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Found 52 Enz. Inhib. hit(s) with all data for entry = 50000081
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240239(CHEMBL4090203)
Affinity DataIC50:  11nMAssay Description:In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240237(CHEMBL4079748)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240238(CHEMBL4076061)
Affinity DataIC50:  24nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  31nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  31nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  33nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240236(CHEMBL4097768)
Affinity DataIC50:  39nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240266(CHEMBL4084158)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240258(CHEMBL4064170)
Affinity DataIC50:  90nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240260(CHEMBL4084699)
Affinity DataIC50:  90nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240257(CHEMBL4073808)
Affinity DataIC50:  130nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240249(CHEMBL4068670)
Affinity DataIC50:  170nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240259(CHEMBL4102635)
Affinity DataIC50:  220nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240261(CHEMBL4092447)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240255(CHEMBL4086652)
Affinity DataIC50:  250nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240248(CHEMBL4060018)
Affinity DataIC50:  340nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  386nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240264(CHEMBL4072411)
Affinity DataIC50:  420nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240242(CHEMBL4074403)
Affinity DataIC50:  440nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240235(CHEMBL4091916)
Affinity DataIC50:  580nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240247(CHEMBL4095834)
Affinity DataIC50:  580nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240250(CHEMBL4089787)
Affinity DataIC50:  590nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240239(CHEMBL4090203)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240256(CHEMBL4065213)
Affinity DataIC50:  640nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240254(CHEMBL4093158)
Affinity DataIC50:  700nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240237(CHEMBL4079748)
Affinity DataIC50:  710nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240243(CHEMBL4073336)
Affinity DataIC50:  900nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240246(CHEMBL4068496)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240262(CHEMBL4081926)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240251(CHEMBL4097514)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240244(CHEMBL4100192)
Affinity DataIC50:  1.67E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240245(CHEMBL4064749)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240253(CHEMBL4105218)
Affinity DataIC50:  3.92E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240263(CHEMBL4079482)
Affinity DataIC50:  3.92E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240237(CHEMBL4079748)
Affinity DataIC50:  4.15E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240265(CHEMBL4094392)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240237(CHEMBL4079748)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240238(CHEMBL4076061)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240252(CHEMBL4087358)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240241(CHEMBL4094888)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.7 expressed in CHO-K1 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240259(CHEMBL4102635)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -120 mV holding potential incubated over 5 mins measured at 15 secs interval by Qpatch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240238(CHEMBL4076061)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240259(CHEMBL4102635)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240239(CHEMBL4090203)
Affinity DataIC50:  1.69E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50:  1.72E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240239(CHEMBL4090203)
Affinity DataIC50:  3.21E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240237(CHEMBL4079748)
Affinity DataIC50:  3.75E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240239(CHEMBL4090203)
Affinity DataIC50:  4.01E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240240(CHEMBL4102132)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50240237(CHEMBL4079748)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate preincubated for 10 mins followed by substrate addition measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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