Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50040857
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2204436 | CHEMBL2385894)
Affinity DataIC50:  190nMAssay Description:Negative allosteric modulation of human mGlu3 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50332963(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Affinity DataIC50:  270nMAssay Description:Negative allosteric modulation of mGlu3 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50332963(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Affinity DataIC50:  296nMAssay Description:Negative allosteric modulation of mGlu2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50:  660nMAssay Description:Negative allosteric modulation of mGlu3 assessed as inhibition of glutamate-induced calcium mobilization in presence of Galpha15 by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50:  1.48E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50:  1.50E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401085(CHEMBL2204446)
Affinity DataIC50:  2.04E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401085(CHEMBL2204446)
Affinity DataIC50:  2.10E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401088(CHEMBL2204439)
Affinity DataIC50:  2.45E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401088(CHEMBL2204439)
Affinity DataIC50:  2.50E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401085(CHEMBL2204446)
Affinity DataIC50:  3.24E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401090(CHEMBL2204437)
Affinity DataIC50:  3.80E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401090(CHEMBL2204437)
Affinity DataIC50:  3.80E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2204436 | CHEMBL2385894)
Affinity DataIC50:  4.20E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401089(CHEMBL2204438)
Affinity DataIC50:  5.00E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401089(CHEMBL2204438)
Affinity DataIC50:  5.01E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401085(CHEMBL2204446)
Affinity DataIC50:  5.49E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401087(CHEMBL2204440)
Affinity DataIC50:  5.70E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401087(CHEMBL2204440)
Affinity DataIC50:  5.75E+3nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu5 assessed as inhibition of glutamate-induced calcium mobilization by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401085(CHEMBL2204446)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401094(CHEMBL2204441)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401093(CHEMBL2204443)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401092(CHEMBL2204444)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu3 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337957((4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu3 assessed as assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2204436 | CHEMBL2385894)
Affinity DataIC50: >1.25E+4nMAssay Description:Negative allosteric modulation of human mGlu2 expressed in AV-12 cells in presence of glutamate EC90 concentration by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2204436 | CHEMBL2385894)
Affinity DataIC50:  1.70E+4nMAssay Description:Negative allosteric modulation of mGlu2 assessed as thaillium flux through GIRK channels by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50337957((4-hydroxypiperidin-1-yl)(4-(phenylethynyl)phenyl)...)
Affinity DataEC50:  270nMAssay Description:Positive allosteric modulation of rat mGlu5 expressed in HEK293 cells in presence of glutamate EC20 concentration by Fluo-2AM dye based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401086(CHEMBL2204445)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu5 assessed as potentiation of glutamate-induced calcium mobilization by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed