Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 50049268
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237730(CHEMBL4074449)
Affinity DataIC50:  2nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237707(A-804598 | CHEMBL1628690)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237707(A-804598 | CHEMBL1628690)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Mus musculus)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237707(A-804598 | CHEMBL1628690)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237707(A-804598 | CHEMBL1628690)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237730(CHEMBL4074449)
Affinity DataIC50:  18nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237729(CHEMBL4088143)
Affinity DataIC50:  40nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237723(CHEMBL4089802)
Affinity DataIC50:  51nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237793(CHEMBL4070352)
Affinity DataIC50:  58nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake measured every 30 secs for 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237720(CHEMBL4092195)
Affinity DataIC50:  58nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237729(CHEMBL4088143)
Affinity DataIC50:  69nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237726(CHEMBL4070819)
Affinity DataIC50:  79nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237707(A-804598 | CHEMBL1628690)
Affinity DataIC50:  93nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237727(CHEMBL4060938)
Affinity DataIC50:  100nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237713(CHEMBL4071699)
Affinity DataIC50:  132nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237705(CHEMBL4063086)
Affinity DataIC50:  138nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237704(CHEMBL4099941)
Affinity DataIC50:  174nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of agonist-induced calcium flux pretreated for 3 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237719(CHEMBL4071403)
Affinity DataIC50:  186nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237718(CHEMBL4074136)
Affinity DataIC50:  214nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237705(CHEMBL4063086)
Affinity DataIC50:  234nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237706(CHEMBL4066859)
Affinity DataIC50:  389nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237706(CHEMBL4066859)
Affinity DataIC50:  389nMAssay Description:Antagonist activity at P2X7 receptor in LPS-stimulated human THP1 cells assessed as inhibition of LPS/BzATP-induced IL-1beta release preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237726(CHEMBL4070819)
Affinity DataIC50:  407nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake measured every 30 secs for 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237717(CHEMBL4100894)
Affinity DataIC50:  417nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237731(CHEMBL4092490)
Affinity DataIC50:  501nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237722(CHEMBL4097532)
Affinity DataIC50:  562nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237716(CHEMBL4101189)
Affinity DataIC50:  562nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237713(CHEMBL4071699)
Affinity DataIC50:  708nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake measured every 30 secs for 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237715(CHEMBL4065826)
Affinity DataIC50:  851nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of agonist-induced calcium flux pretreated for 3 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237708(CHEMBL4084743)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237728(CHEMBL4100383)
Affinity DataIC50:  2.46E+3nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237724(CHEMBL4061694)
Affinity DataIC50:  3.02E+3nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237725(CHEMBL4101328)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237703(CHEMBL4081414)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of agonist-induced calcium flux pretreated for 3 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237714(CHEMBL4093442)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237794(CHEMBL4074631)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced YO-PRO-1 Iodide uptake measured every 30 secs for 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237732(CHEMBL4081941)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50237795(CHEMBL4105673)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed