Compile Data Set for Download or QSAR
maximum 50k data
Found 54 Enz. Inhib. hit(s) with all data for entry = 50049302
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238549(CHEMBL4078091)
Affinity DataIC50:  330nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50:  330nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238591(CHEMBL4071851)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238542(CHEMBL4060448)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238546(CHEMBL4102308)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238543(CHEMBL4096718)
Affinity DataIC50:  530nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238547(CHEMBL4093573)
Affinity DataIC50:  830nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238602(CHEMBL4065013)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238593(CHEMBL4103903)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238600(CHEMBL4098309)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238603(CHEMBL4097311)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238544(CHEMBL4069130)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238601(CHEMBL4074067)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238545(CHEMBL4063223)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238534(CHEMBL4063156)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238550(CHEMBL4096147)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238594(CHEMBL4071771)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238553(CHEMBL1289144)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM33104((E)-3-[5-(2-nitrophenyl)-2-furanyl]-1-phenyl-2-pro...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238534(CHEMBL4063156)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238596(CHEMBL4094598)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238535(CHEMBL4060373)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238592(CHEMBL4070981)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238536(CHEMBL4082279)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238604(CHEMBL1290699)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238548(CHEMBL4085982)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50098047(CHEMBL3590214)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238595(CHEMBL4068547)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238551(CHEMBL4077572)
Affinity DataIC50:  8.70E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238538(CHEMBL4102895)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238598(CHEMBL1472767)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DOT1L (unknown origin) using biotinylated H3K79me2 as substrate preincubated for 15 mins followed by substrate/ SAM addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GCN5 (unknown origin) using H3 as substrate and Ac-CoA as cofactor preincubated for 10 mins followed by substrate/cofactor addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of BRD4 (unknown origin) using SGRG-K(Ac)-GG-K(Ac)-GLG-K-(Ac)-GGA-K(Ac)-RHRKVGG-K(Biotin) peptide as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SET7/9 (unknown origin) after 60 mins by Alpha LISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of NSD1 (unknown origin) preincubated for 15 mins followed by [3H]-SAM addition measured after 4 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 cell expression system using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238540(CHEMBL4092698)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli using of histone H3 as substrate preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length PRMT7 expressed in baculovirus using of histone H4 as substrate preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli using histone H4 as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238599(CHEMBL4086889)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238537(CHEMBL4074678)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238539(CHEMBL4084944)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 cell expression system using hi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM33104((E)-3-[5-(2-nitrophenyl)-2-furanyl]-1-phenyl-2-pro...)
Affinity DataIC50:  1.69E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238594(CHEMBL4071771)
Affinity DataIC50:  1.72E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50238605(CHEMBL4071261)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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