Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50043888
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 51nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 482158BDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448037BDBM50448037(CHEMBL3115500)
Affinity DataIC50: 340nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataEC50:  575nMAssay Description:Competitive inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448048BDBM50448048(CHEMBL3115504)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448048BDBM50448048(CHEMBL3115504)
Affinity DataIC50: 840nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448035BDBM50448035(CHEMBL3115499)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataEC50:  2.04E+3nMAssay Description:Competitive inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448047BDBM50448047(CHEMBL3115503)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448040BDBM50448040(CHEMBL3115496)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448046BDBM50448046(CHEMBL3115493)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448044BDBM50448044(CHEMBL3115497)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448045BDBM50448045(CHEMBL3115502)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448044BDBM50448044(CHEMBL3115497)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448043BDBM50448043(CHEMBL3115501)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataEC50:  2.28E+4nMAssay Description:Competitive inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448035BDBM50448035(CHEMBL3115499)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448036BDBM50448036(CHEMBL3115495)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448042BDBM50448042(CHEMBL3115494)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448041BDBM50448041(CHEMBL3115492)
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448040BDBM50448040(CHEMBL3115496)
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448039BDBM50448039(CHEMBL3115491)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448038BDBM50448038(CHEMBL3115498)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
University of Lyon

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448037BDBM50448037(CHEMBL3115500)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed