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Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50000639
TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataKi:  0.0730nMAssay Description:Non-competitive inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using varying levels of tyramine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataKi:  0.265nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256672(CHEMBL4078283)
Affinity DataKi:  0.741nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]U-69,593 from kappa opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256674(CHEMBL4086171)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256672(CHEMBL4078283)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256686(CHEMBL4064665)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256678(CHEMBL4093929)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256675(CHEMBL4073254)
Affinity DataKi:  29nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]U-69,593 from kappa opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256677(CHEMBL4101657)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256676(CHEMBL4083659)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]U-69,593 from kappa opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataKi:  161nMAssay Description:Displacement of [3H]DADLE from delta opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256674(CHEMBL4086171)
Affinity DataEC50:  797nMAssay Description:Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataEC50:  901nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataEC50:  761nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM21008((4S,7S,13S)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)pr...)
Affinity DataEC50:  368nMAssay Description:Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256672(CHEMBL4078283)
Affinity DataEC50:  253nMAssay Description:Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDelta-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataEC50:  630nMAssay Description:Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataEC50:  146nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256673(CHEMBL4102551)
Affinity DataEC50:  19nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256687(CHEMBL4065923)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256672(CHEMBL4078283)
Affinity DataEC50:  1.90nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataEC50:  0.740nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMu-type opioid receptor(Rat)
National Institute On Drug Abuse and The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256675(CHEMBL4073254)
Affinity DataEC50:  2.06E+3nMAssay Description:Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed