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Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy.EBI
J Med Chem 60: 8847-8857 (2017)
Crystal Pharmatech
Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.EBI
Bioorg Med Chem Lett 27: 4812-4816 (2017)
Universit£
Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.EBI
J Med Chem 61: 84-97 (2018)
University Of Washington
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.EBI
J Med Chem 60: 8989-9002 (2017)
Celgene
Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT.EBI
J Med Chem 60: 8801-8815 (2017)
Tu Dortmund University
Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/?-Aminobutyric Acid Transporter 1 (BGT1).EBI
J Med Chem 60: 8834-8846 (2017)
University Of Copenhagen
Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism.EBI
J Med Chem 60: 8631-8646 (2017)
Dongguk University
Peptide therapeutics from venom: Current status and potential.EBI
Bioorg Med Chem 26: 2738-2758 (2018)
Peptides International
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.EBI
Bioorg Med Chem 25: 5995-6006 (2017)
Takeda Pharmaceutical
Challenges in the design of insulin and relaxin/insulin-like peptide mimetics.EBI
Bioorg Med Chem 26: 2827-2841 (2018)
University Of Melbourne
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.EBI
Bioorg Med Chem 25: 5917-5928 (2017)
Shenyang Pharmaceutical University
Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors.EBI
Bioorg Med Chem 25: 6024-6038 (2017)
Astellas Pharma
Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3',2':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5'-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes.EBI
Eur J Med Chem 140: 448-464 (2017)
Shanghai Institute Of Materia Medica
Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent.EBI
Eur J Med Chem 140: 435-447 (2017)
Lanzhou University
Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity inávitro.EBI
Eur J Med Chem 140: 421-434 (2017)
China Pharmaceutical University
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.EBI
Eur J Med Chem 140: 392-402 (2017)
Xinxiang Medical University
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.EBI
Eur J Med Chem 140: 383-391 (2017)
Shandong University
Covalent binding design strategy: A prospective method for discovery of potent targeted anticancer agents.EBI
Eur J Med Chem 142: 493-505 (2017)
Dalian Medical University
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.EBI
Bioorg Med Chem 25: 5981-5994 (2017)
Institute Of Physiologically Active Compounds Russian Academy Of Sciences
Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction.EBI
Bioorg Med Chem 25: 6007-6015 (2017)
Tokyo Institute Of Technology
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.EBI
Bioorg Med Chem Lett 27: 4838-4843 (2017)
Glaxosmithkline
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease.EBI
J Med Chem 60: 8858-8875 (2017)
Columbia University
C-Methylated Flavonoid Glycosides from Pentarhizidium orientale Rhizomes and Their Inhibitory Effects on the H1N1 Influenza Virus.EBI
J Nat Prod 80: 2818-2824 (2017)
Seoul National University
Chemical Approaches to Modulating Complement-Mediated Diseases.EBI
J Med Chem 61: 3253-3276 (2018)
The University Of Queensland
Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.EBI
J Med Chem 60: 8441-8455 (2017)
Gifu Pharmaceutical University
Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.EBI
Bioorg Med Chem Lett 27: 4832-4837 (2017)
St. John'S University
Berchemiosides A-C, 2-Acetoxy-?-phenylpentaene Fatty Acid Triglycosides from the Unripe Fruits of Berchemia berchemiifolia.EBI
J Nat Prod 80: 2778-2786 (2017)
Seoul National University
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists.EBI
J Med Chem 60: 8716-8730 (2017)
University Of Copenhagen
Modulators of 14-3-3 Protein-Protein Interactions.EBI
J Med Chem 61: 3755-3778 (2018)
Eindhoven University Of Technology
Potential Anti-inflammatory Effects of the Fruits of Paulownia tomentosa.EBI
J Nat Prod 80: 2659-2665 (2017)
Korea Research Institute Of Bioscience And Biotechnology
Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.EBI
J Med Chem 60: 8647-8660 (2017)
S£O Paulo State University (Unesp)
New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.EBI
Eur J Med Chem 140: 305-320 (2017)
Ludwig-Maximilians-University Munich
Pentacyclic triterpenes as?-glucosidase and?-amylase inhibitors: Structure-activity relationships and the synergism with acarbose.EBI
Bioorg Med Chem Lett 27: 5065-5070 (2017)
Dalian University Of Technology
Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies.EBI
Eur J Med Chem 140: 293-304 (2017)
China Pharmaceutical University
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.EBI
Bioorg Med Chem 25: 5849-5858 (2017)
University Of Genoa
Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase.EBI
Bioorg Med Chem 25: 5185-5193 (2017)
Konkuk University
Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.EBI
Bioorg Med Chem 25: 5859-5874 (2017)
University Of Auckland
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.EBI
Bioorg Med Chem Lett 27: 4858-4866 (2017)
Vanderbilt University
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine HEBI
Bioorg Med Chem Lett 27: 4914-4919 (2017)
Glaxosmithkline
Plasma-induced dimerization of phloridzin as a new class of anti-adipogenic agents.EBI
Bioorg Med Chem Lett 27: 4889-4892 (2017)
Daegu University
Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists.EBI
Bioorg Med Chem Lett 27: 4904-4907 (2017)
Asubio Pharma
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML.EBI
J Med Chem 60: 8407-8424 (2017)
Chinese Academy Of Sciences
Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action.EBI
J Med Chem 60: 8394-8406 (2017)
Showa Pharmaceutical University
Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor.EBI
J Med Chem 60: 9585-9598 (2017)
Zhaw Zurich University Of Applied Sciences
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.EBI
J Med Chem 60: 8336-8357 (2017)
National University Of Singapore
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).EBI
J Med Chem 60: 8011-8026 (2017)
Anacor Pharmaceuticals
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors.EBI
Bioorg Med Chem 25: 5799-5819 (2017)
Advinus Therapeutics
Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1.EBI
Bioorg Med Chem 26: 1206-1211 (2018)
Tufts University
The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPEBI
Bioorg Med Chem 25: 5875-5888 (2017)
University Of Alberta
PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.EBI
Bioorg Med Chem Lett 27: 5076-5081 (2017)
Seoul National University
Exploring Heme and Hemoglobin Binding Regions of Plasmodium Heme Detoxification Protein for New Antimalarial Discovery.EBI
J Med Chem 60: 8298-8308 (2017)
International Centre For Genetic Engineering And Biotechnology
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.EBI
J Med Chem 60: 8369-8384 (2017)
Abbvie
Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen.EBI
J Med Chem 60: 8192-8200 (2017)
University Of Copenhagen
Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.EBI
ACS Med Chem Lett 8: 981-986 (2017)
Astrazeneca
Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.EBI
ACS Med Chem Lett 8: 975-980 (2017)
Novartis Institutes For Biomedical Research
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-EBI
ACS Med Chem Lett 8: 969-974 (2017)
Wuxi Apptec (Shanghai)
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.EBI
ACS Med Chem Lett 8: 963-968 (2017)
University Of Florence
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.EBI
ACS Med Chem Lett 8: 947-952 (2017)
Janssen Research And Development
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.EBI
ACS Med Chem Lett 8: 941-946 (2017)
University Of Sassari
Design of Selective Benzoxazepin PI3K? Inhibitors Through Control of Dihedral Angles.EBI
ACS Med Chem Lett 8: 936-940 (2017)
Genentech
Design and Synthesis of EBI
ACS Med Chem Lett 8: 925-930 (2017)
Vanderbilt University School Of Medicine
Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand.EBI
ACS Med Chem Lett 8: 914-918 (2017)
University Of Iowa
Bruton's Tyrosine Kinase Inhibitors for the Treatment of Autoimmune Diseases and Cancers.EBI
ACS Med Chem Lett 8: 911-913 (2017)
Amri
New Substituted Cyanoindoline Derivatives as MAP3K14 Kinase Inhibitors for the Treatment of Cancer and Autoimmune Disorders.EBI
ACS Med Chem Lett 8: 908-910 (2017)
Amri
Modulating GluN2B for the Treatment of Neurological and Psychiatric Disorders.EBI
ACS Med Chem Lett 8: 905-907 (2017)
Amri
Discovery of N-substituted 7-azaindoles as PIM1 kinase inhibitors - Part I.EBI
Bioorg Med Chem Lett 27: 4730-4734 (2017)
Sanofi Genzyme
Design, synthesis and biological evaluation of novel histone deacetylase inhibitors incorporating 4-aminoquinazolinyl systems as capping groups.EBI
Bioorg Med Chem Lett 27: 4885-4888 (2017)
Shanghai Institute Of Pharmaceutical Industry
Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.EBI
Bioorg Med Chem Lett 27: 4908-4913 (2017)
Bristol-Myers Squibb
In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.EBI
J Med Chem 60: 8552-8564 (2017)
National Institute Of Biological Sciences, Beijing
New 5-HTEBI
Bioorg Med Chem 25: 5820-5837 (2017)
Dipartimento Di Farmacia Universit£
Structure-activity relationship study of?-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.EBI
Bioorg Med Chem Lett 27: 4770-4776 (2017)
Florida Institute Of Technology
Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ER?/VEGFR-2 ligands for treatment of breast cancer.EBI
Eur J Med Chem 140: 252-273 (2017)
China Pharmaceutical University
Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment.EBI
Bioorg Med Chem Lett 27: 4606-4613 (2017)
Korea Research Institute Of Chemical Technology
Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds ináthe design of free fatty acid receptor 1 (GPR40) agonists.EBI
Eur J Med Chem 140: 229-238 (2017)
Saint Petersburg State University
Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors.EBI
Eur J Med Chem 140: 212-228 (2017)
Shanghai Institute Of Pharmaceutical Industry
Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2YEBI
J Med Chem 60: 8425-8440 (2017)
University Of Bonn
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.EBI
J Med Chem 60: 8591-8605 (2017)
Astrazeneca
A potent neuromedin U receptor 2-selective alkylated peptide.EBI
Bioorg Med Chem Lett 27: 4626-4629 (2017)
Takeda Pharmaceutical
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.EBI
PLoS ONE 12: 1-16 (2017)
Pfizer
Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.EBI
J Med Chem 60: 8055-8070 (2017)
Indiana University School Of Medicine
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.EBI
J Med Chem 60: 9976-9989 (2017)
University Of California
Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.EBI
J Med Chem 60: 8170-8182 (2017)
University Of Minnesota
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.EBI
J Med Chem 60: 8083-8102 (2017)
Wuxi Apptec
Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.EBI
J Med Chem 60: 8160-8169 (2017)
Stockholm University
Structural Biology-Inspired Discovery of Novel KRAS-PDE? Inhibitors.EBI
J Med Chem 60: 9400-9406 (2017)
Second Military Medical University
In-cell production of a genetically-encoded library based on the ?-defensin RTD-1 using a bacterial expression system.EBI
Bioorg Med Chem 26: 1212-1219 (2018)
University Of Southern California
Design, synthesis and antitumor activity of Novel Sorafenib derivatives bearing pyrazole scaffold.EBI
Bioorg Med Chem 25: 5754-5763 (2017)
Jiangxi Science & Technology Normal University
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.EBI
Bioorg Med Chem Lett 27: 4755-4759 (2017)
University Of Manchester
Synthesis and evaluation of the NSCLC anti-cancer activity and physical properties of 4-aryl-N-phenylpyrimidin-2-amines.EBI
Bioorg Med Chem Lett 27: 4749-4754 (2017)
Kasetsart University
Discovery and optimization of oxadiazole-based FLAP inhibitors.EBI
Bioorg Med Chem Lett 27: 4652-4659 (2017)
Boehringer Ingelheim Pharmaceuticals
Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II.EBI
Bioorg Med Chem Lett 27: 4735-4740 (2017)
Sanofi Genzyme
Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modelling.EBI
Bioorg Med Chem Lett 27: 4635-4642 (2017)
Ningxia Medical University
Discovery of highly potent, selective, covalent inhibitors of JAK3.EBI
Bioorg Med Chem Lett 27: 4622-4625 (2017)
Bristol-Myers Squibb Research And Development
Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.EBI
Eur J Med Chem 140: 187-199 (2017)
University Of S£O Paulo
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection.EBI
J Med Chem 61: 2636-2651 (2018)
Abbvie
Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program.EBI
J Med Chem 60: 8321-8335 (2017)
Abbvie
Nanomolar Inhibitors of Glycogen Phosphorylase Based on?-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.EBI
J Med Chem 60: 9251-9262 (2017)
University Of Debrecen
Targeting breast cancer stem cells by novel HDAC3-selective inhibitors.EBI
Eur J Med Chem 140: 42-51 (2017)
National Taiwan University
Design, synthesis and structure-activity relationship studies of a focused library of pyrimidine moiety with anti-proliferative and anti-metastasis activities in triple negative breast cancer.EBI
Eur J Med Chem 140: 155-171 (2017)
Shenyang Pharmaceutical University
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.EBI
Eur J Med Chem 140: 118-127 (2017)
Xinyang Normal University
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.EBI
J Med Chem 60: 8115-8130 (2017)
Universit£
Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.EBI
J Med Chem 60: 7820-7834 (2017)
University Of Wisconsin-Madison
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase II?.EBI
Bioorg Med Chem Lett 27: 4687-4693 (2017)
Alma Mater Studiorum-University Of Bologna
Identifying novel factor XIIa inhibitors with PCA-GA-SVM developed vHTS models.EBI
Eur J Med Chem 140: 31-41 (2017)
The University Of Akron
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.EBI
Eur J Med Chem 140: 20-30 (2017)
South China University Of Technology
A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.EBI
Eur J Med Chem 140: 1-19 (2017)
Nirma University
Highly potent antiobesity effect of a short-length peptide YY analog in mice.EBI
Bioorg Med Chem 25: 5718-5725 (2017)
Takeda Pharmaceutical
Design, synthesis and biological evaluation of benzamide and phenyltetrazole derivatives with amide and urea linkers as BCRP inhibitors.EBI
Bioorg Med Chem Lett 27: 4698-4704 (2017)
St. John'S University
Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration.EBI
Bioorg Med Chem Lett 27: 4673-4677 (2017)
Glaxosmithkline
d-Amino acid mutation of PMI as potent dual peptide inhibitors of p53-MDM2/MDMX interactions.EBI
Bioorg Med Chem Lett 27: 4678-4681 (2017)
University Of Maryland
Pyrrolizines: Design, synthesis, anticancer evaluation and investigation of the potential mechanism of action.EBI
Bioorg Med Chem 25: 5637-5651 (2017)
Umm Al-Qura University
Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors.EBI
Eur J Med Chem 142: 424-458 (2017)
Central University Of Punjab
Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design.EBI
J Med Chem 60: 8708-8715 (2017)
University Of Vienna
Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.EBI
J Med Chem 60: 8515-8537 (2017)
Prexton Therapeutics
Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata.EBI
J Nat Prod 80: 2462-2471 (2017)
Huazhong University Of Science And Technology
Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A.EBI
Bioorg Med Chem 26: 1118-1126 (2018)
European Molecular Biology Laboratory (EMBL)
Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1.EBI
J Med Chem 60: 7984-7999 (2017)
University Of Manchester
Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis.BDB
ACS Chem Biol 12: 2682-2689 (2017)
University Of Konstanz
Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1).EBI
J Med Chem 60: 8246-8252 (2017)
National Cancer Institute-Bethesda
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).EBI
J Med Chem 60: 9162-9183 (2017)
Genentech
Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.EBI
Bioorg Med Chem 25: 5709-5717 (2017)
South China Agricultural University
Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.EBI
Bioorg Med Chem 25: 5726-5732 (2017)
National Institute Of Pharmaceutical Education And Research (Niper)
Analysis of the binding sites of vitamin D 1?-hydroxylase (CYP27B1) and vitamin D 24-hydroxylase (CYP24A1) for the design of selective CYP24A1 inhibitors: Homology modelling, molecular dynamics simulations and identification of key binding requirements.EBI
Bioorg Med Chem 25: 5629-5636 (2017)
Cardiff University
A prodrug design for improved oral absorption and reduced hepatic interaction.EBI
Bioorg Med Chem 25: 5569-5575 (2017)
Evestra
Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies.EBI
Eur J Med Chem 139: 961-981 (2017)
Svkm'S Dr. Bhanuben Nanavati College Of Pharmacy
Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.EBI
J Nat Prod 80: 2472-2477 (2017)
Michigan State University
Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.EBI
J Med Chem 60: 7965-7983 (2017)
Second Military Medical University
Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity.EBI
J Med Chem 60: 7928-7934 (2017)
University Of Florida
Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents.EBI
Bioorg Med Chem 25: 5216-5237 (2017)
Kyushu University
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.EBI
Eur J Med Chem 139: 936-946 (2017)
University Of Torino
Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.EBI
J Med Chem 60: 8145-8159 (2017)
East China University Of Science And Technology
Namalides B and C and Spumigins K-N from the Cultured Freshwater Cyanobacterium Sphaerospermopsis torques-reginae.EBI
J Nat Prod 80: 2492-2501 (2017)
University Of S£O Paulo
Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.EBI
J Med Chem 61: 2652-2679 (2018)
Albany College Of Pharmacy And Health Sciences
Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription.EBI
J Med Chem 60: 8218-8245 (2017)
Shanghai Institute Of Materia Medica (Simm)
?-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation.EBI
Bioorg Med Chem 25: 5613-5628 (2017)
Friedrich-Alexander University Erlangen-N£Rnberg
1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation.EBI
Bioorg Med Chem 25: 5548-5556 (2017)
Shandong University
Discovery of a novel, CNS penetrant MEBI
Bioorg Med Chem Lett 27: 4274-4279 (2017)
Vanderbilt University
Synthesis, in vitro ?-glucuronidase inhibitory potential and molecular docking studies of quinolines.EBI
Eur J Med Chem 139: 849-864 (2017)
University Of Karachi
Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors.EBI
Eur J Med Chem 139: 815-825 (2017)
Sun Yat-Sen University
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.EBI
Eur J Med Chem 139: 773-791 (2017)
University Of S£O Paulo
Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia.EBI
Eur J Med Chem 139: 762-772 (2017)
University Of South Australia
Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury.EBI
Eur J Med Chem 139: 726-740 (2017)
Wenzhou Medical University
1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.EBI
Eur J Med Chem 139: 698-717 (2017)
Instituto De Tecnologia Em F£Rmacos
Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.EBI
J Med Chem 60: 8131-8144 (2017)
Mayo Clinic
Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase.EBI
J Med Chem 60: 7910-7927 (2017)
University Of Ottawa
Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.EBI
J Med Chem 60: 7781-7798 (2017)
University Of Helsinki
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).EBI
J Med Chem 60: 7835-7849 (2017)
Pfizer
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroliEBI
J Med Chem 61: 599-618 (2018)
University Of Dundee
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.EBI
J Med Chem 60: 7725-7744 (2017)
Tu Dortmund University
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC.EBI
Eur J Med Chem 139: 674-697 (2017)
Chinese Academy Of Sciences
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI
J Med Chem 61: 2166-2210 (2018)
St. John'S University
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.BDB
ACS Chem Biol 12: 2619-2630 (2017)
Oxford University
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.EBI
J Med Chem 60: 7703-7724 (2017)
Goethe-University Frankfurt
Picomolar inhibition of?-galactosidase (bovine liver) attributed to loop closure.EBI
Bioorg Med Chem 25: 5194-5202 (2017)
University Of Arkansas
Recent developments in small molecule therapies for renal cell carcinoma.EBI
Eur J Med Chem 142: 383-392 (2017)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)
Recent advances in JAK3 inhibition: Isoform selectivity by covalent cysteine targeting.EBI
Bioorg Med Chem Lett 27: 4229-4237 (2017)
Eberhard-Karls-University Tuebingen
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.EBI
Bioorg Med Chem Lett 27: 4358-4369 (2017)
Beni-Suef University
Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.EBI
Bioorg Med Chem 25: 5513-5521 (2017)
Csir-Indian Institute Of Integrative Medicine
Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition.EBI
Eur J Med Chem 139: 633-643 (2017)
University Of Groningen
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 139: 612-632 (2017)
The University Of Sydney
Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).EBI
Eur J Med Chem 139: 587-611 (2017)
University Of Bonn
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.BDB
ACS Chem Biol 12: 2491-2497 (2017)
Istituto Italiano Di Tecnologia
Conjugates of 18?-glycyrrhetinic acid derivatives with 3-(1H-benzo[d]imidazol-2-yl)propanoic acid as Pin1 inhibitors displaying anti-prostate cancer ability.EBI
Bioorg Med Chem 25: 5441-5451 (2017)
Shenyang Pharmaceutical University
Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation.EBI
Bioorg Med Chem 25: 5531-5536 (2017)
La Trobe University
Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.EBI
Bioorg Med Chem Lett 27: 4383-4388 (2017)
Seoul National University
Synthesis and optimization of 4,5,6,7-tetrahydrooxazolo[4,5-c]pyridines as potent and orally-active metabotropic glutamate receptor 5 negative allosteric modulators.EBI
Bioorg Med Chem Lett 27: 4331-4335 (2017)
Sumitomo Dainippon Pharma
Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors.EBI
Bioorg Med Chem Lett 27: 4350-4353 (2017)
University Of Michigan
Quinazoline-1-deoxynojirimycin hybrids as high active dual inhibitors of EGFR and?-glucosidase.EBI
Bioorg Med Chem Lett 27: 4309-4313 (2017)
Key Laboratory Of The Ministry Of Education For Medicinal Resources And Natural Pharmaceutical Chemistry
Development of GLUT4-selective antagonists for multiple myeloma therapy.EBI
Eur J Med Chem 139: 573-586 (2017)
Emory University
Discovery of BAZ2A bromodomain ligands.EBI
Eur J Med Chem 139: 564-572 (2017)
University Of Z£Rich
Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.BDB
ACS Chem Biol 12: 2399-2407 (2017)
University Of Delaware
1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-EBI
ACS Med Chem Lett 8: 886-891 (2017)
University Of Washington
Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity.EBI
ACS Med Chem Lett 8: 875-880 (2017)
Fudan University
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.EBI
ACS Med Chem Lett 8: 869-874 (2017)
Celgene Quanticel Research
Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.EBI
ACS Med Chem Lett 8: 864-868 (2017)
University Of Pennsylvania
Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile.EBI
ACS Med Chem Lett 8: 858-863 (2017)
Universit£
Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains.EBI
ACS Med Chem Lett 8: 847-852 (2017)
Forma Therapeutics
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.EBI
ACS Med Chem Lett 8: 841-846 (2017)
Wuxi Apptec (Shanghai)
Discovery of Potent and Selective AEBI
ACS Med Chem Lett 8: 835-840 (2017)
Advinus Therapeutics
Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives.EBI
ACS Med Chem Lett 8: 830-834 (2017)
Chinese Academy Of Sciences
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors.EBI
ACS Med Chem Lett 8: 824-829 (2017)
University Of Illinois At Chicago
Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168).EBI
ACS Med Chem Lett 8: 808-813 (2017)
University Of Michigan
-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms.EBI
ACS Med Chem Lett 8: 792-796 (2017)
University Of Cagliari
CEBI
ACS Med Chem Lett 8: 786-788 (2017)
Temple University School Of Pharmacy
Inhibitors of CD73 May Provide a Treatment for Cancer and Autoimmune Diseases.EBI
ACS Med Chem Lett 8: 781-782 (2017)
Therachem Research Medilab (India)
Potential of PI3K? Inhibitors in the Treatment of Cancer and Other Diseases.EBI
ACS Med Chem Lett 8: 778-780 (2017)
Therachem Research Medilab (India)
Plasma Kallikrein Inhibitors for the Treatment of Retinal Vascular Permeability Associated with Diabetic Retinopathy and Diabetic Macular Edema.EBI
ACS Med Chem Lett 8: 776-777 (2017)
Therachem Research Medilab (India)
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-?-chloro-2'-?-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.EBI
Bioorg Med Chem Lett 27: 4323-4330 (2017)
Idenix An Msd
Meroterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. Marine Sponge.EBI
J Nat Prod 80: 2509-2514 (2017)
Shenyang Pharmaceutical University
Design, Synthesis, and Biological Evaluation of Novel Type IEBI
J Med Chem 60: 8027-8054 (2017)
Eberhard-Karls-Universitaet Tuebingen
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.EBI
Bioorg Med Chem Lett 27: 4370-4376 (2017)
Genentech
Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.EBI
Eur J Med Chem 139: 531-541 (2017)
Hebei Medical University
5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.EBI
J Med Chem 60: 7524-7538 (2017)
University Of Basel
Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics.EBI
Bioorg Med Chem Lett 27: 4221-4228 (2017)
Universidade De Santiago De Compostela
Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.EBI
Bioorg Med Chem Lett 27: 4399-4404 (2017)
Korea Research Institute Of Chemical Technology
An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics.EBI
Eur J Med Chem 139: 519-530 (2017)
University Of Calabria
Novel methyl indolinone-6-carboxylates containing an indole moiety as angiokinase inhibitors.EBI
Eur J Med Chem 139: 492-502 (2017)
Shenyang Pharmaceutical University
Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling.EBI
Eur J Med Chem 139: 482-491 (2017)
University Of Warwick
Highly Potent and Selective New Diphenethylamines Interacting with the?-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships.EBI
J Med Chem 60: 7579-7590 (2017)
University Of Innsbruck
Antagonists of Orexin Receptors as Potential Treatment of Sleep Disorders, Obesity, Eating Disorders, and Other Neurological and Psychiatric Disorders.EBI
ACS Med Chem Lett 7: 876-877 (2016)
Therachem Research Medilab (India)
Treatment of Metabolic Disorders with CB-1 Receptor Inverse Agonists.EBI
ACS Med Chem Lett 7: 874-875 (2016)
Therachem Research Medilab (India)
An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.EBI
Eur J Med Chem 139: 461-481 (2017)
Universidad Nacional De San Luis
Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts.EBI
J Med Chem 61: 1767-1773 (2018)
Merck
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.EBI
J Med Chem 60: 7244-7255 (2017)
Emory Chemical Biology Discovery Center Emory University School Of Medicine Atlanta
Recent advances of pyrazole-containing derivatives as anti-tubercular agents.EBI
Eur J Med Chem 139: 429-440 (2017)
Wuhan University Of Science And Technology
Design, synthesis and in vivo study of novel pyrrolidine-based 11?-HSD1 inhibitors for age-related cognitive dysfunction.EBI
Eur J Med Chem 139: 412-428 (2017)
Universitat De Barcelona
Discovery of non-zwitterionic aryl sulfonamides as NaEBI
Bioorg Med Chem 25: 5490-5505 (2017)
Bristol-Myers Squibb Research And Development
Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis.EBI
Bioorg Med Chem 26: 945-956 (2018)
Nestl�
Rational design, synthesis and preliminary antitumor activity evaluation of a chlorambucil derivative with potent DNA/HDAC dual-targeting inhibitory activity.EBI
Bioorg Med Chem Lett 27: 4415-4420 (2017)
Beijing University Of Chemical Technology
Characterization of a highly selective inhibitor of the Aurora kinases.EBI
Bioorg Med Chem Lett 27: 4405-4408 (2017)
Harvard Medical School
Identification of a New Zinc Binding Chemotype by Fragment Screening.EBI
J Med Chem 60: 7333-7349 (2017)
Griffith University
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.EBI
J Med Chem 60: 7764-7780 (2017)
Pfizer
Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.EBI
J Nat Prod 80: 2453-2461 (2017)
Chiba University
Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.EBI
J Med Chem 60: 7569-7578 (2017)
Ulsan National Institutes Of Science And Technology (Unist)
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.EBI
Eur J Med Chem 142: 229-243 (2017)
Pak Research Center
Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.EBI
J Med Chem 60: 8103-8114 (2017)
University Of Minnesota
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.EBI
J Med Chem 60: 7539-7554 (2017)
The Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences
DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health.EBI
J Nat Prod 80: 2284-2294 (2017)
Hallertauer Hopfenveredelung
A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3).EBI
Bioorg Med Chem Lett 27: 4440-4445 (2017)
Virginia Commonwealth University
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors.EBI
Bioorg Med Chem Lett 27: 4421-4425 (2017)
University Of Ferrara
Structure-function studies of BPP-BrachyNHEBI
Eur J Med Chem 139: 401-411 (2017)
Universidade Federal Do Piau£
Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.EBI
Eur J Med Chem 139: 378-389 (2017)
Alma Mater Studiorum-University Of Bologna
Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation.EBI
Eur J Med Chem 139: 367-377 (2017)
Technology And Research University-Vfstru (Vignan's University)
Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-?-lactamase-1.EBI
J Med Chem 60: 7267-7283 (2017)
University Of California San Diego
Triple reuptake inhibitors: Design, synthesis and structure-activity relationship of benzylpiperidine-tetrazoles.EBI
Bioorg Med Chem 25: 5278-5289 (2017)
Chonnam National University
Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide.EBI
Bioorg Med Chem 25: 5203-5215 (2017)
Taisho Pharmaceutical
Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine AEBI
J Med Chem 60: 7555-7568 (2017)
Leiden University
Indole-fused azepines and analogues as anticancer lead molecules: Privileged findings and future directions.EBI
Eur J Med Chem 142: 244-265 (2017)
Babasaheb Bhimrao Ambedkar University
Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies.EBI
Eur J Med Chem 139: 325-336 (2017)
University Of Minnesota
Discovery of novel 3-(hydroxyalkoxy)-2-alkylchromen-4-one analogs as interleukin-5 inhibitors.EBI
Eur J Med Chem 139: 290-304 (2017)
Chungnam National University
New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.EBI
Eur J Med Chem 139: 280-289 (2017)
Tehran University Of Medical Sciences
Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, inávitro biological evaluation, molecular docking and in silico ADME-T studies.EBI
Eur J Med Chem 139: 263-279 (2017)
King Abdulaziz University
1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy.EBI
Bioorg Med Chem Lett 27: 4482-4487 (2017)
Shanghai Institute Of Pharmaceutical Industry
Discovery of potent and selective CDK8 inhibitors through FBDD approach.EBI
Bioorg Med Chem Lett 27: 4488-4492 (2017)
Roche Innovation Center Shanghai
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.EBI
Bioorg Med Chem Lett 27: 4500-4505 (2017)
H. Lundbeck
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies.EBI
Eur J Med Chem 139: 250-262 (2017)
Kafrelsheikh University
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.EBI
Eur J Med Chem 139: 232-241 (2017)
University Of Ljubljana
Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase.EBI
Eur J Med Chem 139: 222-231 (2017)
Martin-Luther University Halle-Wittenberg
Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives.EBI
Eur J Med Chem 139: 214-221 (2017)
Chinese Academy Of Sciences
Discovery of pentacyclic triterpene 3?-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.EBI
Eur J Med Chem 139: 201-213 (2017)
China Pharmaceutical University
Pyrrolo[2,1-f][1,2,4]triazines: From C-nucleosides to kinases and back again, the remarkable journey of a versatile nitrogen heterocycle.EBI
Bioorg Med Chem Lett 27: 4238-4246 (2017)
Teva Global R&D
Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists.EBI
Bioorg Med Chem 25: 5327-5340 (2017)
Glaxosmithkline
Design, synthesis, and biological evaluation of novel 3-substituted imidazo[1,2-a]pyridine and quinazolin-4(3H)-one derivatives as PI3K? inhibitors.EBI
Eur J Med Chem 139: 95-106 (2017)
Shenyang Pharmaceutical University
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI
Eur J Med Chem 139: 68-83 (2017)
China Pharmaceutical University
Quinoline hybrids and their antiplasmodial and antimalarial activities.EBI
Eur J Med Chem 139: 22-47 (2017)
Hubei Engineering University
Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents.EBI
Eur J Med Chem 139: 153-167 (2017)
Universit£
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.EBI
Eur J Med Chem 139: 128-152 (2017)
China Pharmaceutical University
Identification of 3,4-dihydro-2H-thiochromene 1,1-dioxide derivatives with a phenoxyethylamine group as highly potent and selective ?EBI
Eur J Med Chem 139: 114-127 (2017)
Takeda Pharmaceutical
Fragment-Based Drug Discovery of Phosphodiesterase Inhibitors.EBI
J Med Chem 61: 1415-1424 (2018)
Iota Pharmaceuticals
Polypharmacology of NEBI
J Med Chem 60: 7459-7475 (2017)
Sahmyook University
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.EBI
Eur J Med Chem 139: 60-67 (2017)
Alma Mater Studiorum-University Of Bologna
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 139: 48-59 (2017)
Shanghai University Of Traditional Chinese Medicine
Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors.EBI
Eur J Med Chem 139: 1-11 (2017)
Universidade De Vigo
Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae.EBI
Bioorg Med Chem Lett 27: 4007-4010 (2017)
Griffith University
Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.EBI
Bioorg Med Chem 25: 5268-5277 (2017)
East China University Of Science & Technology
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine HEBI
Bioorg Med Chem 25: 5341-5354 (2017)
Jagiellonian University Medical College
Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity.EBI
Bioorg Med Chem 25: 5365-5372 (2017)
Universit£T M£Nster
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.EBI
J Med Chem 60: 7677-7702 (2017)
Takeda Pharmaceutical
Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide.BDB
ACS Chem Biol 12: 2264-2269 (2017)
Novartis Pharma
Identification and Characterization of the First Selective YEBI
J Med Chem 60: 7605-7612 (2017)
Leipzig University
Structural Basis of Analog Specificity in PKG I and II.BDB
ACS Chem Biol 12: 2388-2398 (2017)
Baylor College Of Medicine
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.EBI
J Med Chem 60: 7863-7875 (2017)
Moffitt Cancer Center
Effect of Nitrogen Atom Substitution in AEBI
J Med Chem 60: 7502-7511 (2017)
Uppsala University
Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution.EBI
J Med Chem 60: 7410-7424 (2017)
Research Triangle Institute
Facile alkylation of 4-nitrobenzotriazole and its platelet aggregation inhibitory activity.EBI
Bioorg Med Chem 25: 5260-5267 (2017)
Punjabi University
Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.EBI
Bioorg Med Chem 25: 5373-5379 (2017)
Universit£
Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities.EBI
Bioorg Med Chem 25: 5396-5406 (2017)
P.D. Patel Institute Of Applied Sciences
Imidazo[1,2-?]pyridines possess adenosine AEBI
Bioorg Med Chem Lett 27: 3963-3967 (2017)
North-West University
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.EBI
J Med Chem 60: 7447-7458 (2017)
Universit£
Discovery of novel pyrazolo[1,5-a]pyridine-based EPEBI
Bioorg Med Chem Lett 27: 4044-4050 (2017)
Kyorin Pharmaceutical
Targeting Eph/ephrin system in cancer therapy.EBI
Eur J Med Chem 142: 152-162 (2017)
University Of Parma
Macrocyclic factor XIa inhibitors.EBI
Bioorg Med Chem Lett 27: 4056-4060 (2017)
Bristol-Myers Squibb
Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors.EBI
Bioorg Med Chem Lett 27: 4015-4018 (2017)
Shanghai Jiao Tong University
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.EBI
J Med Chem 60: 7146-7165 (2017)
Northwestern University
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.EBI
Bioorg Med Chem 25: 4904-4916 (2017)
Xinjiang Technical Institute Of Physics And Chemistry
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.EBI
Bioorg Med Chem Lett 27: 4034-4038 (2017)
Neurodegeneration Dpu
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects.EBI
Eur J Med Chem 138: 1158-1169 (2017)
China Pharmaceutical University
Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors.EBI
Eur J Med Chem 138: 1147-1157 (2017)
Roche Innovation Center Shanghai
Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD).EBI
J Med Chem 61: 1745-1766 (2018)
Universit£
Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.EBI
J Med Chem 60: 7434-7446 (2017)
University Of Copenhagen
Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models.EBI
J Med Chem 60: 7099-7107 (2017)
Novartis Institutes For Biomedical Research
Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies.EBI
J Med Chem 61: 422-443 (2018)
Progenra
Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.EBI
Bioorg Med Chem Lett 27: 4051-4055 (2017)
Sichuan University And Collaborative Innovation Center
Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel?EBI
Bioorg Med Chem 25: 4778-4799 (2017)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.EBI
Eur J Med Chem 138: 1135-1146 (2017)
Tsinghua University
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).EBI
J Med Chem 60: 6911-6923 (2017)
University Of Messina
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.EBI
J Med Chem 60: 7483-7501 (2017)
Jagiellonian University Medical College
Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors.EBI
Bioorg Med Chem 25: 4855-4875 (2017)
Zarqa University
Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design.EBI
Bioorg Med Chem 25: 4876-4886 (2017)
Takeda Pharmaceutical
Recent advances (2015-2016) in anticancer hybrids.EBI
Eur J Med Chem 142: 179-212 (2017)
University Of Kwazulu Natal
Structure-activity relations of rosmarinic acid derivatives for the amyloid ? aggregation inhibition and antioxidant properties.EBI
Eur J Med Chem 138: 1066-1075 (2017)
Muroran Institute Of Technology
Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe.EBI
Eur J Med Chem 138: 1053-1065 (2017)
University Of Toledo
An overview of benzo[b]thiophene-based medicinal chemistry.EBI
Eur J Med Chem 138: 1002-1033 (2017)
Jain University
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.EBI
J Med Chem 60: 7123-7138 (2017)
Abbvie Deutschland
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.EBI
J Med Chem 60: 7658-7676 (2017)
Takeda Pharmaceutical
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.EBI
J Med Chem 60: 7799-7809 (2017)
Academy Of Sciences Of The Czech Republic
Design, synthesis and bioactivities of Celecoxib analogues or derivatives.EBI
Bioorg Med Chem 25: 4887-4893 (2017)
Chongqing Normal University
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.EBI
Bioorg Med Chem Lett 27: 4082-4085 (2017)
University Of Arizona
Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5?-androst-17?-amide derivatives as dual 5?-reductase inhibitors and androgen receptor antagonists.EBI
Bioorg Med Chem Lett 27: 4212-4217 (2017)
China Pharmaceutical University
Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation.EBI
Eur J Med Chem 138: 979-992 (2017)
Southeast University
Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands.EBI
Eur J Med Chem 138: 964-978 (2017)
Universities Of Lille
Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor.EBI
Bioorg Med Chem 25: 4817-4828 (2017)
Daiichi Sankyo
Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.EBI
Eur J Med Chem 138: 942-951 (2017)
China Pharmaceutical University
How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors.EBI
Eur J Med Chem 142: 131-151 (2017)
Ain Shams University
Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.EBI
Bioorg Med Chem Lett 27: 4194-4198 (2017)
Shionogi
Anion inhibitors of the?-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis.EBI
Bioorg Med Chem 25: 4800-4804 (2017)
Cnr
Neuroactive Steroids. 2. 3?-Hydroxy-3?-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5?-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (?-Aminobutyric Acid)EBI
J Med Chem 60: 7810-7819 (2017)
Sage Therapeutics
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?EBI
J Med Chem 60: 7206-7212 (2017)
University Of Porto
Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study.EBI
J Nat Prod 80: 2276-2283 (2017)
Universit£
?-Geminal disubstituted pyrrolidine iminosugars and their C-4-fluoro analogues: Synthesis, glycosidase inhibition and molecular docking studies.EBI
Bioorg Med Chem 25: 5148-5159 (2017)
Savitribai Phule Pune University (Formerly University Of Pune)
Discovery of spiro[indole-3,2'-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP.EBI
Bioorg Med Chem 25: 4753-4767 (2017)
Takeda Pharmaceutical
Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease.EBI
Bioorg Med Chem Lett 27: 4180-4184 (2017)
Central South University
Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists.EBI
Eur J Med Chem 138: 900-908 (2017)
South Dakota State University
Nonacidic Farnesoid X Receptor Modulators.EBI
J Med Chem 60: 7199-7205 (2017)
Goethe-University Frankfurt
Bioactive Azaphilone Derivatives from the Fungus Talaromyces aculeatus.EBI
J Nat Prod 80: 2199-2203 (2017)
Hebei University
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease.EBI
J Med Chem 61: 619-637 (2018)
University Of Dundee
Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the Inside.EBI
J Med Chem 61: 47-61 (2018)
University Of Bologna
Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products.EBI
J Nat Prod 80: 2360-2370 (2017)
University Of The Philippines
Discovery of Potent Orally Active Protease-Activated Receptor 1 (PAR1) Antagonists Based on Andrographolide.EBI
J Med Chem 60: 7166-7185 (2017)
Shandong University
Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors.EBI
Bioorg Med Chem Lett 27: 4156-4164 (2017)
Chungnam National University
Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists.EBI
J Med Chem 60: 6548-6562 (2017)
Universit£
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.EBI
ACS Med Chem Lett 8: 771-774 (2017)
Bristol-Myers Squibb Research And Development
3-Hydroxykynurenine, a Tryptophan Metabolite Generated during the Infection, Is Active Against EBI
ACS Med Chem Lett 8: 757-761 (2017)
Universidad Nacional De C£Rdoba
Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification.EBI
ACS Med Chem Lett 8: 751-756 (2017)
Tokyo University Of Pharmacy And Life Sciences
GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).EBI
ACS Med Chem Lett 8: 737-741 (2017)
Genentech
Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.EBI
ACS Med Chem Lett 8: 732-736 (2017)
Takeda Pharmaceutical
Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.EBI
ACS Med Chem Lett 8: 726-731 (2017)
Sanford Burnham Prebys Medical Discovery Institute
Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound.EBI
ACS Med Chem Lett 8: 715-719 (2017)
Kao
Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.EBI
ACS Med Chem Lett 8: 694-700 (2017)
The Scripps Research Institute
Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors.EBI
Bioorg Med Chem 25: 4579-4594 (2017)
Fudan University
Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety.EBI
Bioorg Med Chem 25: 4701-4714 (2017)
Xinxiang Medical University
Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.EBI
Bioorg Med Chem Lett 27: 4176-4179 (2017)
University Of Tsukuba
Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.EBI
Bioorg Med Chem Lett 27: 4133-4139 (2017)
Georgia Institute Of Technology
Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors.EBI
Eur J Med Chem 138: 874-883 (2017)
Jagiellonian University Medical College
Inhibitory Kappa B Kinase? (IKK?) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers.EBI
J Med Chem 60: 7043-7066 (2017)
University Of Strathclyde
Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.EBI
Eur J Med Chem 138: 830-853 (2017)
Janssen Research And Development
Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors.EBI
Eur J Med Chem 138: 816-829 (2017)
Universit£T Rostock
Development of novel LP1-based analogues with enhanced delta opioid receptor profile.EBI
Bioorg Med Chem 25: 4745-4752 (2017)
University Of Catania
Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC.EBI
Bioorg Med Chem Lett 27: 4171-4175 (2017)
Sichuan University And Collaborative Innovation Center
Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.EBI
Eur J Med Chem 138: 774-806 (2017)
The Medical University Of Silesia
Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.EBI
J Med Chem 60: 7371-7392 (2017)
Galapagos
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.EBI
J Med Chem 61: 2133-2165 (2018)
Biocon Bristol-Myers Squibb R&D Centre
Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HTEBI
Bioorg Med Chem Lett 27: 4146-4149 (2017)
University Of Science And Technology
KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.EBI
Bioorg Med Chem 25: 4628-4636 (2017)
Universidad De La Habana
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.EBI
Bioorg Med Chem 25: 4560-4565 (2017)
Universita Degli Studi Di Firenze
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.EBI
Eur J Med Chem 138: 761-773 (2017)
Universidad De Sevilla
Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.EBI
Eur J Med Chem 138: 748-760 (2017)
National And Kapodistrian University Of Athens
Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.EBI
Eur J Med Chem 138: 738-747 (2017)
Central South University
Discovery of imidazopyridines containing isoindoline-1,3-dione framework as a new class of BACE1 inhibitors: Design, synthesis and SAR analysis.EBI
Eur J Med Chem 138: 729-737 (2017)
University Of Tehran
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-? aggregation for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 138: 715-728 (2017)
Shenyang Pharmaceutical University
Opioid Receptor Modulators with a Cinnamyl Group.EBI
J Med Chem 60: 6733-6750 (2017)
Alkem Laboratories
Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis.EBI
J Med Chem 60: 7067-7083 (2017)
East China Normal University
Mushroom-Derived Indole Alkaloids.EBI
J Nat Prod 80: 2178-2187 (2017)
University Of Auckland
Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.EBI
Bioorg Med Chem Lett 27: 3653-3660 (2017)
Nanjing University
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.EBI
Bioorg Med Chem Lett 27: 3939-3943 (2017)
Merck
Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects.EBI
Bioorg Med Chem 25: 4656-4664 (2017)
Kyung Hee University
Recent synthetic and medicinal perspectives of tryptanthrin.EBI
Bioorg Med Chem 25: 4533-4552 (2017)
Indo-Soviet Friendship College Of Pharmacy (Isfcp)
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPAR? and SUR agonists.EBI
Bioorg Med Chem 25: 4723-4744 (2017)
Al-Azhar University
Asymmetric synthesis and evaluation of epoxy-?-acyloxycarboxamides as selective inhibitors of cathepsin L.EBI
Bioorg Med Chem 25: 4620-4627 (2017)
Federal University Of S£O Carlos
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.EBI
Bioorg Med Chem 25: 4677-4685 (2017)
Korea University Of Science And Technology (Ust)
Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.BDB
ACS Chem Biol 12: 2240-2247 (2017)
Michigan State University
Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene.EBI
J Nat Prod 80: 2094-2100 (2017)
Istanbul Technical University
Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.EBI
Bioorg Med Chem 25: 4553-4559 (2017)
Tsinghua University-Peking University Joint Center For Life Sciences
Design, synthesis and biological evaluation of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydroquinoxaline moiety as c-Met kinase inhibitors.EBI
Bioorg Med Chem 25: 4475-4486 (2017)
Shenyang Pharmaceutical University
Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPSEBI
J Med Chem 60: 6384-6399 (2017)
The University Of Tokyo
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.EBI
J Med Chem 60: 6018-6035 (2017)
University Of Chinese Academy Of Sciences
Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.EBI
J Med Chem 60: 6924-6941 (2017)
Sun Yat-Sen University
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.EBI
J Med Chem 60: 6998-7011 (2017)
University College London
Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine.EBI
Bioorg Med Chem 25: 5128-5132 (2017)
Purdue University
Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3? inhibitors.EBI
Bioorg Med Chem Lett 27: 3726-3732 (2017)
Mitsubishi Tanabe Pharma
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3? inhibitors.EBI
Bioorg Med Chem Lett 27: 3733-3738 (2017)
Mitsubishi Tanabe Pharma
The Fragment Network: A Chemistry Recommendation Engine Built Using a Graph Database.EBI
J Med Chem 60: 6440-6450 (2017)
Astex Pharmaceuticals
Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells.EBI
Eur J Med Chem 138: 689-697 (2017)
Shaanxi Normal University
Development of a series of novel 4-anlinoquinazoline derivatives possessing quinazoline skeleton: Design, synthesis, EGFR kinase inhibitory efficacy, and evaluation of anticancer activities inávitro.EBI
Eur J Med Chem 138: 669-688 (2017)
Beijing Normal University
Development of a prodrug of hydantoin based TACE inhibitor.EBI
Bioorg Med Chem Lett 27: 3704-3708 (2017)
Merck
Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy.EBI
Bioorg Med Chem Lett 27: 3766-3771 (2017)
Rigel Pharmaceuticals
Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance.EBI
Bioorg Med Chem Lett 27: 3683-3687 (2017)
De Montfort University
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).EBI
Eur J Med Chem 138: 661-668 (2017)
Thomas Jefferson University
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification.EBI
Eur J Med Chem 138: 644-660 (2017)
Universidad De Sevilla
Design, synthesis, biological evaluation and molecular modelling studies of novel diaryl substituted pyrazolyl thiazolidinediones as potent pancreatic lipase inhibitors.EBI
Bioorg Med Chem Lett 27: 3749-3754 (2017)
Birla Institute Of Technology
Novel pyrazolopyrimidines: Synthesis, inávitro cytotoxic activity and mechanistic investigation.EBI
Eur J Med Chem 138: 565-576 (2017)
Cairo University
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.EBI
Eur J Med Chem 138: 552-564 (2017)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity.EBI
Eur J Med Chem 138: 543-551 (2017)
Shandong University
Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2.EBI
J Med Chem 60: 6704-6720 (2017)
Leiden University
Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.EBI
J Nat Prod 80: 1955-1963 (2017)
Unidad De Gen�Mica Avanzada (Langebio)
Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease.EBI
J Med Chem 60: 6664-6677 (2017)
Shenzhen University
Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.EBI
J Med Chem 60: 6991-6997 (2017)
University Of Copenhagen
Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure.EBI
J Med Chem 60: 6942-6990 (2017)
Takeda Pharmaceutical
Bistacrines as potential antitrypanosomal agents.EBI
Bioorg Med Chem 25: 4526-4531 (2017)
Julius-Maximilians-University Of W£Rzburg
Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor.EBI
Bioorg Med Chem 25: 4506-4511 (2017)
Osaka University
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.EBI
J Med Chem 60: 6721-6732 (2017)
University Of California
Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.EBI
J Med Chem 60: 6451-6457 (2017)
Pfizer
Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from?-Santonin Derivatives.EBI
J Med Chem 60: 6828-6852 (2017)
Second Military Medical University
Discovery of a Benzamide Derivative That Protects Pancreatic?-Cells against Endoplasmic Reticulum Stress.EBI
J Med Chem 60: 6191-6204 (2017)
Oklahoma Medical Research Foundation
Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.EBI
Bioorg Med Chem Lett 27: 3812-3816 (2017)
China Medical University
Tuning of ?-glucosidase and ?-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules.EBI
Eur J Med Chem 138: 532-542 (2017)
University Of Seville
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced inávivo efficacy for cancer therapy.EBI
Eur J Med Chem 138: 514-531 (2017)
East China University Of Science And Technology
Triazole derivatives and their anti-tubercular activity.EBI
Eur J Med Chem 138: 501-513 (2017)
Wuhan University Of Science And Technology
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.EBI
J Med Chem 61: 583-598 (2018)
Arvinas
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.EBI
J Med Chem 60: 6337-6352 (2017)
Sichuan University And Collaborative Innovation Center For Biotherapy
Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.EBI
J Nat Prod 80: 2077-2087 (2017)
Universit£
Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.EBI
Bioorg Med Chem 25: 4512-4525 (2017)
Novartis Institutes For Biomedical Research
The medicinal chemistry of Chikungunya virus.EBI
Bioorg Med Chem 25: 4219-4244 (2017)
Federal University Of Alagoas
Selective inhibitors of human mPGES-1 from structure-based computational screening.EBI
Bioorg Med Chem Lett 27: 3739-3743 (2017)
University Of Kentucky
Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.EBI
Eur J Med Chem 138: 458-479 (2017)
China Pharmaceutical University
First dual AK/GSK-3? inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.EBI
Eur J Med Chem 138: 438-457 (2017)
Universit£
Discovery of highly selective?-opioid receptor agonists: 10?-Hydroxy TRK-820 derivatives.EBI
Bioorg Med Chem Lett 27: 3920-3924 (2017)
Toray Industries
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector.EBI
Eur J Med Chem 138: 407-421 (2017)
Emory University
Synthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors.EBI
Eur J Med Chem 138: 396-406 (2017)
University Of The Punjab
Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues.EBI
Eur J Med Chem 138: 371-383 (2017)
Universit£
Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.EBI
Eur J Med Chem 138: 343-352 (2017)
Peking University Health Science Center
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents.EBI
Eur J Med Chem 138: 328-342 (2017)
Centro De Investigaciones Biol�Gicas-Csic
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.EBI
Bioorg Med Chem Lett 27: 3897-3904 (2017)
Karolinska Institutet
Oxindole-based intraocular pressure reducing agents.EBI
Bioorg Med Chem Lett 27: 3787-3793 (2017)
Lomonosov Moscow State University
Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors.EBI
Bioorg Med Chem Lett 27: 3782-3786 (2017)
Fudan University
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.EBI
Bioorg Med Chem Lett 27: 3833-3839 (2017)
Bristol-Myers Squibb
Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors.EBI
Eur J Med Chem 138: 320-327 (2017)
Kyoto University
Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension.EBI
J Med Chem 60: 6622-6637 (2017)
Sun Yat-Sen University
Identification of Peptidic Antagonists of Vascular Endothelial Growth Factor Receptor 1 by Scanning the Binding Epitopes of Its Ligands.EBI
J Med Chem 60: 6598-6606 (2017)
Umr 8638 Cnrs
Synthetic Modification within the"RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.EBI
J Med Chem 60: 6408-6427 (2017)
University Of Alberta
Potent antiobesity effect of a short-length peptide YY-analogue continuously administered in mice.EBI
Bioorg Med Chem Lett 27: 3829-3832 (2017)
Takeda Pharmaceutical
Discovery of a biarylamide series of potent, state-dependent NaEBI
Bioorg Med Chem Lett 27: 3817-3824 (2017)
Amgen
Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase.EBI
Bioorg Med Chem 25: 4497-4505 (2017)
Fourth Military Medical University
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaEBI
J Med Chem 60: 7029-7042 (2017)
Icagen
Synthesis of novel 2-pyrazoline analogues with potent anti-inflammatory effect mediated by inhibition of phospholipase A2: Crystallographic, in silico docking and QSAR analysis.EBI
Bioorg Med Chem Lett 27: 3806-3811 (2017)
University Of Mysore
Substituted?-mercaptoketones, new types of specific neprilysin inhibitors.EBI
Bioorg Med Chem Lett 27: 3883-3890 (2017)
Pharmaleads
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.EBI
Eur J Med Chem 138: 273-292 (2017)
Csir - Indian Institute Of Integrative Medicine
Design, synthesis and biological evaluation of GPR55 agonists.EBI
Bioorg Med Chem 25: 4355-4367 (2017)
University Of North Carolina At Greensboro
Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.EBI
J Med Chem 60: 6137-6151 (2017)
Janssen Pharmaceutica
Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.EBI
J Med Chem 60: 6563-6586 (2017)
Universit£
Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.EBI
J Med Chem 60: 6678-6692 (2017)
Experimental Therapeutics Centre
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.EBI
Bioorg Med Chem 25: 4424-4432 (2017)
Banaras Hindu University
Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.EBI
Bioorg Med Chem Lett 27: 3878-3882 (2017)
University Of Leeds
Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists.EBI
Bioorg Med Chem 25: 4314-4329 (2017)
Latvian Institute Of Organic Synthesis
Diaminopimelic acid (DAP) analogs bearing isoxazoline moiety as selective inhibitors against meso-diaminopimelate dehydrogenase (m-Ddh) from Porphyromonas gingivalis.EBI
Bioorg Med Chem Lett 27: 3840-3844 (2017)
Virginia Commonwealth University
A novel structural class of coumarin-chalcone fibrates as PPAR?/? agonists with potent antioxidant activities: Design, synthesis, biological evaluation and molecular docking studies.EBI
Eur J Med Chem 138: 212-220 (2017)
Shenyang Pharmaceutical University
Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches.EBI
Eur J Med Chem 138: 199-211 (2017)
China Pharmaceutical University
Recent developments in biological activities of indanones.EBI
Eur J Med Chem 138: 182-198 (2017)
Jain University
Potent haloperidol derivatives covalently binding to the dopamine D2 receptor.EBI
Bioorg Med Chem 25: 5084-5094 (2017)
Friedrich-Alexander University Erlangen-N£Rnberg
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.EBI
Bioorg Med Chem Lett 27: 3909-3914 (2017)
Korea Research Institute Of Chemical Technology
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.EBI
J Med Chem 60: 6516-6527 (2017)
Principia Biopharma
Antitrichomonal activity of? opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.EBI
Bioorg Med Chem 25: 4375-4383 (2017)
University Of Tsukuba
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.EBI
Bioorg Med Chem 25: 4259-4264 (2017)
Riken Center For Life Science Technologies
Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.EBI
Bioorg Med Chem 25: 4414-4423 (2017)
Icahn School Of Medicine At Mount Sinai
Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships.EBI
Bioorg Med Chem 25: 4339-4354 (2017)
Taisho Pharmaceutical
Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents.EBI
Bioorg Med Chem Lett 27: 3931-3938 (2017)
Senomyx
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.EBI
J Med Chem 60: 6428-6439 (2017)
Universit£
Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.EBI
J Med Chem 60: 6273-6288 (2017)
University Of Illinois At Chicago
Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.EBI
J Med Chem 60: 6321-6336 (2017)
The Scripps Research Institute
Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide.EBI
J Med Chem 60: 6089-6097 (2017)
Takeda Pharmaceutical
Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization.EBI
J Med Chem 60: 6249-6272 (2017)
University Of Nantes
Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.EBI
J Med Chem 60: 5364-5376 (2017)
Purdue University
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.EBI
Bioorg Med Chem Lett 27: 3219-3225 (2017)
Karolinska Institutet
Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.EBI
Bioorg Med Chem Lett 27: 3602-3606 (2017)
Guangxi Medical University
Polyphenolic Phytochemicals in Cancer Prevention and Therapy: Bioavailability versus Bioefficacy.EBI
J Med Chem 60: 9413-9436 (2017)
University Of Valencia
Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.EBI
J Med Chem 60: 5816-5825 (2017)
Scripps Florida
Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8).EBI
J Med Chem 60: 8691-8705 (2017)
Celgene
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.EBI
J Med Chem 60: 6036-6044 (2017)
Heinrich-Heine-Universit£T D£Sseldorf
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.EBI
Bioorg Med Chem Lett 27: 3243-3248 (2017)
Viamet Pharmaceuticals
Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.EBI
Bioorg Med Chem Lett 27: 3607-3610 (2017)
University Of Namur
Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate.EBI
Bioorg Med Chem Lett 27: 3231-3237 (2017)
Nankai University
Novel analogs of N-acylhydroxyethylaminomethyl-4H-chromen-4-one scaffold as IL-5 inhibitors.EBI
Bioorg Med Chem 25: 4330-4338 (2017)
Chungnam National University
Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies.EBI
Eur J Med Chem 137: 598-611 (2017)
Zhejiang University
Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.EBI
J Med Chem 60: 6289-6304 (2017)
Shandong University
Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.EBI
J Med Chem 60: 6305-6320 (2017)
Universit£
Optimization of a novel series of potent and orally bioavailable GPR119 agonists.EBI
Bioorg Med Chem Lett 27: 3249-3253 (2017)
Kowa
Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.EBI
Bioorg Med Chem Lett 27: 3289-3293 (2017)
The Scripps Research Institute
The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity.EBI
Bioorg Med Chem Lett 27: 3254-3258 (2017)
Wayne State University
Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors.EBI
Bioorg Med Chem 25: 4194-4202 (2017)
China Pharmaceutical University
Thiophene/thiazole-benzene replacement on guanidine derivatives targeting?EBI
Eur J Med Chem 138: 38-50 (2017)
Trinity College
Designing novel inhibitors against histone acetyltransferase (HAT:áGCN5) of Plasmodium falciparum.EBI
Eur J Med Chem 138: 26-37 (2017)
Jawaharlal Nehru University
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.EBI
Bioorg Med Chem Lett 27: 3272-3278 (2017)
Janssen Research And Development
Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships.EBI
Bioorg Med Chem Lett 27: 3382-3385 (2017)
Dalian University Of Technology
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.EBI
Bioorg Med Chem 25: 4175-4193 (2017)
Scohia Pharma
Synthesis of 8-Substituted Analogues of Cyclic ADP-4-Thioribose and Their Unexpected Identification as CaEBI
J Med Chem 60: 5868-5875 (2017)
Juntendo University School Of Medicine
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.EBI
J Med Chem 60: 6364-6383 (2017)
National Institute Of Diabetes And Digestive And Kidney Diseases
Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HTEBI
J Med Chem 60: 6166-6190 (2017)
Bristol-Myers Squibb
1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities.EBI
Bioorg Med Chem 25: 4064-4075 (2017)
P.D. Patel Institute Of Applied Sciences
Synthesis and biological activity of peptide proline-boronic acids as proteasome inhibitors.EBI
Bioorg Med Chem 25: 4031-4044 (2017)
Peking University
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.EBI
Bioorg Med Chem Lett 27: 3294-3300 (2017)
Bristol-Myers Squibb Research And Development
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.EBI
Bioorg Med Chem Lett 27: 3576-3581 (2017)
Vanderbilt University School Of Medicine
Design, synthesis and biological evaluation of novel 3H-imidazole [4,5-b] pyridine derivatives as selective mTOR inhibitors.EBI
Bioorg Med Chem Lett 27: 3395-3398 (2017)
China Pharmaceutical University
Design, synthesis and tumor cell growth inhibitory activity of 3-nitro-2H-cheromene derivatives as histone deacetylaes inhibitors.EBI
Bioorg Med Chem 25: 4123-4132 (2017)
Shandong University
A novel intestinal-restricted FXR agonist.EBI
Bioorg Med Chem Lett 27: 3386-3390 (2017)
China Pharmaceutical University
The discovery of benzoxazine sulfonamide inhibitors of NaEBI
Bioorg Med Chem Lett 27: 3477-3485 (2017)
Amgen
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors.EBI
Eur J Med Chem 137: 545-557 (2017)
University Of Science And Technology Of China
Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.EBI
J Med Chem 60: 6528-6547 (2017)
Sapienza University Of Rome
Development of Quinazoline/Pyrimidine-2,4(1EBI
ACS Med Chem Lett 8: 678-681 (2017)
Zhejiang University
Discovery of a Series of Indazole TRPA1 Antagonists.EBI
ACS Med Chem Lett 8: 666-671 (2017)
Pfizer
Photoaffinity Labeling of the Human AEBI
ACS Med Chem Lett 8: 660-665 (2017)
Kissei Pharmaceutical
Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.EBI
ACS Med Chem Lett 8: 654-659 (2017)
University Of Notre Dame
Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands.EBI
ACS Med Chem Lett 8: 648-653 (2017)
Freie Universit£T Berlin
F-NMR-Based Dual-Site Reporter Assay for the Discovery and Distinction of Catalytic and Allosteric Kinase Inhibitors.EBI
ACS Med Chem Lett 8: 632-635 (2017)
Novartis Institutes For Biomedical Research
Antiobesity Effect of a Short-Length Peptide YY Analogue after Continuous Administration in Mice.EBI
ACS Med Chem Lett 8: 628-631 (2017)
Takeda Pharmaceutical
Study ofEBI
ACS Med Chem Lett 8: 622-627 (2017)
The Ohio State University
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.EBI
ACS Med Chem Lett 8: 618-621 (2017)
Yale University
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules.EBI
ACS Med Chem Lett 8: 614-617 (2017)
Yale University
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.EBI
ACS Med Chem Lett 8: 608-613 (2017)
Genentech
Janus-Associated Kinase 1 (JAK1) Inhibitors as Potential Treatment for Immune Disorders.EBI
ACS Med Chem Lett 8: 598-600 (2017)
Therachem Research Medilab (India)
Inhibitors of Adaptor-Associated Kinase 1 (AAK1) May Treat Neuropathic Pain, Schizophrenia, Parkinson's Disease, and Other Disorders.EBI
ACS Med Chem Lett 8: 595-597 (2017)
Therachem Research Medilab (India)
Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.EBI
Bioorg Med Chem 25: 4145-4152 (2017)
Seoul National University
Evaluation of the antidepressant therapeutic potential of isocyanine and pseudoisocyanine analogues of the organic cation decynium-22.EBI
Eur J Med Chem 137: 476-487 (2017)
The Australian Nuclear Science And Technology Organisation
2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation andádocking studies.EBI
Eur J Med Chem 137: 462-475 (2017)
Peking University Health Science Center
A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b.EBI
Bioorg Med Chem Lett 27: 3349-3352 (2017)
Leipzig University
Anti-diabetic xanthones from the bark of Garcinia xanthochymus.EBI
Bioorg Med Chem Lett 27: 3301-3304 (2017)
Vnuhcm-University Of Science
Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors.EBI
Bioorg Med Chem 25: 4045-4054 (2017)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.EBI
Bioorg Med Chem 25: 4153-4162 (2017)
Takeda Pharmaceutical
Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.EBI
J Nat Prod 80: 1992-2000 (2017)
University Of Iowa
Sulawesins A-C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a Psammocinia sp. Marine Sponge.EBI
J Nat Prod 80: 2045-2050 (2017)
Kumamoto University
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.EBI
J Med Chem 60: 5717-5735 (2017)
Novartis Pharma
Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine.EBI
Bioorg Med Chem Lett 27: 3511-3515 (2017)
Fudan University
Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides.EBI
Bioorg Med Chem 25: 4133-4144 (2017)
Kyoto University
Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives.EBI
Eur J Med Chem 142: 74-86 (2017)
Universit£
Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-?-lactamase inhibitor.EBI
Eur J Med Chem 137: 351-364 (2017)
The University Of Queensland
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.EBI
J Med Chem 60: 5933-5939 (2017)
Eli Lilly
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38? MAPK/PDE-4 Inhibitor with Activity against TNF?-Related Diseases.EBI
J Med Chem 60: 5290-5305 (2017)
C-A-I-R Biosciences
Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.EBI
J Med Chem 60: 5857-5867 (2017)
Jagiellonian University
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a"Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.EBI
J Med Chem 60: 5909-5926 (2017)
Vfp Therapies
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).EBI
Bioorg Med Chem Lett 27: 3317-3325 (2017)
Abbvie
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol.EBI
Bioorg Med Chem Lett 27: 3332-3336 (2017)
University Of Siena
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.EBI
Bioorg Med Chem Lett 27: 3378-3381 (2017)
Zhejiang Ocean University Engineering Technology Research Center Of Marine Biomedical Products
3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors.EBI
Bioorg Med Chem Lett 27: 3521-3528 (2017)
Zhengzhou University
Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists.EBI
Bioorg Med Chem Lett 27: 3408-3411 (2017)
Kyoto University
Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.EBI
Bioorg Med Chem Lett 27: 3353-3358 (2017)
Pfizer
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.EBI
Eur J Med Chem 137: 327-337 (2017)
Universit£
Anti-diabetic activity of fused PPAR?-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.EBI
Eur J Med Chem 137: 310-326 (2017)
University Of Lille
Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.EBI
J Med Chem 60: 5599-5612 (2017)
National Health Research Institutes
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies.EBI
J Med Chem 60: 9913-9931 (2017)
Universit£
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.EBI
Bioorg Med Chem Lett 27: 3207-3218 (2017)
Amgen
Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.EBI
Eur J Med Chem 137: 280-291 (2017)
Tianjin University Of Technology
Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.EBI
J Med Chem 60: 5613-5637 (2017)
Eberhard Karls University T£Bingen
a-Conotoxin [S9A]TxID Potently Discriminates betweena3▀4 anda6/a3▀4 Nicotinic Acetylcholine Receptors.EBI
J Med Chem 60: 5826-5833 (2017)
Hainan University
Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.EBI
J Med Chem 60: 5800-5815 (2017)
Istituto Italiano Di Tecnologia
Design and synthesis of novel? opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration.EBI
Bioorg Med Chem Lett 27: 3495-3498 (2017)
Nippon Chemiphar
Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides.EBI
Bioorg Med Chem 25: 4076-4087 (2017)
Cardiff University
Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.EBI
Bioorg Med Chem 25: 4008-4030 (2017)
The Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy.EBI
Bioorg Med Chem 25: 4100-4109 (2017)
Tsinghua University
Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.EBI
Bioorg Med Chem 25: 3947-3963 (2017)
Bioleap
Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition.EBI
Bioorg Med Chem 25: 4110-4122 (2017)
Astellas Pharma
A new type of pharmacological chaperone for GEBI
Bioorg Med Chem Lett 27: 3431-3435 (2017)
Graz University Of Technology
Design and Synthesis of?- and?-Lactam MEBI
J Med Chem 60: 6649-6663 (2017)
Pfizer
A potent and selective natriuretic peptide receptor-3 blocker 11-mer peptide created by hybridization of musclin and atrial natriuretic peptide.EBI
Bioorg Med Chem Lett 27: 3542-3545 (2017)
Takeda Pharmaceutical
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.EBI
J Med Chem 60: 5424-5437 (2017)
Emory University
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.EBI
J Med Chem 61: 504-513 (2018)
University Of Dundee
Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.EBI
J Med Chem 61: 543-575 (2018)
National Institute Of Health Sciences
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.EBI
J Med Chem 60: 5663-5672 (2017)
Takeda California
Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms.EBI
J Med Chem 60: 8268-8297 (2017)
Universit£
Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.EBI
J Med Chem 60: 5455-5471 (2017)
Glaxosmithkline
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the AEBI
J Med Chem 60: 5772-5790 (2017)
Universit£
Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.EBI
Bioorg Med Chem 25: 3980-3988 (2017)
Tehran University Of Medical Sciences
Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.EBI
J Med Chem 60: 8257-8267 (2017)
University Of Pavia
Insights on the Interaction between Transthyretin and A? in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.EBI
J Med Chem 60: 5749-5758 (2017)
Cic Biogune
Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor.EBI
Eur J Med Chem 137: 176-195 (2017)
Chinese Academy Of Sciences
The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.EBI
J Med Chem 60: 5556-5585 (2017)
Emory University
Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.EBI
J Med Chem 60: 5759-5771 (2017)
Takeda California
Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-? Motif Kinase (ZAK) Inhibitors.EBI
J Med Chem 60: 5927-5932 (2017)
University Of Macau
Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.EBI
Eur J Med Chem 137: 139-155 (2017)
University Of Auckland
Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines.EBI
J Med Chem 60: 5334-5348 (2017)
Heinrich-Heine-Universit£T D£Sseldorf
Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.EBI
Bioorg Med Chem Lett 27: 3558-3564 (2017)
K L University
Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554.EBI
Bioorg Med Chem Lett 27: 3565-3571 (2017)
Takeda Pharmaceutical
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.EBI
Bioorg Med Chem 25: 3997-4007 (2017)
Urals Branch Of Russian Academy Of Sciences
BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium.EBI
Bioorg Med Chem 25: 3964-3970 (2017)
Pukyong National University
Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity.EBI
Bioorg Med Chem 25: 3989-3996 (2017)
Dalian Medical University
Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor.EBI
Bioorg Med Chem Lett 27: 3167-3172 (2017)
Hyogo University Of Health Sciences
Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators.EBI
Eur J Med Chem 137: 63-75 (2017)
Amgen
Synthesis of a new series of aryl/heteroarylpiperazinyl derivatives of 8-acetyl-7-hydroxy-4-methylcoumarin with low nanomolar 5-HTEBI
Eur J Med Chem 137: 108-116 (2017)
Medical University Of Warsaw
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.EBI
J Med Chem 60: 5673-5698 (2017)
Pfizer
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.EBI
J Med Chem 60: 5493-5506 (2017)
Heinrich-Heine-Universit£T D£Sseldorf
Development of novel N-3-bromoisoxazolin-5-yl substituted 2,3-benzodiazepines as noncompetitive AMPAR antagonists.EBI
Bioorg Med Chem 25: 3631-3637 (2017)
University Of Messina
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents.EBI
Bioorg Med Chem 25: 3768-3779 (2017)
Takeda Pharmaceutical
Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3K?/mTOR inhibitors.EBI
Bioorg Med Chem Lett 27: 3117-3122 (2017)
Temple University
Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.EBI
J Med Chem 60: 5086-5098 (2017)
Saarland University
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.BDB
BMC Biochem 18: 1-15 (2017)
Concordia University Of Wisconsin
Development of WNK signaling inhibitors as a new class of antihypertensive drugs.EBI
Bioorg Med Chem 25: 3845-3852 (2017)
Tokyo Medical And Dental University (Tmdu)
Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.EBI
J Med Chem 60: 5209-5215 (2017)
Takeda California
Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.EBI
J Med Chem 60: 5377-5391 (2017)
German University In Cairo
Searching for novel NEBI
Bioorg Med Chem 25: 3861-3870 (2017)
Universit£
Halogen-substituted catechol bisphosphates are potent and selective inhibitors of the transcription factor STAT5b.EBI
Bioorg Med Chem 25: 3871-3882 (2017)
Leipzig University
Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.EBI
Bioorg Med Chem Lett 27: 3037-3042 (2017)
Merck
Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents.EBI
Eur J Med Chem 137: 96-107 (2017)
Shenyang Pharmaceutical University
Inhibition Potential of Cycloartane-Type Glycosides from the Roots of Cimicifuga dahurica against Soluble Epoxide Hydrolase.EBI
J Nat Prod 80: 1867-1875 (2017)
Chungnam National University
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.EBI
J Med Chem 60: 4869-4881 (2017)
Novartis Institutes For Biomedical Research
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.EBI
J Med Chem 60: 5146-5161 (2017)
Bayer
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.EBI
J Med Chem 60: 4949-4962 (2017)
University Of Kaiserslautern
Design, synthesis of novel furan appended benzothiazepine derivatives and in vitro biological evaluation as potent VRV-PL-8a and HEBI
Bioorg Med Chem Lett 27: 3048-3054 (2017)
University Of Mysore
Design and synthesis of potent HIV-1 protease inhibitors with (S)-tetrahydrofuran-tertiary amine-acetamide as P2-ligand: Structure-activity studies and biological evaluation.EBI
Eur J Med Chem 137: 30-44 (2017)
Chinese Academy Of Medical Science And Peking Union Medical College
One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE.EBI
Bioorg Med Chem Lett 27: 3071-3075 (2017)
Madurai Kamaraj University
Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.EBI
Bioorg Med Chem Lett 27: 3060-3064 (2017)
Korea Research Institute Of Bioscience And Biotechnology
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease.EBI
Bioorg Med Chem 25: 3815-3826 (2017)
China Pharmaceutical University
Synthesis and evaluation of novel dual BRD4/HDAC inhibitors.EBI
Bioorg Med Chem 25: 3677-3684 (2017)
The University Of Tokyo
Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.EBI
J Med Chem 60: 5002-5014 (2017)
Novartis Institutes For Biomedical Research
Subtly Modulating Glycogen Synthase Kinase 3?: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases.EBI
J Med Chem 60: 4983-5001 (2017)
Centro De Investigaciones Biol�Gicas-Csic
Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability.EBI
J Med Chem 60: 5228-5234 (2017)
Tokyo University Of Pharmacy And Life Sciences
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.EBI
Bioorg Med Chem Lett 27: 3190-3195 (2017)
University Of Manchester
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.EBI
Bioorg Med Chem 25: 3714-3718 (2017)
Istanbul University
Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase.EBI
Bioorg Med Chem 25: 3606-3613 (2017)
National Academy Of Sciences Of Ukraine
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase? (PI3K?) Inhibitor for the Treatment of Immunological Disorders.EBI
J Med Chem 60: 5193-5208 (2017)
Bristol-Myers Squibb
Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRa) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs).EBI
J Med Chem 60: 5099-5119 (2017)
East China University Of Science And Technology
Bioactive Glycosides from the Twigs of Litsea cubeba.EBI
J Nat Prod 80: 1808-1818 (2017)
Lanzhou University
Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo.EBI
J Med Chem 60: 5162-5192 (2017)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp.EBI
Bioorg Med Chem Lett 27: 3123-3126 (2017)
Ewha Womans University
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.EBI
Bioorg Med Chem Lett 27: 3101-3106 (2017)
Bristol-Myers Squibb Research And Development
Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors.EBI
Bioorg Med Chem Lett 27: 3201-3204 (2017)
Sichuan University
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor?/? (PPAR?/?) dual agonists.EBI
Bioorg Med Chem Lett 27: 3131-3134 (2017)
The University Of Tokyo
Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities.EBI
J Med Chem 60: 5029-5044 (2017)
University Of Colorado Boulder
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures.EBI
J Med Chem 60: 4840-4860 (2017)
Eth Zurich
Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances.EBI
J Med Chem 60: 7941-7957 (2017)
University Of Porto
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11?-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.EBI
J Med Chem 60: 4932-4948 (2017)
Bristol-Myers Squibb
Novel propanamides as fatty acid amide hydrolase inhibitors.EBI
Eur J Med Chem 136: 523-542 (2017)
University Of Cagliari
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.EBI
J Med Chem 60: 4963-4982 (2017)
H�Pital Saint-Fran�Ois D'Assise
BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.EBI
J Med Chem 60: 4805-4817 (2017)
University Of Minnesota
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.EBI
Bioorg Med Chem 25: 3658-3670 (2017)
Takeda Pharmaceutical
Design, synthesis and biological evaluation of 4-piperazinyl-containing Chidamide derivatives as HDACs inhibitors.EBI
Bioorg Med Chem Lett 27: 3162-3166 (2017)
Shanghai Institute Of Pharmaceutical Industry
Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.EBI
J Med Chem 60: 5120-5145 (2017)
University Of Pennsylvania
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.EBI
J Med Chem 60: 5072-5085 (2017)
Vanderbilt University Institute Of Imaging Science
The impact of the halogen bonding on DEBI
Bioorg Med Chem 25: 3638-3648 (2017)
Jagiellonian University Medical College
Optimization and biological evaluation of 2-aminobenzothiazole derivatives as Aurora B kinase inhibitors.EBI
Bioorg Med Chem 25: 3614-3622 (2017)
Sookmyung Women'S University
Discovery of a potent dual ALK and EGFR T790M inhibitor.EBI
Eur J Med Chem 136: 497-510 (2017)
Harvard Medical School
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach.EBI
Eur J Med Chem 136: 487-496 (2017)
Universidade Estadual De Feira De Santana
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11? hydroxysteroid dehydrogenase type 1 inhibitor.EBI
Bioorg Med Chem 25: 3649-3657 (2017)
Vitae Pharmaceuticals
The relevance of KEBI
Eur J Med Chem 136: 480-486 (2017)
University Of Groningen
Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.EBI
Bioorg Med Chem 25: 3780-3791 (2017)
Fudan University
Recent updates on third generation EGFR inhibitors and emergence of fourth generation EGFR inhibitors to combat C797S resistance.EBI
Eur J Med Chem 142: 32-47 (2017)
R. C. Patel Institute Of Pharmaceutical Education And Research
Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells.EBI
Bioorg Med Chem Lett 27: 3026-3029 (2017)
Yeungnam University
Synthesis and molecular docking study of some 5,6-dichloro-2-cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease.EBI
Bioorg Med Chem Lett 27: 3014-3018 (2017)
Recep Tayyip Erdogan University
Discovery of a novel aminopyrazine series as selective PI3K? inhibitors.EBI
Bioorg Med Chem Lett 27: 3030-3035 (2017)
Astrazeneca
The discovery of novel, potent ERR-alpha inverse agonists for the treatment of triple negative breast cancer.EBI
Eur J Med Chem 136: 457-467 (2017)
Qilu University Of Technology
Structure-based rational design of self-inhibitory peptides to disrupt the intermolecular interaction between the troponin subunits C and I in neuropathic pain.BDB
Bioorg Chem 73: 10-15 (2017)
The Affiliated Hospital Of Qingdao University
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DPEBI
ACS Med Chem Lett 8: 582-586 (2017)
Novartis Institutes For Biomedical Research
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes.EBI
ACS Med Chem Lett 8: 560-565 (2017)
Janssen Research And Development
Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.EBI
ACS Med Chem Lett 8: 549-554 (2017)
Glaxosmithkline
2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors.EBI
ACS Med Chem Lett 8: 543-548 (2017)
Chinese Academy Of Sciences
Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis.EBI
ACS Med Chem Lett 8: 533-537 (2017)
Peking Union Medical College And Chinese Academy Of Medical Sciences
Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors.EBI
ACS Med Chem Lett 8: 510-515 (2017)
University Of Illinois At Chicago
Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.EBI
ACS Med Chem Lett 8: 504-509 (2017)
The University Of Tokyo
Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.EBI
ACS Med Chem Lett 8: 492-497 (2017)
Purdue University
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.EBI
ACS Med Chem Lett 8: 486-491 (2017)
Incyte
Similarity- and Substructure-Based Development of▀EBI
ACS Med Chem Lett 8: 481-485 (2017)
Philipps University Marburg
Modulation of the Inhibitors of Apoptosis Proteins (IAPs) Activities for Cancer Treatment.EBI
ACS Med Chem Lett 8: 471-473 (2017)
Therachem Research Medilab (India)
Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.EBI
Bioorg Med Chem 25: 3567-3573 (2017)
Universit£
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.EBI
Bioorg Med Chem 25: 3706-3713 (2017)
Peking University
Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.EBI
Bioorg Med Chem Lett 27: 2742-2745 (2017)
Kitasato University
Challenges in the development of an MEBI
Bioorg Med Chem Lett 27: 2990-2995 (2017)
Vanderbilt University School Of Medicine
Hetarylcoumarins: Synthesis and biological evaluation as potent a-glucosidase inhibitors.BDB
Bioorg Chem 73: 1-9 (2017)
Kinnaird College For Women
2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.EBI
Eur J Med Chem 135: 531-543 (2017)
Guangzhou Institutes Of Biomedicine And Health
Design and Synthesis of Soluble and Cell-Permeable PI3K? Inhibitors for Long-Acting Inhaled Administration.EBI
J Med Chem 60: 5057-5071 (2017)
Astrazeneca
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.EBI
J Med Chem 60: 4904-4922 (2017)
Clemson University
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.EBI
Bioorg Med Chem Lett 27: 2974-2981 (2017)
Genentech
Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.EBI
Bioorg Med Chem Lett 27: 2678-2682 (2017)
Takeda California
Evaluation of synthesized coumarin derivatives on aromatase inhibitory activity.EBI
Bioorg Med Chem Lett 27: 2645-2649 (2017)
Health Sciences University Of Hokkaido
Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-?-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease.EBI
Bioorg Med Chem Lett 27: 2962-2966 (2017)
University Of Utah
Sulfonamide inhibition profiles of the?-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia.EBI
Bioorg Med Chem 25: 3555-3561 (2017)
Universit£
Potential anti-gout constituents as xanthine oxidase inhibitor from the fruits of Stauntonia brachyanthera.EBI
Bioorg Med Chem 25: 3562-3566 (2017)
Shenyang Pharmaceutical University
Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives.EBI
Bioorg Med Chem 25: 3547-3554 (2017)
Anadolu University
Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups.EBI
Bioorg Med Chem 25: 2981-2994 (2017)
Shandong University
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.EBI
Eur J Med Chem 136: 348-359 (2017)
Chinese Academy Of Sciences
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.EBI
J Med Chem 60: 4279-4292 (2017)
Karolinska Institutet
Phenylbenzenesulfonates and -sulfonamides as 17?-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis.EBI
Bioorg Med Chem Lett 27: 2982-2985 (2017)
University Of Innsbruck
Recent progress towards clinically relevant ATP-competitive Akt inhibitors.EBI
Bioorg Med Chem Lett 27: 2838-2848 (2017)
Merck
CEBI
Bioorg Med Chem 25: 3512-3524 (2017)
Guizhou University
Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold.EBI
Bioorg Med Chem 25: 3461-3470 (2017)
The University Of Tokyo
Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy.EBI
Bioorg Med Chem 25: 3531-3539 (2017)
Wuhan University School Of Pharmaceutical Sciences
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.EBI
Eur J Med Chem 136: 334-347 (2017)
University Of Illinois At Chicago
Investigation of pyrazolo-sulfonamides as putative small molecule oxytocin receptor agonists.EBI
Eur J Med Chem 136: 330-333 (2017)
The University Of Sydney
Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors.EBI
Eur J Med Chem 136: 315-329 (2017)
National Research Centre
Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.EBI
Eur J Med Chem 136: 294-304 (2017)
University Of Maribor
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.EBI
Eur J Med Chem 136: 283-293 (2017)
Takeda Pharmaceutical
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.EBI
J Med Chem 61: 3239-3252 (2018)
Temple University
Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.EBI
Bioorg Med Chem 25: 3500-3511 (2017)
Shenyang Pharmaceutical University
Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment.BDB
Bioorg Chem 72: 315-322 (2017)
Medical University Of Lodz
Stabilizing HDAC11 with SAHA to assay slow-binding benzamide inhibitors.EBI
Bioorg Med Chem Lett 27: 2943-2945 (2017)
Nankai University
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.EBI
Bioorg Med Chem Lett 27: 2721-2726 (2017)
Astrazeneca
Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure? ligands with 2-benzopyran structure.EBI
Bioorg Med Chem 25: 3384-3395 (2017)
Universit£T M£Nster
Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.BDB
Bioorg Chem 72: 308-314 (2017)
Cairo University
Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of?-opioid receptor antagonists.EBI
Bioorg Med Chem Lett 27: 2926-2930 (2017)
Theravance Biopharma Us
Quinazoline based ?EBI
Eur J Med Chem 136: 259-269 (2017)
Alma Mater Studiorum-University Of Bologna
Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties.EBI
Eur J Med Chem 136: 223-234 (2017)
Instituto De Qu£Mica M£Dica
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.EBI
J Med Chem 60: 5521-5542 (2017)
Pfizer
Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans.EBI
J Med Chem 60: 4657-4664 (2017)
Novartis Institutes For Biomedical Research
Development of molecular tools based on the dopamine DEBI
Bioorg Med Chem 25: 3491-3499 (2017)
Friedrich-Alexander University
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.EBI
Bioorg Med Chem 25: 3471-3482 (2017)
University Of Cambridge
Reevaluation of fenpropimorph as a? receptor ligand: Structure-affinity relationship studies at human?EBI
Bioorg Med Chem Lett 27: 2912-2919 (2017)
Virginia Commonwealth University
Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.EBI
Bioorg Med Chem Lett 27: 2907-2911 (2017)
Mcdaniel College
Designing multi-targeted agents: An emerging anticancer drug discovery paradigm.EBI
Eur J Med Chem 136: 195-211 (2017)
Hunan University Of Chinese Medicine
Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors.EBI
Eur J Med Chem 136: 184-194 (2017)
Birla Institute Of Technology
Tamarixetin 3-O-?-d-Glucopyranoside from Azadirachta indica Leaves: Gastroprotective Role through Inhibition of Matrix Metalloproteinase-9 Activity in Mice.EBI
J Nat Prod 80: 1347-1353 (2017)
National Institute Of Pharmaceutical Education And Research
Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A).EBI
J Med Chem 60: 4626-4635 (2017)
San Francisco State University
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.EBI
J Med Chem 60: 4559-4572 (2017)
Janssen Research And Development
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).EBI
J Med Chem 60: 4611-4625 (2017)
Astex Pharmaceuticals
Return of DEBI
J Med Chem 60: 7233-7243 (2017)
University Of Nebraska Medical Center
Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for?-Arrestin-Biased DEBI
J Med Chem 60: 4693-4713 (2017)
Friedrich-Alexander University Erlangen-Nuernberg
Atropisomerism and Conformational Equilibria: Impact on PI3K? Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.EBI
J Med Chem 60: 4304-4315 (2017)
Universit£
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI
Bioorg Med Chem 25: 3006-3017 (2017)
Nanyang Normal University
N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1?/? inhibitors: Synthesis, biological evaluation and molecular modeling studies.EBI
Bioorg Med Chem Lett 27: 2663-2667 (2017)
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.EBI
J Med Chem 60: 4386-4402 (2017)
Astrazeneca
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR?-Targeted Antidiabetics.EBI
J Med Chem 60: 4584-4593 (2017)
The Scripps Research Institute
Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EPEBI
Bioorg Med Chem 25: 3406-3430 (2017)
Kyorin Pharmaceutical
Bivalent O-glycoside mimetics with S/disulfide/Se substitutions and aromatic core: Synthesis, molecular modeling and inhibitory activity on biomedically relevant lectins in assays of increasing physiological relevance.EBI
Bioorg Med Chem 25: 3158-3170 (2017)
Ludwig-Maximilians-University Munich
Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.EBI
Eur J Med Chem 136: 63-73 (2017)
China Pharmaceutical University
Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.EBI
J Med Chem 60: 7213-7232 (2017)
King'S College London
Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.EBI
J Med Chem 60: 4636-4656 (2017)
Eberhard Karls Universit£T T£Bingen
1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.EBI
J Med Chem 60: 4234-4244 (2017)
Jagiellonian University
Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.EBI
J Med Chem 60: 4594-4610 (2017)
Indiana University School Of Medicine
Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.BDB
ACS Chem Biol 12: 1787-1795 (2017)
University Of Strasburg
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.EBI
J Med Chem 60: 4424-4443 (2017)
Shandong University
Heme Proximal Hydrogen Bonding between His170 and Asp132 Plays an Essential Role in the Heme Degradation Reaction of HutZ from Vibrio cholerae.BDB
Biochemistry 56: 2723-2734 (2017)
Hokkaido University
Conformational control in structure-based drug design.EBI
Bioorg Med Chem Lett 27: 2825-2837 (2017)
Allergan
Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors.EBI
Bioorg Med Chem Lett 27: 2708-2712 (2017)
Martin-Luther-University Halle-Wittenberg
Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles.EBI
Bioorg Med Chem Lett 27: 2803-2806 (2017)
Chinese Academy Of Sciences
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.EBI
Eur J Med Chem 136: 36-51 (2017)
Jamia Millia Islamia (Central University)
Methyllysine binding domains: Structural insight and small molecule probe development.EBI
Eur J Med Chem 136: 14-35 (2017)
University Of Connecticut
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity.EBI
Eur J Med Chem 135: 491-516 (2017)
University Of Nis
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.EBI
Eur J Med Chem 135: 467-478 (2017)
Universit£
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.EBI
J Med Chem 60: 4714-4733 (2017)
H�Pital Kirchberg
Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form.EBI
J Med Chem 60: 4503-4509 (2017)
Teikyo University
Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation.EBI
J Med Chem 60: 4135-4146 (2017)
Guangzhou Institutes Of Biomedicine And Health
Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).EBI
J Med Chem 60: 4403-4423 (2017)
Pharmakea Therapeutics
Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling.EBI
J Med Chem 60: 4882-4892 (2017)
University Of Milano-Bicocca
Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach.EBI
J Med Chem 60: 4358-4368 (2017)
Takeda Pharmaceutical
4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).EBI
J Med Chem 60: 4474-4495 (2017)
University Of Bonn
Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein.EBI
Bioorg Med Chem Lett 27: 2781-2787 (2017)
The University Of Tokyo
Benzoxazolinone aryl sulfonamides as potent, selective NaEBI
Bioorg Med Chem Lett 27: 2683-2688 (2017)
Merck
Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus.EBI
Bioorg Med Chem Lett 27: 2788-2792 (2017)
Beijing Institute Of Pharmacology & Toxicology
Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors.EBI
Bioorg Med Chem Lett 27: 2695-2701 (2017)
Merck
Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression.EBI
Bioorg Med Chem Lett 27: 2776-2780 (2017)
The University Of Tokyo
Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.EBI
Eur J Med Chem 135: 401-413 (2017)
Universit£T M£Nster
Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells.EBI
J Med Chem 60: 4665-4679 (2017)
Cnrs-Pierre Fabre Usr3388
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.EBI
J Med Chem 60: 3887-3901 (2017)
University Of Michigan
Design and optimization of purine derivatives as in vivo active PDE10A inhibitors.EBI
Bioorg Med Chem 25: 3315-3329 (2017)
Nanchang University
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-?-benzyl ester derivatives as potent topoisomerase II? inhibitors.EBI
Bioorg Med Chem 25: 3116-3126 (2017)
Hebei University
Design, synthesis and evaluation of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acid derivatives as ETEBI
Bioorg Med Chem Lett 27: 2281-2285 (2017)
St. John'S University
Iodine catalyzed three component synthesis of 1-((2-hydroxy naphthalen-1-yl)(phenyl)(methyl))pyrrolidin-2-one derivatives: Rationale as potent PI3K inhibitors and anticancer agents.EBI
Bioorg Med Chem Lett 27: 2510-2514 (2017)
Vit University
The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.EBI
Bioorg Med Chem Lett 27: 2629-2633 (2017)
Aarhus University
Neutral macrocyclic factor VIIa inhibitors.EBI
Bioorg Med Chem Lett 27: 2650-2654 (2017)
Bristol-Myers Squibb Research And Development
Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors.BDB
Bioorg Chem 72: 182-189 (2017)
China Pharmaceutical University
Synthesis and biological evaluation of benzimidazole derivatives as the G9a Histone Methyltransferase inhibitors that induce autophagy and apoptosis of breast cancer cells.BDB
Bioorg Chem 72: 168-181 (2017)
Shenyang Pharmaceutical University
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3? inhibitors for the treatment of ovarian cancer.EBI
Eur J Med Chem 135: 370-381 (2017)
Fudan University
7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.EBI
J Med Chem 60: 4212-4233 (2017)
University Of Auckland
Neuroprotective and Antineuroinflammatory Effects of Hydroxyl-Functionalized Stilbenes and 2-Arylbenzo[b]furans.EBI
J Med Chem 60: 4062-4073 (2017)
National Yang-Ming University
Synthesis of selective 11?-HSD1 inhibitors based on dammarane scaffold.EBI
Eur J Med Chem 135: 324-338 (2017)
Chinese Academy Of Sciences
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 135: 307-323 (2017)
Sichuan University
Inhibitors of cytochrome P450 (CYP) 1B1.EBI
Eur J Med Chem 135: 296-306 (2017)
Universit£
Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging.EBI
Bioorg Med Chem Lett 27: 2757-2761 (2017)
Takeda Pharmaceutical
Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.EBI
Bioorg Med Chem 25: 3368-3376 (2017)
University Of Malakand
The evaluation of 1,4-benzoquinones as inhibitors of human monoamine oxidase.EBI
Eur J Med Chem 135: 196-203 (2017)
North-West University
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.EBI
Bioorg Med Chem 25: 3330-3349 (2017)
Takeda Pharmaceutical
Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.EBI
Bioorg Med Chem 25: 2946-2955 (2017)
Sun Yat-Sen University
Structure-related protein tyrosine phosphatase 1B inhibition by naringenin derivatives.EBI
Bioorg Med Chem Lett 27: 2274-2280 (2017)
Chonbuk National University
Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents.EBI
Eur J Med Chem 135: 213-229 (2017)
Universidade Federal Fluminense
Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors.EBI
Eur J Med Chem 135: 174-195 (2017)
Ghent University
Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.EBI
J Med Chem 60: 4316-4326 (2017)
Universit£
Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-XaaEBI
J Med Chem 60: 4342-4357 (2017)
University Of Minnesota
Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge.EBI
J Nat Prod 80: 1575-1583 (2017)
Seoul National University
Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.EBI
J Med Chem 60: 4293-4303 (2017)
Sanofi-Aventis Deutschland
Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes.EBI
J Med Chem 60: 4173-4184 (2017)
Haisco Pharmaceuticals Group
Exploring the Role of NEBI
J Med Chem 60: 4327-4341 (2017)
University Of Camerino
Metallo-?-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.EBI
Eur J Med Chem 135: 159-173 (2017)
Uit The Arctic University Of Norway
Neomacrophorin X, a [4.4.3]Propellane-Type Meroterpenoid from Trichoderma sp. 1212-03.EBI
J Nat Prod 80: 1484-1492 (2017)
Hirosaki University
Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.EBI
J Med Chem 60: 3672-3683 (2017)
Novartis Institutes For Biomedical Research
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.EBI
J Med Chem 60: 3626-3635 (2017)
Regina Elena National Cancer Institute
Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum.EBI
J Nat Prod 80: 1493-1504 (2017)
Chinese Academy Of Sciences
Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.EBI
J Med Chem 60: 4458-4473 (2017)
Genentech
Synthesis of benzoxazole derivatives as interleukin-6 antagonists.EBI
Bioorg Med Chem 25: 3127-3134 (2017)
Ewha Womans University
Optimization of MEBI
Bioorg Med Chem Lett 27: 2296-2301 (2017)
Vanderbilt University Medical Center
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.EBI
Bioorg Med Chem Lett 27: 2313-2318 (2017)
Ranbaxy Laboratories
Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine.EBI
Eur J Med Chem 135: 142-158 (2017)
Palack£
The computer-aided discovery of novel family of the 5-HTEBI
Eur J Med Chem 135: 117-124 (2017)
Jagiellonian University
Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.BDB
Biochemistry 56: 2506-2517 (2017)
University Of Washington
Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy.EBI
J Med Chem 60: 4444-4457 (2017)
F. Hoffmann-La Roche
Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay.BDB
ACS Chem Biol 12: 1760-1768 (2017)
Bc Cancer Agency
Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach.EBI
Bioorg Med Chem Lett 27: 2324-2330 (2017)
Punjabi University
Potent and selective oxytocin receptor agonists without disulfide bridges.EBI
Bioorg Med Chem Lett 27: 2331-2335 (2017)
Takeda Pharmaceutical
Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth.EBI
Bioorg Med Chem 25: 2995-3005 (2017)
Indiana University School Of Medicine
Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism.EBI
Eur J Med Chem 134: 334-347 (2017)
Csir-Indian Institute Of Chemical Biology
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.EBI
J Med Chem 60: 4093-4098 (2017)
University Of Dundee
Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries.EBI
ACS Med Chem Lett 8: 461-465 (2017)
Abbvie
Norbenzomorphan Scaffold: Chemical Tool for Modulating Sigma Receptor-Subtype Selectivity.EBI
ACS Med Chem Lett 8: 455-460 (2017)
The University Of Texas At Austin
Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge.EBI
ACS Med Chem Lett 8: 449-454 (2017)
Universit£
Discovery of Antimalarial Azetidine-2-carbonitriles That InhibitEBI
ACS Med Chem Lett 8: 438-442 (2017)
Harvard University
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.EBI
ACS Med Chem Lett 8: 423-427 (2017)
Pharmakea
Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.EBI
ACS Med Chem Lett 8: 413-417 (2017)
Kezar Life Sciences
Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment.EBI
ACS Med Chem Lett 8: 407-412 (2017)
Peking University
Pyrano[2,3,4-EBI
ACS Med Chem Lett 8: 390-394 (2017)
Polish Academy Of Sciences
Discovery of [1,2,3]Triazolo[4,5-EBI
ACS Med Chem Lett 8: 384-389 (2017)
Key Laboratory Of Technology Of Drug Preparation (Zhengzhou University)
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.EBI
Bioorg Med Chem 25: 3223-3234 (2017)
University Of Montana
4-Connected azabicyclo[5.3.0]decane Smac mimetics-ZnEBI
Bioorg Med Chem Lett 27: 2336-2344 (2017)
Istituto Di Scienze E Tecnologie Molecolari (Istm)
N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.EBI
Eur J Med Chem 134: 415-427 (2017)
Ume£
Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs.EBI
Eur J Med Chem 134: 392-405 (2017)
National Research Centre
Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping.EBI
Bioorg Med Chem Lett 27: 2420-2423 (2017)
Wuxi Apptec (Shanghai)
Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists.EBI
Bioorg Med Chem 25: 3098-3115 (2017)
Takeda Pharmaceutical
Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia.EBI
Eur J Med Chem 135: 60-69 (2017)
Dalian Medical University
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.EBI
Bioorg Med Chem Lett 27: 2559-2566 (2017)
Merck
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent inávitro antileishmanial activityEBI
Eur J Med Chem 135: 49-59 (2017)
Instituto De Qu£Mica M£Dica (Iqm-Csic)
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.EBI
Eur J Med Chem 135: 34-48 (2017)
Wuhan University Of Technology
Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.EBI
Eur J Med Chem 134: 366-378 (2017)
Padmashri Vikhe Patil College Of Arts
Eco-friendly synthesis of novel cyanopyridine derivatives and their anticancer and PIM-1 kinase inhibitory activities.EBI
Eur J Med Chem 134: 357-365 (2017)
Ain Shams University
First macrocyclic 3EBI
Eur J Med Chem 134: 348-356 (2017)
Taibah University
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.EBI
Eur J Med Chem 134: 316-333 (2017)
Sapienza University Of Rome
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.EBI
J Med Chem 60: 4369-4385 (2017)
Bristol-Myers Squibb Research And Development
Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin.EBI
Bioorg Med Chem 25: 3087-3092 (2017)
Vanderbilt University
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors.EBI
Bioorg Med Chem 25: 3148-3157 (2017)
Jiangxi Science & Technology Normal University
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.EBI
Bioorg Med Chem Lett 27: 2432-2438 (2017)
Purdue University
Novel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations.EBI
Bioorg Med Chem Lett 27: 2377-2383 (2017)
Suez Canal University
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.EBI
Bioorg Med Chem Lett 27: 2479-2483 (2017)
Vanderbilt University School Of Medicine
Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules.EBI
Eur J Med Chem 134: 304-315 (2017)
King Saud University
Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90.EBI
Eur J Med Chem 135: 24-33 (2017)
Ocean University Of China
Design, synthesis, SAR discussion, inávitro and inávivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.EBI
Eur J Med Chem 135: 12-23 (2017)
Nanjing Normal University
Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ER? and ER? Activity.EBI
J Med Chem 61: 514-534 (2018)
Trinity College
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.BDB
J Med Chem 61: 535-542 (2017)
Celgene
?-Glucosidase Inhibitors from Salvia circinata.EBI
J Nat Prod 80: 1584-1593 (2017)
Universidad Nacional Aut£Noma De M£Xico
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.EBI
J Med Chem 60: 3958-3978 (2017)
Northwestern University
Synthetic Approaches to the New Drugs Approved During 2015.EBI
J Med Chem 60: 6480-6515 (2017)
Pfizer
Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors.EBI
Eur J Med Chem 134: 281-292 (2017)
Tsinghua University
Selective IEBI
J Med Chem 60: 3795-3803 (2017)
Bristol-Myers Squibb
Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl-DNA Phosphodiesterase 2 (Tdp2).EBI
J Med Chem 60: 3275-3288 (2017)
Purdue University
Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus.EBI
J Med Chem 60: 3727-3738 (2017)
Universitat De Barcelona
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.EBI
Bioorg Med Chem Lett 27: 2384-2388 (2017)
Merck Research Laboratories
Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors.EBI
Bioorg Med Chem 25: 3171-3181 (2017)
California State University
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.EBI
Bioorg Med Chem 25: 3583-3589 (2017)
Latvian Institute Of Organic Synthesis
Synthesis and biological evaluation of largazole zinc-binding group analogs.EBI
Bioorg Med Chem 25: 3077-3086 (2017)
Duke University
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.EBI
Eur J Med Chem 134: 230-241 (2017)
Xihua University
Design and synthesis of novel xanthine derivatives as potent and selective AEBI
Eur J Med Chem 134: 218-229 (2017)
Advinus Therapeutics
Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.EBI
Eur J Med Chem 134: 185-206 (2017)
Shandong University
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.EBI
J Med Chem 60: 4185-4211 (2017)
Universities Of Lille
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary FibEBI
J Med Chem 60: 3580-3590 (2017)
Galapagos
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.EBI
Eur J Med Chem 134: 159-184 (2017)
Punjabi University
A calcineurin antifungal strategy with analogs of FK506.EBI
Bioorg Med Chem Lett 27: 2465-2471 (2017)
Amplyx Pharmaceuticals
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.EBI
Bioorg Med Chem 25: 3195-3205 (2017)
Hangzhou Xixi Hospital
Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization.EBI
Eur J Med Chem 134: 147-158 (2017)
Shanghai Pharmaceuticals Holding
New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.BDB
Bioorg Chem 72: 123-129 (2017)
Beni-Suef University
Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitorsBDB
Bioorg Chem 72: 116-122 (2017)
China Pharmaceutical University
Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.EBI
Bioorg Med Chem Lett 27: 2472-2478 (2017)
University Of Z£Rich
Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors.EBI
J Med Chem 60: 4023-4035 (2017)
West China Hospital Of Sichuan University
Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods.EBI
Bioorg Med Chem Lett 27: 2520-2527 (2017)
Charles River Discovery Research Services
Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2XEBI
Bioorg Med Chem Lett 27: 2439-2442 (2017)
The University Of Sydney
Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.EBI
Bioorg Med Chem Lett 27: 2622-2628 (2017)
Mochida Pharmaceutical
Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective.EBI
Bioorg Med Chem Lett 27: 2239-2258 (2017)
Intellisyn Pharma
First insight into structure-activity relationships of selective meprin? inhibitors.EBI
Bioorg Med Chem Lett 27: 2428-2431 (2017)
Fraunhofer Institute For Cell Therapy And Immunology Izi
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.EBI
Bioorg Med Chem Lett 27: 2617-2621 (2017)
Rigel Pharmaceuticals
Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist.EBI
Bioorg Med Chem Lett 27: 2515-2519 (2017)
Jiangxi University Of Traditional Chinese Medicine
Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B.EBI
Bioorg Med Chem 25: 3046-3052 (2017)
Kyoto University
An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors.EBI
Eur J Med Chem 132: 322-332 (2017)
Universidade Estadual De Feira De Santana
Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.EBI
J Med Chem 60: 3933-3957 (2017)
University Of Virginia
Polyketides and Anthranilic Acid Possessing 6-Deoxy-?-l-talopyranose from a Streptomyces Species.EBI
J Nat Prod 80: 1378-1386 (2017)
Korea Research Institute Of Bioscience And Biotechnology
First Dual Inhibitors of Steroid Sulfatase (STS) and 17?-Hydroxysteroid Dehydrogenase Type 1 (17?-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.EBI
J Med Chem 60: 4086-4092 (2017)
Saarland University
Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.EBI
J Med Chem 60: 3636-3655 (2017)
University Of Bonn
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.EBI
J Med Chem 60: 3472-3483 (2017)
Dart Neuroscience
Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.EBI
J Med Chem 60: 3776-3794 (2017)
Actelion Pharmaceuticals
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.EBI
J Med Chem 60: 3755-3775 (2017)
Actelion Pharmaceuticals
Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors.BDB
ACS Chem Biol 12: 1538-1546 (2017)
University Of Helsinki
Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.EBI
Bioorg Med Chem 25: 3053-3058 (2017)
University Of Missouri St. Louis
Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids.EBI
Bioorg Med Chem 25: 2817-2824 (2017)
Nc State University
Synthesis and structure-activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors.EBI
Bioorg Med Chem Lett 27: 2544-2548 (2017)
University Of Science And Technology Of China
Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.EBI
Bioorg Med Chem Lett 27: 2536-2543 (2017)
Spanish National Cancer Research Centre (Cnio)
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.EBI
J Med Chem 60: 4002-4022 (2017)
Bayer
Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic.EBI
Bioorg Med Chem Lett 27: 2590-2593 (2017)
National Institute Of Health Sciences
Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.EBI
Bioorg Med Chem Lett 27: 2443-2449 (2017)
University Of Waterloo
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin EEBI
Bioorg Med Chem Lett 27: 2594-2601 (2017)
Glenmark Pharmaceuticals
Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors.EBI
Bioorg Med Chem Lett 27: 2497-2501 (2017)
Takeda Pharmaceutical
Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction.EBI
Bioorg Med Chem Lett 27: 2571-2574 (2017)
Kyoto University
Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors.EBI
Bioorg Med Chem 25: 3093-3097 (2017)
Adiyaman University
Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain.EBI
Eur J Med Chem 134: 86-96 (2017)
Institute Of Genetics And Molecular And Cellular Biology (Igbmc)
Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.EBI
Eur J Med Chem 134: 62-71 (2017)
University Of Texas Medical Branch
Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.EBI
J Med Chem 60: 3979-4001 (2017)
Ut Southwestern Medical Center
Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper.EBI
J Nat Prod 80: 1436-1445 (2017)
Shanghai Jiao Tong University
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.EBI
J Med Chem 60: 3383-3404 (2017)
Glaxosmithkline
Synthesis and biological evaluation of morpholine-substituted diphenylpyrimidine derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors with improved activity toward the gefitinib-resistant non-small cell lung cancers (NSCLC).EBI
Eur J Med Chem 133: 329-339 (2017)
Dalian Medical University
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.EBI
Eur J Med Chem 134: 24-33 (2017)
Chinese Academy Of Sciences
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors inávitro and inávivo.EBI
Eur J Med Chem 134: 13-23 (2017)
Taipei Medical University (Tmu)
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.EBI
J Med Chem 60: 4680-4692 (2017)
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Moe) And Hubei Provinc
N-(Aroyl)-N-(arylmethyloxy)-?-alanines: Selective inhibitors of aldose reductase.EBI
Bioorg Med Chem 25: 3068-3076 (2017)
Universit£
Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential.EBI
Bioorg Med Chem 25: 3018-3033 (2017)
Takeda Pharmaceutical
Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKC?, PKC?, and RasGRP.EBI
Bioorg Med Chem 25: 2971-2980 (2017)
National Institute Of Industrial Technology
Novel 5-HTEBI
Bioorg Med Chem 25: 2789-2799 (2017)
Jagiellonian University Medical College
Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents.EBI
Eur J Med Chem 134: 1-12 (2017)
Beijing University Of Chemical Technology
Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies.BDB
Bioorg Chem 72: 89-101 (2017)
University Of Karachi
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.BDB
Bioorg Chem 72: 102-115 (2017)
Alexandria University
Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).EBI
Bioorg Med Chem Lett 27: 2099-2101 (2017)
University Of East Anglia
Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGluEBI
Eur J Med Chem 133: 240-254 (2017)
Gedeon Richter
A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B.EBI
Bioorg Med Chem Lett 27: 2207-2209 (2017)
Tohoku Medical And Pharmaceutical University
Discovery of selective, orally bioavailable, N-linked arylsulfonamide NaEBI
Bioorg Med Chem Lett 27: 2087-2093 (2017)
Department Of Discovery Chemistry Merck
Facile access to pseudo-thio-1,2-dimannoside, a new glycomimetic DC-SIGN antagonist.EBI
Bioorg Med Chem 25: 5142-5147 (2017)
Universita' Degli Studi Di Milano
Mycobacterium tuberculosis lysine-?-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors.EBI
Bioorg Med Chem 25: 2761-2771 (2017)
Birla Institute Of Technology & Science-Pilani
Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII.EBI
Bioorg Med Chem 25: 2782-2788 (2017)
Universit£
Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity.EBI
Bioorg Med Chem 25: 2800-2810 (2017)
Shenyang Pharmaceutical University
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.EBI
Eur J Med Chem 133: 184-196 (2017)
Shanghai University Of Traditional Chinese Medicine
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the MEBI
J Med Chem 60: 3314-3334 (2017)
University Of Regensburg
Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity.BDB
Biochemistry 56: 2294-2303 (2017)
North Carolina State University
C-2 (E)-4-(Styryl)aniline substituted diphenylpyrimidine derivatives (Sty-DPPYs) as specific kinase inhibitors targeting clinical resistance related EGFREBI
Bioorg Med Chem 25: 2724-2729 (2017)
Dalian Medical University
Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors.EBI
Bioorg Med Chem Lett 27: 2144-2147 (2017)
Hokkaido University
Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor.EBI
Bioorg Med Chem Lett 27: 2185-2191 (2017)
University Of Science & Technology
The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia.EBI
Bioorg Med Chem Lett 27: 2210-2215 (2017)
Wuxi Apptec (Shanghai)
Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer.EBI
Bioorg Med Chem Lett 27: 2216-2220 (2017)
Drexel University College Of Medicine
Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors.EBI
Eur J Med Chem 133: 97-106 (2017)
Jiangxi Science And Technology Normal University
Synthesis and preliminary biological assay of uridine glycoconjugate derivatives containing amide and/or 1,2,3-triazole linkers.BDB
Bioorg Chem 72: 80-88 (2017)
Silesian University Of Technology
Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.EBI
J Med Chem 60: 6461-6479 (2017)
Tsinghua University
NEBI
J Med Chem 60: 3422-3437 (2017)
Seoul National University
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).EBI
J Med Chem 61: 482-491 (2018)
University Of Freiburg
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.EBI
Bioorg Med Chem Lett 27: 2153-2160 (2017)
Integral Biosciences
Original endomorphin-1 analogues exhibit good analgesic effects with minimal implications for human sperm motility.EBI
Bioorg Med Chem Lett 27: 2119-2123 (2017)
The Reproductive Medicine Special Hospital Of The First Hospital Of Lanzhou University
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.EBI
J Med Chem 60: 3438-3450 (2017)
Astrazeneca
Origins of PDZ Binding Specificity. A Computational and Experimental Study Using NHERF1 and the Parathyroid Hormone Receptor.BDB
Biochemistry 56: 2584-2593 (2017)
The University Of Queensland
Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-┐1 Protein.BDB
Biochemistry 56: 2225-2237 (2017)
University Of Colorado Boulder
Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.EBI
J Med Chem 60: 3866-3878 (2017)
The University Of Kansas
Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.EBI
J Med Chem 60: 5349-5363 (2017)
Pfizer
Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.EBI
J Med Chem 60: 3187-3197 (2017)
Astrazeneca
Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine HEBI
Bioorg Med Chem 25: 2701-2712 (2017)
Jagiellonian University Medical College
Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.EBI
Bioorg Med Chem Lett 27: 2201-2206 (2017)
Sygnature Discovery
Y-shaped bis-arylethenesulfonic acid esters: Potential potent and membrane permeable protein tyrosine phosphatase 1B inhibitors.EBI
Bioorg Med Chem Lett 27: 2166-2170 (2017)
Shanghai Jiao Tong University
Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors.EBI
Eur J Med Chem 133: 11-23 (2017)
Shandong University
Synthesis and study of anti-HIV-1 RT activity of 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives.BDB
Bioorg Chem 72: 74-79 (2017)
Birla Institute Of Technology
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.EBI
Eur J Med Chem 132: 294-309 (2017)
China Pharmaceutical University
Enantiospecific Recognition at the AEBI
J Med Chem 60: 3372-3382 (2017)
Uppsala University
Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens.EBI
J Nat Prod 80: 798-804 (2017)
Yunnan University
Exploring Derivatives of Quinazoline Alkaloid l-Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluation of Novel Antitumor Histone Deacetylase Inhibitors.EBI
J Med Chem 60: 3484-3497 (2017)
Csir-Indian Institute Of Integrative Medicine
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.EBI
J Med Chem 60: 3303-3313 (2017)
University Of Montpellier
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.EBI
J Med Chem 60: 3405-3421 (2017)
Corcept Therapeutics
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.EBI
J Med Chem 60: 3828-3850 (2017)
Abbvie
Design and synthesis of quinazolinones as EGFR inhibitors to overcome EGFR resistance obstacle.EBI
Bioorg Med Chem 25: 2713-2723 (2017)
R. C. Patel Institute Of Pharmaceutical Education And Research
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.EBI
Bioorg Med Chem Lett 27: 1897-1901 (2017)
Takeda Pharmaceutical
Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors.EBI
Bioorg Med Chem 25: 2593-2600 (2017)
Nanjing University
4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures.EBI
Bioorg Med Chem Lett 27: 1902-1906 (2017)
Daiichi Sankyo
Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors.EBI
Bioorg Med Chem Lett 27: 1955-1961 (2017)
Takeda California
Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors.EBI
Bioorg Med Chem 25: 5077-5083 (2017)
University Of Florence
Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors.EBI
J Med Chem 60: 3335-3351 (2017)
Takeda Pharmaceutical
Discovery of Novel Indazole Derivatives as Orally Available?EBI
J Med Chem 60: 3252-3265 (2017)
Asahi Kasei Pharma
Design, Synthesis, and Experimental Validation of Peptide Ligands Targeting Mycobacterium tuberculosis s Factors.BDB
Biochemistry 56: 2209-2218 (2017)
Indian Institute Of Science
Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth.EBI
Bioorg Med Chem 25: 2609-2616 (2017)
The University Of Texas At Austin
New potent and selective?v?EBI
Bioorg Med Chem Lett 27: 1911-1913 (2017)
Jiangnan University
Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors.EBI
Bioorg Med Chem Lett 27: 1919-1922 (2017)
Chinese Academy Of Sciences
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors.EBI
Eur J Med Chem 132: 157-172 (2017)
Fudan University
Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.EBI
Bioorg Med Chem Lett 27: 2003-2009 (2017)
Nanchang University
Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3K?/? inhibitors for the treatment of PTEN-deficient tumours.EBI
Bioorg Med Chem Lett 27: 1949-1954 (2017)
Astrazeneca
Discovery of small molecule inhibitors for the snake venom metalloprotease BaP1 using in silico and in vitro tests.EBI
Bioorg Med Chem Lett 27: 2018-2022 (2017)
Unicamp
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.EBI
Bioorg Med Chem 25: 2569-2576 (2017)
Universit£
Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?EBI
Bioorg Med Chem 25: 5107-5113 (2017)
Helmholtz-Zentrum Dresden-Rossendorf
Synthesis, in vitro evaluation and molecular docking studies of novel amide linked triazolyl glycoconjugates as new inhibitors of a-glucosidase.BDB
Bioorg Chem 72: 11-20 (2017)
Csir-Indian Institute Of Chemical Biology
Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng.EBI
J Nat Prod 80: 899-908 (2017)
Chinese Academy Of Sciences
Asymmetric Anchoring Is Required for Efficient O-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase.BDB
Biochemistry 56: 2106-2115 (2017)
University Of Waterloo
Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate.BDB
Biochemistry 56: 2051-2060 (2017)
University Of Missouri
Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a.BDB
Cell Chem Biol 24: 458-470 (2017)
Jagiellonian University
Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.EBI
Bioorg Med Chem Lett 27: 1943-1948 (2017)
Shenyang Pharmaceutical University
Inhibition of Malassezia globosa carbonic anhydrase with phenols.EBI
Bioorg Med Chem 25: 2577-2582 (2017)
University Of Tehran
Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review.EBI
Eur J Med Chem 132: 108-134 (2017)
Indo-Soviet Friendship College Of Pharmacy (Isfcp)
Novel pyrazolo[1,5-a]pyridines as orally active EPEBI
Bioorg Med Chem 25: 2635-2642 (2017)
Kyorin Pharmaceutical
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase II? inhibitors and antiproliferative agents.EBI
Bioorg Med Chem 25: 2625-2634 (2017)
National And Kapodistrian University Of Athens
Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.EBI
Bioorg Med Chem 25: 2657-2665 (2017)
University Of Oxford
Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis.EBI
Bioorg Med Chem 25: 2643-2656 (2017)
University Health Network
Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.EBI
Bioorg Med Chem 25: 67-74 (2017)
Advinus Therapeutics
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.EBI
Bioorg Med Chem 25: 166-174 (2017)
Soochow University
Synthesis, activity and docking studies of phenylpyrimidine-carboxamide Sorafenib derivatives.EBI
Bioorg Med Chem 24: 6166-6173 (2016)
Jiangxi Science & Technology Normal University
Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents.EBI
Eur J Med Chem 132: 42-62 (2017)
Mashhad University Of Medical Sciences
Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with inávivo anti-tumor activity.EBI
Eur J Med Chem 132: 26-41 (2017)
Chinese Academy Of Medical Sciences & Peking Union Medical College
Synthesis, in vitro antiproliferative activity and kinase profile of new benzimidazole and benzotriazole derivatives.BDB
Bioorg Chem 72: 1-10 (2017)
Warsaw University Of Technology
Embarking on a Chemical Space Odyssey.EBI
J Med Chem 60: 3591-3593 (2017)
University Of Leeds
Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.EBI
J Med Chem 60: 3352-3371 (2017)
Roche Innovation Center Shanghai
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor.EBI
J Med Chem 60: 3070-3081 (2017)
University Of Southern California
Discovery of 4-((3'R,4'S,5'R)-6┐-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2┐-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3┐-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical DeveEBI
J Med Chem 60: 2819-2839 (2017)
University Of Michigan Comprehensive Cancer Center
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.EBI
J Med Chem 61: 462-481 (2018)
University Of Michigan Comprehensive Cancer Center
BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.EBI
ACS Med Chem Lett 8: 366-371 (2017)
Bristol-Myers Squibb
Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent.EBI
ACS Med Chem Lett 8: 344-349 (2017)
Dana-Farber Cancer Institute
Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.EBI
ACS Med Chem Lett 8: 338-343 (2017)
Novartis Institutes For Biomedical Research
Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.EBI
ACS Med Chem Lett 8: 333-337 (2017)
National Center For Scientific Research Demokritos
Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.EBI
ACS Med Chem Lett 8: 327-332 (2017)
Jinan University
Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.EBI
ACS Med Chem Lett 8: 321-326 (2017)
Global Blood Therapeutics
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.EBI
ACS Med Chem Lett 8: 316-320 (2017)
Takeda Pharmaceutical
Discovery and Assessment of Atropisomers of (▒)-Lesinurad.EBI
ACS Med Chem Lett 8: 299-303 (2017)
Wuxi Apptec
Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.EBI
ACS Med Chem Lett 8: 293-298 (2017)
Universit£
Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.EBI
ACS Med Chem Lett 8: 281-286 (2017)
Wayne State University
Bicyclic Ketone Sulfonamide Compounds.EBI
ACS Med Chem Lett 8: 278-280 (2017)
Temple University
Sodium Channel Blockers.EBI
ACS Med Chem Lett 8: 275-277 (2017)
Temple University
Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.EBI
Bioorg Med Chem 25: 2617-2624 (2017)
Nagoya City University
Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity.EBI
Bioorg Med Chem 25: 2666-2675 (2017)
Shandong University
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.EBI
Bioorg Med Chem Lett 27: 2023-2028 (2017)
Glaxosmithkline
Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site.EBI
Eur J Med Chem 132: 1-10 (2017)
Shenyang Pharmaceutical University
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.EBI
J Med Chem 60: 3198-3211 (2017)
University Of Massachusetts Medical School
Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.EBI
J Med Chem 60: 2963-2972 (2017)
National Center For Scientific Research Demokritos
The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture.EBI
J Nat Prod 80: 1150-1160 (2017)
University Of Illinois At Chicago
Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3K? inhibitors.EBI
Bioorg Med Chem Lett 27: 1972-1977 (2017)
Xi'An Jiaotong University
(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.EBI
Eur J Med Chem 131: 207-221 (2017)
Yachaytech University
Sulfonamides as Selective NaEBI
J Med Chem 60: 5990-6017 (2017)
Amgen
Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.EBI
J Med Chem 60: 3052-3069 (2017)
University Of Michigan
Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.BDB
ACS Chem Biol 12: 1346-1352 (2017)
Merck
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.EBI
J Nat Prod 80: 999-1006 (2017)
The Czech Academy Of Sciences
High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor.EBI
Bioorg Med Chem Lett 27: 2029-2037 (2017)
West Virginia University
Synthesis of conformationally restricted 1,3-dioxanes to analyze the bioactive conformation of 1,3-dioxane-based?EBI
Bioorg Med Chem 25: 2472-2481 (2017)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.EBI
J Med Chem 60: 3109-3123 (2017)
National Institute Of Diabetes And Digestive And Kidney Diseases
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17?-Hydroxysteroid Dehydrogenase Type 2.EBI
J Nat Prod 80: 965-974 (2017)
University Of Basel
Easy and rapid preparation of benzoylhydrazides and their diazene derivatives as inhibitors of 15-lipoxygenase.EBI
Bioorg Med Chem Lett 27: 1649-1653 (2017)
Universidad De Chile
Identification and structure activity relationships of quinoline tertiary alcohol modulators of ROR?t.EBI
Bioorg Med Chem Lett 27: 2047-2057 (2017)
Janssen Pharmaceutica
Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues.EBI
Bioorg Med Chem Lett 27: 1644-1648 (2017)
Medical University Of Lodz
Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism.EBI
Bioorg Med Chem 25: 2498-2506 (2017)
Gyeongsang National University
Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties.EBI
Bioorg Med Chem 25: 2524-2529 (2017)
Prince Sattam Bin Abdulaziz University
Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold.EBI
Bioorg Med Chem 25: 2399-2405 (2017)
Medical University Of Lodz
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor.EBI
Eur J Med Chem 131: 107-125 (2017)
University Of Science And Technology Of China
Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors.EBI
Bioorg Med Chem Lett 27: 1640-1643 (2017)
Wuhan Institute Of Technology
Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR.EBI
Bioorg Med Chem 25: 2491-2497 (2017)
Wuhan Institute Of Technology
Design, synthesis and biological evaluation of 7-methylimidazo[1,5-a]pyrazin-8(7H)-one derivatives as BRD4 inhibitors.EBI
Bioorg Med Chem 25: 2482-2490 (2017)
China Pharmaceutical University
Modulation of opioid receptor affinity and efficacy via N-substitution of 9?-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.EBI
Bioorg Med Chem 25: 2406-2422 (2017)
National Institute On Drug Abuse And The National Institute On Alcohol Abuse
t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.EBI
Bioorg Med Chem 25: 2451-2462 (2017)
Seoul National University
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.BDB
ACS Chem Biol 12: 1390-1396 (2017)
University Of Cambridge
Development of Potent and Selective Antagonists for the UTP-Activated P2YEBI
J Med Chem 60: 3020-3038 (2017)
University Of Bonn
Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.EBI
J Med Chem 60: 3703-3726 (2017)
University Of Liverpool
Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property.EBI
Bioorg Med Chem 25: 2387-2398 (2017)
China Pharmaceutical University
Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.EBI
Bioorg Med Chem 25: 2437-2444 (2017)
University Of Iowa
Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives.EBI
Bioorg Med Chem 25: 2336-2350 (2017)
Takeda Pharmaceutical
Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies.EBI
Bioorg Med Chem 25: 2351-2371 (2017)
University Of Karachi
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.EBI
Bioorg Med Chem 25: 2518-2523 (2017)
Universit£
Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii.EBI
Bioorg Med Chem Lett 27: 1705-1708 (2017)
University Of Georgia
Structure-based discovery of LpxC inhibitors.EBI
Bioorg Med Chem Lett 27: 1670-1680 (2017)
Cubist Pharmaceuticals
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains.EBI
Eur J Med Chem 131: 92-106 (2017)
Anadolu University
Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.EBI
J Med Chem 60: 2930-2943 (2017)
China Pharmaceutical University
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.EBI
J Med Chem 60: 3511-3517 (2017)
Janssen Research And Development
Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine DEBI
J Med Chem 60: 2890-2907 (2017)
National Institute On Drug Abuse-Intramural Research Program
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERa+ Breast Cancer.EBI
J Med Chem 60: 2790-2818 (2017)
Novartis Institutes For Biomedical Research
Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.EBI
J Nat Prod 80: 1161-1166 (2017)
Keio University
Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.EBI
Bioorg Med Chem Lett 27: 1709-1713 (2017)
Takeda California
Synthesis and evaluation of a ligand targeting the? and? opioid receptors for drug delivery to lung cancer.EBI
Bioorg Med Chem Lett 27: 2074-2078 (2017)
Purdue University
Synthesis and molecular docking studies of new furochromone derivatives as p38? MAPK inhibitors targeting human breast cancer MCF-7 cells.EBI
Bioorg Med Chem 25: 2423-2436 (2017)
Cairo University
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF-┐B Activity As Novel Anticancer Agents.EBI
J Med Chem 60: 2853-2868 (2017)
Saarland University
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1PEBI
J Med Chem 60: 5267-5289 (2017)
Bristol-Myers Squibb
Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders.EBI
Eur J Med Chem 131: 68-80 (2017)
Tripura University
Coumarin sulfonates: New alkaline phosphatase inhibitors; inávitro and in silico studies.EBI
Eur J Med Chem 131: 29-47 (2017)
University Of Karachi
In silico design of novel probes for the atypical opioid receptor MRGPRX2.BDB
Nat Chem Biol 13: 529-536 (2017)
University Of North Carolina
Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.EBI
J Med Chem 60: 2732-2744 (2017)
University Of Gdansk
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.EBI
J Med Chem 60: 3002-3019 (2017)
Wuxi Apptec
Sulfonamides as Selective NaEBI
J Med Chem 60: 5969-5989 (2017)
Amgen
Price for Opening the Transient Specificity Pocket in Human Aldose Reductase upon Ligand Binding: Structural, Thermodynamic, Kinetic, and Computational Analysis.BDB
ACS Chem Biol 12: 1397-1415 (2017)
Philipps-Universitńt Marburg
Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.EBI
J Med Chem 60: 2485-2497 (2017)
Roche Pharmaceutical Research And Early Development (Pred)
Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor.EBI
Eur J Med Chem 131: 14-28 (2017)
Guru Nanak Dev University
Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.EBI
Bioorg Med Chem 25: 5041-5049 (2017)
National Cancer Institute-Frederick
Design, synthesis and structure-activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker.EBI
Bioorg Med Chem 25: 2445-2450 (2017)
China Pharmaceutical University
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists.EBI
Bioorg Med Chem Lett 27: 1760-1764 (2017)
Janssen Research And Development
Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain.EBI
Bioorg Med Chem 25: 2177-2190 (2017)
Shionogi
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.EBI
Bioorg Med Chem 25: 2133-2147 (2017)
Takeda Pharmaceutical
Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.EBI
Bioorg Med Chem 25: 2260-2265 (2017)
Instituto De Qu£Mica Avanzada De Catalu£A (Iqac-Csic)
Investigation on cellular uptake and pharmacodynamics of DOCK2-inhibitory peptides conjugated with cell-penetrating peptides.EBI
Bioorg Med Chem 25: 2148-2155 (2017)
Takeda Pharmaceutical
Biological evaluation of pyridone alkaloids on the endocannabinoid system.EBI
Bioorg Med Chem 25: 6102-6114 (2017)
University Of Bern
Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.EBI
Bioorg Med Chem Lett 27: 2063-2068 (2017)
Merck
Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.EBI
Bioorg Med Chem Lett 27: 1727-1730 (2017)
University Of Paris
Novel 2-phenyl-4,5,6,7-tetrahydro[b]benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation, and molecular docking studies.EBI
Bioorg Med Chem Lett 27: 1721-1726 (2017)
Institute Of Chemical Technology
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.EBI
Bioorg Med Chem Lett 27: 2069-2073 (2017)
Merck
Development of 2, 4-diaminoquinazoline derivatives as potent PAK4 inhibitors by the core refinement strategy.EBI
Eur J Med Chem 131: 1-13 (2017)
Shenyang Pharmaceutical University
Discovery of selective ATP-competitive eIF4A3 inhibitors.EBI
Bioorg Med Chem 25: 2200-2209 (2017)
Takeda Pharmaceutical
Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.EBI
Bioorg Med Chem Lett 27: 1633-1639 (2017)
University Of Texas Medical Branch
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 130: 440-457 (2017)
Federal University Of Alfenas
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.EBI
J Med Chem 60: 2944-2962 (2017)
High Magnetic Field Laboratory
Non-kinase targets of protein kinase inhibitors.EBI
Nat Rev Drug Discov 16: 424-440 (2017)
The University Of Sydney
Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2XEBI
Eur J Med Chem 130: 433-439 (2017)
The University Of Sydney
Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors.EBI
Eur J Med Chem 130: 406-418 (2017)
Carna Biosciences
Design, synthesis, and biological evaluation of novel 4-anilinoquinazoline derivatives bearing amino acid moiety as potential EGFR kinase inhibitors.EBI
Eur J Med Chem 130: 393-405 (2017)
Xuzhou Medical University
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 130: 379-392 (2017)
Nanyang Normal University
Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity.EBI
Bioorg Med Chem 25: 2057-2064 (2017)
Persian Gulf University
Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation.EBI
Bioorg Med Chem 25: 2234-2243 (2017)
Daiichi Sankyo
Soluble epoxide hydrolase inhibitors of indolinone alkaloids and phenolic derivatives from Cimicifuga dahurica (Turcz.) Maxim.EBI
Bioorg Med Chem Lett 27: 1874-1879 (2017)
Chungnam National University
Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.EBI
Bioorg Med Chem Lett 27: 1867-1873 (2017)
Advinus Therapeutics
Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy.EBI
J Med Chem 60: 2780-2789 (2017)
University Of Aberdeen
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.EBI
J Med Chem 60: 2697-2717 (2017)
Shanghai Institute Of Materia Medica
Bortezomib inhibits mammalian carbonic anhydrases.EBI
Bioorg Med Chem 25: 5064-5067 (2017)
Universit£
Design, synthesis and in vitro activity of 1,4-disubstituted piperazines and piperidines as triple reuptake inhibitors.EBI
Bioorg Med Chem 25: 2266-2276 (2017)
Chonnam National University
Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2.EBI
Bioorg Med Chem 25: 2277-2284 (2017)
University Of Tartu
Identification of novel TACE inhibitors compatible with topical application.EBI
Bioorg Med Chem Lett 27: 1848-1853 (2017)
Nestl�
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.EBI
Bioorg Med Chem Lett 27: 1840-1847 (2017)
Gilead Sciences
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.EBI
Bioorg Med Chem Lett 27: 1826-1830 (2017)
Hanyang University
Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced intoá2-aryl-1,3,4-oxadiazin-5(6H)-one.EBI
Eur J Med Chem 130: 365-378 (2017)
Seoul National University
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.EBI
J Med Chem 60: 3154-3164 (2017)
Universit£
Discovery of new Syk inhibitors through structure-based virtual screening.EBI
Bioorg Med Chem Lett 27: 1776-1779 (2017)
Second Military Medical University
Chemical and bioactivity of flavanones obtained from roots of Dalea pazensis Rusby.EBI
Bioorg Med Chem Lett 27: 1789-1794 (2017)
Universidad Nacional De C£Rdoba
Methylpyrrole inhibitors of BET bromodomains.EBI
Bioorg Med Chem Lett 27: 2225-2233 (2017)
Abbvie
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.BDB
Bioorg Chem 71: 305-314 (2017)
Sichuan University
Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.EBI
J Med Chem 60: 3124-3153 (2017)
Lindsey F. Kimball Research Institute
Exploiting sp(2) -Hybridisation in the Development of Potent 1,5-a-l-Arabinanase Inhibitors.BDB
Chembiochem 18: 974-978 (2017)
University Of Western Australia
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.BDB
Cell Chem Biol 24: 371-380 (2017)
University Of Oxford
Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.BDB
Cell Chem Biol 24: 381-390 (2017)
The University Of Tokyo
Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation.EBI
Eur J Med Chem 130: 328-335 (2017)
Aristotle University Of Thessaloniki
Quinazoline derivatives as selective CYP1B1 inhibitors.EBI
Eur J Med Chem 130: 320-327 (2017)
Birla Institute Of Technology
Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.EBI
Bioorg Med Chem Lett 27: 1508-1512 (2017)
University Of Applied Sciences Darmstadt
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.EBI
Bioorg Med Chem 25: 2156-2166 (2017)
The Ohio State University
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy.EBI
Bioorg Med Chem 25: 2105-2132 (2017)
Washington University
Green synthesis, inhibition studies of yeast a-glucosidase and molecular docking of pyrazolylpyridazine amines.BDB
Bioorg Chem 71: 170-180 (2017)
University Of The Punjab
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.EBI
Bioorg Med Chem Lett 27: 1602-1607 (2017)
Duquesne University
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).EBI
J Med Chem 60: 3094-3108 (2017)
Pfizer
Original endomorphin-1 analogues exhibit good analgesic effects.EBI
Bioorg Med Chem Lett 27: 1557-1560 (2017)
The First Hospital Of Lanzhou University
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.EBI
Bioorg Med Chem 25: 2210-2217 (2017)
University Of Wollongong
Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin K antagonists.EBI
Bioorg Med Chem Lett 27: 1598-1601 (2017)
Universit£
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.EBI
Bioorg Med Chem Lett 27: 1576-1583 (2017)
Abbvie
Impact of androstane A- and D-ring inversion on 17▀-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability.EBI
Bioorg Med Chem 25: 2065-2073 (2017)
Chu De Qu£Bec-Research Center
Discovery of novel BTK inhibitors with carboxylic acids.EBI
Bioorg Med Chem Lett 27: 1471-1477 (2017)
Merck
Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.EBI
J Med Chem 60: 2456-2469 (2017)
University Of Delhi
Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.BDB
Chembiochem 18: 914-920 (2017)
University Of Illinois
Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.EBI
J Med Chem 60: 5235-5266 (2017)
Goethe-University Frankfurt
Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.EBI
J Med Chem 60: 3594-3605 (2017)
Merck
Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet?-cells from apoptosis.EBI
Eur J Med Chem 130: 195-208 (2017)
East China Normal University
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.EBI
J Med Chem 60: 2908-2929 (2017)
Friedrich-Alexander University Erlangen-N£Rnberg
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.EBI
Eur J Med Chem 130: 171-184 (2017)
University Of Ljubljana
Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents.EBI
Eur J Med Chem 130: 154-170 (2017)
Svkm'S Dr. Bhanuben Nanavati College Of Pharmacy
Synthesis of readily available fluorophenylalanine derivatives and investigation of their biological activity.BDB
Bioorg Chem 71: 244-256 (2017)
Charles University
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.EBI
J Med Chem 60: 2983-2992 (2017)
Merck
Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking.EBI
J Med Chem 60: 2718-2731 (2017)
The Ohio State University
Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.BDB
Nat Chem Biol 13: 486-493 (2017)
California Institute Of Technology
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The"Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.EBI
J Med Chem 60: 2605-2628 (2017)
Virginia Commonwealth University
Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.EBI
Eur J Med Chem 130: 86-106 (2017)
China Pharmaceutical University
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.EBI
Eur J Med Chem 130: 60-72 (2017)
Instituto De Qu£Mica M£Dica
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.EBI
Eur J Med Chem 130: 139-153 (2017)
Sun Yat-Sen University
Vicinal diaryl azole-based urea derivatives as potential cholesterol lowering agents acting through inhibition of SOAT enzymes.EBI
Eur J Med Chem 130: 107-123 (2017)
The Maharaja Sayajirao University Of Baroda
Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs).EBI
Bioorg Med Chem Lett 27: 1608-1610 (2017)
Torrey Pines Institute For Molecular Studies
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.EBI
J Med Chem 60: 4780-4804 (2017)
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.EBI
J Med Chem 60: 2344-2360 (2017)
University Of Bayreuth
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.EBI
J Nat Prod 80: 699-706 (2017)
University Of Athens
Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.BDB
Cell Chem Biol 24: 281-292 (2017)
University Of Colorado
Synthesis and in vitro biological evaluation of novel quinazoline derivatives.EBI
Bioorg Med Chem Lett 27: 1584-1587 (2017)
Key Laboratory Of The Ministry Of Education For Medicinal Resources And Natural Pharmaceutical Chemistry
Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine AEBI
Bioorg Med Chem 25: 1963-1975 (2017)
Advinus Therapeutics
Comparison of the anion inhibition profiles of the▀- and┐-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei.EBI
Bioorg Med Chem 25: 2010-2015 (2017)
Istituto Di Bioscienze E Biorisorse, Cnr
Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective? opioid receptor antagonists.EBI
Eur J Med Chem 130: 15-25 (2017)
China Pharmaceutical University
Continued optimization of the MEBI
Bioorg Med Chem Lett 27: 1356-1359 (2017)
Vanderbilt University School Of Medicine
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and▀-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.EBI
Bioorg Med Chem 25: 1997-2009 (2017)
Sichuan University
Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAEBI
Bioorg Med Chem 25: 1901-1906 (2017)
Universit£
Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds.EBI
Bioorg Med Chem 25: 1914-1925 (2017)
Saint Petersburg State University
Kinase-independent phosphoramidate S1PEBI
Bioorg Med Chem Lett 27: 1371-1378 (2017)
Cardiff University
Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.EBI
Bioorg Med Chem Lett 27: 1341-1345 (2017)
Soochow University
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.EBI
Bioorg Med Chem 25: 2901-2916 (2017)
Baylor University
Synthesis, molecular docking and biological evaluation of some newer 2-substituted-4-(benzo[d][1,3]dioxol-5-yl)-6-phenylpyridazin-3(2H)-ones as potential anti-inflammatory and analgesic agents.BDB
Bioorg Chem 71: 201-210 (2017)
Panjab University
Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.EBI
Eur J Med Chem 129: 303-309 (2017)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.EBI
Eur J Med Chem 129: 287-302 (2017)
University Of Torino
Design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine derivatives as mTOR inhibitors.EBI
Eur J Med Chem 129: 135-150 (2017)
Peking University
Development of New Benzenesulfonamides As Potent and Selective NaEBI
J Med Chem 60: 2513-2525 (2017)
Bristol-Myers Squibb
Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.EBI
J Med Chem 60: 2573-2590 (2017)
Seoul National University
Synthesis and biological evaluation of novel N3-substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain.EBI
Bioorg Med Chem 25: 1926-1938 (2017)
South Dakota State University
Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors.EBI
Bioorg Med Chem 25: 1939-1948 (2017)
Shandong University
Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.EBI
Eur J Med Chem 129: 275-286 (2017)
West China Hospital Of Sichuan University
Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition.EBI
Eur J Med Chem 129: 251-265 (2017)
Affiliated To Sardar Patel University
Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.EBI
J Med Chem 60: 2562-2572 (2017)
Pfizer
Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.EBI
J Med Chem 60: 2227-2244 (2017)
East China University Of Science And Technology
Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.EBI
J Med Chem 60: 2383-2400 (2017)
Forum Pharmaceuticals
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).EBI
J Med Chem 60: 2685-2696 (2017)
University Of California