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Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50000977
TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266867(CHEMBL4084676)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266855(CHEMBL4074716)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266856(CHEMBL4091547)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266851(CHEMBL4095906)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266866(CHEMBL4069602)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266853(CHEMBL4072067)
Affinity DataIC50:  56nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266850(CHEMBL4068589)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266865(CHEMBL4088012)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266868(CHEMBL4062140)
Affinity DataIC50:  302nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266852(CHEMBL4075294)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266868(CHEMBL4062140)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266856(CHEMBL4091547)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266841(CHEMBL4098347)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266850(CHEMBL4068589)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266854(CHEMBL4081499)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266853(CHEMBL4072067)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266867(CHEMBL4084676)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266852(CHEMBL4075294)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266851(CHEMBL4095906)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266866(CHEMBL4069602)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266843(CHEMBL4090622)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266842(CHEMBL4080317)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266865(CHEMBL4088012)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266854(CHEMBL4081499)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266842(CHEMBL4080317)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266841(CHEMBL4098347)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266855(CHEMBL4074716)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human COX-1 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50266843(CHEMBL4090622)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed