Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50044368
LigandChemical structure of BindingDB Monomer ID 31592BDBM31592(PF-2545920 | substituted pyrazole, 9 | US9138494, ...)
Affinity DataIC50: 0.646nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014884BDBM50014884(CHEMBL3262038)
Affinity DataIC50: 47nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014825BDBM50014825(CHEMBL3262031)
Affinity DataIC50: 54nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014905BDBM50014905(CHEMBL3262043)
Affinity DataIC50: 60nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014881BDBM50014881(CHEMBL3259842)
Affinity DataIC50: 65nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014906BDBM50014906(CHEMBL3262044)
Affinity DataIC50: 66nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014842BDBM50014842(CHEMBL3262032)
Affinity DataIC50: 85nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014903BDBM50014903(CHEMBL3262041)
Affinity DataIC50: 102nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014882BDBM50014882(CHEMBL3262036)
Affinity DataIC50: 112nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014897BDBM50014897(CHEMBL3262039)
Affinity DataIC50: 112nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014901BDBM50014901(CHEMBL3262040)
Affinity DataIC50: 138nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014739BDBM50014739(CHEMBL3262028)
Affinity DataIC50: 141nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014883BDBM50014883(CHEMBL3262037)
Affinity DataIC50: 145nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014824BDBM50014824(CHEMBL3262030)
Affinity DataIC50: 155nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014718BDBM50014718(CHEMBL3262027)
Affinity DataIC50: 158nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014880BDBM50014880(CHEMBL3262035)
Affinity DataIC50: 234nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014904BDBM50014904(CHEMBL3262042)
Affinity DataIC50: 234nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014879BDBM50014879(CHEMBL3262034)
Affinity DataIC50: 257nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014878BDBM50014878(CHEMBL3262033)
Affinity DataIC50: 309nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014910BDBM50014910(CHEMBL3262046)
Affinity DataIC50: 347nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014909BDBM50014909(CHEMBL3262045)
Affinity DataIC50: 501nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014911BDBM50014911(CHEMBL3262047)
Affinity DataIC50: 562nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014817BDBM50014817(CHEMBL3262029)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014718BDBM50014718(CHEMBL3262027)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014718BDBM50014718(CHEMBL3262027)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE6A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014718BDBM50014718(CHEMBL3262027)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014718BDBM50014718(CHEMBL3262027)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014817BDBM50014817(CHEMBL3262029)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE6A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50014817BDBM50014817(CHEMBL3262029)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014739BDBM50014739(CHEMBL3262028)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014739BDBM50014739(CHEMBL3262028)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014739BDBM50014739(CHEMBL3262028)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014739BDBM50014739(CHEMBL3262028)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014817BDBM50014817(CHEMBL3262029)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014739BDBM50014739(CHEMBL3262028)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014817BDBM50014817(CHEMBL3262029)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed