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Found 8 Enz. Inhib. hit(s) with all data for entry = 50044853
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032893(CHEMBL3342782)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using a-ketoglutarate as substrate by fluorescence biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032894(CHEMBL3342781)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as inhibition of [3C]2-hydroxyglutarate formation after 45 mins by LC-MS biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032892(CHEMBL3342783)
Affinity DataIC50:  11nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as inhibition of [3C]2-hydroxyglutarate formation after 45 mins by LC-MS biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032892(CHEMBL3342783)
Affinity DataIC50: <16nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using a-ketoglutarate as substrate by fluorescence biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032894(CHEMBL3342781)
Affinity DataIC50:  17nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using a-ketoglutarate as substrate by fluorescence biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032893(CHEMBL3342782)
Affinity DataIC50:  20nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as inhibition of [3C]2-hydroxyglutarate formation after 45 mins by LC-MS biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032891(CHEMBL3342784)
Affinity DataIC50:  194nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using a-ketoglutarate as substrate by fluorescence biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50032891(CHEMBL3342784)
Affinity DataIC50:  376nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) assessed as inhibition of [3C]2-hydroxyglutarate formation after 45 mins by LC-MS biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed