Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 50022619
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0360nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0430nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.01 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0500nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0500nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.5 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0510nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.124nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.146nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.01 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.156nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.05 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.284nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.297nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.5 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.311nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells assessed as reduction in recovery of fluorescence intensity measured...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 72nMAssay Description:Inhibition of M2 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 97nMAssay Description:Inhibition of M1 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 120nMAssay Description:Binding affinity to L3MBTL3 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 350nMAssay Description:Binding affinity to L3MBTL3 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Inhibition of M4 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells assessed as disruption of foci formation by immunofluorescence assayMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 860nMAssay Description:Inhibition of alpha2C receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 890nMAssay Description:Inhibition of M3 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MBT domain containing L3MBTL1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MBT domain containing L3MBTL1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetMBT domain-containing protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MBT domain containing MBTD1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of KOR (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetTP53-binding protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of tudor domain containing 53BP1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4.30E+3nMAssay Description:Inhibition of M5 receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetPHD finger protein 20(Homo sapiens)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 5.60E+3nMAssay Description:Binding affinity to PHF20 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetMBT domain-containing protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of MBT domain containing MBTD1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 9.40E+3nMAssay Description:Binding affinity to L3MBTL1 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of DAT (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 4(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of MBT domain containing L3MBTL4 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetMBT domain-containing protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of MBT domain containing MBTD1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetPHD finger protein 20-like protein 1(Homo sapiens)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: >1.30E+4nMAssay Description:Binding affinity to tudor domain containing PHF20L1 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 4(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of MBT domain containing L3MBTL4 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetTP53-binding protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of tudor domain containing 53BP1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetMortality factor 4-like protein 1(Homo sapiens)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 2.89E+4nMAssay Description:Binding affinity to MRG15 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
TargetPHD finger protein 23(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHD finger domain containing PHF23 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase UHRF1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of tudor domain containing UHRF1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase UHRF1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of tudor domain containing UHRF1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase UHRF1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of tudor domain containing UHRF1 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHD finger domain containing JARID1A (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition ass...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHD finger domain containing JARID1A (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition ass...More data for this Ligand-Target Pair
TargetPHD finger protein 23(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHD finger domain containing PHF23 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetPHD finger protein 23(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHD finger domain containing PHF23 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PHD finger domain containing JARID1A (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition ass...More data for this Ligand-Target Pair
TargetScm-like with four MBT domains protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MBT domain containing SFMBT (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetScm-like with four MBT domains protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MBT domain containing SFMBT (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetScm-like with four MBT domains protein 1(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MBT domain containing SFMBT (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair


3D Structure (crystal)
