Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50044057
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50442881(SILYBIN A)
Affinity DataKd:  1.90nMAssay Description:Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50241503(CHEMBL404515 | CHEMBL511367 | 2-(3,4-dihydroxyphen...)
Affinity DataKd:  7.80nMAssay Description:Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataKd:  38.7nMAssay Description:Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50241503(CHEMBL404515 | CHEMBL511367 | 2-(3,4-dihydroxyphen...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of urokinase amidolytic activity (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50442881(SILYBIN A)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of thrombin (unknown origin) assessed as hydrolysis of N-benzoyl-phenylalanylvalyl-arginine-paranitroanilideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50442881(SILYBIN A)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of urokinase amidolytic activity (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50442881(SILYBIN A)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of thrombin (unknown origin) assessed as hydrolysis of N-benzoyl-phenylalanylvalyl-arginine-paranitroanilideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM23416((+)-Catechin | CHEMBL311498 | (2R,3S)-2-(3,4-dihyd...)
Affinity DataKd:  4.92E+4nMAssay Description:Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50005093(CHEBI:3978 | CYANIN)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM23416((+)-Catechin | CHEMBL311498 | (2R,3S)-2-(3,4-dihyd...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM23417(cid_72276 | (-)-Epicatechin | (2R,3R)-2-(3,4-dihyd...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human thrombin amidolytic activity using D-Phe-Pip-Arg-pNA as substrate preincubated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM23417(cid_72276 | (-)-Epicatechin | (2R,3R)-2-(3,4-dihyd...)
Affinity DataKd:  5.19E+6nMAssay Description:Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetProthrombin(Human)
University of Lodz

Curated by ChEMBL
LigandPNGBDBM50005093(CHEBI:3978 | CYANIN)
Affinity DataKd:  8.63E+6nMAssay Description:Inhibition of human thrombin assessed as equilibrium dissociation constant at 50 to 1000 uM by BIAcore analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed