Compile Data Set for Download or QSAR
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Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50040881
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of PI3Kalpha by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3Kdelta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PI3Kbeta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  26nMAssay Description:Inhibition of PI3Kgamma by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50156495(8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chro...)
Affinity DataIC50:  30nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50401463(CHEMBL1276684)
Affinity DataIC50:  130nMAssay Description:Inhibition of PI3Kalpha by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401463(CHEMBL1276684)
Affinity DataIC50:  140nMAssay Description:Inhibition of PI3Kbeta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401463(CHEMBL1276684)
Affinity DataIC50:  280nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401471(CHEMBL243810)
Affinity DataIC50:  300nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401462(CHEMBL1276718)
Affinity DataIC50:  360nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401468(CHEMBL244672)
Affinity DataIC50:  500nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401450(CHEMBL2204552)
Affinity DataIC50:  540nMAssay Description:Inhibition of PI3Kbeta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401459(CHEMBL2204545)
Affinity DataIC50:  620nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401463(CHEMBL1276684)
Affinity DataIC50:  720nMAssay Description:Inhibition of PI3Kgamma by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401471(CHEMBL243810)
Affinity DataIC50:  950nMAssay Description:Inhibition of PI3Kdelta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401461(CHEMBL1276748)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401466(CHEMBL1276651)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401471(CHEMBL243810)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PI3Kgamma by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401460(CHEMBL1276773)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401469(CHEMBL1276533)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401463(CHEMBL1276684)
Affinity DataIC50:  2.02E+3nMAssay Description:Inhibition of PI3Kdelta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401451(CHEMBL2204551)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition of PI3Kbeta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401453(CHEMBL2203798)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401465(CHEMBL1276683)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401467(CHEMBL1276622)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401471(CHEMBL243810)
Affinity DataIC50:  3.36E+3nMAssay Description:Inhibition of PI3Kbeta by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401450(CHEMBL2204552)
Affinity DataIC50:  3.41E+3nMAssay Description:Inhibition of PI3Kalpha by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401471(CHEMBL243810)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of PI3Kalpha by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401464(CHEMBL1276747)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401455(CHEMBL2204549)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401470(CHEMBL244253)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401457(CHEMBL2204547)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401452(CHEMBL2203800)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401456(CHEMBL2204548)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401454(CHEMBL2204550)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401450(CHEMBL2204552)
Affinity DataIC50:  1.78E+4nMAssay Description:Inhibition of PI3Kgamma by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50401451(CHEMBL2204551)
Affinity DataIC50:  2.05E+4nMAssay Description:Inhibition of PI3Kgamma by HTRF assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50401458(CHEMBL2204546)
Affinity DataIC50:  2.52E+4nMAssay Description:Inhibition of DNA-PK using EPPLSQEAFADLWKK as substrate after 5 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed