Compile Data Set for Download or QSAR
maximum 50k data
Found 52 Enz. Inhib. hit(s) with all data for entry = 50044926
LigandPNGBDBM50036330(CHEMBL3353090)
Affinity DataIC50:  5nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036340(CHEMBL3353100)
Affinity DataIC50:  8nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036336(CHEMBL3352824)
Affinity DataIC50:  11nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036326(CHEMBL3353086)
Affinity DataIC50:  15nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036315(CHEMBL3353099)
Affinity DataIC50:  19nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036337(CHEMBL3353096)
Affinity DataIC50:  22nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036331(CHEMBL3353091)
Affinity DataIC50:  25nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036507(CHEMBL3353560)
Affinity DataIC50:  26nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036332(CHEMBL3353092)
Affinity DataIC50:  27nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036500(CHEMBL3353556)
Affinity DataIC50:  36nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036509(CHEMBL3353562)
Affinity DataIC50:  41nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036502(CHEMBL3353557)
Affinity DataIC50:  45nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036508(CHEMBL3353561)
Affinity DataIC50:  52nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036505(CHEMBL3353559)
Affinity DataIC50:  58nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036334(CHEMBL3353094)
Affinity DataIC50:  60nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036333(CHEMBL3353093)
Affinity DataIC50:  68nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036511(CHEMBL3353563)
Affinity DataIC50:  76nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036321(CHEMBL3353081)
Affinity DataIC50:  85nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036400(CHEMBL3353554)
Affinity DataIC50:  120nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036339(CHEMBL3353098)
Affinity DataIC50:  135nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036343(CHEMBL3353553)
Affinity DataIC50:  140nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036342(CHEMBL3353552)
Affinity DataIC50:  160nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036335(CHEMBL3353095)
Affinity DataIC50:  178nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036322(CHEMBL3353082)
Affinity DataIC50:  190nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036327(CHEMBL3353087)
Affinity DataIC50:  200nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036341(CHEMBL3353101)
Affinity DataIC50:  260nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036328(CHEMBL3353088)
Affinity DataIC50:  260nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036324(CHEMBL3353084)
Affinity DataIC50:  270nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036329(CHEMBL3353089)
Affinity DataIC50:  280nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036323(CHEMBL3353083)
Affinity DataIC50:  320nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036512(CHEMBL3353564)
Affinity DataIC50:  340nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036494(CHEMBL3353555)
Affinity DataIC50:  500nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036338(CHEMBL3353097)
Affinity DataIC50:  603nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036316(CHEMBL2415089)
Affinity DataIC50:  620nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036325(CHEMBL3353085)
Affinity DataIC50:  650nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036513(CHEMBL3353565)
Affinity DataIC50:  670nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036318(CHEMBL3353078)
Affinity DataIC50:  710nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036503(CHEMBL3353558)
Affinity DataIC50:  790nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036317(CHEMBL2415092)
Affinity DataIC50:  850nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036320(CHEMBL3353080)
Affinity DataIC50:  6.17E+3nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036319(CHEMBL3353079)
Affinity DataIC50:  6.92E+3nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50:  8.50E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50036315(CHEMBL3353099)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50036315(CHEMBL3353099)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50036315(CHEMBL3353099)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50397830(CHEMBL2151164)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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