Compile Data Set for Download or QSAR
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Found 45 Enz. Inhib. hit(s) with all data for entry = 50000685
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of HCN2 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kv1.5 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInward rectifier potassium channel 2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258244(CHEMBL4100583)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258254(CHEMBL4073780)
Affinity DataEC50:  225nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258256(CHEMBL3427532)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258252(CHEMBL4073679)
Affinity DataEC50:  291nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258243(CHEMBL4081622)
Affinity DataEC50:  1.76E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258254(CHEMBL4073780)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258217(CHEMBL3427530)
Affinity DataEC50:  979nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258218(CHEMBL4103198)
Affinity DataEC50: >3.65E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258252(CHEMBL4073679)
Affinity DataEC50:  1.36E+3nMAssay Description:Inhibition of KCNQ1/minK (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258249(CHEMBL4080678)
Affinity DataEC50:  2.01E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258250(CHEMBL4104908)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258251(CHEMBL4072311)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258229(CHEMBL4103751)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258243(CHEMBL4081622)
Affinity DataEC50:  2.05E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258255(CHEMBL4062424)
Affinity DataEC50:  192nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258242(CHEMBL4071062)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258217(CHEMBL3427530)
Affinity DataEC50:  1.24E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258249(CHEMBL4080678)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258248(CHEMBL4084134)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258229(CHEMBL4103751)
Affinity DataEC50:  1.05E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258253(CHEMBL4085062)
Affinity DataEC50:  1.50E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258256(CHEMBL3427532)
Affinity DataEC50:  125nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258255(CHEMBL4062424)
Affinity DataEC50:  1.64E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258239(CHEMBL4091891)
Affinity DataEC50:  1.16E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  299nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258248(CHEMBL4084134)
Affinity DataEC50:  577nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258253(CHEMBL4085062)
Affinity DataEC50:  744nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50191342(3alpha-hydroxy-5alpha-pregnan-20-one | CHEMBL20753...)
Affinity DataEC50:  76nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258228(CHEMBL4078922)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Kv4.3(unknown origin)/KChIP2.2 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50191342(3alpha-hydroxy-5alpha-pregnan-20-one | CHEMBL20753...)
Affinity DataEC50:  237nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  375nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed