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Found 30 Enz. Inhib. hit(s) with all data for entry = 50000019
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239258(CHEMBL4070727)
Affinity DataIC50:  1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239257(CHEMBL4071777)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239256(CHEMBL4082283)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239266(CHEMBL4092561)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239265(CHEMBL4073410)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239259(CHEMBL4097849)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239260(CHEMBL4090131)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239263(CHEMBL4063778)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239269(CHEMBL4101799)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239261(CHEMBL4065901)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239262(CHEMBL4091576)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239264(CHEMBL4083794)
Affinity DataIC50:  11nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239255(CHEMBL4076289)
Affinity DataIC50:  14nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239268(CHEMBL4093508)
Affinity DataIC50:  22nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239254(CHEMBL4070322)
Affinity DataIC50:  28nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239267(CHEMBL4062100)
Affinity DataIC50:  31nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50:  35nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50:  35nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239258(CHEMBL4070727)
Affinity DataIC50:  235nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataIC50:  265nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Affinity DataIC50:  392nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239255(CHEMBL4076289)
Affinity DataIC50:  453nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  629nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239254(CHEMBL4070322)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Haisco Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50239256(CHEMBL4082283)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed