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Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50049144
LigandPNGBDBM50121344(CHEMBL3622105 | US9751881, Example 3)
Affinity DataIC50:  10nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235202(CHEMBL4079335)
Affinity DataIC50:  10nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235201(CHEMBL4066423)
Affinity DataIC50:  10nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50:  10nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50:  29nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235197(CHEMBL4086237)
Affinity DataIC50:  34nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235196(CHEMBL4064760)
Affinity DataIC50:  37nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235196(CHEMBL4064760)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235198(CHEMBL4066256)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50:  41nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235198(CHEMBL4066256)
Affinity DataIC50:  43nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235196(CHEMBL4064760)
Affinity DataIC50:  44nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235199(CHEMBL4070123)
Affinity DataIC50:  47nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50391781(CHEMBL2146873 | US9073882, 38)
Affinity DataIC50:  49nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50:  50nMAssay Description:Inhibition of human ROMK expressed in CHO cells by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235198(CHEMBL4066256)
Affinity DataIC50:  53nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50:  60nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235197(CHEMBL4086237)
Affinity DataIC50:  60nMAssay Description:In vitro 100 nM cortex affinity to displace [3H]- -CD providing a measure of muscarinic m1 receptor agonist affinityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235197(CHEMBL4086237)
Affinity DataIC50:  74nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235211(CHEMBL4093830)
Affinity DataIC50:  76nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235208(CHEMBL4097359)
Affinity DataIC50:  89nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235207(CHEMBL4087753)
Affinity DataIC50:  104nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  110nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235210(CHEMBL4074870)
Affinity DataIC50:  127nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50116795(CHEMBL3612807)
Affinity DataIC50:  140nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50391781(CHEMBL2146873 | US9073882, 38)
Affinity DataIC50:  170nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235199(CHEMBL4070123)
Affinity DataIC50:  193nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50:  226nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235195(CHEMBL4087218)
Affinity DataIC50:  240nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235206(CHEMBL4105076)
Affinity DataIC50:  308nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235203(CHEMBL4068517)
Affinity DataIC50:  901nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235204(CHEMBL4089640)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235208(CHEMBL4097359)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50442600(CHEMBL2441437 | US9056859, 1)
Affinity DataIC50:  1.40E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235202(CHEMBL4079335)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235201(CHEMBL4066423)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50121344(CHEMBL3622105 | US9751881, Example 3)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235205(CHEMBL4067468)
Affinity DataIC50:  3.00E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235204(CHEMBL4089640)
Affinity DataIC50:  3.30E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235203(CHEMBL4068517)
Affinity DataIC50:  4.60E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235210(CHEMBL4074870)
Affinity DataIC50:  6.10E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235205(CHEMBL4067468)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235211(CHEMBL4093830)
Affinity DataIC50:  7.90E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235196(CHEMBL4064760)
Affinity DataIC50:  8.90E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235207(CHEMBL4087753)
Affinity DataIC50:  1.05E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235200(CHEMBL4098260)
Affinity DataIC50:  1.44E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235197(CHEMBL4086237)
Affinity DataIC50:  1.61E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50235198(CHEMBL4066256)
Affinity DataIC50:  1.74E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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