Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50040742
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 2nMAssay Description:Inhibition of 11betaHSD1 in human adipocytes assessed as cortisone to cortisol conversion by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392216BDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50: 2nMAssay Description:Inhibition of 11betaHSD1 in human adipocytes assessed as cortisone to cortisol conversion by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399353BDBM50399353(CHEMBL2177615)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399348BDBM50399348(CHEMBL2177620)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399346BDBM50399346(CHEMBL2180883)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399351BDBM50399351(CHEMBL2177617)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399336BDBM50399336(CHEMBL2177608)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399352BDBM50399352(CHEMBL2177616)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392216BDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 9nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399338BDBM50399338(CHEMBL2177606)
Affinity DataIC50: 9nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399347BDBM50399347(CHEMBL2177621)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399339BDBM50399339(CHEMBL2177605)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399345BDBM50399345(CHEMBL2180884)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399350BDBM50399350(CHEMBL2177618)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399341BDBM50399341(CHEMBL2177603)
Affinity DataIC50: 17nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399359BDBM50399359(CHEMBL2177610)
Affinity DataIC50: 18nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399340BDBM50399340(CHEMBL2177604)
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399356BDBM50399356(CHEMBL2177613)
Affinity DataIC50: 29nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399354BDBM50399354(CHEMBL2177614)
Affinity DataIC50: 43nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 86nMAssay Description:Inhibition of N-terminal 6-His tagged full length rat 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399337BDBM50399337(CHEMBL2177607)
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399355BDBM50399355(CHEMBL2177110)
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399349BDBM50399349(CHEMBL2177619)
Affinity DataIC50: 190nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399357BDBM50399357(CHEMBL2177612)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392217BDBM50392217(CHEMBL2153173)
Affinity DataIC50: 350nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399342BDBM50399342(CHEMBL2177602)
Affinity DataIC50: 380nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399358BDBM50399358(CHEMBL2177611)
Affinity DataIC50: 380nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392216BDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50: 750nMAssay Description:Inhibition of N-terminal 6-His tagged full length mouse 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399344BDBM50399344(CHEMBL2180885)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392216BDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50: 4.06E+3nMAssay Description:Inhibition of N-terminal 6-His tagged full length rat 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of N-terminal 6-His tagged full length mouse 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399343BDBM50399343(CHEMBL2177601)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of N-terminal 6-His tagged full length human 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 11beta-HSD2 assessed as conversion of cortisol to cortisone by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 17beta-HSD1 assessed as conversion of estrone to estradiol by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50399335BDBM50399335(CHEMBL2177609)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed