Compile Data Set for Download or QSAR
Report error Found 142 Enz. Inhib. hit(s) with all data for entry = 50043249
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438157BDBM50438157(CHEMBL2409850)
Affinity DataIC50: 3nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438142BDBM50438142(CHEMBL2409847)
Affinity DataIC50: 3nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438167BDBM50438167(CHEMBL2409849)
Affinity DataIC50: 4nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438163BDBM50438163(CHEMBL2409886)
Affinity DataIC50: 5nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438126BDBM50438126(CHEMBL2407197)
Affinity DataIC50: 5nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438161BDBM50438161(CHEMBL2409848)
Affinity DataIC50: 5nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438168BDBM50438168(CHEMBL2409889)
Affinity DataIC50: 7nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438165BDBM50438165(CHEMBL2409888)
Affinity DataIC50: 8nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438154BDBM50438154(CHEMBL2409884)
Affinity DataIC50: 10nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438158BDBM50438158(CHEMBL2407198)
Affinity DataIC50: 10nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438155BDBM50438155(CHEMBL2409881)
Affinity DataIC50: 10nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Mouse)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438142BDBM50438142(CHEMBL2409847)
Affinity DataIC50: 20nMAssay Description:Inhibition of mouse SphK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438162BDBM50438162(CHEMBL2409880)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438164BDBM50438164(CHEMBL2409883)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438167BDBM50438167(CHEMBL2409849)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438153BDBM50438153(CHEMBL2409861)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438132BDBM50438132(CHEMBL2409865)
Affinity DataIC50: 20nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438160BDBM50438160(CHEMBL2409868)
Affinity DataIC50: 30nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438169BDBM50438169(CHEMBL2409870)
Affinity DataIC50: 30nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438152BDBM50438152(CHEMBL2409890)
Affinity DataIC50: 30nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438142BDBM50438142(CHEMBL2409847)
Affinity DataIC50: 40nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438161BDBM50438161(CHEMBL2409848)
Affinity DataIC50: 40nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438149BDBM50438149(CHEMBL2409885)
Affinity DataIC50: 50nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438157BDBM50438157(CHEMBL2409850)
Affinity DataIC50: 50nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50343835BDBM50343835((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...)
Affinity DataKi:  50nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438150BDBM50438150(CHEMBL2409879)
Affinity DataIC50: 70nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438135BDBM50438135(CHEMBL2409892)
Affinity DataIC50: 70nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Mouse)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataIC50: 70nMAssay Description:Inhibition of mouse SphK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438159BDBM50438159(CHEMBL2409877)
Affinity DataIC50: 80nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438155BDBM50438155(CHEMBL2409881)
Affinity DataEC50:  80nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438133BDBM50438133(CHEMBL2409859)
Affinity DataIC50: 80nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438165BDBM50438165(CHEMBL2409888)
Affinity DataIC50: 90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataEC50:  90nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438166BDBM50438166(CHEMBL2409867)
Affinity DataIC50: 90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438169BDBM50438169(CHEMBL2409870)
Affinity DataIC50: 90nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438143BDBM50438143(CHEMBL2409891)
Affinity DataIC50: 100nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438152BDBM50438152(CHEMBL2409890)
Affinity DataEC50:  100nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438168BDBM50438168(CHEMBL2409889)
Affinity DataIC50: 110nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438154BDBM50438154(CHEMBL2409884)
Affinity DataEC50:  110nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438167BDBM50438167(CHEMBL2409849)
Affinity DataEC50:  120nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438122BDBM50438122(CHEMBL2409872)
Affinity DataIC50: 120nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438163BDBM50438163(CHEMBL2409886)
Affinity DataEC50:  120nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438165BDBM50438165(CHEMBL2409888)
Affinity DataEC50:  130nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438166BDBM50438166(CHEMBL2409867)
Affinity DataIC50: 130nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438134BDBM50438134(CHEMBL2409846)
Affinity DataIC50: 130nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438162BDBM50438162(CHEMBL2409880)
Affinity DataEC50:  130nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438115BDBM50438115(CHEMBL2409851)
Affinity DataIC50: 140nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438127BDBM50438127(CHEMBL2407119)
Affinity DataIC50: 150nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50438164BDBM50438164(CHEMBL2409883)
Affinity DataIC50: 150nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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