Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50000930
TargetTyrosine-protein kinase JAK3(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.184nMAssay Description:Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.351nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C alpha type(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.542nMAssay Description:Inhibition of human PKCa using histone H1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase SYK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.08nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase Lyn(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.39nMAssay Description:Inhibition of human LYN using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.58nMAssay Description:Inhibition of human PKACA using LCGRTGRRNSI as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  1.76nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase Yes(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.35nMAssay Description:Inhibition of human YES/YES1 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase Lck(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.68nMAssay Description:Inhibition of human LCK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProtein kinase C gamma type(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.76nMAssay Description:Inhibition of human PKCg using histone H1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  3.82nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5.94nMAssay Description:Inhibition of human AKT1 using KGSGSGRPRTSSFAEG as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ZAP-70(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  12.4nMAssay Description:Inhibition of human ZAP70 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase BTK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  18.1nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFocal adhesion kinase 1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human FAK/PTK2 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  20.3nMAssay Description:Inhibition of human CDK4/cyclinD1 using RB-CTF as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  45.8nMAssay Description:Inhibition of human MEK1 using ERK2 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase ABL1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  76nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human mTOR/FRAP1 using 4EBP1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetDual specificity protein kinase TTK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264841(CHEMBL4076767)
Affinity DataIC50:  356nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  581nMAssay Description:Inhibition of human JNK1 using ATF2 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase TTK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50053315(CHEMBL3330411)
Affinity DataIC50:  809nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFocal adhesion kinase 1(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264841(CHEMBL4076767)
Affinity DataIC50:  891nMAssay Description:Inhibition of human FAK/PTK2 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264841(CHEMBL4076767)
Affinity DataIC50:  1.67E+3nMAssay Description:Inhibition of human JNK1 using ATF2 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase TTK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM36485(1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrr...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetDual specificity protein kinase TTK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264842(CHEMBL4061742)
Affinity DataIC50:  3.42E+3nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein kinase TTK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264843(CHEMBL4091309)
Affinity DataIC50:  1.32E+4nMAssay Description:Inhibition of recombinant human GST-tagged Mps1/TTK (507 to 1400 residues) using recombinant cetn2 as substrate in presence of [gamma-32P]ATP measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50264841(CHEMBL4076767)
Affinity DataIC50:  4.06E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264841(CHEMBL4076767)
Affinity DataIC50:  1.32E+5nMAssay Description:Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase SYK(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50264841(CHEMBL4076767)
Affinity DataIC50:  1.54E+5nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed