Compile Data Set for Download or QSAR
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Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50049294
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202784(US10245267, Example 131 | US10709712, Example 131 ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full-length BRAF (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202780(US10245267, Example 127 | US10709712, Example 127 ...)
Affinity DataEC50:  250nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202656(US10245267, Example 1 | US10709712, Example 1 | US...)
Affinity DataEC50:  80nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202770(US10245267, Example 117 | US10709712, Example 117 ...)
Affinity DataEC50:  76nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202791(US10245267, Example 138 | US10709712, Example 138 ...)
Affinity DataEC50:  460nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM77953(US10245267, Example 390 | US10709712, Example 390 ...)
Affinity DataEC50:  3.96E+3nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202787(US10245267, Example 134 | US10709712, Example 134 ...)
Affinity DataEC50:  300nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202798(US10245267, Example 145 | US10709712, Example 145 ...)
Affinity DataEC50:  80nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202784(US10245267, Example 131 | US10709712, Example 131 ...)
Affinity DataEC50:  20nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202784(US10245267, Example 131 | US10709712, Example 131 ...)
Affinity DataEC50:  100nMAssay Description:Inhibition of CRAF in human Calu6 cells assessed as decrease in ERK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase/Serine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataEC50:  601nMAssay Description:Stimulation of BRAF-CRAF dimerization in human HCT116 cells by luciferase complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetRAF proto-oncogene serine/threonine-protein kinase/Serine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202784(US10245267, Example 131 | US10709712, Example 131 ...)
Affinity DataEC50:  796nMAssay Description:Stimulation of BRAF-CRAF dimerization in human HCT116 cells by luciferase complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202716(US10245267, Example 62 | US10709712, Example 62 | ...)
Affinity DataEC50:  200nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM202772(US10245267, Example 119 | US10709712, Example 119 ...)
Affinity DataEC50:  200nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50237792(CHEMBL4081025)
Affinity DataEC50:  200nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50237798(CHEMBL4105276)
Affinity DataEC50:  700nMAssay Description:Inhibition CRAF in human Calu6 cells assessed as decrease in MEK phosphorylation after 2 hrs by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed