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Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
J Med Chem 55: 9312-30 (2012)
Cnrs
Conformational restriction approach toß-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
J Med Chem 55: 8838-58 (2012)
Shionogi
Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase.
Drug Metab Dispos 41: 24-9 (2012)
Washington State University
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine.
Eur J Med Chem 56: 246-253 (2012)
TBA
Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.
Bioorg Med Chem Lett 22: 6338-42 (2012)
Daiichi Sankyo
Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.
Bioorg Med Chem Lett 22: 6503-8 (2012)
Bristol-Myers Squibb
Trypsin resistance of a decapeptide KISS1R agonist containing an N¿-methylarginine substitution.
Bioorg Med Chem Lett 22: 6328-32 (2012)
Takeda Pharmaceutical
Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica.
Bioorg Med Chem Lett 22: 6410-2 (2012)
Hokkaido University
Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus.
J Med Chem 55: 10292-6 (2012)
University Of Bologna
Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger.
Biochemistry 51: 8293-306 (2012)
University Of Wisconsin
Synthesis and paroxonase activities of novel bromophenols.
J Enzyme Inhib Med Chem 28: 1073-9 (2013)
Atatürk University
Synthesis and characterization of phenolic Mannich bases and effects of these compounds on human carbonic anhydrase isozymes I and II.
J Enzyme Inhib Med Chem 28: 337-42 (2013)
Dumlupinar University
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.
J Med Chem 55: 8958-62 (2012)
Eberhard-Karls University
Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.
J Med Chem 55: 8685-99 (2012)
Janssen-Cilag
Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.
J Med Chem 55: 9988-97 (2012)
University Health Network
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Bioorg Med Chem 20: 6040-7 (2012)
Rajiv Gandhi Centre For Biotechnology
Novel amide- and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases.
Bioorg Med Chem 20: 6162-70 (2012)
Humboldt Universit£T Zu Berlin
Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates.
Bioorg Med Chem 20: 6080-8 (2012)
Cardiff University
Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two newa-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.
Bioorg Med Chem 21: 1516-21 (2013)
University Of Tampere And Tampere University Hospital
Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening.
Bioorg Med Chem Lett 22: 6333-7 (2012)
Sejong University
Synthesis and biological evaluation of 1a,25-dihydroxyvitamin D3 analogues with a long side chain at C12 and short C17 side chains.
J Med Chem 55: 8642-56 (2012)
Universidad De Santiago De Compostela
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
J Med Chem 55: 9331-45 (2012)
Merck Research Laboratories
Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists.
Bioorg Med Chem 20: 6097-108 (2012)
Glaxosmithkline
Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors.
Bioorg Med Chem 20: 6073-9 (2012)
University Of Colorado At Boulder
Potent small molecule Hedgehog agonists induce VEGF expression in vitro.
Bioorg Med Chem 20: 6465-81 (2012)
Universit£T Leipzig
Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: synthesis and SAR study as tyrosine kinase c-Met inhibitors.
Bioorg Med Chem Lett 22: 6368-72 (2012)
China Pharmaceutical University
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
J Med Chem 55: 9416-33 (2012)
Genentech
Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.
J Med Chem 55: 8549-58 (2012)
Sun Yat-Sen University
Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.
J Med Chem 55: 8341-9 (2012)
State Key Laboratory Of Bioreactor Engineering
Selective fluorescent nonpeptidic antagonists for vasopressin V2 GPCR: application to ligand screening and oligomerization assays.
J Med Chem 55: 8588-602 (2012)
University Of Strasburg
Spirocyclic sulfamides asß-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
J Med Chem 55: 9224-39 (2012)
Pfizer
Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone.
J Med Chem 55: 8615-29 (2012)
Sanofi-Aventis Deutschland
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem 55: 8827-37 (2012)
Astrazeneca
Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes.
ACS Med Chem Lett 3: 759-763 (2012)
TBA
Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology.
Drug Metab Dispos 40: 2374-80 (2012)
Bristol-Myers Squibb
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.
Eur J Med Chem 56: 225-236 (2012)
TBA
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors.
Eur J Med Chem 56: 210-216 (2012)
TBA
Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kß inhibitors.
Bioorg Med Chem Lett 22: 6381-4 (2012)
Sanofi
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
Bioorg Med Chem Lett 22: 6481-5 (2012)
Vanderbilt University Medical Center
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Bioorg Med Chem Lett 22: 6498-502 (2012)
Sun Yat-Sen University
Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry.
Bioorg Med Chem Lett 22: 6401-4 (2012)
Universit£
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.
Bioorg Med Chem 20: 6171-80 (2012)
Takeda Pharmaceutical
Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity.
Bioorg Med Chem 20: 6144-53 (2012)
National Taiwan University Hospital
Molecular mechanisms of acquired proteasome inhibitor resistance.
J Med Chem 55: 10317-27 (2012)
University Of California San Diego
Multitarget-directed benzylideneindanone derivatives: anti-ß-amyloid (Aß) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.
J Med Chem 55: 8483-92 (2012)
Sun Yat-Sen University
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L.
Chem Biol Drug Des 80: 971-80 (2012)
Epizyme
Oncoepigenomics: making histone lysine methylation count.
Eur J Med Chem 56: 179-194 (2012)
TBA
Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides.
Bioorg Med Chem Lett 22: 6391-6 (2012)
Takeda Pharmaceutical
Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.
Bioorg Med Chem Lett 22: 6469-74 (2012)
Lundbeck Research Usa
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.
Bioorg Med Chem 21: 1522-5 (2013)
Agri Ibrahim Cecen University
Effect of daurisoline on HERG channel electrophysiological function and protein expression.
J Nat Prod 75: 1539-45 (2012)
Huazhong University Of Science And Technology
Identification of multiple 5-HT4 partial agonist clinical candidates for the treatment of Alzheimer's disease.
J Med Chem 55: 9240-54 (2012)
Pfizer
Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists.
J Med Chem 55: 8450-63 (2012)
Eisai
Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold.
Bioorg Med Chem 20: 5738-44 (2012)
Tianjin Medical University
Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.
Bioorg Med Chem 20: 5810-31 (2012)
Kitasato University
Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates.
Eur J Med Chem 56: 155-165 (2012)
TBA
Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae.
J Agric Food Chem 60: 9874-81 (2012)
Northeast Agricultural University
cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.
J Med Chem 55: 8477-82 (2012)
Universit£
Discovery of 1H-pyrrolo[2,3-c]pyridine-7-carboxamides as novel, allosteric mGluR5 antagonists.
Bioorg Med Chem Lett 22: 6454-9 (2012)
Novartis Institutes For Biomedical Research
Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.
J Med Chem 55: 8735-44 (2012)
Shionogi
Enhanced anti-influenza agents conjugated with anti-inflammatory activity.
J Med Chem 55: 8493-501 (2012)
National Taiwan University
Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1.
J Med Chem 55: 8745-56 (2012)
Vu University Amsterdam
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug Metab Dispos 40: 2332-41 (2012)
Astrazeneca
D-proline-based peptidomimetic inhibitors of anthrax lethal factor.
Eur J Med Chem 56: 96-107 (2012)
TBA
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg Med Chem 20: 5705-19 (2012)
Mitsubishi Tanabe Pharma
Identification of novel ?7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric ?7 receptor ligand binding domain.
Bioorg Med Chem 20: 5992-6002 (2012)
Bezmialem Vakif University
JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities.
Bioorg Med Chem Lett 22: 6173-80 (2012)
Jenrin Discovery
Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors.
Bioorg Med Chem Lett 22: 6301-5 (2012)
Zhejiang Betapharma
Isomannide derivatives as new class of inhibitors for human kallikrein 7.
Bioorg Med Chem Lett 22: 6072-5 (2012)
Universidade Federal Do Tri£Ngulo Mineiro
Camptothecins in tumor homing via an RGD sequence mimetic.
Bioorg Med Chem Lett 22: 6509-12 (2012)
Sigma-Tau Industrie Farmaceutiche Riunite
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).
Bioorg Med Chem Lett 22: 6053-8 (2012)
The University Of Sydney
Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.
Bioorg Med Chem Lett 22: 6048-52 (2012)
Theravance
The effect of Pro(2) modifications on the structural and pharmacological properties of endomorphin-2.
J Med Chem 55: 8418-28 (2012)
Biological Research Center Of The Hungarian Academy Of Sciences
Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors.
J Med Chem 55: 8164-77 (2012)
University Of Copenhagen
Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor.
J Med Chem 55: 8440-9 (2012)
Institute Of Genetics And Molecular And Cellular Biology (Igbmc)
2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.
J Med Chem 55: 8392-408 (2012)
Seoul National University
Synthesis and characterization of metal complexes of heterocyclic sulfonamide as carbonic anhydrase inhibitors.
J Enzyme Inhib Med Chem 28: 311-5 (2013)
Dumlupinar University
In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B.
J Enzyme Inhib Med Chem 28: 1067-72 (2013)
Chulalongkorn University
Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors.
J Enzyme Inhib Med Chem 28: 1080-7 (2013)
Ankara University
Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen-4-one scaffold.
Bioorg Med Chem 20: 5757-62 (2012)
Chungnam National University
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: rational design and kinase selectivity profile of cell potent type II inhibitors.
Bioorg Med Chem Lett 22: 6237-41 (2012)
Array Biopharma
Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment?
Bioorg Med Chem Lett 22: 6039-47 (2012)
Leo Pharma
Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization.
J Med Chem 55: 7998-8006 (2012)
National Institute Of Allergy And Infectious Diseases
Structure-based design of highly selectiveß-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
J Med Chem 55: 9195-207 (2012)
Purdue University
A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
Bioorg Med Chem 20: 5915-27 (2012)
Kyoto University
A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors.
J Med Chem 55: 8429-39 (2012)
University Of Tuebingen
Novel aromatase inhibitors by structure-guided design.
J Med Chem 55: 8464-76 (2012)
State University Of New York Upstate Medical University
Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.
J Med Chem 55: 7759-71 (2012)
Brandeis University
Thrombin inhibitors from the freshwater cyanobacterium Anabaena compacta.
J Nat Prod 75: 1546-52 (2012)
Hokkaido University
Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo.
Drug Metab Dispos 40: 2315-23 (2012)
Johns Hopkins School Of Medicine
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinasea.
J Med Chem 55: 8007-20 (2012)
Genentech
Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.
J Med Chem 55: 8318-29 (2012)
Universita` Degli Studi Di Sassari
Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.
Eur J Med Chem 56: 30-38 (2012)
TBA
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.
Bioorg Med Chem 20: 5884-92 (2012)
Sun Yat-Sen University
Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase.
Bioorg Med Chem 20: 5763-73 (2012)
Northwestern University
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.
Bioorg Med Chem Lett 22: 6286-91 (2012)
Glenmark Pharmaceuticals
Ago-allosteric modulators of human glucagon-like peptide 2 receptor.
Bioorg Med Chem Lett 22: 6126-35 (2012)
Eisai
Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048.
Drug Metab Dispos 40: 2297-306 (2012)
Chdi Management/Chdi Foundation
Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors.
Eur J Med Chem 56: 10-16 (2012)
TBA
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.
Bioorg Med Chem Lett 22: 6116-9 (2012)
Yeungnam University
Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-a receptors.
Bioorg Med Chem Lett 22: 6233-6 (2012)
Washington University
Phenethyl nicotinamides, a novel class of Na(V)1.7 channel blockers: structure and activity relationship.
Bioorg Med Chem Lett 22: 6108-15 (2012)
Astrazeneca
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists.
Bioorg Med Chem Lett 22: 6205-11 (2012)
Astrazeneca
Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Bioorg Med Chem Lett 22: 6181-4 (2012)
Bristol-Myers Squibb
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorg Med Chem 20: 5864-83 (2012)
Dainippon Sumitomo Pharma
Oxygenation of monoenoic fatty acids by CYP175A1, an orphan cytochrome P450 from Thermus thermophilus HB27.
Biochemistry 51: 7880-90 (2012)
Tata Institute Of Fundamental Research
Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells.
J Nat Prod 75: 1553-9 (2012)
University Of Mississippi
Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors.
J Med Chem 55: 8188-92 (2012)
Korea Institute Of Science And Technology
EC144 is a potent inhibitor of the heat shock protein 90.
J Med Chem 55: 7786-95 (2012)
Biogen Idec
Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.
J Med Chem 55: 8183-7 (2012)
Chinese Academy Of Sciences
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.
J Med Chem 55: 8110-27 (2012)
Array Biopharma
Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor¿.
J Med Chem 55: 8303-17 (2012)
Universit£
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.
Bioorg Med Chem Lett 22: 6242-7 (2012)
Yale University
Amide-based derivatives ofß-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects.
Bioorg Med Chem Lett 22: 6200-4 (2012)
University Of Sydney
An investigation into the structure-activity relationships associated with the systematic modification of theß(2)-adrenoceptor agonist indacaterol.
Bioorg Med Chem Lett 22: 6280-5 (2012)
Novartis Institutes For Biomedical Research
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.
Bioorg Med Chem Lett 22: 6224-8 (2012)
Beijing Institute Of Pharmacology & Toxicology
2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.
Bioorg Med Chem Lett 22: 6185-9 (2012)
University Of Puerto Rico
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
J Med Chem 55: 8193-7 (2012)
Sapienza University Of Rome
Chemokine receptor antagonists.
J Med Chem 55: 9363-92 (2012)
National Heart And Lung Institute
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors.
Drug Metab Dispos 40: 2239-49 (2012)
Amgen
A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
Bioorg Med Chem Lett 22: 6190-4 (2012)
The University Of Queensland
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg Med Chem Lett 22: 6212-7 (2012)
Amgen
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1.
Bioorg Med Chem Lett 22: 6160-5 (2012)
University Of Hyderabad Campus
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
J Nat Prod 75: 1632-6 (2012)
National Cancer Institute-Frederick
Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands toa4ß2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.
J Med Chem 55: 8028-37 (2012)
University Of Illinois At Chicago
Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease.
J Med Chem 55: 9156-69 (2012)
Amgen
Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation.
J Med Chem 55: 7978-87 (2012)
Georgia State University
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT7 receptor antagonists.
Eur J Med Chem 56: 348-360 (2012)
TBA
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.
Bioorg Med Chem Lett 22: 6218-23 (2012)
Amgen
Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.
Bioorg Med Chem Lett 22: 6256-60 (2012)
University Of Lisbon
Design and synthesis ofß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction ofß-amyloid peptides.
J Med Chem 55: 9346-61 (2012)
Astrazeneca
Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L.
J Med Chem 55: 8066-74 (2012)
Baylor College Of Medicine
Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines.
J Med Chem 55: 8137-51 (2012)
University Of Kansas
Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of
J Med Chem 55: 8091-109 (2012)
Pfizer
PI3Kd and PI3K¿ as targets for autoimmune and inflammatory diseases.
J Med Chem 55: 8559-81 (2012)
Amgen
Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
J Med Chem 55: 9393-413 (2012)
University Of Oxford
Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy.
J Med Chem 55: 8199-208 (2012)
Cylene Pharmaceuticals
Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation.
ACS Med Chem Lett 3: 544-549 (2012)
TBA
[¹8F]FE@SNAP-A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): microfluidic and vessel-based approaches.
Bioorg Med Chem 20: 5936-40 (2012)
Medical University Of Vienna
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
Bioorg Med Chem 20: 5550-8 (2012)
University Of Texas
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid ?-protein.
Bioorg Med Chem 20: 5844-9 (2012)
University Of Tsukuba
Armeniaspiroles, a new class of antibacterials: Antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A.
Bioorg Med Chem Lett 22: 6292-6 (2012)
Sanofi Research & Development
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.
J Med Chem 55: 8075-90 (2012)
National Institute Of Diabetes And Digestive And Kidney Diseases
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases.
Bioorg Med Chem Lett 22: 6229-32 (2012)
Baylor College Of Medicine
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor.
J Med Chem 55: 7437-49 (2012)
Universit£T Leipzig
Crystal structure of human aurora B in complex with INCENP and VX-680.
J Med Chem 55: 7841-8 (2012)
University Of Oxford
Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents.
Bioorg Med Chem Lett 22: 5857-62 (2012)
Zydus Research Centre
Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).
Bioorg Med Chem Lett 22: 5811-3 (2012)
University Of Copenhagen
Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.
J Med Chem 55: 8152-63 (2012)
Hokkaido University
7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.
J Med Chem 55: 7967-77 (2012)
University Of Bonn
Pd-catalyzed direct C-H bond functionalization of spirocyclics1 ligands: generation of a pharmacophore model and analysis of the reverse binding mode by docking into a 3D homology model of thes1 receptor.
J Med Chem 55: 8047-65 (2012)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils andß-amyloid plaques in Alzheimer's disease models.
J Med Chem 55: 9170-80 (2012)
Technische Universit£T Darmstadt
Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.
J Med Chem 55: 7480-501 (2012)
Myrexis
Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
J Med Chem 55: 8021-7 (2012)
Indiana University School Of Medicine
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
Bioorg Med Chem 20: 5496-506 (2012)
Takeda Pharmaceutical
Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.
Eur J Med Chem 56: 282-291 (2012)
TBA
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.
Eur J Med Chem 56: 292-300 (2012)
TBA
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
Bioorg Med Chem Lett 22: 5936-41 (2012)
Vanderbilt University Medical Center
Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi.
Bioorg Med Chem Lett 22: 5885-8 (2012)
Harvard Medical School
Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells.
J Med Chem 55: 7560-70 (2012)
Universitat Ramon Llull
Synthesis, crystal structure, in vitro acetohydroxyacid synthase inhibition, in vivo herbicidal activity, and 3D-QSAR of new asymmetric aryl disulfides.
J Agric Food Chem 60: 8286-93 (2012)
Nankai University
Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor.
J Med Chem 55: 7772-85 (2012)
Astellas Pharma
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Drug Metab Dispos 40: 2174-84 (2012)
University Of Arkansas For Medical Sciences
Ras inhibition via direct Ras binding--is there a path forward?
Bioorg Med Chem Lett 22: 5766-76 (2012)
Genentech
Exploration of the structure-activity relationship of the diaryl anilide class of ligands for translocator protein--potential novel positron emitting tomography imaging agents.
Bioorg Med Chem Lett 22: 5795-800 (2012)
Ge Healthcare
Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Bioorg Med Chem Lett 22: 5876-84 (2012)
Pfizer
Modulation of cofilin phosphorylation by inhibition of the Lim family kinases.
Bioorg Med Chem Lett 22: 5995-8 (2012)
Bristol-Myers Squibb Research And Development
Discovery and optimization of a series of liver X receptor antagonists.
Bioorg Med Chem Lett 22: 5966-70 (2012)
Amgen
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis.
Bioorg Med Chem Lett 22: 5893-7 (2012)
Fate Therapeutics
UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety.
Bioorg Med Chem 20: 5483-95 (2012)
Bar-Ilan University
Synthesis and pharmacological evaluation of indolinone derivatives as novel ghrelin receptor antagonists.
Bioorg Med Chem 20: 5623-36 (2012)
Sanofi Research
Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase and tyrosinase inhibitors.
Bioorg Med Chem 20: 5649-57 (2012)
Solapur University
Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase.
Bioorg Med Chem Lett 22: 5889-92 (2012)
University Of California
A novel aminopeptidase N inhibitor developed by virtual screening approach.
Bioorg Med Chem Lett 22: 5863-9 (2012)
Shandong Academy Of Sciences
Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2.
Bioorg Med Chem Lett 22: 5979-83 (2012)
Merck Research Laboratories
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.
Bioorg Med Chem Lett 22: 5909-14 (2012)
Merck Serono
Inhibition ofa-class cytosolic human carbonic anhydrases I, II, IX and XII, andß-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.
Bioorg Med Chem Lett 22: 5801-6 (2012)
Universit£
Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors.
Bioorg Med Chem Lett 22: 5870-5 (2012)
Nanjing University
Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents.
Eur J Med Chem 55: 395-408 (2012)
Virginia Commonwealth University
Probing the peripheral site of human butyrylcholinesterase.
Biochemistry 51: 7046-53 (2012)
Dalhousie University
Discovery of 1-(ß-amino substituted-ß-alanyl)-N,N-dimethylindoline-2-carboxamides as novel nonpeptide antagonists of nociceptin/orphanin FQ receptor: efficient design, synthesis, and structure-activity relationship studies.
Eur J Med Chem 55: 228-42 (2012)
Pfizer
Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors.
Bioorg Med Chem 20: 5473-82 (2012)
Chinese Academy Of Sciences
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Bioorg Med Chem 20: 5507-17 (2012)
Takeda Pharmaceutical
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.
Bioorg Med Chem Lett 22: 5948-51 (2012)
University Of Ljubljana
Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): a target for heart failure and platelet aggregation.
Bioorg Med Chem Lett 22: 6010-5 (2012)
Indian Institute Of Chemical Technology
Discovery of diarylhydantoins as new selective androgen receptor modulators.
J Med Chem 55: 8225-35 (2012)
Galapagos, Parc Biocitech
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem 55: 7796-816 (2012)
Amgen
Targeting the hinge glycine flip and the activation loop: novel approach to potent p38a inhibitors.
J Med Chem 55: 7862-74 (2012)
Eberhard Karls University T£Bingen
Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.
J Med Chem 55: 7920-39 (2012)
F. Hoffmann-La Roche
Carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase IX and matrix metalloproteinase-2. Toward nontoxic chemotherapy targeting tumor microenvironment.
J Med Chem 55: 7875-82 (2012)
The Hebrew University Of Jerusalem
Water mediated ligand functional group cooperativity: the contribution of a methyl group to binding affinity is enhanced by a COO(-) group through changes in the structure and thermodynamics of the hydration waters of ligand-thermolysin complexes.
J Med Chem 55: 8283-302 (2012)
The State University Of New York
A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.
Chembiochem 13: 2128-36 (2012)
Moffitt Cancer Center
Natural product coumarins that inhibit human carbonic anhydrases.
Bioorg Med Chem 21: 1539-43 (2013)
Griffith University
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett 22: 5903-8 (2012)
Merck Research Laboratories
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
J Med Chem 55: 7525-45 (2012)
Universidade Federal Do Rio De Janeiro
Design and characterization of a selenium-containing inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa), a zinc-containing metalloprotease.
J Med Chem 55: 7696-705 (2012)
Showa Pharmaceutical University
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
J Med Chem 55: 7061-79 (2012)
Glaxosmithkline
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.
Bioorg Med Chem Lett 22: 5919-23 (2012)
Astrazeneca
Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-¿B and Akt signalling.
Eur J Med Chem 55: 346-57 (2012)
Sun Yat-Sen University
The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.
Eur J Med Chem 55: 358-74 (2012)
University Of Patras
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.
J Med Chem 55: 7719-35 (2012)
Universit£
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
J Med Chem 55: 7828-40 (2012)
Chugai Pharmaceutical
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
J Med Chem 55: 7472-9 (2012)
Novartis Institutes For Biomedical Research
Antiplasmodial activities of 4-aminoquinoline-statine compounds.
Bioorg Med Chem Lett 22: 5915-8 (2012)
Universit£
Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones.
Bioorg Med Chem Lett 22: 5833-8 (2012)
Kyorin Pharmaceutical
Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett 22: 5942-7 (2012)
Amgen
Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands.
Bioorg Med Chem 20: 5568-82 (2012)
Dainippon Sumitomo Pharma
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
Bioorg Med Chem 20: 5928-35 (2012)
Korea Research Institute Of Bioscience And Biotechnology
Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site 'capping' phenyls.
Bioorg Med Chem 20: 5583-91 (2012)
Mcgill University
The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
Bioorg Med Chem 21: 1534-8 (2013)
Universit£
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.
Bioorg Med Chem 20: 5527-36 (2012)
Shandong University
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem 20: 5600-15 (2012)
Takeda Pharmaceutical
Synthesis, in vitro Biological Evaluation and Molecular Docking Studies of Benzimidamides as Potential BACE1 Inhibitors.
Chem Biol Drug Des 80: 775-80 (2012)
Peking University Health Science Center
A new class of selective and potent 7-dehydrocholesterol reductase inhibitors.
J Med Chem 55: 7614-22 (2012)
Martin-Luther-Universit£T Halle-Wittenberg
Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.
J Med Chem 55: 7900-8 (2012)
Aarhus University
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.
J Med Chem 55: 7417-24 (2012)
University Of Ljubljana
Synthesis and biological evaluation of tyrosine modified analogues of thea4ß7 integrin inhibitor biotin-R8ERY.
Bioorg Med Chem 20: 5139-49 (2012)
University Of Auckland
Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.
Bioorg Med Chem Lett 22: 5396-404 (2012)
Exelixis
Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.
Bioorg Med Chem Lett 22: 5360-2 (2012)
Menarini Ricerche Pomezia
Highly potent aminopyridines as Syk kinase inhibitors.
Bioorg Med Chem Lett 22: 5419-23 (2012)
RhôNe-Poulenc Rorer
Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty.
Bioorg Med Chem Lett 22: 5600-7 (2012)
Astrazeneca
Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1).
Bioorg Med Chem Lett 22: 5748-51 (2012)
Activx Biosciences
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1¿) inhibitors.
Bioorg Med Chem Lett 22: 5392-5 (2012)
Amgen
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.
J Med Chem 55: 7425-36 (2012)
University Of Washington
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase AKR1C3.
J Med Chem 55: 7746-58 (2012)
University Of Auckland
Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.
J Med Chem 55: 7686-95 (2012)
Genentech
Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.
J Med Chem 55: 7378-91 (2012)
Wayne State University
Discovery and in vivo evaluation of dual PI3Kß/d inhibitors.
J Med Chem 55: 7667-85 (2012)
Amgen
Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase.
J Nat Prod 75: 1451-8 (2012)
University Of British Columbia
Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.
J Med Chem 55: 7360-77 (2012)
The University Of Tokyo
Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist.
J Med Chem 55: 7623-35 (2012)
Bar-Ilan University
Design, synthesis, and structure-activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists.
Bioorg Med Chem Lett 22: 5372-8 (2012)
Eisai
Near-infrared fluorescent divalent RGD ligand for integrinavß3-targeted optical imaging.
Bioorg Med Chem Lett 22: 5405-9 (2012)
Washington University
High-affinity and selective dopamine D3 receptor full agonists.
Bioorg Med Chem Lett 22: 5612-7 (2012)
University Of Michigan
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors.
J Enzyme Inhib Med Chem 28: 1040-7 (2013)
Anadolu University
A fluorescent reporter of ATP binding-competent receptor kinases.
Bioorg Med Chem Lett 22: 5532-5 (2012)
University Of Miami
N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor.
Bioorg Med Chem Lett 22: 5485-92 (2012)
Astrazeneca
Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors.
Eur J Med Chem 61: 84-94 (2013)
Chinese Academy Of Sciences
Inhibition of human topoisomerases I and II by simocyclinone D8.
J Nat Prod 75: 1485-9 (2012)
University Of Minnesota Medical School
Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy.
J Med Chem 55: 7957-66 (2012)
Pfizer
Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B.
Dalton Trans 41: 11116-24 (2012)
Shanxi University
Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors.
Bioorg Med Chem 20: 5169-80 (2012)
Chinese Academy Of Sciences
C-N bond formation under Cu-catalysis: synthesis and in vitro evaluation of N-aryl substituted thieno[2,3-d]pyrimidin-4(3H)-ones against chorismate mutase.
Bioorg Med Chem 20: 5127-38 (2012)
University Of Hyderabad Campus
Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1.
Bioorg Med Chem 20: 5117-26 (2012)
Poznan University Of Medical Sciences
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potentß-secretase inhibitors.
Bioorg Med Chem Lett 22: 5460-5 (2012)
Purdue University
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor.
Bioorg Med Chem Lett 22: 5625-9 (2012)
Glaxosmithkline
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Bioorg Med Chem Lett 22: 5445-50 (2012)
Novartis Institutes For Biomedical Research
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
J Med Chem 55: 7849-61 (2012)
Actelion Pharmaceuticals
Novelß-amino acid derivatives as inhibitors of cathepsin A.
J Med Chem 55: 7636-49 (2012)
Sanofi-Aventis Deutschland
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.
J Med Chem 55: 7080-9 (2012)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett 22: 5563-8 (2012)
Astrazeneca
Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes.
Bioorg Med Chem Lett 22: 5721-6 (2012)
Pfizer
Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors.
Bioorg Med Chem Lett 22: 5428-37 (2012)
Chinese Academy Of Sciences
Discovery of potent and selective rhodanine type IKKß inhibitors by hit-to-lead strategy.
Bioorg Med Chem Lett 22: 5668-74 (2012)
Korea University
Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.
Bioorg Med Chem Lett 22: 5675-8 (2012)
Northeast Ohio Medical University
The development of first Staphylococcus aureus SplB protease inhibitors: phosphonic analogues of glutamine.
Bioorg Med Chem Lett 22: 5574-8 (2012)
Wroclaw University Of Technology
New cytosine derivatives as inhibitors of DNA methylation.
Eur J Med Chem 55: 243-54 (2012)
Polish Academy Of Sciences
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.
Bioorg Med Chem 20: 5181-7 (2012)
Industrial Research
Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles.
Bioorg Med Chem Lett 22: 5498-502 (2012)
Shionogi
Orally available pyridinylpyrimidine derivatives as novel RANKL-induced osteoclastogenesis inhibitors.
Bioorg Med Chem Lett 22: 5681-4 (2012)
Astellas Pharma
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.
Bioorg Med Chem Lett 22: 5536-40 (2012)
Tufts University School Of Medicine
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.
Bioorg Med Chem Lett 22: 5579-83 (2012)
University Of Siena
New positron emission tomography (PET) radioligand for imagings-1 receptors in living subjects.
J Med Chem 55: 8272-82 (2012)
Stanford University
Selected chromone derivatives as inhibitors of monoamine oxidase.
Bioorg Med Chem Lett 22: 5480-4 (2012)
North-West University
Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity.
Bioorg Med Chem Lett 22: 5493-7 (2012)
The University Of Sydney
Dipeptidyl peptidase-4 inhibitor withß-amino amide scaffold: synthesis, SAR and biological evaluation.
Bioorg Med Chem Lett 22: 5545-9 (2012)
Dong-A Pharm.
Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C virus (HCV).
J Med Chem 55: 7650-66 (2012)
Boehringer Ingelheim (Canada)
Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1.
J Med Chem 55: 6802-13 (2012)
Agricultural University Of Athens
Chemoenzymatic synthesis and evaluation of 3-azabicyclo[3.2.0]heptane derivatives as dopaminergic ligands.
Eur J Med Chem 55: 255-61 (2012)
University Of Tartu
Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.
J Nat Prod 75: 1436-40 (2012)
University Of Utah
Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists.
J Med Chem 55: 7141-53 (2012)
University Of North Carolina At Chapel Hill
Inhibitors for Bacterial Cell-Wall Recycling.
ACS Med Chem Lett 3: 238-242 (2012)
TBA
Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia.
Bioorg Med Chem Lett 22: 5595-9 (2012)
Omeros
Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis.
Bioorg Med Chem 20: 5247-53 (2012)
University Of California Davis
Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.
Chem Biol 19: 875-82 (2012)
Yale University School Of Medicine
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.
Eur J Med Chem 55: 94-107 (2012)
Neuraxon
Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction.
ACS Med Chem Lett 3: 501-504 (2012)
TBA
Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists.
Bioorg Med Chem 20: 5235-46 (2012)
Astellas Pharma
Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors.
Bioorg Med Chem Lett 22: 5523-6 (2012)
University Of Athens
Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.
Bioorg Med Chem Lett 22: 5352-9 (2012)
Astrazeneca
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
Eur J Med Chem 55: 58-66 (2012)
Universit£
Discovery of a novel noniminosugar acida glucosidase chaperone series.
J Med Chem 55: 7546-59 (2012)
National Center For Advancing Translational Sciences
Current landscape of phosphodiesterase 10A (PDE10A) inhibition.
J Med Chem 55: 7299-331 (2012)
Pfizer
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg Med Chem Lett 22: 5714-20 (2012)
Amgen
Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease.
Bioorg Med Chem Lett 22: 5700-3 (2012)
Kyoto University
Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers.
Bioorg Med Chem Lett 22: 5618-24 (2012)
Astrazeneca
N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.
Bioorg Med Chem Lett 22: 5658-62 (2012)
Lundbeck Research Usa
New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.
Bioorg Med Chem 20: 5296-304 (2012)
Universit£
Small molecules that protect against ?-amyloid-induced cytotoxicity by inhibiting aggregation of ?-amyloid.
Bioorg Med Chem 20: 4921-35 (2012)
Korea Institute Of Science And Technology
Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists.
Bioorg Med Chem 20: 5254-61 (2012)
National Institutes Of Health
Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities.
Bioorg Med Chem 20: 4901-14 (2012)
Meiji Pharmaceutical University
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT).
Bioorg Med Chem 20: 4936-41 (2012)
Kanazawa University
Stabilization and structural alteration of the G-quadruplex DNA made from the human telomeric repeat mediated by Tröger's base based novel benzimidazole derivatives.
J Med Chem 55: 7460-71 (2012)
India Institute Of Science
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
J Med Chem 55: 7193-207 (2012)
Glaxosmithkline
Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.
J Med Chem 55: 7010-20 (2012)
Leiden/Amsterdam Center For Drug Research
Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.
Bioorg Med Chem 20: 5033-41 (2012)
Mitsubishi Tanabe Pharma
Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors.
Bioorg Med Chem 20: 4889-94 (2012)
Liaoning Normal University
Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
J Med Chem 55: 7706-18 (2012)
Ume£
Synthesis and evaluation of novela-fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracers.
J Med Chem 55: 7154-62 (2012)
Institute Of Technology (Eth) Zurich
Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics.
Drug Metab Dispos 40: 2009-20 (2012)
Chinese Academy Of Sciences
Synthesis of benzo-annulated tryptanthrins and their biological properties.
Bioorg Med Chem 20: 4962-7 (2012)
Yeungnam University
SAR studies around a series of triazolopyridines as potent and selective PI3K¿ inhibitors.
Bioorg Med Chem Lett 22: 5257-63 (2012)
Cellzome
Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.
Bioorg Med Chem Lett 22: 5208-14 (2012)
Spanish National Cancer Research Centre (Cnio)
Discovery and characterization of novel allosteric FAK inhibitors.
Eur J Med Chem 61: 49-60 (2013)
Takeda Pharmaceutical
Synthesis, biological evaluation, and molecular docking studies of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)aniline derivatives as novel anticancer agents.
Bioorg Med Chem 20: 4895-900 (2012)
Changzhou University
(+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibitinga-glucosidase.
Bioorg Med Chem Lett 22: 5215-7 (2012)
Chulalongkorn University
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.
Eur J Med Chem 55: 23-31 (2012)
P. J. Safarik University
Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases.
Eur J Med Chem 55: 39-48 (2012)
China Pharmaceutical University
The optimization of pyridazinone series of glucan synthase inhibitors.
Bioorg Med Chem Lett 22: 5268-71 (2012)
Merck Research Laboratories
Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors.
Eur J Med Chem 55: 32-8 (2012)
National Health Research Institutes
Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors.
J Med Chem 55: 6716-23 (2012)
Institute For Medical Research And Occupational Health
Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.
Drug Metab Dispos 40: 2002-8 (2012)
University Of Connecticut
Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy.
Drug Metab Dispos 41: 270-4 (2013)
Amgen
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.
Bioorg Med Chem Lett 22: 5150-6 (2012)
Astrazeneca
Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.
J Med Chem 55: 7262-72 (2012)
University Of California
Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.
Eur J Med Chem 54: 626-36 (2012)
Universit£
Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.
J Med Chem 55: 7021-36 (2012)
Hoffmann-La Roche
A straightforward approach for engineering efficacy and selectivity at GPCRs.
J Med Chem 55: 6687-8 (2012)
Universit£
Synthesis, inhibitory activity and molecular docking studies of two Cu(II) complexes against Helicobacter pylori urease.
J Enzyme Inhib Med Chem 27: 528-32 (2012)
Wuhan Textile University
Conformation-specific effects of Raf kinase inhibitors.
J Med Chem 55: 7332-41 (2012)
Takeda California
Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
J Med Chem 55: 7114-40 (2012)
Boehringer Ingelheim Pharmaceuticals
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.
J Med Chem 55: 7392-416 (2012)
Moffitt Cancer Center
Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines.
J Enzyme Inhib Med Chem 28: 870-5 (2013)
Giresun University
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Bioorg Med Chem Lett 22: 5222-6 (2012)
Glaxosmithkline
Selective non-lipid modulator of LPA5 activity in human platelets.
Bioorg Med Chem Lett 22: 5239-43 (2012)
Sanofi-Aventis Deutschland
Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors.
Bioorg Med Chem Lett 22: 5169-73 (2012)
Gakushuin University
Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization.
J Med Chem 55: 6762-75 (2012)
Universit£
Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-ß3-pseudopeptide agonist.
J Med Chem 55: 7516-24 (2012)
Institute For Research And Innovation In Biomedicine (Irib)
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.
Bioorg Med Chem 20: 4942-53 (2012)
Universit£
The SAR analysis of TRPV1 agonists with thea-methylated B-region.
Bioorg Med Chem Lett 22: 5227-31 (2012)
Seoul National University
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorg Med Chem Lett 22: 5317-21 (2012)
University Of Siena
C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor.
Bioorg Med Chem Lett 22: 5322-5 (2012)
University Of Hawaii At Manoa
Identification of new¿-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.
Bioorg Med Chem 20: 5012-6 (2012)
University Of Salerno
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.
Eur J Med Chem 54: 764-70 (2012)
Chinese Academy Of Sciences
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Eur J Med Chem 54: 750-63 (2012)
Universit£
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Bioorg Med Chem Lett 22: 5264-7 (2012)
University Of Washington
Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.
Bioorg Med Chem Lett 22: 5244-8 (2012)
F. Hoffmann-La Roche
Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.
Bioorg Med Chem Lett 22: 5326-9 (2012)
Janssen Pharmaceutical Companies Of Johnson & Johnson
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
J Med Chem 55: 9181-94 (2012)
Targacept
Shape-based reprofiling of FDA-approved drugs for the H1 histamine receptor.
J Med Chem 55: 7054-60 (2012)
University Of Oxford
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor.
J Med Chem 55: 6975-9 (2012)
Vanderbilt University Medical Center
Evaluation of new scaffolds of myeloperoxidase inhibitors by rational design combined with high-throughput virtual screening.
J Med Chem 55: 7208-18 (2012)
Universit£
Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.
Bioorg Med Chem 21: 3982-95 (2013)
University Of Pittsburgh
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases.
Bioorg Med Chem 20: 5027-32 (2012)
Groningen Research Institute Of Pharmacy
Synthesis and in vitro evaluation ofa-synuclein ligands.
Bioorg Med Chem 20: 4625-34 (2012)
Washington University
Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1?-p300 interaction by a small molecule.
Bioorg Med Chem Lett 22: 5249-52 (2012)
Korea Institute Of Science And Technology
Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.
J Med Chem 55: 6888-97 (2012)
Virginia Commonwealth University
Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors.
Biochemistry 51: 6246-59 (2012)
University Of Pittsburgh
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome.
J Med Chem 55: 6629-33 (2012)
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates.
Mol Pharmacol 82: 687-699 (2014)
University Of California San Diego
Discovery of ITX 4520: a highly potent orally bioavailable hepatitis C virus entry inhibitor.
Bioorg Med Chem Lett 22: 4955-61 (2012)
Itherx Pharmaceuticals
Synthesis and biological evaluation of the 1-arylpyrazole class ofs(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).
J Med Chem 55: 8211-24 (2012)
Esteve
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
J Med Chem 55: 6948-67 (2012)
Universit£
Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.
Bioorg Med Chem Lett 22: 4926-9 (2012)
University Of Mississippi
Predicting new indications for approved drugs using a proteochemometric method.
J Med Chem 55: 6832-48 (2012)
Georgetown University Medical Center
Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders.
J Med Chem 55: 9045-54 (2012)
Pfizer
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
J Med Chem 55: 6898-915 (2012)
Universit£
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile.
J Med Chem 55: 6916-33 (2012)
Astrazeneca
Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity.
ACS Med Chem Lett 2: 929-932 (2011)
TBA
Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5a-reductase inhibitors: a legitimate approach.
Eur J Med Chem 54: 728-39 (2012)
Panjab University
Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.
J Nat Prod 75: 1400-4 (2012)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.
J Med Chem 55: 6776-83 (2012)
Istituto Di Biostrutture E Bioimmagini-Cnr
Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2.
J Med Chem 55: 6822-31 (2012)
Academy Of Sciences Of The Czech Republic
Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor.
Bioorg Med Chem 20: 4760-73 (2012)
Indiana University
An efficient synthesis of 3-OBn-6ß,14-epoxy-bridged opiates from naltrexone and identification of a related dual MOR inverse agonist/KOR agonist.
Bioorg Med Chem Lett 22: 6801-5 (2012)
University Of New England
Discovery of MEK/PI3K dual inhibitor via structure-based virtual screening.
Bioorg Med Chem Lett 22: 4946-50 (2012)
Sejong University
Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine.
Bioorg Med Chem Lett 22: 4990-3 (2012)
Washington University
Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
Bioorg Med Chem Lett 22: 5025-30 (2012)
University Of Illinois At Chicago
The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents.
Bioorg Med Chem Lett 22: 5093-7 (2012)
Virginia Commonwealth University
Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay.
Eur J Med Chem 61: 41-8 (2013)
Martin-Luther-University Halle-Wittenberg
The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.
Eur J Med Chem 54: 740-9 (2012)
University Of Thessaly
Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.
Eur J Med Chem 61: 61-72 (2013)
Palack£
Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.
Eur J Med Chem 54: 771-83 (2012)
Virginia Commonwealth University
Novel trisubstituted harmine derivatives with original in vitro anticancer activity.
J Med Chem 55: 6489-501 (2012)
University Of Namur (Fundp)
3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
J Med Chem 55: 6866-80 (2012)
Astrazeneca
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.
Bioorg Med Chem 20: 4635-45 (2012)
Abbott Laboratories
Synthesis and SAR studies of bicyclic amine series GPR119 agonists.
Bioorg Med Chem Lett 22: 5123-8 (2012)
Sanwa Kagaku Kenkyusho
Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors.
Bioorg Med Chem Lett 22: 5114-7 (2012)
Pfizer
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg Med Chem Lett 22: 4967-74 (2012)
Amgen
The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 22: 4979-85 (2012)
Exelixis
Discovery and optimization of novel purines as potent and selective CB2 agonists.
Bioorg Med Chem Lett 22: 4962-6 (2012)
Eli Lilly
Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors.
Bioorg Med Chem Lett 22: 4998-5002 (2012)
Janssen Infectious Diseases-Diagnostics
Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells.
J Med Chem 55: 6306-15 (2012)
Mcgill University
Targeting Tumour Proliferation with a Small-Molecule Inhibitor of AICAR Transformylase Homodimerization.
Chembiochem 13: 1628-34 (2012)
University Of Southampton
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem 20: 4680-92 (2012)
Takeda Pharmaceutical
Oxoquinoline acyclonucleoside phosphonate analogues as a new class of specific inhibitors of human immunodeficiency virus type 1.
Bioorg Med Chem Lett 22: 5055-8 (2012)
Universidade Federal Fluminense
Conformationally-locked N-glycosides with selectiveß-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.
J Med Chem 55: 6857-65 (2012)
Universitat Rovira I Virgili
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
J Appl Toxicol 32: 858-66 (2012)
Jagiellonian University
Identification of Type-II Inhibitors Using Kinase Structures.
Chem Biol Drug Des 80: 657-64 (2012)
Pfizer
Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose.
J Nat Prod 75: 1383-92 (2012)
University Of Kentucky
S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase.
ACS Med Chem Lett 3: 15-19 (2012)
TBA
Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity.
Chembiochem 13: 1584-93 (2012)
Yonsei University
Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver.
Drug Metab Dispos 40: 1917-26 (2012)
Toyama Prefectural University
Methylation of imidazoline related compounds leads to loss ofa2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands.
Bioorg Med Chem 20: 4710-5 (2012)
University Of Strasburg
¿-amino-ß-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.
Bioorg Med Chem 20: 4716-26 (2012)
Insa De Rouen And Universit£
Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists.
Bioorg Med Chem 20: 4661-7 (2012)
China Pharmaceutical University
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.
Bioorg Med Chem Lett 22: 5035-40 (2012)
Vanderbilt University Medical Center
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors.
Bioorg Med Chem Lett 22: 5108-13 (2012)
Xenon Pharmaceuticals
Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors.
Bioorg Med Chem Lett 22: 5067-70 (2012)
Daiichi Sankyo
Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists.
Bioorg Med Chem Lett 22: 4951-4 (2012)
Toray Industries
Structure-based optimization of oxadiazole-based GSK-3 inhibitors.
Eur J Med Chem 61: 26-40 (2013)
Technische Universit£T Darmstadt
Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents.
Eur J Med Chem 54: 647-59 (2012)
Georgia State University
Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.
Eur J Med Chem 54: 483-98 (2012)
University Of Strathclyde
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem Lett 22: 4986-9 (2012)
Bristol-Myers Squibb
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
Bioorg Med Chem Lett 22: 5031-4 (2012)
University Of Hamburg
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Ka and mTOR.
Bioorg Med Chem Lett 22: 5098-103 (2012)
Pfizer
Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.
Eur J Med Chem 54: 660-8 (2012)
Boehringer Ingelheim Rcv
Design and synthesis of novel p38a MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety.
Bioorg Med Chem Lett 22: 5118-22 (2012)
Toray Industries
Synthesis and in vitro evaluation of [18F](R)-FEPAQ: a potential PET ligand for VEGFR2.
Bioorg Med Chem Lett 22: 5104-7 (2012)
Columbia University College Of Physicians And Surgeons
Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor.
Bioorg Med Chem Lett 22: 5089-92 (2012)
Targacept
Wake-promoting agents: search for next generation modafinil: part IV.
Eur J Med Chem 54: 949-51 (2012)
Cephalon (France)
Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluation.
Eur J Med Chem 61: 2-25 (2013)
Institut Curie
Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators.
Bioorg Med Chem 20: 4727-36 (2012)
Insa Lyon
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D1 receptor.
Bioorg Med Chem 20: 4862-71 (2012)
Shenyang Pharmaceutical University
Total synthesis of grassystatin A, a probe for cathepsin E function.
Bioorg Med Chem 20: 4774-80 (2012)
Fudan University
Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones.
Bioorg Med Chem 20: 4737-43 (2012)
Ghent University
Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.
J Med Chem 55: 6149-61 (2012)
University Of Michigan
Design, synthesis, and biological evaluation of nonsteroidal cycloalkane[d]isoxazole-containing androgen receptor modulators.
J Med Chem 55: 6316-27 (2012)
University Of Eastern Finland
Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.
J Med Chem 55: 7104-13 (2012)
University Of Gothenburg
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
J Med Chem 55: 6700-15 (2012)
Teijin Pharma
Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.
J Med Chem 55: 6738-50 (2012)
Emory University
Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups.
Bioorg Med Chem 20: 4838-47 (2012)
Universidad De Santiago De Compostela
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.
Bioorg Med Chem Lett 22: 5071-4 (2012)
Kitasato University
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem 55: 6363-74 (2012)
Astrazeneca
Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine.
J Med Chem 55: 6512-22 (2012)
Research Triangle Institute
Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors.
J Med Chem 55: 9120-35 (2012)
Seoul National University
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Bioorg Med Chem 20: 4217-25 (2012)
Duquesne University
Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.
Bioorg Med Chem 20: 4422-9 (2012)
Washington University
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein.
Bioorg Med Chem 20: 4194-200 (2012)
Soochow University
Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors.
Bioorg Med Chem 20: 4237-44 (2012)
Kurukshetra University
Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with ??-adrenoceptor antagonistic properties.
Bioorg Med Chem 20: 4245-57 (2012)
Jagiellonian University Medical College
Contribution of indazolinone tautomers to kinase activity.
Bioorg Med Chem Lett 22: 4502-5 (2012)
Abbott Laboratories
Assay and inhibition of diacylglycerol lipase activity.
Bioorg Med Chem Lett 22: 4585-92 (2012)
Northeastern University
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.
Bioorg Med Chem Lett 22: 5084-8 (2012)
Vanderbilt University Medical Center
Discovery of novel PI3K¿/d inhibitors as potential agents for inflammation.
Bioorg Med Chem Lett 22: 4546-9 (2012)
Cellzome
'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.
Bioorg Med Chem Lett 22: 4693-6 (2012)
Universit£
New farnesyltransferase inhibitors in the phenothiazine series.
Bioorg Med Chem Lett 22: 4517-22 (2012)
Al. I. Cuza University Of Iasi
Structure-based optimization of aminopyridines as PKC¿ inhibitors.
Bioorg Med Chem Lett 22: 4645-9 (2012)
Vertex Pharmaceuticals
CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.
Bioorg Med Chem Lett 22: 4540-5 (2012)
Chinese Academy Of Sciences
Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.
Bioorg Med Chem Lett 22: 4550-4 (2012)
University Of Li£Ge
Antidiabetic compounds from Sarracenia purpurea used traditionally by the Eeyou Istchee Cree First Nation.
J Nat Prod 75: 1284-8 (2012)
University Of Ottawa
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
J Med Chem 55: 6375-80 (2012)
Universit£
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
J Med Chem 55: 6391-402 (2012)
University Of Lille
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.
J Med Chem 55: 6608-23 (2012)
Universit£
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
J Med Chem 55: 6467-77 (2012)
University Of North Carolina At Chapel Hill
Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.
ACS Med Chem Lett 3: 490-495 (2012)
TBA
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
J Med Chem 55: 6523-40 (2012)
Amgen
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
J Med Chem 55: 6554-65 (2012)
Massachusetts General Hospital
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants.
J Med Chem 55: 6352-62 (2012)
Memorial Sloan-Kettering Cancer Center
Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor.
Bioorg Med Chem Lett 22: 4719-22 (2012)
Bristol-Myers Squibb R & D
Virtual screening identifies novel sulfonamide inhibitors of ecto-5'-nucleotidase.
J Med Chem 55: 6576-81 (2012)
Rheinische Friedrich-Wilhelms-Universit£T
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).
Bioorg Med Chem 20: 4290-302 (2012)
The State University Of New York
Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: new lead exhibits a distinct binding mode.
Bioorg Med Chem 20: 4303-9 (2012)
National Cancer Institute
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1.
Bioorg Med Chem Lett 22: 4723-7 (2012)
Bristol-Myers Squibb Research & Development
Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors.
Bioorg Med Chem Lett 22: 4740-4 (2012)
University Of South Florida
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.
Bioorg Med Chem Lett 22: 4599-604 (2012)
Astrazeneca
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.
Bioorg Med Chem Lett 22: 4532-5 (2012)
Vanderbilt University School Of Medicine
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Bioorg Med Chem Lett 22: 4528-31 (2012)
Abbott Laboratories
Synthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPAR¿ modulators.
Eur J Med Chem 54: 522-33 (2012)
Daiichi Sankyo
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents.
Eur J Med Chem 54: 512-21 (2012)
Instituto De Tecnologia Em F£Rmacos - Farmanguinhos
Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold.
Bioorg Med Chem 20: 4201-7 (2012)
Cardiff University
Design, synthesis and biological activity of 6-substituted carbamoyl benzimidazoles as new nonpeptidic angiotensin II AT1 receptor antagonists.
Bioorg Med Chem 20: 4208-16 (2012)
School Of Chemical Engineering & The Environment
Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4-oxadiazole derivatives based on Vanillic acid as potential immunosuppressive agents.
Bioorg Med Chem 20: 4226-36 (2012)
Nanjing University
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.
Bioorg Med Chem Lett 22: 4561-6 (2012)
Daiichi Sankyo
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem Lett 22: 4654-9 (2012)
National Health Research Institutes
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position.
Bioorg Med Chem Lett 22: 4640-4 (2012)
Kobe Gakuin University
Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype.
Bioorg Med Chem Lett 22: 4660-4 (2012)
Actelion Pharmaceuticals
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.
Bioorg Med Chem Lett 22: 4613-8 (2012)
Cellzome
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV.
Bioorg Med Chem Lett 22: 4839-43 (2012)
Astrazeneca
Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase.
Chem Biol 19: 721-30 (2012)
Albert Einstein College Of Medicine
Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents.
Chem Biol Drug Des 80: 616-624 (2012)
Central Institute Of Medicinal And Aromatic Plants
Synthesis and Biological Evaluation of 3-thiazolocoumarinyl Schiff-base Derivatives as Cholinesterase Inhibitors.
Chem Biol Drug Des 80: 605-15 (2012)
Comsats Institute Of Information Technology
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
J Med Chem 55: 6209-23 (2012)
Academy Of Sciences Of The Czech Republic
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
J Med Chem 55: 6639-43 (2012)
University Of Oxford
Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.
J Med Chem 55: 6624-8 (2012)
University Of Southern Denmark
A new class of highly potent and selective endomorphin-1 analogues containinga-methylene-ß-aminopropanoic acids (map).
J Med Chem 55: 6224-36 (2012)
Lanzhou University
Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors.
Bioorg Med Chem 20: 4323-9 (2012)
Academy Of Military Medical Sciences
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.
Bioorg Med Chem Lett 22: 4681-5 (2012)
Ecole Nationale Sup£Rieure De Chimie De Montpellier
Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.
J Med Chem 55: 6342-51 (2012)
University Of Washington
1,2,3-Triazole-containing uracil derivatives with excellent pharmacokinetics as a novel class of potent human deoxyuridine triphosphatase inhibitors.
J Med Chem 55: 6427-37 (2012)
Taiho Pharmaceutical
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
J Med Chem 55: 6634-8 (2012)
Sapienza University Of Rome
Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.
J Med Chem 55: 6502-11 (2012)
Universit£
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
J Med Chem 55: 5965-81 (2012)
The University Of Illinois At Chicago
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
Drug Metab Dispos 40: 1834-45 (2012)
Vanderbilt University Medical Center
Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.
J Med Chem 55: 6124-36 (2012)
Leipzig University
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
J Med Chem 55: 6328-41 (2012)
Sanford-Burnham Medical Research Institute
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes.
J Med Chem 55: 6137-48 (2012)
Merck Research Laboratories
Lead optimization of antimalarial propafenone analogues.
J Med Chem 55: 6087-93 (2012)
St. Jude Children'S Research Hospital
Kinetic studies of novel inhibitors of endomorphin degrading enzymes.
Med Chem Res 21: 1445-1450 (2012)
TBA
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives.
Bioorg Med Chem 20: 4336-47 (2012)
North-West University
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.
Bioorg Med Chem 20: 4371-6 (2012)
Imperial College
Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.
Bioorg Med Chem 21: 1555-63 (2013)
Superacide Et Chimie Des Syst£Mes£
Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity.
Bioorg Med Chem 20: 4430-6 (2012)
Nanjing University
Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.
Bioorg Med Chem Lett 22: 4707-12 (2012)
University Of Waterloo
Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Bioorg Med Chem Lett 22: 4864-8 (2012)
Emory University
Design, synthesis and biological evaluation ofß-carboline derivatives as novel inhibitors targeting B-Raf kinase.
Bioorg Med Chem Lett 22: 4783-6 (2012)
China Pharmaceutical University
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Bioorg Med Chem Lett 22: 4907-11 (2012)
Astrazeneca
New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714.
Eur J Med Chem 54: 439-46 (2012)
Instituto Cajal (Csic)
In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-¿-pyrone skeleton.
Eur J Med Chem 54: 914-8 (2012)
Universidade Do Porto
Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes.
Bioorg Med Chem 20: 4377-89 (2012)
Link£Ping University
Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors.
Bioorg Med Chem 20: 4405-12 (2012)
Xi'An Jiaotong University
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J Med Chem 55: 6176-93 (2012)
Genentech
N'-substituted-2'-O,3'-N-carbonimidoyl bridged macrolides: novel anti-inflammatory macrolides without antimicrobial activity.
J Med Chem 55: 6111-23 (2012)
Glaxosmithkline
Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.
Drug Metab Dispos 40: 1797-802 (2012)
University Of Kansas
Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus.
Bioorg Med Chem 20: 4437-42 (2012)
Kumamoto University
Identification of a duald OR antagonist/µ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).
Bioorg Med Chem Lett 22: 4869-72 (2012)
Janssen Research And Development
Inhibition of therapeutically important polymerases with high affinity bis-intercalators.
Bioorg Med Chem Lett 22: 4844-8 (2012)
University Of Missouri
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Bioorg Med Chem Lett 22: 4750-5 (2012)
Abbott Laboratories
Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.
J Nat Prod 75: 1210-4 (2012)
Fundacion Medina
Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.
J Med Chem 55: 5942-50 (2012)
San Francisco State University
An ultrahigh affinity d-peptide antagonist Of MDM2.
J Med Chem 55: 6237-41 (2012)
University Of Maryland
Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.
J Med Chem 55: 5749-59 (2012)
National Institute Of Biological Sciences
Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).
J Med Chem 55: 5951-64 (2012)
Astrazeneca
Structure and bioassay of triterpenoids and steroids isolated from Sinocalamus affinis.
J Nat Prod 75: 1160-6 (2012)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Simple Pseudo-dipeptides with a P2' Glutamate: A NOVEL INHIBITOR FAMILY OF MATRIX METALLOPROTEASES AND OTHER METZINCINS.
J Biol Chem 287: 26647-56 (2012)
Commissariat Á
Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.
Drug Metab Dispos 40: 1778-84 (2012)
Diakonhjemmet Hospital
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.
Bioorg Med Chem Lett 22: 4896-9 (2012)
Albany Molecular Research, Inc. (Amri)
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: vidalol B.
Eur J Med Chem 54: 423-8 (2012)
Atat£Rk University
Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata.
Org Med Chem Lett 2: 21 (2012)
University Of The West Indies
Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F.
J Med Chem 55: 5982-6 (2012)
University Of Bonn
Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.
Drug Metab Dispos 40: 1765-70 (2012)
University Of Michigan
Design, synthesis and structure-activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists.
Bioorg Med Chem Lett 22: 4756-61 (2012)
Eisai
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.
Eur J Med Chem 54: 311-23 (2012)
University Of Salerno
Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.
Eur J Med Chem 54: 324-42 (2012)
Piramal Healthcare
Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.
Bioorg Med Chem Lett 22: 4849-53 (2012)
Theravance
Furin inhibitors: importance of the positive formal charge and beyond.
Bioorg Med Chem 20: 4462-71 (2012)
Torrey Pines Institute For Molecular Studies
Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent.
Bioorg Med Chem 20: 4590-7 (2012)
Emory University Csi
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles.
Bioorg Med Chem 20: 4514-21 (2012)
University Of Copenhagen
Synthesis and biological evaluation of an orally active glycosylated endomorphin-1.
J Med Chem 55: 5859-67 (2012)
The University Of Queensland
Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes.
Drug Metab Dispos 40: 1757-64 (2012)
University Of Washington
Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.
Bioorg Med Chem 20: 4582-9 (2012)
University Of Alabama At Birmingham
Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors.
Bioorg Med Chem 20: 4556-63 (2012)
University Of Maryland
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.
Bioorg Med Chem Lett 22: 5134-40 (2012)
H. Lundbeck
Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction.
Bioorg Med Chem Lett 22: 4810-5 (2012)
Shionogi
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett 22: 4769-72 (2012)
Takeda Pharmaceutical
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett 22: 4281-7 (2012)
Pfizer
Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs.
Bioorg Med Chem Lett 22: 4625-8 (2012)
National Institute Of Medicinal Materials
New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.
Eur J Med Chem 54: 303-10 (2012)
Universidade Do Minho
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.
J Med Chem 55: 5720-33 (2012)
Second Military Medical University
Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.
J Med Chem 55: 5868-77 (2012)
Eberhard-Karls University
Design, synthesis and biological evaluation of novel imidazopyridines as potential antidiabetic GSK3ß inhibitors.
Bioorg Med Chem Lett 22: 4221-4 (2012)
Crystalgenomics
Potent and selective inhibitors of PI3Kd: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Bioorg Med Chem Lett 22: 4296-302 (2012)
Genentech
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.
Bioorg Med Chem 21: 1564-9 (2013)
Universit£
Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship.
Bioorg Med Chem Lett 22: 4273-80 (2012)
Chemical Diversity Research Institute
Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain.
J Nat Prod 75: 1108-16 (2012)
China Pharmaceutical University
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
ACS Med Chem Lett 3: 402-406 (2012)
TBA
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett 3: 129-134 (2012)
TBA
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Drug Metab Dispos 40: 1736-43 (2012)
Gdansk University Of Technology
Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase.
Bioorg Med Chem Lett 22: 4341-7 (2012)
Advinus Therapeutics
Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter.
Bioorg Med Chem Lett 22: 4303-6 (2012)
Beijing Normal University
Natural products as a gold mine for selective matrix metalloproteinases inhibitors.
Bioorg Med Chem 20: 4164-71 (2012)
East China University Of Science And Technology
C-Aryl 5a-carba-ß-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem 20: 4117-27 (2012)
Chugai Pharmaceutical
Beta-carboline alkaloids derived from the ascidian Synoicum sp.
Bioorg Med Chem 20: 4082-7 (2012)
Seoul National University
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.
Eur J Med Chem 54: 232-8 (2012)
Southern Medical University
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins.
Bioorg Med Chem Lett 22: 4307-9 (2012)
Rwth Aachen University
Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.
J Med Chem 55: 5774-83 (2012)
Universit£
Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
J Med Chem 55: 5088-109 (2012)
Pfizer
Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C.
J Nat Prod 75: 1058-62 (2012)
Chinese Academy Of Sciences
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
J Med Chem 55: 6645-68 (2012)
University Of Southern California
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.
J Med Chem 55: 6162-75 (2012)
Bristol-Myers Squibb
Design and synthesis of a novel series of bicyclic heterocycles as potent¿-secretase modulators.
J Med Chem 55: 9089-106 (2012)
Janssen Pharmaceutical Companies Of Johnson & Johnson
Substrate analog studies of the ?-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.
Bioorg Med Chem 20: 4064-81 (2012)
University Of California San Francisco
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹?F-PET imaging agents for ?-amyloid plaques.
Bioorg Med Chem Lett 22: 4332-7 (2012)
Astrazeneca
Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors.
Eur J Med Chem 54: 264-71 (2012)
Universidade Federal Do Rio De Janeiro
Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening.
Eur J Med Chem 54: 188-96 (2012)
East China University Of Science And Technology
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.
J Med Chem 55: 5734-48 (2012)
National Center For Advancing Translation Sciences
Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor: INHIBITION OF TAUTOMERASE AND PROINFLAMMATORY ACTIVITIES OF MACROPHAGE MIGRATION INHIBITORY FACTOR.
J Biol Chem 287: 24844-61 (2012)
Council Of Scientific And Industrial Research (Csir) Indian Institute Of Chemical Biology
Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
Drug Metab Dispos 40: 1686-97 (2012)
Pfizer
Langkolide, a 32-membered macrolactone antibiotic produced by Streptomyces sp. Acta 3062.
J Nat Prod 75: 1018-24 (2012)
Technische Universit£T Berlin
Structure-activity relationship study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterizatio
J Med Chem 55: 5826-40 (2012)
Wayne State University
Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.
J Med Chem 55: 5933-41 (2012)
University Of Illinois At Chicago
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
J Med Chem 55: 5760-73 (2012)
Kyoto Prefectural University Of Medicine
Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.
J Med Chem 55: 5922-32 (2012)
Eisai
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.
Eur J Med Chem 54: 272-80 (2012)
Sichuan University
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.
Bioorg Med Chem Lett 22: 4404-9 (2012)
Arena Pharmaceuticals
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.
Bioorg Med Chem Lett 22: 4462-6 (2012)
Sun Yat-Sen University
Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erba.
Bioorg Med Chem Lett 22: 4413-7 (2012)
The Scripps Research Institute
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants.
Eur J Med Chem 54: 144-58 (2012)
University Of Kragujevac
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.
Bioorg Med Chem Lett 22: 4377-85 (2012)
Myrexis
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.
Bioorg Med Chem Lett 22: 4410-2 (2012)
Purdue University
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.
Bioorg Med Chem Lett 22: 4396-403 (2012)
Merck Serono
Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.
J Med Chem 55: 6689-99 (2012)
National Institute On Drug Abuse-Intramural Research Program
Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds.
J Enzyme Inhib Med Chem 28: 816-23 (2013)
University Of Life Sciences
Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach.
J Enzyme Inhib Med Chem 28: 824-9 (2013)
Ondokuz Mayis University
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles.
Eur J Med Chem 54: 95-102 (2012)
University Of Namur (Fundp)
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²¿ channel blockers with analgesic activity.
Bioorg Med Chem 20: 4128-39 (2012)
Abbott Laboratories
Discovery of novel PI3-kinased specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
J Med Chem 55: 5887-900 (2012)
Genentech
Structure-activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity.
J Med Chem 55: 5614-26 (2012)
Kyoto University
AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development.
J Med Chem 55: 4934-5 (2012)
University Of Michigan Comprehensive Cancer Center
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
J Med Chem 55: 5231-42 (2012)
Universit£T Regensburg
Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations.
J Med Chem 55: 5784-96 (2012)
National Hellenic Research Foundation
Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.
J Med Chem 55: 5591-600 (2012)
University Of Manchester
¹²5I-radiolabeled morpholine-containing arginine-glycine-aspartate (RGD) ligand ofavß3 integrin as a molecular imaging probe for angiogenesis.
J Med Chem 55: 5024-33 (2012)
University Of Florence
Irreversible protein kinase inhibitors: balancing the benefits and risks.
J Med Chem 55: 6243-62 (2012)
Covalution Pharma
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.
J Med Chem 55: 5841-50 (2012)
University Of Leeds
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.
Bioorg Med Chem Lett 22: 3890-4 (2012)
Scripps Florida
Synthesis of constrained benzocinnolinone analogues of CEP-26401 (irdabisant) as potent, selective histamine H3 receptor inverse agonists.
Bioorg Med Chem Lett 22: 4198-202 (2012)
Cephalon
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.
J Med Chem 55: 5270-90 (2012)
Ludwig Center For Cancer Research Of The University Of Lausanne
Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen.
Drug Metab Dispos 40: 1460-5 (2012)
Pacific University Oregon
Novel Cruzain Inhibitors for the Treatment of Chagas' Disease.
Chem Biol Drug Des 80: 398-405 (2012)
University Of California San Diego
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.
J Med Chem 55: 5003-12 (2012)
Astrazeneca
Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect.
J Med Chem 55: 6094-110 (2012)
Philipps University Marburg
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38a MAP kinase inhibitor for the treatment of inflammatory diseases.
Bioorg Med Chem Lett 22: 3879-83 (2012)
Astrazeneca
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity.
Bioorg Med Chem Lett 22: 3895-9 (2012)
Astrazeneca
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
Bioorg Med Chem Lett 22: 3873-8 (2012)
Astrazeneca
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett 22: 3946-50 (2012)
Bristol-Myers Squibb Research
Synthesis and evaluation of 11ß-(4-substituted phenyl) estradiol analogs: transition from estrogen receptor agonists to antagonists.
Bioorg Med Chem 20: 3768-80 (2012)
Northeastern University
5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebrala7-nAChR in mice.
Bioorg Med Chem 20: 3698-702 (2012)
The Johns Hopkins University School Of Medicine
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.
Eur J Med Chem 54: 123-36 (2012)
Shanghai Institute Of Pharmaceutical Industry
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett 22: 3951-6 (2012)
Bristol-Myers Squibb Research
Towards a KCC2 blocker pharmacophore model.
Bioorg Med Chem Lett 22: 3978-82 (2012)
Ucb Pharma
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Bioorg Med Chem 20: 3728-41 (2012)
Gazi University
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors.
Bioorg Med Chem 20: 3807-15 (2012)
Shandong University
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Biochemistry 51: 4868-79 (2012)
The University Of Auckland
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.
Bioorg Med Chem Lett 22: 4059-63 (2012)
The University Of Sydney
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.
Bioorg Med Chem Lett 22: 4038-43 (2012)
University Of Texas Medical Branch
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
Bioorg Med Chem Lett 22: 4163-8 (2012)
Astrazeneca
Identification of chalcones as potent and selective PDE5A1 inhibitors.
Bioorg Med Chem Lett 22: 3983-7 (2012)
Youai
Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.
Bioorg Med Chem Lett 22: 3916-20 (2012)
The Scripps Research Institute
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.
Bioorg Med Chem Lett 22: 3988-92 (2012)
University Of Lille
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.
Bioorg Med Chem Lett 22: 3921-5 (2012)
Vanderbilt University Medical Center
MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.
Bioorg Med Chem Lett 22: 3941-5 (2012)
Merck Research Laboratories
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT(1A) receptors.
Bioorg Med Chem Lett 22: 3967-72 (2012)
University Of Belgrade
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
Bioorg Med Chem Lett 22: 4033-7 (2012)
Biogen Idec
N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration.
Bioorg Med Chem Lett 22: 3884-9 (2012)
Astrazeneca
Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.
J Nat Prod 75: 1051-7 (2012)
University Of Southampton Faculty Of Medicine
Kallikrein protease activated receptor (PAR) axis: an attractive target for drug development.
J Med Chem 55: 6669-86 (2012)
Universit£
Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy.
J Med Chem 55: 5483-96 (2012)
Taiho Pharmaceutical
Non-iminosugar glucocerebrosidase small molecule chaperones.
Medchemcomm 3: 56-60 (2012)
National Human Genome Research Institute
Discovery of novel EGFR tyrosine kinase inhibitors by structure-based virtual screening.
Bioorg Med Chem Lett 22: 4004-9 (2012)
East China University Of Science And Technology
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg Med Chem Lett 22: 4089-93 (2012)
Amgen
N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases.
Bioorg Med Chem Lett 22: 3993-7 (2012)
University Of Lisbon
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem Lett 22: 4064-7 (2012)
Yale University
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1).
Bioorg Med Chem Lett 22: 3935-40 (2012)
Pharmaxis
A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779.
J Med Chem 55: 5243-54 (2012)
Cephalon
Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configurational assignment using infrared and vibrational circ
J Med Chem 55: 5403-12 (2012)
University Of Copenhagen
Potent inhibition of human sulfotransferase 1A1 by 17a-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity.
Drug Metab Dispos 40: 1588-95 (2012)
University Of Alabama At Birmingham
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening.
Bioorg Med Chem Lett 22: 4023-7 (2012)
S*Bio
Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V.
Eur J Med Chem 54: 10-21 (2012)
Universidade Federal De S£O Carlos
Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.
J Med Chem 55: 5536-45 (2012)
Genentech
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
J Med Chem 55: 5901-21 (2012)
Argenta Discovery
Impacts of some antibiotics on human serum paraoxonase 1 activity.
J Enzyme Inhib Med Chem 28: 758-64 (2013)
Atatürk University
Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).
J Med Chem 55: 4605-18 (2012)
University Of Berne
Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: INHIBITION AND POTENTIATION OF CYS-LOOP RECEPTOR SIGNALING THROUGH A CONSERVED TRANSMEMBRANE INTERSUBUNIT SITE.
J Biol Chem 287: 25241-54 (2012)
University Of Copenhagen
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Drug Metab Dispos 40: 1641-8 (2012)
Bristol-Myers Squibb
Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor.
J Med Chem 55: 5255-69 (2012)
Eisai
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors.
Eur J Med Chem 53: 346-55 (2012)
Universidad Aut£Noma Del Estado De Morelos
Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors.
Bioorg Med Chem 20: 3746-55 (2012)
Nanjing University
E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.
Bioorg Med Chem Lett 22: 3962-6 (2012)
The University Of Tokyo
Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.
Bioorg Med Chem Lett 22: 3973-7 (2012)
Glaxosmithkline
Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme.
J Med Chem 55: 5582-90 (2012)
Technical University Of Denmark
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.
J Med Chem 55: 4978-89 (2012)
Trinity College
Hydrophobic Interactions Improve Selectivity to ERa for Ben-zothiophene SERMs.
ACS Med Chem Lett 3: 207-210 (2012)
TBA
Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
Bioorg Med Chem 20: 3816-27 (2012)
Peking University
Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C.
Bioorg Med Chem 20: 3915-24 (2012)
Universit£
Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors.
Bioorg Med Chem Lett 22: 4044-8 (2012)
Korea Research Institute Of Chemical Technology
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Bioorg Med Chem Lett 22: 4028-32 (2012)
Glaxosmithkline
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.
Bioorg Med Chem Lett 22: 4094-9 (2012)
Korea University
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.
Bioorg Med Chem Lett 22: 4153-8 (2012)
Zalicus Pharmaceuticals
Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives.
Bioorg Med Chem Lett 22: 4122-6 (2012)
Korea Institute Of Science And Technology
Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities.
Bioorg Med Chem Lett 22: 4159-62 (2012)
Hanyang University
Microwave assisted synthesis of spirocyclic pyrrolidines -s1 receptor ligands with modified benzene-N-distance.
Eur J Med Chem 53: 327-36 (2012)
Institut F£R Pharmazeutische Und Medizinische Chemie
Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists.
Bioorg Med Chem 20: 3880-6 (2012)
Cephalon
Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis.
Bioorg Med Chem Lett 22: 4179-81 (2012)
Chinese Academy Of Sciences
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Bioorg Med Chem Lett 22: 4133-8 (2012)
Merck Research Laboratories
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targetinga5ß1: part 1.
Bioorg Med Chem Lett 22: 4111-6 (2012)
Astrazeneca
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.
Eur J Med Chem 53: 229-34 (2012)
Fudan University
Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.
J Med Chem 55: 5337-49 (2012)
Korea Advanced Institute Of Science And Technology (Kaist)
Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding.
J Med Chem 55: 5121-9 (2012)
University Of Minnesota Health Sciences Center
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonists.
J Med Chem 55: 5061-76 (2012)
F. Hoffmann-La Roche
Structure guided P1' modifications of HEA derivedß-secretase inhibitors for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett 22: 3607-11 (2012)
Envoy Therapeutics
Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents.
Bioorg Med Chem Lett 22: 3589-93 (2012)
Nanjing University
Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists.
Bioorg Med Chem Lett 22: 4148-52 (2012)
Corning
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targetinga5ß1: part 2.
Bioorg Med Chem Lett 22: 4117-21 (2012)
Astrazeneca
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB1 receptor.
J Med Chem 55: 5627-31 (2012)
Sapienza University Of Rome
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
Chembiochem 13: 1291-6 (2012)
Frederick National Laboratory For Cancer Research
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists.
J Med Chem 55: 5380-90 (2012)
Universit£
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.
Bioorg Med Chem 20: 3429-45 (2012)
Universit£
Activity landscape modeling of PPAR ligands with dual-activity difference maps.
Bioorg Med Chem 20: 3523-32 (2012)
Universidad Nacional Aut£Noma De M£Xico
Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase.
J Med Chem 55: 4580-93 (2012)
Cephalon
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.
J Med Chem 55: 4640-51 (2012)
University Of Wisconsin-Milwaukee
A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design.
J Med Chem 55: 5311-25 (2012)
Radboud University Nijmegen Medical Centre
Radiosynthesis of a¹8F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo.
Bioorg Med Chem 20: 3410-21 (2012)
Helmholtz-Zentrum Dresden-Rossendorf
2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.
Eur J Med Chem 53: 254-63 (2012)
Technische Universit£T Braunschweig
Discovery and evaluation of selective N-type calcium channel blockers: 6-unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives.
Bioorg Med Chem Lett 22: 3639-42 (2012)
Ajinomoto Pharmaceuticals
Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.
Bioorg Med Chem Lett 22: 3643-7 (2012)
Takeda Pharmaceutical
Discovery of XL413, a potent and selective CDC7 inhibitor.
Bioorg Med Chem Lett 22: 3727-31 (2012)
Exelixis
Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides.
Bioorg Med Chem Lett 22: 3693-8 (2012)
Vertex Pharmaceuticals
Use of libraries to access new chemical space: applications to CRTH2.
Bioorg Med Chem Lett 22: 3682-7 (2012)
Pfizer
Synthesis and SAR of tetrahydroisoquinolines as Rev-erba agonists.
Bioorg Med Chem Lett 22: 3739-42 (2012)
The Scripps Research Institute
Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors.
J Med Chem 55: 4872-6 (2012)
University Of Gothenburg
Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.
J Med Chem 55: 4847-60 (2012)
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and in vitro characterization of trans- and cis-[(18)F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-D-aspartate receptor.
Eur J Med Chem 53: 408-15 (2012)
Institute Of Biomedical Imaging (I2Bm)
Discovery of pyrroloaminopyrazoles as novel PAK inhibitors.
J Med Chem 55: 4728-39 (2012)
Pfizer
Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.
Bioorg Med Chem Lett 22: 3800-6 (2012)
Syngenta Crop Protection Muenchwilen
Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses.
Bioorg Med Chem Lett 22: 3688-92 (2012)
Chosun University
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Leukemia 26: 2326-35 (2012)
Celgene
Automated generation of turn mimetics: proof of concept study for the MC4 receptor.
Bioorg Med Chem 20: 3565-74 (2012)
Neurocrine Biosciences
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.
Bioorg Med Chem 20: 3575-83 (2012)
Zafes/Liff/Osf Goethe-University Frankfurt
Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
J Med Chem 55: 5130-42 (2012)
Astrazeneca
Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: potent and selective CB2 cannabinoid receptor inverse agonists.
J Med Chem 55: 5391-402 (2012)
Universit£
Rapid identification of a novel small molecule phosphodiesterase 10A (PDE10A) tracer.
J Med Chem 55: 4776-87 (2012)
Amgen
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem 55: 5188-219 (2012)
Amgen
Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase¿ inhibitors.
J Med Chem 55: 5467-82 (2012)
Exelixis
Wake promoting agents: search for next generation modafinil, lessons learned: part III.
Bioorg Med Chem Lett 22: 3751-3 (2012)
Cephalon
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
Bioorg Med Chem Lett 22: 3795-9 (2012)
Pfizer
Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism.
Bioorg Med Chem Lett 22: 3656-60 (2012)
Seoul National University
Synthesis and evaluation of¿-lactam analogs of PGE2 as EP4 and EP2/EP4 agonists.
Bioorg Med Chem 20: 3502-22 (2012)
Minase Research Institute
Recent developments and biological activities of thiazolidinone derivatives: a review.
Bioorg Med Chem 20: 3378-95 (2012)
Dr. Hari Singh Gour University
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors.
J Enzyme Inhib Med Chem 28: 717-26 (2013)
Shandong University
Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors.
J Enzyme Inhib Med Chem 28: 747-52 (2013)
East China University Of Science And Technology
Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors as Potential Antifungals.
ACS Chem Biol 7: 1257-67 (2012)
Technische UniversitÄT Dortmund
Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.
J Med Chem 55: 5361-79 (2012)
Astrazeneca
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Bioorg Med Chem Lett 22: 3671-5 (2012)
Eli Lilly
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.
Bioorg Med Chem Lett 22: 3807-9 (2012)
Clermont Universit£
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase.
Bioorg Med Chem 20: 3658-65 (2012)
Kobe Pharmaceutical University
Discovery of novel indane derivatives as liver-selective thyroid hormone receptorß (TRß) agonists for the treatment of dyslipidemia.
Bioorg Med Chem 20: 3622-34 (2012)
Kissei Pharmaceutical
Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.
Bioorg Med Chem Lett 22: 3392-7 (2012)
Pfizer
Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease.
Eur J Med Chem 53: 13-21 (2012)
University Of Kwazulu-Natal
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards theß-exosite.
Bioorg Med Chem Lett 22: 3754-7 (2012)
Fox Chase Chemical Diversity Center
The design, synthesis, and biological evaluation of PIM kinase inhibitors.
Bioorg Med Chem Lett 22: 3732-8 (2012)
Exelixis
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.
Bioorg Med Chem Lett 22: 3781-5 (2012)
Amgen
Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11ß-HSD1 inhibitors.
Bioorg Med Chem Lett 22: 3786-90 (2012)
Amgen
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.
Eur J Med Chem 53: 390-7 (2012)
Guru Ghasidas University
A variant peptide of buffalo colostrumß-lactoglobulin inhibits angiotensin I-converting enzyme activity.
Eur J Med Chem 53: 211-9 (2012)
University Of Mysore
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
J Med Chem 55: 4740-63 (2012)
Uppsala University
Development of LC-MS/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin/orphanin FQ (NOP) receptor.
J Med Chem 55: 4955-67 (2012)
Eli Lilly
A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation.
J Med Chem 55: 4714-27 (2012)
University Hospital M£Nster
Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound.
J Med Chem 55: 5151-64 (2012)
The University Of Tokyo
Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.
Bioorg Med Chem 20: 3596-602 (2012)
Universit£
3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate.
Bioorg Med Chem 20: 3173-9 (2012)
Institute For Advanced Chemistry Of Catalonia
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.
Bioorg Med Chem Lett 22: 3437-40 (2012)
Gedeon Richter
Charting, navigating, and populating natural product chemical space for drug discovery.
J Med Chem 55: 5989-6001 (2012)
Max Planck Institute Of Molecular Physiology
Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.
J Med Chem 55: 5704-19 (2012)
University Of North Carolina At Chapel Hill
Identification of a novel family of BRAF(V600E) inhibitors.
J Med Chem 55: 5220-30 (2012)
University Of Pennsylvania
Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.
J Med Chem 55: 4189-204 (2012)
Epichem
Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.
J Med Chem 55: 4457-78 (2012)
Purdue University
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase.
Bioorg Med Chem Lett 22: 3387-91 (2012)
Array Biopharma
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo.
Eur J Med Chem 53: 190-202 (2012)
Seoul National University
Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
J Med Chem 55: 5291-310 (2012)
Arqule
Chalcogenopyrylium compounds as modulators of the ATP-binding cassette transporters P-glycoprotein (P-gp/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1).
J Med Chem 55: 4683-99 (2012)
The State University Of New York
Mitigating heterocycle metabolism in drug discovery.
J Med Chem 55: 6002-20 (2012)
Amgen
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3a.
J Med Chem 55: 4407-24 (2012)
Technische Universit£T Darmstadt
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.
J Med Chem 55: 4990-5002 (2012)
Centre Hospitalier Universitaire Vaudois (Chuv) And University Of Lausanne (Unil
In vitro hepatotoxicity and cytochrome P450 induction and inhibition characteristics of carnosic acid, a dietary supplement with antiadipogenic properties.
Drug Metab Dispos 40: 1263-7 (2012)
Amgen
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata.
Bioorg Med Chem Lett 22: 3398-401 (2012)
Griffith University
Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity.
Bioorg Med Chem Lett 22: 3412-7 (2012)
University Of Antwerp (Ua)
Tetrahydro-naphthols as orally available TRPV1 inhibitors.
Bioorg Med Chem Lett 22: 3408-11 (2012)
Bayer Yakuhin
Interaction of superoxide dismutase with the glycine zipper regions of ß-amyloid peptides: is there an implication towards Alzheimer's disease and oxidative stress?
J Enzyme Inhib Med Chem 28: 727-33 (2013)
Rhodes University
The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.
J Enzyme Inhib Med Chem 28: 741-6 (2013)
East China University Of Science And Technology
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
J Med Chem 55: 4936-54 (2012)
Amgen
Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.
J Med Chem 55: 4142-58 (2012)
Universit£
Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kß inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
J Med Chem 55: 4788-805 (2012)
Sanofi Research & Development
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
J Med Chem 55: 4244-73 (2012)
Genomics Institute Of The Novartis Research Foundation
Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam().
ACS Med Chem Lett 2: 882-884 (2011)
TBA
Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
Drug Metab Dispos 40: 1441-8 (2012)
Pfizer
Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.
Bioorg Med Chem 20: 3255-62 (2012)
Colorado State University
Conjugates of 5-isoquinolinesulfonylamides and oligo-D-arginine possess high affinity and selectivity towards Rho kinase (ROCK).
Bioorg Med Chem Lett 22: 3425-30 (2012)
University Of Tartu
Novel triazolopyridylbenzamides as potent and selective p38a inhibitors.
Bioorg Med Chem Lett 22: 3431-6 (2012)
RhôNe-Poulenc Rorer
Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents.
Bioorg Med Chem 20: 3359-67 (2012)
Nanjing University
Identification of ETP-46321, a potent and orally bioavailable PI3Ka,d inhibitor.
Bioorg Med Chem Lett 22: 3460-6 (2012)
Spanish National Cancer Research Centre (Cnio)
Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.
Eur J Med Chem 53: 124-32 (2012)
Florida A&M University
Discovery of a potent and selective GPR120 agonist.
J Med Chem 55: 4511-5 (2012)
University Of Southern Denmark
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.
Drug Metab Dispos 40: 1429-40 (2012)
Amgen
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
Bioorg Med Chem 20: 3306-16 (2012)
University Of Mansoura
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
Eur J Med Chem 53: 374-9 (2012)
University Of Belgrade
Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.
Bioorg Med Chem Lett 22: 3567-70 (2012)
The University Of Arizona
Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor.
Bioorg Med Chem Lett 22: 3441-4 (2012)
China Pharmaceutical University
Thiophene bioisosteres of spirocyclics receptor ligands: relationships between substitution pattern ands receptor affinity.
J Med Chem 55: 5350-60 (2012)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships.
J Med Chem 55: 4824-36 (2012)
Universit£
Synthesis,s1,s2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes.
Bioorg Med Chem 20: 3323-31 (2012)
National And Kapodistrian University Of Athens
Discovery of potent and orally bioavailable 17ß-hydroxysteroid dehydrogenase type 3 inhibitors.
Bioorg Med Chem 20: 3242-54 (2012)
Sumitomo Chemical
Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives.
J Enzyme Inhib Med Chem 28: 299-304 (2013)
Inonu University
Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.
J Med Chem 55: 4479-88 (2012)
Institut De Qu£Mica Avan£Ada De Catalunya (Iqac-Csic)
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.
J Med Chem 55: 4309-21 (2012)
China Pharmaceutical University
Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands.
J Med Chem 55: 4373-81 (2012)
Showa Pharmaceutical University
Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.
J Med Chem 55: 5649-75 (2012)
Zydus Research Centre
Interaction of lapatinib with cytochrome P450 3A5.
Drug Metab Dispos 40: 1414-22 (2012)
National University Of Singapore
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorg Med Chem Lett 22: 3492-7 (2012)
Perelman School Of Medicine University Of Pennsylvania
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
Bioorg Med Chem Lett 22: 3467-72 (2012)
Vanderbilt University Medical Center
The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.
Bioorg Med Chem Lett 22: 3498-502 (2012)
Novartis Institutes For Biomedical Research
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives.
Bioorg Med Chem Lett 22: 3554-9 (2012)
Second Military Medical University
Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem 20: 3263-79 (2012)
Astellas Pharma
Selective inhibition of human type-5 17ß-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis.
J Nat Prod 75: 716-21 (2012)
Gifu Pharmaceutical University
Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
J Med Chem 55: 4431-45 (2012)
University Of Manchester
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
J Med Chem 55: 4594-604 (2012)
Argenta Discovery
Structural modifications that alter the P-glycoprotein efflux properties of compounds.
J Med Chem 55: 4877-95 (2012)
Envoy Therapeutics
Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.
ACS Med Chem Lett 3: 294-298 (2012)
TBA
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists.
Bioorg Med Chem 20: 3332-58 (2012)
Takeda Pharmaceutical
The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.
Bioorg Med Chem Lett 22: 3531-4 (2012)
Glaxosmithkline
New description of protein-ligand interactions using a spherical self-organizing map.
Bioorg Med Chem 20: 5410-5 (2012)
Chugai Pharmaceutical
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.
Bioorg Med Chem Lett 22: 3544-9 (2012)
Amri
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Bioorg Med Chem Lett 22: 3535-9 (2012)
Sapienza University Of Rome
Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.
Bioorg Med Chem Lett 22: 3560-3 (2012)
Glaxosmithkline
Long-acting peptidomimetics based DPP-IV inhibitors.
Bioorg Med Chem Lett 22: 3516-21 (2012)
Zydus Research Centre
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Eur J Med Chem 52: 251-62 (2012)
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation.
J Med Chem 55: 4159-68 (2012)
Princeton University
Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).
J Med Chem 55: 4286-96 (2012)
Glaxosmithkline
Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities.
Bioorg Med Chem Lett 22: 3067-71 (2012)
Lg Life Sciences R & D Center
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: part 2.
Bioorg Med Chem Lett 22: 3163-7 (2012)
Dr. Reddy'S Laboratories
Triazoloamides as potent¿-secretase modulators with reduced hERG liability.
Bioorg Med Chem Lett 22: 3140-6 (2012)
Merck Research Laboratories
Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.
Bioorg Med Chem Lett 22: 3056-62 (2012)
Eli Lilly
Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
Bioorg Med Chem Lett 22: 3050-5 (2012)
Astrazeneca
Discovery and characterization of an inhibitor of glucosylceramide synthase.
J Med Chem 55: 4322-35 (2012)
Exelixis
Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human.
Drug Metab Dispos 40: 1345-56 (2012)
Bristol-Myers Squibb Research
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Bioorg Med Chem 20: 2845-9 (2012)
Merck Research Laboratories
Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2).
J Med Chem 55: 3934-44 (2012)
Caprotec Bioanalytics
Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.
Drug Metab Dispos 40: 1328-35 (2012)
University Of Michigan
Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.
J Med Chem 55: 3960-74 (2012)
Takeda Pharmaceutical
Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
J Med Chem 55: 4336-51 (2012)
Takeda Pharmaceutical
A 20S combined with a 22R configuration markedly increases both in vivo and in vitro biological activity of 1a,25-dihydroxy-22-methyl-2-methylene-19-norvitamin D3.
J Med Chem 55: 4352-66 (2012)
University Of Wisconsin-Madison
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein.
J Med Chem 55: 4506-10 (2012)
Universit£
Discovery of novel potent and highly selective glycogen synthase kinase-3ß (GSK3ß) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J Med Chem 55: 9107-19 (2012)
Astrazeneca
Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
Bioorg Med Chem Lett 22: 3157-62 (2012)
Dr. Reddy'S Laboratories
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists.
Bioorg Med Chem Lett 22: 3083-8 (2012)
Daiichi Sankyo
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Bioorg Med Chem Lett 22: 3063-6 (2012)
Universit£
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
Bioorg Med Chem Lett 22: 3223-8 (2012)
Glenmark Pharmaceuticals
Head-to-head prenyl tranferases: anti-infective drug targets.
J Med Chem 55: 4367-72 (2012)
University Of Illinois At Urbana-Champaign
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.
J Med Chem 55: 4297-308 (2012)
National Institute Of Diabetes And Digestive And Kidney Diseases
Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.
Eur J Med Chem 52: 284-94 (2012)
Universit£
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents.
Eur J Med Chem 52: 275-83 (2012)
Cnrs
Lead optimization of 4,4-biaryl piperidine amides as ?-secretase inhibitors.
Bioorg Med Chem Lett 22: 3203-7 (2012)
Merck Research Laboratories
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents.
Bioorg Med Chem Lett 22: 3122-5 (2012)
Sichuan University
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits.
Bioorg Med Chem 20: 2930-9 (2012)
Piramal Healthcare
Radiofluorinated histamine H3 receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation.
Bioorg Med Chem 20: 2889-96 (2012)
Eth Zurich (Swiss Federal Institute Of Technology)
Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.
Bioorg Med Chem Lett 22: 3261-4 (2012)
Sun Yat-Sen University
Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett 22: 3095-9 (2012)
Gedeon Richter
Development of rationally designed DNA N6 adenine methyltransferase inhibitors.
Bioorg Med Chem Lett 22: 3079-82 (2012)
University Of Southampton
Discovery of small molecule HIV-1 integrase dimerization inhibitors.
Bioorg Med Chem Lett 22: 3109-14 (2012)
University Of Siena
An approach for differentiating isozymes. Construction of libraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases.
Bioorg Med Chem Lett 22: 3147-51 (2012)
Seoul National University
Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes.
Eur J Med Chem 52: 70-81 (2012)
Sichuan University
Pentachlorophenol hydroxylase, a poorly functioning enzyme required for degradation of pentachlorophenol by Sphingobium chlorophenolicum.
Biochemistry 51: 3848-60 (2012)
University Of Colorado Boulder
Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinasea (PI3Ka) inhibitors.
Bioorg Med Chem 20: 2837-44 (2012)
Zhejiang University
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorg Med Chem 20: 3119-27 (2012)
Yb Chavan College Of Pharmacy
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Bioorg Med Chem 20: 2912-22 (2012)
University Of Hacettepe
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.
Eur J Med Chem 52: 205-12 (2012)
Chinese Academy Of Sciences
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.
Bioorg Med Chem Lett 22: 3343-8 (2012)
General Hospital Of Pla
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Bioorg Med Chem Lett 22: 3311-6 (2012)
Bristol-Myers Squibb
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potentß isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorg Med Chem Lett 22: 3198-202 (2012)
Glaxosmithkline
Bis-spirolabdane diterpenoids from Leonotis nepetaefolia.
J Nat Prod 75: 728-34 (2012)
University Of Mississippi
New structure-activity relationships of A- and D-ring modified steroidal aromatase inhibitors: design, synthesis, and biochemical evaluation.
J Med Chem 55: 3992-4002 (2012)
University Of Coimbra
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques.
Bioorg Med Chem Lett 22: 3181-7 (2012)
China Pharmaceutical University
Studies on gambogic acid (IV): Exploring structure-activity relationship with I¿B kinase-beta (IKKß).
Eur J Med Chem 51: 110-23 (2012)
China Pharmaceutical University
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Bioorg Med Chem 20: 3038-48 (2012)
Sun Yat-Sen University
Isoquinoline derivatives as potent CRTH2 receptor antagonists: synthesis and SAR.
Bioorg Med Chem Lett 22: 3305-10 (2012)
Taisho Pharmaceutical
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
Bioorg Med Chem Lett 22: 3349-53 (2012)
Mrc Technology
Discovery and optimization of a novel spiropyrrolidine inhibitor ofß-secretase (BACE1) through fragment-based drug design.
J Med Chem 55: 9069-88 (2012)
Pfizer
Development of a novel class of glucose transporter inhibitors.
J Med Chem 55: 3827-36 (2012)
The Ohio State University
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).
J Med Chem 55: 4806-23 (2012)
Siena Biotech
Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications.
J Med Chem 55: 5676-703 (2012)
Universit£
Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor.
J Enzyme Inhib Med Chem 28: 661-70 (2013)
Federal University Of Sao Paulo
Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz.
J Enzyme Inhib Med Chem 28: 685-9 (2013)
Jeju National University
(3,4-Dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and its derivatives as carbonic anhydrase isoenzymes inhibitors.
J Enzyme Inhib Med Chem 28: 402-6 (2013)
Atatürk University
Design and synthesis of potent, orally efficacious hydroxyethylamine derivedß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J Med Chem 55: 9025-44 (2012)
Amgen
Design and preparation of a potent series of hydroxyethylamine containingß-secretase inhibitors that demonstrate robust reduction of centralß-amyloid.
J Med Chem 55: 9009-24 (2012)
Amgen
4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators.
Bioorg Med Chem Lett 22: 3235-9 (2012)
Lundbeck Research Usa
Steroidal C-21 heteroaryl thioethers. Part 3: pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids).
Bioorg Med Chem Lett 22: 3291-5 (2012)
Merck Research Laboratories
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett 22: 3208-12 (2012)
Abbott Laboratories
A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study.
Eur J Med Chem 52: 111-22 (2012)
Dalian University Of Technology
Discovery of novel tricyclic compounds as squalene synthase inhibitors.
Bioorg Med Chem 20: 3072-93 (2012)
Daiichi Sankyo
Semisynthetic neoclerodanes as kappa opioid receptor probes.
Bioorg Med Chem 20: 3100-10 (2012)
The University Of Kansas
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies.
Bioorg Med Chem Lett 22: 3256-60 (2012)
Birla Institute Of Technology
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase.
Bioorg Med Chem Lett 22: 3296-300 (2012)
Sanofi Us
Conformationally restricted novel pyrazole derivatives: synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitors.
Bioorg Med Chem Lett 22: 3248-55 (2012)
Civentichem (India)
Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.
Bioorg Med Chem Lett 22: 3332-5 (2012)
Chinese Academy Of Sciences
Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.
Bioorg Med Chem Lett 22: 3244-7 (2012)
University Of Virginia
Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors.
Bioorg Med Chem Lett 22: 3284-6 (2012)
Beijing Institute Of Biotechnology
Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists.
Bioorg Med Chem Lett 22: 3354-7 (2012)
Merck Research Laboratories
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
Nature 485: 62-68 (2012)
The Scripps Research Institute
Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.
Bioorg Med Chem Lett 22: 3327-31 (2012)
Cylene Pharmaceuticals
Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists.
Bioorg Med Chem Lett 22: 3366-9 (2012)
Glaxosmithkline
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.
Bioorg Med Chem Lett 22: 2775-9 (2012)
Kitasato University
The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin.
Bioorg Med Chem Lett 22: 2698-700 (2012)
Technical University Of Lodz
Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators.
Bioorg Med Chem 20: 2982-91 (2012)
Chinese Academy Of Sciences
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton.
Bioorg Med Chem 20: 2992-9 (2012)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Synthesis and biological activity of potent HIV-1 protease inhibitors based on Phe-Pro dihydroxyethylene isosteres.
J Med Chem 55: 3900-10 (2012)
University Of Trieste
Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.
J Med Chem 55: 3837-51 (2012)
Amgen
Discovery of PG545: a highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis.
J Med Chem 55: 3804-13 (2012)
Progen Pharmaceuticals
Synthesis and evaluation of analogues of estrone-3-O-sulfamate as potent steroid sulfatase inhibitors.
Bioorg Med Chem 20: 2506-19 (2012)
University Of Bath
Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52.
J Med Chem 55: 4114-22 (2012)
Max Planck Institute Of Psychiatry
Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52.
J Med Chem 55: 4123-31 (2012)
Max Planck Institute Of Psychiatry
Computational design and discovery of"minimally structured" hERG blockers.
J Med Chem 55: 4010-4 (2012)
University Of Bologna
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.
J Med Chem 55: 3101-12 (2012)
National Center For Advancing Translational Sciences
Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerases.
J Med Chem 55: 3814-26 (2012)
University Of Michigan
Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.
J Med Chem 55: 3852-66 (2012)
Sichuan University
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
J Med Chem 55: 3261-73 (2012)
University Of Vienna
Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists.
Bioorg Med Chem Lett 22: 2807-10 (2012)
Cephalon
A new pancreatic lipase inhibitor from Broussonetia kanzinoki.
Bioorg Med Chem Lett 22: 2760-3 (2012)
Chungbuk National University
Design and synthesis of potent, isoxazole-containing renin inhibitors.
Bioorg Med Chem Lett 22: 2670-4 (2012)
Merck Frosst Centre For Therapeutic Research
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors.
Bioorg Med Chem Lett 22: 2837-42 (2012)
Korea Research Institute Of Chemical Technology
Pyrazolopyrimidines as dual Akt/p70S6K inhibitors.
Bioorg Med Chem Lett 22: 2693-7 (2012)
Exelixis
Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).
J Med Chem 55: 3792-803 (2012)
Johann Wolfgang Goethe University
Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.
J Med Chem 55: 3193-200 (2012)
Bmssi Umr 5086 Cnrs/Universit£
Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.
J Med Chem 55: 4664-82 (2012)
University Of Michigan
Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors.
J Med Chem 55: 3135-43 (2012)
Chinese Academy Of Sciences
Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver.
Drug Metab Dispos 40: 1080-4 (2012)
Kanazawa University
Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.
Bioorg Med Chem 20: 2595-602 (2012)
Graduate School Of Gyeongsang National University
Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor.
Bioorg Med Chem Lett 22: 2738-43 (2012)
Pfizer
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.
Bioorg Med Chem Lett 22: 2689-92 (2012)
Kitasato University
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.
Bioorg Med Chem 20: 2527-34 (2012)
Sun Yat-Sen University
Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.
Bioorg Med Chem 20: 2603-13 (2012)
Northern Kentucky University
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Bioorg Med Chem Lett 22: 2818-22 (2012)
Merck Research Laboratories
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.
Bioorg Med Chem Lett 22: 2827-32 (2012)
Chinese Academy Of Sciences
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Bioorg Med Chem Lett 22: 2811-7 (2012)
Merck Research Laboratories
Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis-radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib.
Bioorg Med Chem Lett 22: 2850-5 (2012)
Helmholtz-Zentrum Dresden-Rossendorf
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent.
Bioorg Med Chem Lett 22: 2803-6 (2012)
Shionogi
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies.
Eur J Med Chem 52: 1-13 (2012)
Universidad De Navarra
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.
J Med Chem 55: 3891-9 (2012)
Universit£
In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease.
J Med Chem 55: 4231-43 (2012)
Universidad De Granada
Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A.
Medchemcomm 2: 1217-1222 (2011)
University Of Kansas
Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases.
Eur J Med Chem 51: 259-70 (2012)
Vilnius University
Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.
Bioorg Med Chem Lett 22: 2748-52 (2012)
Chinese Academy Of Sciences
Design and synthesis of pyrrolo[3,2-d]pyrimidine human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors: exploration of novel back-pocket binders.
J Med Chem 55: 3975-91 (2012)
Takeda Pharmaceutical
Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors.
J Med Chem 55: 3878-90 (2012)
Harvard Medical School
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.
J Med Chem 55: 3777-91 (2012)
Taipei Medical University
Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
J Med Chem 55: 3578-82 (2012)
Imperial College
Selective inhibition of biotin protein ligase from Staphylococcus aureus.
J Biol Chem 287: 17823-32 (2012)
University Of Adelaide
Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation.
Bioorg Med Chem Lett 22: 2730-3 (2012)
Glaxosmithkline
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Bioorg Med Chem Lett 22: 2968-72 (2012)
Glaxosmithkline
CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: reduction of CNS side effects by introducing polar functional groups.
Bioorg Med Chem Lett 22: 2894-7 (2012)
Shionogi
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Bioorg Med Chem Lett 22: 2880-4 (2012)
S*Bio
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step.
Eur J Med Chem 51: 216-26 (2012)
Universit£
Synthesis and evaluation of [¹8F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).
Bioorg Med Chem 20: 3065-71 (2012)
Karolinska Institutet
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
J Med Chem 55: 3644-66 (2012)
Arena Pharmaceuticals
Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead.
J Med Chem 55: 3066-75 (2012)
Nankai University
Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.
J Med Chem 55: 4205-19 (2012)
St. Jude Children'S Research Hospital
Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.
J Med Chem 55: 3521-34 (2012)
Monash University
Pyrazolo[4,3-c][1,2]benzothiazines 5,5-dioxide: a promising new class of Staphylococcus aureus NorA efflux pump inhibitors.
J Med Chem 55: 3568-72 (2012)
Universit£
Calcitonin gene-related peptide (CGRP) receptor antagonists: novel aspartates and succinates.
Bioorg Med Chem Lett 22: 2912-6 (2012)
Bristol-Myers Squibb Research & Development
Calcitonin gene-related peptide (CGRP) receptor antagonists: pyridine as a replacement for a core amide group.
Bioorg Med Chem Lett 22: 2917-21 (2012)
Bristol-Myers Squibb Research & Development
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active¿-secretase modulators.
Bioorg Med Chem Lett 22: 2906-11 (2012)
Pfizer
Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.
Bioorg Med Chem Lett 22: 2794-7 (2012)
Glaxosmithkline
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism.
Bioorg Med Chem Lett 22: 2856-60 (2012)
Pfizer
Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.
J Med Chem 55: 3756-76 (2012)
Takeda Pharmaceutical
Prospective acetylcholinesterase inhibitory activity of indole and its analogs.
Bioorg Med Chem Lett 22: 2885-8 (2012)
Naresuan University
Pyrazine-based Syk kinase inhibitors.
Bioorg Med Chem Lett 22: 2784-8 (2012)
RhôNe-Poulenc Rorer
Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors.
Bioorg Med Chem 20: 2721-38 (2012)
Emory University
Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction.
Eur J Med Chem 51: 286-93 (2012)
Universit£
Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett 22: 2866-71 (2012)
Bristol-Myers Squibb
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.
Bioorg Med Chem Lett 22: 2843-9 (2012)
Advinus Therapeutics
Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists.
Bioorg Med Chem Lett 22: 2954-8 (2012)
National Kaohsiung Normal University
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
Bioorg Med Chem Lett 22: 2943-7 (2012)
Pfizer
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.
Eur J Med Chem 51: 184-92 (2012)
Vu University Amsterdam
Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma.
J Nat Prod 75: 784-8 (2012)
Korea University
Molecular cloning, characterization, and inhibition studies of aß-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
J Med Chem 55: 3513-20 (2012)
Union Life Sciences
Tyrosine modified analogues of thea4ß7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: synthesis and biological evaluation.
Bioorg Med Chem 20: 2638-44 (2012)
University Of Auckland
Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain.
Bioorg Med Chem Lett 22: 2932-7 (2012)
Merck Research Laboratories
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent.
Bioorg Med Chem Lett 22: 2898-901 (2012)
Shionogi
The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Bioorg Med Chem Lett 22: 2922-6 (2012)
Janssen Pharmaceutica
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active ?-secretase inhibitor.
J Med Chem 55: 3414-24 (2012)
Pfizer
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.
J Med Chem 55: 3488-501 (2012)
Neuraxon
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.
J Med Chem 55: 3588-92 (2012)
Huazhong University Of Science And Technology
Design of ?-amyloid aggregation inhibitors from a predicted structural motif.
J Med Chem 55: 3002-10 (2012)
Stanford University
Development of clickable active site-directed photoaffinity probes for ?-secretase.
Bioorg Med Chem Lett 22: 2997-3000 (2012)
Memorial Sloan-Kettering Cancer Center
Design and synthesis of novel lactate dehydrogenase a inhibitors by fragment-based lead generation.
J Med Chem 55: 3285-306 (2012)
Astrazeneca
Synthesis and structure elucidation of novel fused 1,2,4-triazine derivatives as potent inhibitors targeting CYP1A1 activity.
Bioorg Med Chem 20: 2624-37 (2012)
King Abdulaziz University
Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: the benzothiophene ring as an effective moiety.
Bioorg Med Chem Lett 22: 2948-50 (2012)
Universit£
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
J Med Chem 55: 4101-13 (2012)
Genentech
A new strategy for detection and development of tractable telomerase inhibitors.
J Med Chem 55: 3678-86 (2012)
University Of California
Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases.
Bioorg Med Chem 20: 2739-46 (2012)
Hokkaido University
Consequences of linker length alteration of thea7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333.
Bioorg Med Chem Lett 22: 2380-4 (2012)
The University Of Sydney
Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.
J Med Chem 55: 4527-38 (2012)
Eli Lilly
Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor.
J Med Chem 55: 3036-48 (2012)
Bristol-Myers Squibb
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
J Med Chem 55: 4896-933 (2012)
Pfizer
The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.
Medchemcomm 2: 1016-1020 (2011)
Nih Chemical Genomics Center
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.
ACS Med Chem Lett 3: 232-237 (2012)
TBA
Structure aided design of chimeric antibiotics.
Bioorg Med Chem Lett 22: 2428-33 (2012)
University Of Queensland
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy.
Bioorg Med Chem Lett 22: 2411-4 (2012)
Takeda California
Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening.
Bioorg Med Chem Lett 22: 2388-92 (2012)
Zhejiang Gongshang University
Discovery of a new binding mode for a series of liver X receptor agonists.
Bioorg Med Chem Lett 22: 2407-10 (2012)
Amgen
Synthesis and biological evaluation of benzoisothiazole derivatives possessing N,N-dimethylformimidamide group as 5-HT6 receptor antagonists.
Bioorg Med Chem 20: 2707-12 (2012)
Ewha Womans University
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1.
Bioorg Med Chem Lett 22: 2497-502 (2012)
Sanofi-Aventis R&D
Discovery of nor-seco himbacine analogs as thrombin receptor antagonists.
Bioorg Med Chem Lett 22: 2544-9 (2012)
Pfizer
Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.
Eur J Med Chem 51: 277-85 (2012)
University Of Strasburg
Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents.
Eur J Med Chem 51: 294-9 (2012)
Anhui Medical University
Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.
Eur J Med Chem 51: 92-8 (2012)
Daiichi Sankyo
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Eur J Med Chem 51: 60-6 (2012)
Shandong University
Recent advances in the synthesis of raloxifene: a selective estrogen receptor modulator.
Eur J Med Chem 51: 17-34 (2012)
Torrey Pines Institute For Molecular Studies
Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors.
Chem Biol Drug Des 80: 89-98 (2012)
Korea Research Institute Of Chemical Technology
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.
J Med Chem 55: 5143-50 (2012)
Keio University
Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity.
J Med Chem 55: 3228-41 (2012)
The Institute Of Cancer Research
Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.
J Med Chem 55: 2960-9 (2012)
Taiho Pharmaceutical
Discovery of oxazole-based PDE4 inhibitors with picomolar potency.
Bioorg Med Chem Lett 22: 2594-7 (2012)
Merck Research Laboratories
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
Bioorg Med Chem Lett 22: 2536-43 (2012)
Pfizer
Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.
J Med Chem 55: 3387-97 (2012)
Georgia State University
Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists.
J Med Chem 55: 3687-98 (2012)
Gwangju Institute Of Science And Technology (Gist)
Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.
Bioorg Med Chem 20: 2762-72 (2012)
Tubitak Mam Chemistry Institute P K 21 Gebze
Synthesis of a-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase.
J Enzyme Inhib Med Chem 28: 576-82 (2013)
Institute For Advanced Studies In Basic Sciences (Iasbs)
The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.
J Med Chem 55: 3027-35 (2012)
Universit£
Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies.
J Med Chem 55: 4539-50 (2012)
Hoffmann-La Roche
Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists.
Bioorg Med Chem 20: 2338-52 (2012)
Takeda Pharmaceutical
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett 22: 2444-9 (2012)
Merck Research Laboratories
Tyrosyl-DNA phosphodiesterase 1 inhibitor from an anamorphic fungus.
J Nat Prod 75: 764-7 (2012)
Biomedicinal Information Research Center (Birc)
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
J Med Chem 55: 3479-87 (2012)
University Of Cape Town
Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.
J Med Chem 55: 3201-15 (2012)
Mcgill University
In silico scaffold evaluation and solid phase approach to identify new gelatinase inhibitors.
Bioorg Med Chem 20: 2323-37 (2012)
Colosseum Combinatorial Chemistry Centre For Technology (C4T Scarl)
Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2).
Bioorg Med Chem 20: 2221-6 (2012)
University Of Alberta
Synthesis and P2Y2 receptor agonist activities of uridine 5'-phosphonate analogues.
Bioorg Med Chem 20: 2304-15 (2012)
Ghent University
Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.
Bioorg Med Chem 20: 2208-13 (2012)
Balikesir University
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Bioorg Med Chem 20: 2235-51 (2012)
Minase Research Institute
C-C bond formation at C-2 of a quinoline ring: synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors.
Bioorg Med Chem 20: 2199-207 (2012)
University Of Hyderabad Campus
3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.
Bioorg Med Chem Lett 22: 2514-7 (2012)
Eli Lilly
Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.
Bioorg Med Chem 20: 2427-34 (2012)
Purdue University
From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.
Bioorg Med Chem Lett 22: 2963-7 (2012)
Glaxosmithkline
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.
Bioorg Med Chem Lett 22: 2550-4 (2012)
Serenex
Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNFa-induced nuclear factor-¿B activation inhibition.
Eur J Med Chem 50: 393-404 (2012)
Sun Yat-Sen University
Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.
Eur J Med Chem 50: 304-10 (2012)
Clermont Universit£
Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening.
Bioorg Med Chem Lett 22: 2450-5 (2012)
Sanofi Pharmaceuticals
Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor.
Bioorg Med Chem Lett 22: 2456-9 (2012)
Glaxosmithkline
N-Caffeoyl serotonin as selective COX-2 inhibitor.
Bioorg Med Chem Lett 22: 2494-6 (2012)
Kinki University
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.
Bioorg Med Chem Lett 22: 2434-9 (2012)
Sk Biopharmaceuticals
Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.
J Med Chem 55: 3274-84 (2012)
Instituto De Qu£Mica M£Dica (Csic)
Synthesis and evaluation of a set of para-substituted 4-phenylpiperidines and 4-phenylpiperazines as monoamine oxidase (MAO) inhibitors.
J Med Chem 55: 3242-9 (2012)
Neurosearch Sweden
Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides.
J Med Chem 55: 3353-63 (2012)
University Of Kansas
Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with ??-adrenoceptor affinities.
Bioorg Med Chem 20: 2290-303 (2012)
Jagiellonian University Medical College
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.
Eur J Med Chem 50: 332-43 (2012)
University Of Messina
Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4'-piperidine]-2-ones as potential c-Met inhibitors.
Eur J Med Chem 50: 370-5 (2012)
Southern Medical University
In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Drug Metab Dispos 40: 1093-103 (2012)
Bristol-Myers Squibb
The discovery of novel β-secretase inhibitors: pharmacophore modeling, virtual screening, and docking studies.
Chem Biol Drug Des 79: 972-80 (2012)
Peking University Health Science Center
Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists.
Bioorg Med Chem Lett 22: 2560-4 (2012)
Monash University (Parkville Campus)
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Bioorg Med Chem Lett 22: 2527-33 (2012)
Chungnam National University
Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors.
J Enzyme Inhib Med Chem 28: 545-51 (2013)
Shandong University
Synthesis and HIV-1 RT inhibitory action of novel (4/6-substituted benzo[d]thiazol -2-yl)thiazolidin-4-ones. Divergence from the non-competitive inhibition mechanism.
J Enzyme Inhib Med Chem 28: 113-22 (2013)
Aristotle University Of Thessaloniki
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.
J Enzyme Inhib Med Chem 28: 583-92 (2013)
Sun Yat-Sen University
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.
J Enzyme Inhib Med Chem 28: 294-8 (2013)
Ataturk University
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity.
J Enzyme Inhib Med Chem 28: 565-8 (2013)
Yeungnam University
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.
J Med Chem 55: 3250-60 (2012)
Ambit Biosciences
Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
J Med Chem 55: 3011-20 (2012)
Drexel University College Of Medicine
Lead optimization of 17ß-HSD1 inhibitors of the (hydroxyphenyl)naphthol sulfonamide type for the treatment of endometriosis.
J Med Chem 55: 3307-18 (2012)
Saarland University
Discovery of cyclic sulfone hydroxyethylamines as potent and selectiveß-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloidß-peptides.
J Med Chem 55: 3364-86 (2012)
Novartis Pharma
Novel cGMP efflux inhibitors identified by virtual ligand screening (VLS) and confirmed by experimental studies.
J Med Chem 55: 3049-57 (2012)
University Of Troms£
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
J Med Chem 55: 2597-605 (2012)
Peking University
Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
Bioorg Med Chem 20: 2282-9 (2012)
Westf£Lische Wilhelms-Universit£T M£Nster
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.
Bioorg Med Chem 20: 2266-73 (2012)
Universit£
Proteasome inhibitors for cancer therapy.
Bioorg Med Chem 20: 2362-8 (2012)
Cephalon
2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.
Bioorg Med Chem 20: 2353-61 (2012)
University Of Melbourne
An example of designed multiple ligands spanning protein classes: dual MCH-1R antagonists/DPPIV inhibitors.
Bioorg Med Chem Lett 22: 2464-9 (2012)
Prosidion
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists.
Bioorg Med Chem Lett 22: 2572-8 (2012)
Pfizer
The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett 22: 2585-9 (2012)
Merck Research Laboratories
Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors.
J Med Chem 55: 2724-36 (2012)
Uppsala University
Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
Bioorg Med Chem Lett 22: 2609-12 (2012)
Merck Research Laboratories
Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug.
Eur J Med Chem 50: 179-95 (2012)
Pfizer
Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.
J Med Chem 55: 2846-57 (2012)
Hanmi Research Center
Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity.
J Med Chem 55: 2820-34 (2012)
Research Triangle Institute
Fluorophosphonylated nucleoside derivatives as new series of thymidine phosphorylase multisubstrate inhibitors.
J Med Chem 55: 2758-68 (2012)
Universit£
Favourable involvement ofa2A-adrenoreceptor antagonism in the I2-imidazoline binding sites-mediated morphine analgesia enhancement.
Bioorg Med Chem 20: 2259-65 (2012)
University Of Camerino
N¿?¿-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Bioorg Med Chem 20: 2444-54 (2012)
Duquesne University
Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.
Bioorg Med Chem 20: 2392-404 (2012)
Griffith University
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Bioorg Med Chem 20: 2435-43 (2012)
Northwestern University
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Bioorg Med Chem Lett 22: 2510-3 (2012)
Neuraxon
Discovery of P2X3 selective antagonists for the treatment of chronic pain.
Bioorg Med Chem Lett 22: 2565-71 (2012)
Astrazeneca
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management.
Bioorg Med Chem Lett 22: 2604-8 (2012)
Abbott Laboratories
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J Med Chem 55: 2803-10 (2012)
University Of Washington
From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists.
J Med Chem 55: 2574-84 (2012)
Laboratoires Fournier
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARß/d-selective ligand with inverse agonistic properties.
J Med Chem 55: 2858-68 (2012)
Philipps University
Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.
ACS Med Chem Lett 3: 146-150 (2012)
TBA
Blind prediction of host-guest binding affinities: a new SAMPL3 challenge.
J Comput Aided Mol Des 26: 475-87 (2012)
University Of California San Diego
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Bioorg Med Chem Lett 22: 2620-3 (2012)
Glaxosmithkline
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.
Bioorg Med Chem Lett 22: 2534-5 (2012)
Kangwon National University
2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator.
Bioorg Med Chem Lett 22: 2635-9 (2012)
University Of Louisville
Discovery of GS-9451: an acid inhibitor of the hepatitis C virus NS3/4A protease.
Bioorg Med Chem Lett 22: 2629-34 (2012)
Gilead Sciences
Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists.
Bioorg Med Chem 20: 2369-75 (2012)
Astellas Pharma
Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.
Bioorg Med Chem Lett 22: 2613-9 (2012)
Merck Research Laboratories
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.
Bioorg Med Chem Lett 22: 2182-5 (2012)
Universit£
Pyrrolovesamicols--synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers.
Bioorg Med Chem Lett 22: 2163-6 (2012)
Institute Of Radiopharmacy
Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1).
Bioorg Med Chem Lett 22: 2287-90 (2012)
Bristol-Myers Squibb
Molecular modeling study of cyclic pentapeptide CXCR4 antagonists: new insight into CXCR4-FC131 interactions.
Bioorg Med Chem Lett 22: 2146-50 (2012)
Pharmadesign
Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett 22: 2262-5 (2012)
Amgen
Synthesis and evaluation of a new series of 1'-cyclobutyl-6-(4-piperidyloxy)spiro[benzopyran-2,4'-piperidine] derivatives as high affinity and selective histamine-3 receptor (H3R) antagonists.
Bioorg Med Chem Lett 22: 2151-3 (2012)
Cephalon
Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.
Eur J Med Chem 50: 264-73 (2012)
St. John'S University
Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold.
Eur J Med Chem 50: 255-63 (2012)
University Of Ljubljana
Synthesis and antidiabetic performance of ?-amino ketone containing nabumetone moiety.
Bioorg Med Chem 20: 2119-30 (2012)
Southwest University
Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.
Bioorg Med Chem Lett 22: 2308-11 (2012)
Purdue University
Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.
Bioorg Med Chem 20: 2180-8 (2012)
University Of Virginia
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
J Med Chem 55: 2945-59 (2012)
Merck Research Laboratories
Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
J Med Chem 55: 2388-405 (2012)
Janssen-Cilag
Design, synthesis and biological evaluation of novel (E)-?-benzylsulfonyl chalcone derivatives as potential BRAF inhibitors.
Eur J Med Chem 50: 288-95 (2012)
Nanjing University
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.
Eur J Med Chem 50: 216-29 (2012)
Universit£
Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors.
Bioorg Med Chem 20: 2010-8 (2012)
Nanjing University
Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists.
Bioorg Med Chem Lett 22: 2167-71 (2012)
Lundbeck Research Usa
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett 22: 2154-9 (2012)
University Of Alberta
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorg Med Chem Lett 22: 2230-4 (2012)
Glaxosmithkline
Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.
J Nat Prod 75: 599-604 (2012)
Chinese Academy Of Sciences
Symplocin A, a linear peptide from the Bahamian cyanobacterium Symploca sp. Configurational analysis of N,N-dimethylamino acids by chiral-phase HPLC of naphthacyl esters.
J Nat Prod 75: 425-31 (2012)
University Of California
Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.
J Med Chem 55: 2737-45 (2012)
University Of British Columbia
SAR and biological evaluation of 3-azabicyclo[3.1.0]hexane derivatives asµ opioid ligands.
Bioorg Med Chem Lett 22: 2200-3 (2012)
Pfizer
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
J Biol Chem 287: 11788-97 (2012)
University Of North Carolina
Inhibition of galactosyltransferases by a novel class of donor analogues.
J Med Chem 55: 2015-24 (2012)
University Of East Anglia
Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.
J Med Chem 55: 2811-9 (2012)
Institut De Chimie Des Substances Naturelles (Icsn)
Structure-activity relationship study of a CXC chemokine receptor type 4 antagonist, FC131, using a series of alkene dipeptide isosteres.
J Med Chem 55: 2746-57 (2012)
Kyoto University
Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.
J Med Chem 55: 2688-701 (2012)
Janssen-Cilag
Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).
Drug Metab Dispos 40: 1041-50 (2012)
Novartis Institutes For Biomedical Research
Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity.
Bioorg Med Chem Lett 22: 2279-82 (2012)
Agricultural Research Service
Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
Bioorg Med Chem Lett 22: 2204-8 (2012)
Cisi
Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity.
Bioorg Med Chem Lett 22: 2271-8 (2012)
Prosidion
Structure-based virtual screening approach to the discovery of p38 MAP kinase inhibitors.
Bioorg Med Chem Lett 22: 2195-9 (2012)
Sejong University
Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes.
Bioorg Med Chem Lett 22: 2347-9 (2012)
Korea University
Design and synthesis of novel sulfonamide-containing bradykinin hB(2) receptor antagonists. Synthesis and structure-relationships ofa,a-tetrahydropyranylglycine.
Bioorg Med Chem 20: 2091-100 (2012)
Menarini Ricerche
Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus.
Bioorg Med Chem 20: 2152-7 (2012)
Chulalongkorn University
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Bioorg Med Chem Lett 22: 2330-7 (2012)
Astrazeneca R&D Boston
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Bioorg Med Chem Lett 22: 2242-6 (2012)
Panthera Biopharma
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.
Bioorg Med Chem Lett 22: 2266-70 (2012)
Galapagos
Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors.
Bioorg Med Chem Lett 22: 2283-6 (2012)
Exelixis
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Bioorg Med Chem Lett 22: 2257-61 (2012)
School Of Chemistry & Chemical Engineering Of Guangxi Normal University
Wake-promoting agents: search for next generation modafinil: part II.
Bioorg Med Chem Lett 22: 2315-7 (2012)
Cephalon
Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.
Bioorg Med Chem Lett 22: 2235-8 (2012)
University Of Alberta
Synthesis and inhibitory activity of ureidophosphonates, against acetylcholinesterase: pharmacological assay and molecular modeling.
Bioorg Chem 22-7 (2012)
Institute For Advanced Studies In Basic Sciences (Iasbs)
Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selectiveµ-antagonist activity.
Eur J Med Chem 50: 44-54 (2012)
National Institute On Drug Abuse And The National Institute On Alcohol Abuse And Alcoholism
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptorsa/¿ dual agonists.
Bioorg Med Chem 20: 2141-51 (2012)
Universit£
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents.
Bioorg Med Chem 20: 2067-81 (2012)
Rti International
Might the observeda(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?
Bioorg Med Chem 20: 2082-90 (2012)
Universit£
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.
Bioorg Med Chem 20: 2172-9 (2012)
Central Drug Research Institute
Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor.
ACS Comb Sci 14: 197-204 (2012)
Bristol-Myers Squibb Research And Development
Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.
Chem Biol Drug Des 79: 1007-17 (2012)
Washington University
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arth
J Med Chem 55: 2623-40 (2012)
S Bio
Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds.
J Med Chem 55: 2899-903 (2012)
Kyoto University
Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors.
J Med Chem 55: 2970-80 (2012)
Taiho Pharmaceutical
Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine7¿°¿ methionine7¿° mutant.
J Med Chem 55: 2711-23 (2012)
Chinese Academy Of Sciences
Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2'-deoxyuridine, 5-iodo-3'-fluoro-2',3'-dideoxyuridine, and 3'-fluorothymidine for molecular radiotherapy of cancer: synthesis and biological evaluation.
J Med Chem 55: 2649-71 (2012)
University Of Nebraska Medical Center
Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J Med Chem 55: 2641-8 (2012)
Genzyme
1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence.
Eur J Med Chem 50: 129-39 (2012)
Universidad De Granada
Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity.
Bioorg Med Chem 20: 1644-58 (2012)
Kyorin Pharmaceutical
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Bioorg Med Chem 20: 1947-51 (2012)
Tianjin Key Laboratory On Technologies Enabling Development Of Clinical Therapeutics And Diagnostics
Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.
Bioorg Med Chem 20: 1671-8 (2012)
Florida A&M University
Characterization of TAE684 as a potent LRRK2 kinase inhibitor.
Bioorg Med Chem Lett 22: 1864-9 (2012)
University Of Dundee
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.
Bioorg Med Chem Lett 22: 2015-9 (2012)
Harvard Medical School
New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series.
Bioorg Med Chem Lett 22: 1860-3 (2012)
Novartis Institutes For Biomedical Research
Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selectivea-melanocyte-stimulating hormone (a-MSH) analogues.
J Med Chem 55: 1969-77 (2012)
Novo Nordisk
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
J Med Chem 55: 2882-93 (2012)
Neuraxon
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.
J Med Chem 55: 2869-81 (2012)
Genentech
Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.
Drug Metab Dispos 40: 982-9 (2012)
Khon Kaen University
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.
Bioorg Med Chem Lett 22: 1903-7 (2012)
Janssen Pharmaceutica
Depigmenting activity of new kojic acid derivative obtained as a side product in the synthesis of cinnamate of kojic acid.
Bioorg Med Chem Lett 22: 2004-7 (2012)
Hanyang University
Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes.
J Nat Prod 75: 271-4 (2012)
Korea Research Institute Of Bioscience And Biotechnology
Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors.
J Med Chem 55: 2125-43 (2012)
University Of Strasburg
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.
J Med Chem 55: 2112-24 (2012)
University Of Milan-Bicocca
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.
J Med Chem 55: 1593-611 (2012)
Amgen
Discovery of a Potent HIV Integrase Inhibitor that Leads to a Prodrug with Significant anti-HIV Activity.
ACS Med Chem Lett 2: 877-881 (2011)
TBA
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Drug Metab Dispos 40: 943-51 (2012)
Pfizer
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Bioorg Med Chem Lett 22: 1886-90 (2012)
London School Of Hygiene And Tropical Medicine
Aminopyrimidinone cdc7 kinase inhibitors.
Bioorg Med Chem Lett 22: 1940-3 (2012)
Abbott Laboratories
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.
Bioorg Med Chem Lett 22: 2070-4 (2012)
Biogen Idec
Synthesis and structure-activity relationship (SAR) study of 4-azabenzoxazole analogues as H3 antagonists.
Bioorg Med Chem Lett 22: 2075-8 (2012)
Merck Research Laboratories
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
Bioorg Med Chem Lett 22: 1969-75 (2012)
Zafes/Liff/Osf Goethe-University Frankfurt
Structure-activity relationship of the 7-hydroxy benzimidazole analogs as glycogen synthase kinase 3ß inhibitor.
Bioorg Med Chem Lett 22: 1891-4 (2012)
Crystalgenomics
Novel TIPP (H-Tyr-Tic-Phe-Phe-OH) analogues displaying a wide range of efficacies at thed opioid receptor. Discovery of two highly potent and selectived opioid agonists.
Bioorg Med Chem Lett 22: 1899-902 (2012)
Clinical Research Institute Of Montreal
Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia.
Bioorg Med Chem Lett 22: 1870-3 (2012)
Arena Pharmaceuticals
3,4-Diarylpiperidines as potent renin inhibitors.
Bioorg Med Chem Lett 22: 1953-7 (2012)
Merck Frosst Center For Therapeutic Research
Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-ß type I receptor kinase.
Bioorg Med Chem Lett 22: 2024-9 (2012)
Taisho Pharmaceutical
Imidazo[1,2-a]pyrazines as novel PI3K inhibitors.
Bioorg Med Chem Lett 22: 1874-8 (2012)
Spanish National Cancer Research Centre (Cnio)
Aminoimidazoles as BACE-1 inhibitors: the challenge to achieve in vivo brain efficacy.
Bioorg Med Chem Lett 22: 1854-9 (2012)
Astrazeneca
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.
Bioorg Med Chem 20: 1690-8 (2012)
University Of Ferrara
N-(4-Substituted-benzoyl)-N'-(ß-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorg Med Chem 20: 1801-16 (2012)
University Of Debrecen
Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.
J Med Chem 55: 2301-10 (2012)
Institut Pasteur Korea
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
Bioorg Med Chem Lett 22: 2099-101 (2012)
University Of Toronto
Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.
Bioorg Med Chem Lett 22: 1926-30 (2012)
Kansai University
Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.
Bioorg Med Chem Lett 22: 1944-8 (2012)
Astrazeneca
Effect of alkyl chain length on sphingosine kinase 2 selectivity.
Bioorg Med Chem Lett 22: 6817-20 (2012)
Virginia Tech
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
J Med Chem 55: 1999-2014 (2012)
The Hong Kong Polytechnic University
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
J Med Chem 55: 2416-26 (2012)
University Of Washington
Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.
J Med Chem 55: 1858-67 (2012)
Amgen
Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.
J Med Chem 55: 1868-97 (2012)
Amgen
Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.
Eur J Med Chem 49: 354-64 (2012)
Shanxi University
Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo.
Bioorg Med Chem Lett 22: 1958-62 (2012)
Massachusetts General Hospital
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Bioorg Med Chem Lett 22: 1980-4 (2012)
Neuraxon
Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists.
Bioorg Med Chem Lett 22: 2052-62 (2012)
Amgen
Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety--fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis.
Bioorg Med Chem 20: 1699-710 (2012)
University Of Warsaw
Development of live-cell imaging probes for monitoring histone modifications.
Bioorg Med Chem 20: 1887-92 (2012)
Japan Science And Technology Agency
AlCl3 induced (hetero)arylation of 2,3-dichloroquinoxaline: a one-pot synthesis of mono/disubstituted quinoxalines as potential antitubercular agents.
Bioorg Med Chem 20: 1711-22 (2012)
University Of Hyderabad Campus
Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain.
J Med Chem 55: 2342-52 (2012)
National Institute Of Radiological Sciences
Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.
Drug Metab Dispos 40: 919-27 (2012)
Genentech
2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives as potent and selective histamine-3 receptor antagonists.
J Med Chem 55: 2452-68 (2012)
Pfizer
Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.
J Med Chem 55: 2406-15 (2012)
National Institute Of Mental Health
Methoxychalcone inhibitors of androgen receptor translocation and function.
Bioorg Med Chem Lett 22: 2105-9 (2012)
National Cancer Institute-Bethesda
Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.
Bioorg Med Chem Lett 22: 1985-8 (2012)
Brandeis University
5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors.
Bioorg Med Chem Lett 22: 1989-94 (2012)
Glaxosmithkline
Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives.
Eur J Med Chem 49: 343-53 (2012)
North-West University
Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists.
Eur J Med Chem 49: 183-90 (2012)
Beijing Institute Of Technology
Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents.
Eur J Med Chem 49: 271-8 (2012)
East China University Of Science And Technology
Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors.
Eur J Med Chem 49: 200-10 (2012)
National Medicines Institute
STAT-3 inhibitory bisabolanes from Carthamus glaucus.
J Nat Prod 75: 453-8 (2012)
Universit£
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
J Med Chem 55: 2353-66 (2012)
Takeda Pharmaceutical
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
J Med Chem 55: 2561-73 (2012)
Korea Institute Of Science And Technology
Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation.
J Med Chem 55: 2102-11 (2012)
Istituto Di Biostrutture E Bioimmagini
Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors.
Bioorg Med Chem Lett 22: 1976-9 (2012)
Chinese Academy Of Sciences
The discovery of aminopyrazines as novel, potent Na(v)1.7 antagonists: hit-to-lead identification and SAR.
Bioorg Med Chem Lett 22: 2033-42 (2012)
Amgen
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors.
Eur J Med Chem 49: 24-40 (2012)
Dongguk University-Seoul
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKe kinases.
Bioorg Med Chem Lett 22: 2063-9 (2012)
Astrazeneca R&D Boston
Discovery of a new class of ghrelin receptor antagonists.
Bioorg Med Chem Lett 22: 2046-51 (2012)
Amgen
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
Eur J Med Chem 49: 379-96 (2012)
Universit£
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.
Bioorg Med Chem 20: 1779-93 (2012)
University Of St. Andrews
Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.
Bioorg Med Chem 20: 1760-6 (2012)
Instituto Oswaldo Cruz
Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.
J Nat Prod 75: 257-61 (2012)
Paris-Sud University
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
Eur J Med Chem 49: 310-23 (2012)
University Of Lille
Design and synthesis of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as novel tyrosinase inhibitors.
Eur J Med Chem 49: 245-52 (2012)
Pusan National University
QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).
Bioorg Med Chem 20: 1388-95 (2012)
University Of Tours
Synthesis, molecular docking and biological evaluation of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents.
Bioorg Med Chem 20: 1373-9 (2012)
Nanjing University
Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases.
Bioorg Med Chem 20: 1740-8 (2012)
Korea Research Institute Of Bioscience And Biotechnology
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.
Bioorg Med Chem Lett 22: 2094-8 (2012)
University Of Siena
Adamantyl N-benzylbenzamide: new series of depigmentation agents with tyrosinase inhibitory activity.
Bioorg Med Chem Lett 22: 2110-3 (2012)
Amorepacific Corporation R&D Center
Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.
Bioorg Med Chem Lett 22: 2125-9 (2012)
Loma Linda University School Of Medicine
Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist.
Bioorg Med Chem Lett 22: 2020-3 (2012)
Shionogi
Inhibition of the ß-class carbonic anhydrases from Mycobacterium tuberculosis with carboxylic acids.
J Enzyme Inhib Med Chem 28: 392-6 (2013)
Universit?? Degli Studi Di Firenze
Inhibitory effect of novel pyrazole carboxamide derivatives on human carbonic anhydrase enzyme.
J Enzyme Inhib Med Chem 28: 328-36 (2013)
Dumlupinar University
Analysis of saponins and phenolic compounds as inhibitors of a-carbonic anhydrase isoenzymes.
J Enzyme Inhib Med Chem 28: 412-7 (2013)
Ege University
Tripeptides with non-code amino acids as potential serine proteases inhibitors.
J Enzyme Inhib Med Chem 28: 639-43 (2013)
Medical University Of Bialystok
Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1.
J Enzyme Inhib Med Chem 28: 456-62 (2013)
South Dakota State University
Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions.
J Enzyme Inhib Med Chem 28: 388-91 (2013)
Universit?? Degli Studi Di Firenze
Three new aromatic sulfonamide inhibitors of carbonic anhydrases I, II, IV and XII.
J Enzyme Inhib Med Chem 28: 289-93 (2013)
Universit?? Di Firenze
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.
J Enzyme Inhib Med Chem 28: 397-401 (2013)
Ecole Nationale Superieure De Chimie De Montpellier
Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine.
J Enzyme Inhib Med Chem 28: 463-7 (2013)
University Roma Tre
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.
Bioorg Med Chem Lett 22: 1510-9 (2012)
Astrazeneca R&D Boston
Dualß2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD.
Bioorg Med Chem Lett 22: 1523-6 (2012)
Sun Yat-Sen University
Novel morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.
Bioorg Med Chem Lett 22: 1546-9 (2012)
Cephalon
New active HIV-1 protease inhibitors derived from 3-hexanol: conformation study of the free inhibitors in crystalline state and in complex with the enzyme.
Chem Biol Drug Des 79: 798-809 (2012)
Technical University Of LÓDz
Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro.
BMC Biochem 13: 3 (2012)
Academy Of Sciences Of The Czech Republic
Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett 22: 1727-30 (2012)
Merck Research Laboratories
Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol and their glucosidase inhibitory activity.
Bioorg Med Chem Lett 22: 1538-40 (2012)
Chulalongkorn University
Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.
Bioorg Med Chem Lett 22: 1494-8 (2012)
Amri
4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activity.
Bioorg Med Chem Lett 22: 1504-9 (2012)
Cephalon
Identification of binding specificity-determining features in protein families.
J Med Chem 55: 1926-39 (2012)
Sandia National Laboratories
3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of humana4ß2 neuronal nicotinic acetylcholine receptors.
Bioorg Med Chem Lett 22: 1797-813 (2012)
The Ohio State University
QSAR studies for prediction of cross-ß sheet aggregate binding affinity and selectivity.
Bioorg Med Chem 20: 1434-41 (2012)
The Ohio State University College Of Medicine
Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA).
Bioorg Med Chem 20: 1557-68 (2012)
University Of Antwerp
Cloning, characterization and sulfonamide inhibition studies of ana-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
Bioorg Med Chem 20: 1403-10 (2012)
Slovak Academy Of Sciences
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors.
Bioorg Med Chem 20: 1475-81 (2012)
Michigan State University
First enantioselective syntheses of the dopamine D1 and D2 receptor modulators, (+)- and (-)-govadine.
Bioorg Med Chem Lett 22: 1557-9 (2012)
University Of British Columbia
¿-Carbolines: a novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration.
Bioorg Med Chem Lett 22: 1619-24 (2012)
Astrazeneca R&D Montreal
Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.
Chem Biol 19: 155-63 (2012)
Boston College
Discovery of potent and selective covalent inhibitors of JNK.
Chem Biol 19: 140-54 (2012)
Harvard Medical School
Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile.
J Med Chem 55: 2242-50 (2012)
Peking University
Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.
J Med Chem 55: 2324-41 (2012)
Wuhan University
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.
ACS Med Chem Lett 3: 39-42 (2012)
TBA
Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I.
Bioorg Med Chem Lett 22: 1579-81 (2012)
The University Of Sydney
SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.
Bioorg Med Chem Lett 22: 1633-8 (2012)
Abbott Laboratories
Fluorinated ?F508-CFTR correctors and potentiators for PET imaging.
Bioorg Med Chem Lett 22: 1602-5 (2012)
University Of California Davis
Novel inhibitors of nitric oxide synthase with antioxidant properties.
Eur J Med Chem 49: 118-26 (2012)
Universit£
Recent advances in antitubercular natural products.
Eur J Med Chem 49: 1-23 (2012)
Universidad Aut£Noma De Nuevo Le£N
Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.
J Med Chem 55: 2251-64 (2012)
Universit£
"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer.
J Med Chem 55: 1635-44 (2012)
Trinity College
Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.
J Med Chem 55: 1731-50 (2012)
Imperial College
Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.
Bioorg Med Chem 20: 1545-56 (2012)
Jagiellonian University Medical College
Design, synthesis and biological evaluation of N-phenylsulfonylnicotinamide derivatives as novel antitumor inhibitors.
Bioorg Med Chem 20: 1411-6 (2012)
Nanjing University
Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors.
Bioorg Med Chem Lett 22: 1560-4 (2012)
Istituto Di Biostrutture E Bioimmagini-Cnr
Optimization of hydroxybenzothiazoles as novel potent and selective inhibitors of 17ß-HSD1.
J Med Chem 55: 2469-73 (2012)
Saarland University
Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.
J Med Chem 55: 1771-82 (2012)
University Of Nottingham
A new strategy for the development of highly potent and selective plasmin inhibitors.
J Med Chem 55: 1171-80 (2012)
Philipps University Marburg
Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.
J Nat Prod 75: 262-6 (2012)
University Of Montana
Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.
J Nat Prod 75: 285-9 (2012)
Biomedicinal Information Research Center (Birc)
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.
J Med Chem 55: 1721-30 (2012)
Universit£
Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.
J Med Chem 55: 2474-8 (2012)
H. Lee Moffitt Cancer Center And Research Institute
Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.
Bioorg Med Chem 20: 1442-60 (2012)
Chugai Pharmaceutical
Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes: class II fructose-1,6-bis-phosphate aldolases, type I phosphomannose isomerase, and phosphoglucose isomerase.
Bioorg Med Chem 20: 1511-20 (2012)
Univ Paris-Sud
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity.
J Med Chem 55: 1559-71 (2012)
Universit£
New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.
J Med Chem 55: 1572-82 (2012)
University Of Li£Ge
CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.
ACS Med Chem Lett 2: 818-823 (2011)
TBA
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.
Bioorg Med Chem Lett 22: 1591-7 (2012)
Spanish National Cancer Research Centre (Cnio)
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.
Bioorg Med Chem Lett 22: 1655-9 (2012)
Astrazeneca
New inhibitor of 3-phosphoinositide dependent protein kinase-1 identified from virtual screening.
Bioorg Med Chem Lett 22: 1629-32 (2012)
Central China Normal University
Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.
Bioorg Med Chem Lett 22: 1575-8 (2012)
Merck Research Laboratories
17ß-Arylsulfonamides of 17ß-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase.
Bioorg Med Chem 20: 1535-44 (2012)
University Of Waterloo
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett 22: 1550-6 (2012)
Merck Research Laboratories
Aß-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity.
Bioorg Med Chem Lett 22: 1606-10 (2012)
Sanofi Pharmaceuticals
Imidazopyridines as selective CYP3A4 inhibitors.
Bioorg Med Chem Lett 22: 1611-4 (2012)
The Scripps Research Institute
Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
Bioorg Med Chem Lett 22: 1788-92 (2012)
Daiichi Sankyo
Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists.
Bioorg Med Chem Lett 22: 1649-54 (2012)
Kyung Hee University
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.
Bioorg Med Chem Lett 22: 1750-5 (2012)
Arena Pharmaceuticals
Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors.
Bioorg Med Chem Lett 22: 1678-81 (2012)
Novartis Institutes For Biomedical Research
Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists.
Bioorg Med Chem Lett 22: 1686-9 (2012)
Amgen
Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.
Bioorg Med Chem Lett 22: 1690-4 (2012)
Astrazeneca R&D Boston
Wake-promoting agents: search for next generation modafinil: part I.
Bioorg Med Chem Lett 22: 2312-4 (2012)
Cephalon
Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs.
Bioorg Med Chem Lett 22: 1701-4 (2012)
University Of Mississippi
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
J Nat Prod 75: 135-41 (2012)
Science University Of Tokyo
Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities.
J Nat Prod 75: 267-70 (2012)
Korean Institute Of Oriental Medicine (Kiom)
N-phosphonocarbonylpyrrolidine derivatives of guanine: a new class of bi-substrate inhibitors of human purine nucleoside phosphorylase.
J Med Chem 55: 1612-21 (2012)
Academy Of Sciences Of The Czech Republic
Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
J Med Chem 55: 2173-84 (2012)
University Of Oxford
Rapid development of piperidine carboxamides as potent and selective anaplastic lymphoma kinase inhibitors.
J Med Chem 55: 1698-705 (2012)
Amgen
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
J Med Chem 55: 2287-300 (2012)
Vanderbilt Institute Of Chemical Biology
Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
J Med Chem 55: 1751-7 (2012)
Abbott Laboratories
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
J Med Chem 55: 2311-23 (2012)
University Of Pennsylvania
Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.
Bioorg Med Chem 20: 1251-8 (2012)
King'S College London
Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3ß (GSK-3ß) inhibitors for type 2 diabetics.
Bioorg Med Chem 20: 1188-200 (2012)
Kyorin Pharmaceutical
Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.
Bioorg Med Chem 20: 1201-12 (2012)
Daiichi Sankyo
Synthesis and antihormonal properties of novel 11ß-benzoxazole-substituted steroids.
Bioorg Med Chem Lett 22: 1705-8 (2012)
Research Triangle Institute
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
J Med Chem 55: 1127-36 (2012)
Novartis Institutes For Biomedical Research
Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.
J Med Chem 55: 1465-77 (2012)
Georgia Institute Of Technology
Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.
J Med Chem 55: 4027-61 (2012)
Universit£
Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors.
Bioorg Med Chem Lett 22: 1739-42 (2012)
Wenzhou Medical College
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.
Bioorg Med Chem Lett 22: 1674-7 (2012)
Sapienza University Of Rome
Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.
Bioorg Med Chem Lett 22: 1779-83 (2012)
Amgen
A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.
Bioorg Med Chem 20: 1175-80 (2012)
Punjabi University
Discovery and development of spleen tyrosine kinase (SYK) inhibitors.
J Med Chem 55: 3614-43 (2012)
Rigel
Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J Med Chem 55: 1662-70 (2012)
Pfizer
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists.
J Med Chem 55: 1490-9 (2012)
Universit£
5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.
J Med Chem 55: 1645-61 (2012)
Instituto De Qu£Mica M£Dica-Csic
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.
J Med Chem 55: 1671-81 (2012)
The University Of Melbourne
Identification of novel adenosine A(2A) receptor antagonists by virtual screening.
J Med Chem 55: 1904-9 (2012)
Heptares Therapeutics
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.
Bioorg Med Chem 20: 1222-30 (2012)
Academy Of Sciences Of The Czech Republic
Synthesis and evaluation of potent and selective human V1a receptor antagonists as potential ligands for PET or SPECT imaging.
Bioorg Med Chem 20: 1337-45 (2012)
Lehigh University
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
Bioorg Med Chem Lett 22: 1774-8 (2012)
Merck Research Laboratories
Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion.
J Med Chem 55: 2154-62 (2012)
Trinity College
A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.
ACS Chem Biol 7: 698-706 (2012)
Moffitt Cancer Center
Contribution of phosphates and adenine to the potency of adenophostins at the IP3 receptor: synthesis of all possible bisphosphates of adenophostin A.
J Med Chem 55: 1706-20 (2012)
University Of Bath
Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.
J Med Chem 55: 1511-25 (2012)
The Beatson Institute For Cancer Research
Diverse heterocyclic scaffolds as allosteric inhibitors of AKT.
J Med Chem 55: 1261-73 (2012)
Astrazeneca
Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.
ACS Med Chem Lett 2: 907-912 (2011)
TBA
Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.
Bioorg Med Chem 20: 1291-7 (2012)
Florida A&M University
New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
Eur J Med Chem 49: 102-9 (2012)
Universit£
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.
Eur J Med Chem 49: 68-73 (2012)
Ondokuz Mayis University
[¹¿?¿F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
Bioorg Med Chem Lett 22: 1308-13 (2012)
Ge Healthcare
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Bioorg Med Chem Lett 22: 1433-8 (2012)
Celgene
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.
Bioorg Med Chem 20: 1319-36 (2012)
University Of Auckland
Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain.
Bioorg Med Chem Lett 22: 1340-3 (2012)
Stanford University School Of Medicine
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.
Bioorg Med Chem Lett 22: 1448-54 (2012)
Vu University Amsterdam
Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation.
J Med Chem 55: 1622-34 (2012)
Monash University (Parkville Campus)
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.
J Med Chem 55: 1303-17 (2012)
Instituto De Qu£Mica M£Dica
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier.
J Med Chem 55: 1758-70 (2012)
Duquesne University
1,4-dioxane, a suitable scaffold for the development of novel M3 muscarinic receptor antagonists.
J Med Chem 55: 1783-7 (2012)
Universit£
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.
J Med Chem 55: 852-70 (2012)
Scripps Florida
Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.
J Med Chem 55: 1538-52 (2012)
Takeda Pharmaceutical
Ligand-based design of a potent and selective inhibitor of cytochrome P450 2C19.
J Med Chem 55: 1205-14 (2012)
Amgen
Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease.
J Med Chem 55: 1402-17 (2012)
Janssen Research And Development
Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.
J Med Chem 55: 1106-16 (2012)
University Of Kansas
Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency.
J Med Chem 55: 783-96 (2012)
Glaxosmithkline
Rational approaches to improving selectivity in drug design.
J Med Chem 55: 1424-44 (2012)
University Of Cambridge
Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides.
Bioorg Med Chem Lett 22: 1371-4 (2012)
Tottori University
Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.
Eur J Med Chem 48: 321-9 (2012)
Gifu Pharmaceutical University
Exploring activity cliffs in medicinal chemistry.
J Med Chem 55: 2932-42 (2012)
Rheinische Friedrich-Wilhelms-Universit£T
Synthesis and evaluation of ¹?F-labeled styryltriazole and resveratrol derivatives for ?-amyloid plaque imaging.
J Med Chem 55: 883-92 (2012)
Sungkyunkwan University School Of Medicine
New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis.
J Enzyme Inhib Med Chem 28: 163-71 (2013)
Centre De Recherche De Gif
Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol.
J Enzyme Inhib Med Chem 28: 137-42 (2013)
Baylor University
Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.
J Enzyme Inhib Med Chem 27: 628-40 (2012)
Shandong University
Structural basis of selective inhibition of human tankyrases.
J Med Chem 55: 1360-7 (2012)
Abo Akademi University
Unbiased binding assays for discovering small-molecule probes and drugs.
Bioorg Med Chem 20: 1979-89 (2012)
Broad Institute Of Harvard And Mit
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.
Bioorg Med Chem Lett 22: 1352-7 (2012)
Artvin£Oruh University
Binding evaluation of fragment-based scaffolds for probing allosteric enzymes.
J Med Chem 55: 1287-95 (2012)
Universit£
Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
J Med Chem 55: 1189-204 (2012)
University Of Lille
Design, synthesis, and biological evaluation of new diaminoquinazolines as ?-catenin/Tcf4 pathway inhibitors.
J Med Chem 55: 1346-59 (2012)
State University Of New York
2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions.
Bioorg Med Chem 20: 1310-8 (2012)
Shenyang Pharmaceutical University
Chemical modulators working at pharmacological interface of target proteins.
Bioorg Med Chem 20: 1893-901 (2012)
Korea University College Of Pharmacy Sejong-Ro
Discovery of novel selective inhibitors for EGFR-T790M/L858R.
Bioorg Med Chem Lett 22: 1365-70 (2012)
Dalian University Of Technology
Pyrazoloquinolines as PDE10A inhibitors: discovery of a tool compound.
Bioorg Med Chem Lett 22: 1335-9 (2012)
Merck Research Laboratories
Anion inhibition studies of ana-carbonic anhydrase from the living fossil Astrosclera willeyana.
Bioorg Med Chem Lett 22: 1314-6 (2012)
Slovak Academy Of Sciences
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test.
Bioorg Med Chem Lett 22: 1421-6 (2012)
Cephalon
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.
Bioorg Med Chem Lett 22: 1427-32 (2012)
Celgene
Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802).
Bioorg Med Chem 20: 1271-80 (2012)
Chugai Pharmaceutical
Substituents at the naphthalene C3 position of (-)-Cercosporamide derivatives significantly affect the maximal efficacy as PPAR¿ partial agonists.
Bioorg Med Chem Lett 22: 1348-51 (2012)
Daiichi Sankyo
Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).
Bioorg Med Chem Lett 22: 1384-7 (2012)
Bristol-Myers Squibb
A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.
Bioorg Med Chem Lett 22: 1380-3 (2012)
Northeast Ohio Medical University
The green tea polyphenol (2)-epigallocatechin-3-gallate (EGCG) is not aß-secretase inhibitor.
Bioorg Med Chem Lett 22: 1408-14 (2012)
Beijing Institute Of Pharmacology And Toxicology
Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents.
Bioorg Med Chem Lett 22: 1317-21 (2012)
University Of Nottingham
Design and synthesis of boronic acid inhibitors of endothelial lipase.
Bioorg Med Chem Lett 22: 1397-401 (2012)
Tufts University School Of Medicine
Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide.
J Enzyme Inhib Med Chem 28: 172-82 (2013)
Umeå University
Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.
J Med Chem 55: 1181-8 (2012)
Institute Of Advanced Chemistry Of Catalonia (Iqac-Csic)
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
J Med Chem 55: 2915-31 (2012)
Oxagen
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
J Med Chem 55: 1021-46 (2012)
Evotec (Uk)
Structure-activity relationships for naturally occurring coumarins asß-secretase inhibitor.
Bioorg Med Chem 20: 784-8 (2012)
Kinki University
Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.
Eur J Med Chem 48: 214-30 (2012)
Universit£
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.
Eur J Med Chem 48: 284-95 (2012)
Universit£
Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists.
Bioorg Med Chem Lett 22: 797-800 (2012)
Janssen Pharmaceutica
Small molecule inhibitors of BRAF in clinical trials.
Bioorg Med Chem Lett 22: 789-92 (2012)
The Institute Of Cancer Research
The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.
Bioorg Med Chem Lett 22: 1019-22 (2012)
Merck Research Laboratories
Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.
Bioorg Med Chem Lett 22: 829-32 (2012)
Universit£
VX-322: a novel dual receptor tyrosine kinase inhibitor for the treatment of acute myelogenous leukemia.
J Med Chem 55: 725-34 (2012)
University Of Kentucky
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.
J Med Chem 55: 1898-903 (2012)
Heptares Therapeutics
STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.
Bioorg Med Chem 20: 750-8 (2012)
Massachusetts General Hospital
AMG 837: a potent, orally bioavailable GPR40 agonist.
Bioorg Med Chem Lett 22: 1267-70 (2012)
Amgen
Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability.
Bioorg Med Chem Lett 22: 824-8 (2012)
Prosidion
Enzymatic transformation of caffeic acid with enhanced cyclooxygenase-2 inhibitory activity.
Bioorg Med Chem Lett 22: 793-6 (2012)
Kyungpook National University
Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2).
Bioorg Med Chem Lett 22: 868-71 (2012)
Activx Biosciences
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
J Med Chem 55: 1147-60 (2012)
University Of Regensburg
Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein.
J Med Chem 55: 1242-51 (2012)
University Of California Davis
Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.
J Med Chem 55: 1368-81 (2012)
Exelixis
Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes.
J Enzyme Inhib Med Chem 28: 436-9 (2013)
Cairo University
Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three ß-class carbonic anhydrases from Mycobacterium tuberculosis.
J Enzyme Inhib Med Chem 28: 384-7 (2013)
Universit?? Degli Studi Di Firenze
Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.
ACS Chem Biol 7: 526-34 (2012)
University Of Tennessee Health Science Center
Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.
Bioorg Med Chem 20: 832-40 (2012)
Kinki University
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides.
Bioorg Med Chem 20: 714-33 (2012)
Takeda Pharmaceutical
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 3: an increase in aqueous solubility via the disruption of crystal packing.
Bioorg Med Chem Lett 22: 912-5 (2012)
Array Biopharma
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.
Bioorg Med Chem Lett 22: 901-6 (2012)
Vernalis (R&D)
SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist.
Bioorg Med Chem Lett 22: 854-8 (2012)
Merck Research Laboratory
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.
Eur J Med Chem 48: 206-13 (2012)
Sissa-Isas
Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1.
Eur J Med Chem 48: 153-63 (2012)
University Of M£Nster
Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.
Bioorg Med Chem Lett 22: 980-4 (2012)
Merck Frosst Centre For Therapeutic Research
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists.
Bioorg Med Chem Lett 22: 1055-60 (2012)
Amgen
Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.
Drug Metab Dispos 40: 671-9 (2012)
Kanazawa University
Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.
Bioorg Med Chem Lett 22: 850-3 (2012)
Central South University
Nonquaternary reactivators for organophosphate-inhibited cholinesterases.
J Med Chem 55: 465-74 (2012)
Human Biomolecular Research Institute
Design, synthesis, and biological evaluation of potent quinoline and pyrroloquinoline ammosamide analogues as inhibitors of quinone reductase 2.
J Med Chem 55: 367-77 (2012)
Purdue University
Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro.
Drug Metab Dispos 40: 655-61 (2012)
University Of Oslo
Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase.
Bioorg Med Chem Lett 22: 907-11 (2012)
University Of Canterbury
Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.
Bioorg Med Chem Lett 22: 1023-6 (2012)
Harvard Medical School
New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: synthesis and analysis of structure-activity relationships.
Bioorg Med Chem Lett 22: 1282-6 (2012)
University Of Karachi
Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid.
Bioorg Med Chem Lett 22: 1036-9 (2012)
China Pharmaceutical University
Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.
Eur J Med Chem 48: 97-107 (2012)
Quimique C£A.
Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases.
Eur J Med Chem 48: 143-52 (2012)
Institute Of The Sir Mortimer Jewish General Hospital
N¿?¿-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem 20: 910-4 (2012)
Duquesne University
Synthesis and evaluation of novel modified¿-lactam prostanoids as EP4 subtype-selective agonists.
Bioorg Med Chem 20: 702-13 (2012)
Minase Research Institute
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
Bioorg Med Chem 20: 1046-59 (2012)
Universit£
Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds.
J Med Chem 55: 1274-86 (2012)
University Of Lille
6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3ß: discovery of nitrile derivatives with picomolar potency.
Bioorg Med Chem Lett 22: 1005-8 (2012)
Activx Biosciences
Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase.
Bioorg Med Chem Lett 22: 942-4 (2012)
University Of The Punjab
An integrated computational workflow for efficient and quantitative modeling of renin inhibitors.
Bioorg Med Chem 20: 851-8 (2012)
Sanofi Us
Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.
Bioorg Med Chem 20: 949-61 (2012)
Kitasato University
Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor¿ selective agonists with protein-tyrosine phosphatase 1B inhibition.
Bioorg Med Chem 20: 1060-75 (2012)
Kyoto Pharmaceutical Industries
Steroidal C-21 heteroaryl thioethers (Part 2): discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids).
Bioorg Med Chem Lett 22: 1086-90 (2012)
Merck Research Laboratories
The discovery of potent antagonists of NPBWR1 (GPR7).
Bioorg Med Chem Lett 22: 1014-8 (2012)
Merck
Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines.
Bioorg Med Chem Lett 22: 929-32 (2012)
Novartis Institutes Of Biomedical Research
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors.
Bioorg Med Chem Lett 22: 1009-13 (2012)
S*Bio
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.
Bioorg Med Chem Lett 22: 1044-8 (2012)
Vanderbilt University Medical Center
Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency.
Bioorg Med Chem Lett 22: 1061-7 (2012)
Amgen
Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer.
Bioorg Med Chem Lett 22: 1230-6 (2012)
Pfizer
Multiparameter exploration of piperazine derivatives asd-opioid receptor agonists for CNS indications.
Bioorg Med Chem Lett 22: 1169-73 (2012)
Astrazeneca Pharmaceuticals
4-Piperidin-4-ylidenemethyl-benzamides asd-opioid receptor agonists for CNS indications: identifying clinical candidates.
Bioorg Med Chem Lett 22: 1174-8 (2012)
Astrazeneca Pharmaceuticals
Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H(3) receptor inverse agonists.
Bioorg Med Chem Lett 22: 1073-7 (2012)
Cephalon
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem 55: 1318-33 (2012)
Pfizer
Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH.
Bioorg Med Chem 20: 1100-12 (2012)
Max Planck Institute Of Molecular Physiology
Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF¿?) receptor antagonists.
Bioorg Med Chem 20: 1122-38 (2012)
Minase Research Institute
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.
Bioorg Med Chem Lett 22: 1165-8 (2012)
Array Biopharma
Structure-based de novo design and biochemical evaluation of novel BRAF kinase inhibitors.
Bioorg Med Chem Lett 22: 1027-30 (2012)
Sejong University
Identification of triazolopyridazinones as potent p38a inhibitors.
Bioorg Med Chem Lett 22: 1226-9 (2012)
Amgen
Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.
Bioorg Med Chem Lett 22: 1136-41 (2012)
Chugai Pharmaceutical
Structure-based library design and the discovery of a potent and selective mast cellß-tryptase inhibitor as an oral therapeutic agent.
Bioorg Med Chem Lett 22: 1049-54 (2012)
Sanofi Pharmaceuticals
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels.
J Med Chem 55: 1418-22 (2012)
Universit£
ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.
J Med Chem 55: 515-27 (2012)
Northwestern University
Novel 3-phenylpiperidine-4-carboxamides as highly potent and orally long-acting neurokinin-1 receptor antagonists with reduced CYP3A induction.
Bioorg Med Chem 20: 962-77 (2012)
Takeda Pharmaceutical
Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N¿?¿,5'-bis-ureido- and 5'-carbamoyl-N¿?¿-ureidoadenosine derivatives.
Bioorg Med Chem 20: 1008-19 (2012)
Brigham Young University
In vitro and in silico studies on substrate recognition and acceptance of human PKMYT1, a Cdk1 inhibitory kinase.
Bioorg Med Chem Lett 22: 1219-23 (2012)
Martin-Luther-University Halle-Wittenberg
Synthesis of novel histamine H4 receptor antagonists.
Bioorg Med Chem Lett 22: 1156-9 (2012)
Pfizer
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation.
Bioorg Med Chem Lett 22: 1125-9 (2012)
University Of Genoa
Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
Bioorg Med Chem Lett 22: 1111-7 (2012)
M.S. University Of Baroda
High-affinity fluorescent ligands for the 5-HT(3) receptor.
Bioorg Med Chem Lett 22: 1151-5 (2012)
University Of Bern
Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI.
J Enzyme Inhib Med Chem 27: 818-24 (2012)
Ataturk University
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site.
J Med Chem 55: 871-82 (2012)
Technische Universit£T M£Nchen
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
J Med Chem 55: 661-9 (2012)
Universitat De Barcelona
Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.
J Med Chem 55: 824-36 (2012)
Universidad Complutense De Madrid
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.
J Med Chem 55: 1056-71 (2012)
Tokyo University Of Pharmacy And Life Sciences
Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases.
J Med Chem 55: 961-5 (2012)
Islamic University Of Gaza
Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J Med Chem 55: 893-902 (2012)
The University Of Tokyo
Synthesis and biological evaluation of 4-[3-chloro-4-(3-fluorobenzyloxy)anilino]-6-(3-substituted-phenoxy)pyrimidines as dual EGFR/ErbB-2 kinase inhibitors.
Bioorg Med Chem 20: 877-85 (2012)
East China University Of Science And Technology
Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.
Bioorg Med Chem 20: 985-95 (2012)
University Of Applied Sciences
Cell-based and in-silico studies on the high intrinsic activity of two boron-containing salbutamol derivatives at the humanß2-adrenoceptor.
Bioorg Med Chem 20: 933-41 (2012)
Instituto Polit£Cnico Nacional (Ipn)
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A¿? adenosine receptor.
Bioorg Med Chem 20: 996-1007 (2012)
Universit£
Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
Bioorg Med Chem Lett 22: 1068-72 (2012)
Merck Research Laboratories
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
Bioorg Med Chem Lett 22: 1237-41 (2012)
Afraxis
Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.
Medchemcomm 2: 424-429 (2011)
Centre National De La Recherche Scientifique
Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist.
Medchemcomm 2: 325-330 (2011)
University Of Virginia
Discovery of novel and potent CRTH2 antagonists.
Bioorg Med Chem Lett 22: 1194-7 (2012)
Astellas Pharma
Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.
Bioorg Med Chem Lett 22: 1130-5 (2012)
Kobe Gakuin University
A multivalent approach to the discovery of long-actingß(2)-adrenoceptor agonists for the treatment of asthma and COPD.
Bioorg Med Chem Lett 22: 1213-8 (2012)
Theravance
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Bioorg Med Chem 20: 1076-89 (2012)
Academy Of Sciences Of The Czech Republic
In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor.
Bioorg Med Chem Lett 22: 1198-201 (2012)
Kyung Hee University
Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett 22: 1464-8 (2012)
Argenta Discovery
Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors.
Bioorg Med Chem 20: 34-41 (2011)
Astellas Pharma
Novel pyrazolo[1,5-a]pyridines as p110a-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR.
Bioorg Med Chem 20: 58-68 (2011)
University Of Auckland
Discovery of pyrazolo[1,5-a]pyridines as p110a-selective PI3 kinase inhibitors.
Bioorg Med Chem 20: 69-85 (2011)
University Of Auckland
Discovery of novela7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.
Bioorg Med Chem Lett 22: 1179-86 (2012)
Targacept
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J Med Chem 55: 914-23 (2012)
Pfizer
Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.
J Med Chem 55: 709-16 (2012)
Alantos Pharmaceuticals
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
J Med Chem 55: 943-55 (2012)
Neuraxon
Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway.
Bioorg Med Chem Lett 22: 76-81 (2011)
The Broad Institute Probe Development Center
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
Bioorg Med Chem Lett 22: 39-44 (2011)
Second Military Medical University
The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives.
Bioorg Med Chem Lett 22: 53-6 (2011)
Shenyang Pharmaceutical University
Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).
Bioorg Med Chem Lett 22: 71-5 (2011)
Arena Pharmaceuticals
Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents.
Bioorg Med Chem 20: 521-30 (2011)
Punjabi University
Novel bioactive metabolites of dipyrone (metamizol).
Bioorg Med Chem 20: 101-7 (2011)
Philipps-Universit£T
Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines.
Bioorg Med Chem 20: 108-16 (2011)
Medical University Of Gdansk
Design, synthesis, and anaplastic lymphoma kinase (ALK) inhibitory activity for a novel series of 2,4,8,22-tetraazatetracyclo[14.3.1.1³,¿?¿.1¿?¿,¹³]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene macrocycles.
J Med Chem 55: 449-64 (2012)
Cephalon
Chemistry and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.
J Med Chem 55: 717-24 (2012)
University Of Illinois At Chicago
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed.
J Biol Chem 287: 4248-59 (2012)
University Of Copenhagen
N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region.
Bioorg Med Chem 20: 215-24 (2011)
Seoul National University
Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.
Bioorg Med Chem 20: 125-36 (2011)
University Of Regensburg
Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties.
Bioorg Med Chem 20: 47-57 (2012)
National Cancer Institute
Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified oligoadenylates.
Bioorg Med Chem Lett 22: 181-5 (2011)
Academy Of Sciences Of The Czech Republic
Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.
Bioorg Med Chem Lett 22: 133-7 (2011)
Cephalon
Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase.
Bioorg Med Chem Lett 22: 110-4 (2011)
Shenyang Pharmaceutical University
Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs.
Bioorg Med Chem Lett 22: 45-8 (2012)
Cylene Pharmaceuticals
A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.
Bioorg Med Chem Lett 22: 65-70 (2011)
Merck Research Laboratories
Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications.
J Med Chem 55: 1789-808 (2012)
Merck Research Laboratories
Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
J Med Chem 55: 956-60 (2012)
Amgen
Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.
J Enzyme Inhib Med Chem 27: 886-91 (2012)
Laboratoire Synthese Et Reactivite Des Substances Naturelles
Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor.
J Med Chem 55: 735-42 (2012)
National Institute Of Diabetes And Digestive And Kidney Diseases
Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
J Med Chem 55: 1082-105 (2012)
Ambit Biosciences
Carbonic anhydrase inhibitors: in vitro inhibition of a isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.
J Enzyme Inhib Med Chem 28: 283-8 (2013)
Ondokuz Mayis University
2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis.
J Nat Prod 75: 82-7 (2012)
Fudan University
Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.
J Med Chem 55: 639-51 (2012)
University Of Illinois At Chicago
Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein.
J Med Chem 55: 966-70 (2012)
Cnrs/Universit£
Fragment based drug discovery: practical implementation based on¹¿F NMR spectroscopy.
J Med Chem 55: 678-87 (2012)
Amgen
Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38a.
Eur J Med Chem 48: 1-15 (2012)
Chemical Genomics Centre Of The Max Planck Society
Design and synthesis of novel ?-diketo derivatives as HIV-1 integrase inhibitors.
Bioorg Med Chem 20: 177-82 (2012)
Beijing University Of Technology
Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay.
Bioorg Med Chem Lett 22: 168-71 (2011)
The Second Military Medical University
Structure-based redesign of an edema toxin inhibitor.
Bioorg Med Chem 20: 368-76 (2012)
Utmb
Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1).
Bioorg Med Chem Lett 22: 90-5 (2011)
Xenon Pharmaceuticals
5-(2-amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors.
Bioorg Med Chem Lett 22: 96-101 (2011)
Nerviano Medical Sciences
5-HT2c receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs.
Bioorg Med Chem Lett 22: 347-52 (2011)
Korea Institute Of Science And Technology
Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2.
Bioorg Med Chem Lett 22: 271-7 (2011)
Astrazeneca
Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists.
Bioorg Med Chem Lett 22: 120-3 (2011)
Cephalon
Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.
Bioorg Med Chem Lett 22: 144-8 (2011)
Ono Pharmaceutical
Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics.
Bioorg Med Chem Lett 22: 461-7 (2011)
Griffin Discoveries
Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases.
Bioorg Med Chem Lett 22: 262-6 (2011)
Astrazeneca
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H¿?-antihistamines for insomnia.
Bioorg Med Chem Lett 22: 421-6 (2011)
Neurocrine Biosciences
Synthesis and evaluation of 4-alkoxy-[1'-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4'-piperidine)] analogues as histamine-3 receptor antagonists.
Bioorg Med Chem Lett 22: 186-9 (2011)
Cephalon
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
Bioorg Med Chem Lett 22: 138-43 (2011)
Pfizer
Novel poly(ADP-ribose) polymerase-1 inhibitors.
Bioorg Med Chem Lett 22: 222-4 (2011)
Cephalon
Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.
J Med Chem 55: 754-65 (2012)
Merck Research Laboratories
Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c
J Med Chem 55: 903-13 (2012)
Cephalon
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists.
J Med Chem 55: 797-811 (2012)
University Of Ferrara
Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.
J Med Chem 55: 106-14 (2012)
University Of Michigan
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J Med Chem 55: 140-52 (2012)
University Of Dundee
Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
J Med Chem 55: 1445-64 (2012)
Vanderbilt University Medical Center
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
J Med Chem 55: 1047-55 (2012)
University Of Toronto
Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
J Med Chem 55: 312-26 (2012)
University Of Auckland
Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities.
J Nat Prod 75: 111-4 (2012)
The University Of Tokyo
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
J Med Chem 55: 935-42 (2012)
Pfizer
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase
J Med Chem 55: 169-96 (2012)
S Bio
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
J Med Chem 55: 688-96 (2012)
University Of Alberta
Cyclopeptide Alkaloids from Ziziphus apetala.
J Nat Prod 74: 2571-5 (2011)
Kunming Institute Of Botany
Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.
J Nat Prod 74: 2489-96 (2011)
Kaohsiung Medical University
Identification of novela4ß2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
J Med Chem 55: 812-23 (2012)
University Of Illinois At Chicago
Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.
J Enzyme Inhib Med Chem 27: 880-5 (2012)
Agri Ibrahim Cecen University
Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules.
J Enzyme Inhib Med Chem 28: 316-9 (2013)
Kirklareli University
Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergica1- and serotonine 5-HT1A receptors.
J Med Chem 55: 23-36 (2012)
Universit£
Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.
Bioorg Med Chem 20: 283-95 (2011)
Purdue University
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3¿]-2,3-dihydro-1H-inden-1¿-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Bioorg Med Chem Lett 22: 508-11 (2011)
Universiti Sains Malaysia
Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Bioorg Med Chem Lett 22: 235-9 (2011)
Merck Research Laboratories
4,5-dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists.
Bioorg Med Chem Lett 22: 194-8 (2011)
Cephalon
SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
Bioorg Med Chem Lett 22: 199-203 (2011)
Merck Sharp & Dohme
Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons.
Bioorg Med Chem Lett 22: 313-8 (2011)
Ludwig-Maximilians-University Munich
Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A2A and A3 adenosine receptor ligands.
J Med Chem 55: 342-56 (2012)
Ewha Womans University
2-Amino-3-cyanopyridine derivatives as carbonic anhydrase inhibitors.
J Enzyme Inhib Med Chem 28: 305-10 (2013)
Gazi University
Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitors.
J Med Chem 55: 115-25 (2012)
Cephalon
Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling.
Eur J Med Chem 47: 239-54 (2012)
University Of The Mediterranean
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Bioorg Med Chem 20: 234-42 (2012)
University Of Oslo
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
Bioorg Med Chem 20: 1878-86 (2012)
University Of Oxford
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Bioorg Med Chem 20: 183-94 (2011)
Virginia Tech
4-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1).
Bioorg Med Chem Lett 22: 427-30 (2011)
Korea Research Institute Of Chemical Technology
Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.
Bioorg Med Chem Lett 22: 323-6 (2011)
Korea Research Institute Of Bioscience And Biotechnology
Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E2 synthase-1 inhibitors.
Bioorg Med Chem Lett 22: 285-8 (2011)
Dainippon Sumitomo Pharma
Hydroxycoumarins as selective MAO-B inhibitors.
Bioorg Med Chem Lett 22: 258-61 (2011)
Universit£
Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.
Bioorg Med Chem Lett 22: 231-4 (2011)
Institute Of Microbial Chemistry
Stereochemical diversity of AI-2 analogs modulates quorum sensing in Vibrio harveyi and Escherichia coli.
Bioorg Med Chem 20: 249-56 (2011)
Instituto De Tecnologia Qu£Mica E Biol£Gica
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase.
Eur J Med Chem 47: 493-500 (2012)
Vu University Amsterdam
5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.
Bioorg Med Chem Lett 22: 267-70 (2011)
Universit£
Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.
Bioorg Med Chem Lett 22: 747-52 (2011)
Celgene
Identification of oxazolidinediones and thiazolidinediones as potent 17ß-hydroxysteroid dehydrogenase type 3 inhibitors.
Bioorg Med Chem Lett 22: 504-7 (2011)
Sumitomo Chemical
Design, synthesis and in vitro evaluation of novel bivalent S-adenosylmethionine analogues.
Bioorg Med Chem Lett 22: 278-84 (2011)
University Of Leeds
Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for centrals1 receptors and comparison with fluoroalkyl homologs.
Bioorg Med Chem 20: 257-69 (2011)
Institute Of Radiopharmacy
Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides.
J Med Chem 55: 587-96 (2012)
Glaxosmithkline
7,8-dichloro-1-oxo-ß-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
J Med Chem 55: 403-13 (2012)
Ludwig-Maximilians University Of Munich
Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery.
J Med Chem 55: 576-86 (2012)
Glaxosmithkline
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
J Med Chem 55: 390-402 (2012)
Universidade Federal De Santa Catarina
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.
Bioorg Med Chem 20: 1940-6 (2012)
Indiana University
Discovery of cyclic amine-substituted benzoic acids as PPARa agonists.
Bioorg Med Chem Lett 22: 334-8 (2011)
Kyorin Pharmaceutical
New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.
Eur J Med Chem 47: 520-9 (2012)
Universit£
Quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors.
Bioorg Med Chem 20: 296-304 (2011)
Central China Normal University
Discovery of potent and specific CXCR3 antagonists.
Bioorg Med Chem Lett 22: 357-62 (2011)
Amgen
5-sulfonyl-benzimidazoles as selective CB2 agonists-part 2.
Bioorg Med Chem Lett 22: 547-52 (2011)
Janssen Pharmaceutica
Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors.
Bioorg Med Chem Lett 22: 339-42 (2011)
Chinese Academy Of Sciences
Discovery of pyrrolidine-basedß-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.
Bioorg Med Chem Lett 22: 240-4 (2011)
Merck Research Laboratories
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent¿-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
J Med Chem 55: 357-66 (2012)
Northwestern University
Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies.
J Med Chem 55: 558-62 (2012)
Boston University
Structure-activity analysis and cell-based optimization of human galactokinase inhibitors.
ACS Med Chem Lett 2: 667-672 (2011)
TBA
CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.
ACS Med Chem Lett 2: 620-625 (2011)
TBA
Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid.
Chembiochem 13: 85-96 (2012)
Gda£?Sk University Of Technology
Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
Bioorg Med Chem Lett 22: 363-6 (2011)
Amgen
Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptorß-selective ligands.
J Med Chem 55: 528-37 (2012)
University Of Illinois
Fused thiophene derivatives as MEK inhibitors.
Bioorg Med Chem Lett 22: 472-5 (2012)
Ucb Pharma
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism.
Bioorg Med Chem Lett 22: 367-70 (2011)
Amgen
One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities.
Bioorg Med Chem Lett 22: 410-4 (2011)
Birla Institute Of Technology
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.
Bioorg Med Chem Lett 22: 396-401 (2011)
Minase Research Institute
Novel and selective spiroindoline-based inhibitors of Sky kinase.
Bioorg Med Chem Lett 22: 190-3 (2011)
Pfizer
(±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban).
Bioorg Med Chem Lett 22: 523-6 (2011)
Duquesne University
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Bioorg Med Chem Lett 22: 415-20 (2011)
Pfizer
Structure-based design of PDK1 inhibitors.
Bioorg Med Chem Lett 22: 305-7 (2011)
S Bio
Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series.
Bioorg Med Chem Lett 22: 613-8 (2011)
Merck Research Laboratories
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists.
Bioorg Med Chem Lett 22: 537-42 (2011)
The Scripps Research Institute
Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.
Bioorg Med Chem Lett 22: 553-7 (2011)
Institute Of Pharmacology & Toxicology
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.
Eur J Med Chem 47: 111-24 (2012)
Alexander Technological Education Institute Of Thessaloniki
Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents.
Eur J Med Chem 47: 473-8 (2012)
Nanjing University
Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors.
Eur J Med Chem 47: 351-9 (2012)
University Of Hyderabad
A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography.
J Med Chem 55: 223-32 (2012)
University Hospital M£Nster
Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets.
Bioorg Med Chem 20: 510-20 (2011)
Purdue University
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
Eur J Med Chem 47: 97-103 (2012)
National Cheng Kung University
CK2a and CK2a' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.
Eur J Med Chem 47: 345-50 (2012)
The John Paul Ii Catholic University Of Lublin
3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-?-lactamase inhibitors.
Bioorg Med Chem Lett 22: 380-6 (2012)
The University Of Queensland
A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.
Bioorg Med Chem Lett 22: 729-32 (2011)
Hokkaido University
Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX.
Bioorg Med Chem Lett 22: 482-4 (2011)
North-West University
Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity.
Bioorg Med Chem 20: 311-6 (2011)
Jeju National University
Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity.
Bioorg Med Chem 20: 317-23 (2011)
Soochow University
Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.
Bioorg Med Chem 20: 346-55 (2011)
University Of Bonn
Elaborate ligand-based modeling and subsequent synthetic exploration unveil new nanomolar Ca2+/calmodulin-dependent protein kinase II inhibitory leads.
Bioorg Med Chem 20: 377-400 (2011)
University Of Jordan
Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen.
Bioorg Med Chem 20: 1354-63 (2012)
Macquarie University
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.
J Med Chem 55: 424-36 (2012)
Universit£
Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.
J Med Chem 54: 8328-42 (2011)
The Institute Of Cancer Research
Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.
J Med Chem 55: 327-41 (2012)
University Of Bristol
Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.
Chem Biol Drug Des 79: 157-65 (2012)
National Institutes Of Health
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.
J Med Chem 55: 437-48 (2012)
Bar-Ilan University
Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H3 receptor antagonists with potent cognition enhancing activity.
J Med Chem 55: 414-23 (2012)
Cephalon
Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic.
J Med Chem 54: 8305-20 (2011)
Tranzyme Pharma
Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals.
Drug Metab Dispos 40: 426-35 (2012)
University Of Washington
Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
Eur J Med Chem 47: 299-311 (2012)
Sun Yat-Sen University
Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.
Bioorg Med Chem 20: 356-67 (2011)
University Of Toyama
Potent adjuvantic activity of a CCR1-agonistic bis-quinoline.
Bioorg Med Chem Lett 22: 293-5 (2011)
University Of Kansas
Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assembly.
Bioorg Med Chem Lett 22: 591-6 (2011)
Carna Biosciences
Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins.
Bioorg Med Chem Lett 22: 558-60 (2011)
University Of Minnesota
Quinolinone-based agonists of S1P¿?: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.
Bioorg Med Chem Lett 22: 527-31 (2011)
Amgen
Lead diversification. Application to existing drug molecules: mifepristone 1 and antalarmin 8.
Bioorg Med Chem Lett 22: 723-8 (2011)
Pfizer
Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor.
J Med Chem 55: 538-52 (2012)
National Institute Of Diabetes And Digestive And Kidney Diseases
Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor.
J Med Chem 55: 250-67 (2012)
The National Center For Drug Screening
Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A.
ACS Med Chem Lett 2: 396-401 (2011)
U.S. Army Medical Research Institute For Infectious Diseases
LDV peptidomimetics equipped with biotinylated spacer-arms: synthesis and biological evaluation on CCRF-CEM cell line.
Bioorg Med Chem Lett 22: 586-90 (2011)
Universit£
Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.
Bioorg Med Chem Lett 22: 623-7 (2011)
Merck Frosst Centre For Therapeutic Research
Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases.
Bioorg Med Chem Lett 22: 456-60 (2011)
Shionogi
Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P¿? agonists with in vivo lymphocyte-depleting activity.
Bioorg Med Chem Lett 22: 628-33 (2011)
Amgen
Indole RSK inhibitors. Part 1: discovery and initial SAR.
Bioorg Med Chem Lett 22: 733-7 (2011)
Boehringer Ingelheim Pharmaceuticals
Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors.
Bioorg Med Chem 20: 446-54 (2011)
Saitama University
The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics.
Bioorg Med Chem 20: 498-509 (2011)
Pfizer
Bivalent molecular probes for dopamine D2-like receptors.
Bioorg Med Chem 20: 455-66 (2011)
Friedrich-Alexander University
Monoamine oxidase inhibition by C4-substituted phthalonitriles.
Bioorg Chem 40: 114-24 (2012)
North-West University
Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans.
Eur J Med Chem 47: 270-7 (2012)
University Of Eastern Finland
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.
Eur J Med Chem 47: 175-85 (2012)
Instituto De Qu£Mica M£Dica (Csic)
6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.
Eur J Med Chem 47: 337-44 (2012)
University Of Groningen
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors.
J Med Chem 55: 68-83 (2012)
University Of Lille
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious¿-secretase modulators in vivo.
J Med Chem 55: 489-502 (2012)
Schering-Plough Research Institute
Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases.
Bioorg Med Chem 19: 7318-37 (2011)
University Of Heidelberg
Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.
Bioorg Med Chem 20: 422-34 (2011)
Takeda Pharmaceutical
Lead optimisation of pyrazoles as novel FPR1 antagonists.
Bioorg Med Chem Lett 22: 532-6 (2011)
Astrazeneca
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.
J Med Chem 54: 8555-62 (2011)
Faculdade De Ci�Ncias E Tecnologia-Unl
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
Eur J Med Chem 47: 143-52 (2012)
Universit£
Chromenones as potent bradykinin B1 antagonists.
Bioorg Med Chem Lett 22: 619-22 (2011)
Amgen
Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent.
Bioorg Med Chem 19: 7365-73 (2011)
Institute Of Chemical Biology
Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.
J Med Chem 54: 8440-50 (2011)
Amgen
Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins.
BMC Biochem 12: 59 (2011)
Ghent University
Comparative study of the affinity and metabolism of type I and type II binding quinoline carboxamide analogues by cytochrome P450 3A4.
J Med Chem 55: 280-90 (2012)
Washington State University
Inhibition of glutathione S-transferase M1 by new gabosine analogues is essential for overcoming cisplatin resistance in lung cancer cells.
J Med Chem 54: 8574-81 (2011)
Academia Sinica
Mechanistic analysis of muraymycin analogues: a guide to the design of MraY inhibitors.
J Med Chem 54: 8421-39 (2011)
Hokkaido University
Synthesis of (glycopyranosyl-triazolyl)-purines and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B).
Chem Biodivers 8: 2035-44 (2011)
East China University Of Science And Technology
Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.
Bioorg Med Chem 19: 7338-48 (2011)
Microbiotix
Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase.
Bioorg Med Chem Lett 22: 610-2 (2011)
University Of Karachi
Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.
Bioorg Med Chem Lett 22: 679-82 (2011)
Johannes Gutenberg University
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
J Med Chem 55: 37-54 (2012)
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot
The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorg Med Chem Lett 22: 658-65 (2011)
Merck Research Laboratories
Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).
Bioorg Med Chem Lett 22: 718-22 (2011)
Mcmaster University
From libraries to candidate: the discovery of new ultra long-acting dibasicß2-adrenoceptor agonists.
Bioorg Med Chem Lett 22: 689-95 (2011)
Astrazeneca
Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett 22: 601-5 (2011)
Columbia University
Discovery of selective glucocorticoid receptor modulator MK-5932.
Bioorg Med Chem 19: 7374-86 (2011)
Merck Research Laboratories
Conformationally restricted analog and biotin-labeled probe based on beauveriolide III.
Bioorg Med Chem Lett 22: 696-9 (2011)
Tohoku University
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes.
Bioorg Med Chem 19: 7698-710 (2011)
Instituto Tecnol£Gico E Nuclear
Disulfide and amide-bridged cyclic peptide analogues of the VEGF8¿?¿9¿? fragment: synthesis, conformational analysis and biological evaluation.
Bioorg Med Chem 19: 7526-33 (2011)
Instituto De Qu£Mica M£Dica
Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines.
Bioorg Med Chem 19: 7482-92 (2011)
West Virginia University
2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.
Bioorg Med Chem Lett 21: 7367-72 (2011)
Novartis Institutes For Biomedical Research
Biaryl analogues of teriflunomide as potent DHODH inhibitors.
Bioorg Med Chem Lett 21: 7268-72 (2011)
RhôNe-Poulenc Rorer
Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.
Bioorg Med Chem Lett 21: 7287-90 (2011)
Merck Research Laboratories
Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
J Med Chem 54: 8353-61 (2011)
Universit£
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.
J Med Chem 54: 8271-7 (2011)
Ecole Nationale Sup£Rieure De Chimie De Montpellier
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities ass¿? receptor ligands.
Bioorg Med Chem 19: 7612-22 (2011)
Universit£
New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds.
Bioorg Med Chem 19: 7453-63 (2011)
The University Of Adelaide
Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
J Med Chem 54: 8616-31 (2011)
Takeda Pharmaceutical
Synthesis, structure-activity relationships, and mechanism of action of anti-HIV-1 lamellarin ? 20-sulfate analogues.
Bioorg Med Chem 19: 7541-50 (2011)
Nagasaki University
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.
Bioorg Med Chem 19: 7416-24 (2011)
Federal University Of Rio De Janeiro
Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents.
Bioorg Med Chem 19: 7635-42 (2011)
University Of Lisbon
Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction.
Bioorg Med Chem 19: 7690-7 (2011)
Tokyo University Of Science
Rational design and synthesis of aminopiperazinones asß-secretase (BACE) inhibitors.
Bioorg Med Chem Lett 21: 7255-60 (2011)
Research Informatics & Integrative Genomics
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.
Bioorg Med Chem Lett 21: 7399-404 (2011)
Merck Frosst Centre For Therapeutic Research
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.
Bioorg Med Chem Lett 21: 7344-50 (2011)
Merck Research Labs.
Inhibitory activity of novel kojic acid derivative containing trolox moiety on melanogenesis.
Bioorg Med Chem Lett 21: 7466-9 (2011)
Kyung Hee University Skin Biotechnology Center
Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
J Med Chem 55: 197-208 (2012)
Millennium Pharmaceuticals
Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators.
J Med Chem 54: 8541-54 (2011)
Merck Research Laboratories
Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90.
J Med Chem 54: 8592-604 (2011)
Universit£
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.
Bioorg Med Chem 19: 7603-11 (2011)
Ghent University
Pyrazolone-based anaplastic lymphoma kinase (ALK) inhibitors: control of selectivity by a benzyloxy group.
Bioorg Med Chem Lett 21: 7261-4 (2011)
Cephalon
Investigation of the diastereomerism of dihydrobenzoxathiin SERMs for ER alpha by molecular modeling.
Bioorg Med Chem Lett 21: 7298-305 (2011)
Zhejiang University
The discovery of novel cyclohexylamide CCR2 antagonists.
Bioorg Med Chem Lett 21: 7496-501 (2011)
Johnson & Johnson Pharmaceutical Research And Development
Discovery of 4-aminomethylphenylacetic acids as¿-secretase modulators via a scaffold design approach.
Bioorg Med Chem Lett 21: 7277-80 (2011)
Biogen Idec
Discovery, optimisation and in vivo evaluation of novel GPR119 agonists.
Bioorg Med Chem Lett 21: 7310-6 (2011)
Astrazeneca
Efficient synthesis of a novel m-phenylene derivative as a selective EP4 agonist inducing follicular growth and maturation in the ovary.
Bioorg Med Chem Lett 21: 7505-8 (2011)
Toray Industries
Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.
J Med Chem 54: 8681-92 (2011)
The Ohio State University
5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
J Med Chem 54: 8013-29 (2011)
Amira Pharmaceuticals
3D-Quantitative structure-activity relationship and docking studies of the tachykinin NK3 receptor.
Bioorg Med Chem Lett 21: 7405-11 (2011)
Northeast Ohio Medical University
Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity.
Bioorg Med Chem Lett 22: 738-42 (2011)
Boehringer Ingelheim Pharmaceuticals
Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.
Bioorg Med Chem Lett 21: 7321-4 (2011)
Universit£
Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters.
Bioorg Med Chem 19: 7551-8 (2011)
University Of New Orleans
Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand.
Bioorg Med Chem 19: 7435-40 (2011)
University Of Wisconsin School Of Medicine And Public Health
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase.
Bioorg Med Chem 19: 7507-18 (2011)
North-West University
Conformationally restricted analogs of the direct thrombin inhibitor FM 19.
Bioorg Med Chem 19: 7425-34 (2011)
University Of Michigan
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.
J Med Chem 54: 8299-304 (2011)
University Of Bologna
Synthesis and kinetic testing of new inhibitors for a metallo-?-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa.
Eur J Med Chem 46: 6075-82 (2011)
Helwan University
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.
Bioorg Med Chem 19: 6982-8 (2011)
University Of Oslo
a-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters.
J Enzyme Inhib Med Chem 27: 148-54 (2012)
Dumlupinar University
Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.
J Med Chem 54: 8461-70 (2011)
Instituto De Quimica Medica-Csic
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors.
J Med Chem 54: 8702-6 (2011)
Universit£
The arginine mimickingß-amino acidß³hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-basedß-tryptase inhibitors.
Bioorg Med Chem 19: 7236-43 (2011)
Universit£T Bielefeld
Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Bioorg Med Chem 19: 6977-81 (2011)
Medical University Of Lodz
Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.
Bioorg Med Chem Lett 21: 7295-7 (2011)
Sepuluh Nopember Institute Of Technology
Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
Bioorg Med Chem Lett 21: 7281-6 (2011)
Merck Frosst Centre For Therapeutic Research
The discovery of AZD9164, a novel muscarinic M3 antagonist.
Bioorg Med Chem Lett 21: 7440-6 (2011)
Astrazeneca
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.
Bioorg Med Chem Lett 21: 7489-95 (2011)
Glaxosmithkline
CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood.
Bioorg Med Chem Lett 21: 7291-4 (2011)
Glaxosmithkline
Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.
J Med Chem 54: 8563-73 (2011)
University Of British Columbia
Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.
ACS Med Chem Lett 2: 764-767 (2011)
TBA
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
Bioorg Med Chem Lett 21: 7474-8 (2011)
University Of North Carolina
Orally active zwitterionic factor Xa inhibitors with long duration of action.
Bioorg Med Chem Lett 21: 7337-43 (2011)
Daiichi Sankyo
Cucurbitane glucosides from the root of Machilus yaoshansis.
J Nat Prod 74: 2431-7 (2011)
State Key Laboratory Of Bioactive Substance And Function Of Natural Medicines, And Key Laboratory Of Bioactive Substances And Resources Utilization Of Chinese Herbal Medicine
Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor.
J Med Chem 54: 8278-88 (2011)
Universit£
Design, synthesis, and qualitative structure-activity evaluations of novelß-secretase inhibitors as potential Alzheimer's drug leads.
J Med Chem 54: 8373-85 (2011)
University Of Sharjah
Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.
Bioorg Med Chem 19: 6989-99 (2011)
Genkyotex
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.
Bioorg Med Chem 19: 7228-35 (2011)
Guangzhou Institute Of Biomedicine And Health
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.
Bioorg Med Chem 19: 7003-7 (2011)
Universit£
2,7-Pyrrolo[2,1-f][1,2,4]triazines as JAK2 inhibitors: modification of target structure to minimize reactive metabolite formation.
Bioorg Med Chem Lett 21: 7325-30 (2011)
Cephalon
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.
Bioorg Med Chem Lett 21: 7516-21 (2011)
Bristol-Myers Squibb
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.
Bioorg Med Chem Lett 21: 7416-20 (2011)
Astrazeneca R&D Boston
Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
J Med Chem 54: 8490-500 (2011)
Pfizer
Evaluation of 18F-labeled benzodioxine piperazine-based dopamine D4 receptor ligands: lipophilicity as a determinate of nonspecific binding.
J Med Chem 54: 8343-52 (2011)
Forschungszentrum J£Lich
Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
J Med Chem 54: 7860-83 (2011)
Johnson & Johnson Pharmaceutical Research & Development
Comprehensive analysis of kinase inhibitor selectivity.
Nat Biotechnol 29: 1046-51 (2011)
Ambit Biosciences
Triazole ring-opening leads to the discovery of potent nonsteroidal 17ß-hydroxysteroid dehydrogenase type 2 inhibitors.
Eur J Med Chem 46: 5978-90 (2011)
Saarland University
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Bioorg Med Chem 19: 7044-8 (2011)
Research Triangle Institute
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.
Bioorg Med Chem 19: 7181-5 (2011)
Slovak Academy Of Sciences
Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro.
Bioorg Med Chem 19: 7100-10 (2011)
Jilin University
1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase.
Bioorg Med Chem 19: 7262-9 (2011)
Beijing Institute Of Technology
Synthesis and docking study of 2-phenylaminopyrimidine Abl tyrosine kinase inhibitors.
Bioorg Med Chem Lett 21: 6964-8 (2011)
Beijing National Laboratory For Molecular Sciences
Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.
Bioorg Med Chem Lett 21: 6950-4 (2011)
Genzyme
Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway.
J Med Chem 54: 8471-89 (2011)
Georgia State University
Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.
Drug Metab Dispos 40: 276-82 (2012)
Astellas Pharma
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.
Bioorg Med Chem Lett 21: 7483-8 (2011)
Glaxosmithkline
Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.
Bioorg Med Chem Lett 21: 7089-93 (2011)
Monash University (Parkville Campus)
Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.
Bioorg Med Chem Lett 21: 7124-30 (2011)
Merck Research Laboratories
Discovery of new aminopyrimidine-based phosphoinositide 3-kinase beta (PI3Kß) inhibitors with selectivity over PI3Ka.
Bioorg Med Chem Lett 21: 6977-81 (2011)
Institute Of Science And Technology (Kaist)
Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.
Bioorg Med Chem Lett 21: 6955-9 (2011)
Vanderbilt University Medical Center
New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.
J Med Chem 54: 7986-99 (2011)
Universidad Complutense De Madrid
Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
J Med Chem 54: 8161-73 (2011)
Chemical Diversity Research Institute
Human UDP-glucuronosyltransferase isoforms involved in haloperidol glucuronidation and quantitative estimation of their contribution.
Drug Metab Dispos 40: 240-8 (2012)
Kanazawa University
Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.
Eur J Med Chem 46: 5949-58 (2011)
Zhejiang University
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
Bioorg Med Chem 19: 7120-8 (2011)
Southern Research Institute
Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors.
Bioorg Med Chem Lett 21: 6941-4 (2011)
Pfizer
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
J Med Chem 54: 8251-70 (2011)
Universitat Aut£Noma De Barcelona
Identification of novel CYP2A6 inhibitors by virtual screening.
Bioorg Med Chem 19: 7186-93 (2011)
University Of Eastern Finland
Design, synthesis and biological evaluation of peptidyl-vinylaminophosphonates as novel cysteine protease inhibitors.
Bioorg Med Chem 19: 7129-35 (2011)
National Chemical Laboratory (Csir-Ncl)
Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities.
Bioorg Med Chem 19: 7158-67 (2011)
Zhejiang University
Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Bioorg Med Chem Lett 21: 7001-5 (2011)
Amgen
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.
Eur J Med Chem 46: 5885-93 (2011)
Sun Yat-Sen University
Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.
Eur J Med Chem 46: 5970-7 (2011)
Zhejiang University
Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents.
Eur J Med Chem 46: 5763-8 (2011)
Jamia Hamdard (Hamdard University)
Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor.
Bioorg Med Chem 19: 7221-7 (2011)
Sanwa Kagaku Kenkyusho
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.
Bioorg Med Chem 19: 7168-80 (2011)
University Of Innsbruck
13,13-Dimethyl-des-C,D analogues of (20S)-1a,25-dihydroxy-2-methylene-19-norvitamin D3 (2MD): total synthesis, docking to the VDR, and biological evaluation.
Bioorg Med Chem 19: 7205-20 (2011)
University Of Wisconsin-Madison
Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
Eur J Med Chem 46: 6002-14 (2011)
Norwegian University Of Science And Technology
Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives.
Eur J Med Chem 46: 6104-11 (2011)
Facult£S Universitaires Notre-Dame De Paix
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.
Bioorg Med Chem Lett 21: 7180-4 (2011)
Scripps Florida
Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II).
Bioorg Med Chem Lett 21: 7113-8 (2011)
The Scripps Research Institute
Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2.
Bioorg Med Chem Lett 21: 7210-5 (2011)
The Scripps Research Institute
Spacer length effects on in vitro imaging and surface accessibility of fluorescent inhibitors of prostate specific membrane antigen.
Bioorg Med Chem Lett 21: 7013-6 (2011)
Washington State University
III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold.
Bioorg Med Chem Lett 21: 6982-6 (2011)
Merck Research Laboratories
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Bioorg Med Chem Lett 21: 7006-12 (2011)
Bristol-Myers Squibb Research And Development
Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.
J Med Chem 54: 8174-87 (2011)
Boehringer Ingelheim Pharmaceuticals
Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.
J Med Chem 54: 8228-32 (2011)
Sapienza University Of Rome
Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.
J Med Chem 54: 8289-98 (2011)
Instituto Superior T£Cnico
A small molecule that preferentially binds the closed conformation of Hsp90.
Bioorg Med Chem Lett 21: 7068-71 (2011)
San Diego State University
Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells.
Bioorg Med Chem 19: 6760-7 (2011)
Hanyang University
Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
Bioorg Med Chem 19: 6779-91 (2011)
University Of Innsbruck
New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors.
Eur J Med Chem 46: 5790-9 (2011)
Universit£
Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonists.
Bioorg Med Chem Lett 21: 7076-80 (2011)
Cephalon
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).
Bioorg Med Chem Lett 21: 7155-65 (2011)
Ansaris
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
Bioorg Med Chem Lett 21: 7094-8 (2011)
Rfs Pharma
Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening.
Bioorg Med Chem Lett 21: 7064-7 (2011)
University Of California
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
Bioorg Med Chem Lett 21: 7041-4 (2011)
University Of Cagliari
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.
J Nat Prod 74: 2362-70 (2011)
University Of Thessaly
Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors.
J Med Chem 54: 7962-73 (2011)
Kyoto Pharmaceutical University
Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand.
J Med Chem 54: 8078-84 (2011)
H. Lee Moffitt Cancer Center & Research Institute
Multidentate (18)F-polypegylated styrylpyridines as imaging agents for A? plaques in cerebral amyloid angiopathy (CAA).
J Med Chem 54: 8085-98 (2011)
University Of Pennsylvania
Lipophosphonoxins: new modular molecular structures with significant antibacterial properties.
J Med Chem 54: 7884-98 (2011)
Academy Of Sciences Of The Czech Republic V.V.I.
Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides.
J Med Chem 54: 8148-60 (2011)
University Of Kansas
Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor.
J Med Chem 54: 8195-206 (2011)
Vu University Amsterdam
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.
Eur J Med Chem 46: 5838-51 (2011)
University Of Santiago De Compostela
Selection of cyclic-peptide inhibitors targeting Aurora kinase A: problems and solutions.
Bioorg Med Chem 19: 6743-9 (2011)
University Of Arizona
Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.
Bioorg Med Chem Lett 21: 7072-5 (2011)
The Scripps Research Institute
Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
Bioorg Med Chem Lett 21: 7107-12 (2011)
The Scripps Research Institute
Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.
J Med Chem 54: 8136-47 (2011)
Vu University Amsterdam
Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.
J Med Chem 54: 8030-50 (2011)
Takeda Pharmaceutical
Identification of Inhibitors of NOD1-Induced Nuclear Factor-¿B Activation.
ACS Med Chem Lett 2: 780-785 (2011)
TBA
Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.
Bioorg Med Chem 19: 6750-9 (2011)
Jagiellonian University Medical College
Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit.
Bioorg Med Chem 19: 6906-18 (2011)
Princeton University
Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.
Bioorg Med Chem Lett 21: 7131-6 (2011)
Merck Research Laboratories
Synthesis of GSK3ß mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate.
Bioorg Med Chem Lett 21: 7166-9 (2011)
H. Lee Moffitt Cancer Center And Research Institute
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.
Bioorg Med Chem Lett 21: 7205-9 (2011)
Roche Research Center
Transformation of quercitols into 4-methylenecyclohex-5-ene-1,2,3-triol derivatives, precursors for the chemical chaperones N-octyl-4-epi-ß-valienamine (NOEV) and N-octyl-ß-valienamine (NOV).
Bioorg Med Chem Lett 21: 7189-92 (2011)
Hokko Chemical Industry
The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.
Bioorg Med Chem Lett 21: 7137-41 (2011)
University Of Victoria
Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases.
Bioorg Med Chem Lett 21: 7216-8 (2011)
Moscow State University
Usabamycins A-C: new anthramycin-type analogues from a marine-derived actinomycete.
Bioorg Med Chem Lett 21: 7099-101 (2011)
Nippon Suisan Kaisha
Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors.
Bioorg Med Chem Lett 21: 7185-8 (2011)
Korea Research Institute Of Chemical Technology
Synthesis and antimicrobial activity of brominated resorcinol dimers.
Bioorg Med Chem Lett 21: 7142-5 (2011)
University Of East Anglia
Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors.
Bioorg Med Chem 19: 6827-32 (2011)
Nanjing University
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.
Eur J Med Chem 46: 6119-30 (2011)
University Of Lisbon
Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors.
Eur J Med Chem 46: 5825-32 (2011)
National Organization For Drug Control & Research
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