BindingDB PrimarySearch

Found 14 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM2579'

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: <0.100nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair

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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 0.133nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 0.217nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 0.450nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: <1nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: <1nMAssay Description:Inhibition of SYK (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: <1nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 1.08nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 1.30nMAssay Description:Inhibition of SYK (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 1.30nMAssay Description:Inhibition of N-terminal GST-fused human recombinant full length SYK (1 to 635 residues) expressed in baculovirus-infected Sf21 cells using FAM-22 pe...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 60nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Kd: 14nMAssay Description:Binding constant for SYK kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Kd: 7nMAssay Description:Average Binding Constant for SYK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Kd: 14nMAssay Description:Binding constant for SYK kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

Filter my 14 hits

Targets 1▿
- Tyrosine-protein kinase SYK 14
Publications 14▿
- Eur J Med Chem 73: 167-76 (2014) 1
- Bioorg Med Chem 19: 6760-7 (2011) 1
- J Med Chem 52: 3191-204 (2009) 1
- Nat Biotechnol 26: 127-32 (2008) 1
- Eur J Med Chem 161: 456-467 (2019) 1
- Bioorg Med Chem 25: 2156-2166 (2017) 1
- Eur J Med Chem 141: 657-675 (2017) 1
- Eur J Med Chem 102: 600-10 (2015) 1
- Bioorg Med Chem 24: 3483-93 (2016) 1
- Eur J Med Chem 219: (2021) 1
- Nat Biotechnol 23: 329-36 (2005) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- Bioorg Med Chem 26: 1740-1750 (2018) 1
- Eur J Med Chem 221: (2021) 1
Institutions 11▿
- Ambit Biosciences 3
- Hanyang University 2
- University Of Florida 1
- Southeast University 1
- The Ohio State University 1
- Beijing Normal University 1
- University Of Chinese Academy Of Science 1
- National Cancer Institute-Bethesda 1
- Korea Institute Of Science And Technology (Kist) 1
- Zhejiang University 1
- Central University Of Punjab 1
Affinity: 0.10 to 60 nM▿
- IC50 11
- Kd 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 1
Catalog Cmpds: 1