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Report error Found 142 Enz. Inhib. hit(s) with all data for entry = 50043249
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343835((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...)
Affinity DataKi:  50nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438113(CHEMBL1092481)
Affinity DataKi:  200nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438113(CHEMBL1092481)
Affinity DataKi:  500nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50312869(4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | CH...)
Affinity DataKi:  500nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299323((S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide ...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50343835((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438114(CHEMBL2409758)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50299323((S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide ...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438114(CHEMBL2409758)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438142(CHEMBL2409847)
Affinity DataIC50:  3nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438157(CHEMBL2409850)
Affinity DataIC50:  3nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438167(CHEMBL2409849)
Affinity DataIC50:  4nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438161(CHEMBL2409848)
Affinity DataIC50:  5nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438163(CHEMBL2409886)
Affinity DataIC50:  5nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438126(CHEMBL2407197)
Affinity DataIC50:  5nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438168(CHEMBL2409889)
Affinity DataIC50:  7nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438165(CHEMBL2409888)
Affinity DataIC50:  8nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438155(CHEMBL2409881)
Affinity DataIC50:  10nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438154(CHEMBL2409884)
Affinity DataIC50:  10nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438158(CHEMBL2407198)
Affinity DataIC50:  10nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438142(CHEMBL2409847)
Affinity DataIC50:  20nMAssay Description:Inhibition of mouse SphK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438167(CHEMBL2409849)
Affinity DataIC50:  20nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438143(CHEMBL2409891)
Affinity DataIC50:  20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438162(CHEMBL2409880)
Affinity DataIC50:  20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438132(CHEMBL2409865)
Affinity DataIC50:  20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438153(CHEMBL2409861)
Affinity DataIC50:  20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438164(CHEMBL2409883)
Affinity DataIC50:  20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438169(CHEMBL2409870)
Affinity DataIC50:  30nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438152(CHEMBL2409890)
Affinity DataIC50:  30nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438160(CHEMBL2409868)
Affinity DataIC50:  30nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438142(CHEMBL2409847)
Affinity DataIC50:  40nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438161(CHEMBL2409848)
Affinity DataIC50:  40nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438157(CHEMBL2409850)
Affinity DataIC50:  50nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438149(CHEMBL2409885)
Affinity DataIC50:  50nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438135(CHEMBL2409892)
Affinity DataIC50:  70nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Mouse)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438143(CHEMBL2409891)
Affinity DataIC50:  70nMAssay Description:Inhibition of mouse SphK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438150(CHEMBL2409879)
Affinity DataIC50:  70nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438159(CHEMBL2409877)
Affinity DataIC50:  80nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438133(CHEMBL2409859)
Affinity DataIC50:  80nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438166(CHEMBL2409867)
Affinity DataIC50:  90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438165(CHEMBL2409888)
Affinity DataIC50:  90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438169(CHEMBL2409870)
Affinity DataIC50:  90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438143(CHEMBL2409891)
Affinity DataIC50:  100nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438168(CHEMBL2409889)
Affinity DataIC50:  110nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438122(CHEMBL2409872)
Affinity DataIC50:  120nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438166(CHEMBL2409867)
Affinity DataIC50:  130nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438134(CHEMBL2409846)
Affinity DataIC50:  130nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438115(CHEMBL2409851)
Affinity DataIC50:  140nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438127(CHEMBL2407119)
Affinity DataIC50:  150nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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