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Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50049238
TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM94507(2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopenta...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM36880(2,2'-THIOBIS(4,6-DICHLOROPHENOL) | 2,4-dichlor...)
Affinity DataIC50:  2.23E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM151585(US11739089, Compound Ketoconazole | US8987315, Ket...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50063753(CHEMBL12131 | Closantel | N-(5-chloro-4-((4-chloro...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM25759(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
Affinity DataIC50:  3.40E+3nMAssay Description:In vitro inhibition of geranylgeranyl-protein transferase type-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50325274(4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-e...)
Affinity DataIC50:  4.17E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50225293(CHEBI:5553 | Guanabenz | WY-8678)
Affinity DataIC50:  4.85E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM31775(Amudane | Fulvicin | Grisefuline | Griseofulvin)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataIC50:  7.95E+3nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50303912(2,2'-methylenebis(4-chlorophenol) | 3,3'-dichloro-...)
Affinity DataIC50:  8.41E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50237286(Acamylophenine | Acamylophenine HCl | Camylofin)
Affinity DataIC50:  9.12E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataIC50:  9.18E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50366613(DEXTROMETHORPHAN)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM112780(US8629135, SW-07)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50033110(ALFUZOSIN | CHEMBL709 | N-{3-[(4-amino-6,7-dimetho...)
Affinity DataIC50:  1.49E+4nMAssay Description:In vitro inhibition of farnesyl-protein transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50237287(Cloperastine | Cloperastine Fendizoate | Cloperast...)
Affinity DataIC50:  1.49E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50067133(1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-p...)
Affinity DataIC50:  1.55E+4nMAssay Description:Binding affinity in competition with [125I]NDP-MSH on recombinant melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM8958(10-(2-diethylaminopropyl)phenothiazine | CHEMBL120...)
Affinity DataIC50:  2.05E+4nMAssay Description:Binding affinity against alpha-L-fucosidase in bovine kidney was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  2.17E+4nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  5.07E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50017041((RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline | 1,2...)
Affinity DataIC50:  8.21E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM181119(US9138393, Cimetidine | US9144538, Cimetidine)
Affinity DataIC50:  1.49E+5nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of YM155 after 1 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50229665(1,1-Dimethylbiguanide | CHEMBL1431 | METFORMIN | N...)
Affinity DataIC50:  1.23E+6nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50373877(Betaxin | CA inhibitor, 3 | THIAMINE (VIT B1) | Th...)
Affinity DataIC50:  4.35E+6nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)