Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50043298
TargetCytochrome P450 2C8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 120nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 220nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation after 20 mins by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac 4'-hydroxylation after 20 mins by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 3.14E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as diclofenac 4'-hydroxylation after 20 mins by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation after 20 mins by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 4.33E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin 4'-hydroxylation after 20 mins by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as S-mephenytoin 4'-hydroxylation after 20 mins by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438846(CHEMBL2413881)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50438845(CHEMBL2413882)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed