Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50000157
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of BTK (unknown origin) preincubated for 1 hr followed by ATP addition measured after 1 hr by immobilized metal ion affinity-based fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human TEC using poly[Glu:Tyr] as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human BTK using KVEKIGEGTYGVVYK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 7nMAssay Description:Inhibition of TEC (unknown origin) after 2 hrs by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50: 8nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241732(CHEMBL4091764)
Affinity DataIC50: 18nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50: 44nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241731(CHEMBL4064000)
Affinity DataIC50: 77nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241733(CHEMBL4073371)
Affinity DataIC50: 106nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241730(CHEMBL4100228)
Affinity DataIC50: 137nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241732(CHEMBL4091764)
Affinity DataIC50: 153nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241733(CHEMBL4073371)
Affinity DataIC50: 271nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50: 306nMAssay Description:Inhibition of human TEC using poly[Glu:Tyr] as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241731(CHEMBL4064000)
Affinity DataIC50: 334nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241729(CHEMBL4079354)
Affinity DataIC50: 337nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241728(CHEMBL4103618)
Affinity DataIC50: 468nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human LYN using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241730(CHEMBL4100228)
Affinity DataIC50: 526nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50: 531nMAssay Description:Inhibition of His-tagged full length recombinant human LCK expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50: 600nMAssay Description:Inhibition of C-terminal His-tagged full length recombinant human FYN expressed in baculovirus expression system using TK-substrate-biotin after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241729(CHEMBL4079354)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241728(CHEMBL4103618)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241730(CHEMBL4100228)
Affinity DataIC50: 8.82E+3nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241729(CHEMBL4079354)
Affinity DataIC50: 9.22E+3nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241718(CHEMBL1354522)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of His-tagged full length recombinant human BMX expressed in baculovirus expression system using TK-substrate-biotin after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241719(CHEMBL4101977)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241728(CHEMBL4103618)
Affinity DataIC50: 2.71E+4nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241733(CHEMBL4073371)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241731(CHEMBL4064000)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Institute of Biological Sciences, Beijing

Curated by ChEMBL
LigandPNGBDBM50241732(CHEMBL4091764)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged p38alpha expressed in Escherichia coli BL21 DE3 using Ser/Thr-15 peptide as substrate after 60 mins by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed