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Found 37 Enz. Inhib. hit(s) with all data for entry = 50001114
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of Her2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged BMX expressed in Sf21 cells preincubated for 5 mins followed by biotinyl-beta Abet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged YES expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  76nMAssay Description:Inhibition of BLK (unknown origin) preincubated for 5 mins followed by substrate addition after 30 to 60 mins in presence of ATP by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged BTK expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged RET (658 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  115nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged TEC (174 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  133nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged FGR (2 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  189nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MKK7beta (2 to end residues) expressed in Escherichia coli preincubated for 5 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  195nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged LCK expressed in Sf21 insect cells preincubated for 5 mins followed by substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  197nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged SRC expressed in Sf21 insect cells preincubated for 5 mins followed by substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  199nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged HCK (230 to 497 residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged BRK expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  312nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged LYN expressed in Sf21 insect cells preincubated for 5 mins followed by His-tagged ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  403nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged RIPK2 (1 to 299 residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged FYN expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  510nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged FRK (218 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  643nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (696 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  802nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ABL (27 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  883nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged TXK (256 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human N-terminal 6His-tagged HER4 (706 to 991 residues) preincubated for 5 mins followed by substrate addition after 30 to 60 mins in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of human C-terminal 6His-tagged Her2 (676 to end) expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by biotinyl-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  2.83E+3nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged CSK expressed in Escherichia coli BL21 (DE3) cells preincubated for 5 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  3.28E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in expressed in Sf21 cells preincubated for 5 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged FMS (538 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  5.66E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  5.91E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged FER (541 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50:  8.16E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged JAK3 (781 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged NEK2 expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RSK1 (unknown origin) preincubated for 5 mins followed by substrate addition after 30 to 60 mins in presence of ATP by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged SYK expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDGFRalpha expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by substrate addition after 30 to 60 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged JAK2 (808 to end residues) expressed in baculovirus Sf21 insect cells preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged PLK1 expressed in baculovirus Sf21 insect cells preincubated for 5 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human JAK1 expressed in baculovirus in Sf21 insect cells preincubated for 5 mins followed by substrate addition after 30 to 60 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed