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Report error Found 88 Enz. Inhib. hit(s) with all data for entry = 50045813
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataIC50:  58nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083056(CHEMBL3422837)
Affinity DataIC50:  73nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083055(CHEMBL3422836)
Affinity DataIC50:  140nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083054(CHEMBL3422835)
Affinity DataIC50:  170nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083062(CHEMBL3422842)
Affinity DataIC50:  170nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082781(CHEMBL3422796)
Affinity DataIC50:  240nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083005(CHEMBL3422799)
Affinity DataIC50:  260nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083060(CHEMBL3422840)
Affinity DataIC50:  400nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083058(CHEMBL3422838)
Affinity DataIC50:  430nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083017(CHEMBL3422811)
Affinity DataIC50:  470nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083063(CHEMBL3422843)
Affinity DataIC50:  600nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083012(CHEMBL3422806)
Affinity DataIC50:  950nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083013(CHEMBL3422807)
Affinity DataIC50:  1.03E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083053(CHEMBL3422834)
Affinity DataIC50:  1.05E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083036(CHEMBL3422830)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083056(CHEMBL3422837)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082783(CHEMBL3422798)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083016(CHEMBL3422810)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082778(CHEMBL3422794)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083052(CHEMBL3422833)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083051(CHEMBL2251560)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083035(CHEMBL3422829)
Affinity DataIC50:  1.80E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083033(CHEMBL3422827)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083059(CHEMBL3422839)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083036(CHEMBL3422830)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083055(CHEMBL3422836)
Affinity DataIC50:  2.50E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083032(CHEMBL3422826)
Affinity DataIC50:  3.10E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083014(CHEMBL3422808)
Affinity DataIC50:  3.20E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083026(CHEMBL3422820)
Affinity DataIC50:  3.50E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083062(CHEMBL3422842)
Affinity DataIC50:  4.10E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083058(CHEMBL3422838)
Affinity DataIC50:  4.30E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083015(CHEMBL3422809)
Affinity DataIC50:  4.40E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083029(CHEMBL3422823)
Affinity DataIC50:  5.70E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083020(CHEMBL3422814)
Affinity DataIC50:  5.70E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083061(CHEMBL3422841)
Affinity DataIC50:  6.10E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083038(CHEMBL3422832)
Affinity DataIC50:  6.10E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083038(CHEMBL3422832)
Affinity DataIC50:  6.50E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083030(CHEMBL3422824)
Affinity DataIC50:  6.60E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083054(CHEMBL3422835)
Affinity DataIC50:  7.10E+3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082780(CHEMBL1451030)
Affinity DataIC50:  8.30E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083008(CHEMBL3422802)
Affinity DataIC50:  8.30E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083011(CHEMBL3422805)
Affinity DataIC50:  8.70E+3nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083061(CHEMBL3422841)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083063(CHEMBL3422843)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083064(CHEMBL3422844)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083034(CHEMBL3422828)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083037(CHEMBL3422831)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083064(CHEMBL3422844)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced intracellular Ca2+ level pre-treated 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083033(CHEMBL3422827)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTransient receptor potential cation channel subfamily V member 1(Human)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083034(CHEMBL3422828)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level pre-treated 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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