BDBM50357364 CHEMBL1242095

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c(-[#6](-[#6])=O)c1-[#8]

InChI Key InChIKey=RCOXTTLIGHDQHU-XYOKQWHBSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50357364   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of COX1 in human platelets assessed as inhibition of conversion of arachidonic acid to PGE2 preincubated for 15 mins before substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  420nMAssay Description:Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Universiti Putra Malaysia

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant COX2 expressed in insect Sf21 cells assessed as inhibition of conversion of arachidonic acid to PGE2 preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed