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Found 46 Enz. Inhib. hit(s) with all data for entry = 50040539
LigandPNGBDBM50395803(CHEMBL2165175)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395820(CHEMBL2165192)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395813(CHEMBL2165180)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395812(CHEMBL2165181)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395815(CHEMBL2165178)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395810(CHEMBL2165183)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  168nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110delta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  195nMAssay Description:Inhibition of human PI3K p110beta-mediated AKT phosphorylation at Ser473 in MDA-MB-468 cells after 2 hrs by fluorescence microplate cytometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395811(CHEMBL2165182)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395809(CHEMBL2165184)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395803(CHEMBL2165175)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395816(CHEMBL2165177)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395803(CHEMBL2165175)
Affinity DataIC50:  700nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395803(CHEMBL2165175)
Affinity DataIC50:  840nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50:  870nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395814(CHEMBL2165179)
Affinity DataIC50:  970nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395808(CHEMBL2165185)
Affinity DataIC50:  980nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395804(CHEMBL2165190)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395805(CHEMBL2165188)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395807(CHEMBL2165186)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395820(CHEMBL2165192)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395806(CHEMBL2165187)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395817(CHEMBL2165176)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395819(CHEMBL2165193)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  2.72E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395813(CHEMBL2165180)
Affinity DataIC50:  3.08E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395818(CHEMBL2165194)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395812(CHEMBL2165181)
Affinity DataIC50:  5.15E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395808(CHEMBL2165185)
Affinity DataIC50:  5.69E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395817(CHEMBL2165176)
Affinity DataIC50:  6.23E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395811(CHEMBL2165182)
Affinity DataIC50:  7.37E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395814(CHEMBL2165179)
Affinity DataIC50:  7.60E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395819(CHEMBL2165193)
Affinity DataIC50:  8.26E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395815(CHEMBL2165178)
Affinity DataIC50:  8.28E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395806(CHEMBL2165187)
Affinity DataIC50: >8.33E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395805(CHEMBL2165188)
Affinity DataIC50: >8.33E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  9.74E+4nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110bgamma expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395810(CHEMBL2165183)
Affinity DataIC50:  1.12E+5nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395809(CHEMBL2165184)
Affinity DataIC50:  1.49E+5nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395818(CHEMBL2165194)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395807(CHEMBL2165186)
Affinity DataIC50:  2.05E+5nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395816(CHEMBL2165177)
Affinity DataIC50:  2.12E+5nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395804(CHEMBL2165190)
Affinity DataIC50:  3.49E+5nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110alpha expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed