Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50044411
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.0860nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKi:  0.133nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.134nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50004813(8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-methyl-1-phe...)
Affinity DataKi:  0.265nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50400512(CHEMBL2203405)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL540612 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM123850(US8748608, 34 Enantiomer B | US8748608, 34 Enantio...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016453(CHEMBL3265063)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50366495(CHEMBL1255588 | (+)butaclamol)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016462(CHEMBL3265067)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016462(CHEMBL3265067)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016453(CHEMBL3265063)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50366495(CHEMBL1255588 | (+)butaclamol)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50219105(N-(3-hydroxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50119380(CHEMBL540612 | N-(4-(4-(2-methoxyphenyl)piperazin-...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recrui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016447(CHEMBL3265064)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016447(CHEMBL3265064)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016444(CHEMBL3265065)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016444(CHEMBL3265065)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016464(CHEMBL3265062)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50312273((1R,5S/1S,5R)-1-[2-Fluoro-4-(trifluoromethyl)pheny...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016465(CHEMBL3265061)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016462(CHEMBL3265067)
Affinity DataIC50: 327nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in human U2OS cells assessed as inhibition of pramipexole-stimulated beta-arrestin recrui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016463(CHEMBL3265066)
Affinity DataKi:  457nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016462(CHEMBL3265067)
Affinity DataKi:  623nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016453(CHEMBL3265063)
Affinity DataKi:  667nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM123850(US8748608, 34 Enantiomer B | US8748608, 34 Enantio...)
Affinity DataKi:  746nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016447(CHEMBL3265064)
Affinity DataKi:  923nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50219105(N-(3-hydroxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)...)
Affinity DataKi:  1.09E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016467(CHEMBL3265059)
Affinity DataKi:  1.17E+3nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016466(CHEMBL3265060)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50016444(CHEMBL3265065)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50240772((1R,2S)-2-phenylcyclopropanamine | cid_2723716 | (...)
Affinity DataKi:  1.28E+4nMAssay Description:Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed