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In vitro evaluation of potential bitterness-masking terpenoids from the Canada goldenrod (Solidago canadensis).EBI
J Nat Prod 77: 1739-43 (2014)
The Ohio State University
A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.EBI
J Nat Prod 77: 1753-7 (2014)
University of Oklahoma
Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2.EBI
J Med Chem 57: 6583-93 (2014)
Tokyo University of Pharmacy and Life Sciences
Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors.EBI
Eur J Med Chem 83: 617-29 (2014)
Universit£
Discovery of triazines as selective PDE4B versus PDE4D inhibitors.EBI
Bioorg Med Chem Lett 24: 4031-4 (2014)
Northern Illinois University
Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.EBI
Bioorg Med Chem Lett 24: 4019-22 (2014)
University of Utah
Synthesis and biological evaluation of 2,3'-diindolylmethanes as agonists of aryl hydrocarbon receptor.EBI
Bioorg Med Chem Lett 24: 4023-5 (2014)
University of Wisconsin
The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1).EBI
Bioorg Med Chem Lett 24: 3974-8 (2014)
The Scripps Research Institute
Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.EBI
Bioorg Med Chem 22: 3850-5 (2014)
University of Rajshahi
Structure-based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors.EBI
Bioorg Med Chem 22: 3871-8 (2014)
Yonsei University
Pyridopyrimidinone inhibitors of HIV-1 RNase H.EBI
Eur J Med Chem 83: 609-16 (2014)
Glaxosmithkline
Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents.EBI
Eur J Med Chem 83: 581-93 (2014)
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)
Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.EBI
Eur J Med Chem 83: 534-46 (2014)
Jagiellonian University Medical College
Identification, pharmacological evaluation and binding mode analysis of novel chromene and chromane baseds1 receptor ligands.EBI
Eur J Med Chem 83: 526-33 (2014)
University of Trieste
Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3K▀/d inhibitors for the treatment of PTEN-deficient tumours.EBI
Bioorg Med Chem Lett 24: 3928-35 (2014)
Astrazeneca
Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.EBI
J Nat Prod 77: 1644-9 (2014)
University of Hawaii At Manoa
Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor.EBI
J Med Chem 57: 5965-74 (2014)
University of Naples&Quot;Federico Ii&Quot
Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors.EBI
Eur J Med Chem 83: 466-73 (2014)
Wuhan University School of Pharmaceutical Sciences
A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.EBI
Eur J Med Chem 83: 455-65 (2014)
Universit£
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.EBI
Eur J Med Chem 83: 448-54 (2014)
Universiti Sains Malaysia
High affinity ligands and potent antagonists for thea1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives.EBI
Eur J Med Chem 83: 419-32 (2014)
Universit£
Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipasea anda/▀-hydrolase domain 6.EBI
J Med Chem 57: 6610-22 (2014)
Leiden University
Synthesis of some novel hydrazone and 2-pyrazoline derivatives: monoamine oxidase inhibitory activities and docking studies.EBI
Bioorg Med Chem Lett 24: 3278-84 (2014)
Ministry of Health of Turkey
Benzoquinones as inhibitors of botulinum neurotoxin serotype A.EBI
Bioorg Med Chem 22: 3971-81 (2014)
The Scripps Research Institute
Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.EBI
Bioorg Med Chem 22: 3989-93 (2014)
Tufts University
Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB2R selective benzimidazoles reveal unexpected intrinsic properties.EBI
Bioorg Med Chem 22: 3938-46 (2014)
Julius-Maximilians-Universit£T W£Rzburg
Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis.EBI
J Med Chem 57: 5893-903 (2014)
Leo Pharma
Development of first lead structures for phosphoinositide 3-kinase-C2┐ inhibitors.EBI
J Med Chem 58: 212-21 (2015)
Eberhard Karls University Tuebingen
Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.EBI
Eur J Med Chem 83: 398-408 (2014)
Minia University
Toward fluorescent probes for G-protein-coupled receptors (GPCRs).EBI
J Med Chem 57: 8187-203 (2014)
Shandong University
Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.EBI
Bioorg Med Chem 22: 4135-50 (2014)
Nerviano Medical Sciences
Synthesis ofa,▀-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid▀-induced cytotoxicity.EBI
Eur J Med Chem 83: 355-65 (2014)
Universiti Kebangsaan Malaysia
Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers.EBI
Eur J Med Chem 83: 344-54 (2014)
Csir-Indian Institute of Chemical Technology
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.EBI
Bioorg Med Chem Lett 24: 3255-9 (2014)
Universit£
Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.EBI
Bioorg Med Chem Lett 24: 3268-73 (2014)
Bristol-Myers Squibb
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: part II.EBI
Bioorg Med Chem Lett 24: 3238-42 (2014)
Glenmark Pharmaceuticals
Broad-spectrum allosteric inhibition of herpesvirus proteases.BDB
Biochemistry 53: 4648-60 (2014)
University of California San Francisco
Design of symmetrical and nonsymmetrical EBI
Medchemcomm 2013: 693-696 (2013)
Imperial College
Novel, potent and selective 17▀-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities.EBI
Eur J Med Chem 83: 317-37 (2014)
Saarland University
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.EBI
Eur J Med Chem 83: 294-306 (2014)
The Second People'S Hospital of Fujian Provinc
The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.EBI
Bioorg Med Chem Lett 24: 3285-90 (2014)
Novartis Institutes For Biomedical Research
Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.EBI
Bioorg Med Chem Lett 24: 3234-7 (2014)
Korea University
Pyrrolo- and pyridomorphinans: non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists.EBI
Bioorg Med Chem 22: 4067-72 (2014)
University of Bath
Targeting integrinsav▀3 anda5▀1 with new▀-lactam derivatives.EBI
Eur J Med Chem 83: 284-93 (2014)
University of Bologna
9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.EBI
Eur J Med Chem 83: 274-83 (2014)
Technische Universit£T Braunschweig
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.EBI
Eur J Med Chem 83: 256-73 (2014)
Jagiellonian University Medical College
Synthesis and evaluation of iminocoumaryl and coumaryl derivatized glycosides as galectin antagonists.EBI
Bioorg Med Chem Lett 24: 3516-20 (2014)
Lund University
Synthesis and biological evaluation ofa-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class ofa-glucosidase inhibitors.EBI
Bioorg Med Chem Lett 24: 3298-301 (2014)
Tohoku Pharmaceutical University
Effect of p-aminophenols on tyrosinase activity.EBI
Bioorg Med Chem 22: 3994-4000 (2014)
Hoshi University
Influence of azide incorporation on binding affinity by small papain inhibitors.EBI
Bioorg Med Chem 22: 5593-603 (2014)
Radboud University Nijmegen
Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.EBI
J Nat Prod 77: 1663-9 (2014)
University of Szeged
2-Hexylthio-▀,┐-CH2-ATP is an effective and selective NTPDase2 inhibitor.EBI
J Med Chem 57: 5919-34 (2014)
Bar-Ilan University
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.EBI
J Med Chem 57: 6210-25 (2014)
Universit£
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.EBI
J Med Chem 57: 6259-65 (2014)
Sapienza University of Rome
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.EBI
J Med Chem 57: 5975-85 (2014)
National Tsing Hua University
Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.EBI
Bioorg Med Chem Lett 24: 3302-6 (2014)
National Institute of Diabetes and Digestive and Kidney Diseases
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.EBI
Bioorg Med Chem Lett 24: 3307-14 (2014)
Vanderbilt University Medical Center
Diarylthiazole: an antimycobacterial scaffold potentially targeting PrrB-PrrA two-component system.EBI
J Med Chem 57: 6572-82 (2014)
Astrazeneca
Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.EBI
J Med Chem 57: 6128-40 (2014)
Astrazeneca
Chemical proteomics identifies heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as the molecular target of quercetin in its anti-cancer effects in PC-3 cells.BDB
J Biol Chem 289: 22078-89 (2014)
National Taiwan University
Discovery of novel inhibitors of vascular endothelial growth factor-A-Neuropilin-1 interaction by structure-based virtual screening.EBI
Bioorg Med Chem 22: 4042-8 (2014)
Universit£
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.EBI
Bioorg Med Chem Lett 24: 3641-6 (2014)
Vanderbilt University Medical Center
Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17▀-hydroxysteroid dehydrogenase 2 inhibitors.EBI
J Med Chem 57: 5995-6007 (2014)
University of Innsbruck
Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine.EBI
J Med Chem 57: 7838-58 (2014)
Merck Research Laboratories
Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp.EBI
J Nat Prod 77: 1749-52 (2014)
The University of Tokyo
Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.EBI
J Nat Prod 77: 1670-7 (2014)
Aichi Gakuin University
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).EBI
J Med Chem 57: 6060-82 (2014)
Astrazeneca
Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors.BDB
ACS Chem Biol 10: 279-88 (2015)
Technische Universit??????T Dortmund
i-Motif DNA: structure, stability and targeting with ligands.EBI
Bioorg Med Chem 22: 4407-18 (2014)
University of East Anglia
Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.EBI
J Nat Prod 77: 1594-600 (2014)
Institute of Chinese Materia Medica
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.EBI
J Med Chem 57: 6679-703 (2014)
University of Bonn
Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.EBI
Bioorg Med Chem 22: 4099-108 (2014)
Academy of Sciences of The Czech Republic
Synthesis and evaluation of salicylanilide derivatives as potential epidermal growth factor receptor inhibitors.BDB
Chem Biol Drug Des 85: 280-9 (2015)
Anhui University of Chinese Medicine
Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF).EBI
Bioorg Med Chem 22: 4124-34 (2014)
Freie Universit£T Berlin
Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors.EBI
Bioorg Med Chem 22: 4223-32 (2014)
Birla Institute of Technology & Science-Pilani
Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors.EBI
Bioorg Med Chem Lett 24: 3356-60 (2014)
Csir-Indian Institute of Chemical Technology
Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.EBI
Bioorg Med Chem Lett 24: 3464-8 (2014)
Amgen
Synthesis of bi-/tricyclic azasugars fused thiazinan-4-one and their HIV-RT inhibitory activity.EBI
Bioorg Med Chem Lett 24: 3426-9 (2014)
Hebei University
Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B.EBI
Bioorg Med Chem Lett 24: 3337-40 (2014)
Chonnam National University
Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.EBI
Bioorg Med Chem Lett 24: 3469-74 (2014)
The Institute of Cancer Research
A novel 2-oxoindolinylidene inhibitor of bacterial MurD ligase: Enzyme kinetics, protein-inhibitor binding by NMR and a molecular dynamics study.EBI
Eur J Med Chem 83: 92-101 (2014)
Slovenia National Institute of Chemistry
4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.EBI
Eur J Med Chem 83: 74-83 (2014)
Ocean University of China
Design, synthesis and evaluation of highly selective pyridone-based class II MET inhibitors.EBI
Bioorg Med Chem Lett 24: 3351-5 (2014)
Central China Normal University
Conformational analysis of an anti-androgenic, (E,E)-8-hydroxygermacrene B, using NOESY and dynamic NMR spectroscopy.EBI
Bioorg Med Chem Lett 24: 3526-9 (2014)
Naresuan University
Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3▀ of substituted quinolines.EBI
Bioorg Med Chem Lett 24: 3392-7 (2014)
Kansas State University
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties.EBI
Bioorg Med Chem Lett 24: 3341-5 (2014)
Bristol-Myers Squibb
2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2.EBI
J Med Chem 57: 6083-91 (2014)
University of Kentucky
Vascular L-type Ca▓┐ channel blocking activity of sulfur-containing indole alkaloids from Glycosmis petelotii.EBI
J Nat Prod 77: 1586-93 (2014)
Vietnam Academy of Science and Technology
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.EBI
J Med Chem 57: 5829-34 (2014)
Philipps-Universit£T Marburg
2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.EBI
Bioorg Med Chem Lett 24: 4039-43 (2014)
Seoul National University
Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists.EBI
Bioorg Med Chem Lett 24: 3385-8 (2014)
Florida Institute of Technology
Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells.EBI
Bioorg Med Chem Lett 24: 3373-6 (2014)
Riken
Design and optimization of highly-selective fungal CYP51 inhibitors.EBI
Bioorg Med Chem Lett 24: 3455-8 (2014)
Viamet Pharmaceuticals
Structure based virtual screening of MDPI database: discovery of structurally diverse and novel DPP-IV inhibitors.EBI
Bioorg Med Chem Lett 24: 3447-51 (2014)
Jamia Hamdard
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.EBI
Bioorg Med Chem Lett 24: 3422-5 (2014)
University of Perugia
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.EBI
Eur J Med Chem 83: 1-14 (2014)
Universit£
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.EBI
ACS Med Chem Lett 5: 717-21 (2014)
Merck Research Laboratories
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.EBI
ACS Med Chem Lett 5: 711-6 (2014)
Boehringer Ingelheim (Canada)
Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).EBI
ACS Med Chem Lett 5: 700-5 (2014)
Amgen
Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.EBI
ACS Med Chem Lett 5: 696-9 (2014)
National Institute On Drug Abuse-Intramural Research Program
Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.EBI
ACS Med Chem Lett 5: 690-5 (2014)
Merck Research Laboratories
Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand.EBI
ACS Med Chem Lett 5: 685-9 (2014)
Universit£
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.EBI
ACS Med Chem Lett 5: 679-84 (2014)
Biota Scientific Management
Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity.EBI
ACS Med Chem Lett 5: 673-8 (2014)
Shanghai Institute of Materia Medica
Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.EBI
ACS Med Chem Lett 5: 662-7 (2014)
Genentech
Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.EBI
ACS Med Chem Lett 5: 647-51 (2014)
National Institute On Drug Abuse-Intramural Research Program
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.EBI
ACS Med Chem Lett 5: 628-33 (2014)
Chinese National Center For Drug Screening
Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.EBI
ACS Med Chem Lett 5: 623-7 (2014)
Rti International
Imidazo[2,1]thiazol-3-one Derivatives Useful as Diagnostic Agents for Alzheimer's Disease.EBI
ACS Med Chem Lett 5: 619-20 (2014)
Temple University
Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction.BDB
Chembiochem 15: 1471-80 (2014)
University of Santiago De Compostela
Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies.EBI
Eur J Med Chem 81: 35-46 (2014)
University of Barcelona
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.EBI
J Med Chem 57: 5738-47 (2014)
Universitat De Barcelona
Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.EBI
Eur J Med Chem 82: 536-44 (2014)
Tehran University of Medical Sciences
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors.EBI
Bioorg Med Chem Lett 24: 3403-6 (2014)
National Health Research Institutes
Strategies for the modulation of phase II metabolism in a series of PKCe inhibitors.EBI
Bioorg Med Chem Lett 24: 3398-402 (2014)
Vertex Pharmaceuticals
2-(Hetero(aryl)methylene)hydrazine-1-carbothioamides as potent urease inhibitors.BDB
Chem Biol Drug Des 85: 225-30 (2015)
Quaid-I-Azam University
Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept.EBI
Bioorg Med Chem 22: 4162-76 (2014)
Aska Pharmaceutical
Pharmacological evaluation and docking studies ofa,▀-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines.EBI
Bioorg Med Chem 22: 4151-61 (2014)
Universiti Kebangsaan Malaysia
Development of second generation EP2 antagonists with high selectivity.EBI
Eur J Med Chem 82: 521-35 (2014)
Emory University
GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.EBI
J Med Chem 57: 5935-48 (2014)
Astrazeneca
Radioiodinated benzyloxybenzene derivatives: a class of flexible ligands target to ?-amyloid plaques in Alzheimer's brains.EBI
J Med Chem 57: 6030-42 (2014)
Beijing Normal University
Discovery of tetrahydroisoquinoline-based CXCR4 antagonists.EBI
ACS Med Chem Lett 4: 1025-30 (2013)
Emory University
Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor.EBI
ACS Med Chem Lett 3: 620-625 (2012)
TBA
The ?-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing.EBI
ACS Med Chem Lett 3: 265-7 (2012)
University of Pennsylvania
Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist.EBI
ACS Med Chem Lett 3: 985-990 (2012)
TBA
Discovery of Novel a4▀2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening.EBI
ACS Med Chem Lett 2: 855-860 (2011)
TBA
Discovery of Potent Dual PPARa Agonists/CB1 Ligands.EBI
ACS Med Chem Lett 2: 793-797 (2011)
TBA
The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.BDB
J Biol Chem 289: 21651-62 (2014)
Astrazeneca R&D Boston
Coumarin hybrids as novel therapeutic agents.EBI
Bioorg Med Chem 22: 3806-14 (2014)
Punjabi University
Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma.EBI
Bioorg Med Chem 22: 4109-18 (2014)
Second Affiliated Hospital of Southeast University
Diphenylpyrroles: Novel p53 activators.EBI
Eur J Med Chem 82: 472-9 (2014)
Cairo University
Tyrosinase inhibitory activity of a glucosylated hydroxystilbene in mouse melan-a melanocytes.EBI
J Nat Prod 77: 1270-4 (2014)
The Chinese University of Hong Kong
Synthesis and evaluation of three structurally related╣8F-labeled orvinols of different intrinsic activities: 6-O-[╣8F]fluoroethyl-diprenorphine ([╣8F]FDPN), 6-O-[╣8F]fluoroethyl-buprenorphine ([╣8F]FBPN), and 6-O-[╣8F]fluoroethyl-phenethyl-orvinol ([╣8F]FPEO).EBI
J Med Chem 57: 5464-9 (2014)
University of Oslo
Discovery of 4-aryl-7-hydroxyindoline-based P2Y1 antagonists as novel antiplatelet agents.EBI
J Med Chem 57: 6150-64 (2014)
Bristol-Myers Squibb Research
Synthesis and evaluation of N6-substituted apioadenosines as potential adenosine A3 receptor modulators.EBI
Bioorg Med Chem 22: 4257-68 (2014)
Ghent University
Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.BDB
Chem Biol 21: 782-91 (2014)
University of California San Diego
Synthesis of new melatoninergic hexahydroindenopyridines.EBI
Bioorg Med Chem Lett 24: 3534-6 (2014)
Universidad De Valencia
Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38a MAPK, CK1d and JAK2 kinase inhibitors.EBI
Bioorg Med Chem Lett 24: 3412-8 (2014)
Syncom
Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity.EBI
Eur J Med Chem 82: 418-25 (2014)
Universidade De S£O Paulo (Usp)
Inhibition of 17▀-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.EBI
Eur J Med Chem 82: 394-406 (2014)
Saarland University
Design, synthesis and pharmacological evaluation of novel substituted quinoline-2-carboxamide derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents.EBI
Eur J Med Chem 82: 385-93 (2014)
Nirma University
Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein.EBI
Bioorg Med Chem Lett 24: 3480-5 (2014)
The University of Tokyo
New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.EBI
J Med Chem 57: 5748-63 (2014)
Pharmaleads
Polyketides from the cultured lichen mycobiont of a Vietnamese Pyrenula sp.EBI
J Nat Prod 77: 1404-12 (2014)
Kobe Pharmaceutical University
Synthesis and evaluation of a new series of 3,5-bis((5-bromo-6-methyl-2-t-aminopyrimidin-4-yl)thio)-4H-1,2,4-triazol-4-amines and their cyclized products 'pyrimidinylthio pyrimidotriazolothiadiazines' as 15- lipo-oxygenase inhibitors.BDB
Chem Biol Drug Des 85: 216-24 (2015)
Ferdowsi University of Mashhad
Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes.EBI
Bioorg Med Chem 22: 4293-7 (2014)
University of California
Discovery and structure-activity relationship of novel 2,3-dihydrobenzofuran-7-carboxamide and 2,3-dihydrobenzofuran-3(2H)-one-7-carboxamide derivatives as poly(ADP-ribose)polymerase-1 inhibitors.EBI
J Med Chem 57: 5579-601 (2014)
St. John'S University
Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: a versatile architecture for CB2 selective ligands.EBI
Eur J Med Chem 82: 281-92 (2014)
Universit£
Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold.BDB
Bioorg Chem 16-26 (2014)
Ain Shams University
Dose-dependent inhibition of BACE-1 by the monoterpenoid 2,3,4,4-tetramethyl-5-methylenecyclopent-2-enone in cellular and mouse models of Alzheimer's disease.EBI
J Nat Prod 77: 1275-9 (2014)
University of Coimbra
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.EBI
J Med Chem 57: 5638-48 (2014)
University Jena
Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.EBI
J Med Chem 57: 5714-27 (2014)
Genentech
Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.EBI
J Med Chem 57: 5792-9 (2014)
The Scripps Research Institute
Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.EBI
J Med Chem 57: 6105-15 (2014)
Takeda Pharmaceutical
Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits.BDB
J Biol Chem 289: 21153-62 (2014)
Weizmann Institute of Science
Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2.EBI
Bioorg Med Chem 22: 4323-37 (2014)
Astellas Pharma
Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors.EBI
Bioorg Med Chem 22: 4285-92 (2014)
Nanjing University
Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity.EBI
J Med Chem 57: 5112-28 (2014)
Peking University
Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors.EBI
Eur J Med Chem 82: 274-80 (2014)
E£Tv£S Lor£Nd University (Elte)
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.EBI
J Med Chem 57: 5702-13 (2014)
Astrazeneca
Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).EBI
J Med Chem 57: 5620-37 (2014)
Vanderbilt University Medical Center
Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain.EBI
J Med Chem 57: 5800-16 (2014)
Merck Research Laboratories
Development of CBAP-BPyne, a probe for ?-secretase and presenilinase.EBI
Medchemcomm 5: 338-341 (2014)
Memorial Sloan-Kettering Cancer Center
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.EBI
Bioorg Med Chem 22: 4233-45 (2014)
Kurukshetra University
Pyridine analogues of spirocyclics1 receptor ligands.EBI
Bioorg Med Chem 22: 4277-84 (2014)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.EBI
Bioorg Med Chem Lett 24: 3609-13 (2014)
Merck Research Laboratories
Elements and modulation of functional dynamics.EBI
J Med Chem 57: 7819-37 (2014)
Janssen Research and Development
Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry.EBI
J Nat Prod 77: 1351-8 (2014)
University of North Carolina At Greensboro
Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.EBI
J Med Chem 57: 5764-76 (2014)
Mcgill University
Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P1 agonists.EBI
Bioorg Med Chem 22: 4246-56 (2014)
Daiichi Sankyo
Synthesis, biological evaluation and molecular modeling of 1,3,4-thiadiazol-2-amide derivatives as novel antitubulin agents.EBI
Bioorg Med Chem 22: 4312-22 (2014)
Nanjing University
Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists.EBI
Bioorg Med Chem 22: 4298-311 (2014)
Glaxosmithkline
Rational design of the first difluorostatone-based PfSUB1 inhibitors.EBI
Bioorg Med Chem Lett 24: 3582-6 (2014)
University of Siena
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase.EBI
Bioorg Med Chem Lett 24: 3618-21 (2014)
N.D. Zelinsky Institute of Organic Chemistry
Guanidine-baseda2-adrenoceptor ligands: Towards selective antagonist activity.EBI
Eur J Med Chem 82: 242-54 (2014)
Trinity College
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.EBI
Bioorg Med Chem Lett 24: 3104-7 (2014)
Glaxosmithkline
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.EBI
Bioorg Med Chem 22: 3670-83 (2014)
Chinese Academy of Sciences
Efficient modulation of ?-aminobutyric acid type A receptors by piperine derivatives.EBI
J Med Chem 57: 5602-19 (2014)
University of Vienna
Design ofa7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [(18)F] quinuclidine derivative.EBI
Eur J Med Chem 82: 214-24 (2014)
Universit£
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies.EBI
Eur J Med Chem 82: 164-71 (2014)
Sapienza University of Rome
Synthesis and in vivo SAR study of indolin-2-one-based multi-targeted inhibitors as potential anticancer agents.EBI
Eur J Med Chem 82: 139-51 (2014)
Qilu Pharmaceutical
Structural basis for low-affinity binding of non-R2 carboxylate-substituted tricyclic quinoline analogs to CK2a: comparative molecular dynamics simulation studies.BDB
Chem Biol Drug Des 85: 189-200 (2015)
Beijing University of Technology
Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.BDB
Chem Biol Drug Des 85: 181-8 (2015)
Shandong University
Endiandric acid analogues from Beilschmiedia ferruginea as dual inhibitors of Bcl-xL/Bak and Mcl-1/Bid interactions.EBI
J Nat Prod 77: 1430-7 (2014)
Institut De Chimie Des Substances Naturelles (Icsn)
4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.EBI
J Med Chem 57: 5190-202 (2014)
National Institutes of Health
Recent developments in novel antidepressants targetinga4▀2-nicotinic acetylcholine receptors.EBI
J Med Chem 57: 8204-23 (2014)
University of Illinois At Chicago
Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.EBI
ACS Med Chem Lett 5: 609-14 (2014)
Merck Research Laboratories
Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors.EBI
ACS Med Chem Lett 5: 592-7 (2014)
Chinese Academy of Sciences
Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues.EBI
ACS Med Chem Lett 5: 582-6 (2014)
Nagoya University
Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.EBI
ACS Med Chem Lett 5: 576-81 (2014)
Australian National University
Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor.EBI
ACS Med Chem Lett 5: 572-5 (2014)
Merck Research Laboratories
Himbacine-derived thrombin receptor antagonists: c7-spirocyclic analogues of vorapaxar.EBI
ACS Med Chem Lett 5: 561-5 (2014)
Merck Research Laboratories
Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists.EBI
ACS Med Chem Lett 5: 550-5 (2014)
Universit£
Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.EBI
ACS Med Chem Lett 5: 544-9 (2014)
Merck Research Laboratories
Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction.EBI
ACS Med Chem Lett 5: 538-43 (2014)
Astrazeneca
New Hits as Antagonists of GPR103 Identified by HTS.EBI
ACS Med Chem Lett 5: 527-32 (2014)
Astrazeneca
Optimization of GPR40 Agonists for Type 2 Diabetes.EBI
ACS Med Chem Lett 5: 517-21 (2014)
Amgen
2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation.EBI
ACS Med Chem Lett 5: 512-6 (2014)
National Institute of Pharmaceutical Education and Research (NIPER)
Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.EBI
ACS Med Chem Lett 5: 506-11 (2014)
Second Military Medical University
Biarylmethoxy Nicotinamides As Novel and Specific Inhibitors of Mycobacterium tuberculosis.EBI
ACS Med Chem Lett 5: 491-5 (2014)
Alkem Laboratories
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.EBI
ACS Med Chem Lett 5: 480-4 (2014)
Duquesne University
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.EBI
ACS Med Chem Lett 5: 474-9 (2014)
Pfizer
Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation.EBI
ACS Med Chem Lett 5: 462-7 (2014)
Virginia Commonwealth University
Fused Thiazin-3-ones as KCa3.1 Inhibitors.EBI
ACS Med Chem Lett 5: 460-1 (2014)
Temple University
Treatment of Immunological or Inflammatory Disorders with ITK Kinase Inhibitors.EBI
ACS Med Chem Lett 5: 456-7 (2014)
Therachem Research Medilab (India)
3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors.EBI
ACS Med Chem Lett 5: 428-33 (2014)
F. Hoffmann-La Roche
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.EBI
ACS Med Chem Lett 5: 422-7 (2014)
Boehringer Ingelheim (Canada)
Discovery of AZD3199, An Inhaled Ultralong Acting?2 Receptor Agonist with Rapid Onset of Action.EBI
ACS Med Chem Lett 5: 416-21 (2014)
Astrazeneca
Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.EBI
ACS Med Chem Lett 5: 405-10 (2014)
Weill Cornell Medical College
C-ring cannabinoid lactones: a novel cannabinergic chemotype.EBI
ACS Med Chem Lett 5: 400-4 (2014)
Northeastern University
Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists.EBI
ACS Med Chem Lett 5: 384-9 (2014)
Amgen
Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2.EBI
ACS Med Chem Lett 5: 378-83 (2014)
Constellation Pharmaceuticals
Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.EBI
ACS Med Chem Lett 5: 373-7 (2014)
Latvian Institute of Organic Synthesis
Novel delta opioid receptor agonists with oxazatricyclodecane structure.EBI
ACS Med Chem Lett 5: 368-72 (2014)
Kitasato University
Structure-Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry.EBI
ACS Med Chem Lett 5: 363-7 (2014)
University of California
Enhancing a CH-? Interaction to Increase the Affinity for 5-HT1A Receptors.EBI
ACS Med Chem Lett 5: 358-62 (2014)
University of Li£Ge
Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.EBI
ACS Med Chem Lett 5: 346-51 (2014)
Vanderbilt University Department of Chemistry
Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.EBI
ACS Med Chem Lett 5: 340-5 (2014)
Merck Research Laboratories
Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17.EBI
ACS Med Chem Lett 5: 326-30 (2014)
University of Bonn
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning.EBI
ACS Med Chem Lett 5: 309-14 (2014)
Chugai Pharmaceutical
Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities.EBI
ACS Med Chem Lett 5: 304-8 (2014)
State Key Laboratory of Drug Research
Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors.EBI
ACS Med Chem Lett 5: 298-303 (2014)
Vichem Chemie Research
Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.EBI
ACS Med Chem Lett 5: 293-7 (2014)
University of Copenhagen
Inhibitors of Factor XIa and Plasma Kallikrein May Treat Thromboembolic Disorders and Many Diabetes Complications.EBI
ACS Med Chem Lett 5: 286-7 (2014)
Therachem Research Medilab (India)
Selective 5-HT Receptor Modulators May Deliver Focused Targeting with Fewer Adverse Effects.EBI
ACS Med Chem Lett 5: 284-5 (2014)
Therachem Research Medilab (India)
Triazolo[4,5-d]pyrimidine Derivatives as Inhibitors of GCN2.EBI
ACS Med Chem Lett 5: 282-3 (2014)
Dart Neuroscience
Novel cycloalkenepyrazoles as inhibitors of bub1 kinase.EBI
ACS Med Chem Lett 5: 280-1 (2014)
Dart Neuroscience
Phenyl carboxamide analogues as spleen tyrosine kinase (syk) inhibitors.EBI
ACS Med Chem Lett 5: 278-9 (2014)
Dart Neuroscience
Thiazolocarboxamide Analogues as NAMPT Inhibitors.EBI
ACS Med Chem Lett 5: 277-277 (2014)
Dart Neuroscience
Quinoline Derivatives as 5-HT6 Receptor PET Ligands.EBI
ACS Med Chem Lett 5: 275-6 (2014)
Dart Neuroscience
Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.EBI
ACS Med Chem Lett 5: 264-9 (2014)
Merck Research Laboratories
Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.EBI
ACS Med Chem Lett 5: 255-8 (2014)
Seoul National University
Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2-P1' Region.EBI
ACS Med Chem Lett 5: 249-54 (2014)
Uppsala University
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.EBI
ACS Med Chem Lett 5: 205-9 (2014)
Abbvie
Small Macrocycles As Highly Active Integrin?2?1 Antagonists.EBI
ACS Med Chem Lett 5: 193-8 (2014)
Sanofi R & D
Inhibitors of factor d may provide a treatment for age-related macular degeneration.EBI
ACS Med Chem Lett 5: 106-7 (2014)
Therachem Research Medilab (India)
Selective EP4 Antagonist May Be Useful in Treating Arthritis and Arthritic Pain.EBI
ACS Med Chem Lett 5: 104-5 (2014)
Therachem Research Medilab (India)
Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.EBI
ACS Med Chem Lett 5: 188-92 (2014)
Bristol-Myers Squibb R & D
Himbacine-derived thrombin receptor antagonists: c7-aminomethyl and c9a-hydroxy analogues of vorapaxar.EBI
ACS Med Chem Lett 5: 183-7 (2014)
Merck Research Laboratories
Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action.EBI
ACS Med Chem Lett 5: 172-7 (2014)
University of Basel
FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.EBI
ACS Med Chem Lett 5: 166-71 (2014)
Astrazeneca
Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone.EBI
ACS Med Chem Lett 5: 158-61 (2014)
Universit£
Neutral ?-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA.EBI
ACS Med Chem Lett 5: 154-7 (2014)
Wesleyan University
Crystal Structures of PI3K? Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.EBI
ACS Med Chem Lett 5: 138-42 (2014)
Shanghai Jiao Tong University
Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7.EBI
ACS Med Chem Lett 5: 128-32 (2014)
Universidade Federal Do Abc
Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.EBI
ACS Med Chem Lett 5: 124-7 (2014)
Roche Pharma Research
Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist.EBI
ACS Med Chem Lett 5: 119-23 (2014)
Lundbeck Research Usa
(S)-N-Methyldihydroquinazolinones are the Active Enantiomers of Retro-2 Derived Compounds against Toxins.EBI
ACS Med Chem Lett 5: 94-7 (2014)
Cea
Evaluation of aminohydantoins as a novel class of antimalarial agents.EBI
ACS Med Chem Lett 5: 89-93 (2014)
Saint Louis University
Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.EBI
ACS Med Chem Lett 5: 78-83 (2014)
Array Biopharma
Discovery of Tertiary Amine and Indole Derivatives as Potent ROR?t Inverse Agonists.EBI
ACS Med Chem Lett 5: 65-8 (2014)
Glaxosmithkline
Novel Indole-N-glucoside, TA-1887 As a Sodium Glucose Cotransporter 2 Inhibitor for Treatment of Type 2 Diabetes.EBI
ACS Med Chem Lett 5: 51-5 (2014)
Mitsubishi Tanabe Pharma
Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors.EBI
ACS Med Chem Lett 5: 18-22 (2014)
University of Oulu
Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.EBI
ACS Med Chem Lett 5: 12-7 (2014)
National Center For Advancing Translational Sciences
Tankyrase inhibitors: potential treatment of hyperproliferative diseases.EBI
ACS Med Chem Lett 5: 10-1 (2014)
Therachem Research Medilab (India)
Inhibitors of Tropomyosin-Receptor Kinases (Trk's): Potential Pain Therapy and More.EBI
ACS Med Chem Lett 5: 8-9 (2014)
Therachem Research Medilab (India)
Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity.EBI
ACS Med Chem Lett 4: 875-9 (2013)
University of Camerino
[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.EBI
ACS Med Chem Lett 4: 863-8 (2013)
Merck Research Labortories
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.EBI
ACS Med Chem Lett 4: 835-40 (2013)
Constellation Pharmaceuticals
Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.EBI
ACS Med Chem Lett 4: 829-34 (2013)
Amgen
Gamma secretase modulators.EBI
ACS Med Chem Lett 4: (2013)
Montclair State University
Substituted Benzylspiroindolin-2-one Analogues as Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M1.EBI
ACS Med Chem Lett 4: (2013)
Montclair State University
Trisubstituted imidazoles as positive modulators of metabotropic glutamate receptor subtype 5.EBI
ACS Med Chem Lett 4: 819-21 (2013)
Dart Neuroscience
Inhibitors of PI3K? as Potential Treatment for Cancer.EBI
ACS Med Chem Lett 4: 815-6 (2013)
Therachem Research Medilab (India)
Aminopyridyl/Pyrazinyl Spiro[indoline-3,4'-piperidine]-2-ones As Highly Selective and Efficacious c-Met/ALK Inhibitors.EBI
ACS Med Chem Lett 4: 806-10 (2013)
Southern Medical University
Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.EBI
ACS Med Chem Lett 4: 800-5 (2013)
Astrazeneca
Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics.EBI
ACS Med Chem Lett 4: 795-9 (2013)
Universit£
Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.EBI
ACS Med Chem Lett 4: 790-4 (2013)
Daiichi Sankyo
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.EBI
ACS Med Chem Lett 4: 773-8 (2013)
Merck Research Laboratories
Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery.EBI
ACS Med Chem Lett 4: 768-72 (2013)
Sanofi-Aventis
Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.EBI
ACS Med Chem Lett 4: 757-61 (2013)
University of Connecticut
Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors.EBI
ACS Med Chem Lett 4: 742-6 (2013)
Astrazeneca
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-kB ActivationEBI
ACS Med Chem Lett 4: 730-5 (2013)
Riken
Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release.EBI
ACS Med Chem Lett 4: 704-9 (2013)
University of Cambridge
Histone Deacetylase 4 (HDAC4) Inhibitors: A Promising Treatment for Huntington's Disease.EBI
ACS Med Chem Lett 4: 692-3 (2013)
Therachem Research Medilab (India)
Inhibitors of ATR Kinase for Treatment of Cancer.EBI
ACS Med Chem Lett 4: 688-9 (2013)
Therachem Research Medilab (India)
Synthesis of 2?-heteroarylalkyl active vitamin d3 with therapeutic effect on enhancing bone mineral density in vivo.EBI
ACS Med Chem Lett 4: 671-4 (2013)
Teikyo University
Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics.EBI
ACS Med Chem Lett 4: 627-31 (2013)
Osi Pharmaceuticals
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors.EBI
ACS Med Chem Lett 4: 622-6 (2013)
Universit£
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.EBI
ACS Med Chem Lett 4: 612-5 (2013)
University of Debrecen
4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.EBI
ACS Med Chem Lett 4: 606-11 (2013)
Universit£
Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of ?-Amyloid Plaques.EBI
ACS Med Chem Lett 4: 596-600 (2013)
Kyoto University
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections.EBI
ACS Med Chem Lett 4: 585-9 (2013)
Biofocus
?-Secretase Inhibitors for the Treatment of Alzheimer's Disease and Down's Syndrome.EBI
ACS Med Chem Lett 4: 578-9 (2013)
Therachem Research Medilab (India)
ERK2 Inhibitors May Provide Treatment for Cancer.EBI
ACS Med Chem Lett 4: 576-7 (2013)
Therachem Research Medilab (India)
FPRL-1 Receptor Modulators May Provide Treatment for Inflammation.EBI
ACS Med Chem Lett 4: 574-5 (2013)
Therachem Research Medilab (India)
Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.EBI
ACS Med Chem Lett 4: 565-9 (2013)
University of Florence
Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.EBI
ACS Med Chem Lett 4: 560-4 (2013)
Eli Lilly
Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.EBI
ACS Med Chem Lett 4: 551-5 (2013)
Amgen
Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4.EBI
ACS Med Chem Lett 4: 532-7 (2013)
University of Alberta
Development of Unsymmetrical Dyads As Potent Noncarbohydrate-Based Inhibitors against Human ?-N-Acetyl-d-hexosaminidase.EBI
ACS Med Chem Lett 4: 527-31 (2013)
East China University of Science and Technology
Metabolically Stable tert-Butyl Replacement.EBI
ACS Med Chem Lett 4: 514-6 (2013)
Novartis Institutes For Biomedical Research
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.EBI
ACS Med Chem Lett 4: 509-13 (2013)
Merck Research Laboratories
Identification of New Nonsteroidal ROR? Ligands; Related Structure-Activity Relationships and Docking Studies.EBI
ACS Med Chem Lett 4: 504-8 (2013)
Genfit
Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease.EBI
ACS Med Chem Lett 4: 502-3 (2013)
Dart Neuroscience
Negative allosteric modulators of metabotropic glutamate receptor subtype.EBI
ACS Med Chem Lett 4: 500-1 (2013)
Dart Neuroscience
Imidazopyrazine Derivatives As Inhibitors of mTOR.EBI
ACS Med Chem Lett 4: 498-9 (2013)
Dart Neuroscience
Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold.EBI
ACS Med Chem Lett 4: 491-6 (2013)
University of Antwerp (Ua)
Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.EBI
ACS Med Chem Lett 4: 475-80 (2013)
Chinese Academy of Sciences
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.EBI
ACS Med Chem Lett 4: 466-9 (2013)
Roche Research Center
Novel thiazolobenzodiazepines as inhibitors of histamine h3 receptor.EBI
ACS Med Chem Lett 4: 435-435 (2013)
Dart Neuroscience
Dihydrooxazines As Inhibitors of BACE-1 or BACE-2.EBI
ACS Med Chem Lett 4: 433-4 (2013)
Dart Neuroscience
PAK1: A Therapeutic Target for Cancer Treatment.EBI
ACS Med Chem Lett 4: 431-2 (2013)
Therachem Research Medilab (India)
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.EBI
ACS Med Chem Lett 4: 419-22 (2013)
Janssen Research and Development
Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes.EBI
ACS Med Chem Lett 4: 414-8 (2013)
Hoffmann-La Roche
Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.EBI
ACS Med Chem Lett 4: 408-13 (2013)
Soochow University
Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of?1 GABAC Receptors.EBI
ACS Med Chem Lett 4: 402-7 (2013)
The University of Sydney
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.EBI
ACS Med Chem Lett 4: 393-6 (2013)
University of Regensburg
Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors.EBI
ACS Med Chem Lett 4: 379-80 (2013)
Temple University
Selective Cyp11B1 Inhibitors for the Treatment of Cortisol Dependent Diseases.EBI
ACS Med Chem Lett 4: 377-8 (2013)
Temple University
Aldosterone synthase inhibitors.EBI
ACS Med Chem Lett 4: 375-6 (2013)
Temple University
Targeting CCR2 Receptor To Treat Inflammation Diseases and Disorders.EBI
ACS Med Chem Lett 4: 371-2 (2013)
Therachem Research Medilab (India)
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors.EBI
ACS Med Chem Lett 4: 358-62 (2013)
Glaxosmithkline
Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.EBI
ACS Med Chem Lett 4: 353-7 (2013)
Entremed
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.EBI
ACS Med Chem Lett 4: 333-7 (2013)
Genomics Institute of The Novartis Research Foundation
Inhibition of mTOR Kinase and Cancer Treatment.EBI
ACS Med Chem Lett 4: 321-2 (2013)
Therachem Research Medilab (India)
Positive allosteric modulators of nicotinic acetylcholine receptor.EBI
ACS Med Chem Lett 4: 319-20 (2013)
Dart Neuroscience
High-Throughput Selectivity Assays for Small-Molecule Inhibitors of ?-Catenin/T-Cell Factor Protein-Protein Interactions.EBI
ACS Med Chem Lett 4: 306-11 (2013)
University of Utah
Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors.EBI
ACS Med Chem Lett 4: 297-301 (2013)
Gakushuin University
Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.EBI
ACS Med Chem Lett 4: 293-6 (2013)
Glaxosmithkline
Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors.EBI
ACS Med Chem Lett 4: 259-63 (2013)
Hoffmann-La Roche
Interrogation of the Active Sites of Protein Arginine Deiminases (PAD1, -2, and -4) Using Designer Probes.EBI
ACS Med Chem Lett 4: 249-53 (2013)
University Health Network
Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.EBI
ACS Med Chem Lett 4: 244-8 (2013)
Dainippon Sumitomo Pharma
[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase ? Inhibitors.EBI
ACS Med Chem Lett 4: 230-4 (2013)
Glaxosmithkline
Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.EBI
ACS Med Chem Lett 4: 211-5 (2013)
Abbott Laboratories
The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.EBI
ACS Med Chem Lett 4: 186-90 (2013)
Novartis Institutes For Biomedical Research
Irreversible inhibitors of cysteine proteases.EBI
ACS Med Chem Lett 4: 163-4 (2013)
Dart Neuroscience
PDE10 Inhibitors as Potential Treatment for Schizophrenia.EBI
ACS Med Chem Lett 4: 161-2 (2013)
Therachem Research Medilab (India)
TRPV4 Antagonists: Potential Treatment for Congestive Heart Failure, Bladder Dysfunctions, and Pain.EBI
ACS Med Chem Lett 4: 159-60 (2013)
Therachem Research Medilab (India)
Aldosterone synthase inhibitors: targeting chronic kidney disease and diabetic nephropathy.EBI
ACS Med Chem Lett 4: 157-8 (2013)
Therachem Research Medilab (India)
Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand.EBI
ACS Med Chem Lett 4: 269-73 (2013)
Goethe University
Synthesis and antimycobacterial activity of 2,1'-dihydropyridomycins.EBI
ACS Med Chem Lett 4: 264-8 (2013)
Swiss Federal Institute of Technology (Eth) Zurich
Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.EBI
ACS Med Chem Lett 4: 201-5 (2013)
Takeda Pharmaceutical
Synthesis and antimalarial activity of 3,3-spiroanellated 5,6-disubstituted 1,2,4-trioxanes.EBI
ACS Med Chem Lett 4: 165-9 (2013)
Division of Medicinal & Process Chemistry, Division of Parasitology, Division of Pharmacokinetics and Metabolism, and Sophisticated Analytical Instrument Facility, Central Drug Research Institute
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.EBI
ACS Med Chem Lett 4: 1238-43 (2013)
Glaxosmithkline
Design and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications.EBI
ACS Med Chem Lett 4: 1228-32 (2013)
University of Copenhagen
Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors.EBI
ACS Med Chem Lett 4: 1218-23 (2013)
Amgen
Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase.EBI
ACS Med Chem Lett 4: 1208-12 (2013)
Astex Pharmaceuticals
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.EBI
ACS Med Chem Lett 4: 1203-7 (2013)
Novartis Institutes For Biomedical Research
Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds.EBI
ACS Med Chem Lett 4: 1198-202 (2013)
University of Cape Town
Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.EBI
ACS Med Chem Lett 4: 1193-7 (2013)
Novartis Institutes For Biomedical Research
Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase.EBI
ACS Med Chem Lett 4: 1183-8 (2013)
Yale University
Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.EBI
ACS Med Chem Lett 4: 1178-82 (2013)
University of Siena
Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases.EBI
ACS Med Chem Lett 4: 1173-7 (2013)
University of Bath
Exploring the chemical space of multitarget ligands using aligned self-organizing maps.EBI
ACS Med Chem Lett 4: 1169-72 (2013)
Goethe University
Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion.EBI
ACS Med Chem Lett 4: 1163-8 (2013)
Astrazeneca
Probing the Binding Site of Bile Acids in TGR5.EBI
ACS Med Chem Lett 4: 1158-62 (2013)
Universit£
Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors.EBI
ACS Med Chem Lett 4: 1152-7 (2013)
Aurigene Discovery Technologies
Diphenylpropane Derivatives as Agonist of PPAR Nuclear Receptors.EBI
ACS Med Chem Lett 4: 1135-6 (2013)
Dart Neuroscience
Inhibition of CK2: An Attractive Therapeutic Target for Cancer Treatment.EBI
ACS Med Chem Lett 4: 1131-2 (2013)
Therachem Research Medilab (India)
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma.EBI
ACS Med Chem Lett 4: 1102-7 (2013)
University of Toronto At Mississauga
Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility.EBI
ACS Med Chem Lett 4: 1091-6 (2013)
New York Structural Biology Center
Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.EBI
ACS Med Chem Lett 4: 1079-84 (2013)
Pfizer
Potent oxazolidinone antibacterials with heteroaromatic C-ring substructure.EBI
ACS Med Chem Lett 4: 1074-8 (2013)
Research Foundation Itsuu Laboratory
Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide.EBI
ACS Med Chem Lett 4: 1064-8 (2013)
Merck Research Laboratories
Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.EBI
ACS Med Chem Lett 4: 1059-63 (2013)
Chugai Pharmaceutical
Discovery of Octahydroindenes as PAR1 Antagonists.EBI
ACS Med Chem Lett 4: 1054-8 (2013)
Korea Research Institute of Technology
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.EBI
ACS Med Chem Lett 4: 1037-41 (2013)
Merck Serono
Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.EBI
ACS Med Chem Lett 4: 1031-6 (2013)
University of Santiago De Compostela
N-[4-(1H-Pyrazolo[3,4-B]pyrazin-6yl)-phenyl]-sulonamides and Their Use As Pharmaceuticals.EBI
ACS Med Chem Lett 4: 1022-4 (2013)
Temple University
Endothelial lipase inhibitors for the treatment of atherosclerosis and cardiovascular disorders.EBI
ACS Med Chem Lett 4: 1016-7 (2013)
Therachem Research Medilab (India)
Sphingosine-1-phosphate (S1P) Receptor Modulators Provide Potential for Diverse Treatments.EBI
ACS Med Chem Lett 4: 1014-5 (2013)
Therachem Research Medilab (India)
Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.EBI
ACS Med Chem Lett 4: 974-8 (2013)
Zhejiang University
Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.EBI
ACS Med Chem Lett 4: 964-8 (2013)
Glaxosmithkline
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.EBI
ACS Med Chem Lett 4: 948-52 (2013)
Glaxosmithkline
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis.EBI
ACS Med Chem Lett 4: 942-7 (2013)
Praecis Pharmaceuticals
Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.EBI
ACS Med Chem Lett 4: 937-41 (2013)
Tokyo Medical and Dental University
Discovery of DF-461, a Potent Squalene Synthase Inhibitor.EBI
ACS Med Chem Lett 4: 932-6 (2013)
Daiichi Sankyo
Anabaseine analogues as modulators of nicotinic acetylcholine receptor.EBI
ACS Med Chem Lett 4: 902-3 (2013)
Dart Neuroscience
Fighting Obesity and Metabolic Disorders with MGAT-2 Inhibitors.EBI
ACS Med Chem Lett 4: 898-9 (2013)
Therachem Research Medilab (India)
Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-?/SPD304 Study.EBI
ACS Med Chem Lett 4: 137-41 (2013)
The Centre For Research and Technology of Thessaly (Ce.Re.Te.Th.)
Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.EBI
ACS Med Chem Lett 4: 132-6 (2013)
Chinese Academy of Sciences
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.EBI
ACS Med Chem Lett 4: 118-23 (2013)
Pfizer
Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.EBI
ACS Med Chem Lett 4: 113-7 (2013)
3-V Biosciences
Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.EBI
ACS Med Chem Lett 4: 103-7 (2013)
Genentech
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.EBI
ACS Med Chem Lett 4: 91-7 (2013)
Pfizer
Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.EBI
ACS Med Chem Lett 4: 85-90 (2013)
Genentech
Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.EBI
ACS Med Chem Lett 4: 63-8 (2013)
Pfizer
Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.EBI
ACS Med Chem Lett 4: 46-51 (2013)
Astrazeneca
Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55.EBI
ACS Med Chem Lett 4: 41-5 (2013)
University of Bonn
Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.EBI
ACS Med Chem Lett 4: 37-40 (2013)
Pfizer
Spleen Tyrosine Kinase Inhibitors (SYK) as Potential Treatment for Autoimmune and Inflammatory Disorders: Patent Highlight.EBI
ACS Med Chem Lett 4: 18-9 (2013)
Therachem Research Medilab (India)
Treatment of Obesity and Related Disorders with Acetyl-CoA Carboxylase Inhibitors.EBI
ACS Med Chem Lett 4: 16-7 (2013)
Therachem Research Medilab (India)
Modulators of the GPR119 Receptor for the Treatment of Metabolic Syndrome.EBI
ACS Med Chem Lett 4: 8-9 (2013)
Dart Neuroscience
Metabolites of the pyrimidine amine preladenant as adenosine a2a receptor antagonists.EBI
ACS Med Chem Lett 4: 5-6 (2013)
Dart Neuroscience
Fluorescent Human EP3 Receptor Antagonists.EBI
ACS Med Chem Lett 3: 774-779 (2012)
TBA
Symmetric kv1.5 blockers discovered by focused screening.EBI
ACS Med Chem Lett 3: 769-773 (2012)
TBA
Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor.EBI
ACS Med Chem Lett 3: 764-768 (2012)
TBA
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.EBI
ACS Med Chem Lett 3: 754-758 (2012)
TBA
Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.EBI
ACS Med Chem Lett 3: 749-753 (2012)
TBA
Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease.EBI
ACS Med Chem Lett 3: 731-735 (2012)
TBA
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.EBI
ACS Med Chem Lett 3: 726-730 (2012)
TBA
Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.EBI
ACS Med Chem Lett 3: 705-709 (2012)
TBA
Prostaglandin e2 synthase-1 inhibitors as potential treatment for osteoarthritis: patent highlight.EBI
ACS Med Chem Lett 3: 703-704 (2012)
TBA
Inhibitors of LRRK2 as Treatment for Parkinson's Disease: Patent Highlight.EBI
ACS Med Chem Lett 3: 701-702 (2012)
TBA
Cyclopropyl-spiro-piperidines Useful as Sodium Channel Blockers: Patent Highlight.EBI
ACS Med Chem Lett 3: 697-698 (2012)
TBA
Substituted pyridines as sodium channel blockers: patent highlight.EBI
ACS Med Chem Lett 3: 695-696 (2012)
TBA
Bromodomains: are readers right for epigenetic therapy?EBI
ACS Med Chem Lett 3: 691-694 (2012)
TBA
Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.EBI
ACS Med Chem Lett 3: 678-682 (2012)
TBA
Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12.EBI
ACS Med Chem Lett 3: 653-657 (2012)
TBA
Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects.EBI
ACS Med Chem Lett 3: 637-639 (2012)
TBA
Substituted benzimidazole and imidazopyridine compounds useful as cyp17 modulators: patent highlight.EBI
ACS Med Chem Lett 3: 614-615 (2012)
TBA
Fatty Acid synthase inhibitors as possible treatment for cancer: patent highlight.EBI
ACS Med Chem Lett 3: 612-613 (2012)
TBA
Potassium channel modulators as possible treatment for pain: patent highlight.EBI
ACS Med Chem Lett 3: 608-9 (2012)
Therachem Research Medilab (India)
Lipophilic Isosteres of a ?-? Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction.EBI
ACS Med Chem Lett 3: 579-83 (2012)
Novartis Institutes For Biomedical Research
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.EBI
ACS Med Chem Lett 3: 560-564 (2012)
TBA
Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues.EBI
ACS Med Chem Lett 3: 550-554 (2012)
TBA
Identification of new snake venom metalloproteinase inhibitors using compound screening and rational Peptide design.EBI
ACS Med Chem Lett 3: 540-543 (2012)
TBA
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.EBI
ACS Med Chem Lett 3: 535-539 (2012)
TBA
Design and synthesis of potent, selective inhibitors of matriptase.EBI
ACS Med Chem Lett 3: 530-534 (2012)
TBA
Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors.EBI
ACS Med Chem Lett 3: 524-529 (2012)
TBA
Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase.EBI
ACS Med Chem Lett 3: 509-514 (2012)
TBA
Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.EBI
ACS Med Chem Lett 3: 505-508 (2012)
TBA
The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.EBI
ACS Med Chem Lett 3: 484-489 (2012)
TBA
Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.EBI
ACS Med Chem Lett 3: 450-453 (2012)
TBA
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.EBI
ACS Med Chem Lett 3: 445-449 (2012)
TBA
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.EBI
ACS Med Chem Lett 3: 427-432 (2012)
TBA
▀-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine.EBI
ACS Med Chem Lett 3: 422-426 (2012)
TBA
Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973).EBI
ACS Med Chem Lett 3: 416-421 (2012)
TBA
Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides.EBI
ACS Med Chem Lett 3: 411-415 (2012)
TBA
Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents.EBI
ACS Med Chem Lett 3: 397-401 (2012)
TBA
Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.EBI
ACS Med Chem Lett 3: 387-391 (2012)
TBA
Targeted kinase selectivity from kinase profiling data.EBI
ACS Med Chem Lett 3: 383-386 (2012)
TBA
A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold.EBI
ACS Med Chem Lett 3: 373-377 (2012)
TBA
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.EBI
ACS Med Chem Lett 3: 367-372 (2012)
TBA
The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity.EBI
ACS Med Chem Lett 3: 352-356 (2012)
TBA
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.EBI
ACS Med Chem Lett 3: 342-346 (2012)
TBA
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.EBI
ACS Med Chem Lett 3: 337-341 (2012)
TBA
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.EBI
ACS Med Chem Lett 3: 332-6 (2012)
Merck Research Laboratories
Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.EBI
ACS Med Chem Lett 3: 289-293 (2012)
TBA
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.EBI
ACS Med Chem Lett 3: 278-283 (2012)
TBA
Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators.EBI
ACS Med Chem Lett 3: 273-277 (2012)
TBA
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.EBI
ACS Med Chem Lett 3: 252-256 (2012)
TBA
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with Á-Opioid Agonist Activity.EBI
ACS Med Chem Lett 3: 227-231 (2012)
TBA
Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists.EBI
ACS Med Chem Lett 3: 222-226 (2012)
TBA
Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication.EBI
ACS Med Chem Lett 3: 216-221 (2012)
TBA
Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.EBI
ACS Med Chem Lett 3: 203-206 (2012)
TBA
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.EBI
ACS Med Chem Lett 3: 187-192 (2012)
TBA
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?EBI
ACS Med Chem Lett 3: 182-186 (2012)
TBA
Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.EBI
ACS Med Chem Lett 3: 198-202 (2012)
TBA
BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor?EBI
ACS Med Chem Lett 3: 193-197 (2012)
TBA
Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists.EBI
ACS Med Chem Lett 3: 165-169 (2012)
TBA
Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group.EBI
ACS Med Chem Lett 3: 159-164 (2012)
TBA
Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering.EBI
ACS Med Chem Lett 3: 155-158 (2012)
TBA
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.EBI
ACS Med Chem Lett 3: 140-145 (2012)
TBA
Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode.EBI
ACS Med Chem Lett 3: 123-128 (2012)
TBA
Application of MM-GB/SA and WaterMap to SRC Kinase Inhibitor Potency Prediction.EBI
ACS Med Chem Lett 3: 94-99 (2012)
TBA
Synthesis and biological evaluation of cyclic sulfamide derivatives as 11▀-hydroxysteroid dehydrogenase 1 inhibitors.EBI
ACS Med Chem Lett 3: 88-93 (2012)
TBA
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor.EBI
ACS Med Chem Lett 3: 135-139 (2012)
TBA
Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.EBI
ACS Med Chem Lett 3: 106-111 (2012)
TBA
Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.EBI
ACS Med Chem Lett 3: 100-105 (2012)
TBA
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.EBI
ACS Med Chem Lett 3: 1091-1096 (2012)
TBA
Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.EBI
ACS Med Chem Lett 3: 1070-1074 (2012)
TBA
Structure-Based Design of Potent and Selective CK1┐ Inhibitors.EBI
ACS Med Chem Lett 3: 1059-1064 (2012)
TBA
Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.EBI
ACS Med Chem Lett 3: 1050-1053 (2012)
TBA
A new approach to explore the binding space of polysaccharide-based ligands: selectin antagonists.EBI
ACS Med Chem Lett 3: 1045-1049 (2012)
TBA
Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate.EBI
ACS Med Chem Lett 3: 1039-1044 (2012)
TBA
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease.EBI
ACS Med Chem Lett 3: 1024-1028 (2012)
TBA
Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases.EBI
ACS Med Chem Lett 3: 997-1002 (2012)
TBA
Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.EBI
ACS Med Chem Lett 3: 969-974 (2012)
TBA
Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.EBI
ACS Med Chem Lett 3: 959-964 (2012)
TBA
GPR119 Modulators for the Treatment of Diabetes, Obesity, and Related Diseases: Patent Highlight.EBI
ACS Med Chem Lett 3: 955-958 (2012)
TBA
Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.EBI
ACS Med Chem Lett 3: 936-941 (2012)
TBA
Synthesis and SAR Studies of Fused Oxadiazines as ?-Secretase Modulators for Treatment of Alzheimer's Disease.EBI
ACS Med Chem Lett 3: 931-5 (2012)
Merck Research Laboratory
Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.EBI
ACS Med Chem Lett 3: 920-924 (2012)
TBA
Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.EBI
ACS Med Chem Lett 3: 914-919 (2012)
TBA
Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside.EBI
ACS Med Chem Lett 3: 908-13 (2012)
Satori Pharmaceuticals
Discovery of SCH 900229, a Potent Presenilin 1 Selective ┐-Secretase Inhibitor for the Treatment of Alzheimer's Disease.EBI
ACS Med Chem Lett 3: 892-896 (2012)
TBA
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of ▀-Secretase.EBI
ACS Med Chem Lett 3: 886-891 (2012)
TBA
Benzenesulfonyl and Benzenesulfonamide as Modulators of the 5-HT6 Receptor: Patent Highlight.EBI
ACS Med Chem Lett 3: 881-2 (2012)
Dart Neuroscience
Novel and selective inhibitors of histone deacetylase: patent highlight.EBI
ACS Med Chem Lett 3: 879-80 (2012)
Dart Neuroscience
Compounds and Their Use as BACE Inhibitors: Patent Highlight.EBI
ACS Med Chem Lett 3: 875-876 (2012)
TBA
5-Amino-oxazepine and 5-Amino-thiazepine Compounds as ▀-Secretase Antagonists and Methods of Use: Patent Highlight.EBI
ACS Med Chem Lett 3: 873-874 (2012)
TBA
BACE-Inhibitors: Potential Treatment of Alzheimer Disease, Dementia, and Related Neurodegenerative Diseases. C. Spiro-Heterocyclic Derivatives: Patent Highlight.EBI
ACS Med Chem Lett 3: 871-872 (2012)
TBA
BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (B): 3-Amino-4-fluoro-1H-isoindol Derivatives: Patent Highlight.EBI
ACS Med Chem Lett 3: 869-870 (2012)
TBA
BACE Inhibitors: Potential Treatment of Alzheimer's Disease, Dementia, and Related Neurodegenerative Disorders (A): 5,6-Dihydroimidazo[1,2-a]pyrazin-8-yl-amine Derivatives: Patent Highlight.EBI
ACS Med Chem Lett 3: 867-868 (2012)
TBA
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.EBI
ACS Med Chem Lett 3: 850-855 (2012)
TBA
Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.EBI
ACS Med Chem Lett 3: 834-838 (2012)
TBA
Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.EBI
ACS Med Chem Lett 3: 823-827 (2012)
TBA
Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11▀-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.EBI
ACS Med Chem Lett 3: 793-798 (2012)
TBA
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.EBI
ACS Med Chem Lett 3: 789-792 (2012)
TBA
Novel compounds for the treatment of neurodegenerative diseases: patent highlight.EBI
ACS Med Chem Lett 3: 788-788 (2012)
TBA
Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors: Patent Highlight.EBI
ACS Med Chem Lett 3: 783-784 (2012)
TBA
Factor D Inhibitors for the Treatment of AMD: Patent Highlight.EBI
ACS Med Chem Lett 3: 781-782 (2012)
TBA
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.EBI
ACS Med Chem Lett 3: 74-78 (2012)
TBA
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.EBI
ACS Med Chem Lett 3: 63-68 (2012)
TBA
(18)F-labeled phenyldiazenyl benzothiazole for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains.EBI
ACS Med Chem Lett 3: 58-62 (2012)
TBA
Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.EBI
ACS Med Chem Lett 3: 20-24 (2012)
TBA
Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo.EBI
ACS Med Chem Lett 3: 10-14 (2012)
TBA
Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.EBI
ACS Med Chem Lett 2: 708-713 (2011)
TBA
A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of ?-Amyloid Plaques.EBI
ACS Med Chem Lett 2: 673-7 (2011)
Technische Universit£T M£Nchen
Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.EBI
ACS Med Chem Lett 2: 662-666 (2011)
TBA
Synthesis and Cardiac Imaging of (18)F-Ligands Selective for ▀1-Adrenoreceptors.EBI
ACS Med Chem Lett 2: 650-655 (2011)
TBA
Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.EBI
ACS Med Chem Lett 2: 644-649 (2011)
TBA
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.EBI
ACS Med Chem Lett 2: 632-637 (2011)
TBA
The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease.EBI
ACS Med Chem Lett 2: 614-619 (2011)
TBA
Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity.EBI
ACS Med Chem Lett 2: 583-586 (2011)
TBA
Bivalent Ligands for the Serotonin 5-HT3 Receptor.EBI
ACS Med Chem Lett 2: 571-576 (2011)
TBA
Optimization of the First Selective Steroid-11▀-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.EBI
ACS Med Chem Lett 2: 559-564 (2011)
TBA
Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site.EBI
ACS Med Chem Lett 2: 538-543 (2011)
TBA
Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.EBI
ACS Med Chem Lett 2: 532-7 (2011)
Lomonosov Moscow State University
Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.EBI
ACS Med Chem Lett 2: 519-522 (2011)
TBA
Benzodiazepinone Derivatives as CRTH2 Antagonists.EBI
ACS Med Chem Lett 2: 515-518 (2011)
TBA
N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.EBI
ACS Med Chem Lett 2: 509-514 (2011)
TBA
Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as ?-Amyloid PET Ligands and Identification of MK-3328.EBI
ACS Med Chem Lett 2: 498-502 (2011)
Merck Research Laboratories
Ranking high affinity ligands of low solubility by NMR spectroscopy.EBI
ACS Med Chem Lett 2: 485-487 (2011)
TBA
N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.EBI
ACS Med Chem Lett 2: 481-484 (2011)
TBA
Potent CXCR4 antagonists containing amidine type Peptide bond isosteres.EBI
ACS Med Chem Lett 2: 477-480 (2011)
TBA
Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors.EBI
ACS Med Chem Lett 2: 461-5 (2011)
University of Southampton
The impact of ionization States of matrix metalloproteinase inhibitors on docking-based inhibitor design.EBI
ACS Med Chem Lett 2: 455-460 (2011)
TBA
Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist.EBI
ACS Med Chem Lett 2: 450-454 (2011)
TBA
Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases.EBI
ACS Med Chem Lett 2: 428-432 (2011)
TBA
Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.EBI
ACS Med Chem Lett 2: 424-427 (2011)
TBA
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.EBI
ACS Med Chem Lett 2: 407-412 (2011)
TBA
Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases.EBI
ACS Med Chem Lett 2: 402-406 (2011)
TBA
Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.EBI
ACS Med Chem Lett 2: 368-372 (2011)
TBA
Indomethacin Analogues that Enhance Doxorubicin Cytotoxicity in Multidrug Resistant Cells without Cox Inhibitory Activity.EBI
ACS Med Chem Lett 2: 353-357 (2011)
TBA
Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.EBI
ACS Med Chem Lett 2: 342-7 (2011)
Array Biopharma
Discovery of AMG 853, a CRTH2 and DP Dual Antagonist.EBI
ACS Med Chem Lett 2: 326-330 (2011)
TBA
Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein InhibitorsEBI
ACS Med Chem Lett 2: 219-223 (2011)
TBA
Hybrid Dual Aromatase-Steroid Sulfatase Inhibitors with Exquisite Picomolar Inhibitory ActivityEBI
ACS Med Chem Lett 2: 243-247 (2011)
TBA
Discovery of a Potent and Short−Acting Oral Calcilytic with a Pulsatile Secretion of Parathyroid HormoneEBI
ACS Med Chem Lett 2: 238-242 (2011)
TBA
Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor AntagonistEBI
ACS Med Chem Lett 2: 213-218 (2011)
TBA
Synthesis and SAR of Thiazolylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 InhibitorsEBI
ACS Med Chem Lett 2: 182-187 (2011)
TBA
Sulfonate-Containing Thiiranes as Selective Gelatinase InhibitorsEBI
ACS Med Chem Lett 2: 177-181 (2011)
TBA
Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of DyslipidemiaEBI
ACS Med Chem Lett 2: 171-176 (2011)
TBA
Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine FibroidsEBI
ACS Med Chem Lett 2: 148-153 (2011)
TBA
Discovery of novel cyanamide-based inhibitors of cathepsin C.EBI
ACS Med Chem Lett 2: 142-147 (2011)
TBA
TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT.EBI
ACS Med Chem Lett 2: 136-141 (2011)
TBA
Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140EBI
ACS Med Chem Lett 2: 124-129 (2011)
TBA
Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated IminosugarsEBI
ACS Med Chem Lett 2: 119-123 (2011)
TBA
Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5EBI
ACS Med Chem Lett 2: 107-112 (2011)
TBA
Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)EBI
ACS Med Chem Lett 2: 102-106 (2011)
TBA
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MSEBI
ACS Med Chem Lett 2: 97-101 (2011)
TBA
Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.EBI
ACS Med Chem Lett 2: 938-942 (2011)
TBA
Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.EBI
ACS Med Chem Lett 2: 933-937 (2011)
TBA
Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats.EBI
ACS Med Chem Lett 2: 919-923 (2011)
TBA
Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist.EBI
ACS Med Chem Lett 2: 913-918 (2011)
TBA
Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists.EBI
ACS Med Chem Lett 2: 890-895 (2011)
TBA
Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum.EBI
ACS Med Chem Lett 2: 866-869 (2011)
TBA
Homology Model and Docking-Based Virtual Screening for Ligands of the s1 Receptor.EBI
ACS Med Chem Lett 2: 834-839 (2011)
TBA
Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.EBI
ACS Med Chem Lett 2: 824-827 (2011)
TBA
Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.EBI
ACS Med Chem Lett 2: 809-813 (2011)
TBA
Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases.EBI
ACS Med Chem Lett 2: 804-808 (2011)
TBA
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable ┐-Secretase Modulator.EBI
ACS Med Chem Lett 2: 786-791 (2011)
TBA
Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer.EBI
ACS Med Chem Lett 2: 774-779 (2011)
TBA
The Discovery of VX-745: A Novel and Selective p38a Kinase Inhibitor.EBI
ACS Med Chem Lett 2: 758-763 (2011)
TBA
4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.EBI
ACS Med Chem Lett 2: 752-757 (2011)
TBA
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.EBI
ACS Med Chem Lett 2: 747-751 (2011)
TBA
3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors.EBI
ACS Med Chem Lett 2: 720-723 (2011)
TBA
Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor AntagonistEBI
ACS Med Chem Lett 2: 85-89 (2011)
TBA
Benzimidazoles as Potent and Orally Active mGlu5 Receptor Antagonists with an Improved PK ProfileEBI
ACS Med Chem Lett 2: 58-62 (2011)
TBA
Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands.EBI
ACS Med Chem Lett 2: 53-57 (2011)
TBA
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of ObesityEBI
ACS Med Chem Lett 2: 43-47 (2011)
TBA
Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase InhibitorsEBI
ACS Med Chem Lett 2: 34-38 (2011)
TBA
Kinase Inhibition by Deoxy Analogues of the Resorcylic Lactone L-783277EBI
ACS Med Chem Lett 2: 22-27 (2011)
TBA
Novel Cyclic Phosphinic Acids as GABAC ρ Receptor Antagonists: Design, Synthesis, and PharmacologyEBI
ACS Med Chem Lett 2: 11-16 (2011)
TBA
First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent DiseasesEBI
ACS Med Chem Lett 2: 2-6 (2011)
TBA
Facile synthesis of a fluorescent cyclosporin a analogue to study cyclophilin 40 and cyclophilin 18 ligands.EBI
ACS Med Chem Lett 1: 536-539 (2010)
TBA
Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors.EBI
ACS Med Chem Lett 1: 530-535 (2010)
TBA
Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.EBI
ACS Med Chem Lett 1: 526-529 (2010)
TBA
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers.EBI
ACS Med Chem Lett 1: 521-525 (2010)
TBA
Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.EBI
ACS Med Chem Lett 1: 510-515 (2010)
TBA
Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.EBI
ACS Med Chem Lett 1: 504-509 (2010)
TBA
Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity.EBI
ACS Med Chem Lett 1: 493-498 (2010)
TBA
Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.EBI
ACS Med Chem Lett 1: 488-492 (2010)
TBA
Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity.EBI
ACS Med Chem Lett 1: 483-487 (2010)
TBA
Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.EBI
ACS Med Chem Lett 1: 472-477 (2010)
TBA
Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.EBI
ACS Med Chem Lett 1: 454-459 (2010)
TBA
Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.EBI
ACS Med Chem Lett 1: 439-442 (2010)
TBA
Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB.EBI
ACS Med Chem Lett 1: 422-426 (2010)
TBA
From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.EBI
ACS Med Chem Lett 1: 416-421 (2010)
TBA
Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.EBI
ACS Med Chem Lett 1: 411-5 (2010)
Menarini Ricerche
Identification of a New Series of STAT3 Inhibitors by Virtual Screening.EBI
ACS Med Chem Lett 1: 371-375 (2010)
TBA
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.EBI
ACS Med Chem Lett 1: 350-354 (2010)
TBA
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.EBI
ACS Med Chem Lett 1: 345-349 (2010)
TBA
Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands.EBI
ACS Med Chem Lett 1: 340-344 (2010)
TBA
Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists.EBI
ACS Med Chem Lett 1: 316-320 (2010)
TBA
Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist.EBI
ACS Med Chem Lett 1: 290-294 (2010)
TBA
Synthesis and Biochemical Testing of 3-(Carboxyphenylethyl)imidazo[2,1-f][1,2,4]triazines as Inhibitors of AMP Deaminase.EBI
ACS Med Chem Lett 1: 286-289 (2010)
TBA
Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators.EBI
ACS Med Chem Lett 1: 263-267 (2010)
TBA
Synthesis and Biological Evaluation of Muraymycin Analogues Active against Anti-Drug-Resistant Bacteria.EBI
ACS Med Chem Lett 1: 258-262 (2010)
TBA
Development of Fluorescent Ligands for the Human 5-HT1A Receptor.EBI
ACS Med Chem Lett 1: 249-253 (2010)
TBA
Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.EBI
ACS Med Chem Lett 1: 244-248 (2010)
TBA
Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.EBI
J Med Chem 57: 5179-89 (2014)
Saarland University
Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation.EBI
Bioorg Med Chem Lett 24: 3142-5 (2014)
Sungkyunkwan University
Development of synthetic lethality anticancer therapeutics.EBI
J Med Chem 57: 7859-73 (2014)
The University of Texas M.D. Anderson Cancer Center
Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin.BDB
J Biol Chem 289: 19704-13 (2014)
Yale University
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR).EBI
Bioorg Med Chem 22: 3713-9 (2014)
University of Strasburg
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.EBI
Bioorg Med Chem 22: 3753-72 (2014)
Duquesne University
Thiazolidine-2,4-diones derivatives as PPAR-┐ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-┐ gene expression.EBI
Bioorg Med Chem Lett 24: 3034-42 (2014)
Jamia Hamdard (Hamdard University)
Identification of 1, 4-Dihydrothieno [3', 2':5, 6]thiopyrano[4, 3-c] pyrazole derivatives as human 5-Lipo-oxygenase inhibitors.BDB
Chem Biol Drug Des 84: 642-7 (2014)
Peking University
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEd prenyl binding site.EBI
J Med Chem 57: 5435-48 (2014)
Max Planck Institute of Molecular Physiology
Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.EBI
J Med Chem 57: 5129-40 (2014)
Genomics Institute of The Novartis Research Foundation
Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52.EBI
J Med Chem 57: 5226-37 (2014)
Takeda Pharmaceutical
Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.EBI
ACS Med Chem Lett 5: 29-33 (2014)
Medical University of South Carolina
Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: design, synthesis and evaluation as antibacterial agent.EBI
Bioorg Med Chem 22: 3620-8 (2014)
Jishou University
Design, synthesis and biological evaluation of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 4-oxo-3,4-dihydrophthalazine-1-carboxamide moieties as c-Met kinase inhibitors.EBI
Bioorg Med Chem 22: 3642-53 (2014)
Shenyang Pharmaceutical University
Towards the next generation of dual Bcl-2/Bcl-xL inhibitors.EBI
Bioorg Med Chem Lett 24: 3026-33 (2014)
Astrazeneca
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).EBI
Bioorg Med Chem Lett 24: 3100-3 (2014)
Glaxosmithkline
Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.EBI
Bioorg Med Chem Lett 24: 3018-22 (2014)
Bristol-Myers Squibb Research and Development
Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists.EBI
Bioorg Med Chem Lett 24: 3204-6 (2014)
Astrazeneca
Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole.EBI
Bioorg Med Chem Lett 24: 3050-6 (2014)
Chinese Academy of Sciences
Novel synthesis of dihydropyrimidines for a-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking.BDB
Bioorg Chem 54: 96-104 (2014)
Comsats Institute of Information Technology
Inhibition of Enterococcus faecalis biofilm formation by highly active lactones and lactams analogues of rubrolides.EBI
Eur J Med Chem 82: 127-38 (2014)
Federal University of Vi£Osa
Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties.EBI
Eur J Med Chem 82: 96-105 (2014)
University of Namur (Unamur)
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.EBI
Bioorg Med Chem 22: 3684-95 (2014)
King Saud University
Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT6 and dopamine D2 receptor ligands.EBI
J Med Chem 57: 5823-8 (2014)
University of Copenhagen
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors.EBI
J Med Chem 57: 5258-69 (2014)
Pfizer
Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.EBI
Bioorg Med Chem Lett 24: 3108-12 (2014)
Csiro Manufacturing Flagship (Biomedical)
Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors.EBI
Bioorg Med Chem Lett 24: 3600-4 (2014)
Hanyang University
Lead optimization of 1,4-azaindoles as antimycobacterial agents.EBI
J Med Chem 57: 5728-37 (2014)
Astrazeneca
New, potent, and selective peptidic oxytocin receptor agonists.EBI
J Med Chem 57: 5306-17 (2014)
Ferring Research Institute
Design, synthesis, and structure-activity relationship studies of novel thioether pleuromutilin derivatives as potent antibacterial agents.EBI
J Med Chem 57: 4772-95 (2014)
Chinese Academy of Sciences
Structure of REV-ERB▀ ligand-binding domain bound to a porphyrin antagonist.BDB
J Biol Chem 289: 20054-66 (2014)
The Scripps Research Institute
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.EBI
Eur J Med Chem 82: 47-55 (2014)
Medical University of Gdansk
Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold.EBI
Eur J Med Chem 82: 36-46 (2014)
Universit£
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.EBI
Eur J Med Chem 81: 492-8 (2014)
University of Naples
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.EBI
J Med Chem 57: 5419-34 (2014)
Astrazeneca
Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug-resistant anti-tuberculosis agent.EBI
J Med Chem 57: 5293-305 (2014)
Institut Pasteur Korea
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.EBI
J Med Chem 58: 130-46 (2015)
Entremed
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.EBI
J Med Chem 57: 5203-11 (2014)
Lanzhou University
Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists.EBI
Bioorg Med Chem 22: 3654-69 (2014)
Latvian Institute of Organic Synthesis
Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI
Bioorg Med Chem 22: 3720-31 (2014)
Nippon Pharmaceutical Chemicals
4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists.EBI
Eur J Med Chem 82: 1-15 (2014)
Chinese Academy of Sciences
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI
Bioorg Med Chem Lett 24: 3088-91 (2014)
University of Missouri
Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site.BDB
J Biol Chem 289: 19869-80 (2014)
University of Queensland
Aromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors.EBI
Eur J Med Chem 81: 420-6 (2014)
Nanjing University
Guanidinium-based derivatives: searching for new kinase inhibitors.EBI
Eur J Med Chem 81: 427-41 (2014)
Trinity College
Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.EBI
Eur J Med Chem 81: 350-8 (2014)
Instituto De Qu£Mica M£Dica
Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors.EBI
Bioorg Med Chem 22: 3279-84 (2014)
China National Analytical Center (Guangzhou)
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.EBI
J Med Chem 57: 5318-32 (2014)
Research Triangle Institute
Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M1 muscarinic acetylcholine receptor.EBI
J Med Chem 57: 5405-18 (2014)
Monash University (Parkville Campus)
New coumarin derivatives: design, synthesis and use as inhibitors of hMAO.EBI
Bioorg Med Chem 22: 3732-8 (2014)
Anhui Medical University
Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors.EBI
Bioorg Med Chem 22: 3781-90 (2014)
La Trobe University
Inhibition by active site directed covalent modification of human glyoxalase I.EBI
Bioorg Med Chem 22: 3301-8 (2014)
University of Maryland
Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives.EBI
Bioorg Med Chem 22: 3537-43 (2014)
Agriibrahim£E£En University
Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity.EBI
Bioorg Med Chem 22: 3245-51 (2014)
Corbus Pharmaceuticals
Combination of cyclohexane and piperazine based┐-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines.EBI
Bioorg Med Chem 22: 3316-24 (2014)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Pharmacophore based virtual screening, molecular docking and biological evaluation to identify novel PDE5 inhibitors with vasodilatory activity.EBI
Bioorg Med Chem Lett 24: 3137-41 (2014)
Banasthali University
Discovery of N-substituted 7-azaindoline derivatives as potent, orally available M1 and M4 muscarinic acetylcholine receptors selective agonists.EBI
Bioorg Med Chem Lett 24: 3189-93 (2014)
Dainippon Sumitomo Pharma
Targeting the homologous recombination pathway by small molecule modulators.EBI
Bioorg Med Chem Lett 24: 3006-13 (2014)
Drexel University College of Medicine
trans-Caryophyllene is a natural agonistic ligand for peroxisome proliferator-activated receptor-a.EBI
Bioorg Med Chem Lett 24: 3168-74 (2014)
Korea University
Protein-ligand interactions: probing the energetics of a putative cation-? interaction.EBI
Bioorg Med Chem Lett 24: 3164-7 (2014)
The University of Texas
Identification and characterization of a new reversible MAGL inhibitor.EBI
Bioorg Med Chem 22: 3285-91 (2014)
University of Pisa
Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.EBI
Bioorg Med Chem 22: 3370-8 (2014)
Martin-Luther-Universit£T Halle-Wittenberg
Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction.EBI
Eur J Med Chem 81: 277-88 (2014)
Chinese Academy of Medical Science and Peking Union Medical College
Discovery of N-sulfonyl-7-azaindoline derivatives as potent, orally available and selective M(4) muscarinic acetylcholine receptor agonists.EBI
Bioorg Med Chem Lett 24: 2909-12 (2014)
Dainippon Sumitomo Pharma
Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.EBI
J Med Chem 57: 7160-81 (2014)
Universidad Complutense De Madrid
Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists.EBI
J Med Chem 57: 4962-8 (2014)
University of Michigan
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).EBI
J Med Chem 57: 5459-63 (2014)
Takeda California
Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.EBI
J Med Chem 57: 4950-61 (2014)
Johns Hopkins University School of Medicine
Opioid receptor function is regulated by post-endocytic peptide processing.BDB
J Biol Chem 289: 19613-26 (2014)
Icahn School of Medicine At Mount Sinai
Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(a or┐)-thio-(a,▀- or▀,┐)-methylenetriphosphate scaffold.EBI
J Med Chem 57: 4677-91 (2014)
Bar-Ilan University
Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities.EBI
Bioorg Med Chem 22: 3488-97 (2014)
Keio University
Synthesis and▀-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones.EBI
Bioorg Med Chem 22: 3449-54 (2014)
University of Karachi
Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.EBI
J Nat Prod 77: 1445-51 (2014)
University of Tuebingen
Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A.EBI
Bioorg Med Chem Lett 24: 2954-6 (2014)
Georgetown University Medical Center
Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis.EBI
J Med Chem 57: 4692-709 (2014)
Nanjing University
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties.EBI
Bioorg Med Chem 22: 3414-22 (2014)
Amri
Ingol-type diterpenes from Euphorbia antiquorum with mouse 11▀-hydroxysteroid dehydrogenase type 1 inhibition activity.EBI
J Nat Prod 77: 1452-8 (2014)
Lanzhou University
In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated DmtEBI
ACS Med Chem Lett 5: 352-357 (2014)
Vrije Universiteit Brussel
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.EBI
Bioorg Med Chem 22: 3478-87 (2014)
Astellas Pharma
Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures.EBI
Bioorg Med Chem 22: 3508-14 (2014)
Tohoku Pharmaceutical University
Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.EBI
Bioorg Med Chem 22: 3515-26 (2014)
Yamanouchi Pharmaceutical
Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression.EBI
Eur J Med Chem 81: 204-17 (2014)
Jamia Hamdard (Hamdard University)
Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations.EBI
Eur J Med Chem 81: 158-75 (2014)
Ratka Resanovica1
Tamiphosphor monoesters as effective anti-influenza agents.EBI
Eur J Med Chem 81: 106-18 (2014)
National Taiwan University
Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists.EBI
Bioorg Med Chem Lett 24: 2949-53 (2014)
Daiichi Sankyo
Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.EBI
Bioorg Med Chem Lett 24: 2885-91 (2014)
Amgen
Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations.EBI
Bioorg Med Chem Lett 24: 2963-8 (2014)
Astrazeneca
Discovery of TD-4306, a long-acting▀2-agonist for the treatment of asthma and COPD.EBI
Bioorg Med Chem Lett 24: 2871-6 (2014)
Theravance
Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.EBI
Bioorg Med Chem 22: 3341-50 (2014)
Universidad Nacional Del Sur
Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists.EBI
Bioorg Med Chem Lett 24: 3199-203 (2014)
Astrazeneca
Design and synthesis of quinolinopropellane derivatives with selectived opioid receptor agonism.EBI
Bioorg Med Chem Lett 24: 2851-4 (2014)
University of Tsukuba
Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors.EBI
Bioorg Med Chem Lett 24: 2802-6 (2014)
Second Military Medical University
▀-Secretase (BACE1)-inhibiting C-methylrotenoids from Abronia nana suspension cultures.EBI
Bioorg Med Chem Lett 24: 2945-8 (2014)
Kyungpook National University
Small molecule inhibitors targeting activator protein 1 (AP-1).EBI
J Med Chem 57: 6930-48 (2014)
University of Texas Medical Branch
Functionally selective dopamine D2, D3 receptor partial agonists.EBI
J Med Chem 57: 4861-75 (2014)
Friedrich-Alexander University
From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds.EBI
J Med Chem 57: 7145-59 (2014)
Novartis Institutes For Biomedical Research
Functionalization of ▀-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System.BDB
ACS Chem Biol 9: 1499-507 (2014)
University of Bern
ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone.BDB
J Biol Chem 289: 19778-88 (2014)
German Institute of Human Nutrition Potsdam-Rehbruecke
Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.EBI
J Med Chem 57: 4819-33 (2014)
University of Ljubljana
Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.EBI
J Med Chem 57: 5094-111 (2014)
Harvard Medical School
Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor.EBI
J Med Chem 57: 4924-39 (2014)
Monash University
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.EBI
Bioorg Med Chem Lett 24: 2877-80 (2014)
Amgen
Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine.BDB
ACS Chem Biol 9: 1536-44 (2014)
The Broad Institute , Cambridge, Massachusetts 02142, United States
Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors.EBI
J Med Chem 57: 4940-9 (2014)
University of Copenhagen
Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).EBI
Eur J Med Chem 81: 89-94 (2014)
China Pharmaceutical University
Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues ass2 receptor ligands.EBI
J Med Chem 57: 4239-51 (2014)
Washington University
Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds.EBI
Bioorg Med Chem Lett 24: 2924-7 (2014)
Universit£
The dipeptide H-Trp-Glu-OH (WE) shows agonistic activity to peroxisome proliferator-activated protein-a and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells.EBI
Bioorg Med Chem Lett 24: 2957-62 (2014)
Korea University
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.EBI
Eur J Med Chem 81: 15-21 (2014)
University of W£Rzburg
Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents.EBI
Eur J Med Chem 81: 1-14 (2014)
University of Messina
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expoEBI
J Med Chem 57: 4720-44 (2014)
Pfizer
Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition.EBI
J Med Chem 57: 4710-9 (2014)
Institute of Genetics and Molecular and Cellular Biology (Igbmc)
Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.EBI
Bioorg Med Chem 22: 3096-104 (2014)
Gazi University
Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase.EBI
Bioorg Med Chem Lett 24: 2699-702 (2014)
Idenix Pharmaceuticals
Discovery of camphor-derived pyrazolones as 11▀-hydroxysteroid dehydrogenase type 1 inhibitors.EBI
Bioorg Med Chem Lett 24: 2707-11 (2014)
Hoffmann-La Roche
Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.EBI
Bioorg Med Chem Lett 24: 2669-73 (2014)
Chinese Academy of Sciences
8-Substituted 2-alkynyl-N(9)-propargyladenines as A2A adenosine receptor antagonists.EBI
Bioorg Med Chem 22: 3072-82 (2014)
Yamasa
Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.EBI
Bioorg Med Chem 22: 3091-5 (2014)
Hokkaido University
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.EBI
J Med Chem 57: 3966-83 (2014)
Critical Therapeutics
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.EBI
Eur J Med Chem 80: 543-61 (2014)
Okayama University
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.EBI
Bioorg Med Chem Lett 24: 2617-20 (2014)
Universit£
Multivalent design of long-acting▀(2)-adrenoceptor agonists incorporating biarylamines.EBI
Bioorg Med Chem Lett 24: 2625-30 (2014)
Theravance
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.EBI
Bioorg Med Chem Lett 24: 2635-9 (2014)
Array Biopharma
Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.EBI
Bioorg Med Chem Lett 24: 2648-50 (2014)
Second Military Medical University
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.EBI
Bioorg Med Chem Lett 24: 2737-40 (2014)
Merck Research Laboratories
Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKK▀ inhibitors.EBI
Bioorg Med Chem Lett 24: 2655-60 (2014)
Yonsei University
Biased and unbiased strategies to identify biologically active small molecules.EBI
Bioorg Med Chem 22: 4474-89 (2014)
Institut De Chimie Des Substances Naturelles
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.EBI
J Med Chem 57: 4889-905 (2014)
Astrazeneca
Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis.EBI
J Med Chem 57: 5074-84 (2014)
Novartis Institutes For Biomedical Research
Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.EBI
J Med Chem 57: 4834-48 (2014)
Northeastern University
Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells.EBI
J Med Chem 57: 4569-83 (2014)
Georgetown University
Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.EBI
J Med Chem 57: 4543-57 (2014)
Adamed
Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy.EBI
Bioorg Med Chem Lett 24: 2777-80 (2014)
Technical University Graz
Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation.BDB
Chem Biol Drug Des 84: 402-8 (2014)
Institute of Experimental Botany Ascr and Palacky University
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.EBI
J Med Chem 57: 5381-94 (2014)
University of Texas At Dallas
Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors.EBI
J Med Chem 57: 4598-605 (2014)
Universit£
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.EBI
J Med Chem 57: 5370-80 (2014)
University of Alabama At Birmingham
Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.EBI
J Med Chem 57: 4324-36 (2014)
Purdue University
Identification of a new selective dopamine D4 receptor ligand.EBI
Bioorg Med Chem 22: 3105-14 (2014)
Florida A&M University
Development of novel Vitamin D Receptor-Coactivator Inhibitors.EBI
ACS Med Chem Lett 5: 199-204 (2014)
University of Wisconsin-Milwaukee
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.EBI
Hepatology 60: 1015-22 (2014)
Pfizer
Human UTY(KDM6C) is a male-specific N┐-methyl lysyl demethylase.BDB
J Biol Chem 289: 18302-13 (2014)
University of Oxford
Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.EBI
J Nat Prod 77: 1117-22 (2014)
Institut De Chimie Des Substances Naturelles
Synthesis and evaluation of novel marine bromopyrrole alkaloid-based derivatives as potential antidepressant agents.BDB
Chem Biol Drug Des 84: 593-602 (2014)
University of Kwazulu-Natal
Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase.BDB
Chembiochem 15: 1121-30 (2014)
Genentech
Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E2 synthase-1 enzyme (mPGES-1).EBI
Eur J Med Chem 80: 407-15 (2014)
University of Salerno
Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.EBI
Bioorg Med Chem 22: 3213-9 (2014)
Henan University
Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.EBI
Bioorg Med Chem 22: 3187-203 (2014)
Aurigene Discovery Technologies
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.EBI
Bioorg Med Chem 22: 3123-40 (2014)
National Institute of Industrial Technology
Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors.EBI
Bioorg Med Chem 22: 3171-9 (2014)
Kyoto University
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.EBI
Bioorg Med Chem 22: 3146-58 (2014)
South China Normal University
Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs.EBI
Bioorg Med Chem Lett 24: 2693-8 (2014)
Vanderbilt University Medical Center
a-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists.EBI
Bioorg Med Chem Lett 24: 2685-8 (2014)
Seoul National University
Synthesis of 5-methyl phenanthridium derivatives: a new class of human DOPA decarboxylase inhibitors.EBI
Bioorg Med Chem Lett 24: 2712-6 (2014)
Hunan Agricultural University
Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.EBI
Bioorg Med Chem Lett 24: 2764-7 (2014)
Peking University
a-Tetralone derivatives as inhibitors of monoamine oxidase.EBI
Bioorg Med Chem Lett 24: 2758-63 (2014)
North-West University
Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist.EBI
Bioorg Med Chem Lett 24: 2744-8 (2014)
Bristol-Myers Squibb
Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors.EBI
Bioorg Med Chem Lett 24: 2689-92 (2014)
Dainippon Sumitomo Pharma
Structure-activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors.EBI
Eur J Med Chem 80: 383-92 (2014)
Beijing Institute of Technology
Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors.EBI
Eur J Med Chem 80: 364-82 (2014)
Amgen
New 2H-chromene-3-carboxamide derivatives: design, synthesis and use as inhibitors of hMAO.EBI
Eur J Med Chem 80: 278-84 (2014)
Anhui Medical University
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.EBI
J Med Chem 57: 4640-60 (2014)
University of Lille
Sulfonamide inhibition studies of two▀-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.EBI
Bioorg Med Chem 22: 2939-46 (2014)
Kochi Medical School
Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species.EBI
Bioorg Med Chem 22: 2912-8 (2014)
Institute of Biotechnology and Drug Research (Ibwf)
Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity.EBI
Bioorg Med Chem 22: 2947-54 (2014)
Nanjing University
Discovery of novel type II c-Met inhibitors based on BMS-777607.EBI
Eur J Med Chem 80: 254-66 (2014)
Fudan University
Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis.EBI
J Nat Prod 77: 1224-30 (2014)
University of Utah
Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-▀ type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.EBI
J Med Chem 57: 4213-38 (2014)
Ewha Womans University
Synthesis and biological evaluation of a unique heparin mimetic hexasaccharide for structure-activity relationship studies.EBI
J Med Chem 57: 4511-20 (2014)
Momenta Pharmaceuticals
Discovery of novel and selective SIRT6 inhibitors.EBI
J Med Chem 57: 4796-804 (2014)
University of Bologna
Discovery of novel 2,4-diarylaminopyrimidine analogues (DAAPalogues) showing potent inhibitory activities against both wild-type and mutant ALK kinases.EBI
J Med Chem 58: 197-211 (2015)
Chinese Academy of Sciences
Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD.EBI
J Med Chem 57: 4661-76 (2014)
Astrazeneca
Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human a-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants.BDB
ACS Chem Biol 9: 1460-9 (2014)
Tottori University , Yonago 683-8503, Japan
In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.BDB
J Biol Chem 289: 17980-95 (2014)
Harvard School of Public Health
Dual inhibition of thea-glucosidase and butyrylcholinesterase studied by molecular field topology analysis.EBI
Eur J Med Chem 80: 228-42 (2014)
University of Florida
Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors.EBI
Eur J Med Chem 80: 209-17 (2014)
Jamia Hamdard (Hamdard University)
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.EBI
Eur J Med Chem 80: 167-74 (2014)
Shoolini University
Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.EBI
Eur J Med Chem 80: 154-66 (2014)
Roswell Park Cancer Institute
Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.EBI
Bioorg Med Chem Lett 24: 2477-80 (2014)
Genentech
Shuttle-cargo fusion molecules of transport peptides and the hD2/3 receptor antagonist fallypride: a feasible approach to preserve ligand-receptor binding?EBI
J Med Chem 57: 4368-81 (2014)
Mcgill University
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.EBI
J Med Chem 57: 3856-73 (2014)
Gilead Sciences
Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.EBI
Bioorg Med Chem 22: 2919-38 (2014)
Beckman Research Institute
Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.EBI
Bioorg Med Chem Lett 24: 2444-7 (2014)
Viamet Pharmaceuticals
P3 SAR exploration of biphenyl carbamate based Legumain inhibitors.EBI
Bioorg Med Chem Lett 24: 2521-4 (2014)
Queen'S University Belfast
Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives.EBI
Bioorg Med Chem Lett 24: 2424-8 (2014)
Keimyung University
Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.EBI
J Med Chem 57: 4073-87 (2014)
Rikkyo University
Discovery of 4-aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 inhibitors. Part I: optimization of in vitro potencies and pharmacokinetic properties.EBI
J Med Chem 57: 4098-110 (2014)
Development Center For Biotechnology
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.EBI
J Med Chem 57: 4058-72 (2014)
St. John'S University
New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.EBI
Eur J Med Chem 80: 101-11 (2014)
Sapienza University of Rome
Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.EBI
Bioorg Med Chem Lett 24: 2473-6 (2014)
University of Utah
Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors.EBI
Bioorg Med Chem Lett 24: 2486-92 (2014)
Korea Research Institute of Chemical Technology
Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach.EBI
Bioorg Med Chem Lett 24: 2512-6 (2014)
University of Bordeaux
Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.EBI
Bioorg Med Chem Lett 24: 2508-11 (2014)
University of Siena
Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands.EBI
Bioorg Med Chem Lett 24: 2465-8 (2014)
Shandong University
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists.EBI
Bioorg Med Chem Lett 24: 2481-5 (2014)
Bristol-Myers Squibb
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.EBI
Bioorg Med Chem Lett 24: 2448-52 (2014)
Genentech
Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking.EBI
Bioorg Med Chem Lett 24: 2493-6 (2014)
University of Zurich
Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from▀-amino acid as proteasome inhibitors.EBI
Bioorg Med Chem 22: 2955-65 (2014)
Zhejiang University
Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.EBI
J Med Chem 57: 4009-22 (2014)
Taipei Medical University
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.EBI
Eur J Med Chem 80: 47-56 (2014)
National Institute of Pharmaceutical Education and Research
Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties.EBI
Eur J Med Chem 80: 8-35 (2014)
Universit£
Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo.EBI
Eur J Med Chem 79: 436-45 (2014)
University of Helsinki
4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: synthesis, biological evaluation and docking studies.EBI
Eur J Med Chem 79: 413-21 (2014)
Peking University Health Science Center
Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.EBI
Eur J Med Chem 79: 399-412 (2014)
China Pharmaceutical University
Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinity.EBI
J Med Chem 57: 4049-57 (2014)
University of Bath
Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.EBI
Bioorg Med Chem 22: 3030-54 (2014)
University of Oxford
Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia.EBI
J Med Chem 57: 4196-212 (2014)
Janssen Pharmaceutica
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.EBI
J Med Chem 57: 4382-96 (2014)
Northwestern University
Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity.EBI
Bioorg Med Chem 22: 2992-7 (2014)
Rti International
Design, synthesis and preliminary evaluation ofa-sulfonyl┐-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors.EBI
Bioorg Med Chem 22: 3055-64 (2014)
Shandong University
The discovery of diazepinone-based 5-HT3 receptor partial agonists.EBI
Bioorg Med Chem Lett 24: 2578-81 (2014)
Amri
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.EBI
Bioorg Med Chem Lett 24: 2571-7 (2014)
Astrazeneca
Structure-based design and synthesis of bicyclic fused-pyridines as MEK inhibitors.EBI
Bioorg Med Chem Lett 24: 2555-9 (2014)
Shanghai Hengrui Pharmaceutical
Synthesis and structure-activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists.EBI
Bioorg Med Chem Lett 24: 2539-45 (2014)
Bristol-Myers Squibb
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.BDB
Bioorg Chem 55: 2-15 (2014)
University of Ljubljana
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.BDB
J Biol Chem 289: 16349-61 (2014)
University of Colorado School of Medicine
Identification of type II and III DDR2 inhibitors.EBI
J Med Chem 57: 4252-62 (2014)
Technical University of Dortmund
New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury.EBI
J Med Chem 57: 4313-23 (2014)
Universidad Complutense
Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase┐.EBI
J Med Chem 58: 517-21 (2015)
Vertex Pharmaceuticals
Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking.BDB
J Biol Chem 289: 15518-26 (2014)
Central South University
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.BDB
Org Biomol Chem 12: 3441-5 (2014)
Lanzhou University
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.EBI
Bioorg Med Chem 22: 2855-66 (2014)
K.L.E.U'S College of Pharmacy
Cell permeable vanX inhibitors as vancomycin re-sensitizing agents.EBI
Bioorg Med Chem Lett 24: 2535-8 (2014)
University of Minnesota
Hot spot-based design of small-molecule inhibitors for protein-protein interactions.EBI
Bioorg Med Chem Lett 24: 2546-54 (2014)
University of Utah
Discovery of structurally novel, potent and orally efficacious GPR119 agonists.EBI
Bioorg Med Chem Lett 24: 2383-7 (2014)
Genomics Institute of The Novartis Research Foundation
Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.EBI
Bioorg Med Chem Lett 24: 2525-9 (2014)
Chinese Academy of Sciences
Optimization of pancreatic lipase inhibition by Cudrania tricuspidata fruits using response surface methodology.EBI
Bioorg Med Chem Lett 24: 2329-33 (2014)
Chungbuk National University
Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of ??????-amino Acids.BDB
Chem Biol Drug Des 84: 497-504 (2014)
Zhejiang University
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.EBI
J Med Chem 57: 4111-33 (2014)
University of Michigan Medical School
Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.EBI
J Med Chem 57: 4289-301 (2014)
H. Lee Moffitt Cancer Center and Research Institute
Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.EBI
Bioorg Med Chem 22: 2867-74 (2014)
Enscm/Umii/Umr-Cnrs 5635
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.EBI
Bioorg Med Chem 22: 2887-95 (2014)
Sapienza University of Rome
Identification of the first potent, selective and bioavailable PPARa antagonist.EBI
Bioorg Med Chem Lett 24: 2267-72 (2014)
Inception Sciences
Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness.EBI
Bioorg Med Chem Lett 24: 2236-9 (2014)
Johann Wolfgang Goethe University
Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.EBI
Bioorg Med Chem Lett 24: 2263-6 (2014)
Montclair State University
Design, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs.EBI
Bioorg Med Chem Lett 24: 2251-5 (2014)
Banaras Hindu University
Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival.BDB
J Biol Chem 289: 15705-17 (2014)
Dalhousie University
Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.BDB
J Biol Chem 289: 15527-35 (2014)
University of Michigan
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI
Eur J Med Chem 79: 251-9 (2014)
Universit£
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.EBI
J Med Chem 57: 4134-53 (2014)
University of Belgrade
A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group.EBI
J Med Chem 57: 4351-67 (2014)
Showa Pharmaceutical University
Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors.EBI
J Med Chem 57: 3939-65 (2014)
Vichem Chemie
Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.BDB
J Biol Chem 289: 15987-6005 (2014)
University of Wuerzburg
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.EBI
J Med Chem 57: 4273-88 (2014)
Pfizer
New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI
J Med Chem 57: 3773-85 (2014)
Instituto De Qu£Mica M£Dica
Structural basis of pharmacological chaperoning for human ▀-galactosidase.BDB
J Biol Chem 289: 14560-8 (2014)
The University of Tokyo
Elucidation of different inhibition mechanism of small chemicals on PtdInsP-binding domains using in silico docking experiments.EBI
Bioorg Med Chem Lett 24: 2256-62 (2014)
Sookmyung Women'S University
Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic.EBI
Eur J Med Chem 79: 216-30 (2014)
Huazhong University of Science and Technology
Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors.EBI
Eur J Med Chem 79: 203-15 (2014)
Vit University
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-▀ hydrolysis.EBI
Eur J Med Chem 79: 184-93 (2014)
University of Lille
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.EBI
J Med Chem 57: 4154-72 (2014)
Sanford-Burnham Medical Research Institute
The cannabinoid acids, analogs and endogenous counterparts.EBI
Bioorg Med Chem 22: 2830-43 (2014)
The University of Massachusetts Medical School
Synthesis and biological evaluation of compounds which contain pyrazole, thiazole and naphthalene ring as antitumor agents.EBI
Bioorg Med Chem Lett 24: 2324-8 (2014)
Nanjing University
Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.EBI
Bioorg Med Chem Lett 24: 2283-7 (2014)
Bar-Ilan University
Small chemicals with inhibitory effects on PtdIns(3,4,5)P3 binding of Btk PH domain.EBI
Bioorg Med Chem Lett 24: 2334-9 (2014)
Konkuk University
Design, syntheses, and characterization of piperazine based chemokine receptor CCR5 antagonists as anti prostate cancer agents.EBI
Bioorg Med Chem Lett 24: 2319-23 (2014)
Virginia Commonwealth University
Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CBEBI
ACS Med Chem Lett 4: 387-392 (2013)
University of Pittsburgh
Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE).EBI
Eur J Med Chem 79: 128-42 (2014)
Woosuk University
Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.EBI
Bioorg Med Chem Lett 24: 2368-73 (2014)
China Pharmaceutical University
Scaffold hopping approach to a new series of smoothened antagonists.EBI
Bioorg Med Chem Lett 24: 2300-4 (2014)
Soochow University
Syk inhibitors with high potency in presence of blood.EBI
Bioorg Med Chem Lett 24: 2278-82 (2014)
Novartis Institutes For Biomedical Research
Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.EBI
Bioorg Med Chem 22: 2791-8 (2014)
University of Iowa
Preliminary investigations into triazole derived androgen receptor antagonists.EBI
Bioorg Med Chem 22: 2692-706 (2014)
Deakin University
Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.EBI
Bioorg Med Chem Lett 24: 2073-8 (2014)
Glenmark Pharmaceuticals
Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate.EBI
Bioorg Med Chem 22: 2648-54 (2014)
Washington University
Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).EBI
Bioorg Med Chem 22: 2684-91 (2014)
Defence Research & Development Establishment (Drde)
Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.EBI
Eur J Med Chem 79: 34-46 (2014)
North-West University
Synthesis, molecular docking, and biological evaluation of some novel hydrazones and pyrazole derivatives as anti-inflammatory agents.BDB
Chem Biol Drug Des 84: 473-88 (2014)
Cairo University
Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.BDB
J Biol Chem 289: 16270-7 (2014)
Mcgill University
Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors.EBI
Bioorg Med Chem Lett 24: 2118-22 (2014)
Gedeon Richter
Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.EBI
Bioorg Med Chem 22: 2643-7 (2014)
Siedlce University of Natural Sciences and Humanities
Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays.EBI
J Med Chem 57: 3737-45 (2014)
Zhejiang University
4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.EBI
J Med Chem 57: 3874-83 (2014)
National Institute of Diabetes and Digestive and Kidney Diseases
Thienoquinolines as novel disruptors of the PKCe/RACK2 protein-protein interaction.EBI
J Med Chem 57: 3235-46 (2014)
Innsbruck Medical University
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor▀ agonist in clinical trials for the treatment of dyslipidemia.EBI
J Med Chem 57: 3912-23 (2014)
Madrigal Pharmaceuticals
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface.EBI
Bioorg Med Chem Lett 24: 2090-3 (2014)
Fuzhou University
Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.EBI
J Med Chem 57: 3532-45 (2014)
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1.BDB
ACS Chem Biol 9: 1284-93 (2014)
Johns Hopkins University
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.EBI
J Med Chem 57: 6897-918 (2014)
University of Ljubljana
Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth.BDB
BMC Biochem 15: 9 (2014)
International Centre For Genetic Engineering and Biotechnology
Truncated Orexin Peptides: Structure-Activity Relationship Studies.EBI
ACS Med Chem Lett 4: 1224-1227 (2013)
Research Triangle Institute
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.EBI
Eur J Med Chem 78: 455-67 (2014)
University of Strasburg
Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new ROR┐ inhibitors using virtual screening, synthesis and biological evaluation.EBI
Eur J Med Chem 78: 431-41 (2014)
Chinese Academy of Sciences
Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever.EBI
Eur J Med Chem 78: 392-400 (2014)
Universidad Industrial De Santander
4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-▀ type I receptor kinase.EBI
Bioorg Med Chem 22: 2724-32 (2014)
Ewha Womans University
The evolution of amidine-based brain penetrant BACE1 inhibitors.EBI
Bioorg Med Chem Lett 24: 2033-45 (2014)
Janssen Pharmaceutica
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.EBI
Bioorg Med Chem Lett 24: 2079-85 (2014)
Merck Research Laboratories
Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction.EBI
Bioorg Med Chem Lett 24: 2110-4 (2014)
Novartis Institutes For Biomedical Research
Lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 receptor antagonists.EBI
Bioorg Med Chem Lett 24: 2094-7 (2014)
Cephalon
Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.EBI
Bioorg Med Chem 22: 2809-15 (2014)
Hungkuang University
From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor.EBI
Bioorg Med Chem Lett 24: 2212-21 (2014)
Argenta Discovery
RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.EBI
Bioorg Med Chem 22: 2771-82 (2014)
Japan Science and Technology Agency
Search for novel histone deacetylase inhibitors. Part II: design and synthesis of novel isoferulic acid derivatives.EBI
Bioorg Med Chem 22: 2707-13 (2014)
Xi'An Jiaotong University
Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (ROR┐)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.EBI
Bioorg Med Chem 22: 2799-808 (2014)
The University of Tokyo
Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.EBI
J Med Chem 57: 3588-93 (2014)
Chinese Academy of Sciences (Cas)
Biased ligand modulation of seven transmembrane receptors (7TMRs): functional implications for drug discovery.EBI
J Med Chem 57: 6887-96 (2014)
Merck Research Laboratories
Novel derivatives of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with improved fluorescent ands receptors binding properties.EBI
J Med Chem 57: 3314-23 (2014)
Universit£
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.EBI
J Med Chem 57: 3746-54 (2014)
University of Texas Southwestern Medical Center
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.EBI
J Med Chem 57: 3283-94 (2014)
Fred Hutchinson Cancer Research Center
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.EBI
J Med Chem 57: 3715-23 (2014)
Friedrich-Schiller-University
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.BDB
J Biol Chem 289: 13042-53 (2014)
Harvard Neurodiscovery Center
Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.EBI
J Med Chem 57: 3845-55 (2014)
Pfizer
New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile.EBI
J Med Chem 57: 4487-97 (2014)
Micurx Pharmaceuticals
Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI
J Med Chem 57: 3324-41 (2014)
Shandong University
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor ▀/d (FABP5-PPAR▀/d) signaling pathway.BDB
J Biol Chem 289: 14941-54 (2014)
Emory University
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.EBI
Eur J Med Chem 78: 324-39 (2014)
Jagiellonian University Medical College
a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.EBI
Bioorg Med Chem 22: 2763-70 (2014)
The Scripps Research Institute
Antagonists of the kappa opioid receptor.EBI
Bioorg Med Chem Lett 24: 2021-32 (2014)
The Scripps Research Institute
Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors.EBI
J Med Chem 57: 3494-510 (2014)
Universidad De Santiago De Compostela
Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.EBI
J Med Chem 57: 3522-31 (2014)
Griffith University
Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).EBI
J Med Chem 57: 3570-87 (2014)
Mrc Technology
Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II.EBI
Eur J Med Chem 78: 294-303 (2014)
National University of Singapore
Identification of tertiary sulfonamides as RORc inverse agonists.EBI
Bioorg Med Chem Lett 24: 2182-7 (2014)
Genentech
Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators.EBI
Bioorg Med Chem Lett 24: 2168-72 (2014)
Emd-Serono Research Institute
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.EBI
Bioorg Med Chem Lett 24: 2206-11 (2014)
Bristol-Myers Squibb Research and Development
Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors.EBI
Bioorg Med Chem Lett 24: 2193-7 (2014)
Volzhsky Polytechnic Institute (Branch) Volgograd State Technical University
The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2.EBI
Bioorg Med Chem Lett 24: 2137-40 (2014)
Janssen Research and Development
Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors.EBI
Bioorg Med Chem 22: 2396-402 (2014)
Peking University
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR).EBI
Bioorg Med Chem 22: 2447-60 (2014)
Goethe-University Frankfurt
Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors.BDB
Bioorg Med Chem Lett 24: 1889-94 (2014)
Jiangnan University
In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma.EBI
Bioorg Med Chem Lett 24: 1875-9 (2014)
Alcon Laboratories
Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C┐ and┐ from typical C1 domains.EBI
J Med Chem 57: 3835-44 (2014)
National Cancer Institute-Bethesda
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.EBI
J Med Chem 57: 3223-34 (2014)
Sapienza University of Rome
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.EBI
J Med Chem 57: 4035-48 (2014)
Harvard Medical School
Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines.EBI
Eur J Med Chem 78: 217-24 (2014)
Siedlce University of Natural Sciences and Humanities
Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.EBI
Eur J Med Chem 78: 167-77 (2014)
Quaid-I-Azam University
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.EBI
Eur J Med Chem 78: 157-66 (2014)
University of Bologna
New aminobenzenesulfonamide-thiourea conjugates: synthesis and carbonic anhydrase inhibition and docking studies.EBI
Eur J Med Chem 78: 140-50 (2014)
Comsats Institute of Information Technology
Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors.EBI
Eur J Med Chem 78: 106-17 (2014)
Government College Women University
Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.EBI
Eur J Med Chem 78: 65-71 (2014)
Sun Yat-Sen University
Effect of prime-site sequence of retro-inverso-modified HTLV-1 protease inhibitor.EBI
Bioorg Med Chem 22: 2482-8 (2014)
Kyoto Prefectural University of Medicine
Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors.EBI
Bioorg Med Chem 22: 2535-41 (2014)
Fudan University
Anti-inflammatory components of Euphorbia humifusa Willd.EBI
Bioorg Med Chem Lett 24: 1895-900 (2014)
Chungnam National University
Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.EBI
J Med Chem 57: 3418-29 (2014)
Eli Lilly
Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.EBI
J Med Chem 57: 3358-68 (2014)
Novartis Institutes For Biomedical Research
Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity.BDB
Chembiochem 15: 701-712 (2014)
Indiana University
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.EBI
Bioorg Med Chem Lett 24: 1923-7 (2014)
Array Biopharma
Identification of novel SIRT2-selective inhibitors using a click chemistry approach.EBI
Bioorg Med Chem Lett 24: 1871-4 (2014)
Nagoya City University
Design, synthesis and biological evaluation of novel aminomethyl-piperidones based DPP-IV inhibitors.EBI
Bioorg Med Chem Lett 24: 1918-22 (2014)
M.S. University of Baroda
Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.EBI
Eur J Med Chem 78: 43-53 (2014)
Quaid-I-Azam University
Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.EBI
Eur J Med Chem 78: 10-22 (2014)
Jagiellonian University Medical College
Synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.EBI
Eur J Med Chem 78: 1-9 (2014)
South Dakota State University
Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.EBI
Eur J Med Chem 77: 361-77 (2014)
Harvard Medical School
Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents.EBI
Eur J Med Chem 77: 351-60 (2014)
Peking Union Medical College & Chinese Academy of Medical Sciences
Identification of dipeptidyl peptidase IV inhibitors: virtual screening, synthesis and biological evaluation.BDB
Chem Biol Drug Des 84: 364-77 (2014)
China Pharmaceutical University
Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.EBI
J Med Chem 57: 3484-93 (2014)
Genentech
Identification of novel HSP90a/▀ isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.EBI
J Med Chem 57: 3382-400 (2014)
Vertex Pharmaceuticals
Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents.EBI
J Med Chem 57: 3464-83 (2014)
Amgen
Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.EBI
J Med Chem 57: 3213-22 (2014)
Leiden University
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.BDB
J Biol Chem 289: 13717-25 (2014)
National Institutes of Health
Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.EBI
Bioorg Med Chem Lett 24: 1968-73 (2014)
Merck
Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.EBI
J Med Chem 57: 3263-82 (2014)
Genomics Institute of The Novartis Research Foundation
Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors.EBI
J Med Chem 57: 3559-69 (2014)
Virginia Commonwealth University
Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.EBI
J Med Chem 57: 3450-63 (2014)
National Center For Advancing Translational Sciences
Synthesis of thio-heterocyclic analogues from Baylis-Hillman bromides as potent cyclooxygenase-2 inhibitors.EBI
Bioorg Med Chem Lett 24: 1952-7 (2014)
Csir-Indian Institute of Chemical Technology
Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.EBI
J Med Chem 57: 3205-12 (2014)
Merck
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity.EBI
J Med Chem 57: 3011-29 (2014)
University of Florida
An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.EBI
ACS Med Chem Lett 5: 56-60 (2014)
Northwestern University
Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.EBI
Eur J Med Chem 77: 306-14 (2014)
Taipei Medical University
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.EBI
Bioorg Med Chem 22: 2508-16 (2014)
Astraea Therapeutics
Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.EBI
Bioorg Med Chem 22: 2435-41 (2014)
University of Toyama
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.EBI
Bioorg Med Chem 22: 2496-507 (2014)
Universit£
Polyfluorinated bis-styrylbenzenes as amyloid-▀ plaque binding ligands.EBI
Bioorg Med Chem 22: 2469-81 (2014)
Leiden University
1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.EBI
Bioorg Med Chem 22: 2416-26 (2014)
Tianjin University of Science and Technology
Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography.EBI
Bioorg Med Chem 22: 2427-34 (2014)
Astellas Pharma
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI
Bioorg Med Chem Lett 24: 1958-62 (2014)
Kyung Hee University
Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.EBI
Bioorg Med Chem Lett 24: 1983-6 (2014)
Merck Research Laboratories
Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.EBI
Bioorg Med Chem Lett 24: 1934-40 (2014)
Boehringer Ingelheim Pharmaceuticals
Pharmacophoric modifications lead to superpotentav▀3 integrin ligands with suppresseda5▀1 activity.EBI
J Med Chem 57: 3410-7 (2014)
Technische Universit£T M£Nchen
New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors.EBI
J Med Chem 57: 3247-62 (2014)
Universit£
Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties.EBI
Eur J Med Chem 77: 269-79 (2014)
United Arab Emirates University
Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors.EBI
Bioorg Med Chem 22: 2253-60 (2014)
Rockefeller University
Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.EBI
Bioorg Med Chem 22: 2529-34 (2014)
Keio University
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.EBI
Bioorg Med Chem Lett 24: 1941-3 (2014)
Universit£
Discovery of 4-anilinoa-carbolines as novel Brk inhibitors.EBI
Bioorg Med Chem Lett 24: 1948-51 (2014)
Martin-Luther-University Halle-Wittenberg
Discovery of a potent and selectivea3▀4 nicotinic acetylcholine receptor antagonist from ana-conotoxin synthetic combinatorial library.EBI
J Med Chem 57: 3511-21 (2014)
Torrey Pines Institute For Molecular Studies
Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors.EBI
J Med Chem 57: 3154-60 (2014)
Utrecht University
Chiral Effect of a Phe Residue in Position 3 of the DmtEBI
ACS Med Chem Lett 4: 656-659 (2013)
University of Arizona
Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance.BDB
J Biol Chem 289: 13273-83 (2014)
St. Paul'S Hospital'S Centre of Heart and Lung Innovation
Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor ▀/d (PPAR▀/d) in the brain.BDB
J Biol Chem 289: 12748-58 (2014)
Case Western Reserve University School of Medicine
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H.EBI
Eur J Med Chem 77: 231-42 (2014)
Kurukshetra University
1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.BDB
Chem Biol Drug Des 84: 270-81 (2014)
University of Massachusetts Boston
Development of a bioavailableÁ opioid receptor (MOPr) agonist,d opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.EBI
J Med Chem 57: 3148-53 (2014)
University of Michigan
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.EBI
J Med Chem 57: 3430-49 (2014)
Amgen
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).EBI
J Med Chem 57: 2773-88 (2014)
Imperial College
Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.EBI
Bioorg Med Chem Lett 24: 1657-60 (2014)
Merck Research Laboratories
Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study.BDB
Chem Biol Drug Des 84: 409-19 (2014)
Y.B. Chavan College of Pharmacy
Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors.BDB
Chem Biol Drug Des 83: 498-506 (2014)
Birla Institute of Technology
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.BDB
J Biol Chem 289: 12177-88 (2014)
University of Toronto
A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model.BDB
J Biol Chem 289: 12457-66 (2014)
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives.BDB
Bioorg Chem 53: 75-82 (2014)
University of Delhi
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.EBI
Eur J Med Chem 77: 185-92 (2014)
Guru Nanak Dev University
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.EBI
Eur J Med Chem 77: 155-65 (2014)
Minia University
Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles.EBI
Eur J Med Chem 77: 91-5 (2014)
Universitat Pompeu Fabra
Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.EBI
Bioorg Med Chem 22: 2080-9 (2014)
Cairo University
Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives.EBI
Bioorg Med Chem 22: 2052-9 (2014)
Shandong University
N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs.EBI
Bioorg Med Chem 22: 2133-40 (2014)
Polish Academy of Sciences
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.EBI
Bioorg Med Chem Lett 24: 1820-4 (2014)
Astrazeneca
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.EBI
Bioorg Med Chem Lett 24: 1698-701 (2014)
Kyoto Pharmaceutical University
Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation.EBI
Bioorg Med Chem 22: 2194-207 (2014)
Aristotle University of Thessaloniki
Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character.EBI
Bioorg Med Chem 22: 2244-52 (2014)
The University of Tokyo
Some non-conventional biomolecular targets for diamidines. A short survey.EBI
Bioorg Med Chem 22: 1983-92 (2014)
Xavier University of Louisiana
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.EBI
Bioorg Med Chem Lett 24: 1784-9 (2014)
Merck Research Laboratories
Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component.EBI
Bioorg Med Chem Lett 24: 1730-3 (2014)
Hanyang University
Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.EBI
Bioorg Med Chem Lett 24: 1711-4 (2014)
Southwest Research Institute
Schiff's base derivatives bearing nitroimidazole and quinoline nuclei: new class of anticancer agents and potential EGFR tyrosine kinase inhibitors.EBI
Bioorg Med Chem Lett 24: 1734-6 (2014)
Nanjing University
Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.EBI
Bioorg Med Chem Lett 24: 1681-4 (2014)
Merck Research Laboratories
Computer-aided identification of novel 3,5-substituted rhodanine derivatives with activity against Staphylococcus aureus DNA gyrase.EBI
Bioorg Med Chem 22: 2176-87 (2014)
University of The Sciences
Synthetic approaches to the 2012 new drugs.EBI
Bioorg Med Chem 22: 2005-32 (2014)
Pharmaphase
Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.EBI
J Med Chem 57: 2908-19 (2014)
University of Strasburg
Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).EBI
J Med Chem 57: 2874-83 (2014)
University of Victoria
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.EBI
Bioorg Med Chem 22: 2269-79 (2014)
Universit£
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.EBI
Bioorg Med Chem Lett 24: 1790-4 (2014)
Merck Research Laboratories
Synthesis and biological evaluation of a series of benzoxazole/benzothiazole-containing 2,3-dihydrobenzo[b][1,4]dioxine derivatives as potential antidepressants.EBI
Bioorg Med Chem Lett 24: 1766-70 (2014)
Huazhong University of Science and Technology
Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP).EBI
J Med Chem 57: 3053-74 (2014)
University of Antwerp
Synthesis, pharmacological evaluation, ands1 receptor interaction analysis of hydroxyethyl substituted piperazines.EBI
J Med Chem 57: 2884-94 (2014)
University of M£Nster
Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression.EBI
Bioorg Med Chem Lett 24: 1846-50 (2014)
Norwegian Medical Cyclotron Centre
Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity.EBI
Bioorg Med Chem 22: 2236-43 (2014)
Chinese Academy of Sciences
Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.EBI
Bioorg Med Chem 22: 2311-9 (2014)
Medical University Vienna
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.EBI
Bioorg Med Chem 22: 2157-65 (2014)
St. Jude Children'S Research Hospital
Endomorphin analogues with mixedÁ-opioid (MOP) receptor agonism/d-opioid (DOP) receptor antagonism and lacking▀-arrestin2 recruitment activity.EBI
Bioorg Med Chem 22: 2208-19 (2014)
Nanjing Medical University
Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.EBI
Bioorg Med Chem Lett 24: 1843-5 (2014)
Bristol-Myers Squibb
Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.EBI
Bioorg Med Chem 22: 2339-52 (2014)
Hiroshima International University
Discovery of novel secretory phospholipase A2 inhibitors using virtual screen.BDB
Chem Biol Drug Des 84: 216-22 (2014)
Peking University
Symmetric bis-chalcones as a new type of breast cancer resistance protein inhibitors with a mechanism different from that of chromones.EBI
J Med Chem 57: 2930-41 (2014)
Bmssi Umr 5086 Cnrs/Universit£
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.EBI
J Med Chem 57: 3094-116 (2014)
Amgen
Discovery of ML314, a Brain Penetrant Non-Peptidic?-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.EBI
ACS Med Chem Lett 4: 846-851 (2013)
Sanford-Burnham Medical Research Institute
Thrombin inhibitory activity of some polyphenolic compounds.EBI
Med Chem Res 23: 2324-2337 (2014)
University of Lodz
New synthesis of 3-(▀-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase.EBI
Eur J Med Chem 76: 567-79 (2014)
University of Debrecen
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.EBI
Eur J Med Chem 76: 558-66 (2014)
Universit£
Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents.EBI
Eur J Med Chem 76: 549-57 (2014)
Nanjing University
Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents.EBI
Eur J Med Chem 76: 482-93 (2014)
Cairo University
Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors.EBI
Eur J Med Chem 77: 75-83 (2014)
China Pharmaceutical University
Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis.BDB
Bioorg Chem 53: 67-74 (2014)
Swami Ramanand Teerth Marathwada University
Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.EBI
J Nat Prod 77: 894-901 (2014)
University of Wollongong
Fragment-based identification of an inducible binding site on cell surface receptor CD44 for the design of protein-carbohydrate interaction inhibitors.EBI
J Med Chem 57: 2714-25 (2014)
University of Minnesota
Evaluation of bisindole as potent▀-glucuronidase inhibitors: synthesis and in silico based studies.EBI
Bioorg Med Chem Lett 24: 1825-9 (2014)
University of Karachi
Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.EBI
Eur J Med Chem 76: 531-8 (2014)
Shandong University
Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 76: 506-16 (2014)
University of Kansas
Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents.EBI
Eur J Med Chem 76: 494-505 (2014)
Asbasjsm College of Pharmacy
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.EBI
Eur J Med Chem 76: 414-26 (2014)
Northwestern University
[Dmt(1)]DALDA analogues with enhancedÁ opioid agonist potency and with a mixedÁ/┐ opioid activity profile.EBI
Bioorg Med Chem 22: 2333-8 (2014)
Nanjing Medical University
Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex.EBI
J Nat Prod 77: 963-8 (2014)
Meiji Pharmaceutical University
Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.EBI
J Med Chem 57: 2963-88 (2014)
Amgen
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis.EBI
J Med Chem 57: 2942-52 (2014)
University College London
The SAMPL4 host-guest blind prediction challenge: an overview.BDB
J Comput Aided Mol Des 28: 305-17 (2014)
University of California San Diego
Prenylated coumarins: natural phosphodiesterase-4 inhibitors from Toddalia asiatica.EBI
J Nat Prod 77: 955-62 (2014)
Sun Yat-Sen University
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.EBI
J Med Chem 57: 2989-3004 (2014)
Amgen
Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.EBI
Eur J Med Chem 76: 376-86 (2014)
Southeast University
Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.EBI
Bioorg Med Chem Lett 24: 1815-9 (2014)
Universiti Sains Malaysia
Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.EBI
Bioorg Med Chem 22: 2353-65 (2014)
Glaxosmithkline
Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera.EBI
J Nat Prod 77: 807-12 (2014)
Chinese Academy of Sciences
Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors.EBI
J Med Chem 57: 2813-9 (2014)
University of Nottingham
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.EBI
J Med Chem 57: 2755-72 (2014)
Csic
Cathepsin C inhibitors: property optimization and identification of a clinical candidate.EBI
J Med Chem 57: 2357-67 (2014)
Astrazeneca
Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.EBI
Bioorg Med Chem Lett 24: 1776-9 (2014)
University of Cagliari
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 76: 314-31 (2014)
Sichuan University
Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.EBI
Eur J Med Chem 76: 301-13 (2014)
Tohoku Pharmaceutical University
4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII.EBI
Eur J Med Chem 76: 284-90 (2014)
Kurukshetra University
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.EBI
Bioorg Med Chem 22: 2280-93 (2014)
Yuhan Research Institute
Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).EBI
Bioorg Med Chem 22: 2261-8 (2014)
Astrazeneca
Biologically active eremophilane-type sesquiterpenes from Camarops sp., an endophytic fungus isolated from Alibertia macrophylla.EBI
J Nat Prod 77: 668-72 (2014)
Universidade Estadual Paulista
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI
J Med Chem 57: 2258-74 (2014)
Universit£
Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib.EBI
J Med Chem 57: 2692-703 (2014)
Chinese Academy of Sciences
Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPAR┐.EBI
Eur J Med Chem 76: 182-92 (2014)
Chinese Academy of Medical Sciences & Peking Union Medical College
Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: synthetic approaches and multifarious applications.EBI
Eur J Med Chem 76: 193-244 (2014)
Quaid-I-Azam University
The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-▀-lactamases and arginases.EBI
Eur J Med Chem 76: 132-44 (2014)
The University of Queensland
Homoisoflavonoids as potential imaging agents for ?-amyloid plaques in Alzheimer's disease.EBI
Eur J Med Chem 76: 125-31 (2014)
Hefei University of Technology
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.EBI
Bioorg Med Chem Lett 24: 1466-71 (2014)
Merck
Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.EBI
Bioorg Med Chem Lett 24: 1484-8 (2014)
Research & Development, Abbvie
5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.EBI
Bioorg Med Chem Lett 24: 1489-92 (2014)
Virginia Commonwealth University
Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.EBI
Bioorg Med Chem Lett 24: 1557-61 (2014)
China Pharmaceutical University
cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists.EBI
Bioorg Med Chem Lett 24: 1458-61 (2014)
Lundbeck Research Usa
Interaction kinetics of liposome-incorporated unsaturated fatty acids with fatty acid-binding protein 3 by surface plasmon resonance.EBI
Bioorg Med Chem 22: 1804-8 (2014)
Osaka University
Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.EBI
Bioorg Med Chem 22: 1863-72 (2014)
Shandong University
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.EBI
J Med Chem 57: 2413-28 (2014)
Universit£
Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.EBI
J Med Chem 57: 2524-35 (2014)
University of Geneva
Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.EBI
Eur J Med Chem 87: 868-80 (2014)
National Research Centre, Dokki
Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus.EBI
J Nat Prod 77: 1021-30 (2014)
Peking University
Targeting carnitine biosynthesis: discovery of new inhibitors against┐-butyrobetaine hydroxylase.EBI
J Med Chem 57: 2213-36 (2014)
Latvian Biomedical Research and Study Centre
Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk.EBI
Bioorg Med Chem Lett 24: 1523-7 (2014)
University of Zurich
Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists.EBI
J Med Chem 57: 6301-15 (2014)
University of Bradford
Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.EBI
J Med Chem 57: 2643-56 (2014)
University of Connecticut
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.EBI
J Med Chem 57: 2568-81 (2014)
University of Athens
Multitarget drug discovery for tuberculosis and other infectious diseases.EBI
J Med Chem 57: 3126-39 (2014)
University of Illinois At Urbana-Champaign
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.EBI
J Med Chem 57: 2549-67 (2014)
Universitat De Barcelona
X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.EBI
J Med Chem 57: 2393-412 (2014)
Purdue University
Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: from lead to clinical compound.EBI
J Med Chem 57: 2058-73 (2014)
Glaxosmithkline
wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.EBI
J Med Chem 57: 2498-510 (2014)
University Hospital of Bonn
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.EBI
J Nat Prod 77: 441-5 (2014)
University of Athens
Development of novel tetrahydrothieno[2,3-c]pyridine-3-carboxamide based Mycobacterium tuberculosis pantothenate synthetase inhibitors: molecular hybridization from known antimycobacterial leads.EBI
Bioorg Med Chem 22: 1938-47 (2014)
Birla Institute of Technology
Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.EBI
Bioorg Med Chem 22: 2366-78 (2014)
Chinese Academy of Sciences
Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells.EBI
Bioorg Med Chem 22: 1809-20 (2014)
Konkuk University
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI
Eur J Med Chem 76: 53-60 (2014)
Universit£
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.EBI
J Med Chem 57: 2611-22 (2014)
The University of Georgia
Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility.EBI
J Med Chem 57: 3687-706 (2014)
Chinese Academy of Sciences
Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc.EBI
ACS Med Chem Lett 5: 133-137 (2014)
The Scripps Research Institute
Identification of a new series of amides as non-covalent proteasome inhibitors.EBI
Eur J Med Chem 76: 1-9 (2014)
Universit£
Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII.EBI
Bioorg Med Chem 22: 1821-31 (2014)
Sapienza University of Rome
Alkynyl-coumarinyl ethers as MAO-B inhibitors.EBI
Bioorg Med Chem 22: 1916-28 (2014)
University of Bonn
Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII.EBI
Bioorg Med Chem 22: 1873-82 (2014)
Kurukshetra University
Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3K▀ inhibitors.EBI
Bioorg Med Chem Lett 24: 1506-10 (2014)
Sanofi
Discovery of 1,3,4-oxidiazole scaffold compounds as inhibitors of superoxide dismutase expression.EBI
Bioorg Med Chem Lett 24: 1532-7 (2014)
Northwestern University
Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET.EBI
Bioorg Med Chem Lett 24: 1550-6 (2014)
Cea
Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors.EBI
Bioorg Med Chem 22: 1948-59 (2014)
The University of Tokyo
Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents.EBI
Bioorg Med Chem Lett 24: 1538-44 (2014)
University of Michigan
A perspective on natural products research and ethnopharmacology in Mexico: the eagle and the serpent on the prickly pear cactus.EBI
J Nat Prod 77: 678-89 (2014)
University of London
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.EBI
J Med Chem 57: 2670-82 (2014)
Intra-Cellular Therapies
Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase.EBI
Bioorg Med Chem Lett 24: 1545-9 (2014)
Universidad De Buenos Aires
Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties.EBI
Bioorg Med Chem Lett 24: 1615-20 (2014)
Merck Research Laboratories
Synthesis of novel l-rhamnose derived acyclic C-nucleosides with substituted 1,2,3-triazole core as potent sodium-glucose co-transporter (SGLT) inhibitors.EBI
Bioorg Med Chem Lett 24: 1528-31 (2014)
Csir-Indian Institute of Chemical Technology
Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity.EBI
Eur J Med Chem 75: 327-35 (2014)
Panjab University
Monovalent mannose-based DC-SIGN antagonists: targeting the hydrophobic groove of the receptor.EBI
Eur J Med Chem 75: 308-26 (2014)
University of Ljubljana
Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors.EBI
Eur J Med Chem 75: 289-96 (2014)
Hainan University
Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.EBI
J Med Chem 57: 1708-29 (2014)
Bristol-Myers Squibb Research and Development
Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.EBI
J Med Chem 57: 2472-88 (2014)
Amgen
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.EBI
J Med Chem 57: 1188-207 (2014)
Memorial Sloan-Kettering Cancer Center
Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria.EBI
J Nat Prod 77: 364-9 (2014)
University of Troms£
Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.EBI
Eur J Med Chem 75: 222-32 (2014)
Universit£
New C(4)- and C(1)-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform.EBI
Bioorg Med Chem Lett 24: 1571-80 (2014)
Yerevan State University
2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.EBI
Bioorg Med Chem Lett 24: 1592-6 (2014)
Novartis Institutes For Biomedical Research
Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.EBI
J Med Chem 57: 2380-92 (2014)
Universidade De S£O Paulo
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.EBI
Eur J Med Chem 75: 169-83 (2014)
Universit£
New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies.EBI
Eur J Med Chem 75: 159-68 (2014)
Universit£
Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.EBI
Eur J Med Chem 75: 111-22 (2014)
Shenyang Pharmaceutical University
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.EBI
Eur J Med Chem 74: 606-18 (2014)
University of Bari "A. Moro
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.EBI
Eur J Med Chem 75: 82-95 (2014)
Laboratorio De Quimica Medica (Iqog, Csic)
Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.EBI
Bioorg Med Chem 22: 1909-15 (2014)
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action.EBI
Bioorg Med Chem 22: 1548-57 (2014)
Dainippon Sumitomo Pharma
Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.EBI
Bioorg Med Chem 22: 1850-62 (2014)
Chinese Academy of Medical Sciences & Peking Union Medical College
Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist.EBI
Bioorg Med Chem Lett 24: 1565-70 (2014)
Kyung Hee University
Synthesis of 2,6-disubstituted benzylamine derivatives as reversible selective inhibitors of copper amine oxidases.EBI
Bioorg Med Chem 22: 1558-67 (2014)
Universit£
1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators.EBI
J Med Chem 57: 2462-71 (2014)
Pfizer
Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors.EBI
J Med Chem 57: 2807-12 (2014)
Universit£
The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.EBI
J Med Chem 57: 2601-10 (2014)
Merck Research Laboratories
Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors.EBI
Bioorg Med Chem 22: 1529-38 (2014)
Shandong University
Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.EBI
J Med Chem 57: 2726-35 (2014)
Hokkaido University
Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif.BDB
J Biol Chem 289: 8839-51 (2014)
Karlsruhe Institute of Technology
Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.EBI
J Med Chem 57: 2013-32 (2014)
Bristol-Myers Squibb Research and Development
Isolation of arginase inhibitors from the bioactivity-guided fractionation of Byrsonima coccolobifolia leaves and stems.EBI
J Nat Prod 77: 392-6 (2014)
Universidade Federal De S£O Carlos
Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents.EBI
J Nat Prod 77: 650-6 (2014)
Universidade Estadual Paulista (Unesp)
Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells.EBI
J Med Chem 57: 2292-302 (2014)
National Cancer Institute-Frederick
2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors.EBI
J Med Chem 57: 2953-62 (2014)
Universit£
Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.EBI
J Med Chem 57: 2683-91 (2014)
Hoffmann-La Roche
Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase.EBI
J Med Chem 57: 2582-8 (2014)
Eisai
1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.EBI
Eur J Med Chem 74: 524-32 (2014)
Universit£
Discovery of simplified N▓-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies.EBI
Bioorg Med Chem 22: 1751-65 (2014)
National University of Singapore
6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.EBI
Bioorg Med Chem Lett 24: 1256-60 (2014)
Latvian Institute of Organic Synthesis
Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).EBI
J Med Chem 57: 4615-28 (2014)
University of Florida
Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition.EBI
J Med Chem 57: 5835-44 (2014)
The University of Arizona
Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).EBI
J Med Chem 57: 1495-512 (2014)
Purdue University
Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists.EBI
Bioorg Med Chem 22: 1596-607 (2014)
East China University of Science and Technology
Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.EBI
Bioorg Med Chem 22: 1522-8 (2014)
Latvian Institute of Organic Synthesis
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.EBI
Bioorg Med Chem 22: 1586-95 (2014)
Birla Institute of Technology
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.EBI
Bioorg Med Chem Lett 24: 1280-4 (2014)
Janssen Pharmaceutical Companies of Johnson & Johnson
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel.EBI
Bioorg Med Chem Lett 24: 1269-73 (2014)
Astrazeneca
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.EBI
Bioorg Med Chem Lett 24: 1294-8 (2014)
Bristol-Myers Squibb
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.EBI
Bioorg Med Chem Lett 24: 1303-6 (2014)
Teva Pharmaceutical Global R & D
Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.EBI
J Med Chem 57: 2334-56 (2014)
Emory University
Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.EBI
J Med Chem 57: 2736-45 (2014)
China Pharmaceutical University
Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.EBI
J Med Chem 57: 1299-322 (2014)
Pfizer
Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.EBI
Eur J Med Chem 75: 21-30 (2014)
Khon Kaen University
Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: toward the discovery of novel Akt1 inhibitors.EBI
Eur J Med Chem 75: 11-20 (2014)
Zhejiang University
Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists.EBI
Bioorg Med Chem 22: 1649-66 (2014)
Takeda Pharmaceutical
Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.EBI
Bioorg Med Chem 22: 1642-8 (2014)
Guru Nanak Dev University
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT? receptor.EBI
Bioorg Med Chem 22: 1736-50 (2014)
Universit£
Syntheses and structure-activity relationships for some triazolyl p38? MAPK inhibitors.EBI
Bioorg Med Chem Lett 24: 1352-7 (2014)
Syncom
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