Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 50044438
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017018(CHEMBL3183090)
Affinity DataKi:  4.30nMAssay Description:Competitive inhibition of C-terminal His6-tagged human recombinant SphK1 expressed in baculovirus-infected Sf9 cells using sphingosine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50443385(SPC-100270 | Safingol | Safingol HCl)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017017(CHEMBL3287037)
Affinity DataKi:  3.10E+3nMAssay Description:Competitive inhibition of human recombinant SphK1 using sphingosine and ATP as substrate by ADP-Quest kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017017(CHEMBL3287037)
Affinity DataKi:  4.20E+3nMAssay Description:Competitive inhibition of human recombinant SphK2 using sphingosine and ATP as substrate by ADP-Quest kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of SphK2 (unknown origin) using sphingosine and [gamma-32P]ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50240721((E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  9.80E+3nMAssay Description:Competitive inhibition of human recombinant SphK2 assessed as NBD-S1P formation using NBD-Sph as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50240721((E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50393641(CHEMBL2158686)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017015(CHEMBL3287035)
Affinity DataIC50:  40nMAssay Description:Inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50017015(CHEMBL3287035)
Affinity DataIC50:  300nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
Penn State Hershey Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50443389(CHEMBL2376441)
Affinity DataIC50:  1.00E+4nMAssay Description:Competitive inhibition of V5-His-tagged human SphK2 expressed in HEK293 cells assessed as S1P production using sphingosine and [gamma-32P]ATP as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed