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Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 50043441
LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441228(CHEMBL2431029)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50131516(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441214(CHEMBL2431026)
Affinity DataIC50:  43nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  45nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  58nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441223(CHEMBL2431016)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441221(CHEMBL2431018)
Affinity DataIC50:  76nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441219(CHEMBL2431020)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441224(CHEMBL2431015)
Affinity DataIC50:  104nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441215(CHEMBL2431021)
Affinity DataIC50:  105nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441227(CHEMBL2431030)
Affinity DataIC50:  145nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 1 hr measured every 15 secs for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441218(CHEMBL2431022)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441226(CHEMBL2431031)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  274nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441222(CHEMBL2431017)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 1 hr measured every 15 secs for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50429818(CHEMBL2337691)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441217(CHEMBL2431024)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  349nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  350nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  419nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441216(CHEMBL2431025)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441227(CHEMBL2431030)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50429818(CHEMBL2337691)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441228(CHEMBL2431029)
Affinity DataIC50:  630nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441225(CHEMBL2431032)
Affinity DataIC50:  640nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441220(CHEMBL2431019)
Affinity DataIC50:  650nMAssay Description:Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  651nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441214(CHEMBL2431026)
Affinity DataIC50:  825nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441215(CHEMBL2431021)
Affinity DataIC50:  840nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  845nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441219(CHEMBL2431020)
Affinity DataIC50:  890nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441223(CHEMBL2431016)
Affinity DataIC50:  940nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  966nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441214(CHEMBL2431026)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50314222((R)-benzyl 3-(4-(but-2-ynyloxy)phenylsulfonamido)-...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441224(CHEMBL2431015)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441221(CHEMBL2431018)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441214(CHEMBL2431026)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50131516(2-(4-(but-2-ynyloxy)phenylsulfonamido)-N-hydroxyac...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441222(CHEMBL2431017)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441212(CHEMBL2431028)
Affinity DataIC50:  4.27E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441215(CHEMBL2431021)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50441213(CHEMBL2431027)
Affinity DataIC50:  5.64E+3nMAssay Description:Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-14(Human)
UniversitÀ

Curated by ChEMBL
LigandPNGBDBM50441226(CHEMBL2431031)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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