Compile Data Set for Download or QSAR
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Found 43 Enz. Inhib. hit(s) with all data for entry = 50000996
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267227(CHEMBL4087914)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267233(CHEMBL4075212)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267248(CHEBI:2440 | CHEMBL488313)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267243(CHEMBL1984096)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267246(CHEMBL4069303)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267234(Acrofolione A)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267227(CHEMBL4087914)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267244(CHEMBL4077368)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267244(CHEMBL4077368)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267248(CHEBI:2440 | CHEMBL488313)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267246(CHEMBL4069303)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267233(CHEMBL4075212)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267248(CHEBI:2440 | CHEMBL488313)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267245(CHEMBL4078358)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267241(CHEMBL4080027)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267247(CHEMBL4101532)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267243(CHEMBL1984096)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267244(CHEMBL4077368)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267242(CHEMBL4096534)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267234(Acrofolione A)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267245(CHEMBL4078358)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267241(CHEMBL4080027)
Affinity DataIC50:  5.34E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267247(CHEMBL4101532)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267233(CHEMBL4075212)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267227(CHEMBL4087914)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267234(Acrofolione A)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267245(CHEMBL4078358)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267240(CHEMBL4104264)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267241(CHEMBL4080027)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267240(CHEMBL4104264)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267243(CHEMBL1984096)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267242(CHEMBL4096534)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267242(CHEMBL4096534)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267240(CHEMBL4104264)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267232(CHEMBL1241050)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267247(CHEMBL4101532)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50267246(CHEMBL4069303)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed