Compile Data Set for Download or QSAR
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Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50040490
Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM50017721(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Affinity DataKi:  0.460nMAssay Description:Antagonist activity at 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  2nMAssay Description:Antagonist activity at 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2B(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2C(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  417nMAssay Description:Displacement of [3H]LSD from 5HT2C receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  1.96E+3nMAssay Description:Displacement of [3H]Ketanserin from 5HT2A receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 5A(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  3.30E+3nMAssay Description:Displacement of [3H]LSD from 5HT5A receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 6(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  6.21E+3nMAssay Description:Displacement of [3H]LSD from 5HT6 receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 7(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKi:  7.07E+3nMAssay Description:Displacement of [3H]LSD from 5HT7 receptor after 1.5 hrs by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 3(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetMast/stem cell growth factor receptor Kit(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  31nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 1(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  31nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetPlatelet-derived growth factor receptor beta(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  52nMAssay Description:Inhibition of RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetVascular endothelial growth factor receptor 2(Human)
National Institute of Biological Sciences

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  59nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)