Merck Research Laboratories
Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity.
Bioorg Med Chem Lett 24: 5525-9 (2014)
University Of Siena
Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist.
Bioorg Med Chem Lett 24: 5364-8 (2014)
Raqualia Pharma
Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.
J Nat Prod 77: 2716-9 (2014)
Seoul National University
Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity.
J Med Chem 58: 433-42 (2015)
University Of South Carolina
Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery.
J Med Chem 58: 767-77 (2015)
Southmead Hospital
Anilinotriazoles as potent gamma secretase modulators.
Bioorg Med Chem Lett 24: 5805-13 (2014)
Janssen Pharmaceutica
Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).
Bioorg Med Chem Lett 24: 5801-4 (2014)
University Of Tennessee Health Science Center
Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.
Bioorg Med Chem Lett 24: 5450-4 (2015)
TBA
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Bioorg Med Chem Lett 24: 5435-8 (2015)
TBA
Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities.
Bioorg Med Chem Lett 24: 5787-91 (2014)
Wonkwang University
Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.
Bioorg Med Chem Lett 24: 5777-81 (2014)
Alexandru Ioan Cuza University
A reversed sulfonamide series of selective RORc inverse agonists.
Bioorg Med Chem Lett 24: 5769-76 (2014)
Argenta Discovery
Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIa.
Bioorg Med Chem Lett 24: 5762-8 (2014)
National Institute Of Chemistry
New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.
Bioorg Med Chem Lett 24: 5743-8 (2014)
Institute Of Pharmacology And Toxicology
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors.
Bioorg Med Chem Lett 24: 5721-6 (2014)
Bristol-Myers Squibb
A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.
Bioorg Med Chem Lett 24: 5716-20 (2014)
Virginia Commonwealth University
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1.
Bioorg Med Chem Lett 24: 5704-9 (2014)
Genentech
Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.
Bioorg Med Chem Lett 24: 5418-22 (2015)
TBA
Design, synthesis and anticancer evaluation of tetrahydro-ß-carboline-hydantoin hybrids.
Bioorg Med Chem Lett 24: 5413-7 (2015)
TBA
Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus.
Bioorg Med Chem Lett 24: 5395-8 (2015)
TBA
Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H2O2-induced cytotoxicity in PC12 cells.
Bioorg Med Chem Lett 24: 5385-9 (2015)
TBA
Design and synthesis of novel small molecule CCR2 antagonists: evaluation of 4-aminopiperidine derivatives.
Bioorg Med Chem Lett 24: 5377-80 (2015)
TBA
Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors.
Chem Biol Drug Des 85: 770-9 (2015)
Zhejiang University
¿F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.
Bioorg Med Chem Lett 24: 5840-4 (2014)
Wuhan University Of Science And Technology
A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.
Bioorg Med Chem Lett 24: 5836-9 (2014)
Takeda Pharmaceutical
Synthesis and SAR of thieno[3,2-b]pyridinyl urea derivatives as urotensin-II receptor antagonists.
Bioorg Med Chem Lett 24: 5832-5 (2014)
Korea Research Institute Of Chemical Technology
Amine-linked diquercitols as newa-glucosidase inhibitors.
Bioorg Med Chem Lett 24: 5530-3 (2014)
Chulalongkorn University
Synthesis of novel pyrazole?thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.
Bioorg Med Chem Lett 24: 5324-9 (2015)
Kle University
Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.
Bioorg Med Chem 22: 6515-22 (2015)
TBA
Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.
Bioorg Med Chem Lett 24: 5185-9 (2014)
King Saud University
Design, synthesis and molecular docking of substituted 3-hydrazinyl-3-oxo-propanamides as anti-tubercular agents.
Bioorg Med Chem Lett 24: 5181-4 (2014)
Csir-Central Drug Research Institute
Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation.
Bioorg Med Chem Lett 24: 5175-80 (2014)
Mitsubishi Tanabe Pharma
Bioactive compounds from the insect Aspongopus chinensis.
Bioorg Med Chem Lett 24: 5164-9 (2014)
Chinese Academy Of Sciences
Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation.
Bioorg Med Chem Lett 24: 5330-6 (2014)
Suez Canal University
Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.
J Med Chem 57: 9776-95 (2014)
Vertex Pharmaceuticals
Synthetic derivatives of aromatic abietane diterpenoids and their biological activities.
Eur J Med Chem 87: 834-42 (2014)
Universidad De Valencia
Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives possessing diaryl semicarbazone scaffolds as potent antitumor agents.
Eur J Med Chem 87: 782-93 (2014)
Shenyang Pharmaceutical University
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹8F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.
Bioorg Med Chem 23: 192-202 (2014)
University Medical Center Groningen
Discovery andw biological evaluation of novel 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety as c-Met kinase inhibitors.
Bioorg Med Chem 22: 6438-52 (2014)
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Synthesis and analysis of potentiala1,3-fucosyltransferase inhibitors.
Bioorg Med Chem 22: 6430-7 (2014)
Hamburg University
Inhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones.
Bioorg Med Chem 22: 6422-9 (2014)
University Of California
Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor.
Bioorg Med Chem 22: 6360-5 (2014)
University Of Arizona
Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.
Bioorg Med Chem 22: 6353-9 (2014)
Ecole Nationale Sup£Rieure De Chimie De Montpellier
Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease.
Bioorg Med Chem 22: 6344-52 (2014)
China Pharmaceutical University
Novel strategy to boost oral anticoagulant activity of blood coagulation enzyme inhibitors based on biotransformation into hydrophilic conjugates.
Bioorg Med Chem 22: 6324-32 (2014)
Astellas Pharma
Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.
Eur J Med Chem 90: 351-9 (2015)
Institute For Pharmaceutical Research Saarland (Hips)
Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).
Eur J Med Chem 90: 332-41 (2015)
Seoul National University
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.
Eur J Med Chem 90: 315-31 (2015)
University Of Nebraska
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: the role of a hydrogen-bond acceptor in long receptor residence times.
Bioorg Med Chem Lett 24: 5127-33 (2014)
RhôNe-Poulenc Rorer
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: lead optimization.
Bioorg Med Chem Lett 24: 5123-6 (2014)
RhôNe-Poulenc Rorer
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I.
Bioorg Med Chem Lett 24: 5118-22 (2014)
RhôNe-Poulenc Rorer
Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists.
Bioorg Med Chem Lett 24: 5111-7 (2014)
RhôNe-Poulenc Rorer
Sterol fatty acid esters from the mushroom Hericium erinaceum and their PPAR transactivational effects.
J Nat Prod 77: 2611-8 (2014)
Yeungnam University
Norbornane-based nucleoside and nucleotide analogues locked in North conformation.
Bioorg Med Chem 23: 184-91 (2014)
Academy Of Sciences Of The Czech Republic
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile.
Bioorg Med Chem 23: 212-21 (2014)
Jagiellonian University Medical College
New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists.
Bioorg Med Chem Lett 25: 20-4 (2014)
University Of Montpellier
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß.
Bioorg Med Chem Lett 25: 372-7 (2014)
Bristol-Myers Squibb
Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Bioorg Med Chem Lett 25: 384-8 (2014)
Vanderbilt University Medical Center
N-Aryl azacycles as novel sodium channel blockers.
Bioorg Med Chem Lett 25: 48-52 (2014)
Purdue Pharma
2-Substituted N¿-glutamylanilides as novel probes of ASCT2 with improved potency.
Bioorg Med Chem Lett 25: 113-6 (2014)
Vanderbilt University Institute Of Imaging Science (Vuiis)
Spirotetronate polyketides as leads in drug discovery.
J Nat Prod 78: 562-75 (2015)
University Of California San Diego
Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.
J Med Chem 58: 640-50 (2015)
Atat£Rk University
Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.
J Med Chem 57: 10304-13 (2014)
Sun Yat-Sen University
Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma.
J Med Chem 57: 10290-303 (2014)
Georgetown University Medical Center
Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.
J Med Chem 57: 10424-42 (2014)
Glaxosmithkline
Cytoprotective effects of hydrogen sulfide-releasing
Medchemcomm 5: 1577-1583 (2014)
Harvard Medical School
Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.
J Med Chem 58: 1012-8 (2015)
University Of California San Francisco
Synthesis and¿-opioid receptor activity of furan-substituted salvinorin A analogues.
J Med Chem 57: 10464-75 (2014)
The University Of Kansas
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).
J Med Chem 57: 10192-7 (2014)
Vanderbilt University School Of Medicine
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
J Med Chem 57: 10512-26 (2014)
Pfizer
In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.
J Med Chem 57: 9901-14 (2014)
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain.
J Med Chem 57: 10404-23 (2014)
Huazhong University Of Science And Technology
Antiadhesive properties of glycoclusters against Pseudomonas aeruginosa lung infection.
J Med Chem 57: 10275-89 (2014)
Universit£
Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.
ACS Med Chem Lett 5: 1202-1206 (2014)
University Of Toronto Mississauga
Synthesis of Novel Hybrids Inspired from Bromopyrrole Alkaloids Inhibiting MMP-2 and -12 as Antineoplastic Agents.
Chem Biol Drug Des 86: 210-22 (2015)
University Of Kwazulu-Nata
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
J Med Chem 57: 10455-63 (2014)
Laboratorio De Quimica Medica (Iqog, Csic)
Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis.
J Med Chem 57: 10366-82 (2014)
Universit£
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
J Med Chem 57: 9945-57 (2014)
Sapienza University Of Rome
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
J Med Chem 57: 10476-85 (2014)
Eli Lilly
Inhibitors of c-Jun N-terminal kinases: an update.
J Med Chem 58: 72-95 (2015)
Eberhard Karls Universit£T T£Bingen
Novel insights into structure and function of factor XIIIa-inhibitor tridegin.
J Med Chem 57: 10355-65 (2014)
University Of Bonn
Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials.
J Med Chem 57: 10557-63 (2014)
The University Of Sydney
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
J Med Chem 57: 9855-69 (2014)
University Of Dundee
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.
J Med Chem 57: 10112-29 (2014)
Array Biopharma
A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles.
J Med Chem 57: 9889-900 (2014)
Zhejiang University
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.
ACS Med Chem Lett 5: 1254-8 (2014)
Vanderbilt University School Of Medicine
Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors.
ACS Med Chem Lett 5: 1251-3 (2014)
Johns Hopkins University
Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts.
ACS Med Chem Lett 5: 1235-9 (2014)
Sumitomo Dainippon Pharma
Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist.
ACS Med Chem Lett 5: 1230-4 (2014)
Ono Pharmaceutical
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.
ACS Med Chem Lett 5: 1219-24 (2014)
Washington University
Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
ACS Med Chem Lett 5: 1213-8 (2014)
Astrazeneca
Structure Activity Relationships of ?v Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.
ACS Med Chem Lett 5: 1207-12 (2014)
University Of Nottingham
Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selectivea4ß2-nAChR Ligands.
ACS Med Chem Lett 5: 1196-201 (2014)
University Of Illinois At Chicago
1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.
ACS Med Chem Lett 5: 1190-5 (2014)
Glaxosmithkline
Pyrazolsulfonamide agonists of oxytocin receptor.
ACS Med Chem Lett 5: 1188-9 (2014)
Dart Neuroscience
Liver x receptor agonists for the treatment of coronary heart disease and other disorders.
ACS Med Chem Lett 5: 1186-7 (2014)
Therachem Research Medilab (India)
Inhibitors of Mutant IDH for the Treatment of Cancer.
ACS Med Chem Lett 5: 1184-5 (2014)
Therachem Research Medilab (India)
Neutrophil elastase inhibitors as potential anti-inflammatory therapies.
ACS Med Chem Lett 5: 1182-3 (2014)
Therachem Research Medilab (India)
Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme.
Biochemistry 53: 7445-58 (2014)
North Dakota State University
Targeting DNA methylation with small molecules: what's next?
J Med Chem 58: 2569-83 (2015)
Cnrs-Pierre Fabre
Selective inhibitors of protein methyltransferases.
J Med Chem 58: 1596-629 (2015)
Icahn School Of Medicine At Mount Sinai
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.
J Med Chem 57: 9915-32 (2014)
Bristol-Myers Squibb
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.
J Med Chem 58: 1038-52 (2015)
University Of Michigan Comprehensive Cancer Center And Departments Of Internal Medicine
Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection.
J Med Chem 57: 10130-43 (2014)
Boehringer Ingelheim (Canada)
Dicarba analogues ofa-conotoxin RgIA. Structure, stability, and activity at potential pain targets.
J Med Chem 57: 9933-44 (2014)
Monash University (Parkville Campus)
Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.
J Med Chem 57: 10013-30 (2014)
Translational Research Institute
Lead optimization and modulation of hERG activity in a series of aminooxazoline xantheneß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem 57: 9796-810 (2014)
Amgen
Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.
J Med Chem 57: 10198-204 (2014)
Universit£
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
J Med Chem 58: 41-71 (2015)
University Hospital Hradec Kralove
Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.
ACS Chem Biol 10: 421-32 (2015)
Vanderbilt University
Discovery heralds new approach to the treatment of cystic fibrosis.
J Med Chem 57: 9774-5 (2014)
Jl3Pharma
Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
J Med Chem 57: 10499-511 (2014)
Amgen
Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.
J Med Chem 57: 9832-43 (2014)
Chinese Academy Of Sciences
Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
J Med Chem 57: 9870-88 (2014)
University Of Gothenburg
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.
J Med Chem 57: 10176-91 (2014)
Genentech
Discovery of 2-(cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as a new series of potent phosphodiesterase 7 inhibitors.
J Med Chem 57: 9844-54 (2014)
Kyoto 607-8042
Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
Chembiochem 16: 59-63 (2015)
University Of Copenhagen
Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors.
J Med Chem 57: 10101-11 (2014)
Istituto Italiano Di Tecnologia
Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii.
Biochemistry 53: 7670-9 (2014)
Grand Valley State University
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem 57: 10044-57 (2014)
Galapagos
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.
J Med Chem 57: 9644-57 (2014)
Technical University Of Denmark
Quinone reductase 2 is an adventitious target of protein kinase CK2 inhibitors TBBz (TBI) and DMAT.
Biochemistry 54: 47-59 (2015)
University Of Western Ontario
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.
J Med Chem 57: 9983-94 (2014)
Universit£
Targeting aldose reductase for the treatment of diabetes complications and inflammatory diseases: new insights and future directions.
J Med Chem 58: 2047-67 (2015)
Universit£
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.
J Med Chem 57: 9539-53 (2014)
University Of Liege
Structures and bioactivities of dihydrochalcones from Metrodorea stipularis.
J Nat Prod 77: 2418-22 (2014)
Universidade Federal De S£O Carlos
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
J Med Chem 57: 9309-22 (2014)
Shandong University
Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).
J Med Chem 57: 10080-100 (2014)
Ku Leuven
SAR156497, an exquisitely selective inhibitor of aurora kinases.
J Med Chem 58: 362-75 (2015)
Sanofi
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
J Med Chem 57: 9512-21 (2014)
Chinese Academy Of Sciences
ß-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.
J Med Chem 57: 9370-82 (2014)
Trinity College
Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
J Med Chem 57: 9323-42 (2014)
Galapagos
Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.
J Med Chem 57: 9124-9 (2014)
Novartis Institutes For Biomedical Research
Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity.
J Med Chem 57: 9658-72 (2014)
De Montfort University
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
J Med Chem 57: 9447-62 (2014)
Domainex
Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3.
J Med Chem 57: 9396-408 (2014)
University Of Bergen
Inhibiting the deubiquitinating enzymes (DUBs).
J Med Chem 58: 1581-95 (2015)
Genentech
Inhibitors ofß-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).
J Med Chem 57: 9811-31 (2014)
Amgen
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.
Chem Biol Drug Des 86: 114-21 (2015)
Universidad De Santiago
Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.
J Med Chem 57: 9383-95 (2014)
Westf£Lische Wilhelms-Universit£T M£Nster
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
J Med Chem 57: 9435-46 (2014)
Vilnius University
A class of 4-sulfamoylphenyl-¿-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.
J Med Chem 57: 9673-86 (2014)
Universit£
Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.
J Med Chem 57: 9612-26 (2014)
Monash University
Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1a/malate dehydrogenase 2 inhibitors.
J Med Chem 57: 9522-38 (2014)
Dongguk University-Seoul
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
J Med Chem 58: 419-32 (2015)
Pfizer
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.
Chem Biol Drug Des 85: 756-69 (2015)
University Of California San Diego
Hybrids of phenylsulfonylfuroxan and coumarin as potent antitumor agents.
J Med Chem 57: 9343-56 (2014)
Fudan University
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett 5: 1082-7 (2014)
Merck Research Laboratories
1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.
J Med Chem 57: 9424-34 (2014)
University Of Cergy-Pontoise
Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.
Chem Biol Drug Des 85: 659-71 (2015)
China Pharmaceutical University
Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors.
Chem Biol Drug Des 85: 685-95 (2015)
Pontificia Universidad Catolica De Chile
Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.
J Med Chem 57: 9578-97 (2014)
Universit£
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J Med Chem 57: 9480-94 (2014)
University Of Illinois At Chicago
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.
J Med Chem 58: 401-18 (2015)
Genentech
Polyyne hybrid compounds from Notopterygium incisum with peroxisome proliferator-activated receptor gamma agonistic effects.
J Nat Prod 77: 2513-21 (2014)
Karl-Franzens-University Graz
Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.
J Med Chem 57: 9028-41 (2014)
Chinese Academy Of Sciences
Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease.
J Med Chem 58: 525-36 (2015)
Amgen
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
J Med Chem 57: 9598-611 (2014)
Translational Research Institute
Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).
J Med Chem 57: 9130-8 (2014)
Massachusetts General Hospital
Synthesis, Molecular Modeling, and Biological Evaluation of Novel 1, 3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents.
Chem Biol Drug Des 85: 729-42 (2015)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz
Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study.
Chem Biol Drug Des 85: 715-21 (2015)
Kannur University, Thalassery Campus
Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.
Bioorg Med Chem Lett 24: 5279-83 (2014)
School Of Life Science Nanjing University
Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2.
J Med Chem 57: 9473-9 (2014)
Max Planck Institute Of Psychiatry
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.
J Med Chem 57: 8792-816 (2014)
Vertex Pharmaceuticals
Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.
Bioorg Med Chem Lett 24: 5251-5 (2014)
Astrazeneca
Fragment-based screening of the bromodomain of ATAD2.
J Med Chem 57: 9687-92 (2014)
Vanderbilt University School Of Medicine
Biased multicomponent reactions to develop novel bromodomain inhibitors.
J Med Chem 57: 9019-27 (2014)
Dana-Farber Institute
Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin.
J Med Chem 57: 8928-35 (2014)
University Of Toyama
Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.
