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Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50044167
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  4nMAssay Description:Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  11nMAssay Description:Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human TNKS-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Mouse)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-1(Mouse)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human TNKS-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPoly [ADP-ribose] polymerase 1(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPoly [ADP-ribose] polymerase 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PARP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed