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Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50043945
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of ROS1 (unknown origin) by Pfizer mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human wild type EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  2nMAssay Description:Inhibition of FER (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLeukocyte tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  2nMAssay Description:Inhibition of LTK (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBDNF/NT-3 growth factors receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  4nMAssay Description:Inhibition of NTRK2 (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Fes/Fps(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  5nMAssay Description:Inhibition of FES (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  12nMAssay Description:Inhibition of PTK2B (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  12nMAssay Description:Inhibition of JAK2 (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivated CDC42 kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  15nMAssay Description:Inhibition of TNK2 (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  16nMAssay Description:Inhibition of PTK2 (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  17nMAssay Description:Inhibition of NTRK1 (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNT-3 growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50:  18nMAssay Description:Inhibition of NTRK3 (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human wild type EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)