J Med Chem 57: 8817-26 (2014)
Merck Research Laboratories
Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Eur J Med Chem 87: 765-81 (2014)
Chinese Academy Of Sciences
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2.
J Med Chem 57: 8839-48 (2014)
University Of Cape Town
Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.
ACS Med Chem Lett 5: 1162-6 (2014)
Institutes Of Biomedicine And Health
Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
ACS Med Chem Lett 5: 1138-42 (2014)
Eli Lilly
Saralasin and Sarile Are AT2 Receptor Agonists.
ACS Med Chem Lett 5: 1129-32 (2014)
Universit£
Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.
ACS Med Chem Lett 5: 1119-23 (2014)
Dainippon Sumitomo Pharma
Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.
ACS Med Chem Lett 5: 1114-8 (2014)
Novartis Institutes For Biomedical Research
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
ACS Med Chem Lett 5: 1094-8 (2014)
Tokyo University Of Pharmacy And Life Sciences
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ACS Med Chem Lett 5: 1088-93 (2014)
Abbvie
3-Cyano-3-aza-ß-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins.
ACS Med Chem Lett 5: 1076-81 (2014)
University Of Bonn
Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif.
Bioorg Med Chem 22: 5766-75 (2014)
Shandong University
Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.
Bioorg Med Chem 22: 5860-70 (2014)
Institute Of Organic Synthesis
Synthesis and highly potent hypolipidemic activity of alpha-asarone- and fibrate-based 2-acyl and 2-alkyl phenols as HMG-CoA reductase inhibitors.
Bioorg Med Chem 22: 5871-82 (2014)
Instituto Polit£Cnico Nacional (Ipn)
Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.
J Med Chem 57: 9152-67 (2014)
Universit£
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
J Med Chem 57: 8503-16 (2014)
Novartis Institutes For Biomedical Research
Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.
Bioorg Med Chem 22: 5838-46 (2014)
Chinese Academy Of Sciences
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.
Bioorg Med Chem Lett 24: 5265-7 (2014)
Phenex Pharmaceuticals
A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses.
Eur J Med Chem 87: 677-702 (2014)
University Of Kwazulu-Natal
Implications of N-capped urea/thiourea and C-capped 3-(1-piperazinyl)-1,2-benzisothiazole with bridging Gly-Val/Phe-Gly-Val-Pro as therapeutic targets.
Eur J Med Chem 87: 657-61 (2014)
University Of Mysore
Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates.
Eur J Med Chem 87: 631-42 (2014)
Southeast University
¿-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents.
Bioorg Med Chem 22: 5776-82 (2014)
University Of Pune
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.
Bioorg Med Chem Lett 24: 5304-9 (2014)
University Of Camerino
Vanillin-derived antiproliferative compounds influence Plk1 activity.
Bioorg Med Chem Lett 24: 5063-9 (2014)
Johann-Wolfgang-Goethe University Of Frankfurt
Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5?-androstane-3?,17?-diol derivatives.
Bioorg Med Chem 22: 5847-59 (2014)
Universit£
Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin converting enzyme (ACE) inhibitors.
Bioorg Med Chem 22: 5824-30 (2014)
Csir-Indian Institute Of Chemical Technology
Scaffold hopping approach on the route to selective tankyrase inhibitors.
Eur J Med Chem 87: 611-23 (2014)
University Of Perugia
Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
J Med Chem 57: 9168-83 (2014)
Monash University
Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships.
Chem Biol Drug Des 85: 574-85 (2015)
Konkuk University
Structure-activity relationship of highly potent galactonoamidine inhibitors toward ?-galactosidase (Aspergillus oryzae).
J Med Chem 57: 8999-9009 (2014)
University Of Arkansas
Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases.
Bioorg Med Chem Lett 24: 5310-4 (2014)
Heidelberg University
n-Alkylboronic acid inhibitors reveal determinants of ligand specificity in the quorum-quenching and siderophore biosynthetic enzyme PvdQ.
Biochemistry 53: 6679-86 (2014)
The University Of Texas
Structure-guided design and development of novel benzimidazole class of compounds targeting DNA gyraseB enzyme of Staphylococcus aureus.
Bioorg Med Chem 22: 5970-87 (2014)
Birla Institute Of Technology & Science-Pilani
Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Bioorg Med Chem 22: 5831-7 (2014)
Johns Hopkins University
Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase.
Bioorg Med Chem 22: 6193-200 (2014)
Institute For Theoretical Medicine
Human alpha1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines.
Bioorg Med Chem 22: 5910-6 (2014)
Unsw Australia
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
Bioorg Med Chem Lett 24: 5081-5 (2014)
University Of Pittsburgh
Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.
Bioorg Med Chem Lett 24: 4958-62 (2014)
Merck Research Laboratory
An update on therapeutic opportunities offered by cancer glycolytic metabolism.
Bioorg Med Chem Lett 24: 4915-25 (2014)
Universit£
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.
J Med Chem 57: 8984-98 (2014)
Astrazeneca
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization.
J Med Chem 57: 9078-95 (2014)
Astrazeneca
Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor.
Bioorg Med Chem 22: 5902-9 (2014)
Kyushu University
Design, synthesis, and structure-activity relationship of novel opioid¿ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.
Bioorg Med Chem Lett 24: 4980-3 (2014)
Kitasato University
Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.
Chem Biol Drug Des 85: 549-64 (2015)
Northeastern University
Design and optimization of novel 4-(2-fluorophenoxy)quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors.
Eur J Med Chem 87: 508-18 (2014)
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Bioorg Med Chem 22: 6694-705 (2014)
University Of Eastern Finland
Design, synthesis and evaluation of novel tacrine-(ß-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem 22: 6089-104 (2014)
China Pharmaceutical University
Development of benzo[d]oxazol-2(3H)-ones derivatives as novel inhibitors of Mycobacterium tuberculosis InhA.
Bioorg Med Chem 22: 6134-45 (2014)
Birla Institute Of Technology
Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase.
Bioorg Med Chem 22: 5988-6003 (2014)
University Of Latvia
Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.
Bioorg Med Chem 22: 5961-9 (2014)
University Of Kansas
Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors.
Bioorg Med Chem Lett 24: 5093-7 (2014)
Sungkyunkwan University
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Eur J Med Chem 87: 429-39 (2014)
Sun Yat-Sen University
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters.
Eur J Med Chem 87: 398-412 (2014)
Universit£
Fluorinated analogues of marsanidine, a highly ?2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities.
Eur J Med Chem 87: 386-97 (2014)
Medical University Of Gdansk
Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.
Bioorg Med Chem 22: 6026-38 (2014)
Astellas Pharma
DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development.
J Med Chem 57: 10241-56 (2014)
Central University Of Punjab
Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.
Bioorg Med Chem Lett 24: 5022-9 (2014)
Bristol-Myers Squibb Research & Development
Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome.
Bioorg Med Chem 22: 6047-52 (2014)
Chungnam National University
Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.
Eur J Med Chem 87: 346-63 (2014)
Shandong University
Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.
Eur J Med Chem 87: 336-45 (2014)
University Of Coimbra
Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1).
J Med Chem 57: 9065-77 (2014)
Universit£
Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
J Med Chem 57: 8340-57 (2014)
University Of Minnesota
CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.
J Med Chem 57: 8777-91 (2014)
Universit£
Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.
J Med Chem 58: 265-77 (2015)
Bmssi Umr 5086 Cnrs/Universit£
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
J Med Chem 57: 8249-67 (2014)
Astrazeneca
Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.
J Med Chem 57: 8307-18 (2014)
Baylor College Of Medicine
Discovery of 4-aminoquinazoline--urea derivatives as Aurora kinase inhibitors with antiproliferative activity.
Bioorg Med Chem 22: 5813-23 (2014)
Southeast University
Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.
J Med Chem 57: 8903-27 (2014)
The University Of Mississippi
How aß-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
J Med Chem 57: 8563-75 (2014)
Consiglio Nazionale Delle Ricerche
Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators.
J Med Chem 57: 9105-23 (2014)
University Of Sevilla
Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAF(V600E) inhibitors.
Bioorg Med Chem 22: 6201-8 (2014)
Nanjing University
Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.
Bioorg Med Chem 22: 5883-90 (2014)
Universit£
Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists.
Bioorg Med Chem 22: 6071-88 (2014)
Eisai
Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.
Bioorg Med Chem Lett 24: 5059-62 (2014)
University Of British Columbia
Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors for the treatment of metabolic disorders.
Bioorg Med Chem Lett 24: 5045-9 (2014)
Bristol-Myers Squibb
Ejection of structural zinc leads to inhibition of¿-butyrobetaine hydroxylase.
Bioorg Med Chem Lett 24: 4954-7 (2014)
University Of Oxford
Potent cholesteryl ester transfer protein inhibitors of reduced lipophilicity: 1,1'-spiro-substituted hexahydrofuroquinoline derivatives.
J Med Chem 57: 8766-76 (2014)
Boehringer Ingelheim Pharma
Targeting matrix metalloproteinases: exploring the dynamics of the s1' pocket in the design of selective, small molecule inhibitors.
J Med Chem 57: 10205-19 (2014)
Universidad Ceu San Pablo
Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.
J Med Chem 57: 8590-607 (2014)
Centro De Investigaciones Biol�Gicas (Csic)
Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.
J Med Chem 57: 8886-902 (2014)
Takeda Pharmaceutical
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
Eur J Med Chem 87: 316-27 (2014)
Universidad Aut£Noma Del Estado De Morelos
Indoleamine 2,3-dioxygenase inhibitors: potential treatment for cancer, sepsis, and more.
ACS Med Chem Lett 5: 958-60 (2014)
Therachem Research Medilab (India)
Modulators of GPR40 as Treatment for Diabetes.
ACS Med Chem Lett 5: 954-5 (2014)
Therachem Research Medilab (India)
Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas.
Bioorg Med Chem Lett 24: 5102-6 (2014)
Northwest A&F University
Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping.
Bioorg Med Chem 22: 6256-69 (2014)
Astrazeneca
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor.
Bioorg Med Chem 22: 6117-23 (2014)
East China Normal University
2-(2-Bromophenyl)-formononetin and 2-heptyl-formononetin are PPAR¿ partial agonists and reduce lipid accumulation in 3T3-L1 adipocytes.
Bioorg Med Chem 22: 6105-11 (2014)
University Of Copenhagen
Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines.
Bioorg Med Chem Lett 24: 4969-75 (2014)
Hoffmann-La Roche
Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities.
Eur J Med Chem 87: 306-15 (2014)
Shenyang Pharmaceutical University
Pyrazole derivatives as potent inhibitors of c-Jun N-terminal kinase: synthesis and SAR studies.
Bioorg Med Chem 22: 6209-19 (2014)
Kakatiya University
Effect of dehydroepiandrosterone derivatives on the activity of 5a-reductase isoenzymes and on cancer cell line PC-3.
Bioorg Med Chem 22: 6233-41 (2014)
National University Of Mexico
Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.
Bioorg Med Chem 22: 6146-55 (2014)
The Walter And Eliza Hall Institute Of Medical Research
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands ata<alpha>1 and 5-HT1A receptors.
Eur J Med Chem 87: 248-66 (2014)
Universit£
Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.
Bioorg Med Chem 22: 6124-33 (2014)
Hu'Nan University
Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E(2) synthase-1 inhibitors.
Bioorg Med Chem Lett 24: 4838-44 (2014)
Glenmark Pharmaceuticals
Potent heterocyclic ligands for human complement c3a receptor.
J Med Chem 57: 8459-70 (2014)
The University Of Queensland
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-ß aggregation and to exert anticholinesterase and antioxidant effects.
J Med Chem 57: 8576-89 (2014)
Alma Mater Studiorum-University Of Bologna
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.
J Med Chem 57: 8268-79 (2014)
Academy Of Sciences Of The Czech Republic
Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17ß-hydroxysteroid dehydrogenase type 2 inhibitors.
Eur J Med Chem 87: 203-19 (2014)
Saarland University
Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.
Bioorg Med Chem 22: 6163-73 (2014)
Quaid-I-Azam University
Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.
Eur J Med Chem 87: 186-96 (2014)
King Saud University
Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-¿ agonists.
Eur J Med Chem 87: 175-85 (2014)
Jamia Hamdard (Hamdard University)
Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase.
J Med Chem 57: 8445-58 (2014)
Shandong University
Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.
J Nat Prod 77: 2170-81 (2014)
University Of Toronto
Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.
J Med Chem 58: 278-93 (2015)
Astrazeneca
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist.
J Med Chem 57: 8035-55 (2014)
Goethe-University Frankfurt
Optimized protein kinase C¿ (PKC¿) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.
J Med Chem 58: 333-46 (2015)
Abbvie Bioresearch Center
Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.
J Med Chem 57: 8378-97 (2014)
Syntrix Biosystems
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.
J Med Chem 57: 8827-38 (2014)
Heinrich Heine Universit£T
Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.
J Med Chem 57: 8635-45 (2014)
Griffith University
Development ofaGlcN(1¿1)aMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists.
J Med Chem 57: 8056-71 (2014)
University Of Natural Resources And Life Sciences
Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.
J Med Chem 57: 8622-34 (2014)
The State University Of New York
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
J Med Chem 57: 9096-104 (2014)
Leiden University
The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
J Med Chem 57: 8111-31 (2014)
Glaxosmithkline
Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors.
Bioorg Med Chem Lett 24: 5037-40 (2014)
Universit£
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.
Bioorg Med Chem Lett 24: 4895-8 (2014)
Kitasato University
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Bioorg Med Chem Lett 24: 4884-90 (2014)
Merck Research Laboratories
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Bioorg Med Chem Lett 24: 4812-7 (2014)
Novartis Horsham Research Centre
Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.
J Med Chem 57: 8477-95 (2014)
University Of Naples&Quot;Federico Ii&Quot
Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation.
J Med Chem 57: 8646-51 (2014)
Kyoto University
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis,ß-glucuronidase inhibition activity, crystal structure, and POM analyses.
Bioorg Med Chem 22: 6715-25 (2014)
King Saud University
Development of a novel class of mitochondrial ubiquinol-cytochrome c reductase binding protein (UQCRB) modulators as promising antiangiogenic leads.
J Med Chem 57: 7990-8 (2014)
Yonsei University
Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.
Bioorg Med Chem Lett 24: 4807-11 (2014)
Boehringer Ingelheim Pharmaceuticals
The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor.
Bioorg Med Chem Lett 24: 4871-5 (2014)
Novartis Institutes For Biomedical Research
The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.
Bioorg Med Chem Lett 24: 4826-30 (2014)
Georgia Institute Of Technology
Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization.
Eur J Med Chem 87: 52-62 (2014)
Shandong University
Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation.
Eur J Med Chem 87: 39-51 (2014)
Cardiff University
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
J Med Chem 57: 8664-70 (2014)
Imperial College
Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.
J Med Chem 57: 8540-62 (2014)
University Of Rochester Medical Center
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
J Med Chem 57: 8398-420 (2014)
University Of Hawaii At Hilo
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.
J Med Chem 57: 8026-34 (2014)
Roche Pharmaceutical Research And Early Development
Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter.
J Med Chem 57: 8152-66 (2014)
Duquesne University
ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.
J Med Chem 57: 8358-77 (2014)
R&D Sigma-Tau Industrie Farmaceutiche Riunite
Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure.
Eur J Med Chem 86: 724-39 (2014)
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.
Eur J Med Chem 86: 714-23 (2014)
The University Of Arizona
Efficient synthesis of hexahydroindenopyridines and their potential as melatoninergic ligands.
Eur J Med Chem 86: 700-9 (2014)
Universidad De Valencia
Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.
J Med Chem 57: 8099-110 (2014)
National Center For Advancing Translational Sciences
1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and ß-amyloid aggregation inhibitors: biological evaluation and in silico study.
Chem Biol Drug Des 85: 494-503 (2015)
Mazandaran University Of Medical Sciences
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
J Med Chem 57: 8167-79 (2014)
University Of Ljubljana
Cyclic adenosine 5'-diphosphate ribose analogs without a"southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
J Med Chem 57: 8517-29 (2014)
University Of Bath
Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase.
Medchemcomm 379-384 (2012)
Chinese Academy Of Sciences
Reversible Covalent Inhibition of eEF-2K by Carbonitriles.
Chembiochem 15: 2435-42 (2014)
The University Of Texas At Austin
Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives.
Bioorg Chem 57: 57-64 (2014)
Central University Of Punjab
Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
J Nat Prod 77: 2054-9 (2014)
Zhejiang University
Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity.
ACS Med Chem Lett 5: 1060-4 (2014)
Vanderbilt University
Acyclic tethers mimicking subunits of polysaccharide ligands: selectin antagonists.
ACS Med Chem Lett 5: 1054-9 (2014)
Institut De Recherches Cliniques De Montr£Al (Ircm)
Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target Engagement.
ACS Med Chem Lett 5: 1049-53 (2014)
Janssen Pharmaceutica
Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.
ACS Med Chem Lett 5: 1043-8 (2014)
National Institute Of Diabetes And Digestive And Kidney Diseases
C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.
ACS Med Chem Lett 5: 1037-42 (2014)
Heidelberg University
Novel cyclic biphalin analogue with improved antinociceptive properties.
ACS Med Chem Lett 5: 1032-6 (2014)
Universit£
Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.
ACS Med Chem Lett 5: 1015-20 (2014)
University Of Pennsylvania
Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors.
ACS Med Chem Lett 5: 1010-4 (2014)
Gedeon Richter
2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis.
ACS Med Chem Lett 5: 1005-9 (2014)
Astrazeneca
Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-a-Oxyazetidine.
ACS Med Chem Lett 5: 999-1004 (2014)
Korea University
Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.
ACS Med Chem Lett 5: 993-8 (2014)
Roche Innovation Center Shanghai
Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.
ACS Med Chem Lett 5: 989-92 (2014)
Novartis Institutes For Biomedical Research
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
ACS Med Chem Lett 5: 983-8 (2014)
Minia University
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.
ACS Med Chem Lett 5: 973-8 (2014)
University Of Bologna
Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor.
ACS Med Chem Lett 5: 968-72 (2014)
University Of Trieste
Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4.
ACS Med Chem Lett 5: 963-7 (2014)
Saarland University
Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.
Bioorg Med Chem Lett 24: 4630-7 (2014)
Technische Universit£T Darmstadt
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.
Bioorg Med Chem Lett 24: 4638-42 (2014)
National Institute Of Pharmaceutical Education And Research
Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.
Eur J Med Chem 86: 639-52 (2014)
Chinese Academy Of Sciences
Development of 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis.
Eur J Med Chem 86: 613-27 (2014)
Birla Institute Of Technology
Anti-tyrosinase, antioxidant, and antibacterial activities of novel 5-hydroxy-4-acetyl-2,3-dihydronaphtho[1,2-b]furans.
Eur J Med Chem 86: 605-12 (2014)
Yeungnam University
Studies on molecular properties prediction and histamine H3 receptor affinities of novel ligands with uracil-based motifs.
Eur J Med Chem 86: 578-88 (2014)
University Of Catania
Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus.
Eur J Med Chem 88: 66-73 (2014)
Stony Brook University
Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes.
Chem Biol Drug Des 85: 439-46 (2015)
Csir-Central Drug Research Institute
Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.
J Med Chem 57: 9740-63 (2014)
University Of Groningen
Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.
J Med Chem 57: 7731-57 (2014)
Albany Molecular Research
Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.
J Med Chem 57: 7499-508 (2014)
Departments Of Discovery Chemistry, Metabolic Diseases, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, Exploratory Clinical And Translational Research, And Pharmaceutical Candi
Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B.
Bioorg Med Chem Lett 24: 4749-53 (2014)
Hunan University
Discovery of (E)-5-(benzylideneamino)-1H-benzo[d]imidazol-2(3H)-one derivatives as inhibitors for PTK6.
Bioorg Med Chem Lett 24: 4659-63 (2014)
Yonsei University
Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: synthesis, cytostatic and antioxidative activity.
Eur J Med Chem 86: 502-14 (2014)
University Of Zagreb
Novel sulfonyl(thio)urea derivatives act efficiently both as insulin secretagogues and as insulinomimetic compounds.
Eur J Med Chem 86: 491-501 (2014)
Universidade Federal De Santa Catarina
Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806.
Eur J Med Chem 86: 481-90 (2014)
Shandong University
Discovery of 2-pyridylureas as glucokinase activators.
J Med Chem 57: 8180-6 (2014)
Array Biopharma
Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Eur J Med Chem 86: 438-48 (2014)
Shanghai Institute Of Materia Medica (Simm)
Exploring human parainfluenza virus type-1 hemagglutinin-neuraminidase as a target for inhibitor discovery.
J Med Chem 57: 7613-23 (2014)
Griffith University
The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis.
J Med Chem 57: 7536-49 (2014)
University Of Dundee
A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics
Nat Chem Biol 10: 853-860 (2014)
George Washington University
Quinazoline-sulfonamides with potent inhibitory activity against thea-carbonic anhydrase from Vibrio cholerae.
Bioorg Med Chem 22: 5133-40 (2014)
Salman Bin Abdulaziz University
Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.
Eur J Med Chem 85: 818-29 (2014)
University Of Mississippi
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Bioorg Med Chem Lett 24: 4714-23 (2014)
Genentech
Alpha-ethyltryptamines as dual dopamine-serotonin releasers.
Bioorg Med Chem Lett 24: 4754-8 (2014)
Research Triangle Institute
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1¿ binding site.
Bioorg Med Chem 22: 5487-505 (2014)
Takeda Pharmaceutical
Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.
J Med Chem 57: 8140-51 (2014)
University Of Athens
Semisynthetic analogues of toxiferine I and their pharmacological properties ata7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.
J Nat Prod 77: 2006-13 (2014)
The German University In Cairo
Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1d ande with nanomolar inhibitory activity on cancer cell proliferation.
J Med Chem 57: 7933-46 (2014)
Ulm University Hospital
Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties.
Bioorg Med Chem Lett 24: 4743-8 (2014)
Pt. Ravishankar Shukla University
Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.
Bioorg Med Chem 22: 5141-54 (2014)
Eastern Mediterranean University
Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.
Bioorg Med Chem 22: 5428-45 (2014)
Takeda Pharmaceutical
Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase.
J Med Chem 57: 7798-803 (2014)
Universit£
Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3.
Bioorg Med Chem 22: 5220-33 (2014)
Gifu Pharmaceutical University
Pyrazolone-quinazolone hybrids: a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors.
Bioorg Med Chem 22: 5194-211 (2014)
Central China Normal University
Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents.
Bioorg Med Chem Lett 24: 4768-72 (2014)
Shanghai Huilun Life Sciences & Technology
Synthesis and evaluation of arylpiperazines derivatives of 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR ligands.
Bioorg Med Chem Lett 24: 4759-62 (2014)
Stony Brook University
N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H.
Bioorg Chem 57: 43-50 (2014)
Kurukshetra University
Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.
J Med Chem 57: 7673-86 (2014)
Universit£
2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.
J Med Chem 57: 7485-98 (2014)
Vanderbilt University Medical Center
Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity.
J Med Chem 58: 237-51 (2015)
University Of Paris
Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.
J Med Chem 57: 7770-91 (2014)
Chinese Academy Of Sciences
Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach.
J Med Chem 57: 7624-43 (2014)
Ku Leuven
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.
Bioorg Med Chem Lett 24: 4708-13 (2014)
Northwest Agriculture & Forestry University
The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.
Bioorg Med Chem Lett 24: 4397-401 (2014)
Xenon Pharmaceuticals
The discovery of potent glycine transporter type-2 inhibitors: design and synthesis of phenoxymethylbenzamide derivatives.
Bioorg Med Chem Lett 24: 4603-6 (2014)
Toray Industries
Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.
Bioorg Med Chem Lett 24: 4729-34 (2014)
Csir-Indian Institute Of Integrative Medicine
Potent 11ß-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing.
J Med Chem 57: 7811-7 (2014)
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
Eur J Med Chem 86: 352-63 (2014)
European Institute Of Oncology
Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents.
Bioorg Chem 57: 30-42 (2014)
Shenyang Pharmaceutical University
ASK1 pharmacophore model derived from diverse classes of inhibitors.
Bioorg Med Chem Lett 24: 4418-23 (2014)
Nas Of Ukraine
Design, synthesis and molecular modeling of biquinoline-pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors.
Bioorg Med Chem Lett 24: 4472-6 (2014)
Nanjing University
Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites.
Bioorg Med Chem 22: 5368-77 (2014)
University Of Copenhagen
Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents.
Eur J Med Chem 86: 257-69 (2014)
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University) Ministry Of Education
Anion inhibition study of theß-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.
Bioorg Med Chem Lett 24: 4402-6 (2014)
Universit£
Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.
Bioorg Med Chem Lett 24: 4482-5 (2014)
University Of Monastir
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the¿-carbonic anhydrases.
Bioorg Med Chem Lett 24: 4389-96 (2014)
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr
Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax.
J Med Chem 57: 7644-62 (2014)
The Walter And Eliza Hall Institute Of Medical Research
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
J Med Chem 57: 8657-63 (2014)
University Of Dundee
Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.
Eur J Med Chem 86: 242-56 (2014)
Shanghai Institute Of Materia Medica
Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors.
Eur J Med Chem 86: 219-34 (2014)
Shanghai Institute Of Pharmaceutical Industry
Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).
J Med Chem 57: 7687-701 (2014)
University Of Naples&Quot;Federico Ii&Quot
Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.
J Med Chem 57: 7792-7 (2014)
The Ohio State University
Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1).
J Med Chem 57: 7758-69 (2014)
Research Triangle Institute
Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.
Eur J Med Chem 88: 89-100 (2014)
European Molecular Biology Laboratory
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
J Med Chem 57: 7472-7 (2014)
Research Triangle Institute
Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.
J Med Chem 57: 7342-54 (2014)
Beijing Institute Of Pharmacology & Toxicology
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents withß-amyloid and tau anti-aggregating properties.
Bioorg Med Chem 22: 5298-307 (2014)
Universitat De Barcelona
Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.
Bioorg Med Chem 22: 5308-14 (2014)
Universidad Nacional De La Plata
Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.
Bioorg Med Chem 22: 5392-409 (2014)
Astrazeneca
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg Med Chem Lett 24: 4444-9 (2014)
Idenix Pharmaceuticals
Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists.
Bioorg Med Chem Lett 24: 4450-4 (2014)
Hoffmann-La Roche
Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase (cytochrome P450 19A1).
Bioorg Med Chem Lett 24: 4586-9 (2014)
Mcmaster University
20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng.
Bioorg Med Chem Lett 24: 4407-9 (2014)
Kyushu University
Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo.
J Med Chem 57: 7523-35 (2014)
University Of Athens
Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors.
Bioorg Med Chem 22: 5354-67 (2014)
Goethe University
Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors.
Bioorg Med Chem 22: 5290-7 (2014)
Shandong University
Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.
Bioorg Med Chem 22: 5446-53 (2014)
Shandong University
Novel Roflumilast analogs as soft PDE4 inhibitors.
Bioorg Med Chem Lett 24: 4594-7 (2014)
Amakem
Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.
Bioorg Med Chem Lett 24: 4504-10 (2014)
Northwestern University
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists.
Bioorg Med Chem Lett 24: 4598-602 (2014)
University Of Oslo
Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation.
J Med Chem 57: 7702-15 (2014)
Cardiff University
Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer.
J Med Chem 57: 7577-89 (2014)
Hutchison Medipharma
Discovery of novel highly potent hepatitis C virus NS5A inhibitor (AV4025).
J Med Chem 57: 7716-30 (2014)
Alla Chem
Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
J Med Chem 57: 7804-10 (2014)
Vanderbilt University Medical Center
Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.
ACS Med Chem Lett 5: 927-30 (2014)
Universit£
Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes.
ACS Med Chem Lett 5: 921-6 (2014)
Xuanzhu Pharma
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.
ACS Med Chem Lett 5: 905-10 (2014)
University Of Florida
Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor.
ACS Med Chem Lett 5: 889-93 (2014)
Hokkaido University
Synthesis and Pharmacology of a Novel¿ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.
ACS Med Chem Lett 5: 868-72 (2014)
Kitasato University
Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol.
ACS Med Chem Lett 5: 857-62 (2014)
Pharmacokinetics
Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists.
ACS Med Chem Lett 5: 851-6 (2014)
Pharmacokinetics
Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.
ACS Med Chem Lett 5: 846-50 (2014)
Brandeis University
ROR¿t Modulators Are Potentially Useful for the Treatment of the Immune-Mediated Inflammatory Diseases.
ACS Med Chem Lett 5: 844-5 (2014)
Therachem Research Medilab (India)
MoGAT-2 Inhibitors May Provide Effective Treatment for Hypertriglyceridemia.
ACS Med Chem Lett 5: 840-1 (2014)
Therachem Research Medilab (India)
Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.
Eur J Med Chem 86: 122-32 (2014)
Dokki
Kaempferol, a potential cytostatic and cure for inflammatory disorders.
Eur J Med Chem 86: 103-12 (2014)
Npo-International Laboratory Of Biochemistry
Sulfamates of methyl triterpenoates are effective and competitive inhibitors of carbonic anhydrase II.
Eur J Med Chem 86: 95-102 (2014)
Martin-Luther-Universit£T Halle-Wittenberg
Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the ?4?2 and ?6/?3?2?3 nicotinic acetylcholine receptors (nAChRs).
Eur J Med Chem 86: 60-74 (2014)
Targacept
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
Eur J Med Chem 86: 48-59 (2014)
Universidade Federal De Pernambuco
Synthesis, biological evaluation, and molecular docking studies of xanthone sulfonamides as ACAT inhibitors.
Chem Biol Drug Des 85: 394-403 (2015)
Second Military Medical University
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
ACS Chem Biol 9: 2526-34 (2014)
Monash University
Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.
J Med Chem 57: 7435-49 (2014)
Mcgill University
Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors.
J Med Chem 57: 8718-28 (2014)
Montclair State University
Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors.
Bioorg Med Chem 22: 5513-29 (2014)
Eisai
Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives.
Bioorg Med Chem Lett 24: 4538-41 (2014)
Pkucare Pharmaceutical R & D Center
Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors.
Bioorg Med Chem Lett 24: 4557-67 (2014)
King Saud University
Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III.
Bioorg Med Chem Lett 24: 4533-7 (2014)
Riken-Max Planck Joint Research Center For Systems Chemical Biology
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg Med Chem Lett 24: 4546-52 (2014)
Genentech
Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity.
Eur J Med Chem 86: 31-8 (2014)
University Of Leeds
Tricyclic pyrazoles part 7. Discovery of potent and selective dihydrothienocyclopentapyrazole derived CB2 ligands.
Eur J Med Chem 85: 747-57 (2014)
Universit£
Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
J Med Chem 57: 7367-81 (2014)
Research Triangle Institute
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors.
Bioorg Med Chem 22: 5466-75 (2014)
National Institute Of Pharmaceutical Education And Research (Niper)
Substrate derived peptidica-ketoamides as inhibitors of the malarial protease PfSUB1.
Bioorg Med Chem Lett 24: 4486-9 (2014)
Latvian Institute Of Organic Synthesis
Design, synthesis, biological evaluation of substituted benzofurans as DNA gyraseB inhibitors of Mycobacterium tuberculosis.
Bioorg Med Chem 22: 4924-34 (2014)
Institute Of Technology & Science-Pilani
'Carba'-carfentanil (trans isomer): aµ opioid receptor (MOR) partial agonist with a distinct binding mode.
Bioorg Med Chem 22: 4581-6 (2014)
Clinical Research Institute Of Montreal
Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: theß-class (PgiCAb) versus the¿-class (PgiCA) enzymes.
Bioorg Med Chem 22: 4537-43 (2014)
Istituto Di Biochimica Delle Proteine-Cnr
Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.
Eur J Med Chem 85: 716-26 (2014)
Universit£
Present status of quinoxaline motifs: excellent pathfinders in therapeutic medicine.
Eur J Med Chem 85: 688-715 (2014)
Covenant University
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.
Bioorg Med Chem 22: 4658-66 (2014)
University Of Perugia
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
Bioorg Med Chem 22: 4566-71 (2014)
University Of Warwick
Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases.
Bioorg Med Chem 22: 4602-8 (2014)
University Of North Florida
Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.
Bioorg Med Chem 22: 4587-96 (2014)
Yonsei University
Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors.
Bioorg Med Chem Lett 24: 4084-9 (2014)
Northeastern University
Novel thienopyrimidinones as mGluR1 antagonists.
Eur J Med Chem 85: 629-37 (2014)
Yonsei University
Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.
Eur J Med Chem 85: 605-14 (2014)
Russian Academy Of Sciences
Some molecular targets for antihyperlipidemic drug research.
Eur J Med Chem 85: 535-68 (2014)
Banasthali University
Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.
Bioorg Med Chem Lett 24: 4171-5 (2014)
University Of Pennsylvania
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.
Bioorg Med Chem Lett 24: 4158-61 (2014)
Yale University
Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists.
Bioorg Med Chem Lett 24: 4266-70 (2014)
Dainippon Sumitomo Pharma
Synthesis, biological evaluation, and molecular modeling of new 3-(cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors.
J Med Chem 57: 7061-72 (2014)
University Of Genoa
Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.
J Med Chem 57: 7042-60 (2014)
Southern Research Institute
Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication
ACS Chem Biol 9: 2393-2403 (2014)
University Of Wisconsin-Milwaukee
4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 24: 4080-3 (2014)
Korea Research Institute Of Chemical Technology
Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.
Bioorg Med Chem Lett 24: 4308-11 (2014)
Sanford-Burnham Medical Research Institute
Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.
Bioorg Med Chem Lett 24: 4125-8 (2014)
Liaoning Normal University
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
Cancer Discov 4: 1310-25 (2014)
Fred Hutchinson Cancer Research Center
Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases.
J Med Chem 58: 2-29 (2015)
University Of Nebraska Medical Center
3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration.
J Med Chem 57: 7396-411 (2014)
Novartis Institutes For Biomedical Research
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.
J Med Chem 57: 6965-72 (2014)
University Of Texas Southwestern Medical Center
Exploring the influence of the protein environment on metal-binding pharmacophores.
J Med Chem 57: 7126-35 (2014)
University Of California
Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.
Bioorg Med Chem Lett 24: 4110-3 (2014)
Merck Research Laboratory
Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y(12) antagonists for inhibition of platelet aggregation.
Bioorg Med Chem Lett 24: 4323-31 (2014)
Actelion Pharmaceuticals
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Bioorg Med Chem Lett 24: 4132-40 (2014)
Pfizer
Synthesis and bioevaluation of 2-phenyl-4-methyl-1,3-selenazole-5-carboxylic acids as potent xanthine oxidase inhibitors.
Eur J Med Chem 85: 508-16 (2014)
Shenyang Pharmaceutical University
Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.
Eur J Med Chem 85: 468-79 (2014)
Taipei Medical University
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Eur J Med Chem 85: 418-37 (2014)
University Of Paris
Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents.
Eur J Med Chem 85: 399-407 (2014)
Yonsei University
Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: inhibitors of tubulin and angiogenesis.
Eur J Med Chem 85: 391-8 (2014)
University Of Oslo
Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.
Eur J Med Chem 85: 359-70 (2014)
Shandong University
Discovery and molecular modeling of novel 1-indolyl acetate--5-nitroimidazole targeting tubulin polymerization as antiproliferative agents.
Eur J Med Chem 85: 341-51 (2014)
Nanjing University
Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2a inhibitors.
J Med Chem 57: 7244-62 (2014)
Asubio Pharma
Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines.
J Med Chem 57: 7325-41 (2014)
University Of Kansas
Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.
J Med Chem 57: 7900-15 (2014)
Massachusetts Institute Of Technology
Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis.
J Med Chem 57: 7550-64 (2014)
Bristol-Myers Squibb
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
J Med Chem 57: 7412-24 (2014)
Abbvie
Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.
J Med Chem 57: 7136-40 (2014)
The University Of Tennessee Health Science Center
Lithocarpic Acids A-N, 3,4-seco-Cycloartane Derivatives from the Cupules of Lithocarpus polystachyus.
J Nat Prod 77: 1910-20 (2014)
Chinese Academy Of Sciences
Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.
Bioorg Med Chem Lett 24: 4209-14 (2014)
Julius-Maximilians-Universit£T W£Rzburg
Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase.
Bioorg Med Chem Lett 24: 4312-7 (2014)
Freie Universitaet Berlin
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
J Med Chem 57: 6403-18 (2014)
Universit£
Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-ß-d-glucopyranosylamines.
Bioorg Med Chem 22: 4810-25 (2014)
University Of Thessaly
Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.
Bioorg Med Chem Lett 24: 4187-91 (2014)
Pfizer
The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases.
Biochemistry 53: 5272-9 (2014)
University Of California Irvine
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach.
Eur J Med Chem 85: 293-303 (2014)
Shandong University
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.
Eur J Med Chem 85: 268-88 (2014)
National Taiwan University
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
J Med Chem 57: 7073-84 (2014)
P. J. Safarik University
The biology and synthesis of ?-hydroxytropolones.
Medchemcomm 5: 842-852 (2014)
City University Of New York
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aß aggregation, andß-secretase.
Bioorg Med Chem 22: 4784-91 (2014)
Central China Normal University
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.
Bioorg Med Chem Lett 24: 4332-5 (2014)
Arena Pharmaceuticals
Prediction of Thorough QT study results using action potential simulations based on ion channel screens.
J Pharmacol Toxicol Methods 70: 246-54 (2014)
University Of Oxford
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.
Bioorg Med Chem 22: 4694-703 (2014)
National Health Research Institutes
Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition.
Bioorg Med Chem 22: 4704-10 (2014)
Clermont Universit£
Development of dual targeting inhibitors against aggregations of amyloid-ß and tau protein.
Eur J Med Chem 85: 228-34 (2014)
Tokyo Institute Of Technology
Structure-based optimization of non-peptidic Cathepsin D inhibitors.
Bioorg Med Chem Lett 24: 4141-50 (2014)
Merck
Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
Bioorg Med Chem Lett 24: 3739-43 (2014)
Beijing Institute Of Pharmacology And Toxicology
A human fatty acid synthase inhibitor binds ß-ketoacyl reductase in the keto-substrate site.
Nat Chem Biol 10: 774-9 (2014)
Glaxosmithkline
Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents.
Eur J Med Chem 85: 215-27 (2014)
Shenyang Pharmaceutical University
Development of quinone analogues as dynamin GTPase inhibitors.
Eur J Med Chem 85: 191-206 (2014)
The University Of Newcastle
Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles.
Medchemcomm 5: 816-825 (2014)
Clemson University
Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2.
Bioorg Med Chem 22: 4735-44 (2014)
China Pharmaceutical University
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4).
Bioorg Med Chem 22: 4759-69 (2014)
Uit The Arctic University Of Norway
Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.
Bioorg Med Chem 22: 4717-25 (2014)
Zhejiang University
Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists.
Bioorg Med Chem Lett 24: 4271-5 (2014)
Chung-Ang University
Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists.
Bioorg Med Chem Lett 24: 4281-5 (2014)
Korea Research Institute Of Chemical Technology
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J Med Chem 57: 7016-30 (2014)
University Of California Davis
Towards the development of chromone-based MEK1/2 modulators.
Eur J Med Chem 85: 127-38 (2014)
University Of Gothenburg
Discovery of highly potent TNFa inhibitors using virtual screen.
Eur J Med Chem 85: 119-26 (2014)
Peking University
Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.
Eur J Med Chem 85: 16-26 (2014)
Shanghai Institute Of Materia Medica (Simm)
Pyrrolo[3,2-b]quinoxaline derivatives as types I1/2 and II Eph tyrosine kinase inhibitors: structure-based design, synthesis, and in vivo validation.
J Med Chem 57: 6834-44 (2014)
University Of Z£Rich
Prostaglandin Derivatives: Nonaromatic Phosphodiesterase-4 Inhibitors from the Soft Coral Sarcophyton ehrenbergi.
J Nat Prod 77: 1928-36 (2014)
Sun Yat-Sen University
Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A.
J Nat Prod 77: 1817-24 (2014)
The University Of Kansas
N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
J Med Chem 57: 7293-316 (2014)
Sanofi R & D
The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.
J Med Chem 57: 6879-84 (2014)
Universidad Complutense De Madrid
One-pot heterogeneous synthesis of¿(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors.
Eur J Med Chem 85: 77-86 (2014)
University Of Perugia
Trends in research of antitrypanosomal agents among synthetic heterocycles.
Eur J Med Chem 85: 51-64 (2014)
Danylo Halytsky Lviv National Medical University
Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design.
Eur J Med Chem 85: 1-15 (2014)
Peking Union Medical College And Chinese Academy Of Medical Sciences
Further evaluation of the tropane analogs of haloperidol.
Bioorg Med Chem Lett 24: 4294-7 (2014)
Florida A&M University
Evaluation of class I HDAC isoform selectivity of largazole analogues.
Bioorg Med Chem Lett 24: 3728-31 (2014)
Duke University
Nostosins, Trypsin Inhibitors Isolated from the Terrestrial Cyanobacterium Nostoc sp. Strain FSN.
J Nat Prod 77: 1784-90 (2014)
University Of Helsinki
A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent.
J Med Chem 57: 7006-15 (2014)
Monash University
Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors.
J Med Chem 57: 7317-24 (2014)
The Scripps Research Institute
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
J Med Chem 57: 7031-41 (2014)
University Of North Carolina At Chapel Hill
Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.
J Med Chem 57: 6419-27 (2014)
La Trobe University
Design, Synthesis, and Evaluation of 4- and 5-Substituted
Medchemcomm 5: 826-830 (2014)
The Johns Hopkins University
In silico and pharmacological screenings identify novel serine racemase inhibitors.
Bioorg Med Chem Lett 24: 3732-5 (2014)
University Of Toyama
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.
Bioorg Med Chem 22: 4770-83 (2014)
Universit£
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-actingß2-adrenoceptor agonist.
Bioorg Med Chem Lett 24: 4341-7 (2014)
Novartis Institutes For Biomedical Research
Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1.
Eur J Med Chem 84: 739-45 (2014)
Chinese Academy Of Sciences
Discovery of N-(2-phenyl-1H-benzo[d]imidazol-5-yl)quinolin-4-amine derivatives as novel VEGFR-2 kinase inhibitors.
Eur J Med Chem 84: 698-707 (2014)
China Pharmaceutical University
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.
Eur J Med Chem 84: 614-27 (2014)
Universit£
Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted¿-opioid receptor agonists.
J Med Chem 57: 6845-60 (2014)
Westf£Lische Wilhelms-Universit£T M£Nster
Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells.
J Med Chem 57: 6973-88 (2014)
Indian Institute Of Science
An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases.
J Med Chem 57: 6468-78 (2014)
University Of Michigan
Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.
J Med Chem 57: 6458-67 (2014)
University Of British Columbia
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).
J Med Chem 57: 6632-41 (2014)
Amgen
Synthesis, screening and docking of small heterocycles as glycogen phosphorylase inhibitors.
Eur J Med Chem 84: 584-94 (2014)
Griffith University
Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking.
J Med Chem 57: 6729-38 (2014)
University Of California
Recent progress in sodium channel modulators for pain.
Bioorg Med Chem Lett 24: 3690-9 (2014)
Pfizer
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.
J Nat Prod 77: 1693-9 (2014)
University Of California
Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.
Bioorg Med Chem 22: 5020-34 (2014)
Universit£T Regensburg
Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-?.
J Med Chem 57: 6513-30 (2014)
Saarland University
Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site.
ACS Med Chem Lett 5: 736-741 (2014)
Xiamen University
Allosteric modulation of the G protein-coupled US28 receptor of human cytomegalovirus: are the small-weight inverse agonist of US28 'camouflaged' agonists?
Bioorg Med Chem Lett 24: 3744-7 (2014)
Friedrich Alexander University
The use of spirocyclic scaffolds in drug discovery.
Bioorg Med Chem Lett 24: 3673-82 (2014)
Vitae Pharmaceuticals
Bahamaolide A from the marine-derived Streptomyces sp. CNQ343 inhibits isocitrate lyase in Candida albicans.
Bioorg Med Chem Lett 24: 4291-3 (2014)
Seoul National University
Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives.
J Nat Prod 77: 1831-8 (2014)
University Of Shizuoka
Synthesis of tripeptides containing D-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception.
J Med Chem 57: 6861-6 (2014)
University Of Bologna
Dualsteric muscarinic antagonists--orthosteric binding pose controls allosteric subtype selectivity.
J Med Chem 57: 6739-50 (2014)
University Of W£Rzburg
Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.
Eur J Med Chem 84: 476-90 (2014)
University Of Padova
Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3K¿) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
Eur J Med Chem 84: 454-65 (2014)
The University Of Jordan
Azapropellanes with anti-influenza a virus activity.
ACS Med Chem Lett 5: 831-6 (2014)
Universitat De Barcelona
Sulfonamides with Potent Inhibitory Action and Selectivity against thea-Carbonic Anhydrase from Vibrio cholerae.
ACS Med Chem Lett 5: 826-30 (2014)
Universit£
Benzimidazoles: novel mycobacterial gyrase inhibitors from scaffold morphing.
ACS Med Chem Lett 5: 820-5 (2014)
Astrazeneca
Two Potent OXE-R Antagonists: Assignment of Stereochemistry.
ACS Med Chem Lett 5: 815-9 (2014)
Florida Institute Of Technology
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett 5: 803-8 (2014)
Bristol-Myers Squibb
Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.
ACS Med Chem Lett 5: 793-6 (2014)
Bharati Vidyapeeth'S College Of Pharmacy
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
ACS Med Chem Lett 5: 787-92 (2014)
Novartis Institutes For Biomedical Research
Synthesis and Pharmacological Evaluation of DH?E Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists.
ACS Med Chem Lett 5: 766-70 (2014)
University Of Copenhagen
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
ACS Med Chem Lett 5: 760-5 (2014)
Amri
Investigation of Cardiovascular Effects of Tetrahydro-ß-carboline sstr3 antagonists.
ACS Med Chem Lett 5: 748-53 (2014)
Merck Research Laboratories
Discovery of a Negative Allosteric Modulator of GABAB Receptors.
ACS Med Chem Lett 5: 742-7 (2014)
Chinese Academy Of Sciences
Pim kinase inhibitors for the treatment of cancer and possibly more.
ACS Med Chem Lett 5: 730-1 (2014)
Therachem Research Medilab (India)
Synthesis and evaluation of antidepressant-like activity of some 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.
Chem Biol Drug Des 85: 326-35 (2015)
Jagiellonian University Medical College
Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
Bioorg Med Chem 22: 4910-6 (2014)
The University Of Texas At Austin
Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.
Bioorg Med Chem 22: 4803-9 (2014)
Medical University Of Lodz
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.
Bioorg Med Chem 22: 4867-81 (2014)
Universit£T Regensburg
Design of granulatimide and isogranulatimide analogues as potential Chk1 inhibitors: Study of amino-platforms for their synthesis.
Bioorg Med Chem 22: 4961-7 (2014)
Universit£
Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors.
Bioorg Med Chem Lett 24: 3753-6 (2014)
Friedrich-Alexander University
Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease.
Chembiochem 15: 1591-8 (2014)
Northeast Ohio Medial University
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Bioorg Med Chem 22: 4968-97 (2014)
University Health Network
Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors.
Bioorg Med Chem 22: 4855-66 (2014)
Ewha Womans University
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.
Bioorg Med Chem 22: 4882-92 (2014)
Zhejiang University
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Bioorg Med Chem Lett 24: 3782-5 (2014)
Amgen
Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors.
Bioorg Med Chem Lett 24: 3802-6 (2014)
Kumamoto Health Science University
Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.
Bioorg Med Chem Lett 24: 3797-801 (2014)
H�Pital Kirchberg
Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kß inhibitors, useful as antiplatelet agents.
Bioorg Med Chem Lett 24: 3936-43 (2014)
Astrazeneca
Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors.
Eur J Med Chem 84: 444-53 (2014)
University Of Florence
Deoxyribonuclease inhibitors.
Eur J Med Chem 88: 101-11 (2014)
University Of Nis
Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists.
Eur J Med Chem 84: 404-16 (2014)
University Of Copenhagen
Discovery libraries targeting the major enzyme classes: the serine hydrolases.
Bioorg Med Chem Lett 24: 3807-13 (2014)
The Scripps Research Institute
Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.
Bioorg Med Chem Lett 24: 3886-90 (2014)
Lexicon Pharmaceuticals
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett 24: 3764-71 (2014)
Genentech
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition.
Bioorg Med Chem Lett 24: 3757-63 (2014)
Goethe-University Frankfurt
Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors.
Eur J Med Chem 84: 382-94 (2014)
Aurigene Discovery Technologies
Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.
Eur J Med Chem 84: 375-81 (2014)
Yazd University
Synthesis of novel chiral TBBt derivatives with hydroxyl moiety. Studies on inhibition of human protein kinase CK2a and cytotoxicity properties.
Eur J Med Chem 84: 364-74 (2014)
Warsaw University Of Technology
Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor.
Eur J Med Chem 84: 312-34 (2014)
National Taiwan University
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.
Eur J Med Chem 84: 302-11 (2014)
Goethe-University Frankfurt
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Eur J Med Chem 84: 284-301 (2014)
Swiss Institute Of Bioinformatics
Small molecule ghrelin receptor inverse agonists and antagonists.
J Med Chem 57: 8671-91 (2014)
Pfizer
Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli.
ACS Chem Biol 9: 2274-82 (2014)
Astrazeneca India
Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-D-Leu-Phe-D-Leu-Phe-OH.
Bioorg Med Chem 22: 3824-8 (2014)
Saga University
Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
J Med Chem 57: 6495-512 (2014)
Janssen-Cilag
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
J Med Chem 57: 6822-33 (2014)
University Of North Carolina At Chapel Hill
Synthesis of lantadene analogs with marked in vitro inhibition of lung adenocarcinoma and TNF-a induced nuclear factor-kappa B (NF-¿B) activation.
Bioorg Med Chem Lett 24: 3814-8 (2014)
Jaypee University Of Information Technology
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.
Bioorg Med Chem 22: 3982-8 (2014)
Sapienza University Of Rome
Development of radamide analogs as Grp94 inhibitors.
Bioorg Med Chem 22: 4083-98 (2014)
The University Of Kansas
Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.
J Med Chem 57: 6623-31 (2014)
Purdue Pharma
Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.
J Med Chem 57: 6795-808 (2014)
Universit£
Discovery of 1H-indole-2-carboxamides as novel inhibitors of the androgen receptor binding function 3 (BF3).
J Med Chem 57: 6867-72 (2014)
University Of British Columbia
First photoswitchable neurotransmitter transporter inhibitor: light-induced control of¿-aminobutyric acid transporter 1 (GAT1) activity in mouse brain.
J Med Chem 57: 6809-21 (2014)
Ludwig-Maximilians-Universit£T M£Nchen
Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.
Bioorg Med Chem 22: 3862-70 (2014)
University Of Rajshahi
Furazan and furoxan sulfonamides are stronga-carbonic anhydrase inhibitors and potential antiglaucoma agents.
Bioorg Med Chem 22: 3913-21 (2014)
Universit£
Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.
Bioorg Med Chem Lett 24: 3869-76 (2014)
Shanghai Institute Of Technology
Molecular determinants for improved activity at PPARa: structure-activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARa.
Bioorg Med Chem Lett 24: 4048-52 (2014)
Goethe-University Frankfurt
Discovery of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs.
Bioorg Med Chem Lett 24: 4336-40 (2014)
Mitsubishi Tanabe Pharma
Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells.
Bioorg Med Chem Lett 24: 3748-52 (2014)
Universit£
Quinolone-based HDAC inhibitors.
J Enzyme Inhib Med Chem 29: 555-62 (2014)
Orchid Chemicals & Pharmaceuticals
Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.
Eur J Med Chem 84: 240-6 (2014)
Sapienza University Of Rome
Flavones: an important scaffold for medicinal chemistry.
Eur J Med Chem 84: 206-39 (2014)
Punjabi University
Investigations of amide bond variation and biaryl modification in analogues ofa7 nAChR agonist SEN12333.
Eur J Med Chem 84: 200-5 (2014)
The University Of Sydney
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
J Med Chem 57: 6668-78 (2014)
Vertex Pharmaceuticals
Synthesis and cholinesterase inhibition of cativic acid derivatives.
Bioorg Med Chem 22: 3838-49 (2014)
Universidad Nacional Del Sur
Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPAR¿ agonists.
Bioorg Med Chem Lett 24: 4001-5 (2014)
Okayama University
Confronting the challenges of discovery of novel antibacterial agents.
Bioorg Med Chem Lett 24: 3683-9 (2014)
Sbs Pharma Consulting
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.
Bioorg Med Chem Lett 24: 3968-73 (2014)
University Of Kansas Specialized Chemistry Center
Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.
Bioorg Med Chem Lett 24: 3891-7 (2014)
Genentech
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: hit-to-lead optimization.
Bioorg Med Chem Lett 24: 3845-9 (2014)
Gedeon Richter
Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors.
Bioorg Med Chem Lett 24: 3898-902 (2014)
Takeda Pharmaceutical
Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors.
Eur J Med Chem 84: 181-93 (2014)
Universit£
Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.
Eur J Med Chem 84: 160-72 (2014)
Griffith University
New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.
Eur J Med Chem 84: 135-45 (2014)
Universit£
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targetingß-amyloid, tau, and cholinesterase pathologies.
Eur J Med Chem 84: 107-17 (2014)
Universitat De Barcelona
CoMFA and CoMSIA analysis of ACE-inhibitory, antimicrobial and bitter-tasting peptides.
Eur J Med Chem 84: 100-6 (2014)
Tianjin University
Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors.
Bioorg Med Chem 22: 3879-86 (2014)
La Trobe University
2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.
Bioorg Med Chem Lett 24: 4044-7 (2014)
Seoul National University
In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus.
Bioorg Med Chem Lett 24: 3923-7 (2014)
Pukyong National University
Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis¿-carbonic anhydrase.
Bioorg Med Chem Lett 24: 4006-10 (2014)
Universit£
Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors.
Bioorg Med Chem Lett 24: 3986-96 (2014)
Jamia Hamdard (Hamdard University)
Design and synthesis of pyrimidine molecules endowed with thiazolidin-4-one as new anticancer agents.
Eur J Med Chem 83: 630-45 (2014)
Jamia Hamdard (Hamdard University)
Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.
Bioorg Med Chem 22: 4028-41 (2014)
University Of Debrecen
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors.
Bioorg Med Chem 22: 4998-5012 (2014)
Nerviano Medical Sciences
Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorß (PDGF-Rß) guided by water thermodynamics.
J Med Chem 58: 170-82 (2015)
Christian-Albrechts-University Of Kiel
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
J Med Chem 57: 6642-52 (2014)
Astrazeneca
Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis
Biochemistry 53: 4671-4684 (2014)
University Of Pennsylvania
Structural basis for HTLV-1 protease inhibition by the HIV-1 protease inhibitor indinavir.
J Med Chem 57: 6266-72 (2014)
Philipps-Universit£T Marburg
Structure-based design ofß1i orß5i specific inhibitors of human immunoproteasomes.
J Med Chem 57: 6197-209 (2014)
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Development and biological evaluation of potent and selective c-KIT(D816V) inhibitors.
J Med Chem 57: 6428-43 (2014)
Korea Advanced Institute Of Science And Technology (Kaist)
Therapeutic potential of targeting the oncogenic SHP2 phosphatase.
J Med Chem 57: 6594-609 (2014)
Indiana University School Of Medicine
2,2'-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1.
Bioorg Med Chem 22: 3957-70 (2014)
Agricultural University Of Athens
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.
Bioorg Med Chem Lett 24: 3961-3 (2014)
Kyowa Hakko Kirin
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
J Med Chem 57: 5949-64 (2014)
Amgen
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