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Found 32 Enz. Inhib. hit(s) with all data for entry = 50049229
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236993(CHEMBL4086239)
Affinity DataEC50:  2.96E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237006(CHEMBL4083324)
Affinity DataEC50:  5.68E+3nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (isolated domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236995(CHEMBL4078375)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236996(CHEMBL4082365)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236997(CHEMBL4098862)
Affinity DataEC50:  290nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236998(CHEMBL4071870)
Affinity DataEC50:  6.08E+3nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236999(CHEMBL4077972)
Affinity DataEC50:  2.06E+3nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237000(CHEMBL4101738)
Affinity DataEC50:  380nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237001(CHEMBL4083747)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237002(CHEMBL4073356)
Affinity DataEC50:  590nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237003(CHEMBL4060463)
Affinity DataEC50:  990nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237004(CHEMBL4101321)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237005(CHEMBL4063237)
Affinity DataEC50:  160nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236993(CHEMBL4086239)
Affinity DataEC50:  9.36E+3nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236995(CHEMBL4078375)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237005(CHEMBL4063237)
Affinity DataEC50:  5.68E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237006(CHEMBL4083324)
Affinity DataEC50:  1.78E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237003(CHEMBL4060463)
Affinity DataEC50:  2.18E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236996(CHEMBL4082365)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236998(CHEMBL4071870)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237007(CHEMBL4102235)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (isolated domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236999(CHEMBL4077972)
Affinity DataEC50:  4.26E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237001(CHEMBL4083747)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237008(CHEMBL4094009)
Affinity DataEC50:  3.68E+4nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236994(CHEMBL4064764)
Affinity DataEC50:  1.18E+4nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237004(CHEMBL4101321)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (isolated domain)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236997(CHEMBL4098862)
Affinity DataEC50:  4.94E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237000(CHEMBL4101738)
Affinity DataEC50:  8.26E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237002(CHEMBL4073356)
Affinity DataEC50:  1.66E+4nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237007(CHEMBL4102235)
Affinity DataEC50:  4.49E+4nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50237008(CHEMBL4094009)
Affinity DataEC50:  760nMAssay Description:Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50236994(CHEMBL4064764)
Affinity DataEC50:  2.08E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed