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Found 8 Enz. Inhib. hit(s) with all data for entry = 50040344
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant renin compound treated for 10 mins before substrate addition measured after 90 mins by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant renin compound treated for 10 mins before substrate addition measured after 90 mins by fluorescence methodMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
TargetRenin(Macaca fascicularis)
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of cynomolgus monkey plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Macaca fascicularis)
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  8nMAssay Description:Inhibition of cynomolgus monkey plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50392953(CHEMBL2152353)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed