Compile Data Set for Download or QSAR
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Found 7 Enz. Inhib. hit(s) with all data for entry = 50043041
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50332963(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Affinity DataIC50:  270nMAssay Description:Negative allosteric modulation of mGlu3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50332963(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Affinity DataIC50:  296nMAssay Description:Negative allosteric modulation of mGlu2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2204436 | CHEMBL2385894)
Affinity DataIC50:  4.20E+3nMAssay Description:Negative allosteric modulation of human mGlu3 receptor assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50401091(CHEMBL2204436 | CHEMBL2385894)
Affinity DataIC50:  1.70E+4nMAssay Description:Negative allosteric modulation of human mGlu2 receptor assessed as Ca2+ flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50434976(CHEMBL2385886)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 15 mins prior to NADPH addition measured after 8 mins by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50434976(CHEMBL2385886)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 15 mins prior to NADPH addition measured after 8 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50434976(CHEMBL2385886)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 15 mins prior to NADPH addition measured after 8 mins by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed