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N-Glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5641-5 (2013)
Mitsubishi Tanabe Pharma
Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5566-70 (2013)
Mallinckrodt Pharmaceuticals
Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5630-3 (2013)
Nanjing University of Technology
Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7939-50 (2013)
Mcgill University
Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 3: 976-981 (2012)
University of Wisconsin-Milwaukee
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 412-21 (2013)
Universit£
Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3ß (GSK-3ß) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 361-71 (2013)
Zhejiang University
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 333-8 (2013)
Universit£
Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 312-20 (2013)
First Affiliated Hospital of Guangzhou Medical University
Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5721-6 (2013)
University of Zurich
Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6642-9 (2013)
Eutropics Pharmaceuticals
Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6665-73 (2013)
Kyoto Pharmaceutical University
Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6771-7 (2013)
University of Kentucky
Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5684-8 (2013)
Bristol-Myers Squibb
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5614-8 (2013)
Sapienza University of Rome
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5674-9 (2013)
Northwestern University
Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5624-9 (2013)
Leo Pharma
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5646-9 (2013)
University of Florida
Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6804-20 (2013)
Chinese Academy of Sciences
Emerging technologies for metabolite generation and structural diversification.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5471-83 (2013)
Abbvie Bioresearch Center
Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7552-63 (2013)
Institute of Technology (Eth) Zurich
Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6917-34 (2013)
Istituto Italiano Di Tecnologia
Synthesis and enzymatic evaluation of phosphoramidon and itsß anomer: Anomerization ofa-l-rhamnose triacetate upon phosphitylation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6778-87 (2013)
Jiangxi Science and Technology Normal University
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 291-300 (2013)
Tehran University of Medical Sciences
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 260-9 (2013)
Tehran University of Medical Sciences
Phosphodiesterase inhibitors. Part 6: design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5311-6 (2013)
Kyorin Pharmaceutical
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5290-4 (2013)
Universit£
Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5267-9 (2013)
Universit£
Modulation of aldose reductase inhibition by halogen bond tuning.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 2484-92 (2013)
Academy of Sciences of The Czech Republic
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5963-72 (2013)
University of Southern California
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7615-24 (2013)
Ume£
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes ass receptor ligands with potential neuroprotective effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6038-52 (2013)
The University of Sydney
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selectiveß-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloidß-peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5300-6 (2013)
Novartis Pharma
Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5397-400 (2013)
Leopold-Franzens-Universit£T
The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 233-43 (2013)
Seoul National University
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7289-301 (2013)
Nagasaki University
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7110-9 (2013)
Pfizer
Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5415-20 (2013)
Emory University
Design and synthesis of novel 3-substituted-indole derivatives as selective H3 receptor antagonists and potent free radical scavengers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5936-44 (2013)
Zhejiang University
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6053-62 (2013)
H. Lundbeck
Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 2501-8 (2013)
Rutgers University
Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 9369-402 (2014)
Janssen Research and Development
Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 647-650 (2013)
University of California
Synthesis, molecular docking and kinetic properties of ?-hydroxy-?-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 212-21 (2013)
Jishou University
Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 167-77 (2013)
Universit£
2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 150-66 (2013)
Universidad De Valencia
Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 139-49 (2013)
Universit£
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 72-80 (2013)
Agency For Science, Technology and Research (A*Star)
Fragment-based discovery of focal adhesion kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5401-9 (2013)
Merck
Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5385-8 (2013)
Fudan University
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5361-6 (2013)
Merck Research Laboratories
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5437-41 (2013)
Glaxosmithkline
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 58-71 (2013)
Sun Yat-Sen University
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7431-41 (2013)
Sapienza University of Rome
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7190-200 (2013)
University of Toronto Mississauga
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7396-415 (2013)
Actelion Pharmaceuticals
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5973-82 (2013)
Birla Institute of Technology
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6803-18 (2013)
Memorial Sloan-Kettering Cancer Center
Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7302-11 (2013)
Max Planck Research Unit For Enzymology of Protein Folding
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7201-11 (2013)
Millennium Pharmaceuticals
Structure of thes1 receptor and its ligand binding site.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 9809-19 (2013)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7590-607 (2013)
Novartis Institutes For Biomedical Research
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7222-31 (2013)
Kyoto Prefectural University of Medicine
Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7343-57 (2013)
Bristol-Myers Squibb
Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6084-91 (2013)
Soochow University
Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7324-33 (2013)
Gilead Sciences
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 29105-14 (2013)
The Scripps Research Institute
Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5983-94 (2013)
Takeda Pharmaceutical
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7212-21 (2013)
Case Western Reserve University
Discovery of HIV-1 integrase inhibitors: pharmacophore mapping, virtual screening, molecular docking, synthesis, and biological evaluation.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 83: 154-66 (2014)
Nirma University
Antioxidant, a-glucosidase and xanthine oxidase inhibitory activity of bioactive compounds from maize (Zea mays L.).![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 83: 119-25 (2014)
Srtm University
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Toxicol Sci 136: 216-41 (2013)
Amgen
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 28641-55 (2013)
University of Michigan Medical School
?2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5376-81 (2013)
Medical University of South Carolina
Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6022-37 (2013)
Purdue University
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 6077-83 (2013)
University of Delhi
Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5410-4 (2013)
Pfizer
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5442-7 (2013)
Ironwood Pharmaceuticals
Testing the substrate-envelope hypothesis with designed pairs of compounds.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 2433-41 (2013)
Massachusetts Institute of Technology
Structure activity relationship studies of 17-cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinity and function.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5045-8 (2013)
Virginia Commonwealth University
Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7243-59 (2013)
Janssen Pharmaceutica
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6696-708 (2013)
California Nanosystems Institute
Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6792-802 (2013)
Purdue University
Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6651-65 (2013)
Pfizer
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIa) inhibitors as anti hepatitis C (HCV) agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 57: 2091-106 (2014)
Glaxosmithkline
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5061-5 (2013)
Chinese Academy of Sciences
KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 57: 249-77 (2014)
Vu University Amsterdam
Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1475-84 (2013)
Fudan University
Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6901-16 (2013)
Research Triangle Institute
Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 27836-48 (2013)
Oregon Health and Science University
Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5679-87 (2013)
Zhejiang University
Synthesis, enzyme kinetics and computational evaluation of N-(ß-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5738-47 (2013)
University of Debrecen
Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5140-4 (2013)
Hokkaido University
Selectivity data: assessment, predictions, concordance, and implications.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6991-7002 (2013)
Eli Lilly
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 28217-29 (2013)
National Institutes of Health, National Institutes of Health Biomedical Research Center
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 28195-206 (2013)
Glaxosmithkline
Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 68: 1-9 (2013)
Nanjing University
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5091-6 (2013)
Vanderbilt University Medical Center
A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5097-104 (2013)
Genentech
N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5082-5 (2013)
Clinical Research Institute of Montreal
Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aß aggregation and antioxidant activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5830-40 (2013)
Sun Yat-Sen University
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5673-8 (2013)
National Institute of Diabetes and Digestive and Kidney Diseases
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7025-48 (2013)
Astrazeneca
SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 517-521 (2013)
University of Texas Southwestern Medical Center
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 28733-42 (2013)
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School of Lyon
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5725-37 (2013)
Takeda Pharmaceutical
Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5150-4 (2013)
Kyung Hee University
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5239-43 (2013)
Bristol-Myers Squibb Research & Development
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5128-30 (2013)
Universit£
Cell-based medicinal chemistry optimization of high-throughput screening (HTS) hits for orally active antimalarials. Part 1: challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7741-9 (2013)
Calibr
Development of Mycobacterium tuberculosis whole cell screening hits as potential antituberculosis agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7755-60 (2013)
Global Alliance For Tb Drug Development (Tb Alliance)
Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7750-4 (2013)
University of Cape Town
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6681-95 (2013)
University of Eastern Finland
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5782-93 (2013)
National Institute of Pharmaceutical Education and Research
Metallo-?-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5841-50 (2013)
Meiji Seika Pharma
Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5707-24 (2013)
The Institute of Cancer Research
Discovery of highly potent and selective D4 ligands by interactive SAR study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5077-81 (2013)
German University In Cairo
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5145-9 (2013)
Riken
Ligand-protein interactions of selective casein kinase 1d inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6819-28 (2013)
Pfizer
Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6761-74 (2013)
Helmholtz-Institute For Pharmaceutical Research Saarland
Polypharmacology - foe or friend?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 8955-71 (2013)
F. Hoffmann-La Roche
Novel 1H-pyrrolo[2,3-b]pyridine derivative nortopsentin analogues: synthesis and antitumor activity in peritoneal mesothelioma experimental models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7060-72 (2013)
Universit£
Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chembiochem 14: 1611-9 (2013)
Fondazione Istituto Italiano Di Tecnologia
Inhibitors of switch kinase 'spleen tyrosine kinase' in inflammation and immune-mediated disorders: a review.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 434-46 (2013)
Punjabi University
Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5448-51 (2013)
Bristol-Myers Squibb
Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5217-22 (2013)
Activx Biosciences
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5195-8 (2013)
Vanderbilt University
Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 24: 1239-42 (2014)
Janssen Research and Development
The discovery of inhibitors of Fas-mediated cell death pathway using the combined computational method.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5155-64 (2013)
Chungnam National University
Novel selective inhibitors of aminopeptidases that generate antigenic peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4832-6 (2013)
University of California San Diego
Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5876-85 (2013)
University of Dundee
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 469-75 (2014)
University of Calgary
Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1393-8 (2013)
National Institute of Pharmaceutical Education and Research (NIPER)
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6954-6966 (2013)
Duke University
Discovery and characterization of carbamothioylacrylamides as EP![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 616-621 (2013)
Emory University
Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 601-605 (2013)
Vanderbilt University School of Medicine
Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5407-13 (2013)
Universit£
PIF-pocket as a target for C. albicans Pkh selective inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 2283-92 (2013)
Universit£Tsklinikum Frankfurt
Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5799-805 (2013)
Dumlup?Nar University
Adipogenetic effects of retrofractamide A derivatives in 3T3-L1 cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4813-6 (2013)
Kyoto Pharmaceutical University
Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5170-3 (2013)
Institute of Nuclear Medicine
Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6434-56 (2013)
Emory University
Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4790-3 (2013)
Translational Drug Development
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6478-94 (2013)
Takeda Pharmaceutical
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6775-91 (2013)
National Taiwan University
Peripherally restricted CB1 receptor blockers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4751-60 (2013)
Jenrin Discovery
6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective ?1D-adrenoceptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6402-12 (2013)
Universit£
Quinazoline-based multi-tyrosine kinase inhibitors: synthesis, modeling, antitumor and antiangiogenic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 373-83 (2013)
University of Padova
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 2145-50 (2013)
Massachusetts General Hospital and Harvard Medical School
Binding of (5S)-penicilloic acid to penicillin binding protein 3.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 2112-6 (2013)
University of Oxford
Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4779-84 (2013)
Lg Life Sciences
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4975-8 (2013)
University of Arizona
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4875-85 (2013)
Genentech
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7015-24 (2013)
Astrazeneca
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6858-70 (2013)
University Hospital M£Nster
Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6871-85 (2013)
University of Kansas
Resistance by allostery: a novel perspective for eg5-targeted drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6314-6 (2013)
Korea Institute of Science and Technology
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 26926-43 (2013)
Genentech
Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4904-13 (2013)
University of Cape Town
Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4923-7 (2013)
University of Maryland
Biochemical characterization of the chloroplastic ß-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze".![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 500-4 (2014)
Istituto Di Biostrutture E Bioimmagini-Cnr
Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6583-92 (2013)
Wake Forest University
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6829-44 (2013)
Duquesne University
Toward drugs for protease-activated receptor 2 (PAR2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7477-97 (2013)
The University of Queensland
The adenosine A(2A) antagonistic properties of selected C8-substituted xanthines.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Bioorg Chem 49: 49-58 (2013)
North-West University, Private Bag X6001, Potchefstroom 2520, South Africa
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4928-37 (2013)
Ege University
Selective orexin receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4761-9 (2013)
Janssen Pharmaceutica
Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4886-91 (2013)
United Arab Emirates University
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4862-6 (2013)
University of New South Wales
Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4774-8 (2013)
Okayama University
1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4951-7 (2013)
Aristotle University of Thessaloniki
Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5188-97 (2013)
Mcphs University
Design and synthesis of bicyclic heterocycles as potent¿-secretase modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4794-800 (2013)
Janssen Pharmaceutica
Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5029-38 (2013)
University of Arizona
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7084-99 (2013)
University of Bonn
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4938-50 (2013)
Hokkaido University
Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5004-11 (2013)
Queen'S University of Belfast
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5907-22 (2013)
Daiichi Sankyo
3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4824-7 (2013)
Universidad De Valencia
A novel necroptosis inhibitor-necrostatin-21 and its SAR study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4903-6 (2013)
Chinese Academy of Sciences
QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at thea4ß2 anda3ß4 nicotinic acetylcholine receptors (nAChRs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4842-7 (2013)
Targacept
Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4837-41 (2013)
Institutes For Pharmaceutical Discovery
The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4979-84 (2013)
Glaxosmithkline
Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6613-25 (2013)
Probiodrug
Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 26908-13 (2013)
Mcgill University
Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4867-9 (2013)
University of Utah
Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4911-8 (2013)
Aurigene Discovery Technologies
Access to 7?-analogs of codeine with mixed ?/? agonist activity via 6,7-?-epoxide opening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4870-4 (2013)
University of Texas At Austin
3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 344-51 (2013)
University of Siena
Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 335-43 (2013)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse and Alcoholism
Rapid modifications of N-substitution in iminosugars: development of newß-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5021-8 (2013)
Genomics Research Center
A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 8972-83 (2013)
Baylor College of Medicine
Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7049-59 (2013)
Novartis Institutes For Biomedical Research
Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6457-66 (2013)
Karolinska Institutet
Synthesis and evaluation of novel radioligands for positron emission tomography imaging of the orexin-2 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6371-85 (2013)
Eisai
Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4857-61 (2013)
Abbvie
Absolute configuration of acremoxanthone C, a potent calmodulin inhibitor from Purpureocillium lilacinum.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1454-60 (2013)
Universidad Nacional Aut£Noma De M£Xico
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6317-29 (2013)
The Beatson Institute For Cancer Research
A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 325-34 (2013)
National University of Singapore
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 269-79 (2013)
University of Salerno
Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 230-42 (2013)
Karadeniz Technical University
An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 221-9 (2013)
Universiti Sains Malaysia
Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5081-97 (2013)
Pfizer
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5014-21 (2013)
Genentech
Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Biochemistry 52: 5133-44 (2013)
The Scripps Research Institute
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6022-32 (2013)
Saarland University
Lead identification of novel and selective TYK2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 175-87 (2013)
Genentech
Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5145-53 (2013)
University of Catania
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5168-74 (2013)
Birla Institute of Technology
Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5271-4 (2013)
University of Groningen
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5323-31 (2013)
Northwestern University
Structure activity relationship study of benzo[d]thiazol-2(3H)one baseds receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5011-3 (2013)
University of Mississippi
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4944-7 (2013)
Chinese Academy of Sciences
Identification of GNE-293, a potent and selective PI3Kd inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4953-9 (2013)
Genentech
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Cell Chem Biol 56: 8224-56 (2013)
Arena Pharmaceuticals
Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well asß²- epi-Azumamide E andß³-epi-Azumamide E.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6512-20 (2013)
Technical University of Denmark
Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 26235-45 (2013)
Wageningen University
Novelß-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4948-52 (2013)
Shandong University
Selected furanochalcones as inhibitors of monoamine oxidase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4985-9 (2013)
North-West University
Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5076-80 (2013)
Chinese Academy of Sciences
2-Substituted 4-hydroxybutanamides as potential inhibitors of ?-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5154-67 (2013)
Jagiellonian University Medical College
Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5118-29 (2013)
University of Arizona
5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5130-8 (2013)
Latvian Association of Human Genetics
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6101-7 (2013)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6413-33 (2013)
Forma Therapeutics
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6352-70 (2013)
University of Manchester
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4674-9 (2013)
Elan Pharmaceuticals
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4511-6 (2013)
Osi Pharmaceuticals
Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4493-500 (2013)
Merz Pharmaceuticals
Exploring the orthosteric binding site of the ?-aminobutyric acid type A receptor using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6536-40 (2013)
University of Copenhagen
1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6386-401 (2013)
Newcastle University
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6593-612 (2013)
University of Texas-Pan American
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 25362-74 (2013)
University of Queensland
Synthesis and biological evaluation of pyrazolo[4,3-d]pyrimidine analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 152-7 (2013)
Sichuan University
Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 115-26 (2013)
University of Bonn
The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 81-9 (2013)
Academy of Sciences of The Czech Republic
Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4597-601 (2013)
Da Universidade De S£O Paulo
A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4523-7 (2013)
Addex Therapeutics
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4501-5 (2013)
Takeda California
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4517-22 (2013)
Osi Pharmaceuticals
1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4547-51 (2013)
Universit£
One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5218-27 (2013)
University of Bath
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5383-94 (2013)
Universit£
Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 595-602 (2013)
Tianjin Medical University
Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17ß-hydroxysteroid dehydrogenase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5261-70 (2013)
Astellas Pharma
Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 5244-8 (2013)
Bristol-Myers Squibb R & D
Structure guided design of a series of sphingosine kinase (SphK) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4608-16 (2013)
Amgen
1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4685-91 (2013)
Sanofi Deutschland
Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4552-6 (2013)
University of Paris
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5901-16 (2013)
Glaxosmithkline Research & Development
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6259-72 (2013)
Universit£
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6495-511 (2013)
Novartis Institutes For Biomedical Research
Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5228-32 (2013)
Bezmialem Vakif University
Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4591-6 (2013)
Astrazeneca
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 23858-67 (2013)
University of Iowa
Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 24656-65 (2013)
Université Montpellier 1
Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 67: 64-74 (2013)
Instituto De Qu£Mica Org£Nica General (Csic)
Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5246-60 (2013)
Shenyang Pharmaceutical University
Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4562-6 (2013)
Northwest Agriculture & Forestry University
LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5673-4 (2014)
University of Michigan Comprehensive Cancer Center
Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5744-56 (2014)
Astellas Pharma
Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 526-30 (2013)
Aston University
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6054-68 (2013)
University of Illinois College of Pharmacy
Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 438-49 (2013)
Forman Christian College (A Chartered University)
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4571-8 (2013)
Pfizer
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4627-32 (2013)
F. Hoffmann-La Roche
Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5316-22 (2013)
National Institute of Radiological Sciences
Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5297-309 (2013)
The University of Tokyo
Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4567-70 (2013)
National Institute of Radiological Sciences
The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6069-87 (2013)
Entremed
A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6234-47 (2013)
Palack£
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6156-74 (2013)
University College London
Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 25387-99 (2013)
University of Manchester
Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 372-9 (2013)
Manipal College of Pharmaceutical Sciences
DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chembiochem 14: 1309-15 (2013)
The Johns Hopkins University
Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5964-5973 (2013)
Universit£
Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5917-30 (2014)
Fondazione Istituto Italiano Di Tecnologia
Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5339-54 (2013)
China Pharmaceutical University
Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4696-700 (2013)
Korea Institute of Science & Technology (Kist)
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4652-6 (2013)
Novartis Institutes For Biomedical Research
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6190-9 (2013)
Uppsala University
Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M(1) and M(4) muscarinic acetylcholine receptors agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4644-7 (2013)
Dainippon Sumitomo Pharma
Synthesis and in vivo evaluation of [(18)F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([(18)F]FECUMI-101) as an imaging probe for 5-HT1A receptor agonist in nonhuman primates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5598-604 (2013)
Columbia University Medical Center
Autotaxin inhibition: development and application of computational tools to identify site-selective lead compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5548-60 (2013)
The University of Memphis
Antiproliferative activity on human prostate carcinoma cell lines of new peptidomimetics containing the spiroazepinoindolinone scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5470-9 (2013)
Universit£
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5488-502 (2013)
Takeda Pharmaceutical
4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5860-71 (2014)
University of Belgrade
A class of sulfonamides with strong inhibitory action against the ?-carbonic anhydrase from Trypanosoma cruzi.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5773-81 (2013)
Istanbul University
3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5275-87 (2014)
Naval Research Laboratories
ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 456-459 (2013)
University of California
MICE models: superior to the HERG model in predicting Torsade de Pointes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Sci Rep 3: (2013)
Chantest
Quercitylcinnamates, a new series of antidiabetic bioconjugates possessinga-glucosidase inhibition and antioxidant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 296-304 (2013)
Chulalongkorn University
Modulation ofavß3- anda5ß1-integrin-mediated adhesion by dehydro-ß-amino acids containing peptidomimetics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 258-68 (2013)
University of Bologna
Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5461-9 (2013)
University of Montpellier
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5480-7 (2013)
Korea Institute of Science and Technology
Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5451-60 (2013)
Banaras Hindu University
Investigations on synthesis and structure elucidation of novel [1,2,4]triazolo[1,2-a]pyridazine-1-thiones and their inhibitory activity against inducible nitric oxide synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5518-31 (2013)
Ernst-Moritz-Arndt University Greifswald
Synthesis anda-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-ß-d-glucopyranosides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5442-50 (2013)
Xi'An Jiaotong University
A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5618-28 (2013)
University of Toronto
Hydantoin based inhibitors of MMP13--discovery of AZD6605.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4705-12 (2013)
Astrazeneca
Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4713-8 (2013)
Korea Research Institute of Chemical Technology
Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5573-82 (2013)
Ewha Womans University
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5629-46 (2013)
Industrial Research
C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 5561-72 (2013)
Mitsubishi Tanabe Pharma
Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae ß-carbonic anhydrase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 495-9 (2014)
Ataturk University
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5979-83 (2014)
Roche Research Center
2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5940-8 (2014)
Merck Research Laboratories
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5247-60 (2014)
National Health Research Institutes
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 221-7 (2013)
Sapienza University of Rome
Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: synthesis and neuropharmacology.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 211-20 (2013)
Birla Institute of Technology & Science - Pilani
Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4292-6 (2013)
National Institute of Health Sciences
3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for monoamine transporters.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4404-7 (2013)
University of New Orleans
Discovery of triazines as potent, selective and orally active PDE4 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4308-14 (2013)
Biocrea
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1064-70 (2013)
University of London
Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4319-23 (2013)
Kyoto University
3'-Oxo-, amino-, thio- and sulfone-acetic acid modified thymidines: effect of increased acidity on ribonuclease A inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4634-45 (2013)
Institute of Technology Kharagpur
Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6216-33 (2013)
Washington University
Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4362-6 (2013)
Wenzhou Medical College
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5843-59 (2014)
Sun Yat-Sen University
Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 193-203 (2013)
University of Concepcion
Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide ?-neoendorphin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4347-50 (2013)
Memorial Sloan-Kettering Cancer Center
Pin1 inhibitors: Pitfalls, progress and cellular pharmacology.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4283-91 (2013)
Horizon Discovery
11ß-HSD1 inhibitors from Walsura cochinchinensis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1319-27 (2013)
Chinese Academy of Sciences
Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5722-33 (2013)
Lilly Research Laboratories
Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5395-406 (2014)
Lunam Universit£
Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 4: 822-826 (2013)
Baylor College of Medicine
Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 542-546 (2013)
Baylor College of Medicine
L-Aminoacyl-triazine derivatives are isoform-selective PI3K? inhibitors that target non-conserved Asp862 of PI3K?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 206-210 (2013)
Monash University (Parkville Campus)
Site-specific inhibitory mechanism for amyloid ß42 aggregation by catechol-type flavonoids targeting the Lys residues.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 23212-24 (2013)
Kyoto University
Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 135-45 (2013)
King Saud University
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 122-34 (2013)
Universidade Federal Do Rio De Janeiro
Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 82-90 (2013)
China Pharmaceutical University
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 56-68 (2013)
University of Florence
Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4477-84 (2013)
Chungbuk National University
Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4441-6 (2013)
University of California
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4662-9 (2013)
The Ohio State University
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4336-41 (2013)
University of Waterloo
Vialinin A is a ubiquitin-specific peptidase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4328-31 (2013)
Tokyo University of Agriculture
Anion inhibition studies of the ?-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4472-6 (2013)
University of Tampere and Tampere University Hospital
Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4530-40 (2013)
University of Pennsylvania
Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4324-7 (2013)
Korea Advanced Institute of Science and Technology
Design, synthesis and biological studies of novel tubulin inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4465-8 (2013)
The Ohio State University
Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5949-63 (2014)
National Institute of Diabetes and Digestive and Kidney Diseases
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5456-63 (2013)
Universit£
Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-??6 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4614-27 (2013)
Chemical Diversity Research Institute (Cdri)
Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4526-9 (2013)
Bioprojet-Biotech
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4419-23 (2013)
Jagiellonian University Medical College
Identification of potent Yes1 kinase inhibitors using a library screening approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4398-403 (2013)
Frederick National Laboratory For Cancer Research
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 22-31 (2013)
Sun Yat-Sen University
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5782-96 (2013)
Georgia Institute of Technology
A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5553-61 (2014)
University of Michigan
Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 66: 1-11 (2013)
Nanjing University
Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4575-80 (2013)
Universit£
Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4485-93 (2013)
Csir-Indian Institute of Chemical Technology
Orally available and efficaciousa4ß1/a4ß7 integrin inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4370-3 (2013)
Elan Pharmaceuticals
Phosphinic acid-based inhibitors of tubulin polyglutamylases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4408-12 (2013)
University of British Columbia
Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4388-92 (2013)
Merck Research Laboratories
Aeruginosins from a Microcystis sp. bloom material collected in Varanasi, India.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1187-90 (2013)
Tel-Aviv University
New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chembiochem 14: 1239-47 (2013)
Nankai University
Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at kappa-opioid receptors in striatal neurons.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 22387-98 (2013)
The Scripps Research Institute
Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4381-7 (2013)
Osi Pharmaceuticals
Rationally designed sulfamides as glutamate carboxypeptidase II inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 612-9 (2013)
Washington State University At Pullman
Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5757-72 (2014)
Technical University of Dortmund
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 3: 720-724 (2012)
Baylor University
Synthesis of N-substituted acyclicß-amino acids and their investigation as GABA uptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 487-99 (2013)
Zentrum F£R Pharmaforschung
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 477-86 (2013)
East China University of Science and Technology
Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 464-76 (2013)
University of Salerno
Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4037-43 (2013)
Lundbeck Research Usa
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4581-90 (2013)
Kurukshetra University
Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4044-7 (2013)
Sanofi Us
Design, synthesis and structure-activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4026-30 (2013)
Astrazeneca
A highly catalytically active¿-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4067-71 (2013)
Istituto Di Biochimica Delle Proteine-Cnr
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4459-64 (2013)
Amgen
Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4185-90 (2013)
Korea University
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4600-13 (2013)
Takeda Pharmaceutical
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4502-10 (2013)
Universit£
Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4091-5 (2013)
Menarini Ricerche
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4085-90 (2013)
Novartis Institutes For Biomedical Research
Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERa-selective antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4031-6 (2013)
The University of Tokyo
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4132-40 (2013)
Boehringer Ingelheim (Canada)
Synthesis and changes in affinity for NOP and opioid receptors of novel hexapeptides containing ?(2)-tryptophan analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4052-5 (2013)
Bulgarian Academy of Sciences
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4559-69 (2013)
Universidade T£Cnica De Lisboa
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5514-40 (2014)
The Walter and Eliza Hall Institute of Medical Research
Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5601-12 (2013)
Shanghai Institute of Materia Medica
Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrinaIIbß3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4646-61 (2013)
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4730-43 (2013)
The Ohio State University
Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4072-5 (2013)
Astex Pharmaceuticals
The discovery of potent selective NPY Y(2) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4141-4 (2013)
Janssen Research and Development
Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4210-5 (2013)
Theravance
Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4714-29 (2013)
Takeda Pharmaceutical
Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1882-7 (2013)
University of California
?-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5626-30 (2013)
University of Sydney
A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1747-54 (2013)
The Scripps Research Institute
Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4938-52 (2013)
Bar-Ilan University
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5335-50 (2014)
Bar-Ilan University
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5562-86 (2013)
Icahn School of Medicine At Mount Sinai
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 403-14 (2013)
Chinese Academy of Sciences
Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 360-75 (2013)
Astrazeneca
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4107-11 (2013)
Bristol-Myers Squibb Research and Development
Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4099-101 (2013)
Seoul National University
New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4248-52 (2013)
University of Monastir
Synthesis and evaluation of a conditionally-silent agonist for thea7 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4145-9 (2013)
University of Florida
The identification of novel p38? isoform selective kinase inhibitors having an unprecedented p38? binding mode.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4120-6 (2013)
Bristol-Myers Squibb Pharmaceutical Research Institute
Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4112-6 (2013)
University of Georgia
Synthesis and acrosin inhibitory activities of 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4177-84 (2013)
Second Military Medical University
Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Biochemistry 52: 4474-81 (2013)
University of California Irvine
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5382-94 (2014)
Universit£
2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4206-9 (2013)
Bristol-Myers Squibb
De novo tyrosinase inhibitor: 4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4172-6 (2013)
Pusan National University
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4253-7 (2013)
Sanford-Burnham Medical Research Institute
Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4216-20 (2013)
Hoffmann-La Roche
Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1105-12 (2013)
Universit£
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1698-703 (2013)
Ume£
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5675-90 (2014)
Genomics Institute of The Novartis Research Foundation
An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5464-72 (2013)
Novartis Institutes For Biomedical Research
The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 23488-504 (2013)
University of Notre Dame
Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4132-42 (2013)
Universidad De Granada
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4102-11 (2013)
Clermont Universit£
BACE1 inhibitors: a head group scan on a series of amides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4239-43 (2013)
F. Hoffmann-La Roche
Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 337-47 (2013)
Piramal Enterprises
Stereoselective synthesis and anti-proliferative effects on prostate cancer evaluation of 5-substituted-3,4-diphenylfuran-2-ones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 323-36 (2013)
Henan University of Traditional Chinese Medicine
Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4953-65 (2013)
Uppsala University
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5495-504 (2014)
University of Illinois At Chicago
Thes2 receptor: a novel protein for the imaging and treatment of cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7137-60 (2013)
Washington University
Discovery of new PPAR? agonists based on arylopeptoids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 4162-5 (2013)
University of Copenhagen
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4611-8 (2013)
Purdue University
Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5130-41 (2013)
Friedrich-Alexander University
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 256-75 (2013)
Academy of Sciences of The Czech Republic
1-substituted apomorphines as potent dopamine agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4143-50 (2013)
University of Tartu
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3713-8 (2013)
Vanderbilt University Medical Center
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3709-12 (2013)
Wichita State University
Discovery of non-LBD inhibitor for androgen receptor by structure-guide design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3887-90 (2013)
Korea Research Institute of Chemical Technology
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3841-7 (2013)
Boehringer Ingelheim (Canada)
Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3814-7 (2013)
Bristol-Myers Squibb Research and Development
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3741-8 (2013)
Novartis Institutes For Biomedical Research
Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3769-74 (2013)
University of Science and Technology
Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3802-5 (2013)
Kyoto University
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3732-7 (2013)
University of California
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3728-31 (2013)
Universit£
Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5115-29 (2013)
University of Illinois At Chicago
Quantitative analysis of histone demethylase probes using fluorescence polarization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5198-202 (2013)
University of Colorado
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 240-8 (2013)
Madurai Kamaraj University
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4378-87 (2013)
Durham University
Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3719-22 (2013)
Virginia Commonwealth University
The development of CNS-active LRRK2 inhibitors using property-directed optimisation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3690-6 (2013)
The University of Sydney
Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4899-911 (2013)
Actelion Pharmaceuticals
Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1775-84 (2013)
University of Konstanz
Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4233-49 (2013)
Asubio Pharma
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4218-24 (2013)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4201-9 (2013)
Kyoto University
Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3857-63 (2013)
Actelion Pharmaceuticals
Metabolites from Microcystis aeruginosa bloom material collected at a water reservoir near Kibbutz Hafetz Haim, Israel.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 1196-200 (2013)
Tel-Aviv University
Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5151-72 (2013)
Monash University
Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5059-70 (2013)
Virginia Commonwealth University
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5208-12 (2013)
Vanderbilt University Medical Center
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5182-97 (2013)
University of Bonn
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4990-5008 (2013)
Indiana University School of Medicine
Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4880-98 (2013)
University of Maryland
Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4351-7 (2013)
Centre For Addiction and Mental Health
The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3848-51 (2013)
Takeda Pharmaceutical
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3798-801 (2013)
Kitasato University
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 629-37 (2013)
Drug Discovery Laboratory
Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5033-47 (2013)
Ibitecs, Cea
Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4975-89 (2013)
Universit£
A thienopyrimidine derivative induces growth inhibition and apoptosis in human cancer cell lines via inhibiting Aurora B kinase activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 151-7 (2013)
Fudan University
Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker ?-KIIIA and its selenopeptide analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 144-50 (2013)
University of Gdansk
Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 134-43 (2013)
Fudan University
Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3891-5 (2013)
Shenyang Pharmaceutical University
The discovery of BMS-457, a potent and selective CCR1 antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3833-40 (2013)
Bristol-Myers Squibb
Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3826-32 (2013)
College of Pharmacy
Membrane anchoring¿-secretase modulators with terpene-derived moieties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3852-6 (2013)
Technische Universit£T Darmstadt
Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3822-5 (2013)
Dalhousie University
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3949-57 (2013)
University of W£Rzburg
1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4288-95 (2013)
University of Alberta
Indazoles as potential c-Met inhibitors: design, synthesis and molecular docking studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 112-8 (2013)
Guangdong Pharmaceutical University
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4320-42 (2013)
Amgen
Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme-Product Complex.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Biochemistry 52: 4217-28 (2013)
Stony Brook University
Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4482-96 (2013)
Universit£
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 51-9 (2013)
Jamia Hamdard (Hamdard University)
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3927-34 (2013)
Targacept
In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3901-4 (2013)
Chiba University
Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4224-35 (2013)
The Johns Hopkins University
Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 41-50 (2013)
University of Camerino
Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 32-40 (2013)
University of Liege
Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 65: 1-11 (2013)
National University of Singapore
Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4266-78 (2013)
City of Hope National Medical Center
Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4365-73 (2013)
Northwestern University
Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1713-21 (2013)
The University of Tokyo
Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4912-20 (2013)
Eth Zurich
The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 486-490 (2013)
Vanderbilt University
Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 441-445 (2013)
University of Southern Denmark
2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 589-602 (2013)
Seoul National University
Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 562-78 (2013)
Westf£Lische Wilhelms-Universit£T M£Nster
New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 924-34 (2013)
B.V. Patel Pharmaceutical Education and Research Development
Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 907-23 (2013)
University College London
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 540-53 (2013)
China Pharmaceutical University
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 512-28 (2013)
Universit£
Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4342-50 (2013)
Research Foundation Itsuu Laboratory
Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4420-5 (2013)
The University of Queensland
Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4396-404 (2013)
University of Maryland
Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3790-4 (2013)
Superacid Group In Organic Synthesis Team-Universit£
Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3818-21 (2013)
University of California
Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3884-6 (2013)
Kumamoto University
Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: role of the chirality on the biological activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3780-9 (2013)
Universit£
Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4301-10 (2013)
Xiangtan University
20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4279-87 (2013)
Chinese Academy of Sciences
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3914-9 (2013)
Bristol-Myers Squibb Research and Development
Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3983-7 (2013)
Jeil Pharmaceutical
Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3910-3 (2013)
Johns Hopkins University
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1488-96 (2013)
University of Oxford
A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 4: 847-851 (2013)
Virginia Commonwealth University
Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class ofs1 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 488-97 (2013)
Nstri
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3695-701 (2013)
Universit£
Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4798-810 (2013)
University of Bonn
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6279-96 (2013)
Universit£
X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4758-63 (2013)
The Pennsylvania State University
Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5094-114 (2013)
Glaxosmithkline
Identification of M. tuberculosis thioredoxin reductase inhibitors based on high-throughput docking using constraints.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4849-59 (2013)
Msd Animal Health Innovation
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4671-90 (2013)
Huazhong University of Science and Technology
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4442-55 (2013)
Eli Lilly
Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for ?-amyloid plaques.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3708-14 (2013)
Beijing Normal University
Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3723-9 (2013)
Nanjing University
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3967-75 (2013)
Boehringer Ingelheim (Canada)
Contributions of academic laboratories to the discovery and development of chemical biology tools.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 7161-76 (2013)
University of Pittsburgh
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 57: 1902-13 (2014)
Glaxosmithkline
Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 57: 1753-69 (2014)
Array Biopharma
Fragment-based ligand design of novel potent inhibitors of tankyrases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4497-508 (2013)
Nanyang Technological University
Discovery of the first histone deacetylase 6/8 dual inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4816-20 (2013)
Broad Institute of Mit and Harvard
New azole antagonists with high affinity for the P2Y(1) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3519-22 (2013)
Bristol-Myers Squibb
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3531-8 (2013)
Genentech
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4521-36 (2013)
Genentech
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4738-48 (2013)
China Pharmaceutical University
Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4264-76 (2013)
Boehringer Ingelheim Rcv
Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4028-43 (2013)
Brandeis University
Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3831-8 (2013)
Kumamoto University
Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 401-9 (2013)
Capital Normal University
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3565-9 (2013)
Roche Palo Alto
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3584-8 (2013)
Glaxosmithkline
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3561-4 (2013)
The University of Oklahoma Health Sciences Center
Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3662-6 (2013)
Takeda California
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3551-5 (2013)
University of Leeds
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3496-9 (2013)
East China University of Science and Technology
Caffeic acid derivatives: a new type of influenza neuraminidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3556-60 (2013)
Shandong University
Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3873-81 (2013)
Astellas Pharma
Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3523-30 (2013)
Xuzhou Medical College
In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 317-25 (2013)
Universidad De Santiago De Chile
Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 408-19 (2014)
Nycomed
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): aß-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4597-610 (2013)
Genentech
Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4300-19 (2013)
Peking University
Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 18260-70 (2013)
Uppsala University
Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4045-50 (2013)
Southwest University
Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3650-3 (2013)
Merck
Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3500-4 (2013)
Astrazeneca
Study of binding thermodynamics in the optimization of BH3 mimetics.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 394-400 (2013)
Dalian University of Technology
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 824-8 (2013)
The University of Mississippi
Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 817-23 (2013)
University of California-San Diego
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4764-85 (2013)
Genentech
Discovery of potent, selective chymase inhibitors via fragment linking strategies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4465-81 (2013)
Boehringer Ingelheim Pharmaceuticals
Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3959-68 (2013)
Yale University
1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptora.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4631-40 (2013)
Chinese Academy of Sciences
Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4509-20 (2013)
Westf£Lische Wilhelms-Universit£T M£Nster
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4701-17 (2013)
Istituto Italiano Di Tecnologia
X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4413-21 (2013)
University of Oxford
Optimized method of G-protein-coupled receptor homology modeling: its application to the discovery of novel CXCR7 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4236-51 (2013)
Pharmadesign
Optimized chemical probes for REV-ERBa.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4729-37 (2013)
Glaxosmithkline
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3640-5 (2013)
Merck Research Laboratories
Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3934-48 (2013)
Astellas Pharmaceutical
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4568-79 (2013)
Pfizer
Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4786-97 (2013)
Northwestern University
Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4277-99 (2013)
Universit£
Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4402-12 (2013)
The Ohio State University
A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3969-79 (2013)
University of Michigan
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3620-6 (2013)
Sanofi
Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3609-13 (2013)
Amgen
Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3730-7 (2013)
Korea Research Institute of Bioscience and Biotechnology
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4011-9 (2013)
Biogen Idec
Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4691-700 (2013)
Universit£
Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3922-35 (2013)
Max Institute of Psychiatry
Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 302-13 (2013)
University of Ljubljana
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 273-84 (2013)
Congenia
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 252-9 (2013)
University of Zanjan
Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 137-47 (2013)
University of Auckland
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 129-36 (2013)
Chinese Academy of Sciences
Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 62-73 (2013)
Shenyang Pharmaceutical University
Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3821-30 (2013)
Seoul National University
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3592-8 (2013)
Argenta Discovery
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3654-61 (2013)
University of Kansas Specialized Chemistry Center
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 1054-1058 (2012)
TBA
Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 35-41 (2013)
Universidade Federal De Santa Catarina
Development of peptidomimetic boronates as proteasome inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 64: 23-34 (2013)
Universit£
Synthesis of proline analogues as potent and selective cathepsin S inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3140-4 (2013)
Hanmi Research Center
NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3162-5 (2013)
China Pharmaceutical University
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3248-52 (2013)
Vanderbilt University Medical Center
Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3200-3 (2013)
Central South University
Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3257-61 (2013)
University of British Columbia
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4343-56 (2013)
Shionogi
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3996-4016 (2013)
Johns Hopkins University School of Medicine
Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2960-7 (2013)
Nankai University
Discovery of potent transient receptor potential vanilloid 1 antagonists: design and synthesis of phenoxyacetamide derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3154-6 (2013)
Toray Industries
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3157-61 (2013)
Bristol-Myers Squibb R & D
Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3710-24 (2013)
Sunovion Pharmaceuticals
Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4537-50 (2013)
The University of Kansas
Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4357-73 (2013)
Florida State University
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4580-96 (2013)
University of Bonn
Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5436-45 (2013)
National Cancer Institute
Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2843-55 (2013)
Shenyang Pharmaceutical University
Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3175-9 (2013)
Astrazeneca
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3186-94 (2013)
Genentech
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4422-41 (2013)
Duquesne University
Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5351-81 (2014)
Emory University
CROSS: an efficient workflow for reaction-driven rescaffolding and side-chain optimization using robust chemical reactions and available reagents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4656-70 (2013)
Sanofi-Aventis Deutschland
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 6297-313 (2013)
University of Illinois At Chicago
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3032-50 (2013)
Kitasato University
Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3164-74 (2013)
Wayne State University
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2975-87 (2013)
The City University of New York
Synthetic approaches to the 2011 new drugs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2795-825 (2013)
Shenogen Pharma Group
7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2868-78 (2013)
Dainippon Sumitomo Pharma
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3149-53 (2013)
Genentech
Effect of anchoring 4-anilidopiperidines to opioid peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3434-7 (2013)
University of Arizona
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3253-6 (2013)
Merck Research Laboratories
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3308-13 (2013)
Astraea Therapeutics
Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3214-20 (2013)
Kitasato University
Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3154-63 (2013)
Shionogi
Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3245-55 (2013)
Central China Normal University
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2925-31 (2013)
Atat£Rk University
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3358-63 (2013)
Pfizer
Dual-acting histone deacetylase-topoisomerase I inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3283-7 (2013)
Georgia Institute of Technology
Novel adamantyl cannabinoids as CB1 receptor probes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3904-21 (2013)
Northeastern University
Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3298-309 (2013)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse and Alcoholism
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2856-67 (2013)
National Health Research Institutes
Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2988-98 (2013)
Washington University
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4921-37 (2013)
Forma Therapeutics
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 15813-20 (2013)
The Ohio State University
Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4071-81 (2013)
University of Copenhagen
Synthesis and in vitro and in vivo characterization of highlyß1-selectiveß-adrenoceptor partial agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3852-65 (2013)
University of Nottingham
Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1435-41 (2013)
Beckman Research Institute of The City of Hope
Structure-based fragment screening is demonstrated to be a practical lead discovery method for a representative G-protein-coupled receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3444-5 (2013)
Pfizer
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3518-30 (2013)
Fondazione Istituto Italiano Di Tecnologia
The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3231-9 (2013)
Novartis Institutes For Biomedical Research
The systematic structure-activity relationship to predict how flavones bind to human androgen receptor for their antagonistic activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2968-74 (2013)
Meijo University
Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4803-12 (2013)
Universit£
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3889-903 (2013)
National Health Research Institutes
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5637-58 (2014)
Universit£
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 423-427 (2013)
Prenylx Research Institute
Discovery of natural estrogen receptor modulators with structure-based virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3329-33 (2013)
East China University of Science and Technology
Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3320-4 (2013)
Cha University
Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 254-258 (2013)
University of Minnesota
3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 57-62 (2012)
The University of Kansas
Structure-guided design of a selective BCL-X(L) inhibitor.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Nat Chem Biol 9: 390-7 (2013)
Walter and Eliza Hall Institute of Medical Research
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 854-68 (2013)
Quaid-I-Azam University
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3202-13 (2013)
University of Bern
Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3090-104 (2013)
Chinese Academy of Sciences
The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3240-4 (2013)
East China Normal University
Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3022-31 (2013)
Universiti Sains Malaysia
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3411-5 (2013)
Ucl School of Pharmacy
Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3230-4 (2013)
University of Rhode Island
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3239-43 (2013)
Bristol-Myers Squibb
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3427-33 (2013)
Monash University (Parkville Campus)
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3325-8 (2013)
Daiichi Sankyo
Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3300-3 (2013)
Institute of Chemical and Engineering Sciences
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3262-6 (2013)
Merck Research Laboratories
Synthesis and biological evaluation of Esaprazole analogues showings1 binding and neuroprotective properties in vitro.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3334-47 (2013)
Nensius Research
Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3356-62 (2013)
Kyoto University
Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3389-92 (2013)
Harvard Medical School
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3349-53 (2013)
RhôNe-Poulenc Rorer
Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3467-9 (2013)
Korea Institute of Science and Technology
Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3295-9 (2013)
Chinese Academy of Sciences
Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4082-92 (2013)
Xavier University of Louisiana
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3768-82 (2013)
H. Lee Moffitt Cancer Center and Research Institute
Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3531-45 (2013)
Korea Institute of Science and Technology (Kaist)
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3363-78 (2013)
Ludwig-Maximilians-University Munich
Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3262-71 (2013)
St. John'S University
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3175-96 (2013)
Daiichi Sankyo
Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3342-5 (2013)
University of Arkansas For Medical Sciences
1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3338-41 (2013)
San Francisco State University
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3443-7 (2013)
Pfizer
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Biochemistry 52: 2955-66 (2013)
Indiana University School of Medicine
Rational design and binding mode duality of MDM2-p53 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4053-70 (2013)
Amgen
Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3749-67 (2013)
National Institute of Diabetes and Digestive and Kidney Diseases
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3467-77 (2013)
Tufts University Sackler School of Biomedical Sciences
Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1423-8 (2013)
Chinese Academy of Sciences
Evaluating the Role of Macrocycles in the Susceptibility of Hepatitis C Virus NS3/4A Protease Inhibitors to Drug Resistance.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1469-78 (2013)
University of Massachusetts Medical School
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3421-6 (2013)
Sanofi Us
A cyclodextrin-capped histone deacetylase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3346-8 (2013)
University of Sussex
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3416-20 (2013)
Sanofi Us
ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3980-95 (2013)
F. Hoffmann-La Roche
Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2863-7 (2013)
Merck Research Laboratories
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2860-2 (2013)
University of Mississippi
A small molecule inhibitor of fungal histone acetyltransferase Rtt109.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2853-9 (2013)
University of Massachusetts Medical School
Recent advances in malaria drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2829-43 (2013)
Drug Discovery For Tropical Diseases
Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3742-6 (2013)
Ecole Polytechnique F�D�Rale De Lausanne Epfl
Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3733-41 (2013)
University of California
Thiophene-core estrogen receptor ligands having superagonist activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3346-66 (2013)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Synthesis and ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 4: 443-449 (2013)
Washington University School of Medicine
Inhibition of Ras-Effector Interaction by Cyclic Peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 4: 378-382 (2013)
The Ohio State University
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 640-644 (2012)
TBA
Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 811-25 (2013)
Research Foundation Itsuu Laboratory
Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 793-9 (2013)
Nmims University
Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 765-81 (2013)
Universit£
Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 758-64 (2013)
Ludwig-Maximilians-Universit£T M£Nchen
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3396-400 (2013)
Boehringer Ingelheim (Canada)
Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2880-2 (2013)
Ramkhamhaeng University
Discovery of novel orally bioavailable GPR40 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2920-4 (2013)
Shanghai Hengrui Pharmaceutical
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2764-71 (2013)
Institute of Organic Synthesis
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2695-702 (2013)
Kyoto University
Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2936-40 (2013)
Hoffmann-La Roche
Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2876-9 (2013)
Nanjing University
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3438-42 (2013)
Pfizer
Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 125-30 (2013)
Shandong University
Synthesis, evaluation and molecular docking of prolyl-fluoropyrrolidine derivatives as dipeptidyl peptidase IV inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 156-66 (2013)
Delhi Institute of Pharmaceutical Sciences and Research
In vitro evaluation of selected benzimidazole derivatives as an antioxidant and xanthine oxidase inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 290-5 (2013)
Konkuk University
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3943-58 (2013)
Universit£
5-Oxo-ETE receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3725-32 (2013)
Florida Institute of Technology
New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3330-8 (2013)
University of Athens
Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2948-50 (2013)
Bristol-Myers Squibb Research and Development
Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 338-43 (2014)
Nas of Ukraine
Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2897-901 (2013)
Chinese Academy of Sciences
Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 81: 695-706 (2013)
University of Troms£
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3609-19 (2013)
University of Copenhagen
Screening and structural analysis of flavones inhibiting tankyrases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3507-17 (2013)
University of Oulu
Structure-based identification of OATP1B1/3 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Mol Pharmacol 83: 1257-67 (2013)
Ku Leuven
SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3081-7 (2013)
Emd-Serono Research Institute
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3075-80 (2013)
Elan Pharmaceuticals
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2979-83 (2013)
Universiti Sains Malaysia
Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3568-81 (2013)
The Scripps Research Institute
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3645-55 (2013)
National Taiwan University
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3666-79 (2013)
Sirtris A Gsk
Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 685-95 (2013)
Jishou University
Direct targeting ofß-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4020-6 (2013)
Chemical Genomics Centre of The Max Planck Society
Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2772-7 (2013)
Bahirji Smarak Mahavidyalaya
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2955-61 (2013)
Pfizer
Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3034-8 (2013)
Penn State University College of Medicine
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3059-63 (2013)
Pfizer
Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 5219-30 (2014)
The University of Arizona
Determination of the ?-conotoxin Vc1.1 binding site on the ?9?10 nicotinic acetylcholine receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3557-67 (2013)
The University of Queensland
4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3582-92 (2013)
Astellas Pharma
Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3478-91 (2013)
Key Laboratory of Radiopharmaceuticals Beijing Normal University
The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 283-287 (2013)
The Scripps Research Institute
Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2968-73 (2013)
National Institute of Biology
Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3105-10 (2013)
Astrazeneca
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3039-43 (2013)
The State University of New Jersey
Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2962-7 (2013)
Mahidol University
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3051-8 (2013)
Pfizer
Arylsulfonamide pyrimidines as VLA-4 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 3070-4 (2013)
Elan Pharmaceuticals
Discovery of ML326: The first sub-micromolar, selective M5 PAM.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2996-3000 (2013)
Vanderbilt University Medical Center
Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2984-9 (2013)
Banaras Hindu University
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2912-5 (2013)
Shionogi
Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2687-94 (2013)
University of Chile
Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selectives1 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3656-65 (2013)
Esteve
A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2663-70 (2013)
Griffin Discoveries
Cytotoxic, antitopoisomerase II?, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 530-7 (2013)
Mahidol University
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3456-66 (2013)
Emory University
Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 14256-63 (2013)
University of Washington
Neoclerodanes as atypical opioid receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3435-43 (2013)
University of Kansas
Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 679-84 (2013)
The University of Mississippi
Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1291-302 (2013)
Massachusetts Institute of Technology
Structural basis for inhibition of the fat mass and obesity associated protein (FTO).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3680-8 (2013)
University of Oxford
Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3689-700 (2013)
Hokkaido University
Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3783-805 (2013)
Moffitt Cancer Center
3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3492-506 (2013)
Georgia Institute of Technology
Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3419-23 (2013)
Universit£
(3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained d-deoxyaltronojirimycin, from l-arabinose.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4813-9 (2013)
University of Oxford
Virtual medicinal chemistry: in silico pre-docking functional group transformation for discovery of novel inhibitors of botulinum toxin serotype A light chain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2505-11 (2013)
Panthera Biopharma
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2585-9 (2013)
Boehringer Ingelheim (Canada)
Hepatitis C replication inhibitors that target the viral NS4B protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 57: 2107-20 (2014)
Glaxosmithkline
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 578-88 (2013)
Neurosearch Sweden
Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2462-70 (2013)
China Pharmaceutical University
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2568-76 (2013)
Institute of Science and Technology
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2503-10 (2013)
The City University of New York
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2522-6 (2013)
Hoffmann-La Roche
Identification and design of a novel series of MGAT2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2721-6 (2013)
Astrazeneca
Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2480-5 (2013)
Sanofi
C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2696-703 (2013)
Yerevan State University
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2478-94 (2013)
Astellas Pharma
Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3367-78 (2013)
University Paris 6
Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3593-608 (2013)
Peking University
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3000-11 (2013)
Georgetown University Medical Center
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2793-800 (2013)
F. Hoffmann-La Roche
Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2614-8 (2013)
University of Massachusetts Boston
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinaseß isoform.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2606-13 (2013)
Genentech
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2801-7 (2013)
Baylor University
Design, synthesis and biological activities of Nilotinib derivates as antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2527-34 (2013)
Xi'An Jiaotong University
Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 558-69 (2013)
Korea Institute of Science and Technology
Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3379-403 (2013)
Array Biopharma
Investigation of the role of linker moieties in bifunctional tacrine hybrids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 3614-23 (2013)
University of Michigan
Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2590-4 (2013)
Merck Research Laboratories
Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2653-8 (2013)
Rottapharm Madaus
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2659-62 (2013)
Kitasato University
Novel and highly potent histamine H3 receptor ligands. Part 3: an alcohol function to improve the pharmacokinetic profile.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2548-54 (2013)
Bioprojet-Biotech
Antileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 185-9 (2014)
Karunya University
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1044-52 (2013)
University of Dundee
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3191-206 (2013)
Universit£
Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 511-22 (2013)
North-West University
Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3833-51 (2013)
Chinese Academy of Sciences
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2948-58 (2013)
University of Alberta
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2579-84 (2013)
Aurigene Discovery Technologies
Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2512-7 (2013)
Shandong University
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2601-5 (2013)
King Saud University
A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2595-7 (2013)
Janssen Research and Development
Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2560-5 (2013)
Daiichi Sankyo
SAR based design of nicotinamides as a novel class of androgen receptor antagonists for prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3414-8 (2013)
Chonnam National University
Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3296-309 (2013)
Peking University
Exploring the effect of ![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 4: 564-568 (2013)
University of Arkansas For Medical Sciences
Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 98-102 (2013)
Universit£
Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 484-500 (2013)
Medical University of Warsaw
Design and synthesis of novel chromenone derivatives as interleukin-5 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2543-50 (2013)
Chungnam National University
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2651-62 (2013)
Walter Reed Army Institute of Research
In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2642-6 (2013)
Sungkyunkwan [Corrected] University
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2743-9 (2013)
Elan Pharmaceuticals
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2688-91 (2013)
Janssen Research & Development
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3310-7 (2013)
University of Nottingham
Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3273-80 (2013)
Astrazeneca
Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3429-33 (2013)
Vanderbilt University Institute of Imaging Science (Vuiis)
Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3281-95 (2013)
Chinese Academy of Sciences
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3424-8 (2013)
Universit£
Improving the affinity of SL0101 for RSK using structure-based design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 175-179 (2012)
Vanderbilt University
Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2683-7 (2013)
The Scripps Research Institute
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2434-50 (2013)
R.C. Patel Institute of Pharmaceutical Education and Research
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2551-9 (2013)
Medical University of South Carolina
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 57: 1790-801 (2014)
Uppsala University
Orally active opioid compounds from a non-poppy source.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4840-8 (2013)
Temple University
Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 489-94 (2013)
National Sun Yat-Sen University
Therapeutic agents triggering nonapoptotic cancer cell death.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4823-39 (2013)
Texas State University-San Marcos
Biophysical fragment screening of theß1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3446-55 (2013)
Heptares Therapeutics
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3217-27 (2013)
University of Oxford
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3177-90 (2013)
Astrazeneca
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 378-86 (2013)
National University of Singapore
Carbonic anhydrase inhibitors: inhibition of theß-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2647-52 (2013)
Universit£
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2636-41 (2013)
China Pharmaceutical University
Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2643-50 (2013)
Gwangju Institute of Science and Technology
Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2663-70 (2013)
Shandong University
Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3228-34 (2013)
Astrazeneca
Structure-based design of ?-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4156-80 (2013)
Vitae Pharmaceuticals
Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 4: 130-134 (2013)
The Johns Hopkins University School of Medicine
Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2635-42 (2013)
Helmholtz-Zentrum Dresden-Rossendorf
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2600-17 (2013)
Chinese Academy of Sciences
Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2787-92 (2013)
Pfizer
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors ?/? agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 321-32 (2013)
Universit£
Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 313-20 (2013)
University of M£Nster
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 299-312 (2013)
Sun Yat-Sen University
Novel IKKß inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 269-78 (2013)
China Pharmaceutical University
New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2455-9 (2013)
Galapagos
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2298-301 (2013)
Clermont Universit£
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2313-8 (2013)
Chinese Academy of Medical Sciences and Peking Union Medical College
Exploring the UDP pocket of LpxC through amino acid analogs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2362-7 (2013)
Astrazeneca
Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2623-34 (2013)
Korea Basic Science Institute
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2333-45 (2013)
Takeda Pharmaceutical
VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2241-9 (2013)
Reveragen Biopharma
Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2587-99 (2013)
St. Jude Children'S Research Hospital
Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2271-85 (2013)
Hanyang University
Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 1074-82 (2013)
Boehringer Ingelheim (Canada)
Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2286-97 (2013)
Nanjing University
Design and synthesis of a series of ?-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2319-2332 (2013)
Okayama University
Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at¿-aminobutyric acid type A (GABA(A)) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2186-98 (2013)
Sintesi E Studio Di Eterocicli Biologicamente Attivi (Heterobiolab) Universit£
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2314-8 (2013)
University of Florida
Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2250-61 (2013)
Takeda Pharmaceutical
Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2368-72 (2013)
Ge Healthcare
Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2380-3 (2013)
Shanxi Medical University
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2344-8 (2013)
Pfizer
Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAF(V600E) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2306-12 (2013)
Central South University
Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2422-5 (2013)
Universit£
Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2324-7 (2013)
Toronto General Research Institute
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2936-47 (2013)
Universit£
Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 281-91 (2014)
King Fahd University of Petroleum & Minerals
Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 292-6 (2014)
S.G.S.I.T.S.
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 303-10 (2014)
Tokushima Bunri University
Paclitaxel is an inhibitor and its boron dipyrromethene derivative is a fluorescent recognition agent for botulinum neurotoxin subtype A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2791-803 (2013)
Lakehead University and Thunder Bay Regional Research Institute
Progress and developments in tau aggregation inhibitors for Alzheimer disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4135-55 (2013)
Humboldt Universit£T Zu Berlin
N-substituted azaindoles as potent inhibitors of Cdc7 kinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2056-60 (2013)
Amgen
Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1993-6 (2013)
China Pharmaceutical University
Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1916-22 (2013)
Complutense University of Madrid
Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors ofß-secretase (BACE1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2396-412 (2013)
Tehran University of Medical Sciences
N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides as potent and selective ligands for A1 adenosine receptors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 22-38 (2013)
Universit£
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2432-5 (2013)
Bristol-Myers Squibb Pharmaceutical Research Institute
Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2414-21 (2013)
Sanofi R & D
Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2229-40 (2013)
Mcgill University
Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2217-28 (2013)
Bristol-Myers Squibb
Synthesis and evaluation of an imidazole derivative-fluorescein conjugate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2418-25 (2013)
University of Texas At Houston
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potentµ-opioid agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3102-14 (2013)
Lanzhou University
The development of highly potent inhibitors for porcupine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2700-4 (2013)
The University of Texas Southwestern Medical Center
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 151-61 (2013)
University of Santiago De Compostela
Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 118-32 (2013)
Sapienza University of Rome
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2391-4 (2013)
Cardiff University
Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2384-90 (2013)
Bayer Healthcare
Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2408-13 (2013)
Chinese Academy of Sciences
26- and 27-Methyl groups of 2-substituted, 19-nor-1a,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Bioorg Chem 47: 9-16 (2013)
University of Wisconsin-Madison
Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H-imidazole derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2355-62 (2013)
Tehran University of Medical Sciences
Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2413-7 (2013)
Kyoto University
BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2442-50 (2013)
The First People'S Hospital of Hangzhou
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3012-23 (2013)
Oslo University Hospital
Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2828-40 (2013)
Leiden University
Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3090-101 (2013)
Genentech
The impact of introducing a histidine into an apolar cavity site on docking and ligand recognition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2874-84 (2013)
University of California San Francisco
Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2885-903 (2013)
Chinese Academy of Sciences
Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2568-80 (2013)
Institutes For Pharmaceutical Discovery
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2581-605 (2013)
Purdue University
In search of new herbicidal inhibitors of the non-mevalonate pathway.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pest Manag Sci 69: 559-63 (2013)
Basf-Se
Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2447-55 (2013)
University of Catania
Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3068-77 (2013)
Washington University
Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2841-9 (2013)
National Taiwan University
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 95-103 (2013)
Chinese Academy of Sciences
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 85-94 (2013)
Universit£
Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2078-82 (2013)
East China University of Science and Technology
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2031-4 (2013)
Veterans Affairs Medical Center
A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues asa-glucosidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2022-6 (2013)
Xi'An Jiaotong University
Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2089-92 (2013)
China Pharmaceutical University
PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1961-6 (2013)
Pfizer
[11C]olanzapine, radiosynthesis and lipophilicity of a new potential PET 5-HT2 and D2 receptor radioligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1953-6 (2013)
Indiana University School of Medicine
Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2019-21 (2013)
University of Arkansas For Medical Sciences
Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1945-8 (2013)
Astrazeneca
Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1764-74 (2013)
University of Kentucky
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2181-6 (2013)
Elan Pharmaceuticals
New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2451-4 (2013)
Galapagos
Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2052-5 (2013)
Bristol-Myers Squibb Research and Development
Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 249-55 (2014)
Bc Cancer Agency
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1735-48 (2013)
University of Pardubice
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1643-51 (2013)
The University of Tokyo
Improvement ofs1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1844-56 (2013)
Wilhelms-Universit£T M£Nster
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1756-63 (2013)
Epichem
Microwave-assisted synthesis and tyrosinase inhibitory activity of chalcone derivatives.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 82: 39-47 (2013)
Shaoyang University
(+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 727-31 (2013)
Universit£
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3121-47 (2013)
Northwestern University
Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2676-89 (2013)
Universit£
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 64-75 (2013)
University of M£Nster
Fungal transformation of cedryl acetate anda-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 764-70 (2013)
University of Karachi
Structure-based drug design using GPCR homology modeling: toward the discovery of novel selective CysLT2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 754-63 (2013)
Zhejiang University
Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 33-45 (2013)
King Saud University
New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 63: 1-13 (2013)
Sun Yat-Sen University
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 745-53 (2013)
Sun Yat-Sen University
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 738-44 (2013)
University of Auckland
Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 728-37 (2013)
Universit£
Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 722-7 (2013)
Institut De Biologie Et De Technologies De Saclay (Ibitecs)
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1696-707 (2013)
Universiti Sains Malaysia
Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2370-2378 (2013)
Universidad De Alcala
Triazolopyridazine LRRK2 kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1967-73 (2013)
Elan Pharmaceuticals
Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2007-13 (2013)
University of Strasburg
Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2177-80 (2013)
Boehringer Ingelheim Pharmaceuticals
2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2027-30 (2013)
Institutes For Pharmaceutical Discovery
Synthesis and anti-acetylcholinesterase properties of novel ?- and ?-substituted alkoxy organophosphonates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2048-51 (2013)
The University of Montana
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1621-7 (2013)
Shandong University
A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2106-10 (2013)
Asahi Kasei Pharma
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2035-43 (2013)
University of Illinois At Chicago
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1974-7 (2013)
Elan Pharmaceuticals
On dihydroorotate dehydrogenases and their inhibitors and uses.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3148-67 (2013)
Institut Pasteur
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3024-32 (2013)
Northwestern University
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2415-28 (2013)
Virginia Commonwealth University
Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2779-90 (2013)
University of Kansas Medical Center
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3048-67 (2013)
University of Michigan
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2513-26 (2013)
The University of Queensland
Selective 3-phosphoinositide-dependent kinase 1 (PDK1) inhibitors: dissecting the function and pharmacology of PDK1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2726-37 (2013)
Glaxosmithkline
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2311-22 (2013)
University of Southern California
Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2695-9 (2013)
Vanderbilt University Medical Center
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2110-24 (2013)
University of North Carolina At Chapel Hill
A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2619-29 (2013)
Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3033-47 (2013)
Cyclofluidic
Orvinols with mixed kappa/mu opioid receptor agonist activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 3207-16 (2013)
University of Bath
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2651-64 (2013)
Universit£
Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2246-55 (2013)
Mayo Clinic
Colloidal aggregation causes inhibition of G protein-coupled receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2406-14 (2013)
University of North Carolina At Chapel Hill
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 649-60 (2013)
University of Toyama
Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 632-48 (2013)
Xiamen University
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 614-31 (2013)
Cairo University
Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2151-4 (2013)
Tohoku Pharmaceutical University
Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2197-201 (2013)
Montana State University
Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2212-6 (2013)
Actelion Pharmaceuticals
Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2225-9 (2013)
Fudan University
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2128-33 (2013)
Rensselaer Polytechnic Institute
A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2101-5 (2013)
Madurai Kamaraj University
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1724-34 (2013)
East China University of Science and Technology
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1857-64 (2013)
Duquesne University
Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1708-16 (2013)
Instituto De Qu£Mica M£Dica
Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1749-55 (2013)
Chinese Academy of Science
Semisynthetic studies identify mitochondria poisons from botanical dietary supplements--geranyloxycoumarins from Aegle marmelos.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1795-803 (2013)
University of Mississippi
Design, synthesis and SAR of novel glucokinase activators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2166-71 (2013)
Takeda California
Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2134-9 (2013)
Sk Biopharmaceuticals
Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1787-94 (2013)
Entremed
Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1880-97 (2013)
University of Michigan
Stereoselective synthesis of a new class of potent and selective inhibitors of human¿8,7-sterol isomerase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1925-43 (2013)
Ludwig-Maximilians University
Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 243-8 (2014)
Medical University
Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2747-63 (2013)
University of Florida
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2283-93 (2013)
Yokohama City University
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17ß-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2429-46 (2013)
Vanderbilt University School of Medicine
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 597-604 (2013)
East China University of Science and Technology
Discovery of dopamine D4 receptor antagonists with planar chirality.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1680-4 (2013)
Friedrich-Alexander University
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2135-44 (2013)
Universit£
Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2642-50 (2013)
Chinese Academy of Sciences
Evaluation of difluoromethyl ketones as agonists of the¿-aminobutyric acid type B (GABAB) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2456-65 (2013)
Purdue University
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2256-69 (2013)
Universit£
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2207-17 (2013)
Novartis Pharma
Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 556-63 (2013)
Universidade Federal Do Rio Grande Do Sul
Farnesyl diphosphate synthase inhibitors from in silico screening.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 81: 742-8 (2013)
University of California San Diego
Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1715-22 (2013)
University Health Network
Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 515-25 (2013)
Dongguk University-Seoul
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacyµ opioid receptor (MOR) agonist/d opioid receptor (DOR) antagonist ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2139-49 (2013)
University of Michigan
Incorporation of rapid thermodynamic data in fragment-based drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2155-9 (2013)
The University of Tokyo
3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1639-42 (2013)
Hanyang University
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1622-5 (2013)
Bristol-Myers Squibb Research and Development
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1604-7 (2013)
Bristol-Myers Squibb R & D
Amino acid derived quinazolines as Rock/PKA inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1592-9 (2013)
Translational Research Institute
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1860-4 (2013)
Vanderbilt University Medical Center
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2128-34 (2013)
Shandong University
Novel imidazophenoxazine-4-sulfonamides: their synthesis and evaluation as potential inhibitors of PDE4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1952-63 (2013)
Ckm Arts and Science College
Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1944-51 (2013)
Centro De Investigaci�N Pr�Ncipe Felipe
Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1964-71 (2013)
Rhodes University
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2018-24 (2013)
Kyung Hee University
Investigation ofs receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1865-9 (2013)
Universit£
Structure-based discovery of cellular-active allosteric inhibitors of FAK.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1779-85 (2013)
Takeda Pharmaceutical
Spirocyclic compounds, potent CCR1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1883-6 (2013)
Astrazeneca
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1891-5 (2013)
St. Jude Children'S Research Hospital
3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (s1) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1707-11 (2013)
Northeast Ohio Medical University
Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1684-8 (2013)
Bristol-Myers Squibb Pharmaceutical Research Institute
Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1743-7 (2013)
Bristol-Myers Squibb
Anion inhibition studies of thea-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1636-8 (2013)
Universit£
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1588-91 (2013)
Celgene
Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1748-51 (2013)
Korea Research Institute of Bioscience and Biotechnology
Kinetic and anion inhibition studies of aß-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1626-30 (2013)
Istituto Di Biostrutture E Bioimmagini
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1617-21 (2013)
Toray Industries
Vegfrecine, an inhibitor of VEGF receptor tyrosine kinases isolated from the culture broth of Streptomyces sp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 715-9 (2013)
Institute of Microbial Chemistry (Bikaken)
Psoralen derivatives as inhibitors of NF-¿B/DNA interaction: synthesis, molecular modeling, 3D-QSAR, and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1830-42 (2013)
Universit£
Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1614-28 (2013)
University of Copenhagen
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aß Reduction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 897-902 (2012)
TBA
Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2025-36 (2013)
Westf£Lische Wilhelms-Universit£T M£Nster
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2088-92 (2013)
Payame Noor University
Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1736-9 (2013)
Korea Research Institute of Chemical Technology
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 2234-7 (2013)
Janssen Research and Development
Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1776-8 (2013)
Ocean University of China
Flavonoids as receptor tyrosine kinase FLT3 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1768-70 (2013)
Dongguk University-Seoul
Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2'-quinazolines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1351-7 (2013)
University of Hyderabad Campus
Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1922-39 (2013)
The University of Arizona
Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2087-96 (2013)
Vu University Amsterdam
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1946-60 (2013)
Glaxosmithkline
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 198-204 (2014)
Universidad De La Republica
A nonionic inhibitor with high specificity for the UDP-Gal donor binding site of human blood group B galactosyltransferase: design, synthesis, and characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2150-4 (2013)
University of Hamburg
Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2045-58 (2013)
University of Pittsburgh
Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2117-27 (2013)
University of Louisiana At Monroe
Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-? aggregation inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1703-6 (2013)
Winthrop University
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1834-8 (2013)
Broad Institute of Mit and Harvard
Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1760-2 (2013)
Key Laboratory of Medicinal Chemistry For Natural Resource (Yunnan University)
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1870-3 (2013)
Bristol-Myers Squibb Research & Development
Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1631-5 (2013)
Universidade De Vigo
Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 215-22 (2014)
Msa University
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 958-65 (2013)
University of North Carolina At Chapel Hill
Synthesis and biological evaluation of guanidino analogues of roscovitine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 443-52 (2013)
Palack£
Design, Synthesis, Structural Characterization by IR, (1) H, (13) C, (15) N, 2D-NMR, X-Ray Diffraction and Evaluation of a New Class of Phenylaminoacetic Acid Benzylidene Hydrazines as pfENR Inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 81: 715-29 (2013)
Bombay College of Pharmacy
Mexican antidiabetic herbs: valuable sources of inhibitors ofa-glucosidases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 468-83 (2013)
Universidad Nacional Aut£Noma De M£Xico
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2160-4 (2013)
University of Copenhagen
Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1996-2015 (2013)
Astrazeneca
Design and optimization of selective protein kinase C¿ (PKC¿) inhibitors for the treatment of autoimmune diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1799-810 (2013)
Vertex Pharmaceuticals
?-(Substituted-phenoxyacetoxy)-?-heterocyclylmethylphosphonates: synthesis, herbicidal activity, inhibition on pyruvate dehydrogenase complex (PDHc), and application as postemergent herbicide against broadleaf weeds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Agric Food Chem 61: 2479-88 (2013)
Central China Normal University
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 994-1003 (2013)
Dalian Medical University
In vitro activity of scorpiand-like azamacrocycle derivatives in promastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 466-77 (2013)
Universidad De Granada
Characterization of a selective CaMKII peptide inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 425-34 (2013)
University of Naples Federico Ii
Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1865-9 (2013)
The University of Utah
Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1789-92 (2013)
University of Debrecen
Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1817-22 (2013)
Sanofi-Aventis Deutschland
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1887-90 (2013)
Korea Institute of Science and Technology
Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1662-6 (2013)
Okayama University 1-1-1
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1544-7 (2013)
University of Illinois At Chicago
Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1972-7 (2013)
St. Jude Children'S Research Hospital
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2045-55 (2013)
Shionogi
Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic--targeting Mycobacterium tuberculosis ribonucleotide reductase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1992-2000 (2013)
Uppsala University
Novel symmetrical ureas as modulators of protein arginine methyl transferases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2056-67 (2013)
Universidade De Vigo
Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1379-85 (2013)
Atat£Rk University
Synthesis and biological evaluation of substituted imidazoquinoline derivatives as mPGES-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2068-78 (2013)
Dainippon Sumitomo Pharma
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2093-106 (2013)
Vilnius University Institute of Biotechnology
Antidepressant abietane diterpenoids from Chinese eaglewood.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 216-22 (2013)
Chinese Academy of Medical Sciences and Peking Union Medical College
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2059-73 (2013)
Astrazeneca
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2125-38 (2013)
Astrazeneca
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1878-93 (2013)
The Beatson Institute For Cancer Research
1,2,3,4,6-Penta-O-galloyl-?-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1940-5 (2013)
Harvard Medical School
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2218-34 (2013)
Exelixis
Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1182-6 (2013)
Birla Institute of Technology
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 2156-62 (2013)
Sun Yat-Sen University
Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1050-63 (2013)
Nanjing University
Cloning, characterization, and sulfonamide and thiol inhibition studies of ana-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1761-71 (2013)
University of Tampere and Tampere University Hospital
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1894-907 (2013)
Kitasato University
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1865-77 (2013)
Okayama University Graduate School of Medicine
Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 168-74 (2014)
Atatürk University
Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 916-22 (2013)
Gilead Sciences
Sesquiterpenes from the rhizomes of Curcuma heyneana.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 223-9 (2013)
University of Toyama
Reversible inhibition of human carboxylesterases by acyl glucuronides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 698-703 (2013)
Eisai
Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1193-6 (2013)
Korea Institute Science and Technology
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1220-4 (2013)
Trinity College
Novel acylethanolamide derivatives that modulate body weight through enhancement of hypothalamic pro-opiomelanocortin (POMC) and/or decreased neuropeptide Y (NPY).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1811-29 (2013)
Hebrew University of Jerusalem
Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1064-73 (2013)
Hainan University
Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1177-81 (2013)
F. Hoffmann-La Roche
Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1477-81 (2013)
University of Freiburg
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1257-61 (2013)
Amri
Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 395-404 (2013)
Dr. Reddy'S Laboratories
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2294-310 (2013)
Merck
Torsion angle preferences in druglike chemical space: a comprehensive guide.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2016-28 (2013)
University of Hamburg
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1693-703 (2013)
University of Arkansas For Medical Sciences
Absorption, elimination, and metabolism of CS-1036, a novela-amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 878-87 (2013)
Daiichi Sankyo
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 379-94 (2013)
Universit£
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 352-70 (2013)
University of Patras
Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 329-40 (2013)
University of Ljubljana
Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 311-9 (2013)
University of Life Sciences
Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 301-10 (2013)
Fudan University
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1284-304 (2013)
The Institute of Cancer Research
Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1206-11 (2013)
Nanjing University of Chinese Medicine
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1212-6 (2013)
Astrazeneca
Critical role of a methyl group on the¿-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1217-9 (2013)
Kyoto Pharmaceutical University
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1279-84 (2013)
University of Connecticut
Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dualß2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1548-52 (2013)
Sun Yat-Sen University
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1109-15 (2013)
The University of Tokyo
The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3a-acyloxy-6ß-acetoxyltropane derivatives as muscarinic M3 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1234-9 (2013)
Shanghai Jiao Tong University
Selective inhibition of glycosyltransferases by bivalent imidazolium salts.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1305-11 (2013)
Queen'S University
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1312-23 (2013)
Duquesne University
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1370-4 (2013)
Universit£
Inhibition of monoamine oxidase by phthalide analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1269-73 (2013)
North-West University
1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1228-31 (2013)
Chemocentryx
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1249-52 (2013)
Eli Lilly
Inhibiting NF-¿B-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1238-44 (2013)
Amgen
Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1519-21 (2013)
College of Pharmacy of Kangwon National University
Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1843-52 (2013)
University of Leeds
Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 870-7 (2013)
University of Arkansas For Medical Sciences
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 858-69 (2013)
University of Michigan Medical School
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1285-7 (2013)
Kitasato University
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 767-77 (2013)
National Cancer Institute-Bethesda
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1704-14 (2013)
Bristol-Myers Squibb Research and Development
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1772-6 (2013)
Broad Institute of Mit and Harvard
The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Biochemistry 52: 1776-1787 (2013)
University of Auckland
Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 796-803 (2013)
University of Kentucky
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1723-9 (2013)
University of Bologna
Pharmacological chaperones as therapeutics for lysosomal storage diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2705-25 (2013)
Amicus Therapeutics
Development of inhibitors of the PAS-B domain of the HIF-2a transcription factor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1739-47 (2013)
University of Texas Southwestern Medical Center
Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1641-55 (2013)
Sichuan University
Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1748-60 (2013)
Trius Therapeutics
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypesa5ß1 andavß6: conformational control through flanking amino acids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1509-19 (2013)
Technische Universit£T M£Nchen
A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1583-95 (2013)
Universit£
Development of¿ opioid receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2178-95 (2013)
Research Triangle Institute
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Ka.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 712-21 (2013)
Celgene Avilomics Research
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2196-206 (2013)
Novartis Pharma
Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2165-77 (2013)
University of Toronto Mississauga
Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1334-7 (2013)
Chinese Academy of Sciences
Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1398-406 (2013)
Lundbeck Research Usa
Phosphonic analogues of glutamic acid as irreversible inhibitors of Staphylococcus aureus endoproteinase GluC: an efficient synthesis and inhibition of the human IgG degradation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1412-5 (2013)
Wroclaw University of Technology
Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 256-69 (2013)
Neuroscienze Pharmaness S.C.A R.L.
N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1150-8 (2013)
Volgograd State Medical University
Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1349-56 (2013)
Kangwon National University
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1777-81 (2013)
Goethe-University Frankfurt
Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 132-6 (2014)
Sakarya University
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 124-31 (2014)
Vilnius University
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 814-26 (2013)
Glaxosmithkline
Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 479-89 (2013)
Universitat De Barcelona
Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 241-55 (2013)
Neurosearch Sweden
2,3-diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17ß-hydroxysteroid dehydrogenase (AKR1C3).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 89-97 (2013)
University of Ljubljana
Design, synthesis and SAR of piperidyl-oxadiazoles as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 1-10 (2013)
Chinese Academy of Sciences
Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 222-31 (2013)
Hefei University of Technology
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 214-21 (2013)
Universidade Federal De Goi£S
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 62: 148-57 (2013)
Second Military Medical University
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1333-43 (2013)
University of California
o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1386-91 (2013)
Istanbul University
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1486-92 (2013)
Roche Palo Alto
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the ?3?4 nicotinic acetylcholine receptor (nAChR).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1450-5 (2013)
Targacept
Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1257-67 (2013)
Dainippon Sumitomo Pharma
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1677-92 (2013)
Hoffmann-La Roche
Docking-based virtual screening of covalently binding ligands: an orthogonal lead discovery approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1478-90 (2013)
Msd Animal Health Innovation
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1098-112 (2013)
Universit£
Synthesis, fungicidal activity, and sterol 14?-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Agric Food Chem 61: 1419-26 (2013)
Central China Normal University
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1276-90 (2013)
University of Florida
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1324-32 (2013)
Universit£
A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1456-61 (2013)
Theravance
Using a fragment-based approach to target protein-protein interactions.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chembiochem 14: 332-42 (2013)
University of Cambridge
Organic anion transporter 3 interacts selectively with lipophilicß-lactam antibiotics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 791-800 (2013)
Wilkes University
Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of A? plaques.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 469-78 (2013)
Nagasaki University
Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1149-59 (2013)
Cea
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2738-46 (2013)
Rutgers University
Effect of helical conformation and side chain structure on ?-secretase inhibition by ?-peptide foldamers: insight into substrate recognition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1443-54 (2013)
Nagoya City University
Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 715-720 (2012)
TBA
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1344-8 (2013)
The Scripps Research Institute
Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 735-47 (2013)
Ikerchem
In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 118-23 (2014)
Sakarya University
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1159-65 (2013)
Toho University
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1219-33 (2013)
Astellas Pharma
Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1407-11 (2013)
Pfizer
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1433-7 (2013)
Guru Nanak Dev University
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward¿-aminobutyric acid transporter 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1323-40 (2013)
Ludwig Maximilians University At Munich
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 4: 22-26 (2013)
University of Athens
Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1553-6 (2013)
Activx Biosciences
Design and synthesis of D1 agonist/D2 antagonist for treatment of schizophrenia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1498-501 (2013)
Sanofi Us
Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1472-6 (2013)
Brain Science Institute
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 891-902 (2013)
Duquesne University
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 856-68 (2013)
Chinese Academy of Sciences
Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 671-84 (2013)
Chinese Academy of Sciences
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 2038-44 (2013)
Universidade Federal De S£O Carlos
Selective inhibition of extracellular thioredoxin by asymmetric disulfides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1301-10 (2013)
Stanford University
Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Seoul National University
Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates().![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 3: 65-67 (2012)
The Johns Hopkins University School of Medicine
Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1004-7 (2013)
Brandeis University
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 944-8 (2013)
Actelion Pharmaceuticals
Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 18-22 (2014)
Sakarya University
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 59-63 (2014)
Gyeongsang National University
Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1573-82 (2013)
University of South Carolina
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1262-75 (2013)
Leiden Institute of Chemistry and Netherlands Proteomics Centre
Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1171-81 (2013)
University of Copenhagen
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 441-50 (2013)
Chinese Academy of Sciences
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 431-40 (2013)
Universidad De Buenos Aires
Radiolytic transformation of rotenone with potential anti-adipogenic activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1099-103 (2013)
Korea Atomic Energy Research Institute
A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 939-43 (2013)
Theravance
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 985-8 (2013)
Merck Research Laboratories
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 979-84 (2013)
Osi Pharmaceuticals
Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1341-5 (2013)
Amgen
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 867-78 (2013)
Virginia Commonwealth University
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 761-80 (2013)
Chinese Academy of Sciences
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 410-20 (2013)
Dalian University of Technology
Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 333-9 (2013)
Kyushu Institute of Technology
Inhibition of protein glycation by urea and thiourea derivatives of glycine/proline conjugated benzisoxazole analogue - synthesis and structure-activity studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 325-32 (2013)
University of Mysore
Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 295-304 (2013)
Tohoku Pharmaceutical University
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 285-94 (2013)
Columbia University
Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1070-4 (2013)
Janssen Research and Development
Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1091-5 (2013)
Nanjing University
Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1482-5 (2013)
Ranbaxy Research Laboratories
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 996-1000 (2013)
Elan Pharmaceuticals
Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1051-5 (2013)
Pfizer
Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: some structural aspects for aldose reductase inhibitory activity and selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 869-73 (2013)
Aristotle University of Thessaloniki
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 874-82 (2013)
Humboldt Universit£T Zu Berlin
Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4-beta1 and alpha4-beta7 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1026-31 (2013)
Hoffmann-La Roche
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1046-50 (2013)
Pfizer
Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual actinga4ß1 anda4ß7 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1036-40 (2013)
Hoffmann-La Roche
A comparative protease stability study of synthetic macrocyclic peptides that mimic two endocrine hormones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 989-95 (2013)
The College of New Jersey
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 81: 607-14 (2013)
Umdnj-New Jersey Medical School
Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 29: 35-42 (2014)
Atatürk University
The 2.5Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 963-9 (2013)
Eli Lilly
Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 1: 433-438 (2010)
TBA
Thiolactomycin-based ß-Ketoacyl-AcpM Synthase A (KasA) Inhibitors: FRAGMENT-BASED INHIBITOR DISCOVERY USING TRANSIENT ONE-DIMENSIONAL NUCLEAR OVERHAUSER EFFECT NMR SPECTROSCOPY.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 6045-52 (2013)
Institute For Chemical Biology & Drug Discovery
Probing the steric requirements of the¿-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 903-11 (2013)
Northwestern University
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 957-63 (2013)
University of Southern California
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1132-5 (2013)
Drexel University College of Medicine
Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1136-42 (2013)
Seoul National University
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 714-26 (2013)
Eli Lilly
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 832-42 (2013)
Indiana University School of Medicine
A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 691-9 (2013)
University of Washington
Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1023-40 (2013)
Ariad Pharmaceuticals
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 382-7 (2013)
University of North Carolina At Greensboro
Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 640-59 (2013)
University of Nottingham
Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 879-94 (2013)
Chinese Academy of Sciences
Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1136-48 (2013)
University of British Columbia
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1211-27 (2013)
University of Copenhagen
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1120-6 (2013)
Pfizer
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1228-46 (2013)
Takeda Pharmaceutical
Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1074-83 (2013)
Georgia State University
Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 979-92 (2013)
Amgen
Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 948-56 (2013)
Universit£
Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 993-1005 (2013)
The University of Tokyo
Further characterization of a putative serine protease contributing to the¿-secretase cleavage ofß-amyloid precursor protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1018-29 (2013)
University of Montpellier
Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-ß type 1 receptor kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1083-6 (2013)
Ewha Womans University
A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1063-9 (2013)
Janssen Research and Development
Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1104-9 (2013)
University of Hyderabad Campus
Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1160-70 (2013)
Merck Serono
Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 982-92 (2013)
University of Southern Denmark
Development of new cyclic plasmin inhibitors with excellent potency and selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 820-31 (2013)
Philipps University Marburg
Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1389-404 (2013)
University of Nottingham
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as¿-aminobutyric acid(a) receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 993-1006 (2013)
University of Copenhagen
Polyamine-based small molecule epigenetic modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 3: 14-21 (2012)
Wayne State University
Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 187-98 (2013)
Cairo University
Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1396-403 (2013)
Salman Bin Abdulaziz University
Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 582-91 (2013)
University of Helsinki
SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 614-9 (2013)
The Scripps Research Institute
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 120-7 (2013)
Csir-Central Drug Research Institute
An unprecedented reversible mode of action ofß-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 101-11 (2013)
Universit£
Sulphonamides: Deserving class as MMP inhibitors?![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 89-100 (2013)
Indian Institute of Technology (Bhu)
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 952-62 (2013)
University of Texas Medical Branch
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1535-43 (2013)
Helmholtz Centre For Infection Research
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 36-44 (2013)
St. Jude Children'S Research Hospital
Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1064-73 (2013)
University of Eastern Finland
Amide hydrolysis of a novel chemical series of microsomal prostaglandin E synthase-1 inhibitors induces kidney toxicity in the rat.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 634-41 (2013)
Astrazeneca
Systematic exploration of dual-acting modulators from a combined medicinal chemistry and biology perspective.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1197-210 (2013)
Astrazeneca
Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1350-4 (2013)
Utrecht University
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1247-61 (2013)
Universit£
Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 460-70 (2013)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 42-50 (2013)
Jagiellonian University Medical College
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 29-41 (2013)
National Defense Medical Center
Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 23-8 (2013)
Shandong University of Technology
Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 60: 1-9 (2013)
Universidad Del Valle
Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 81: 399-407 (2013)
Southeast University
Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 702-5 (2013)
Birla Institute of Technology
Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 608-17 (2013)
The University of Tokyo
Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 693-702 (2013)
Arizona State University
Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptorß (TRß) selective agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 592-607 (2013)
Kissei Pharmaceutical
A formyl peptide substituted with a conformationally constrained phenylalanine residue evokes a selective immune response in human neutrophils.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 668-75 (2013)
Saga University
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Medchemcomm 3: 699-709 (2012)
Moffitt Cancer Center
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 991-996 (2012)
TBA
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Biol Chem 288: 5149-56 (2013)
John Innes Centre
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 676-83 (2013)
The Hong Kong University of Science and Technology
Recent development of potent analogues of oxazolidinone antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 577-91 (2013)
National Medicines Institute
Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-ylß-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 748-65 (2013)
Kissei Pharmaceutical
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 663-8 (2013)
Universit£
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 682-6 (2013)
National Center For Advancing Translational Sciences
Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aß aggregation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 440-3 (2012)
Baskent University
Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging investigations for neural oxytocin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 902-6 (2013)
Yerkes National Primate Research Center
Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 241-53 (2013)
University of T£Bingen
Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 29-35 (2013)
Universit£
Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymeraseß.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 403-11 (2012)
Kobe Gakuin University
Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1410-8 (2013)
National University of La Plata
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 795-804 (2013)
Heidelberg University
Novel benzoxazole inhibitors of mPGES-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 907-11 (2013)
Pfizer
Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 728-32 (2013)
Daiichi Sankyo
Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 733-6 (2013)
Riken Advanced Science Institute
Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5-tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 720-3 (2013)
Guizhou University
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 791-6 (2013)
Merck Research Laboratories
Inhibition of theß-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: identification of the first inhibitor with anti-mycobacterial activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 740-3 (2013)
Universidad Nacional De Rosario
A-ring modification of SCH 900229 and related chromene sulfone ?-secretase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 850-3 (2013)
Merck Research Laboratories
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 669-72 (2013)
Dainippon Sumitomo Pharma
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 715-9 (2013)
Universit£
Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 802-5 (2013)
Monash Institute of Pharmaceutical Sciences
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 897-901 (2013)
Genentech
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 687-92 (2013)
The Ohio State University
Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 844-9 (2013)
Merck Research Laboratories
Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 673-8 (2013)
Chugai Pharmaceutical
Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 430-4 (2012)
Paris-Sud University
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 767-72 (2013)
Pfizer
A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [(125)I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 869-72 (2013)
University of Pennsylvania
Lead optimization of isocytosine-derived xanthine oxidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 834-8 (2013)
Piramal Healthcare
Design and synthesis of tricyclic cores for kinase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 693-8 (2013)
Abbott Bioresearch Center
Near native binding of a fluorescent serotonin conjugate to serotonin type 3 receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 773-5 (2013)
Washington State University
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 766-78 (2013)
The University of Sydney
Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 304-9 (2013)
North Maharashtra University
Enhanced bioactivity of silybin B methylation products.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 742-7 (2013)
University of North Carolina At Greensboro
Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 811-5 (2013)
Janssen Research and Development
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 1114-9 (2013)
Pfizer
Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 785-90 (2013)
Janssen-Cilag
Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 706-10 (2013)
Astrazeneca
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 182-200 (2013)
Purdue University
Synthesis and Biological Evaluation of a Biotinylated Paclitaxel With an Extra-Long Chain Spacer Arm.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 745-748 (2012)
University of Minnesota
Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 940-51 (2013)
University of Copenhagen
Structural-functional studies of Burkholderia cenocepacia D-glycero-ß-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1405-17 (2013)
Mcmaster University
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 1034-1038 (2012)
TBA
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 407-11 (2012)
Bristol-Myers Squibb Research and Development
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 466-71 (2012)
Merck Research Laboratory
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 84-96 (2013)
University of Zurich
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives ina1-adrenergic and 5-HT1A receptor binding sites recognition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 584-8 (2013)
University of Camerino
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 521-33 (2013)
University of Ljubljana
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 660-70 (2013)
University of Oxford
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 427-36 (2013)
Heinrich Heine Universit£T
Trimeric hemibastadin congener from the marine sponge Ianthella basta.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 76: 121-5 (2013)
Heinrich-Heine University
MMP inhibition by barbiturate homodimers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 444-7 (2012)
Trinity College
Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 579-83 (2012)
Korea University
Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 514-22 (2013)
Jagiellonian University Medical College
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 436-47 (2012)
University of Bonn
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 448-55 (2012)
Nanjing University
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 456-65 (2013)
Universit£
Design, synthesis and molecular docking ofa,ß-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 388-94 (2012)
Soochow University
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 422-5 (2013)
Glaxosmithkline Research & Development
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 472-5 (2012)
Praecis Pharmaceuticals Incorporated (Currently Glaxosmithkline)
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 437-50 (2013)
TBA
Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 568-83 (2013)
Xenon Pharmaceuticals
Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1113-23 (2013)
University of Michigan
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 15-30 (2013)
Vanderbilt University School of Medicine
Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 839-843 (2012)
TBA
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 293-300 (2013)
Latvian Association of Human Genetics
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 781-95 (2013)
University of California
Synthesis and evaluation ofa-thymidine analogues as novel antimalarials.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10948-57 (2012)
University of Dundee
Boron-based inhibitors of acyl protein thioesterases 1 and 2.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chembiochem 14: 115-22 (2013)
Technical University of Dortmund
Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 283-95 (2013)
Universit£
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 412-6 (2012)
Vanderbilt University Medical Center
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 528-31 (2012)
The University of Arizona
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 492-5 (2012)
Universit£
Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 543-7 (2012)
Astrazeneca
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 417-21 (2012)
Columbia University
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 210-9 (2013)
The University of Queensland
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 547-55 (2013)
University of Oxford
Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 301-19 (2013)
Pfizer
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 569-73 (2012)
Astex Pharmaceuticals
Small molecule amides as potent ROR-¿ selective modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 532-6 (2012)
The Scripps Research Institute
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 235-42 (2013)
University of Santiago De Compostela
An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 254-63 (2013)
University of Chicago
Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10896-908 (2012)
Microbiotix
Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 28: 1316-23 (2013)
Solapur University
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 547-52 (2012)
Hong Kong University of Science and Technology
Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 220-40 (2013)
Astrazeneca
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 176-82 (2013)
Second Military Medical University
Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 160-7 (2013)
Peking University
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 141-9 (2013)
Dalian University of Technology
Sirtuins as emerging anti-parasitic targets.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 132-40 (2013)
Jiangsu University
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 532-9 (2012)
Department of Pharmaceutical Chemistry of Aristotle University of Thessaloniki
Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 426-9 (2012)
Universidad Complutense
Novel cinnoline-based inhibitors of LRRK2 kinase activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 71-4 (2012)
Elan Pharmaceuticals
Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 117-8 (2013)
Hokkaido University
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 28-41 (2012)
Takeda Pharmaceutical
Discovery of novela1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 196-204 (2012)
H. Lundbeck
A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 42-61 (2012)
Daiichi Sankyo
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 47-54 (2012)
University of Namur
The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 66-70 (2012)
Glaxosmithkline
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 37-41 (2012)
Vanderbilt University School of Medicine
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 537-42 (2012)
Yuhan Research Institute
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 85-9 (2012)
Universit£
Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 132-7 (2012)
Ku Leuven
Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 75-80 (2012)
Kyung Hee University
Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 125-31 (2012)
University of Paris
Facile synthesis and characterization of novel pyrazole-sulfonamides and their inhibition effects on human carbonic anhydrase isoenzymes.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 21-7 (2012)
Dumlupinar University
Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 81-4 (2013)
Tohoku Pharmaceutical University
Virtual Screening of CB2 Receptor Agonists from Bayesian Network and High-Throughput Docking: Structural Insights into Agonist-Modulated GPCR Features.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chem Biol Drug Des 81: 442-454 (2013)
Universite Lille-Nord de France
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 345-56 (2013)
F. Hoffmann-La Roche
Peptide-conjugated pterins as inhibitors of ricin toxin A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 320-9 (2013)
Toho University
Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 201-9 (2013)
Centre For Addiction and Mental Health
3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 264-75 (2013)
Technische Universit£T Braunschweig
Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10972-94 (2012)
Glaxosmithkline
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 186-95 (2012)
Karolinska Institutet
Identification of new potent GPR119 agonists by combining virtual screening and combinatorial chemistry.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 11031-41 (2012)
Boehringer Ingelheim Pharma
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 101-10 (2013)
Al. I. Cuza University of Iasi
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 91-100 (2013)
Sapienza University of Rome
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 75-90 (2013)
Universidade Do Porto
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 11-20 (2012)
Dalian University of Technology
QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1404-9 (2013)
Romanian Academy
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 179-82 (2012)
The General Hospital of Chinese People'S Liberation Army
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 169-73 (2012)
Astrazeneca
Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 90-5 (2012)
Shionogi
Tetrahydro-ß-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 138-42 (2012)
Sapienza University of Rome
Identification of novel chromenone derivatives as interleukin-5 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 31-8 (2013)
Chungnam National University
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 59: 1-6 (2013)
The Chinese University of Hong Kong
Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 119-24 (2012)
Astrazeneca
Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 375-81 (2012)
Kyorin Pharmaceutical
Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 223-7 (2012)
Vanderbilt University Medical Center
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 256-60 (2012)
Kochi Medical School
The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 268-72 (2012)
Kitasato University
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 163-8 (2012)
University of Alberta
Fluorescent ligands for adenosine receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 26-36 (2012)
National Institute of Diabetes and Digestive and Kidney Diseases
Macrolactonolides: a novel class of anti-inflammatory compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 321-32 (2012)
Glaxosmithkline
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1419-26 (2013)
Ecole Nationale Sup£Rieure De Chimie De Montpellier
Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 311-20 (2012)
Tokyo University of Science
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 257-68 (2012)
Ghent University
Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 62-9 (2012)
China Pharmaceutical University
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 70-83 (2012)
Takeda Pharmaceutical
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 146-52 (2012)
Universit£
Synthesis and biological evaluation of¹8F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 215-22 (2012)
Key Laboratory of Radiopharmaceuticals (Beijing Normal University)
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10958-71 (2012)
Genentech
Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 97-108 (2013)
Chinese Academy of Medical Sciences and Peking Union Medical College
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 143-6 (2012)
University of Bayreuth
Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 11042-51 (2012)
National Institute of Radiological Sciences
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10937-47 (2012)
Sapienza University of Rome
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 11022-30 (2012)
University of Cape Town
PPAR¿ agonist from Chromolaena odorata.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 75: 2076-81 (2012)
Hebei Medical University
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10863-84 (2012)
Seoul National University
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4027-33 (2013)
University of Oxford
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 351-4 (2012)
Janssen Research and Development
DNA cloning, characterization, and inhibition studies of ana-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10742-8 (2012)
Istituto Di Biochimica Delle Proteine-Cnr
Cyanobacterial peptides as a prototype for the design of potentß-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10749-65 (2012)
University of Florida
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 668-672 (2012)
The Scripps Research Institute
Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 297-300 (2012)
Shenyang Pharmaceutical University
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 194-7 (2012)
Pfizer
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 346-50 (2012)
Vanderbilt University Medical Center
QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 261-3 (2013)
Astrazeneca
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 330-5 (2012)
Bristol-Myers Squibb Research and Development
Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 365-72 (2012)
Swami Ramanand Teerth Marathwada University
Pharmacophore identification of c-Myc inhibitor 10074-G5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 370-4 (2012)
University of Maryland
Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 303-10 (2012)
University of Utah
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 11062-6 (2012)
University of Bradford
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10909-17 (2012)
University of Lille
Kinetic and in silico analysis of thiazolidin-based inhibitors of a-carbonic anhydrase isoenzymes.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 28: 370-4 (2013)
Ondokuz Mayis University
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 283-94 (2012)
Universita' Di Firenze
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 60-72 (2013)
Universit�
Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 371-5 (2013)
Imperial College
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1451-64 (2013)
University of Lille
A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 323-6 (2012)
National Institute On Drug Abuse-Intramural Research Program
Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 75: 2193-9 (2012)
San Francisco State University
Development of second-generation indole-based dynamin GTPase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 46-59 (2013)
The University of Newcastle
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10918-36 (2012)
Universidade Federal De Pernambuco
An anthraquinone scaffold for putative, two-face Bim BH3a-helix mimic.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10735-41 (2012)
Dalian University of Technology
Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4041-4 (2013)
Purdue University
On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 355-9 (2012)
Virginia Commonwealth University
Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrinavß3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 23: 340-5 (2012)
University of California
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 519-32 (2012)
University of Bologna
Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 504-12 (2012)
Fudan University
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7306-8 (2012)
Frederick National Laboratory For Cancer Research
Characterization of human carbonic anhydrase XII stability and inhibitor binding.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1431-6 (2013)
Vilnius University Institute of Biotechnology
HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10405-13 (2012)
University of Osnabr£Ck
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 405-17 (2012)
Sapienza University of Rome
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7523-9 (2012)
Pfizer
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10652-61 (2012)
Astrazeneca
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10490-500 (2012)
University of Bologna
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10424-36 (2012)
National Research Center
Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10644-51 (2012)
Bristol-Myers Squibb Research & Development
Synthesis and structure-activity relationship of (E)-phenoxyacrylic amide derivatives as hypoxia-inducible factor (HIF) 1a inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10564-71 (2012)
Dongguk University-Seoul
Virtual screening and QSAR study of some pyrrolidine derivatives asa-mannosidase inhibitors for binding feature analysis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6945-59 (2012)
Universidade Do Porto 687
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 396-404 (2012)
Avenue De L'Universit£
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10551-63 (2012)
Johns Hopkins University
Rational design of highly selective spleen tyrosine kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10414-23 (2012)
Hoffmann-La Roche
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10700-15 (2012)
Bar-Ilan University
Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10572-83 (2012)
Vu University Amsterdam
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 368-76 (2012)
Universit£
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7302-5 (2012)
Astrazeneca
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7309-13 (2012)
Frederick National Laboratory For Cancer Research
Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7371-5 (2012)
Amgen
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10791-5 (2012)
Universit£
Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10475-89 (2012)
Chinese Academy of Sciences
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7326-9 (2012)
Takeda Pharmaceutical
Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7314-21 (2012)
Nycomed Pharma
Identification of novel mPGES-1 inhibitors through screening of a chemical library.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7335-9 (2012)
Kookmin University
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7119-27 (2012)
Devi Ahilya Vishwavidyalaya
Brominated aromatic furanones and related esters from the ascidian Synoicum sp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 75: 2055-61 (2012)
Seoul National University
Principles and applications of halogen bonding in medicinal chemistry and chemical biology.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 1363-88 (2013)
Eberhard-Karls University
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10387-404 (2012)
University of Siena
Structural optimization of 2,5-thiophene amides as highly potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 167-81 (2013)
Saarland University
Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 596-601 (2012)
TBA
Discovery of a novel series of 4-quinolone JNK inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7381-7 (2012)
Roche Palo Alto
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7702-6 (2012)
Astrazeneca
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7388-92 (2012)
Vanderbilt University Medical Center
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7340-4 (2012)
Rensselaer Polytechnic Institute
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7451-5 (2012)
Pusan National University
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7030-9 (2012)
Purdue University
Design, synthesis and in vitro anti-proliferative activity of 4,6-quinazolinediamines as potent EGFR-TK inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 61: 132-45 (2013)
Misr International University
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7456-60 (2012)
Dongguk University-Seoul
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7672-6 (2012)
RhôNe-Poulenc Rorer
Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7431-5 (2012)
Suven Life Sciences
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7357-62 (2012)
Janssen Research and Development
New diterpene furanoids from the Antarctic lichen Huea sp.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7393-6 (2012)
Silla University
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7345-50 (2012)
University of Paris
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7069-82 (2012)
Simon Fraser University
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7214-22 (2012)
University College of Science
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7555-61 (2012)
Korea Institute of Science and Technology
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10532-9 (2012)
Universit£
Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrinaVß3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10460-74 (2012)
Universit£
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
ACS Chem Biol 8: 387-96 (2013)
University of St. Andrews
Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARa.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 317-22 (2012)
Universit£
Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10540-50 (2012)
Chinese Academy of Sciences
Design and synthesis of procollagen C-proteinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7397-401 (2012)
Fibrogen
Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 75: 2012-2015 (2012)
TBA
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10523-31 (2012)
Universit£
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective¿ opioid receptor agonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10302-6 (2012)
University of Innsbruck
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 353-61 (2013)
Glaxosmithkline
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 287-98 (2012)
Sapienza University of Rome
Synthesis, in silico, in vitro, and in vivo investigation of 5-[¹¹C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 272-80 (2012)
Universidad De Talca
Purpuroines A-J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6924-8 (2012)
Peking University
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7376-80 (2012)
Corcept Therapeutics
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7551-4 (2012)
Kitasato University
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7471-4 (2012)
University of Strasbourg
Synthesis of novel¿¿3 receptor ligands via an unusual Knoevenagel condensation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7578-81 (2012)
Moscow State University
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10771-5 (2012)
Zafes/Liff/Osf Goethe-University Frankfurt
Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFß signaling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9946-57 (2012)
Human Biomolecular Research Institute
Type II Ligands as Chemical Auxiliaries To Favor Enzymatic Transformations by P450 2E1.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Chembiochem 13: 2527-36 (2012)
Mcgill University
Molecular cloning and pharmacological characterisation of a tyramine receptor from the rice stem borer, Chilo suppressalis (Walker).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pest Manag Sci 69: 126-34 (2013)
Zhejiang University
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7653-8 (2012)
Exelixis
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7667-71 (2012)
Technische Universit£T Darmstadt
Azabenzthiazole inhibitors of leukotriene A4 hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7504-11 (2012)
Janssen Research and Development
3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7012-29 (2012)
The State University of New Jersey
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9793-809 (2012)
Targacept
Core refinement toward permeable ?-secretase (BACE-1) inhibitors with low hERG activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 4181-205 (2013)
Astrazeneca
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10501-11 (2012)
Universit£
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 228-36 (2012)
Peking University
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selectivea1B-adrenoceptor antagonist.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 184-91 (2012)
Universit£
Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 171-83 (2012)
Universit£
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 160-70 (2012)
University of Ljubljana
Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 136-52 (2012)
Zydus Research Centre
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 117-27 (2012)
Universidade De S£O Paulo
Synthesis and docking studies of novel antitumor benzimidazoles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6989-7001 (2012)
National Research Center
Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7206-13 (2012)
University of Florence
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7051-8 (2012)
Takeda Pharmaceutical
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7184-93 (2012)
University of Thessaly
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7040-50 (2012)
North-West University
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective protein tyrosine phosphatase 1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7518-22 (2012)
Roche Research Center
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7641-6 (2012)
The University of Sydney
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7543-6 (2012)
Piramal Healthcare
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase¿ inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7534-8 (2012)
Taisho Pharmaceutical
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7367-70 (2012)
North-West University
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7677-82 (2012)
Daiichi Sankyo
Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7512-7 (2012)
Boehringer Ingelheim (Canada)
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7735-8 (2012)
Ruprecht-Karls-Universit£T Heidelberg
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7486-9 (2012)
Chugai Pharmaceutical
Fluorescent nitrile-based inhibitors of cysteine cathepsins.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7715-8 (2012)
University of Bonn
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7440-3 (2012)
East China University of Science and Technology
Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1477-82 (2013)
Karamanoglu Mehmetbey University
Ion channels as therapeutic targets: a drug discovery perspective.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 593-624 (2013)
Pfizer
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9856-67 (2012)
University of Antwerp
The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 818-822 (2012)
TBA
Clinical pharmacokinetics, metabolism, and drug-drug interaction of carfilzomib.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 230-7 (2012)
Onyx Pharmaceuticals
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-ß type I receptor inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7128-38 (2012)
Taisho Pharmaceutical
Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 7155-9 (2012)
Istanbul University
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug-drug interaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7605-9 (2012)
Pfizer
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7697-701 (2012)
Kitasato University
Synthesis and evaluation of 3-¹²³I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic ?4?2 receptor imaging agent.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7610-4 (2012)
University of California - Irvine
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: optimising in vivo clearance.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7707-10 (2012)
Astrazeneca
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10610-29 (2012)
Astrazeneca
Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10685-99 (2012)
Sichuan University
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9562-75 (2012)
Kyoto Prefectural University of Medicine
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6ß-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selectiveµ opioid receptor Agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10118-29 (2012)
Virginia Commonwealth University
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 84-97 (2012)
Universit£
Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 4004-10 (2013)
Osaka University
Fluorescence study for selecting specific ligands toward HER2 receptor: an example of receptor fragment approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 61: 116-21 (2013)
Institute of Biostructures and Bioimages
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7627-33 (2012)
Genentech
Modification of a promiscuous inhibitor shifts the inhibition from¿-secretase to FLT-3.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7634-40 (2012)
Technische Universit£T Darmstadt
Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10307-11 (2012)
Amgen
a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10347-62 (2012)
University of Toyama
2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9817-30 (2012)
Saarland University
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7615-22 (2012)
Abbott Laboratories
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7711-4 (2012)
Kitasato University
Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7662-6 (2012)
Universit£
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7183-8 (2012)
Northeast Ohio Medical University
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7011-4 (2012)
North Maharashtra University
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9549-61 (2012)
Vrije Universiteit Brussel
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9693-707 (2012)
Universit£
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3ß inhibitors through virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7232-6 (2012)
Fudan University
Novel azulene derivatives for the treatment of erectile dysfunction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7151-4 (2012)
Friedrich-Alexander University
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7169-73 (2012)
Mrc Technology
Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7087-91 (2012)
Glaxosmithkline
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6795-802 (2012)
Shandong University
Carbonic anhydrase IX as a target for metastatic disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1470-6 (2013)
University of Manchester
O-Aryla,ß-d-ribofuranosides: synthesis& highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6821-30 (2012)
University of Delhi
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9654-68 (2012)
Universit£
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9847-55 (2012)
Merck Research Laboratories
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10797-822 (2012)
University of Genoa
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9492-509 (2012)
Chinese Academy of Sciences
Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10022-32 (2012)
Research Triangle Institute
Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10047-63 (2012)
Pfizer
Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9751-62 (2012)
H. Lee Moffitt Cancer Center and Research Institute
Identification of small molecule inhibitors of amyloidß-induced neuronal apoptosis acting through the imidazoline I(2) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9838-46 (2012)
Imim-Hospital Del Mar Research Institute and University Pompeu Fabra
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9831-7 (2012)
Pfizer
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9875-90 (2012)
Universit£
New adamantane phenylalkylamines withs-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10241-61 (2012)
National and Kapodistrian University of Athens
Lanostanoids from fungi: a group of potential anticancer compounds.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 75: 2016-2044 (2012)
TBA
General synthesis ofß-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10297-301 (2012)
University of Copenhagen
Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9998-10009 (2012)
University of Illinois At Chicago
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9914-28 (2012)
Mutabilis
The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7084-6 (2012)
Wayne State University
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7100-5 (2012)
Pfizer
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)¿isoleucine(315) mutant.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10033-46 (2012)
Chinese Academy of Sciences
Target Selectivity of FimH Antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9810-6 (2012)
University of Basel
Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10136-47 (2012)
Astrazeneca
Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9531-40 (2012)
Johannes Gutenberg University of Mainz
Bicyclization and tethering to albumin yields long-acting peptide antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10187-97 (2012)
Ecole Polytechnique F�D�Rale De Lausanne
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 58: 30-43 (2012)
Universit£
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 311-22 (2012)
University of Nottingham
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7207-13 (2012)
Merck Research Laboratories
Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7214-8 (2012)
University of Maryland
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7189-93 (2012)
Boehringer Ingelheim Pharmaceuticals
Prohormone-substrate peptide sequence recognition by peptidylglycinea-amidating monooxygenase and its reflection in increased glycolate inhibitor potency.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7015-8 (2012)
Australian National University
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7219-22 (2012)
Amri
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7155-62 (2012)
Shandong University
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7223-6 (2012)
Merck Research Laboratories
Specific interactions between adenosine and streptavidin/avidin.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7052-5 (2012)
Chinese Academy of Sciences
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6856-61 (2012)
Savannah State University
Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7106-9 (2012)
Monash University (Parkville Campus)
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7127-30 (2012)
Merck Research Laboratories
Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7075-9 (2012)
Daiichi Sankyo
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9589-606 (2012)
Universit£
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10277-81 (2012)
Siena Biotech
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10074-89 (2012)
Northeastern University
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10229-40 (2012)
The Institute of Cancer Research
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7119-22 (2012)
Pfizer
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7097-9 (2012)
Instituto De Qu£Mica Avanzada De Catalu£A
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7135-41 (2012)
The Scripps Research Institute
In vivo activity of an azole series of CCR2 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7252-5 (2012)
Glaxosmithkline
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 296-301 (2012)
Instituto De Qu£Mica Org£Nica General (Csic)
Ana-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1465-9 (2013)
Istituto Di Biochimica Delle Proteine (Ibp)
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10272-6 (2012)
Universit£
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9643-53 (2012)
Bristol-Myers Squibb
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9576-88 (2012)
University of Bonn
Small molecules that target protein misfolding.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10823-43 (2012)
Pfizer
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 808-813 (2012)
TBA
Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 149-58 (2012)
Nippon Boehringer Ingelheim
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6831-9 (2012)
University of Copenhagen
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7142-5 (2012)
Universit£
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7036-40 (2012)
Toray Industries
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9973-87 (2012)
University of Pittsburgh
Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8770-89 (2012)
Janssen-Cilag
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7237-42 (2012)
East China Normal University
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 7041-4 (2012)
Hebei University
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibita- andß-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9619-29 (2012)
Universit£
Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10148-59 (2012)
Yale University
An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9722-34 (2012)
Novartis Pharma
Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 378-382 (2012)
TBA
Selected C7-substituted chromone derivatives as monoamine oxidase inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Bioorg Chem 1-11 (2012)
North-West University
Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Ka inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 225-33 (2012)
Universit£
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6751-7 (2012)
Duke University Medical Center
Recent results in protein kinase inhibition for tropical diseases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6788-93 (2012)
Montclair State University
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6669-79 (2012)
Abo Akademi University
Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-ylß-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6598-612 (2012)
Kissei Pharmaceutical
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6709-23 (2012)
Fondazione Irccs Istituto Nazionale Dei Tumori
Synthesis and structure-activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6559-78 (2012)
Eisai
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6648-54 (2012)
Nanjing University
Development of anti-coxsackievirus agents targeting 3C protease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6952-6 (2012)
Gwangju Institute of School of Life Sciences
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6923-8 (2012)
Vanderbilt University Medical Center
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10090-107 (2012)
Genentech
Organosilicon molecules with medicinal applications.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 56: 388-405 (2013)
University of California Davis
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8903-25 (2012)
Roche R & D Center China
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 176-84 (2012)
Jamia Hamdard (Hamdard University)
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 85-101 (2012)
La Trobe University
Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 41-50 (2012)
Universit£
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6888-95 (2012)
Astrazeneca
Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6854-7 (2012)
Nankai University
In vivo and in vitro effect of androstene derivatives as 5a-reductase type 1 enzyme inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 28: 1247-54 (2013)
National University of Mexico City
Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10130-5 (2012)
Academy of Sciences of The Czech Republic
A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10160-76 (2012)
University of Medicine and Dentistry of New Jersey
Optimized 5-membered heterocycle-linked pterins for the inhibition of Ricin Toxin A.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 588-591 (2012)
TBA
Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Med Chem Res 21: 3455-3459 (2012)
Jagiellonian University Medical College
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 134-42 (2012)
Mashhad University of Medical Sciences
Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 112-25 (2012)
Clermont Universit£
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-ß type 1 receptor kinase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 74-84 (2012)
Ewha Womans University
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 59-64 (2012)
Hacettepe University
Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3ß (GSK-3ß).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 61: 95-103 (2013)
Fudan University
Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6974-9 (2012)
Astrazeneca
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6876-81 (2012)
Toray Industries
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6832-8 (2012)
Pfizer
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6828-31 (2012)
Bristol-Myers Squibb R&D
Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10108-17 (2012)
East China University of Science and Technology
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6867-70 (2012)
Shanghai Jiao Tong University
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 21-8 (2012)
China Pharmaceutical University
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 10-20 (2012)
Shanghai Jiao Tong University
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8721-34 (2012)
The Institute of Cancer Research
Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10287-91 (2012)
University of Troms£
Pyrimidine-fused heterocycle derivatives as a novel class of inhibitors for a-glucosidase.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 28: 1228-35 (2013)
Shiraz University
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9446-66 (2012)
Angelini Santa Palomba Research Center
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 10010-21 (2012)
Astrazeneca
Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9735-50 (2012)
Neurosearch Sweden
Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9900-13 (2012)
Universidad De Granada
Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversibleµ opioid receptor antagonist effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9868-74 (2012)
University of Bristol
Influence of chlorine or fluorine substitution on the estrogenic properties of 1-alkyl-2,3,5-tris(4-hydroxyphenyl)-1H-pyrroles.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9607-18 (2012)
Freie Universit£T Berlin
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8807-26 (2012)
Istituto Italiano Di Tecnologia
The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: a proof-of-concept study.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 57: 1-9 (2012)
Novartis Institutes For Biomedical Research
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aß aggregation, andß-secretase.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6739-50 (2012)
Central China Normal University
Rational design of apoptosis signal-regulating kinase 1 inhibitors: discovering novel structural scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Eur J Med Chem 61: 104-15 (2013)
Nas of Ukraine
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6758-69 (2012)
University of Warsaw
Adamantyl carboxamides and acetamides as potent human 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6394-402 (2012)
University of Bath
Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6256-9 (2012)
College of Pharmacy
Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6848-53 (2012)
East China University of Science and Technology
Viridin analogs derived from steroidal building blocks.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6919-22 (2012)
University of Connecticut
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6914-8 (2012)
Martin-Luther-University Halle-Wittenberg
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6980-5 (2012)
Suven Life Sciences
Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6573-6 (2012)
Genomics Institute of The Novartis Research Foundation
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6896-902 (2012)
'Al. I. Cuza' University of Iasi
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6260-75 (2012)
Sapienza University of Rome
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8879-90 (2012)
Imperial College
The story of a new insecticidal chemistry class: the diamides.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Pest Manag Sci 69: 7-14 (2013)
Syngenta Crop Protection M£Nchwilen
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9708-21 (2012)
Istituto Italiano Di Tecnologia
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Drug Metab Dispos 41: 60-71 (2012)
Tongji University
The therapeutic journey of benzimidazoles: a review.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6208-36 (2012)
Punjabi University
Role of the side chain stereochemistry in thea-glucosidase inhibitory activity of kotalanol, a potent naturala-glucosidase inhibitor. Part 2.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6321-34 (2012)
Kinki University
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6681-7 (2012)
Chungnam National University
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6661-4 (2012)
Research Triangle Institute
The discovery of CCR3/H1 dual antagonists with reduced hERG risk.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6688-93 (2012)
Astrazeneca
Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6712-5 (2012)
Ernst-Moritz-Arndt University Greifswald
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
BMC Biochem 13: 19 (2012)
Universit?? Degli Studi Di Siena
Acyl guanidine inhibitors ofß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9208-23 (2012)
Bristol-Myers Squibb Research
Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8502-14 (2012)
University of Michigan
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6313-20 (2012)
Csir-Central Drug Research Institute
The antitumor agent doxorubicin binds to Fanconi anemia group F protein.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6248-55 (2012)
Tokyo University of Science
Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6489-505 (2012)
University of Bonn
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6628-31 (2012)
Takeda California
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6554-8 (2012)
Shionogi
Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6596-601 (2012)
Nanjing University
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9929-45 (2012)
Targacept
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloidß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8969-73 (2012)
Kansas State University
Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8859-78 (2012)
Infinity Pharmaceuticals
Radiofluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid as inhibitors of prostate specific membrane antigen (PSMA) for the imaging of prostate cancer.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9510-20 (2012)
Bayer Healthcare
Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9055-68 (2012)
Pfizer
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
Nat Chem Biol 8: 920-5 (2012)
Astex Pharmaceuticals
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6459-64 (2012)
Chosun University
Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6375-83 (2012)
Okayama University
Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6335-43 (2012)
The University of Queensland
A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6344-55 (2012)
Universit£
Identification of pyrimidine derivatives as hSMG-1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6636-41 (2012)
Pfizer
Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6694-9 (2012)
Astrazeneca
Improving the affinity of naphthalene diimide ligand to telomeric DNA by incorporating Zn²¿ ions into its dipicolylamine groups.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6416-22 (2012)
Research Center For Bio-Microsensing Technology
Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6770-2 (2012)
Graduate School of Life Science and Systems Engineering
Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6356-65 (2012)
Nanjing University
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1511-5 (2013)
Universit£
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6366-74 (2012)
Purdue University
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6770-89 (2012)
Vernalis
4-Substituted-2-phenylquinazolines as inhibitors of BCRP.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6766-9 (2012)
University of Bonn
Formylated polyamines as peptidomimetics.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6580-2 (2012)
The Scripps Research Institute
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6762-5 (2012)
Johann Wolfgang Goethe University
4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8948-52 (2012)
University of Lille
New aminoimidazoles asß-secretase (BACE-1) inhibitors showing amyloid-ß (Aß) lowering in brain.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9297-311 (2012)
Astrazeneca
14-Alkoxy- and 14-acyloxypyridomorphinans:µ agonist/d antagonist opioid analgesics with diminished tolerance and dependence side effects.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8350-63 (2012)
Southern Research Institute
Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6756-61 (2012)
Astrazeneca
Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Nat Prod 75: 1675-82 (2012)
Central Laboratory of German Pharmacists
Enantiomerically pure 1,3-dioxanes as highly selective NMDA ands1 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8953-7 (2012)
Westf£Lische Wilhelms-Universit£T M£Nster
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 21: 1489-94 (2013)
Universidad Nacional De La Plata
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110ß isoform inhibitors through structure-based fragment optimisation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6665-70 (2012)
Astrazeneca
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6731-4 (2012)
University of Salford
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6745-9 (2012)
University of Hyderabad Campus
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6656-60 (2012)
Sanford-Burnham Medical Research Institute
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6721-7 (2012)
Medivir
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6632-5 (2012)
North-West University
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6621-7 (2012)
University of Illinois At Chicago
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6651-5 (2012)
Bristol-Myers Squibb
Discovery of phosphoinositide 3-kinases (PI3K) p110ß isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6671-6 (2012)
Astrazeneca
Structure-activity relationships of bergenin derivatives effect on a-glucosidase inhibition.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 28: 1162-70 (2013)
Kinki University
Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.![BDB](/images/logo_bindingdb.png)
![BDB](/images/logo_bindingdb.png)
J Enzyme Inhib Med Chem 28: 1199-204 (2013)
Yanbian University College of Pharmacy
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9434-45 (2012)
Sanford-Burnham Medical Research Institute
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9891-9 (2012)
University of Illinois At Chicago
Development of oseltamivir phosphonate congeners as anti-influenza agents.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8657-70 (2012)
The Genomics Research Center
Discovery of novel inhibitors of amyloid ?-peptide 1-42 aggregation.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9521-30 (2012)
Universidad De Zaragoza
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem 20: 6423-33 (2012)
Universidade Federal De Pernambuco
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
Bioorg Med Chem Lett 22: 6705-11 (2012)
Actelion Pharmaceuticals
5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8671-84 (2012)
University of Minnesota
Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 8603-14 (2012)
Vu University Amsterdam
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
J Med Chem 55: 9255-69 (2012)
Suven Life Sciences
From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.![EBI](/images/logo_chembl.png)
![EBI](/images/logo_chembl.png)
ACS Med Chem Lett 3: 721-725 (2012)
TBA
![BDB](/images/logo_bindingdb.png)
![EBI](/images/logo_chembl.png)