Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50039730
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318567BDBM50318567(2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiop...)
Affinity DataIC50: 4nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318567BDBM50318567(2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiop...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318567BDBM50318567(2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiop...)
Affinity DataIC50: 114nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataEC50:  200nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294836BDBM50294836(CHEMBL551506 | CHEMBL1956162 | 4-((1R,2S,6R,7S)-3,...)
Affinity DataEC50:  200nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294799BDBM50294799(N-(4-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-az...)
Affinity DataEC50:  1.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50382971BDBM50382971(CHEMBL2030486)
Affinity DataEC50:  2.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50318567BDBM50318567(2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiop...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294816BDBM50294816(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294813BDBM50294813(N-Benzyl-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo...)
Affinity DataEC50:  2.00E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294819BDBM50294819(N-Cyclohexyl-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tric...)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50382969BDBM50382969(CHEMBL2030485)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human PARP2 using NAD+ as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Abo Akademi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50294835BDBM50294835(CHEMBL562310 | CHEMBL551505 | N-(Quinolin-8-yl)-4-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP1 using NAD+ as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed